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9 results on '"Hansdottir, Ingunn"'

1. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Author

Thorgeirsson, Thorgeir E., Geller, Frank, Sulem, Patrick, Rafnar, Thorunn, Wiste, Anna, Magnusson, Kristinn P., Manolescu, Andrei, Thorleifsson, Gudmar, Stefansson, Hreinn, Ingason, Andres, Stacey, Simon N., Bergthorsson, Jon T., Thorlacius, Steinunn, Gudmundsson, Julius, Jonsson, Thorlakur, Jakobsdottir, Margret, Saemundsdottir, Jona, Olafsdottir, Olof, Gudmundsson, Larus J., Bjornsdottir, Gyda, Kristjansson, Kristleifur, Skuladottir, Halla, Isaksson, Helgi J., Gudbjartsson, Tomas, Jones, Gregory T., Mueller, Thomas, Gottsäter, Anders, Flex, Andrea, Aben, Katja K. H., de Vegt, Femmie, Mulders, Peter F. A., Isla, Dolores, Vidal, Maria J., Asin, Laura, Saez, Berta, Murillo, Laura, Blondal, Thorsteinn, Kolbeinsson, Halldor, Stefansson, Jon G., Hansdottir, Ingunn, Runarsdottir, Valgerdur, Pola, Roberto, Lindblad, Bengt, van Rij, Andre M., Dieplinger, Benjamin, Haltmayer, Meinhard, Mayordomo, Jose I., Kiemeney, Lambertus A., Matthiasson, Stefan E., Oskarsson, Hogni, Tyrfingsson, Thorarinn, Gudbjartsson, Daniel F., Gulcher, Jeffrey R., Jonsson, Steinn, Thorsteinsdottir, Unnur, Kong, Augustine, and Stefansson, Kari

Published
2008
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3. 928. Major Decrease in Prevalence of Hepatitis C Viremia in Key Populations following the Second Year of Treatment as Prevention for Hepatitis C (TraP HepC) Program in Iceland

Author

Gottfredsson, Magnus, primary, Tyrfingsson, Thorarinn, additional, Runarsdottir, Valgerdur, additional, Hansdottir, Ingunn, additional, Bergmann, Ottar M, additional, Bjornsson, Einar S, additional, Johannsson, Birgir, additional, Sigurdardottir, Bryndis, additional, Fridriksdottir, Ragnheidur H, additional, Löve, Arthur, additional, Löve, Thorvardur J, additional, Sigmundsdottir, Gudrun, additional, Hernandez, Ubaldo, additional, Heimisdottir, Maria, additional, and Olafsson, Sigurdur, additional

Published
2018
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5. Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Author

Reginsson, Gunnar W., Ingason, Andres, Euesden, Jack, Bjornsdottir, Gyda, Olafsson, Sigurgeir, Sigurdsson, Engilbert, Oskarsson, Hogni, Tyrfingsson, Thorarinn, Runarsdottir, Valgerdur, Hansdottir, Ingunn, Steinberg, Stacy, Stefansson, Hreinn, Gudbjartsson, Daniel F., Thorgeirsson, Thorgeir E., Stefansson, Kari, Sálfræðideild (HÍ), Faculty of Psychology (UI), Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Verkfræði- og náttúruvísindasvið (HÍ), School of Engineering and Natural Sciences (UI), Háskóli Íslands, and University of Iceland

Subjects
Male, Risk, Substance abuse, Multifactorial Inheritance, Bipolar Disorder, Áfengissýki, Substance-Related Disorders, Iceland, Cigarette Smoking, Geðklofi, psychotic disorders, mental disorders, substance abuse, Odds Ratio, Humans, Aged, Aged, 80 and over, Psychotic disorders, Geðhvarfasýki, Fíkn, Genetic Study, Tobacco Use Disorder, Middle Aged, Polygenic scores, Tóbaksnotkun, polygenic scores, Alcoholism, Fíkniefnaneysla, Schizophrenia, Original Article, Female
Abstract

