27 results on '"Heimer, S."'
Search Results
2. Styposis clausis Levi, 1960 (Arachnida: Araneida: Theridiidae) from Sierra Nevada de Santa Marta (Colombia) and functional morphology of its copulatory organs
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Heimer, S, Muller, H-G, and BioStor
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- 1991
3. Increased occupational physical activity does not improve physical fitness
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Ruzic, L, Heimer, S, Misigoj-Durakovic, M, and Matkovic, B R
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- 2003
4. Structure of polydispersed colloids characterised by light scattering and electron microscopy
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Heimer, S and Težak, D
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- 2002
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5. Adipose derived stem cells protect skin flaps against ischemia-reperfusion injury
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Reichenberger, M, Heimer, S, Müller, W, Gebhard, M-M, Pelzer, M, Germann, G, and Köllensperger, E
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ddc: 610 ,cardiovascular diseases ,610 Medical sciences ,Medicine ,eye diseases - Abstract
Background: Advances in the treatment of ischemia- reperfusion injury have created an opportunity for plastic surgeons to apply these treatments to flaps and implanted tissues. Using an extended inferior epigastric artery skin flap as a flap ischemia-reperfusion injury (IRI) model, we examined the capability[for full text, please go to the a.m. URL], 43. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC)
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- 2012
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6. Local application of adipose derived stem cells enhance skin flap survival
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Reichenberger, Matthias, Heimer, S., Schaefer, A., Müller, W., Gebhard, M., Pelzer, M., Germann, G., Czermak, C., Leimer, U., and Köllensperger, E.
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ddc: 610 ,610 Medical sciences ,Medicine ,eye diseases - Abstract
Introduction: Skin flap necrosis caused by insufficient blood supply is a common complication reconstructive surgery. A number of methods have been described to augment viability of skin flaps. Adipose derived stem cells (ASCs) have the potential for differentiation into several types of cells, incl[for full text, please go to the a.m. URL], 49. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie (ÖGPÄRC), 42. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 16. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC)
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- 2011
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7. Physical fitness of active and inactive women aged 50-65
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Rakovac, M, Heimer, S, Tonkovic-Lojovic, M, Beri, S, Mechling, Heinz, Brach, Michael, Eichberg, Sabine, and Preuss, Peter
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ddc: 610 ,postmenopause ,physical activity ,physical fitness - Abstract
OBJECTIVE: It is well documented that regular aerobic physical activity increases exercise capacity and physical fitness, leading to many health benefits (Vanhees et al., 2005), especially for women of postmenopausal age (Asikainen et al., 2004). The aim of this study was to compare physical fitness of regularly active to inactive women aged 50-65 yrs and to compare the results with Eurofit norms for adult population of the Republic of Croatia. METHODS: The sample consisted of 216 women, aged 50-65 yrs. 116 women had been participating in regular physical activity (aerobic classes 2-4 times a week) for at least 5 years, whereas 100 women had never participated in any kind of regular physical activity. Physical fitness of the participants was evaluated with the Eurofit test battery (Oja et al., 1995). Women were subjected to tests measuring body composition (body weight and height, and waist and hip circumference), aerobic fitness (Astrand's cycle ergometer test), motor fitness (single leg balance test, plate tapping), and musculoskeletal fitness (sit-ups, sit-and-reach, vertical jump, hand grip). T-test was used in data analysis. RESULTS: Statistically significant differences between the two groups were found in the five observed variables in favour of the active group. Namely, single leg balance test – attempts/30s (active 5.4 ± ; 5.6 vs inactive 8.9 ± ; 8.9, t= -3.43, p=0.001), sit-ups - n/30s (10.6 ± ; 6.6 vs 5.1 ± ; 5.2, t=6.74, p=0.000), plate tapping - n/20s (39.1 ± ; 7.9 vs 35.9 ± ; 5.6, t=3.30, p=0.001), absolute maximal oxygen uptake (V02max) – LO2/min (1.5 ± ; 0.7 vs 1.2 ± ; 0.7, t=2.82, p=0.005) and relative V02max - ml O2/ kg/min (21.6 ± ; 10.9 vs 17.8 ± ; 10.7, t=2.61, p=0.009). CONCLUSIONS: Compared to the inactive group, the regularly active women showed significantly better results in five variables describing motor, musculoskeletal and aerobic fitness. Moreover, the results of the regularly active women were above the average even when compared with the respective gender and age group Eurofit norms for adult population of the Republic of Croatia (Heimer et al., 2004). These results point to the positive effects of regular recreational physical activity and its potential for the improvement of physical fitness, and, at the same time, health enhancement of female population of this age group. LITERATURE: Asikainen TM, Kukkonen-Harjula K, Miilunpalo S. Exercise for health for early postmenopausal women: A systematic review of randomised controlled trials. Sports Med 2004 ; 34(11):753-778. Heimer S, Misigoj-Durakovic M, Ruzic L, Matkovic B, Prskalo I, Beri S, Tonkovic-Lojovic M. Fitness level of adult economically active population in the Republic of Croatia estimated by EUROFIT system. Coll Antropol 2004 ; 28(1):223-33. Oja P, Tuxworth B. EUROFIT for adults, Council of Europe, 1995 ; 5– 104. Vanhees L, Lefevre J, Philippaerts R, et al. How to assess physical activity? How to assess physical fitness? Eur J Cardiovasc Prev Rehabil 2005 ; 12(2):102-14.
