6 results on '"Halvorsen CP"'
Search Results
2. Right Heart Structure, Geometry and Function Assessed by Echocardiography in 6-Year-Old Children Born Extremely Preterm-A Population-Based Cohort Study.
- Author
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Mohlkert LA, Hallberg J, Broberg O, Sjöberg G, Rydberg A, Liuba P, Fellman V, Domellöf M, Norman M, and Halvorsen CP
- Abstract
Preterm birth has been associated with altered cardiac phenotype in adults. Our aim was to test the hypothesis that children surviving extremely preterm birth have important structural or functional changes of the right heart or pulmonary circulation. We also examined relations between birth size, gestational age, neonatal diagnoses of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA) with cardiac outcomes. We assessed a population-based cohort of children born in Sweden before 27 weeks of gestation with echocardiography at 6.5 years of age ( n = 176). Each preterm child was matched to a healthy control child born at term. Children born preterm had significantly smaller right atria, right ventricles with smaller widths, higher relative wall thickness and higher estimated pulmonary vascular resistance (PVR) than controls. In preterm children, PVR and right ventricular myocardial performance index (RVmpi') were significantly higher in those with a PDA as neonates than in those without PDA, but no such associations were found with BPD. In conclusion, children born extremely preterm exhibit higher estimated PVR, altered right heart structure and function compared with children born at term., Competing Interests: The authors declare no conflict to disclose.
- Published
- 2020
- Full Text
- View/download PDF
3. A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care.
- Author
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Halvorsen CP, Olson L, Araújo AC, Karlsson M, Nguyễn TT, Khu DTK, Le HTT, Nguyễn HTB, Winbladh B, and Russom A
- Subjects
- Calibration, Colorimetry, Fetal Blood, Humans, Hypoxia, Infant, Newborn, Ischemia, Mobile Applications, Prothrombin Time, Reference Standards, Reference Values, Reproducibility of Results, Software, Sweden, L-Lactate Dehydrogenase blood, Neonatal Screening instrumentation, Point-of-Care Testing, Smartphone
- Abstract
There is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-in-result-out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson's correlation test was 0.91 (p < 0.01) and the R
2 = 0.83 between the two methods. The mean LDH (±SD) for the reference method vs. the POC-LDH was 551 (±280) U/L and 552 (±249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.- Published
- 2019
- Full Text
- View/download PDF
4. The Preterm Heart in Childhood: Left Ventricular Structure, Geometry, and Function Assessed by Echocardiography in 6-Year-Old Survivors of Periviable Births.
- Author
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Mohlkert LA, Hallberg J, Broberg O, Rydberg A, Halvorsen CP, Liuba P, Fellman V, Domellöf M, Sjöberg G, and Norman M
- Subjects
- Age Factors, Case-Control Studies, Child, Diastole, Female, Gestational Age, Heart Ventricles physiopathology, Humans, Male, Phenotype, Predictive Value of Tests, Prognosis, Prospective Studies, Systole, Time Factors, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Left physiopathology, Echocardiography, Doppler, Heart Ventricles diagnostic imaging, Infant, Extremely Premature, Premature Birth, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Function, Left
- Abstract
Background: Preterm birth has been associated with increased risk of cardiovascular morbidity in adult life. We evaluated whether preterm birth is associated with deviating cardiac structure and function before school start., Methods and Results: In total, 176 children aged 6 years and born extremely preterm (EXPT; gestational age of 22-26 weeks) and 134 children born at term (control [CTRL]) were studied. We used echocardiography to assess left heart dimensions, geometry, and functions. Recording and off-line analyses of echocardiographic images were performed by operators blinded to group belonging. Body size, blood pressure, and heart rate were also measured. Rates of family history of cardiovascular disease and sex distribution were similar in the EXPT and CTRL groups. Heart rate and systolic blood pressure did not differ, whereas diastolic blood pressure was slightly higher in EXPT than CTRL participants. After adjusting for body surface area, left ventricular length, width, and aortic valve annulus diameter were 3% to 5% smaller in EXPT than CTRL participants. Left ventricular longitudinal shortening and systolic tissue velocity were 7% to 11% lower, and transversal shortening fraction was 6% higher in EXPT than CTRL participants. The EXPT group also exhibited lower atrial emptying velocities than the CTRL group. Sex, fetal growth restriction, or a patent ductus arteriosus in the neonatal period did not contribute to cardiac dimensions or performance., Conclusions: Six-year-old children born extremely preterm exhibit a unique cardiac phenotype characterized by smaller left ventricles with altered systolic and diastolic functions than same-aged children born at term., (© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.)
- Published
- 2018
- Full Text
- View/download PDF
5. [Twin transfusion: with treatment good survival].
- Author
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Halvorsen CP and Ek S
- Subjects
- Female, Fetoscopy methods, Humans, Pregnancy, Risk Factors, Treatment Outcome, Fetal Therapies methods, Fetofetal Transfusion diagnosis, Fetofetal Transfusion mortality, Fetofetal Transfusion surgery, Laser Coagulation methods
- Published
- 2010
6. Discordant twin growth in utero and differences in blood pressure and endothelial function at 8 years of age.
- Author
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Halvorsen CP, Andolf E, Hu J, Pilo C, Winbladh B, and Norman M
- Subjects
- Acetylcholine, Aorta, Abdominal diagnostic imaging, Brachial Artery diagnostic imaging, Brachial Artery drug effects, Carotid Arteries diagnostic imaging, Child, Endothelium, Vascular diagnostic imaging, Endothelium, Vascular drug effects, Female, Fetal Development, Follow-Up Studies, Humans, Laser-Doppler Flowmetry, Male, Nitroglycerin, Skin blood supply, Twins, Dizygotic, Twins, Monozygotic, Ultrasonography, Vasodilator Agents, Blood Pressure, Brachial Artery physiopathology, Diseases in Twins physiopathology, Endothelium, Vascular physiopathology, Fetal Growth Retardation physiopathology
- Abstract
Objective: Low birth weight is associated with increased prevalence of hypertension and cardiovascular disease in adults. The aim of this study was to evaluate genetic and intrauterine environmental contributions to blood pressure (BP) and vascular functions in twins with discordant growth in utero., Subjects: We studied 31 twin pairs (21 monozygous and nine dizygous), mean age 8 years) with large within-pair differences in birth weight. Among the monozygous pairs, nine had suffered from twin-to-twin-transfusion syndrome (TTTS)., Methods: Apart from BP, we determined diameters and elasticity of the carotid artery and abdominal aorta with ultrasonography, and endothelial function in skin vessels with a laser Doppler technique, before and after transdermal delivery of acetylcholine and nitroglycerin., Results: Eight of 62 twin subjects had a systolic BP above the 90th percentile in a North-American reference population. Among these, seven/eight were monozygous with a history of poor fetal growth and/or TTTS. In monozygous twin pairs without TTTS, systolic BP and pulse pressure were higher and vascular endothelial function was impaired in the lower birth weight twin. In the TTTS group, the lighter twin had a narrower carotid artery but there was no within-pair difference in arterial elasticity. Pre-eclampsia during the index pregnancy enhanced within-pair differences in BP but abolished within-pair differences in endothelial function., Conclusions: Severe fetal growth retardation contributes to higher BP, arterial narrowing and endothelial dysfunction in childhood. Pre-eclampsia may act both as an effect modifier and confounder of these associations.
- Published
- 2006
- Full Text
- View/download PDF
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