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2. Implementation of Guidelines for the Treatment of Acute ST-Elevation Myocardial Infarction

Author

Flesch, Markus, primary, Hagemeister, Jens, additional, Berger, Hans-Joerg, additional, Schiefer, Annett, additional, Schynkowski, Sylke, additional, Klein, Martin, additional, Sahebdjami, Sassan, additional, vom Dahl, Stephan, additional, Fehske, Wolfgang, additional, Mies, Rudolf, additional, von Eiff, Michael, additional, Pfaff, Holger, additional, Frommolt, Peter, additional, and Hoepp, Hans-Wilhelm, additional

Published
2008
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3. Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) and Urokinase in Acute Myocardial Infarction: Results of the German Activator Urokinase Study (GAUS)

Author

Neuhaus, Karl-Ludwig, Tebbe, Ulrich, Gottwik, Martin, Weber, Michael A.J., Feuerer, Werner, Niederer, Walter, Haerer, Winfried, Praetorius, Frank, Grosser, Klaus-Dieter, Huhmann, Wolfgang, Hoepp, Hans-Wilhelm, Alber, Guenter, Sheikhzadeh, Abdohlhamid, and Schneider, Berthold

Abstract

The effects of recombinant tissue plasminogen activator (rt-PA) and urokinase on patency and early reocclusion of infarct-related coronary arteries were investigated in a single blind, randomized multicenter trial in 246 patients with acute myocardial infarction of < 6 h duration. Both 70 mg of single chain rt-PA with an initial bolus of 10 mg and 3 million units of urokinase with an initial bolus of 1.5 million units were given intravenously over 90 min. The first angiographic study at the end of the infusion revealed a patent infarct-related artery (Thrombolysis in Myocardial Infarction trial [TIMI] grade 2 or 3) in 69.4% of 121 patients given rt-PA versus 65.8% of 117 patients given urokinase (p = NS). Among patients treated within 3 h from symptom onset a patent infarct-related artery was found in 63.9% of 72 patients given rt-PA versus 70% of 70 patients given urokinase (p = NS).

Published
1988
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