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- 2006
8. Adipose derived stem cells enhance skin flap survival
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Reichenberger, M, Heimer, S, Schaefer, A, Müller, W, Gebhard, M, Pelzer, M, Germann, G, Leimer, U, Köllensperger, E, Reichenberger, M, Heimer, S, Schaefer, A, Müller, W, Gebhard, M, Pelzer, M, Germann, G, Leimer, U, and Köllensperger, E
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- 2011
9. Local application of adipose derived stem cells enhance skin flap survival
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Reichenberger, M, Heimer, S, Schaefer, A, Müller, W, Gebhard, M, Pelzer, M, Germann, G, Czermak, C, Leimer, U, Köllensperger, E, Reichenberger, M, Heimer, S, Schaefer, A, Müller, W, Gebhard, M, Pelzer, M, Germann, G, Czermak, C, Leimer, U, and Köllensperger, E
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- 2011
10. Anelosimus
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Heimer, S., Nentwig, W.
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Arthropoda ,Anelosimus ,Arachnida ,Animalia ,Araneae ,Biodiversity ,Theridiidae ,Taxonomy - Abstract
Anelosimus (3 Arten) 1 ♂ Pdp. erscheint scheibenförmig (Abb. 757.1), Epg. hi. von breitem Chitin¬ wulst begrenzt (Abb. 757.3), Vulva Abb. 757.4, ProS. gelblich-orange mit schmalem, dunklem Rand u. breitem, braunem Mittelstreifen, Ster, rötlich ¬ gelb, Rand verdunkelt, Chel. gelblich, Beine gelblich, braun geringelt, OpS. hell gelblich, mitunter auch weiß od. rötlich, mit breitem, braunem Mittel¬ streifen (Abb. 757.5), KL 3.5-4.5 mm, auf Sträuchern in sehr warmen Gegen¬ den, ad. Frühsommer, mediterrane Art, stellenweise in MEu (= Theridion a.) aulicus (C. L. KOCH) - ♂ Pdp. länglich, Epg. mit nach vorne gerichtetem Scap. 2 2 ♂ Pdp. mit breitem, gebogenem (>) Fortsatz nahe der Basis des Blb. (Abb. 758.1), Scap. der Epg. löffelartig verbreitert (Abb. 758.3), Vulva Abb. 758.4, in Färb. u. Zeichnung der vorigen Art sehr ähnlich, KL 3-4 mm, häufige Art auf Bäumen u. Sträuchern, meist an sonnigen Waldrändern, ad. Frühsommer, weit verbreitet, im Gebirge selten, Eu (= Theridion v.) vittatus (C. L. KOCH) - ♂ Pdp. ohne solchen Fortsatz (Abb. 759.1), Scap. der Epg. in ganzer Länge gleichbreit (Abb. 759.3), Vulva Abb. 759.4, in Färb. u. Zeichnung den beiden anderen Atielosimus-Aiten sehr ähnlich, KL 3.5-4.5 mm, selten gefunden (mit vittatus verwechselt?), auf Bäumen u. Sträuchern, ad. Frühsommer, weit ver¬ breitet, SEu, MEu (= Theridion p.) pulchellus (WALCKENAER)
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- 1991
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11. Crustulina
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Heimer, S.
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Arthropoda ,Arachnida ,Animalia ,Araneae ,Biodiversity ,Theridiidae ,Crustulina ,Taxonomy - Abstract
Crustulina (2 Arten) 1 Fortsatz des Cym. (>) dist. quer abgestutzt, mit feinen H��ckern, Kond. (") spitz (Abb. 761.1), Epg. deutl. 2teilig (Abb. 761.3), Vulva Abb. 761.4, ProS. dunkelbraun, mitunter leuchtend rotbraun, Ster. u. Chel. dunkelbraun, Beine kurz u. kr��ftig, dunkelbraun, undeutl. geringelt, OpS. fast kreisrund, braun, dors, mit 3 L��ngsreihen wei��er Flecken (selten fehlend), KL 2.0-2.5 mm, h��ufige Art am Boden lichter Waldstellen, ad. ganzj��hrig, weit verbreitet, Eu guttata (WIDER) - Fortsatz des Cym. (>) sehr lang u. spitz auslaufend (Abb. 762.2), Kond. (") dist. gerundet (Abb. 762.1), Epg.begrenzung bogenf��rmig, einfach (Abb. 762.1), Vulva Abb. 762.4, ProS., Ster., Chel. u. Beine dunkelbraun, Beine nicht geringelt, OpS. dors. wei��lich mit r��tlichbraunen Punkten, lat. u. ventr. braun, selten OpS. ganz schwarz, KL um 2.5 mm, in Mooren u. S��mpfen, sel�� ten gefunden, WEu, MEu sticta (O. P. - CAMBRIDGE), Published as part of Heimer, S., Nentwig, W., 1991, Spinnen Mitteleuropas - Ein Bestimmungsbuch (Excerpt), Berlin und Hamburg :Verlag Paul Parey on page 282
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- 1991
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12. Anelosimus
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Heimer, S.