We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in‐patient addiction treatment and 35 754 smokers, we find that diagnoses of various substance use disorders and smoking associate strongly with PRSs for SCZ (P = 5.3 × 10−50–1.4 × 10−6) and BPD (P = 1.7 × 10−9–1.9 × 10−3), showing shared genetic etiology between psychosis and addiction. Using standardized scores for SCZ and BPD scaled to a unit increase doubling the risk of the corresponding disorder, the odds ratios for alcohol and substance use disorders range from 1.19 to 1.31 for the SCZ‐PRS, and from 1.07 to 1.29 for the BPD‐PRS. Furthermore, we show that as regular smoking becomes more stigmatized and less prevalent, these biological risk factors gain importance as determinants of the behavior., This study was funded in part by the National Institute on Drug Abuse (NIDA) (R01-DA017932 and R01-DA034076), and it received support from the European Community’s Seventh Framework Programme under the Marie Curie Industry Academia Partnership and Pathways (PsychDPC, GA 286213).

Published
2017
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6. Sixteen-year follow-up of childhood avalanche survivors

Author

Thordardottir, Edda Bjork, primary, Valdimarsdottir, Unnur Anna, additional, Hansdottir, Ingunn, additional, Hauksdóttir, Arna, additional, Dyregrov, Atle, additional, Shipherd, Jillian C., additional, Elklit, Ask, additional, Resnick, Heidi, additional, and Gudmundsdottir, Berglind, additional

Published
2016
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7. From paper to web: Mode equivalence of the ARHQ and NEO-FFI

Author

Bjornsdottir, Gyda, Almarsdottir, Anna B., Hansdottir, Ingunn, Thorsdottir, Fanney, Heimisdottir, Maria, Stefansson, Hreinn, Thorgeirsson, Thorgeir E., Brennan, Patricia F., Bjornsdottir, Gyda, Almarsdottir, Anna B., Hansdottir, Ingunn, Thorsdottir, Fanney, Heimisdottir, Maria, Stefansson, Hreinn, Thorgeirsson, Thorgeir E., and Brennan, Patricia F.

Published
2014

8. Psychometric properties of the Icelandic NEO-FFI in a general population sample compared to a sample recruited for a study on the genetics of addiction

Author

Bjornsdottir, Gyda, Jonsson, Fridrik H., Hansdottir, Ingunn, Almarsdottir, Anna B., Heimisdottir, Maria, Tyrfingsson, Thorarinn, Runarsdottir, Valgerdur A., Kristjansson, Kristleifur, Stefansson, Hreinn, Thorgeirsson, Thorgeir E., Bjornsdottir, Gyda, Jonsson, Fridrik H., Hansdottir, Ingunn, Almarsdottir, Anna B., Heimisdottir, Maria, Tyrfingsson, Thorarinn, Runarsdottir, Valgerdur A., Kristjansson, Kristleifur, Stefansson, Hreinn, and Thorgeirsson, Thorgeir E.

Abstract

Personality traits are major determinants of social behavior influencing various diseases including addiction. Twin and family studies suggest personality and addiction to be under genetic influence. Identification of DNA susceptibility variants relies on valid and reliable phenotyping approaches. We present results of psychometric testing of the Icelandic NEO-FFI in a population sample (N= 657) and a sample recruited for a study on addiction genetics (N= 3804). The Icelandic NEO-FFI demonstrated internal consistency and temporal stability. Factor analyses supported the five-factor structure. Icelandic norms were compared to American norms and language translations selected for geographical and cultural proximity to Iceland. Multiple discriminant function analysis using NEO-FFI trait scores and gender as independent variables predicted membership in recruitment groups for 47.3% of addiction study cases (N= 3804), with accurate predictions made for 69.5% of individuals with treated addiction and 43.3% of their first-degree relatives. Correlations between NEO-FFI scores and the discriminant function suggested a combination of high neuroticism, low conscientiousness and low agreeableness predicted membership in the Treated group.

Published
2014

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