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2. Validation of machine learning models for estimation of left ventricular ejection fraction on point-of-care ultrasound: insights on features that impact performance

Author

Luong, Christina L., Jafari, Mohammad H., Behnami, Delaram, Shah, Yaksh R., Straatman, Lynn, Van Woudenberg, Nathan, Christoff, Leah, Gwadry, Nancy, Hawkins, Nathaniel M., Sayre, Eric C., Yeung, Darwin, Tsang, Michael, Gin, Ken, Jue, John, Nair, Parvathy, Abolmaesumi, Purang, and Tsang, Teresa

Published
2024
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11. Driving Restrictions and Early Arrhythmias in Patients Receiving a Secondary Prevention Implantable Cardioverter-Defibrillator (DREAM-ICD- II study)

Author

Steinberg, Christian, Dognin, Nicolas, Sodhi, Amit, Champagne, Catherine, Staples, John A., Champagne, Jean, Laksman, Zachary, Sarrazin, Jean-François, Bennett, Matthew, Plourde, Benoit, Deyell, Marc W., Andrade, Jason G., Roy, Karine, Yeung-Lai-Wah, John A., Hawkins, Nathaniel M., Mondésert, Blandine, Blier, Louis, Nault, Isabelle, O’Hara, Gilles, Krahn, Andrew D., Philippon, François, and Chakrabarti, Santabhanu

Published
2022
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16. EXAcerbations of COPD and their OutcomeS on CardioVascular diseases (EXACOS-CV) Programme: protocol of multicountry observational cohort studies

Author

Nordon, Clementine, primary, Rhodes, Kirsty, additional, Quint, Jennifer K, additional, Vogelmeier, Claus F, additional, Simons, Sami O, additional, Hawkins, Nathaniel M, additional, Marshall, Jonathan, additional, Ouwens, Mario, additional, Garbe, Edeltraut, additional, and Müllerová, Hana, additional

Published
2023
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22. The State of Heart Failure Care in Canada: Minimal Improvement in Readmissions Over Time Despite an Increased Number of Evidence-Based Therapies

Author

Poon, Stephanie, primary, Leis, Benjamin, additional, Lambert, Laurie, additional, MacFarlane, Kendra, additional, Anderson, Kim, additional, Blais, Claudia, additional, Demers, Catherine, additional, Ezekowitz, Justin A., additional, Hawkins, Nathaniel M., additional, Lee, Douglas S., additional, Moe, Gordon, additional, Sandhu, Roopinder K., additional, Virani, Sean A., additional, Wilton, Stephen, additional, Zieroth, Shelley, additional, and McKelvie, Robert, additional

Published
2022
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27. Healthcare utilization and quality of life for atrial fibrillation burden: the CIRCA-DOSE study.

Author

Andrade, Jason G, Deyell, Marc W, Macle, Laurent, Steinberg, Jonathan S, Glotzer, Taya V, Hawkins, Nathaniel M, Khairy, Paul, and Aguilar, Martin

Subjects
ATRIAL fibrillation, MEDICAL care, QUALITY of life, ELECTRIC countershock, ARRHYTHMIA
Abstract

