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9 results on '"Halmos, György B."'

1. Fewer head and neck cancer diagnoses and faster treatment initiation during COVID-19 in 2020: A nationwide population-based analysis: Impact of COVID-19 on head and neck cancer

Author

Schoonbeek, Rosanne C., de Jel, Dominique V. C., van Dijk, Boukje A. C., Willems, Stefan M., Bloemena, Elisabeth, Hoebers, Frank J. P., van Meerten, Esther, Verbist, Berit M., Smeele, Ludi E., Halmos, György B., Merkx, Matthias A. W., Siesling, Sabine, de Bree, Remco, Takes, Robert P., Medical Oncology, TechMed Centre, Health Technology & Services Research, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, Oral and Maxillofacial Surgery, and CCA - Cancer Treatment and Quality of Life

Subjects
Delay, Time-to-treatment, SDG 3 - Good Health and Well-being, COVID-19, Head and neck cancer, Cancer incidence
Abstract

Background: Inevitably, the emergence of COVID-19 has impacted non-COVID care. Because timely diagnosis and treatment are essential, especially for patients with head and neck cancer (HNC) with fast-growing tumours in a functionally and aesthetically important area, we wished to quantify the impact of the COVID-19 pandemic on HNC care in the Netherlands. Material and Methods: This population-based study covered all, in total 8468, newly diagnosed primary HNC cases in the Netherlands in 2018, 2019 and 2020. We compared incidence, patient and tumour characteristics, primary treatment characteristics, and time-to-treatment in the first COVID-19 year 2020 with corresponding periods in 2018 and 2019 (i.e. pre-COVID). Results: The incidence of HNC was nearly 25% less during the first wave (n = 433) than in 2019 (n = 595) and 2018 (n = 598). In April and May 2020, the incidence of oral cavity and laryngeal carcinomas was significantly lower than in pre-COVID years. There were no shifts in tumour stage or alterations in initial treatment modalities. Regardless of the first treatment modality and specific period, the median number of days between first visit to a HNC centre and start of treatment was significantly shorter during the COVID-19 year (26–28 days) than pre-COVID (31–32 days, p < 0.001). Conclusion: The incidence of HNC during the Netherlands’ first COVID-19 wave was significantly lower than expected. The expected increase in incidence during the remainder of 2020 was not observed. Despite the overloaded healthcare system, the standard treatment for HNC patients could be delivered within a shorter time interval.

Published
2022

2. Fewer head and neck cancer diagnoses and faster treatment initiation during COVID-19 in 2020:A nationwide population-based analysis: Impact of COVID-19 on head and neck cancer

Author

Schoonbeek, Rosanne C., de Jel, Dominique V.C., van Dijk, Boukje A.C., Willems, Stefan M., Bloemena, Elisabeth, Hoebers, Frank J.P., van Meerten, Esther, Verbist, Berit M., Smeele, Ludi E., Halmos, György B., Merkx, Matthias A.W., Siesling, Sabine, De Bree, Remco, Takes, Robert P., Schoonbeek, Rosanne C., de Jel, Dominique V.C., van Dijk, Boukje A.C., Willems, Stefan M., Bloemena, Elisabeth, Hoebers, Frank J.P., van Meerten, Esther, Verbist, Berit M., Smeele, Ludi E., Halmos, György B., Merkx, Matthias A.W., Siesling, Sabine, De Bree, Remco, and Takes, Robert P.

Abstract

Background: Inevitably, the emergence of COVID-19 has impacted non-COVID care. Because timely diagnosis and treatment are essential, especially for patients with head and neck cancer (HNC) with fast-growing tumours in a functionally and aesthetically important area, we wished to quantify the impact of the COVID-19 pandemic on HNC care in the Netherlands. Material and Methods: This population-based study covered all, in total 8468, newly diagnosed primary HNC cases in the Netherlands in 2018, 2019 and 2020. We compared incidence, patient and tumour characteristics, primary treatment characteristics, and time-to-treatment in the first COVID-19 year 2020 with corresponding periods in 2018 and 2019 (i.e. pre-COVID). Results: The incidence of HNC was nearly 25% less during the first wave (n = 433) than in 2019 (n = 595) and 2018 (n = 598). In April and May 2020, the incidence of oral cavity and laryngeal carcinomas was significantly lower than in pre-COVID years. There were no shifts in tumour stage or alterations in initial treatment modalities. Regardless of the first treatment modality and specific period, the median number of days between first visit to a HNC centre and start of treatment was significantly shorter during the COVID-19 year (26–28 days) than pre-COVID (31–32 days, p < 0.001). Conclusion: The incidence of HNC during the Netherlands’ first COVID-19 wave was significantly lower than expected. The expected increase in incidence during the remainder of 2020 was not observed. Despite the overloaded healthcare system, the standard treatment for HNC patients could be delivered within a shorter time interval.