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Arthropoda ,Anelosimus ,Arachnida ,Animalia ,Araneae ,Biodiversity ,Theridiidae ,Taxonomy - Abstract
Anelosimus (3 Arten) 1 ♂ Pdp. erscheint scheibenf��rmig (Abb. 757.1), Epg. hi. von breitem Chitin�� wulst begrenzt (Abb. 757.3), Vulva Abb. 757.4, ProS. gelblich-orange mit schmalem, dunklem Rand u. breitem, braunem Mittelstreifen, Ster, r��tlich �� gelb, Rand verdunkelt, Chel. gelblich, Beine gelblich, braun geringelt, OpS. hell gelblich, mitunter auch wei�� od. r��tlich, mit breitem, braunem Mittel�� streifen (Abb. 757.5), KL 3.5-4.5 mm, auf Str��uchern in sehr warmen Gegen�� den, ad. Fr��hsommer, mediterrane Art, stellenweise in MEu (= Theridion a.) aulicus (C. L. KOCH) - ♂ Pdp. l��nglich, Epg. mit nach vorne gerichtetem Scap. 2 2 ♂ Pdp. mit breitem, gebogenem (>) Fortsatz nahe der Basis des Blb. (Abb. 758.1), Scap. der Epg. l��ffelartig verbreitert (Abb. 758.3), Vulva Abb. 758.4, in F��rb. u. Zeichnung der vorigen Art sehr ��hnlich, KL 3-4 mm, h��ufige Art auf B��umen u. Str��uchern, meist an sonnigen Waldr��ndern, ad. Fr��hsommer, weit verbreitet, im Gebirge selten, Eu (= Theridion v.) vittatus (C. L. KOCH) - ♂ Pdp. ohne solchen Fortsatz (Abb. 759.1), Scap. der Epg. in ganzer L��nge gleichbreit (Abb. 759.3), Vulva Abb. 759.4, in F��rb. u. Zeichnung den beiden anderen Atielosimus-Aiten sehr ��hnlich, KL 3.5-4.5 mm, selten gefunden (mit vittatus verwechselt?), auf B��umen u. Str��uchern, ad. Fr��hsommer, weit ver�� breitet, SEu, MEu (= Theridion p.) pulchellus (WALCKENAER), Published as part of Heimer, S., Nentwig, W., 1991, Spinnen Mitteleuropas - Ein Bestimmungsbuch (Excerpt), Berlin und Hamburg :Verlag Paul Parey on page 282
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- 1991
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13. Comaroma
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Heimer, S., Nentwig, W.
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Arthropoda ,Arachnida ,Animalia ,Araneae ,Anapidae ,Biodiversity ,Comaroma ,Taxonomy - Abstract
Comaroma (1 Art) KL ~ 1.6 mm, VMA sehr kl., mitunter vollständig red., ProS. rotbraun mit dunklerem Rand, Ster. u. Chel. rotbraun, Beine kurz u. kräftig, rotbraun, Pat. heller, OpS. breit u. flach, dors. u. ventr. mit rotbraunen Scuta u. zahlreichen, kl. Chitinplättchen, ♂ Pdp. mit gegenüber der Tib. angeknicktem Cym. u. kurzem, kräftigem Emb. (Abb. 760.1), Epg. nur an den durchscheinenden Rec.Sem. zu erkennen, Vulva wie Abb. 760.4, im Alpen- u. Karpatengebiet in der Laubstreu feuchter Wälder, ad. IV-V, SOEu u. Alpen simoni Bertkau
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- 1991
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14. Interactions of mercury(II), lead(II), calcium(II), aluminium(III) or ferric(III) nitrate with single and double chain linear alkylbenzenesulfonates in aqueous and sea-water media
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Težak, Đ., primary, Babačić, O., additional, Đerek, V., additional, Galešić, M., additional, Heimer, S., additional, Hrust, V., additional, Ivezić, Z., additional, Jurković, D., additional, Rupčić, S., additional, and Zelović, V., additional
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- 1994
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15. Fitness level of adult economically active population in the Republic of Croatia estimated by EUROFIT system
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Heimer, S., Mišigoj-Duraković, M., Lana Ruzic, Matković, B., Prskalo, I., Beri, S., and Tonković-Lojović, M.
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Adult ,Employment ,Male ,Croatia ,education ,Health Promotion ,Middle Aged ,Eurofit ,physical fitness ,aerobic capacity ,Health Surveys ,Age Distribution ,Physical Fitness ,Humans ,Female ,Sex Distribution - Abstract
The study presents the results of the EUROFIT CROATIA project that was conducted according to the instructions of Council of Europe. The aim of the study was evaluation of fitness level of the employed Croatian population. The measurements comprised EUROFIT battery of tests as well as Baecke's questionnaire for evaluation of habitual physical activity. The sample was comprised of 1628 active inhabitants, 18-60 years of age, all of who were employed and living in Croatia. The obtained results of functional, motor and morphological characteristics were presented according to the sex and age. The results showed poor aerobic capacity, high obesity indicators and low motor performance in both sexes, which pointed to the increased risk for developing many cardiovascular or musculo- skeletal diseases. The overall fitness level of Croatian population showed to be unsatisfactory and it should be improved by engagement in sports-recreational activities.
16. On safety analysis for underground constructions during design and optimisation.
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Skrzyppek J., Heimer S., Pieper C., Skrzyppek J., Heimer S., and Pieper C.