Aims Atrial tachyarrhythmia recurrence ≥30 s remains the primary endpoint of clinical trials; however, this definition has not been correlated with clinical outcomes or pathophysiological processes. This study sought to determine the atrial tachyarrhythmia duration and burden associated with meaningful clinical outcomes. Methods and results The time and duration of every atrial tachyarrhythmia episode recorded on implantable cardiac monitor were evaluated. Healthcare utilization and quality of life in the year following ablation were prospectively collected. Three hundred and forty-six patients provided 126 110 monitoring days. One-year freedom from recurrence increased with arrhythmia duration thresholds, from 52.6 (182/346) to 93.3% (323/346; P < 0.0001). Patients with atrial fibrillation (AF) recurrence limited to durations ≤1 h had rates of healthcare utilization comparable with patients free of recurrence, while patients with AF recurrences lasting >1 h had a relative risk for emergency department consultation of 3.2 [95% confidence interval (CI) 2.0–5.3], hospitalization of 5.3 (95% CI 2.9–9.6), and repeat ablation of 27.1 (95% CI 10.5–71.0). Patients with AF burden of ≤0.1% had rates of healthcare utilization comparable with patients free of recurrence, while patients with AF burden of >0.1% had a relative risk for emergency department consultation of 2.4 (95% CI 1.9–3.9), hospitalization of 6.8 (95% CI 3.6–13.0), cardioversion of 9.1 (95% CI 3.3–25.6), and repeat ablation of 21.8 (95% CI 9.2–52.2). Compared with patients free of recurrence, the disease-specific quality of life was significantly impaired with AF episode durations >24 h, or AF burdens >0.1%. Conclusion AF recurrence, as defined by 30 s of arrhythmia, lacks clinical relevance. AF episode durations >1 h or burdens >0.1% were associated with increased rates of healthcare utilization. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Same-day discharge for atrial fibrillation ablation: outcomes and impact of ablation modality.

Author

Deyell, Marc W, Hoskin, Kurt, Forman, Jacqueline, Laksman, Zachary W, Hawkins, Nathaniel M, Bennett, Matthew T, Yeung-Lai-Wah, John A, Chakrabarti, Santabhanu, Krahn, Andrew D, and Andrade, Jason G

Abstract

Aims Same-day discharge is increasingly common after catheter ablation for atrial fibrillation (AF). However, the impact of same-day discharge on healthcare utilization after ablation and whether this differs by ablation modality remains uncertain. We examined the safety, efficacy, and subsequent healthcare utilization of a same-day discharge protocol for AF ablation, including radiofrequency (RF) and cryoballoon ablation, in a contemporary cohort. Methods and results All consecutive patients for whom full healthcare utilization data were available at two centres and who underwent AF ablation from 2018 to 2019 were included. Same-day discharge was the default strategy for all patients. The efficacy and safety outcomes were proportions of same-day discharge and readmission/emergency room (ER) visits, and post-discharge complications, respectively. Of the 421 patients who underwent AF ablation (mean 63.3 ± 10.2 years, 33% female), 90.5% (381/421) achieved same-day discharge with no difference between RF and cryoballoon ablation (89.8 vs. 95.1%, adjusted P = 0.327). Readmission ≤30 days occurred in 4.8%, with ER visits ≤30 days seen in 26.1% with no difference between ablation modalities (P = 0.634). Patients admitted overnight were more likely to present to the ER (40.0 vs. 24.7% with same-day discharge, P = 0.036). The overall post-discharge complication rate was low at 4/421 (1.0%), with no difference between ablation modality (P = 0.324) and admission/same-day discharge (P = 0.485). Conclusion Same-day discharge can be achieved in a majority of patients undergoing RF or cryoballoon ablation for AF. Healthcare utilization, particularly ER visits, remains high after AF ablation, regardless of ablation modality or same-day discharge. [ABSTRACT FROM AUTHOR]

Published
2023
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29. DREAM-ICD-II Study

Author

Steinberg, Christian, primary, Dognin, Nicolas, additional, Sodhi, Amit, additional, Champagne, Catherine, additional, Staples, John A., additional, Champagne, Jean, additional, Laksman, Zachary W., additional, Sarrazin, Jean-François, additional, Bennett, Matthew T., additional, Plourde, Benoit, additional, Deyell, Marc W., additional, Andrade, Jason G., additional, Roy, Karine, additional, Yeung-Lai-Wah, John A., additional, Hawkins, Nathaniel M., additional, Mondésert, Blandine, additional, Blier, Louis, additional, Nault, Isabelle, additional, O’Hara, Gilles, additional, Krahn, Andrew D., additional, Philippon, François, additional, and Chakrabarti, Santabhanu, additional

Published
2022
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30. Bluetooth-Enabled Implantable Cardiac Monitors and Two-Way Smartphone Communication for Patients With Hypertrophic Cardiomyopathy

