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56 results on '"H. Grimes"'

1. Year-Long Stability of Nucleic Acid Bases in Concentrated Sulfuric Acid: Implications for the Persistence of Organic Chemistry in Venus’ Clouds

Author: Sara Seager, Janusz J. Petkowski, Maxwell D. Seager, John H. Grimes, Zachary Zinsli, Heidi R. Vollmer-Snarr, Mohamed K. Abd El-Rahman, David S. Wishart, Brian L. Lee, Vasuk Gautam, Lauren Herrington, William Bains, and Charles Darrow
Subjects: Venus, NMR, nucleic acid bases, sulfuric acid, Science
Abstract: We show that the nucleic acid bases adenine, cytosine, guanine, thymine, and uracil, as well as 2,6-diaminopurine, and the “core” nucleic acid bases purine and pyrimidine, are stable for more than one year in concentrated sulfuric acid at room temperature and at acid concentrations relevant for Venus clouds (81% w/w to 98% w/w acid, the rest water). This work builds on our initial stability studies and is the first ever to test the reactivity and structural integrity of organic molecules subjected to extended incubation in concentrated sulfuric acid. The one-year-long stability of nucleic acid bases supports the notion that the Venus cloud environment—composed of concentrated sulfuric acid—may be able to support complex organic chemicals for extended periods of time.
Published: 2024
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2. Retrospective Planning Study of Patients with Superior Sulcus Tumours Comparing Pencil Beam Scanning Protons to Volumetric-Modulated Arc Therapy

Author: R. Mendes, A. Poynter, Sarah L. Gulliford, R.A. Sharma, Z. Liao, J. Alshaikhi, V. Rompokos, Gary Royle, S. Wong, Richard A. Amos, and H. Grimes
Subjects: Organs at Risk, Lung Neoplasms, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Planning study, non-small cell lung, medicine, Proton Therapy, Humans, Radiology, Nuclear Medicine and imaging, Spinal canal, Stage (cooking), Pencil-beam scanning, Proton therapy, Retrospective Studies, business.industry, Radiotherapy Planning, Computer-Assisted, Carcinoma, Radiotherapy Dosage, Sulcus, Volumetric modulated arc therapy, X-ray therapy, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Thoracic vertebrae, Original Article, Radiotherapy, Intensity-Modulated, Protons, Nuclear medicine, business
Abstract: Aims Twenty per cent of patients with non-small cell lung cancer present with stage III locally advanced disease. Precision radiotherapy with pencil beam scanning (PBS) protons may improve outcomes. However, stage III is a heterogeneous group and accounting for complex tumour motion is challenging. As yet, it remains unclear as to whom will benefit. In our retrospective planning study, we explored if patients with superior sulcus tumours (SSTs) are a select cohort who might benefit from this treatment. Materials and methods Patients with SSTs treated with radical radiotherapy using four-dimensional planning computed tomography between 2010 and 2015 were identified. Tumour motion was assessed and excluded if greater than 5 mm. Photon volumetric-modulated arc therapy (VMAT) and PBS proton single-field optimisation plans, with and without inhomogeneity corrections, were generated retrospectively. Robustness analysis was assessed for VMAT and PBS plans involving: (i) 5 mm geometric uncertainty, with an additional 3.5% range uncertainty for proton plans; (ii) verification plans at maximal inhalation and exhalation. Comparative dosimetric and robustness analyses were carried out. Results Ten patients were suitable. The mean clinical target volume D95 was 98.1% ± 0.4 (97.5–98.8) and 98.4% ± 0.2 (98.1–98.9) for PBS and VMAT plans, respectively. All normal tissue tolerances were achieved. The same four PBS and VMAT plans failed robustness assessment. Inhomogeneity corrections minimally impacted proton plan robustness and made it worse in one case. The most important factor affecting target coverage and robustness was the clinical target volume entering the spinal canal. Proton plans significantly reduced the mean lung dose (by 21.9%), lung V5, V10, V20 (by 47.9%, 36.4%, 12.1%, respectively), mean heart dose (by 21.4%) and thoracic vertebra dose (by 29.2%) (P, Highlights • Robust scanning proton plans are feasible in patients with superior sulcus tumours. • Target coverage is comparable to volumetric-modulated arc therapy plans. • Considerable dose reduction to the thoracic vertebra, lungs and heart is possible. • Using an inhomogeneity correction did not improve robustness. • The same proton and photon plans failed robustness assessment.
Published: 2021