Published
2022

3. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy:Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Abstract

Objectives: The guided self-help exercise program called In Tune without Cords (ITwC) is effective in improving swallowing problems and communication among patients treated with a total laryngectomy (TL). This study investigated the cost-utility and cost-effectiveness of ITwC. Materials and methods: Patients within 5 years after TL were included in this randomized controlled trial. Patients in the intervention group (n = 46) received access to the self-help exercise program with flexibility, range-of-motion and lymphedema exercises, and a self-care education program. Patients in the control group (n = 46) received access to the self-care education program only. Healthcare utilization (iMCQ), productivity losses (iPCQ), health status (EQ-5D-3L, EORTC QLU-C10D) and swallowing problems (SwalQol) were measured at baseline, 3- and 6-months follow-up. Hospital costs were extracted from medical files. Mean total costs and effects (quality-adjusted life-years (QALYs) or SwalQol score) were compared with regression analyses using bias-corrected accelerated bootstrapping. Results: Mean total costs were non-significantly lower (-€685) and QALYs were significantly higher (+0.06) in the intervention compared to the control group. The probability that the intervention is less costly and more effective was 73%. Sensitivity analyses with adjustment for baseline costs and EQ-5D scores showed non-significantly higher costs (+€119 to +€364) and QALYs (+0.02 to +0.03). A sensitivity analysis using the QLU-C10D to calculate QALYs showed higher costs (+€741) and lower QALYs (-0.01) and an analysis that used the SwalQol showed higher costs (+€232) and higher effects (improvement of 6 points on a 0–100 scale). Conclusion: ITwC is likely to be effective, but possibly at higher expenses. Trial Registration: NTR5255.

Published
2021

4. Cost-utility and cost-effectiveness of a guided self-help head and neck exercise program for patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, Verdonck-de Leeuw, Irma M., Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Coupé, Veerle M.H., Eerenstein, Simone E.J., Cnossen, Ingrid C., van Uden-Kraan, Cornelia F., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2021

5. Effectiveness of a guided self-help exercise program tailored to patients treated with total laryngectomy : Results of a multi-center randomized controlled trial

Author

Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2020

6. Effectiveness of a guided self-help exercise program tailored to patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, Verdonck-de Leeuw, Irma M., MS Hoofd-Hals Chirurgische Oncologie, Cancer, MS Radiotherapie, Jansen, Femke, Eerenstein, Simone E.J., Cnossen, Ingrid C., Lissenberg-Witte, Birgit I., de Bree, Remco, Doornaert, Patricia, Halmos, György B., Hardillo, José A.U., van Hinte, Gerben, Honings, Jimmie, van Uden-Kraan, Cornelia F., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2020

7. Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy : Protocol of a multi-center randomized controlled trial

Author

Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, Verdonck-de Leeuw, Irma M., Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2016

8. Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: Protocol of a multi-center randomized controlled trial

Author

MS Radiotherapie, Divisie Beeld & Oncologie, MS KNO, Other research (not in main researchprogram), MS Hoofd-Hals Chirurgische Oncologie, Cancer, Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, Verdonck-de Leeuw, Irma M., MS Radiotherapie, Divisie Beeld & Oncologie, MS KNO, Other research (not in main researchprogram), MS Hoofd-Hals Chirurgische Oncologie, Cancer, Jansen, Femke, Cnossen, Ingrid C., Eerenstein, Simone E J, Coupé, Veerle M H, Witte, Birgit I., van Uden-Kraan, Cornelia F., Doornaert, Patricia, Braunius, Weibel W., De Bree, Remco, Hardillo, José A U, Honings, Jimmie, Halmos, György B., Leemans, C. René, and Verdonck-de Leeuw, Irma M.

Published
2016

9. Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: protocol of a multi-center randomized controlled trial

Author

Jansen, Femke, primary, Cnossen, Ingrid C., additional, Eerenstein, Simone E. J., additional, Coupé, Veerle M. H., additional, Witte, Birgit I., additional, van Uden-Kraan, Cornelia F., additional, Doornaert, Patricia, additional, Braunius, Weibel W., additional, De Bree, Remco, additional, Hardillo, José A. U., additional, Honings, Jimmie, additional, Halmos, György B., additional, Leemans, C. René, additional, and Verdonck-de Leeuw, Irma M., additional

Published
2016
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