Author

Safabakhsh, Sina, primary, Du, Darson, additional, Liew, Janet, additional, Parker, Jeremy, additional, McIlroy, Cheryl, additional, Khasanova, Elina, additional, Indraratna, Praveen, additional, Blanke, Philipp, additional, Leipsic, Jonathon, additional, Andrade, Jason G., additional, Bennett, Matthew T., additional, Hawkins, Nathaniel M., additional, Chakrabarti, Shantabanu, additional, Yeung, John, additional, Deyell, Marc W., additional, Krahn, Andrew D., additional, Moss, Robert, additional, Ong, Kevin, additional, and Laksman, Zachary, additional

Published
2022
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33. Impact of Chronic Obstructive Pulmonary Disease in Patients With Heart Failure With Preserved Ejection Fraction: Insights From PARAGON‐HF

Author

Mooney, Leanne, primary, Hawkins, Nathaniel M., additional, Jhund, Pardeep S., additional, Redfield, Margaret M., additional, Vaduganathan, Muthiah, additional, Desai, Akshay S., additional, Rouleau, Jean L., additional, Minamisawa, Masatoshi, additional, Shah, Amil M., additional, Lefkowitz, Martin P., additional, Zile, Michael R., additional, Van Veldhuisen, Dirk J., additional, Pfeffer, Marc A., additional, Anand, Inder S., additional, Maggioni, Aldo P., additional, Senni, Michele, additional, Claggett, Brian L., additional, Solomon, Scott D., additional, and McMurray, John J. V., additional

Published
2021
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35. Cryoballoon Ablation as Initial Treatment for Atrial Fibrillation

Author

Andrade, Jason G, Wazni, Oussama M, Kuniss, Malte, Hawkins, Nathaniel M, Deyell, Marc W, Chierchia, Gian-Battista, Nissen, Steven, Verma, Atul, Wells, George A, Turgeon, Ricky D, Clinical sciences, and Heartrhythmmanagement

Subjects
Cryotherapy, cryoballoon, Atrial Fibrillation, Catheter Ablation, Ablation, Cardiology and Cardiovascular Medicine, Antiarrhythmic drugs
Abstract

Atrial fibrillation (AF), the most common sustained arrhythmia observed in clinical practice, is a chronic and progressive disorder characterized by exacerbations and remissions. Guidelines recommend antiarrhythmic drugs as the initial therapy for the maintenance of sinus rhythm; however, antiarrhythmic drugs have modest efficacy to maintain sinus rhythm and can be associated with significant adverse effects. An initial treatment strategy of cryoballoon catheter ablation in patients with treatment-naïve AF has been shown to significantly improve arrhythmia outcomes (freedom from any, or symptomatic atrial tachyarrhythmia), produce clinically meaningful improvements in patient-reported outcomes (symptoms and quality of life), and significantly reduce subsequent health care resource use (hospitalization), and it does not increase the risk of serious or any adverse events compared with initial antiarrhythmic drug therapy. These findings are relevant to inform patients, providers, and health care systems regarding the initial choice of rhythm-control therapy in patients with treatment-naïve AF.

Published
2021

37. Development of Acute Myocardial Infarction Mortality and Readmission Models for Public Reporting on Hospital Performance in Canada

Author

Ko, Dennis T., primary, Ahmed, Tareq, additional, Austin, Peter C., additional, Cantor, Warren J., additional, Dorian, Paul, additional, Goldfarb, Michael, additional, Gong, Yanyan, additional, Graham, Michelle M., additional, Gu, Jing, additional, Hawkins, Nathaniel M., additional, Huynh, Thao, additional, Humphries, Karin H., additional, Koh, Maria, additional, Lamarche, Yoan, additional, Lambert, Laurie J., additional, Lawler, Patrick R., additional, Légaré, Jean-Francois, additional, Ly, Hung Q., additional, Qiu, Feng, additional, Quraishi, Ata ur Rehman, additional, So, Derek Y., additional, Welsh, Robert C., additional, Wijeysundera, Harindra C., additional, Wong, Graham, additional, Yan, Andrew T., additional, and Gurevich, Yana, additional