3. BJS commission on surgery and perioperative care post-COVID-19

Author: E. Abahuje, A. Abbas, M. Abd El Aziz Abd El Maksoud, A. Abdelhady, S. Abdelhamid, H. Abdelkarem Ahmed Faraj, B. Abdelqader, T. Abdelrahman, H. Abdou, A. Abdullah, M. Abedua Harrison, E. Abem Owusu, A. Aboalazayem, R. Aboulhosn, S. Abu Oda, A. Abubakar, A. Abutaka, D. Acevedo Fontalvo, S. Acuna, A. Adefemi, S. Adegbola, T. Adenuga, A. Adeyeye, A. Adil Hilmi, A. Adisa, K. Aditya, T. Adjeso, R. Aftab, A. Afzal, V. Aggarwal, A. Aggarwal, R. Aguilera, M. -L. Aguilera-Are´valo, E. J. Aguirre Salamanca, I. Aguirre-Allende, D. Ahari, H. Ahmad, F. Ahmad Rauf, A. Ahmad Zartasht Khan, S. Ahmed, N. Ahmed Fieturi, S. Ahmed Mohamed, Z. Ahmed-Bakhsh, M. Ahsan Javed, L. Akano, A. Akbar, M. Akhbari, P. Akhmedov, G. Aksit, Y. Akula, A. S. Alagaratnam, S. Al Majid, O. Al Mukhtar, H. Al Omran, N. AlAsali, M. Al-Azzawi, R. Al-Habsi, H. Al-Iraqi, H. Al-Naggar, E. Alameer, H. Albirnawi, D. Alderson, F. Aldulaijan, R. Alejandro Miranda Ojeda, A. AlHasan, S. Ali, A. Ali, M. Ali Khan, Y. Alimova, F. Aljanadi, R. Aljubure, N. Allopi, H. Almedbal, M. Almubarak, Z. Alqaidoom, N. Alselaim, M. Alshaar, R. Alshammari, K. Altaf, S. Altıner, B. Altunpak, L. A. Alvarez Lozada, E. Amal Nahal, A. Amer, K. Amin, U. Aminu, N. Amisi Numbi, T. Amjad, R. Amoah, Y. An, N. -A. Anastasopoulos, J. Andre´s Urrutia, F. Angarita, K. -L. Angarita, M. A´ ngel FreirI´a Eiras, A. Antypas, M. A. Anwar, H. Anwar, T. O. Apampa, K. Apostolou, C. Aquina, R. Arachchige Adithi Himika Randeni, M. I. Archila Godı´nez, O. Arez, A. A. Arezzo, P. Armonis, S. Arshad, M. Arshad Salman, A. Arshid, P. C. Arteaga Asensio, T. Arthur, A. Arumuga Jothi, F. Aryo Damara, L. Asensio Gomez, J. Ashcroft, S. Ashraf, A. Asif, M. Atif, M. Attaullah Khan, N. Avellaneda, S. Awad, M. Awadh, A. Axiaq, A. Ayad Mohammed Shuwayyah, D. Ayalew, E. Aytac, F. Azam, J. Azevedo, B. Azhar, J. Aziz, A. Aziz, A. Azzam, A. Baba Ndajiwo, M. Baig, D. Baker, F. Bakko, R. Balachandran, G. Balachandran, J. Balagizi Mudekereza, E. Balai, B. Balci, A. Balduzzi, A. Balhareth, S. Bandyopadhyay, D. Banerjee, D. Bangalore Mahalinga, B. Bankhead-Kendall, N. D. A. Bankole, V. Banwell, F. Baris Bengur, B. Baris Ozmen, M. Barnard, R. Barnett, J. A. Barreras Espinoza, A. Barrios, G. Bass, M. Bass, A. Bausys, A. Bavikatte, J. Bayram, M. Belousov, A. G. Berardi, A. Beamish, C. Beattie, F. Belia, V. Bellato, S. Bellikatti, S. Benjamens, C. Benlice, S. Bennedsgaard, S. Bennett, Z. Bentounsi, H. Bergenfeldt, A. Bergenfelz, M. Besselink, G. Bhandoria, E. Bhangu, M. Bhatia, M. T. Bhatti, Z. Bilgili, G. Bislenghi, C. Bisset, S. Biswas, J. Blake, R. Blanco, L. Boccalatte, R. Boden, C. Bojanic, M. Boland, P. Boland, E. Bollen, E. -A. Bonci, L. Boni, A. Booth, R. Booth, A. Borakati, G. E. Borunda Escudero, S. J. Bosco, P. Bostro¨ m, P. Botelho de Alencar Ferreira Cruz, K. Bouchagier, A. Bouhuwaish, M. Boutros, K. Boyce, C. Boyle, L. Bradshaw, A. Brandl, A. Brar, G. Brat, H. Brenkman, C. Brennan, C. Brines, A. Brookmyre, C. Brosnan, L. Brouwers, A. Brown, L. Brown, C. Brown, J. Brown, V. BS, M. Buksh, M. Bunani Emmanuel, D. Burbano, A. Burelli, A. Burke, J. Burke, N. Burlov, A. Burns, O. Burton, A. Butt, B. Buzra Ozkan, L. Cabrera Silva, E. Y. Caicedo, T. Calderbank, W. Cambridge, G. Campelo, O. Can Tatar, F. Carbone, F. Carrano, D. Casallas, D. Casanova Portoles, F. Casciani, I. Cassimjee, O. A. Castaneda Ramı´rez, V. Catala´ n, J. Caviedes, L. Cayetano, M. ~ Ceresoli, M. Chan, V. Chan, P. Chandrasinghe, S. Chapman, A. Chaturvedi, D. Chaudhry, H. Chaudry, H. W. Chen, A. Cheng, M. Chernykh, A. M. Cherrie, I. Cheruiyot, J. Cheung, C. Chia, J. Chica, N. Chinai, A. Chirwa, J. Chiwaligo, A. Choi, J. Choi, M. R. Chowdhury, E. Christopher, N. Christou, T. Chu, D. Chua, H. W. Chua, C. Chung, A. Cihat Yildirim, M. Cillo, S. Cioffi, H. Claireaux, S. Clermonts, R. Clifford, M. Climent, A. Clynch, R. -J. Coelen, E. Cola´ s-Ruiz, A. Collar, M. Collard, K. C. Conlon, T. Connelly, K. Connor, J. A. Cook, T. Correia de Sa´, N. Cos¸gun Acar, T. Costa, D. Couch, S. Cowper, B. Creavin, B. Crook, A. Curell, R. D’alessio, J. Dale, J. Damgaard Eriksen, I. Dario Martin Gonzalez, A. Darwish, M. Das, R. Das, K. Das, R. Dave, S. O. David, T. Davies, C. Davis, S. Davison, V. Davletshina, A. Dawidziuk, A. Dawson, M. de Andres Crespo, H. de Berker, P. de Dieu Ngo, E. Dekker, R. de la Caridad Espinosa Luis, B. de Lacy, N. Demartines, A. de Montserrat Medina Sifuentes, S. De Silva, C. del Rio, V. Delaune, A. Dell, I. Demirbas¸, S. Demirli Atici, M. Deniz Tepe, M. Derebey, G. Desai, M. Desai, S. Devarakonda, N. Deveras, G. Di Franco, M. Di Martino, F. Di Marzo, A´ . Dı´az, G. Diaz del Gobbo, C. DiazCastrillon, L. Dick, K. Dickinson, E. Diego, I. Dimasi, A. Ding, S. Dingemans, L. Dixon, B. Dixon, W. Doherty, D. Dooreemeah, C. Donohue, M. Dornseifer, F. Dossa, W. Dossou, T. Drake, I. Drami, G. Drevin, M. C. du Plessis, N. Dudi-Venkata, R. Dudley, S. Duffy, D. Duklas, B. -D. Dumbrava, F. Duygu Avlar, A. Dworzynska, W. Ebrahim, A. Ebrahim, E. Efre´n Lozada Herna´ ndez, N. Ehigie, M. El Boghdady, C. El Hasnaoui, M. El Sheikh, A. El-Hussuna, O. Eldurssi, H. Elfeki, M. Elhadi, M. Elhassan, A. Elhissi, B. Elliot, C. Elsenbroek, B. Elsolh, N. Elson, H. Eltyeb, H. Emerson, S. H. Emile, G. Endalle, W. English, C. Ercisli, G. Espinosa, M. Essam Abdelraheem, H. Essangri, P. Etienne, M. D. Evans, T. Evans, C. Ezeme, F. Ezzahraa, T. Fadalla, J. Fagan, M. Fahmy, C. Fairfield, O. Falade, S. Famularo, F. Faqar-Uz-Zaman, Y. Farid, A. Farooq, H. Farooq, F. Farooqui, B. Farquharson, A. Faruqi, R. Faulder, M. Faut, K. Fechner, T. Feenstra, M. Fehervari, L. Fernandez, J. Ferna´ ndez Alberti, L. Ferrario, D. Field, L. Fiore, S. Fingerhut, S. Finlayson, N. Fleming, C. Fleming, E. Florial, M. Fok, D. Fokin, M. Foley, M. P. Forero, T. Forgan, M. Fornasiero, H. Fowler, G. Fowler, E. Franchi, L. Franklin, A˚ . Fredriksson, P. Fruhling, G. Fuentes Navarrette, A. Fu¨ lo¨ p, M. Furtado, T. Gaarder, N. Galbraith, I. T. K. Gallagher, G. Gallo, T. Gana, E. Gaskin, M. Gasparini, R. G. Gatan, E. Geary, K. Gelaye Wudineh, G. Gemenetzis, M. Georgi, H. Ghalige, W. Ghareeb, T. Ghatwary Tantawy, C. Ghomsi, A. Ghuman, P. Giannakis, F. Giron, K. Gjengedal, E. Gkotsis, J. Glasbey, S. Godahewa, D. Godula, P. Goffredo, S. Goh, M. Golriz, L. Gomez, D. Gomez Gomez, R. Gonzalez, D. Gonzalez, E. Gonzalez Gutierrez, D. Gopar, L. Gordini, A. Gori, S. Gorta´ zar, N. Gousy, R. Gowda, M. Gowda, J. Gqada, M. Grechenig, J. Greer, L. Grego´ rio, A. Grigorova, H. Grimes, V. Groot, R. C. Grossman, R. Gruber, A. Gru¨ ter, R. Guest, R. Gujjuri, E. Gu¨ lc¸ek, B. Gulcu, K. Gull, M. Gulmez, V. Gupta, A. Gutlic, T. Guven, T. Gwatirisa, G. Gwini, P. Gwodog, S. Gysling, M. Habib, A. B. Hafeez Bhatti, J. Hallesmith, S. Halloran, M. Hamza Sadiq, C. Haney, N. Hanna, L. Hanna, M. Hannington, J. Harbjerg, D. Haribaskaran, N. Harran, B. Harrington, E. Harrison, R. Hasan, S. Hashmi, M. Hassan, A. Hassan, L. Haverkamp, S. Hazen, B. Heer, J. Heil, J. Helliwell, N. Henriksen, D. Henshall, M. Hermanson, S. Hermena, D. Hettiarachchi, C. Hextall, M. Hidalgo, H. Hidayat, A. Hider, P. Higgins, R. Hinchliffe, D. Hirani, D. Hirpara, I. Hisham, M. Hite, S. M. Hoh, C. Holmberg, E. Ho¨ lmich, F. Holst, A. Hossam, A. Hossam Elfallal, P. Howard, E. Huaman, Y. Huang, L. Huang, D. Huang, T. Huber, J. Hugh, J. Hughes, F. Hu¨ ttner, R. Huynh, A. Hylands, J. Iannuzzi, B. Ielpo, A. Iftikhar Talib, J. Ignacio, P. Ignatavicius, S. Ike, C. Ikwu, M. Inama, A. Ing, A. Ingels, A. Isik, N. Islam, I. J. Ives, A. J. M. S. AlHasan, C. J. Perez Rivera, F. Ja´ come, T. Jaffer, O. Jagiella-Lodise, M. Jain, K. Jain, M. Jakubauskas, M. Jalal, H. James, Y. Jang, B. Janssen, H. Jansson, U´ . Jariod-Ferrer, H. Javanmard, S. Javed, U. Jayarajah, I. Jayasuriya, J. Je, Z. Jessop, E. Jia Lin Tang, H. Jiang, Y. Jiayan, T. Jih Huei, R. Jimenez-Rodriguez, D. Joh, A. Johnson, N. Jones, C. Jones, C. Jordan, J. Jose´ Nu´ nez Ju, ~ M. Jose´ Pizarro, C. Jose Salazar J. Joseph, C. Justiniano, T. Kabir, M. Kadhum, C. Kalfountzos, E. Kalogiannaki, K. Kalyanasundaram, S. Kamarajah, M. Kamil Quraishi, Y. Kanemitsu, A. Kapila, V. Kapila, G. Karagiannidis, M. Kashif, S. Kathiravelupillai, A. Kathiravelupillai, E. Katsogridakis, K. Kaur, H. Kaur Sekhon