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Many underground structures, such as underground waste repositories, are required for particular functions and loads which demand high standards of construction; most are expected to fulfil these functions for long periods and have to be constructed under difficult conditions. As the concept of risk is increasingly stressed in regulations and laws concerning the safe construction of such structures, modern methods of safety analysis and of quantitative engineering are being used for their design and optimisation. The concepts and methods are described and the schematic example given of shaft sealing for an air-filled potash mine. The protective requirements for the sealing are enumerated, possible risk scenarios considered, system components outlined, the closure plan set out and safety calculations explained., Many underground structures, such as underground waste repositories, are required for particular functions and loads which demand high standards of construction; most are expected to fulfil these functions for long periods and have to be constructed under difficult conditions. As the concept of risk is increasingly stressed in regulations and laws concerning the safe construction of such structures, modern methods of safety analysis and of quantitative engineering are being used for their design and optimisation. The concepts and methods are described and the schematic example given of shaft sealing for an air-filled potash mine. The protective requirements for the sealing are enumerated, possible risk scenarios considered, system components outlined, the closure plan set out and safety calculations explained.
17. Crack closure and crack path prediction for curved cracks under thermal load
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Gross, D. and Heimer, S.
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- 1993
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18. Preventivni I Terapeutski Programi Vježbanja Kod Šećerne Bolesti
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Sporiš, Goran, Milanović, Zoran, Pantelić, Saša, Trajković, Nebojša, and Heimer, S.
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šećerna bolest ,tjelesna aktivnost - Abstract
Dijabetes je kao bolest dobila epidemiološke razmjere, kako u razvijenim tako i u zemljama u razvoju (Colberg et al., 2010). Dijabetes je kronična bolest od koje u Hrvatskoj boluje više od 170.000 osoba te predstavlja četvrti uzrok smrti. Dijabetes je bolest koja ne boli dok se ne pojave komplikacije i zato je mnogi ne shvaćaju ozbiljno (Colberg et al., 2010). Zbog toga postoji potreba za poticanjem svijesti opće populacije, ali i državnih institucija o važnosti prevencije i liječenja ove bolesti. Temelji toga su edukacija o bolesti, pravilna prehrana, postizanje optimalne tjelesne težine, pojačana tjelesna aktivnost, svakodnevna kontrola te lijekovi (Association, 2002). Utvrđeno je da se tjelesnom aktivnošću liječe razne bolesti, a osobitu ulogu tjelesna aktivnost ima kad je riječ o dijabetesu (Balducci et al., 2006). Tjelesna aktivnost na mnoge načine koristi snižavanju razine šećera u krvi, povećanju djelotvornosti liječenja i mogućnosti gubitka na težini. Vježbanje također snižava krvni tlak, što je dobro za srce te jača mišiće i zglobove (Fagard & Cornelissen, 2007). Konačno, povećanje razine fitnesa doprinijet će i povećanju samopouzdanja, što bolesnicima oboljelima od šećerne bolesti pomaže da se osjećaju bolje. Bolesnicima nerijetko nedostaje prijeko potrebna motivacija za svakodnevnu tjelesnu aktivnost, a ta spoznaja rezultirala je stvaranjem raznih programa, koji bi približili tjelesnu aktivnost dijabetičarima. U planiranju i realizaciji takvih programa izuzetno je važna suradnja dijabetologa, kineziologa, ali i samih bolesnika dijabetičara koji bi svojevoljno odabrali tjelesnu aktivnost kojom se žele baviti. Sudjelovanje dijabetološkog i kineziološkog tima također daje će sigurnost dijabetičaru u provođenju programa.
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- 2013
19. Blood Pressure Loci Identified with a Gene-Centric Array