Published
2021
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38. Clinical characteristics and outcomes of patients with angina and heart failure in the CHARM (Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity) Programme

Author

Badar, Athar A., Perez-Moreno, Ana C., Hawkins, Nathaniel M., Brunton, Alan P.T., Jhund, Pardeep S., Wong, Chih M., Solomon, Scott D., Granger, Christopher B., Yusuf, Salim, Pfeffer, Marc A., Swedberg, Karl, Gardner, Roy S., Petrie, Mark C., and McMurray, John J.V.

Published
2015
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39. Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: an analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)

Author

Badar, Athar A., Perez-Moreno, Ana Cristina, Jhund, Pardeep S., Wong, Chih M., Hawkins, Nathaniel M., Cleland, John G.F., van Veldhuisen, Dirk J., Wikstrand, John, Kjekshus, John, Wedel, Hans, Watkins, Stuart, Gardner, Roy S., Petrie, Mark C., and McMurray, John J.V.

Published
2014
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40. Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)

Author

Wong, Chih M., Hawkins, Nathaniel M., Petrie, Mark C., Jhund, Pardeep S., Gardner, Roy S., Ariti, Cono A., Poppe, Katrina K., Earle, Nikki, Whalley, Gillian A., Squire, Iain B., Doughty, Robert N., McMurray, John J.V., Berry, C., Doughty, R., Granger, C., Køber, L., Massie, B., McAlister, F., McMurray, J., Pocock, S., Poppe, K., Swedberg, K., Somaratne, J., Whalley, G., Ahmed, A., Andersson, B., Bayes-Genis, A., Berry, C., Cowie, M., Cubbon, R., Doughty, R., Ezekowitz, J., Gonzalez-Juanatey, J., Gorini, M., Gotsman, I., Grigorian-Shamagian, L., Guazzi, M., Kearney, M., Køber, L., Komajda, M., di Lenarda, A., Lenzen, M., Lucci, D., Macín, S., Madsen, B., Maggioni, A., Martínez-Sellés, M., McAlister, F., Oliva, F., Poppe, K., Rich, M., Richards, M., Senni, M., Squire, I., Taffet, G., Tarantini, L., Tribouilloy, C., Troughton, R., Tsutsui, H., Whalley, G., Doughty, R., Earle, N., Gamble, G.D., Poppe, K., Whalley, G., Ariti, C., Dobson, J., Pocock, S., Poppe, K., Doughty, R.N., Whalley, G., Andersson, B., Hall, C., Richards, A.M., Troughton, R., Lainchbury, J., Berry, C., Hogg, K., Norrie, J., Stevenson, K., Brett, M., McMurray, J., Pfeffer, M.A., Swedberg, K., Granger, C.B., Held, P., McMurray, J.J.V., Michelson, E.L., Olofsson, B., Östergren, J., Yusuf, S., Køber, L., Torp-Pedersen, C., Ahmed, Ali, Lenzen, M.J., Scholte op Reimer, W.J.M., Boersma, E., Vantrimpont, P.J.M.J., Follath, F., Swedberg, K., Cleland, J., Komajda, M., Gotsman, I., Zwas, D., Planer, D., Azaz-Livshits, T., Admon, D., Lotan, C., Keren, A., Grigorian-Shamagian, L., Varela-Roman, A., Mazón-Ramos, P., Rigeiro-Veloso, P., Bandin-Dieguez, M.A., Gonzalez-Juanatey, J.R., Guazzi, M., Myers, J., Arena, R., McAlister, F.A., Ezekowitz, J., Armstrong, P.W., Cujec, Bibiana, Paterson, Ian, Cowie, M.R., Wood, D.A., Coats, A.J.S., Thompson, S.G., Suresh, V., Poole-Wilson, P.A., Sutton, G.C., Martínez-Sellés, M., Robles, J.A.G., Prieto, L., Muñoa, M.D., Frades, E., Díaz-Castro, O., Almendral, J., Tarantini, L., Faggiano, P., Senni, M., Lucci, D., Bertoli, D., Porcu, M., Opasich, C., Tavazzi, L., Maggioni, A.P., Kirk, V., Bay, M., Parner, J., Krogsgaard, K., Herzog, T.M., Boesgaard, S., Hassager, C., Nielsen, O.W., Aldershvile, J., Nielsen, H., Kober, L., Macín, S.M., Perna, E.R., Cimbaro Canella, J.P., Alvarenga, P., Pantich, R., Ríos, N., Farias, E.F., Badaracco, J.R., Madsen, B.K., Hansen, J.F., Stokholm, K.H., Brons, J., Husum, D., Mortensen, L.S., Bayes-Genis, A., Vazquez, R., Puig, T., Fernandez-Palomeque, C., Bardají, A., Pascual-Figal, D., Ordoñez-Llanos, J., Valdes, M., Gabarrus, A., Pavon, R., Pastor, L., Gonzalez-Juanatey, J.R., Almendral, J., Fiol, M., Nieto, V., Macaya, C., Cinca, J., Bayes de Luna, A., Newton, J.D., Blackledge, H.M., Squire, I.B., Wright, S.P., Whalley, G.A., Doughty, R.N., Kerzner, R., Gage, B.F., Freedland, K.E., Rich, M.W., Huynh, B.C., Rovner, A, Freedland, KE, Carney, RM, Rich, MW, Taffet, GE, Teasdale, T.A., Bleyer, A.J., Kutka, N.J., Luchi, R.J., Tribouilloy, C., Rusinaru, D., Mahjoub, H., Soulière, V., Lévy, F., Peltier, M., Tsutsui, H., Tsuchihashi, M., Takeshita, A., MacCarthy, P.A., Kearney, M.T., Nolan, J., Lee, A.J., Prescott, R.J., Shah, A.M., Brooksby, W.P., Fox, K.A.A., Varela-Roman, A., Gonzalez-Juanatey, J.R., Basante, P., Trillo, R., Garcia-Seara, J., Martinez-Sande, J.L., and Gude, F.