Inderjit Singh, N. Kausur, M. Kawka, G. Keehan, S. Kehlet Watt, M. Kelly, M. E. Kelly, I. Kelvin Egbuchulem, G. Kembuan, E. Khajeh, A. Khaled Elfaitur, M. F. Khan, S. Khan, M. Khan, D. Khan, H. Khan, H. Khatkar, E. Khatkov, R. Khaw, B. Kim, K. Kishore Siddiraju, D. Kitua, B. Kırımtay, S. Kmezic, S. Knight, T. Koe¨ter, A. Koh, F. Koh Hong Xiang, T. Kojo Anyomih, A. I. N. Kok, R. Kokelaar, I. Koliarakis, S. Kolli, J. Kong, D. Ko¨ nig, M. otze, A. Kourdouli, M. Kowal, A. Kraima, F. Kramer, M. Kryzauskas, I. Kuchynskyi, C. Kuemmerli, S. Kuiper, S. Kumar, A. Kumar, L. Kumar, H. Kumar, N. Kumar, S. Kumar Bandyopadhyay, P. Kumar Garg, S. Kumar Venkatappa, J. Kung, S. Kural, A. Kushairi, E. Kuuzie, M. Kvietkauskas, I. Kwek, J. La, L. Lai, S. Lakpriya, K. Lam, M. Lami, I. Lansdorp-Vogelaar, P. Lapolla, H. Larsen, J. Latif, U. Laudari, A. Laurnezi, A. Lawal, S. Lawday, H. Lederhuber, A. Lednev, R. Lee, M. E. van Leerdam, G. Lefevbre, M. Lesmus, F. A. Leyva Moraga, E. Leyva Moraga, F. Leyva Moraga, H. L. Li, A. Li, Z. Li, E. Licardie, A. Light, A. L. Lightner, A. Lin, E. Lincango, F. Litta, H. Liu, B. Lofthouse, M. A. Londono, R. Lopes, R. Lopes de Freitas, L. Lopez, A. I. Lo´ pez, J. ~ Lopez-Gomez, G. Lopez-Pena, R. Lowe, D. Lowe, M. Lowey, G. Loy, V. Lozanovski, J. Luzon, P. Lynn, T. Maccabe, A. Machielsen, C. A. Mafla Herrerı´a, L. Maggino, K. Mahawar, D. Mahmood, M. Mahmoud, K. Mahtani, I. Maitra, S. Maji, I. Majiet, L. Mal, J. Malherbe, K. Malhotra, P. Malkomes, E. Man, A. Manan Sheikh, S. Manjunath, R. Manzano Nunez, S. Manzoor, R. Maqsood, G. ~ Marchegiani, F. Marchegiani, D. Marı´n, A. Marin, I. Marks, E. Marson, A. Martensen, D. Martin, G. Martı´n Martı´n, B. Martin-Perez, P. Martinez, P. Marwaha, C. Mashauri, H. Mashbari, Ł. Masior, R. Masri, L. Masud, S. Masudi, G. Mateu Calabuig, S. Math, A. Matrachisia, J. Mayol, D. Mazingi, A. Mazzotta, J. McAlinden, G. McCabe, L. McColm, H. McElvaney, K. McGivern, J. McGovern, E. McGuinness, N. McInerney, S. Mckay, C. McKee, M. McKenna, N. McKenna, K. McLean, S. Mediratta, Y. Medkova, O. Medzhidov, A. Mehraj, M. Mekhael, O. Mekinde, C. Mellenthin, A. Melucci, K. Mentor, J. Merchant, H. Messias, M. Messeha, C. Meza, P. Mhango, M. Miladinov, M. Milagros Niquen Jimenez, P. Miller, E. Mills, A. Milton, O. A. Minayeva, Z. MinHua Zheng, H. Mischlinger, B. Mo¨ ckli, R. Modi, H. M. Mohamed, M. Mohamed, T. Mohamed Abulghasm, S. A. Mohammad, T. O. Mohammed, A. Mohammed, H. Mohan, M. Mohan, I. Moin, V. Mok, G. Molina, J. Moloney, J. Moneim, M. Monfort Mira, B. Montcusı´ Ventura, M. Montouri, M. Moossdorff, I. Mora-Guzma´ n, B. Moran, R. A. R. Mora´ n, S. Moreno-Ordaz, A´ . Morera, R. Morgan, R. Morley, D. Moro-Valdezate, S. Moros, J. -L. Moss, A. Morven, D. Morton, A. Moynihan, M. Moyo´ n, N. Muduli, N. Mugla, W. Mugla, P. Mu¨ ller, G. Mun, R. Mundhada, I. Munir, F. Munoz, E. Mu ~ noz, A. Mu ~ noz, D. ~ C. Munoz Balderas, E. Murgitroyd, V. Murray, S. Murthy, W. ~ Mushiwokufa, H. Mustafa, B. Mustakimov, P. Mutambanengwe, P. Myint, S. Nadkarni, P. A. Naess, S. Nahar, P. Naidoo, R. Nam, S. Nandhra, N. Nanjappa, V. Narasimhan, W. Nardi, M. Nasir, A. Naughton, D. Naumann, S. Navarro, M. Nawaaz Karimbocus, A. Nazir, S. Ndereya, A. Ndong, I. Negoi, D. Nel, D. Nelson, S. Nepal, T. Nugent, D. Nepogodiev, J. Neufeld, J. Ng, D. Ng, C. E. Ng, S. Ngaserin, L. Ngu, E. Ngwenya, R. N. Fhearaigh, T. -K. Nikolousakis, M. Ninkovic, G. Nita, C. Nitschke, E. Noren, T. Noton, A. Novikova, Z. Nowinka, T. Nyakunengwa, A. Nyalundja, I. Nzenwa, H. Ø Kristensen, C. O’Brien, L. O’Brien, S. O’Brien, J. O’Reilly, S. O’Rourke, M. O’Sullivan, M. O’Dwyer, L. Ochieng, E. Oderoha, K. E. Oh, L. O¨ hlberger, M. O¨ lc¸u¨ m, A. Olkina, M. Omkumar, B. Omnitel, D. Oncel Yakar, K. Ong, L. Ong Wei Lin, R. Ooi, S. Ooi, A. Oomman, D. Oon Tyjet, S. Opiyo, J. J. Oscullo Yepez, N. Osei-kuffour, T. Osunronbi, A. Ottlaka´ n, S. Oussama Kacimi, S. Ovaere, A. Ozair, F. Pachler, S. Pai Oo, S. Paiella, L. Panaiotti, N. Panda, S. Pandarinath, D. Pandey, S. Pandrowala, F. Papa Mamadou, M. Paranathala, J. Park, C. Parmar, A. Parvez, L. Pasovic, A. Pasquer, N. Pasumarthy, F. Pata, T. Patel, P. Patel, N. Patel, M. Patel, N. Patron Uriburu, R. Patrone, A. Paul, O. M. Pavan Kumar, A. Pavithran, M. Pedraza Ciro, G. Pellino, A. Peloso, M. T. Pena~ Gallardo, A. Pena Velazquez, J. Perea, L. E. Pe´rez-Sa´ nchez, T. ~ Perra, G. Perrotta, P. Petersson, G. Petra, N. Petrucciani, C. Pickin, V. Pino, E. Pinotti, F. Pinto, P. Plum, F. Podesta, T. Pollini, M. Pompeu Sa´, F. Ponce Leon, H. S. Ponniah, X. Ponte de Sousa, J. Ponton, A. Pontula, M. Popa, A. L. Portilla, F. Posner, S. Post, A. Potolicchio, S. Pouwels, A. Povo, P. Prasad, S. Preciado, R. Preece, D. Proud, J. A. Pulido Segura, N. Puliyath, M. Qui, A. S. Quimbaya Rodrı´guez, W. Raby-Smith, A. Racovit¸a, A. Rad, R. Radwan, M. Rafaih Iqbal, A. Rafik, B. Raguan, M. Rahi, J. -L. Rahiri, J. Rahme, L. Rai, A. Raj, A. Raj Saksena, M. Raja, J. Ramirez, J. Ramzi, J. Ranstam, C. Rao, A. Rashid, B. Ratnayake, K. Rattanasirivilai, K. Raubenheimer, N. Ravikumar, S. Ravn, N. Razoz, W. Rea, A. Regan, M. Rela, A. Remme, C. E. Rey Chaves, A. Reyes, A. Riad, D. Rice, K. Rios Quintana, A. Ritter, M. Roalsø, D. Robinson, J. Rodriguez, F. Rodrı´guez, M. C. Rodriguez, A. Rogers, J. Rohila, D. Romanyuc, I. Romic, M. Rommaneh, G. Rompianesi, F. Rosa, F. Roscio, A. Rose, T. Rotimi, H. Ruiz, J. Ruiz Yucuma, E. Ruiz-U´ car, M. Ruslan, M. Rutega˚ rd, E. Ryan Harper, A. Ryckx, D. Rydbeck, E. Fonseca, A. Sanchez Teran, S. Sanchez Ussa, O. Sandli, H. Sanfey, J. Sanghera, I. Sani, M. Santafe Guerrero, M. Sante Fornasiero, O. Santes Jasso, I. Santos Pereira, H. Santos Sousa, A. Saratzis, A. Sarmiento Alarcon, T. Saumtally, R. 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Mcguinness, E, Mcinerney, N, Mckay, S, Mckee, C, Mckenna, M, Mckenna, N, Mclean, K, Mediratta, S, Medkova, Y, Medzhidov, O, Mehraj, A, Mekhael, M, Mekinde, O, Mellenthin, C, Melucci, A, Mentor, K, Merchant, J, Messias, H, Messeha, M, Meza, C, Mhango, P, Miladinov, M, Milagros Niquen Jimenez, M, Miller, P, Mills, E, Milton, A, Minayeva, O, MinHua Zheng, Z, Mischlinger, H, Mockli, B, Modi, R, Mohamed, H, Mohamed, M, Mohamed Abulghasm, T, Mohammad, S, Mohammed, T, Mohammed, A, Mohan, H, Mohan, M, Moin, I, Mok, V, Molina, G, Moloney, J, Moneim, J, Monfort Mira, M, Montcusi Ventura, B, Montouri, M, Moossdorff, M, Mora-Guzman, I, Moran, B, Moran, R, Moreno-Ordaz, S, Morera, A, Morgan, R, Morley, R, Moro-Valdezate, D, Moros, S, Moss, J, Morven, A, Morton, D, Moynihan, A, Moyon, M, Muduli, N, Mugla, N, Mugla, W, Muller, P, Mun, G, Mundhada, R, Munir, I, Munoz, F, Munoz, E, Munoz, A, Munoz Balderas, D, Murgitroyd, E, Murray, V, Murthy, S, Mushiwokufa, W, Mustafa, H, Mustakimov, B, Mutambanengwe, P, Myint, P, Nadkarni, S, Naess, P, Nahar, S, Naidoo, P, Nam, R, Nandhra, S, Nanjappa, N, Narasimhan, V, Nardi, W, Nasir, M, Naughton, A, Naumann, D, Navarro, S, Nawaaz Karimbocus, M, Nazir, A, Ndereya, S, Ndong, A, Negoi, I, Nel, D, Nelson, D, Nepal, S, Nugent, T, Nepogodiev, D, Neufeld, J, Ng, J, Ng, D, Ng, C, Ngaserin, S, Ngu, L, Ngwenya, E, Fhearaigh, R, Nikolousakis, T, Ninkovic, M, Nita, G, Nitschke, C, Noren, E, Noton, T, Novikova, A, Nowinka, Z, Nyakunengwa, T, Nyalundja, A, Nzenwa, I, Kristensen, H, O'Brien, C, O'Brien, L, O'Brien, S, O'Reilly, J, O'Rourke, S, O'Sullivan, M, O'Dwyer, M, Ochieng, L, Oderoha, E, Oh, K, Ohlberger, L, Olcum, M, Olkina, A, Omkumar, M, Omnitel, B, Oncel Yakar, D, Ong, K, Ong Wei Lin, L, Ooi, R, Ooi, S, Oomman, A, Oon Tyjet, D, Opiyo, S, Oscullo Yepez, J, Osei-Kuffour, N, Osunronbi, T, Ottlakan, A, Oussama Kacimi, S, Ovaere, S, Ozair, A, Pachler, F, Pai Oo, S, Paiella, S, Panaiotti, L, Panda, N, Pandarinath, S, Pandey, D, Pandrowala, S, Papa Mamadou, F, Paranathala, M, Park, J, Parmar, C, Parvez, A, Pasovic, L, Pasquer, A, Pasumarthy, N, Pata, F, Patel, T, Patel, P, Patel, N, Patel, M, Patron Uriburu, N, Patrone, R, Paul, A, Pavan Kumar, O, Pavithran, A, Pedraza Ciro, M, Pellino, G, Peloso, A, Pena Gallardo, M, Pena Velazquez, A, Perea, J, Perez-Sanchez, L, Perra, T, Perrotta, G, Petersson, P, Petra, G, Petrucciani, N, Pickin, C, Pino, V, Pinotti, E, Pinto, F, Plum, P, Podesta, F, Pollini, T, Pompeu Sa, M, Ponce Leon, F, Ponniah, H, Ponte De