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Meena Kumari, Claire E. Hastie, Jonathan Stephens, Patricia B. Munroe, Christopher P. Nelson, John M. C. Connell, Martin D. Tobin, Hani Neuvrith, Jean Tichet, Paul Burton, Gudrun Veldre, Daniele Cusi, Anna Levinsson, Paul Elliott, Elin Org, Erika Salvi, Tina Shah, Nabila Devos, Harm-Jan Westra, Juan-Pablo Casas, Olle Melander, Jan A. Staessen, Nilesh J. Samani, Jackie A. Cooper, Peter S. Braund, Neil R Poulter, Alive V. Stanton, Abiodun Onipinla, Marcel G. M. Wolfs, Steve E. Humphries, Philippa J. Talmud, Rebecca Hardy, Fotios Drenos, Maris Laan, Mark J. Caulfield, Richard Dobson, Willem H. Ouwehand, Yun Zhang, Li Chen, SG Wannamethee, Sue Shaw-Hawkins, Christopher Newton-Cheh, Eoin O'Brien, Simon A. McG. Thom, Maria Grazia Franzosi, Charles A. Mein, Mika Kivimäki, Tom R. Gaunt, Jennifer G. Sambrook, Andrea Stucchi, Annika Rosengren, Sonia Shah, Thomas Hedner, George A. Wells, Dag S. Thelle, Debbie A Lawlor, Pierre-François Plouin, Fredrik Nyberg, Richard W Morris, Ian N M Day, Vesela Gateva, Lude Franke, Peter S. Sever, Morris J. Brown, Margus Putku, Sandosh Padmanabhan, John F. Peden, Pim van der Harst, Jutta Palmen, Ioanna Tzoulaki, Alexandre F.R. Stewart, Andrew Wong, Peeter Juhanson, Marciej Tomaszewski, Alison H. Goodall, Martin Farrall, Wai K. Lee, Nicola Glorioso, Hugh Watkins, Xavier Jeunemaitre, Anders Hamsten, Robert Clarke, Anna F. Dominiczak, Mark Lathrop, Stephen Newhouse, Margus Viigimaa, George Davey Smith, Robert Roberts, John C. Whittaker, Michael V. Holmes, Toby Johnson, F. Gerald R. Fowkes, Aroon D. Hingorani, Udo Seedorf, Siim Sõber, Denis C. Shields, Diana Kuh, Chris Wallace, Philip Howard, Peter H. Whincup, Gonçalo R. Abecasis, Anuj Goel, Christian Delles, Björn Wahlstrand, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Cardiovascular Centre (CVC), Stem Cell Aging Leukemia and Lymphoma (SALL), Cardiogenics Consortium, Global BPgen Consortium, Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M.D., Bochud, M., Coin, L., Najjar, S.S., Hua, J., Heath, S.C., Eyheramendy, S., Papadakis, K., Voight, B.F., Scott, L.J., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, J.C., Khaw, K.T., Nilsson, P., van der Harst, P., Polidoro, S., Grobbee, D.E., Onland-Moret, N.C., Bots, M.L., Wain, L.V., Elliott, K.S., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, P.R., Hadley, D., McArdle, W.L., Wellcome Trust Case Control Consortium, X, Brown, M., Dominiczak, A., Newhouse, S.J., Samani, N.J., Webster, J., Zeggini, E., Beckmann, J.S., Bergmann, S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, D.M., Yuan, X., Groop, L., Orho, M., Allione, A., Di Gregorio, A., Guarrera, S., Panico, S., Ricceri, F., Romanazzi, V., Sacerdote, C., Vineis, P., Barroso, I., Sandhu, M.S., Luben, R.N., Crawford, G.J., Jousilahti, P., Perola, M., Boehnke, M., Bonnycastle, L.L., Collins, F.S., Jackson, A.U., Mohlke, K.L., Stringham, H.M., Valle, T.T., Willer, C.J., Bergman, R.N., Morken, M.A., Döring, A., Gieger, C., Illig, T., Meitinger, T., Org, E., Pfeufer, A., Wichmann, H.E., Kathiresan, S., Marrugat, J., O'Donnell, C.J., Schwartz, S.M., Siscovick, D.S., Subirana, I., Freimer, N.B., Hartikainen, A.L., McCarthy, M.I., OReilly, P.F., Peltonen, L., Pouta, A., de Jong, P.E., Snieder, H., van Gilst, W.H., Clarke, R., Goel, A., Hamsten, A., Peden, J.F., Seedorf, U., Syv, C., Tognoni, G., Lakatta, E.G., Sanna, S., Scheet, P., Schlessinger, D., Scuteri, A., Dörr, M., Ernst, F., Felix, S.B., Homuth, G., Lorbeer, R., Reffelmann, T., Rettig, R., Völker, U., Galan, P., Gut, I.G., Hercberg, S., Lathrop, G.M., Zeleneka, D., Deloukas, P., Soranzo, N., Williams, F.M., Zhai, G., Salomaa, V., Laakso, M., Elosua, R., Forouhi, N.G., Völzke, H., Uiterwaal, C.S., van der Schouw, Y.T., Numans, M.E., Matullo, G., Navis, G., Berglund, G., Bingham, S.A., Kooner, J.S., Paterson, A.D., Connell, J.M., Bandinelli, S., Ferrucci, L., Watkins, H., Spector, T.D., Tuomilehto, J., Altshuler, D., Strachan, D.P., Laan, M., Meneton, P., Wareham, N.J., Uda, M., Jarvelin, M.R., Mooser, V., Melander, O., Loos, R.J., Elliott, P., Abecasis, G.R., Caulfield, M., Munroe, P.B., Attwood, T., Belz, S., Braund, P., Brocheton, J., Cambien, F., Cooper, J., Crisp-Hihn, A., Diemert, P., Eardman, J., Foad, N., Godefroy, T., Goodall, A.H., Gracey, J., Gray, E., Gwilliams, R., Heimer, S., Hengstenberg, C., Jolley, J., Krishnan, U., Lloyd-Jones, H., Liljedahl, U., Lugauer, I., Lundmark, P., Maouche, S., Moore, J.S., Montalescot, G., Muir, D., Murray, E., Nelson, C.P., Neudert, J., Niblett, D., O'Leary, K., Ouwehand, W.H., Pollard, H., Proust, C., Rankin, A., Rendon, A., Rice, C.M., Sager, H.B., Sambrook, J., Schmitz, G., Scholz, M., Schroeder, L., Schunkert, H., Stephens, J., Syvannen, A.C., and Tennstedt, S.