Published
2014
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45. Clinical Characteristics and Outcomes of Patients With Heart Failure With Reduced Ejection Fraction and Chronic Obstructive Pulmonary Disease: Insights From PARADIGM‐HF

Author

Ehteshami‐Afshar, Solmaz, primary, Mooney, Leanne, additional, Dewan, Pooja, additional, Desai, Akshay S., additional, Lang, Ninian N., additional, Lefkowitz, Martin P., additional, Petrie, Mark C., additional, Rizkala, Adel R., additional, Rouleau, Jean L., additional, Solomon, Scott D., additional, Swedberg, Karl, additional, Shi, Victor C., additional, Zile, Michael R., additional, Packer, Milton, additional, McMurray, John J. V., additional, Jhund, Pardeep S., additional, and Hawkins, Nathaniel M., additional

Published
2021
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46. Effects of dapagliflozin in heart failure with reduced ejection fraction and chronic obstructive pulmonary disease: an analysis of DAPA‐HF

Author

Dewan, Pooja, primary, Docherty, Kieran F., additional, Bengtsson, Olof, additional, Boer, Rudolf A., additional, Desai, Akshay S., additional, Drozdz, Jaroslaw, additional, Hawkins, Nathaniel M., additional, Inzucchi, Silvio E., additional, Kitakaze, Masafumi, additional, Køber, Lars, additional, Kosiborod, Mikail N., additional, Langkilde, Anna Maria, additional, Lindholm, Daniel, additional, Martinez, Felipe A., additional, Merkely, Béla, additional, Petrie, Mark C., additional, Ponikowski, Piotr, additional, Sabatine, Marc S., additional, Schou, Morten, additional, Sjöstrand, Mikaela, additional, Solomon, Scott D., additional, Verma, Subodh, additional, Jhund, Pardeep S., additional, and McMurray, John J.V., additional

Published
2021
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