Sousa, X, Ponton, J, Pontula, A, Popa, M, Portilla, A, Posner, F, Post, S, Potolicchio, A, Pouwels, S, Povo, A, Prasad, P, Preciado, S, Preece, R, Proud, D, Pulido Segura, J, Puliyath, N, Qui, M, Quimbaya Rodriguez, A, Raby-Smith, W, Racovita, A, Rad, A, Radwan, R, Rafaih Iqbal, M, Rafik, A, Raguan, B, Rahi, M, Rahiri, J, Rahme, J, Rai, L, Raj, A, Raj Saksena, A, Raja, M, Ramirez, J, Ramzi, J, Ranstam, J, Rao, C, Rashid, A, Ratnayake, B, Rattanasirivilai, K, Raubenheimer, K, Ravikumar, N, Ravn, S, Razoz, N, Rea, W, Regan, A, Rela, M, Remme, A, Rey Chaves, C, Reyes, A, Riad, A, Rice, D, Rios Quintana, K, Ritter, A, Roalso, M, Robinson, D, Rodriguez, J, Rodriguez, F, Rodriguez, M, Rogers, A, Rohila, J, Romanyuc, D, Romic, I, Rommaneh, M, Rompianesi, G, Rosa, F, Roscio, F, Rose, A, Rotimi, T, Ruiz, H, Ruiz Yucuma, J, Ruiz-Ucar, E, Ruslan, M, Rutegard, M, Ryan Harper, E, Ryckx, A, Rydbeck, D, Sa-Marta, E, Sadien, I, Safari Nteranya, D, Sagoo, K, Sakata, S, Saladino, E, Saleem, A, Saleem, S, Salehi, M, Salih, S, Sallinen, V, Salvans, S, Sam, Z, Samadov, E, Sampaio Alves, M, Sanad, A, Sanchez Fonseca, S, Sanchez Teran, A, Sanchez Ussa, S, Sandli, O, Sanfey, H, Sanghera, J, Sani, I, Santafe Guerrero, M, Sante Fornasiero, M, Santes Jasso, O, Santos Pereira, I, Santos Sousa, H, Saratzis, A, Sarmiento Alarcon, A, Saumtally, T, Sayyed, R, Schettino, M, Schleimer, L, Schmidt, T, Schondffelt, K, Schwab, M, Scott, A, Searle, H, Sebopelo, L, Seeglier, B, Seishima, R, Semenvov, D, Senent-Boza, A, Sepulveda, J, Serenari, M, Serrano Navidad, M, Sert, I, Sewart, E, Sgro, A, Shadrina, V, Shah, K, Shahid, F, Shalaby, M, Shankar, B, Shapiro, J, Sharma, L, Sheel, A, Shenfine, A, Shenoy, S, Sherif, A, Shetty, N, Shetty, R, Sia, T, Sichimba, D, Siddique, H, Siddiqui, I, Simkens, G, Simoe, J, Simon, H, Sinan, L, Singh, T, Singh, K, Singh, Y, Sinha, L, Siragusa, L, Sluckin, T, Smart, Y, Smith, H, Smith, K, Smits, L, Sneep-Van Kessel, C, Sohrabi, C, Solorzano Pineda, O, Soma, A, Sooriyapiragasam, L, Soreide, K, Sparavigna, M, Spence, R, Spencer, N, Spiers, H, Spinelli, A, Sprakel, J, Sravanam, S, Srinivasan, M, Srinivasan, R, Staniszewska, A, Stanworth, S, Stasinos, K, Steele, R, Steinholt, I, Steinruecke, M, Stephen, B, Stijns, J, Still, M, Stupalkowska, W, Subba, S, Subbotin, V, Sucharitkul, P, Sudarsanam, A, Sudhamsh Reddy, D, Suhardja, T, Suliman, M, Sund, M, Sunilkumar, A, Suresh, N, Sussmes, S, Sutton, P, Syltern, J, Taha, A, Takamizawa, Y, Takoutsing Dongmo, A, Tamas, T, Tan, L, Tan, J, Tan, K, Tan, E, Tan Yong Hui, A, Tanase, A, Tariverdiev, A, Tasnem, A, Tatar, C, Tay, E, Tejedor, P, Tesfaye, G, Tetinou, F, Thorpe, C, Thyo, A, Tlelo Amastal, D, Tolani, M, Tolga Saracoglu, K, Tolgyes, T, Tong, J, Torrent Jansa, L, Toscano Igartua, S, Tovani Palone, M, Traff, H, Trevis, J, Tummers, W, Tur, A, Turchenko, I, Uche, V, Uddin, A, Udonsak, N, Ullah, M, Urbonas, T, Uwins, C, Uy Magadia, E, Uzair Qureshi, A, Uzun, K, Vadim, P, Valarche, G, Valdez Gonzalez, R, Vallee, M, Van Beek, D, Van Dalen, A, Van Den Hondel, D, Van Der Stok, E, Van Dorp, M, Van Oostendorp, S, Van Praag, E, Van Rees, J, Van Silfhout, L, Varga, Z, Varghese, S, Varghese, C, Varghese, J, Vasilica, A, Vasquez Ojeda, X, Vega, E, Vehler, S, Venchiarutti, R, Vengatesan, S, Venn, M, Verma, D, Vianey Partida Nava, G, Victoria, D, Vieira, P, Vilar Alvarez, M, Vinci, D, Viscasillas Pallas, G, Viswanath, M, Vivanco, J, Vizcaya Rodriguez, V, Vo, J, Volchanski, D, Voron, T, Voronovskyi, Y, Vu, J, Wadhwa, M, Wadhwa, S, Wagner, G, Wallace, M, Wang, Y, Wang, J, Wani, A, Wanigasooriya, K, Wanjara, S, Wanjiku, N, Warner, C, Wei Leow, T, Weiser, T, Weisters, M, Wellington, M, Wells, C, Wenzelberg, C, Wettstein, D, Wezel, A, Wheldon, L, Widmer, L, Wilson, M, Wigmore, S, Wijayaratne, T, Wijeyaratne, M, Wijnhoven, B, Wilkin, R, Williams, E, Willis, F, Winter, D, Wirsik, M, Wishah, B, Wong, G, Wong, W, Wong, K, Worku, D, Wright, E, Wright, J, Wroe Wright, O, Xenacki, S, Xia, W, Xu, W, Xu, Z, Yalcinkaya, A, Yang, W, Yang, P, Yanishev, A, Yanzon De La Torre, A, Yao, H, Yaqoob, E, Yen Ling Quake, S, Yeo, D, Yeom, B, Yershov, D, Yiasemidou, M, Yildiz, A, Yiu, A, Yoav, M, Yong, E, Yoshimura, R, Younis, M, Younis Ringshawl, Z, Youssef, M, Yue, Y, Yuen, S, Yuldashev, R, Yurttas, C, Yves, B, Zaborowski, A, Zackeri, R, Zafar, A, Zahra, W, Zaidi, A, Zainudin, S, Zakeri, R, Zamora, I, Zamora, A, Zawistowski, M, Zbikowska, G, Zegers, W, Zehra, S, Zeyra, A, Zhagniyev, Z, Zhukova, L, Zivanovic, M, Zmuc, J, Zope, M, Zubayraeva, A, Zucker, B, Aguilera-Arévalo, M -L, Aguirre Salamanca, E J, Al-Asali, N, Altıner, S, Alvarez Lozada, L A, Anastasopoulos, N -A, Andrés Urrutia, J, Angarita, K -L, Ángel FreirÍa Eiras, M, Anwar, M A, Apampa, T O, Archila Godínez, M I, Arteaga Asensio, P C, Bankole, N D A, Barreras Espinoza, J A, Bhatti, M T, Bonci, E -A, Borunda Escudero, G E, Bosco, S J, Boström, P, Botelho de Alencar Ferreira Cruz, P, Caicedo, E Y, Castañeda Ramírez, O A, Catalán, V, Chen, H W, Chowdhury, M R, Chua, H W, Coelen, R -J, Colás-Ruiz, E, Correia de Sá, T, Coşgun Acar, N, D’Alessio, R, David, S O, de Andres Crespo, M, de Berker, H, de Dieu Ngo, P, de la Caridad Espinosa Luis, R, de Lacy, B, de Montserrat Medina Sifuentes, A, del Rio, C, Demirbaş, I, Díaz, Á, Diaz del Gobbo, G, Diaz-Castrillon, C, du Plessis, M C, Dumbrava, B -D, Efrén Lozada Hernández, E, Fernández Alberti, J, Forero, M P, Fredriksson, Å, Fülöp, A, Gatan, R G, Gortázar, S, Gregório, L, Grüter, A, Gülçek, E, Hafeez Bhatti, A B, Hoh, S M, Hölmich, E, Hüttner, F, Alhasan, A J M S, Perez Rivera, C J, Jácome, F, Jariod-Ferrer, Ú, José, J, José Núñez Ju, J, José Pizarro, M, Khan, M F, Kırımtay, B, Kmezić, S, Koëter, T, König, D, Leyva Moraga, F A, Li, H L, Londoño, M A, Lopes de Freitas, R, López, A I, Mafla Herrería, C A, Manzano Nuñez, R, Marín, D, Martín Martín, G, Masior, Ł, Möckli, B, Mohamed, H M, Mohammad, S A, Mohammed, T O, Montcusí Ventura, B, Mora-Guzmán, I, Morán, R A R, Morera, Á, Moss, J -L, Moyón, M, Müller, P, Muñoz, F, Muñoz, E, Muñoz, A, Muñoz Balderas, D C, Ng, C E, Fhearaigh, R N, Nikolousakis, T -K, Kristensen, H Ø, O’Brien, L, O’Brien, S, O’Reilly, J, O’Rourke, S, O’Sullivan, M, O’Dwyer, M, Oh, K E, Öhlberger, L, Ölçüm, M, Oscullo Yepez, J J, Osei-kuffour, N, Ottlakán, A, Pavan Kumar, O M, Peña Gallardo, M T, Peña Velazquez, A, Pérez-Sánchez, L E, Pompeu Sá, M, Ponniah, H S, Ponte de Sousa, X, Portilla, A L, Pulido Segura, J A, Quimbaya Rodríguez, A S, Racoviţă, A, Rahiri, J -L, Rey Chaves, C E, Roalsø, M, Rodríguez, F, Rodriguez, M C, Ruiz-Úcar, E, Rutegård, M, Sá-Marta, E, Sam, Z H, Emile, Sameh H, Sánchez Fonseca, S, Sgrò, A, Sia, T C, Smart, Y W, Sneep-van Kessel, C, Solórzano Pineda, O, Stephen, B -J, Takoutsing Dongmo, A B, Tamás, T, Tan, J L, Thyø, A, Tölgyes, T, Torrent Jansà, L, Tovani Palone, M R, Valdez Gonzalez, R A, van Beek, D -J, van Dalen, A S, van den Hondel, D, van der stok, E, van Dorp, M, van Oostendorp, S, van Praag, E, van Rees, J, van Silfhout, L, Vasilica, A -M, Vásquez Ojeda, X, Vilar Alvarez, M E, Viscasillas Pallàs, G, Vizcaya Rodríguez, V, Wang, Y Y, Wellington, M J, Wirsik, M M, Wong, W J, Wong, K -Y, Wright, O Wroe, Yang, P -C, Yanzon de la Torre, A, Younis, M U, Zamora, A T, and Surgery
Subjects: Adult, Male, medicine.medical_specialty, Biomedical Research, Coronavirus disease 2019 (COVID-19), International Cooperation, Practice Patterns, Commission, Global Health, Health Services Accessibility, Perioperative Care, Education, Surgeon, COVID-19, surgery, perioperative care, Medical, Pandemic, Humans, Medicine, Practice Patterns, Physicians', Graduate, Pandemics, Surgeons, Health Resource, Infection Control, Physicians', Surgical Procedures, business.industry, General surgery, Middle Aged, Operative, Education, Medical, Graduate, Surgical Procedures, Operative, Perioperative care, Health Resources, Surgery, Female, business, Human
Abstract: Background Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues’ experiences and published evidence. Methods In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.
Published: 2021
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4. Corrigendum to '73 - Five years of stereotactic radiotherapy for early lung cancer: Biopsy rates, outcomes and implications' [Lung Cancer, 139, 1, (January 2020) Page S31]