- Subjects
Male ,Linkage disequilibrium ,Methylenetetrahydrofolate Reductase (NADPH2)/genetics ,cardiovascular-disease ,population ,Genome-wide association study ,Genetic Loci ,Blood Pressure ,ANGIOTENSINOGEN ,030204 cardiovascular system & hematology ,Linkage Disequilibrium ,0302 clinical medicine ,Gene Frequency ,Receptors ,common variants ,Genetics(clinical) ,ESSENTIAL-HYPERTENSION ,Genetics (clinical) ,POPULATION ,Oligonucleotide Array Sequence Analysis ,Genetics ,0303 health sciences ,education.field_of_study ,Adult ,Aged ,Blood Pressure/genetics ,Case-Control Studies ,Female ,Gene Expression Profiling ,Genome-Wide Association Study ,Haplotypes ,Humans ,Hypertension/genetics ,Middle Aged ,Plasma Membrane Calcium-Transporting ATPases/genetics ,Polymorphism, Single Nucleotide ,Receptors, Atrial Natriuretic Factor/genetics ,Sequence Analysis, DNA ,COMMON VARIANTS ,Single Nucleotide ,3. Good health ,SNP genotyping ,CARDIOVASCULAR-DISEASE ,Hypertension ,Sequence Analysis ,Atrial Natriuretic Factor ,QUANTITATIVE-TRAIT LOCI ,metaanalysis ,essential-hypertension ,SUSCEPTIBILITY LOCI ,Population ,Single-nucleotide polymorphism ,Biology ,Article ,03 medical and health sciences ,Plasma Membrane Calcium-Transporting ATPases ,Polymorphism ,GENOME-WIDE ASSOCIATION ,education ,Genotyping ,Allele frequency ,METAANALYSIS ,Methylenetetrahydrofolate Reductase (NADPH2) ,030304 developmental biology ,quantitative-trait loci ,Haplotype ,Receptors, Atrial Natriuretic Factor ,DNA ,susceptibility loci ,angiotensinogen ,Hypertension/*genetics ,genome-wide association ,linkage disequilibrium - Abstract
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 x 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery, and follow-up data identified SNPs significantly associated with BP at p < 8.56 x 10(-7) at four further loci (NPR3, FIFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies. ispartof: American Journal of Human Genetics vol:89 issue:6 pages:688-700 ispartof: location:United States status: published
- Published
- 2011
20. Subcellular localization of PD-L1 and cell-cycle-dependent expression of nuclear PD-L1 variants: implications for head and neck cancer cell functions and therapeutic efficacy.
- Author
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Schulz D, Feulner L, Santos Rubenich D, Heimer S, Rohrmüller S, Reinders Y, Falchetti M, Wetzel M, Braganhol E, Lummertz da Rocha E, Schäfer N, Stöckl S, Brockhoff G, Wege AK, Fritsch J, Pohl F, Reichert TE, Ettl T, and Bauer RJ
- Subjects
- Humans, Cell Cycle, Squamous Cell Carcinoma of Head and Neck genetics, Vimentin, B7-H1 Antigen metabolism, Head and Neck Neoplasms genetics
- Abstract
The programmed cell death 1 ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) axis is primarily associated with immunosuppression in cytotoxic T lymphocytes (CTLs). However, mounting evidence is supporting the thesis that PD-L1 not only functions as a ligand but mediates additional cellular functions in tumor cells. Moreover, it has been demonstrated that PD-L1 is not exclusively localized at the cellular membrane. Subcellular fractionation revealed the presence of PD-L1 in various cellular compartments of six well-characterized head and neck cancer (HNC) cell lines, including the nucleus. Via Western blotting, we detected PD-L1 in its well-known glycosylated/deglycosylated state at 40-55 kDa. In addition, we detected previously unknown PD-L1 variants with a molecular weight at approximately 70 and > 150 kDa exclusively in nuclear protein fractions. These in vitro findings were confirmed with primary tumor samples from head and neck squamous cell carcinoma (HNSCC) patients. Furthermore, we demonstrated that nuclear PD-L1 variant expression is cell-cycle-dependent. Immunofluorescence staining of PD-L1 in different cell cycle phases of synchronized HNC cells supported these observations. Mechanisms of nuclear PD-L1 trafficking remain less understood; however, proximity ligation assays showed a cell-cycle-dependent interaction of the cytoskeletal protein vimentin with PD-L1, whereas vimentin could serve as a potential shuttle for nuclear PD-L1 transportation. Mass spectrometry after PD-L1 co-immunoprecipitation, followed by gene ontology analysis, indicated interaction of nuclear PD-L1 with proteins involved in DNA remodeling and messenger RNA (mRNA) splicing. Our results in HNC cells suggest a highly complex regulation of PD-L1 and multiple tumor cell-intrinsic functions, independent of immune regulation. These observations bear significant implications for the therapeutic efficacy of immune checkpoint inhibition., (© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
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- 2024
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21. Hypertonicity counteracts MCL-1 and renders BCL-XL a synthetic lethal target in head and neck cancer.
