1. A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis
- Author
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An-Qi Lu, Ming-Hua Chen, Jie Gao, Lu Wang, Han-Yu Yang, Lan Li, Bo Zhang, Hao-Ke He, and Su-Juan Wang
- Subjects
Cortex Mori Radicis ,Morus ,Diels-Alder adduct ,calculated ECD ,antioxidation ,Organic chemistry ,QD241-441 - Abstract
Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis. Its structure was established by spectroscopic analysis, including NMR and HR-MS (High Resolution Mass Spectrometry). Sanggenon X contained three O-bridged rings, where the oxygenated bridgeheads were all quaternary carbons. Chemical methylation was carried out to deduce the linkages of the three O-bridges. The absolute configuration was determined by calculating the ECD (Electronic Circular Dichroism) using the TDDFT (Time-Dependent Density Functional Theory) method. Sanggenon X showed significant antioxidant activity against Fe2+-Cys-induced lipid peroxidation in rat liver microsomes, and was as effective as the positive control, curcumin.
- Published
- 2018
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