Author: S. Lock, Neal Navani, A. Colori, U. Johnson, Z. Tan, Z. Jani, D. Carnell, H. Grimes, D. D’Souza, P. Bhudia, K. Quingua, C. Hiley, R. Mendes, P. Leonard, and K. McGeady
Subjects: Pulmonary and Respiratory Medicine, Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Early lung cancer, medicine.disease, Stereotactic radiotherapy, Oncology, Biopsy, medicine, Radiology, Lung cancer, business
Published: 2020
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5. EP-1658 Stereotactic Ablative Body Radiotherapy:UK implementation and current practices.Progress since

Author: G. Distefano, H. Grimes, S. Garikipati, and Matthew Hatton
Subjects: Radiation therapy, medicine.medical_specialty, Oncology, business.industry, medicine.medical_treatment, Ablative case, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Hematology, Current (fluid), business
Published: 2019
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6. EP-2067 Data driven region of interest respiratory surrogate signal extraction from CBCT data

Author: H. Grimes, A. Akintonde, Ricky A. Sharma, S. Moinuddin, Jamie R. McClelland, and K. Thielemans
Subjects: Oncology, business.industry, Computer science, Region of interest, Signal extraction, Radiology, Nuclear Medicine and imaging, Pattern recognition, Hematology, Artificial intelligence, Respiratory system, business, Data-driven
Published: 2019
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7. PO-1118 Reproducibility of lung volume with an external surrogate for respiration for deep inspiration breath hold (DIBH)

Author: L. Allington, S. Wickers, A. Cassoni, N. Hindocha, and H. Grimes
Subjects: Reproducibility, Oncology, business.industry, Radiology Nuclear Medicine and imaging, Respiration, Medicine, Radiology, Nuclear Medicine and imaging, Lung volumes, Hematology, business, Nuclear medicine, Deep inspiration breath-hold
Published: 2015
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8. DETECTION OF CRYPTOSPORIDIUM PARVUM AND GIARDIA LAMBLIA CARRIED BY SYNANTHROPIC FLIES BY COMBINED FLUORESCENT IN SITU HYBRIDIZATION AND A MONOCLONAL ANTIBODY

Author: Norman J. Pieniazek, Alexandre J. da Silva, Thaddeus K. Graczyk, Barbara H. Grimes, Duncan A. Veal, and Ronald Knight
Subjects: biology, animal diseases, fungi, Giardia, Cryptosporidium, biology.organism_classification, medicine.disease_cause, Virology, digestive system diseases, Microbiology, Apicomplexa, chemistry.chemical_compound, fluids and secretions, Infectious Diseases, Cryptosporidium parvum, chemistry, parasitic diseases, Genotype, medicine, Giardia lamblia, Protozoa, Parasitology, Fluorescein isothiocyanate
Abstract: Wild-caught synanthropic flies were tested for the presence of Cryptosporidium parvum and Giardia lamblia on their exoskeletons and in their digestive tracks by fluorescent in situ hybridization and fluorescein isothiocyanate (FITC)-conjugated monoclonal antibody (MAb) against Cryptosporidium and Giardia cell wall epitopes. The levels of C. parvum were positively correlated with the levels of G. lamblia, indicating a common source of contamination. The majority of oocysts and cysts were potentially viable (C. parvum = 80% and G. lamblia = 69%). More G. lamblia cysts occurred on the exoskeleton of the flies than within the digestive tracts; the opposite relationship was observed for C. parvum. No genotype other than C. parvum G2 was found to be associated with flies. Because filth flies carry viable C. parvum oocysts and G. lamblia cysts acquired naturally from unhygienic sources, they can be involved in the epidemiology of cryptosporidiosis and giardiasis. Fluorescent oligonucleotide probes used together with FITC-conjugated MAb represent a convenient and cost-effective technique for rapid and specific identification of human-infectious species of Cryptosporidium and Giardia mechanically transported by flies, and for the assessment of the viability of these pathogens.
Published: 2003
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9. Effects of centralized and onsite wastewater treatment on the occurrence of traditional and emerging contaminants in streams

Author: G M, Ferrell and B H, Grimes
Subjects: Pharmaceutical Preparations, Rivers, North Carolina, Organic Chemicals, Wastewater, Waste Disposal, Fluid, Water Pollutants, Chemical
Abstract: The authors conducted a survey of small streams to evaluate the effects of centralized and onsite wastewater treatment on the occurrence of selected traditional and emerging contaminants in small streams in the upper Neuse River basin, North Carolina. An undeveloped site was included to assess effects of residential land use activities on stream quality. Concentrations of nutrients and ions were higher in samples from streams in residential sites than from the stream in an undeveloped area. Overall, streams draining residential areas showed relatively small differences with respect to type of wastewater treatment. Two sites, however--one in an area of centralized wastewater treatment apparently near a suspected sewer line leak, and the second in an area of onsite wastewater treatment--showed effects of wastewater. Organic wastewater compounds were detected more frequently in samples from these two sites than from the other sites. Optical brighteners levels were correlated (r2 = .88) with the number of organic wastewater and pharmaceutical compounds detected at the residential sites and could potentially serve as a screening method to assess wastewater effects on small streams.
Published: 2014

10. EP-1664: Radiotherapy treatment verification in a cohort of limb sarcoma patients: an audit of departmental practice

Author: S. Petkar, S. Nash, F. Le Grange, H. Grimes, Beatrice Seddon, and S. Moinuddin
Subjects: medicine.medical_specialty, business.industry, General surgery, Hematology, Audit, medicine.disease, Surgery, Oncology, Radiology Nuclear Medicine and imaging, Cohort, medicine, Radiology, Nuclear Medicine and imaging, Radiotherapy treatment, Sarcoma, business
Published: 2015
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11. Water-quality characteristics indicative of wastewater in selected streams in the upper Neuse River Basin, Durham and Orange Counties, North Carolina, from 2004 to 2013

Author: Alexandria K. Graves, Matthew S. Yearout, Michael T. Meyer, Barbara H. Grimes, Gloria M. Ferrell, and Sharon A. Fitzgerald
Subjects: Hydrology, geography, geography.geographical_feature_category, Wastewater, Drainage basin, Environmental science, STREAMS, Orange (colour), Water quality
Published: 2014
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12. Simple method for comparing reliability of two serum tumour markers in breast carcinoma

Author: R Skehill, H Grimes, H F Given, D P O'Brien, and D. B. Gough
Subjects: CA15-3, Metastatic breast, medicine.medical_specialty, Pathology, ca15-3, monoclonal-antibodies, Mammary gland, mca, Breast Neoplasms, Sensitivity and Specificity, Gastroenterology, Pathology and Forensic Medicine, Antigens, Neoplasm, Internal medicine, Biomarkers, Tumor, medicine, Carcinoma, Humans, Cutoff, Antigens, Tumor-Associated, Carbohydrate, False Positive Reactions, Neoplasm Metastasis, disease, Receiver operating characteristic, Epithelioma, business.industry, carcinoembryonic antigen, General Medicine, medicine.disease, medicine.anatomical_structure, ROC Curve, Female, cancer patients, Breast carcinoma, business, Research Article
Abstract: AIMS--To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis. METHODS--One hundred and ninety six patients "presenting" with breast carcinoma had serum CA15-3 and MCA concentrations measured. RESULTS--Using these markers as indicators of stage IV disease at the recommended laboratory level, true positive rates (TPR) and false positive rates (FPR) were obtained as follows: CA15-3 TPR = 75%, FPR = 7.4%, MCA TPR = 80%, FPR = 59.1%. By increasing the CA15-3 cutoff level to 45 U/ml, a TPR and FPR of 75% and 0.6%, respectively were obtained. By increasing the MCA cutoff level to 23 U/ml, a TPR and FPR of 65% and 2.3%, respectively, were obtained. CONCLUSIONS--Using ROC curve analysis shows that CA15-3 is a superior indicator of metastatic breast disease than MCA at recommended laboratory levels, and by altering the cutoff points, the specificity and sensitivity for both these markers can be improved.
Published: 1994
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13. Irish cardiac society