- Author
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Heimer S, Knoll G, Neubert P, Hammer KP, Wagner S, Bauer RJ, Jantsch J, and Ehrenschwender M
- Subjects
- Antineoplastic Agents pharmacology, Apoptosis drug effects, Apoptosis genetics, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell pathology, Cell Line, Tumor, Drug Synergism, Head and Neck Neoplasms genetics, Head and Neck Neoplasms pathology, Humans, Mitochondria drug effects, Mitochondria metabolism, Myeloid Cell Leukemia Sequence 1 Protein antagonists & inhibitors, Myeloid Cell Leukemia Sequence 1 Protein genetics, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-bcl-2 metabolism, Pyrimidines pharmacology, RNA Interference, Thiophenes pharmacology, Tumor Microenvironment drug effects, bcl-X Protein antagonists & inhibitors, bcl-X Protein genetics, Carcinoma, Squamous Cell metabolism, Head and Neck Neoplasms metabolism, Myeloid Cell Leukemia Sequence 1 Protein metabolism, Osmotic Pressure physiology, bcl-X Protein metabolism
- Abstract
Head and neck squamous cell carcinoma (HNSCC) is an aggressive and difficult-to-treat cancer entity. Current therapies ultimately aim to activate the mitochondria-controlled (intrinsic) apoptosis pathway, but complex alterations in intracellular signaling cascades and the extracellular microenvironment hamper treatment response. On the one hand, proteins of the BCL-2 family set the threshold for cell death induction and prevent accidental cellular suicide. On the other hand, controlling a cell's readiness to die also determines whether malignant cells are sensitive or resistant to anticancer treatments. Here, we show that HNSCC cells upregulate the proapoptotic BH3-only protein NOXA in response to hyperosmotic stress. Induction of NOXA is sufficient to counteract the antiapoptotic properties of MCL-1 and switches HNSCC cells from dual BCL-XL/MCL-1 protection to exclusive BCL-XL addiction. Hypertonicity-induced functional loss of MCL-1 renders BCL-XL a synthetically lethal target in HNSCC, and inhibition of BCL-XL efficiently kills HNSCC cells that poorly respond to conventional therapies. We identify hypertonicity-induced upregulation of NOXA as link between osmotic pressure in the tumor environment and mitochondrial priming, which could perspectively be exploited to boost efficacy of anticancer drugs., (© 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
- Published
- 2021
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22. Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis.
- Author
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Heimer S, Knoll G, Schulze-Osthoff K, and Ehrenschwender M
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- Cyclopentanes therapeutic use, Cytochromes c metabolism, Fluorenes therapeutic use, HCT116 Cells, Humans, Mitochondria drug effects, Mitochondria metabolism, Neoplasms drug therapy, Neoplasms pathology, Proto-Oncogene Proteins c-bcl-2 antagonists & inhibitors, Signal Transduction drug effects, bcl-2 Homologous Antagonist-Killer Protein genetics, bcl-2-Associated X Protein genetics, Apoptosis drug effects, Cyclopentanes pharmacology, Fluorenes pharmacology, Mitochondrial Membranes metabolism, Neoplasms metabolism, Proto-Oncogene Proteins c-bcl-2 metabolism, bcl-2 Homologous Antagonist-Killer Protein metabolism, bcl-2-Associated X Protein metabolism
- Abstract
Most antineoplastic chemotherapies eliminate cancer cells through activation of the mitochondria-controlled intrinsic apoptotic pathway. Therein, BAX, BAK, and/or BOK function as the essential pore-forming executioners of mitochondrial outer membrane permeabilization (MOMP). The activation threshold of BAX and BAK also correlates inversely with the required strength of an apoptotic stimulus to induce MOMP and thereby effectively determines a cell's readiness to undergo apoptosis. Consequently, the 'gatekeepers' BAX and BAK emerged as therapeutic targets, but functional or genetic loss renders BAX/BAK-targeting strategies prone to fail. Here, we show that the small molecule Raptinal overcomes this limitation by triggering cytochrome c release in a BAX/BAK/BOK-independent manner. Raptinal exerts a dual cytotoxic effect on cancer cells by rapid activation of the intrinsic apoptotic pathway and simultaneous shutdown of mitochondrial function. Together with its efficacy to eliminate cancer cells in vivo, Raptinal could be useful in difficult-to-treat cancer entities harboring defects in the intrinsic apoptosis pathway.
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- 2019
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23. Spontaneous bacterial keratitis in CD36 knockout mice.
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Klocke J, Barcia RN, Heimer S, Cario E, Zieske J, Gilmore MS, Ksander BR, and Gregory MS
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- Animals, Corneal Ulcer pathology, Epithelium, Corneal metabolism, Eye Infections, Bacterial pathology, Female, Green Fluorescent Proteins metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Mucins metabolism, Polymerase Chain Reaction, RNA, Bacterial genetics, RNA, Ribosomal, 16S genetics, Staphylococcal Infections pathology, Staphylococcus aureus metabolism, Staphylococcus aureus pathogenicity, Thrombospondin 1 physiology, Tight Junctions metabolism, Toll-Like Receptor 2 physiology, CD36 Antigens physiology, Corneal Ulcer microbiology, Eye Infections, Bacterial microbiology, Staphylococcal Infections microbiology
- Abstract
Purpose: CD36 is a Class B scavenger receptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeostatic functions, including the homeostasis of the epidermal barrier. The aim of this study is to determine (1) whether CD36 is required for the maintenance of the corneal epithelial barrier to infection, and (2) whether CD36-deficient mice present with an increased susceptibility to bacterial keratitis., Methods: The corneas of CD36(-/-), TSP1(-/-), TLR2(-/-), and C57BL/6 WT mice were screened via slit lamp microscopy or ex vivo analysis. The epithelial tight junctions and mucin layer were assessed via LC-biotin and Rose Bengal staining, respectively. Bacterial quantification was performed on corneal buttons and GFP-expressing Staphylococcus aureus was used to study bacterial binding., Results: CD36(-/-) mice develop spontaneous corneal defects that increased in frequency and severity with age. The mild corneal defects were characterized by a disruption in epithelial tight junctions and the mucin layer, an infiltrate of macrophages, and increased bacterial binding. Bacterial quantification revealed high levels of Staphylococcus xylosus in the corneas of CD36(-/-) mice with severe defects, but not in wild-type controls., Conclusions: CD36(-/-) mice develop spontaneous bacterial keratitis independent of TLR2 and TSP1. The authors conclude that CD36 is a critical component of the corneal epithelial barrier, and in the absence of CD36 the barrier breaks down, allowing bacteria to bind to the corneal epithelium and resulting in spontaneous keratitis. This is the first report of spontaneous bacterial keratitis in mice.