Author: D. Sugrue, S. Leavey, C. Daly, Peter Crean, H. O'Kane, O'Donnell, Victor A. Umans, J. Gibson, P. W. Johnston, J. D. Laird, D. Gladstone, J. McComb, H. C. Mulholland, T. M. Higgins, M. J. Clarkson, A. Mannion, N. P. S. Campbell, R. Sheahan, R. Power, J. J. Crowey, Benno J. Rensing, R. W.F. Campbell, Barry Bresnihan, S. E. Abrams, P. C. Gillette, F. Mulcahy, J. H. Horgan, J. Adgey, A. B. Bridges, Ian D. Graham, S. W. Webb, B. G. Craig, J. D. Allen, J. McGinley, S. McKiernan, H. Bain, David P. Foley, Carol M. Wilson, P. J. Freyne, I. Temperley, P. Shah, Cormac McCarthy, R. Refsum, F. Lavin, P. de Jaegere, T. Graham, M. Keane, Margaret McLaren, A. Hennesy, G. P. Mcneill, W. Fennell, K. S. Tan, M. J. Tobin, L. Blair, J. Finn, T. Gumbrielle, T. Kinsella, P. J. Quigley, J. P. Herman, F. Chappuis, C. Wilson, J. Galvin, Mary B. Codd, D. B. O'Keeffe, J. R.L. Hamilton, S. O’Mahony, A. J. McNeil, P. Crowe, M. Ryan, B. O’Murchu, Stuart A. Lewis, F. Coakley, Barbara J. Knick, T. J. McMurray, G. Gearty, A. Forde, L. P.N. Henry, C. Cullen, Bernard J. Gersh, Hickey N, A. Simpson, R. Ferguson, F. A. Casey, G. Geary, C. Pye, D. Cochrane, M. M. Khan, E. McGovern, Hannah McGee, C. Collins, T. H. Pringle, William Wijns, K. P. Walsh, P. A. Joseph, R. ulcahy, P. J. De Feyter, J. Hurley, L. Daly, S. R. Vallely, K. Robinson, F. Fennell, M. Lonergan, D. J. Coehrane, J. Anderson, N. Rooney, J. O'Sullivan, J. Cleland, Patricia M. Kearney, B. M. McClements, R. Clarke, John P. Bourke, H. Grimes, L. O'Sullivan, Wolfgang Rutsch, C. Austin, B. Crowe, K. Daly, S. M. Donnelly, Walter R.M. Hermans, C. M. McDaid, Jill J. F. Belch, P. A. Sullivan, P. W. Serruys, C. L. Case, M. Neligan, Frank Gannon, G. Dempsey, Aaj Adgey, P. P. Kearney, D. J. McEneaney, A. J. Stewart, Jeroen Vos, N. Danchin, C. Wren, C. J. Hilton, B. McAdam, Gilbert MacKenzie, N. El Gaylani, David R. Holmes, N. McCabe, G. King, S. Duff, A. Hasan, J. H. Dark, K. M.P. Carroll, A. S. Phillips, P. C. Oslizlok, Oliver FitzGerald, K. R. Bailey, Javier Escaned, E. Shelley, B. Maurer, S. Hunter, P. Ueland, D. McEneaney, M. Diamond, Michael Walsh, and H. Emanuelsson
Subjects: Irish, business.industry, language, Medicine, General Medicine, Ancient history, business, language.human_language
Published: 1993
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14. Vitamin d insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

Author: Eamon C Mulkerrin, C. McGreevy, N ni Chadhain, E DeLappe, H Grimes, and Timothy O'Brien
Subjects: medicine.medical_specialty, Hypercalcaemia, high prevalence, d deficiency, parathyroid-hormone, fracture risk, Population, Medicine (miscellaneous), postmenopausal women, Cohort Studies, secondary hyperparathyroidism, hypovitaminosis d, Internal medicine, medicine, Vitamin D and neurology, Humans, Prospective Studies, elderly-people, education, Prospective cohort study, Aged, Aged, 80 and over, education.field_of_study, Osteomalacia, Nutrition and Dietetics, Bone Density Conservation Agents, business.industry, vitamin d, medicine.disease, Vitamin D Deficiency, Surgery, Calcium, Dietary, Hospitalization, insufficiency, Treatment Outcome, Parathyroid Hormone, controlled-trial, Cohort, Dietary Supplements, supplementation, Secondary hyperparathyroidism, Calcium, Female, bone-mineral density, business, Cohort study
Abstract: Objectives: A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. Design: A prospective cohort study. Setting: Hospital admissions followed up as a population-based study. Subjects: A total of 114 consecutive female acute medical admissions aged over 65 years from November 2003 to January 2004 were enrolled. All admissions with hypercalcaemia, metabolic bone disease (other than osteoporosis/osteomalacia) and creatinine >= 150 mu mol/l were excluded. Interventions: iPTH, calcium and 25OHD levels were measured in each patient. Of the total, 22 were already receiving calcium and vitamin D supplementation at enrolment. The remaining 92 were commenced on 800 IU of vitamin D and 1 g calcium, and levels were reassessed after supplementation for 3 months. Results: 25-Hydroxyvitamin D insufficiency, as defined by a 25OHD concentration of < 50 nmol/l, was present in 86 (75.4%) patients at initial assessment (mean 35.8 nmol/l, s.d. 23.3). Secondary hyperparathyroidism was present in only 36.7% of those with 25OHD deficiency at baseline. Of the total, 51 (44.7%) patients presented for follow-up. 25-Hydroxyvitamin D concentration increased in this group from 42.1 nmol/l (s.d. 26.6) to 59.5 nmol/l (s.d. 27.4) after supplementation, P < 0.001, but 18(35.3%) still remained deficient. There was no significant change in iPTH or calcium following supplementation. Assessment of compliance revealed 6 (11.7%) admitted to partial or non-compliance. Conclusions: Insufficiency of 25OHD was very common in this cohort. Despite calcium and vitamin D supplementation, 25OHD concentrations failed to reach normality in a significant proportion. Maintaining vitamin D and calcium intake at the level of current recommended doses may not be sufficient to ensure adequate 25OHD stores.
Published: 2006

15. Detection of Cryptosporidium parvum and Giardia lamblia carried by synanthropic flies by combined fluorescent in situ hybridization and a monoclonal antibody

Author: Thaddeus K, Graczyk, Barbara H, Grimes, Ronald, Knight, Alexandre J, Da Silva, Norman J, Pieniazek, and Duncan A, Veal
Subjects: Cryptosporidium parvum, Giardiasis, Diptera, Cryptosporidiosis, DNA, Protozoan, Insect Vectors, Dairying, Waste Management, North Carolina, Animals, Humans, Cattle, Giardia lamblia, In Situ Hybridization, Fluorescence
Abstract: Wild-caught synanthropic flies were tested for the presence of Cryptosporidium parvum and Giardia lamblia on their exoskeletons and in their digestive tracks by fluorescent in situ hybridization and fluorescein isothiocyanate (FITC)-conjugated monoclonal antibody (MAb) against Cryptosporidium and Giardia cell wall epitopes. The levels of C. parvum were positively correlated with the levels of G. lamblia, indicating a common source of contamination. The majority of oocysts and cysts were potentially viable (C. parvum = 80% and G. lamblia = 69%). More G. lamblia cysts occurred on the exoskeleton of the flies than within the digestive tracts; the opposite relationship was observed for C. parvum. No genotype other than C. parvum G2 was found to be associated with flies. Because filth flies carry viable C. parvum oocysts and G. lamblia cysts acquired naturally from unhygienic sources, they can be involved in the epidemiology of cryptosporidiosis and giardiasis. Fluorescent oligonucleotide probes used together with FITC-conjugated MAb represent a convenient and cost-effective technique for rapid and specific identification of human-infectious species of Cryptosporidium and Giardia mechanically transported by flies, and for the assessment of the viability of these pathogens.
Published: 2003

16. The prognostic value of the tumor marker CA 15-3 at initial diagnosis of patients with breast cancer

Author: H. Grimes, J McGrath, H. F. Given, and Ray McLaughlin
Subjects: 0301 basic medicine, CA15-3, Oncology, Cancer Research, medicine.medical_specialty, Clinical Biochemistry, CA 15-3, Breast Neoplasms, Disease, Sensitivity and Specificity, Disease-Free Survival, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Predictive Value of Tests, Internal medicine, medicine, Humans, Survival analysis, Tumor marker, Neoplasm Staging, business.industry, Mucin-1, Late stage, medicine.disease, Prognosis, Survival Analysis, 030104 developmental biology, 030220 oncology & carcinogenesis, Predictive value of tests, Female, business, Follow-Up Studies
Abstract: CA 15–3 has been most widely used as a serum tumor marker in follow-up and detection of breast cancer recurrence. In this study we have specifically focused upon the prognostic implications and utility of preoperative CA 15–3 levels. We have identified on our database 414 patients with breast cancer in whom serial levels of the serum tumor marker CA 15–3 had been determined at diagnosis and follow-up. We have analyzed the follow-up and clinical outcomes in these patients and from this data we have assessed the potential of CA 15–3 as a predictor of five-year overall and disease-free survival. Our results show that an initially elevated CA 15–3 level is associated with a very poor prognosis in both early and late stage disease. Elevated pre-biopsy CA 15–3 levels are associated with 14% five-year disease-free survival rates and 17% overall survival rates at five years. In contrast, normal CA 15–3 levels are associated with 47% five-year disease-free survival rates and 54% overall survival rates at five years (p
Published: 2001

17. Clinical value of cyfra 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer

Author: J J Gilmartin, J Finn, R Rutherford, H Grimes, J Bates, I O'Muircheartaigh, and M Divilly
Subjects: Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Lung Neoplasms, bronchoscopy, Tissue Polypeptide Antigen, Population, Sensitivity and Specificity, Diagnosis, Differential, Cytokeratin, Carcinoembryonic antigen, Antigen, Antigens, Neoplasm, Predictive Value of Tests, Biomarkers, Tumor, medicine, Humans, CYFRA 21-1, education, Tumor marker, lung diseases, Keratin-19, education.field_of_study, biology, business.industry, carcinoembryonic antigen, squamous-cell carcinoma, biological tumour markers, Tissue Polypeptide Specific Antigen, lung cancer, tumor-marker, Phosphopyruvate Hydratase, cyfra 21.1, biology.protein, Keratins, Peptides, business
Abstract: In this study we looked at what useful information cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 (CYFRA 21.1), carcinoembryonic antigen (CEA), neurone-specific enolase (NSE), tissue polypeptide specific antigen (TPS), and tissue polypeptide antigen (TPA) gave when measured prospectively. All patients who were suspected of having lung cancer and who underwent diagnostic bronchoscopy in this hospital between July 1994 and May 1995 were included in the study. Of 184 patients, 87 were subsequently found to have intrathoracic malignancy, 93 were found to have benign lung disease and four were lost to follow-up. CYFRA 21.1 was the most efficient marker in differentiating benign from malignant disease, with a sensitivity of 54% and a positive predictive value of 96%. Thirty seven patients who had a negative bronchoscopy subsequently turned out to have malignant disease. Either CYFRA 21.1 or CEA was elevated in 26 (70%) of such patients. Multivariate analysis showed that only CYFRA 21.1 and CEA contributed significantly to the discriminatory power of the data. We conclude that measurement of cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 and carcinoembryonic antigen at the time of bronchoscopy significantly increased the diagnostic yield in this population and was especially useful in those patients in whom tumour biopsy was not possible at bronchoscopy.
Published: 1997

18. An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma

Author: H. Grimes, Michael J. Kerin, D. Maher, H. F. Given, Deirdre M. O’Hanlon, and P. Kent
Subjects: tumors, Cancer Research, medicine.medical_specialty, Pathology, ca15-3, Mammary gland, monoclonal-antibodies, CA 15-3, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Sensitivity and Specificity, Gastroenterology, Predictive Value of Tests, Internal medicine, medicine, Carcinoma, Humans, ca 15-3, Neoplasm Invasiveness, Neoplasm Metastasis, Stage (cooking), Lymph node, Neoplasm Staging, breast neoplasia, Epithelioma, business.industry, Mucin-1, Middle Aged, medicine.disease, df3, Postmenopause, antigen levels, medicine.anatomical_structure, Premenopause, Receptors, Estrogen, Oncology, Lymphatic Metastasis, Predictive value of tests, tumor marker, Female, Breast carcinoma, business, cancer patients, Research Article
Abstract: In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml(-1) has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
Published: 1995

19. Seventeenth sir peter freyer memorial lecture and surgical symposium

Author: D. O’Gradaigh, P. J. Byrne, P. Gillen, P. Lawlor, T. N. Walsh, T. P. J. Hennessy, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, H. Li, M. T. P. Caldwell, S. Hone, S. E. A. Attwood, I. P. Kelly, T. P. Corrigan, E. Mulligan, M. J. Kerin, N. N. Williams, K. J. Cronin, M. El Sadar, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, M. Maher, D. Hehir, A. Horgan, R. Stuart, J. A. O’Donnell, M. P. Brady, J. M. O’Donoghue, J. R. Flynn, J. Doyle, M. Gallagher, K. Connolly, M. Barry, M. G Davies, M. West, E. O’Broin, J. A. Connolly, D. Long, M. F. Shine, F. Lennon, K. J. Dawson, J. R. Novell, A. K. Burroughs, K. Rolles, W. P. Joyce, J. Dolan, J. Hyland, O. Traynor, M. Bennett, O. Tighe, H. Mulcahy, D. O’Donoghue, D. Bouchier-Hayes, D. T. Croke, G. Santos, G. Khoury, M. C. Winslet, A. A. M. Lewis, E. Beausang, K. Mealy, L. Joyce, M. McNicholls, D. McErlean, M. A. Stokes, K. Barry, R. Sullivan, J. Byrne, J. Callaghan, T. O’Gorman°, H. F. Given, M. S. Dudeney, M. P. Redmond, J. M. Deasy, V. K. Young, R. G. K. Watson, G. O’Kane, K. Murphy, C. McDowell, K. Khan, S. K. Al-Ghazal, J. McCann, R. C. Stuart, M. O’Connor, J. McCabe, J. O’Byrne, D. O’Farrell, M. Walsh, J. O’Beirne, S. O’Flannagan, A. McGuinness, O. Brady, W. Quinlan, J. P. McCabe, B. Curtin, M. Stephens, J. Stack, P. McCarthy, M. Schnall, H. Pollack, T. H. Lynch, B. Waymont, J. A. Dunn, M. A. Hughes, D. M. A. Wallace, T. E. D. McDermott, R. Grainger, E. Rogers, M. Corcoran, H. Bredin, H. Grimes, D. Lanigan, C. Roobottom, P. A. Dubbins, R. G. Choa, T. Creagh, M. R. Butler, K. J. O’Flynn, R. P. MacDonagh, D. G. Thomas, K. Dawson, J. Aitken, B. Cooke, S. P. Parbhoo, P. M. Cannon, S. C. Low, A. Dixon, I. O. Ellis, C. W. Elston, R. W. Blarney, E. D. Mulligan, K. Cronin, A. Stack, J. Ennis, F. Abbaskoor, M. K. O’Donoghue, G. Fulton, W. A. Tanner, F. B. V. Keane, B. V. Joseph, F. O. Cunningham, M. Dowling, E. Conveney, J. G. Geraghty, P. Byrne, G. Clarke, J. Duffy, N. O’Higgins, D. O’Hanlon, P. G. Horgan, D. O’Brien, C. Phelan, P. Given, P. Kent, S. Sheehan, M. P. Colgan, D. Moore, G. Shanik, P. Murphy, R. Vashisht, M. Sian, P. Franks, M. K. O’Malley, Y. Gul, D. Waldron, W. P. Hederman, H. P. Singh, S. Dias, T. Aherne, D. J. Hehir, J. A. McKeever, C. A. Bannon, D. Mehigan, T. V. Keaveney, T. F. Browne, U. M. Sivananthan, M. R. Rees, S. Whittaker, G. A. Davies, R. Vashisght, E. Sharp, A. Coady, A. Sterpetti, R. M. Greenhalgh, D. P. O’Brien, D. B. Gough, M. C. Regan, I. E. Efron, S. I. Kirk, M. Hurson, H. L. Wasserkrug, A. Barbul, S. Haynes, J. Thornton, J. Sparkes, A. D. K. Hill, C. J. Kelly, J. Gallagher, L. Modyka, H. P. Redmond, J. M. Daly, O. M. Austin, R. J. Cunney, P. A. Grace, C. Curran, J. O’Donoghue, M. Abernathy, N. Sharpe, M. Lucy, E. W. D. McDermott, P. M. Mercer, N. J. O’Higgins, G. Murugasu, A. Groeschel, M. Carmody, J. Donohue, D. H. Osborne, M. McLaughlin, J. Devlin, J. P. Phillips, Y. Ellias, M. Tahir, J. McKeever, M. Tighe, V. Lynch, M. Ahmed, P. P. A. Smyth, A. M. Hetherton, P. Horgan, M. Little, D. S. Quill, C. O. Duncan, M. O’Donnell, J. A. E. Hobby, D. Little, M. Murphy, P. Burke, P. Broe, M. McKiernan, S. J. Kirk, J. Crowe, P. MacMathuna, J. Lennon, T. Corrigan, R. O’Connell, A. Browne, A. Quershi, A. Leahy, G. Courtney, P. Grace, H. Osborne, D. J. Buckley, M. Goggin, T. A. Farrell, J. Geraghty, F. K. Keeling, P. R. O’Connell, H. Naama, E. Moore, E. Barry, C. Duffy, P. Hogan, G. Nee, M. Fahy, D. P. Kenny, V. Ellias, E. Gibney, W. Joyce, E. Gaffney, J. McMahon, M. McCabe, P. Kelly, M. Leader, C. I. Timon, P. Gullane, I. Dardick, I. McCarthy, N. F. Couse, M. Morrin, and P. V. Delaney
Subjects: General Medicine
Published: 1994
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20. Research on ultra-high-temperature materials, monolithic ceramics, ceramic matrix composites, and carbon/carbon composites

Author: T. J. Miller and H. H. Grimes
Subjects: Composite Materials
Abstract: Research on three classes of materials that show potential for allowing significant increases in operating temperatures in gas turbine engines is discussed. Monolithic ceramics, ceramic matrix composites, and carbon-carbon composites are discussed. Sintering, hot pressing, and densification are discussed.
Published: 1982

21. CA15-3: a reliable indicator of metastatic bone disease in breast cancer patients

Author: D P, O'Brien, P G, Horgan, D B, Gough, R, Skehill, H, Grimes, and H F, Given
Subjects: Antigens, Neoplasm, Biomarkers, Tumor, Humans, Bone Neoplasms, Breast Neoplasms, Female, Prognosis, Neoplasm Staging, Research Article
Abstract: Carcinoma of the breast is the most common malignancy in women and is frequently associated with metastatic bone disease and its associated osteolytic morbidity and mortality. Traditional radiological methods for mass screening bony secondaries are not cost-effective. We examined the value of the tumour marker 'CA15-3' as an alternative to conventional isotope bone scintigraphy. A total of 218 patients with breast cancer was evaluated over a 4-year period. Venous CA15-3 levels were obtained at 3-monthly intervals and bone scintigraphy annually or if the patient developed locomotor symptoms or exhibited elevated CA15-3 levels. Of these patients, 33 with metastatic breast carcinoma had an elevated tumour marker level at the time of diagnosis of their metastases; bone metastases alone = 15/17 (88%), soft tissue metastases alone = 2/6 (33%), simultaneous bony and soft tissue metastases = 7/10 (70%). The preponderance of an elevated CA15-3 in metastatic bone disease, be it in isolation or in combination with non-bone metastases, yields a sensitivity, specificity and positive predictive value of 81.5%, 66% and 92%, respectively. Although 22 of the 27 patients had an elevated CA15-3 at the time of diagnosis of their bone metastases, the remaining five patients (with tumour marker levels in the normal range) showed a similar, albeit a delayed, increase (median = 3 months). Thus, all metastatic bone disease patients demonstrated elevated marker levels. We recommend CA15-3 as a simple, reliable and inexpensive screening method for detecting bone metastases in the patient with breast carcinoma.
Published: 1992

22. 0-84. Is measurement of CEA of benefit during follow up in patients with primary breast carcinoma

Author: H. Grimes, Ray McLaughlin, D.M. O'Hanlon, and H.F. Given
Subjects: Oncology, medicine.medical_specialty, Breast cancer, business.industry, Internal medicine, medicine, Surgery, In patient, General Medicine, Breast carcinoma, business, medicine.disease
Published: 1997
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23. Thermal degradation of the tensile strength of unidirectional boron/aluminum composites