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- 2011
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24. Interaction of Proteus mirabilis urease apoenzyme and accessory proteins identified with yeast two-hybrid technology.
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Heimer SR and Mobley HL
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- Antibodies, Bacterial, Apoenzymes genetics, Apoenzymes immunology, Bacterial Proteins genetics, Carrier Proteins genetics, Cloning, Molecular, DNA Primers, Gene Expression Regulation, Bacterial, Models, Chemical, Phosphate-Binding Proteins, Polymerase Chain Reaction, Precipitin Tests, Protein Binding, Recombinant Fusion Proteins metabolism, Repressor Proteins metabolism, Sequence Analysis, DNA, Serine Endopeptidases metabolism, Two-Hybrid System Techniques, Urease genetics, Urease immunology, Apoenzymes metabolism, Bacterial Proteins metabolism, Proteus mirabilis enzymology, Urease metabolism
- Abstract
Proteus mirabilis, a gram-negative bacterium associated with complicated urinary tract infections, produces a metalloenzyme urease which hydrolyzes urea to ammonia and carbon dioxide. The apourease is comprised of three structural subunits, UreA, UreB, and UreC, assembled as a homotrimer of individual UreABC heterotrimers (UreABC)(3). To become catalytically active, apourease acquires divalent nickel ions through a poorly understood process involving four accessory proteins, UreD, UreE, UreF, and UreG. While homologues of UreD, UreF, and UreG have been copurified with apourease, it remains unclear specifically how these polypeptides associate with the apourease or each other. To identify interactions among P. mirabilis accessory proteins, in vitro immunoprecipitation and in vivo yeast two-hybrid assays were employed. A complex containing accessory protein UreD and structural protein UreC was isolated by immunoprecipitation and characterized with immunoblots. This association occurs independently of coaccessory proteins UreE, UreF, and UreG and structural protein UreA. In a yeast two-hybrid screen, UreD was found to directly interact in vivo with coaccessory protein UreF. Unique homomultimeric interactions of UreD and UreF were also detected in vivo. To substantiate the study of urease proteins with a yeast two-hybrid assay, previously described UreE dimers and homomultimeric UreA interactions among apourease trimers were confirmed in vivo. Similarly, a known structural interaction involving UreA and UreC was also verified. This report suggests that in vivo, P. mirabilis UreD may be important for recruitment of UreF to the apourease and that crucial homomultimeric associations occur among these accessory proteins.
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- 2001
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25. Physical activity of urban adult population: questionnaire study.
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Misigoj-Duraković M, Heimer S, Matković BR, Ruzić L, and Prskalo I
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- Adult, Age Factors, Aged, Croatia, Educational Measurement, Female, Humans, Leisure Activities, Male, Middle Aged, Sex Factors, Surveys and Questionnaires, Urban Population, Exercise, Physical Fitness
- Abstract
Aim: To assess the level of physical activity of an urban population according to gender, age, smoking, and educational differences., Methods: The sample comprised 594 men and women living and working in Zagreb, Croatia. Work, sport, and leisure-time activity indices were obtained by the Baecke's questionnaire. Significance of differences was tested by the Student's t-test. The relation between the indices and the education was determined by correlation analysis., Results: Women had lower work and sport indices score, and higher leisure-time activity index. After the age of 50, women participated significantly more in sport activities than men. There was a negative correlation between the education and the work index, and a significantly positive correlation between the educational level and the sport activity index, regardless of gender and age. Women smokers participated to a significantly lesser extent in sport activities than women non-smokers. Such differences were not observed in men., Conclusion: People with lower educational level sustain more workload at their jobs than those with higher education. More educated people participate more in sport activities, although leisure time activity is not significantly related to education. In women, participation in sport activities negatively correlates with the smoking habit.
- Published
- 2000
26. [Active rest during work periods].
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Heimer S and Tonković-Lojović M
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- Fatigue prevention & control, Humans, Occupational Health, Rest, Work
- Abstract
Every work, especially professional work, induces fatigue which diminishes work efficacy. Active rests with aim-oriented recreational activities implemented in the work process are very efficacious in removing fatigue symptoms. The paper discusses examples and mechanisms of making work and recovery faster and more successful by programming physical activity at the beginning of work and during regular and added rests in accordance with the established critical time during the eight-hour work shift.
- Published
- 1994
27. [Scientific basis and professional concept of instituting a medical program of active recreation].
- Author
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Tonković-Lojović M, Heimer S, and Zuskin E
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- Humans, Exercise, Physical Fitness
- Abstract
Physical activity is essential to health and should be exercised in accordance with one's functional and health state. Among the most advanced forms of programmed physical activity is medically programmed active leisure (MPAL). The implementation of MPAL in practice relies on research and on scientifically based concepts and attitudes which control the selection of persons for and their inclusion in MPAL. In Croatia MPAL is a form of specific care for worker's health, which is conducted in compliance with the health care and health insurance acts.
- Published
- 1990
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