Author: J. E. Maisel, H. H. Grimes, and R. A. Lad
Subjects: Materials science, Structural material, Composite number, Metals and Alloys, chemistry.chemical_element, Thermal treatment, Condensed Matter Physics, chemistry, Mechanics of Materials, Aluminium, Ultimate tensile strength, Degradation (geology), Fiber, Composite material, Boron
Abstract: The variation of ultimate tensile strength with thermal treatment of B-Al composite materials and of boron fibers chemically removed from these composites in an attempt to determine the mechanism of the resulting strength degradation was studied. Findings indicate that thermally cycling B-Al represents a more severe condition than equivalent time at temperature. Degradation of composite tensile strength from about 1.3 GN/m squared to as low as 0.34 GN/m squared was observed after 3,000 cycles to 420 C for 203 micrometers B-1100 Al composite. In general, the 1100 Al matrix composites degraded somewhat more than the 6061 matrix material studied. Measurement of fiber strengths confirmed a composite strength loss due to the degradation of fiber strength. Microscopy indicated a highly flawed fiber surface.
Published: 1977
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24. Hepatitis-associated-antigen-positive hepatitis in a tuberculosis unit

Author: M Reynolds, H Hitchcock, C F McCarthy, H. Grimes, and G R Fitzgerald
Subjects: Adult, Male, medicine.medical_specialty, Tuberculosis, Adolescent, Jaundice, Hepatitis B Antigens, Feces, Internal medicine, Epidemiology, medicine, Humans, Tuberculosis, Pulmonary, Aged, Hepatitis, Cross Infection, Transmission (medicine), business.industry, Sputum, Gastroenterology, Outbreak, Middle Aged, Hepatitis B, medicine.disease, Carrier State, Immunology, medicine.symptom, business, Hospital Units, Research Article
Abstract: An outbreak of hepatitis-associated-antigen-(HB Ag)-positive hepatitis in a hospital unit for the care of male patients with pulmonary tuberculosis is described. Sixty-four patients were studied of whom 37 were HB Ag positive. Hepatitis developed in at least 20 and was icteric in 11. The illness was mild, without fatality due to hepatitis and persistent jaundice did not occur. A carrier state developed in 15 of 24 HB Ag-positive patients followed up for more than six months and was unrelated to the presence or absence of initial hepatitis. Spread of HB Ag to domestic and medical staff occurred and following the discharge of the patients, household contacts became positive. Five, all wives of patients, developed jaundice. Faeces and sputum were HB Ag negative in seropositive cases. The origin of the outbreak remains undetected. The probability of non-parenteral transmission of HB Ag in this outbreak is discussed. Closure of the unit, isolation of HB Ag-positive cases with separate toilet and kitchen facilities, and discharge of patients when their respiratory condition allowed, resulted in prevention of further spread and eventually all patients were discharged from the unit.
Published: 1975
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25. Research and the practitioner at the regional education service agency

Author: George H. Grimes and Albert L. Goldberg
Subjects: Knowledge management, business.industry, Communication, media_common.quotation_subject, Information Dissemination, Educational technology, Context (language use), Public relations, Filter (software), Education, Educational leadership, Perception, Agency (sociology), Position (finance), Business, media_common
Abstract: Practitioners in a regional education service agency have a singular and unique view of reality. Perceptions of theory, research, and development need to be seen in the context, the setting of the agency, the kind of staff it attracts, the nature of the relationship between the staff and the local school district, and how the staff performs through its own initiative and/or responds to expressions of need by local school leadership. Simply stated, the regional service agency is a user rather than a developer of new knowledge, for it tends to be more concerned with troublesome and persistent problems at the local level. Acting as consultant/broker/disseminator, the staff of the agency is mindful of the principles of local problem ownership and local involvement in planning for problem identification and uncovering alternative solutions. In performing its role, the regional agency acts as collector, filter, synthesizer, and analyzer of an inordinate amount of extant research ranging broadly in topical areas and incorporating fundamental research as well as theory and applications of products and processes. The greater the extent to which such information can be transferred expeditiously through inhouse mechanisms, the better able the staff member of the regional agency is to facilitate improvement at the local level. At the same time, the staff member is in a good position to
Published: 1978
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26. Vacancy formation in gold under high pressure

Author: Hubert H. Grimes
Subjects: Materials science, Condensed matter physics, Electrical resistance and conductance, High pressure, Vacancy defect, Hydrostatic pressure, Electric wire, General Materials Science, General Chemistry, Crystal structure, Condensed Matter Physics, Crystallographic defect
Abstract: Crystal structure defect concentration from measurement of excess electric resistance in gold wires subjected to high hydrostatic pressure
Published: 1965
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27. Spontaneous Cracking in Unfired Magnesia Compacts Upon Standing in Air

Author: Charles E. May, Hubert H. Grimes, and Myron O. Davies
Subjects: Materials science, Magnesium, Metallurgy, chemistry.chemical_element, chemistry.chemical_compound, Cracking, Adsorption, chemistry, Residual stress, Carbon dioxide, Materials Chemistry, Ceramics and Composites, Carbonate, Crystallite, Composite material, Water vapor
Abstract: Analytical-grade magnesium oxide powder without binder was compressed hydrostatically to 50,000 lb. per sq. in. to form compacts. When exposed to moist air immediately after pressing, these compacts developed irregularly shaped cracks. Controlled tests, in which these compacts were exposed for various lengths of time to various atmospheres, indicated that in general water vapor, carbon dioxide, and residual stresses had to be present if cracking was to occur. The probable cause of the cracking was the formation of a less dense and mechanically weak basic carbonate of magnesium at crystallite surface points of high stress concentration which developed during the compacting. The adsorption of dry CO2 at such sites prevented subsequent delayed fracture.
Published: 1961
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28. Contents Vol. 40, 1977

Author: Leo A. Bullara, Donald R. McNeal, Bonita Weis, Manuel Riklan, J.A. Picaza, Tim A. Fischell, Thomas Swiontek, Oscar Papazian, Blaine S. Nashold, Donald M. Dooley, I. Amin, Harry Friedman, Joseph F. Cusick, Marc A. Flitter, Sanford J. Larson, B.W. Cannon, Richard B. North, Ross Davis, William F. Agnew, Roger Avery, John H. Grimes, Robert H. Pudenz, Robert Waters, Crompton Smith, Robert F. Cullen, David C. Hemmy, Anthony Sances, Edward A. Millar, Joel B. Myklebust, C. Hunter Shelden, Danilo Duenas, Steven M. Watkins, Adrian R.M. Upton, Donlin M. Long, Irving S. Cooper, S.E. Hunter, Charles V. Burton, James Semans, James Reswick, Skip Jacques, José M. R. Delgado, Ronald Jodat, James J. Ackmann, Ted G. H. Yuen, Howard Engle, John E. Adams, L. McLellan, Jerrold Sharkey, and Patrick R. Walsh
Subjects: Cognitive science, Philosophy, Surgery, Neurology (clinical), Neuroscience
Published: 1977
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29. The Fœtus at Risk

Author: D. H. Grimes and W. J. Hamilton
Subjects: Fetus, Pregnancy, medicine.anatomical_structure, Placenta, medicine, Physiology, Organ Size, Anatomy, Anthropometry, Biology, medicine.disease, Body weight
Published: 1970
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30. Kinetics of Golgi apparatus membrane flux following monensin treatment of embryogenic carrot cells

Author: D J, Morré, W F, Boss, H, Grimes, and H H, Mollenhauer
Subjects: Microscopy, Electron, Vacuoles, Golgi Apparatus, Monensin, Plants, Furans
Abstract: Ultrastructural changes resulting from treatment with the sodium selective ionophore, monensin, were studied in embryogenic suspension cultures of carrot, Daucus carota (L.) in the presence of 10 microM monensin, an early change in the Golgi apparatus was an increase in the number of cisternae per stack (dictyosome). An average of one additional cisterna per stack was formed within the first 2 to 4 min of monensin treatment; in some experiments a second cisterna was formed within about 8 min. Thereafter, large vacuoles began to appear in the cytoplasm adjacent to the Golgi apparatus with a return of the number of cisternae per dictyosomal stack to the control number of about 5. Cells treated comparable but in the absence of monensin showed no ultrastructural changes during the entire observation period. By 1 h of monensin treatment, the regions of the cells containing dictyosomes were populated by large number of vacuoles (up to 20 or more per electron microscope section). These vacuoles were interpreted as swollen dictyosome cisternae that separated from the stack but had not migrated from the Golgi apparatus zone in the monensin-treated cells. The results permitted an estimation of the average time for formation of a new dictyosome cisterna of 2 to 4 min. This range of values agreed with estimates for mammalian cells from short time labeling and turnover experiments of 3 to 4 min assuming a dynamic model for Golgi apparatus function in which cisternae are released from a maturing face and new cisternae are built up at an opposite or forming face.
Published: 1983

31. Spurious increase in plasma potassium concentration and reduction in plasma calcium due to in vitro contamination with liquid potassium edetic acid at phlebotomy

Author: H Grimes, E L Egan, J Newell, and M F Fitzpatrick
Subjects: Blood Specimen Collection, Chromatography, Potassium, chemistry.chemical_element, Mineralogy, General Medicine, Phlebotomy, Contamination, Calcium, In vitro, Pathology and Forensic Medicine, chemistry, Serum potassium, Equipment Contamination, Humans, Edetic Acid, Research Article
Published: 1987

32. CA15-3: its relationship to clinical stage and progression to metastatic disease in breast cancer

Author: Michael J. Kerin, H. Grimes, V. P. O’Malley, Oliver J. McAnena, and H. F. Given
Subjects: CA15-3, Adult, medicine.medical_specialty, Pathology, medicine.drug_class, Mammary gland, Bone Neoplasms, Breast Neoplasms, Disease, Stage ii, Monoclonal antibody, Gastroenterology, Breast cancer, Internal medicine, Medicine, Humans, Antigens, Tumor-Associated, Carbohydrate, Stage (cooking), Neoplasm Metastasis, Aged, Neoplasm Staging, Aged, 80 and over, business.industry, Middle Aged, medicine.disease, Occult, medicine.anatomical_structure, Surgery, Female, Neoplasm Recurrence, Local, business
Abstract: There is increasing interest in the potential role of monoclonal antibodies as tumour markers in the early detection of metastatic disease. CA15-3 is a circulating antigen which is relatively specific for breast tissue and defined by two monoclonal antibodies. It is elevated in the serum of patients with breast cancer but its relationship to clinical stage and tumour progression has not been well defined. CA15-3 levels have been measured in a consecutive series of 97 patients with breast cancer at the time of diagnosis and at 3-monthly intervals thereafter. All patients have been evaluated and followed by using routine biochemical and radiological parameters to detect occult metastatic disease. There was no difference between a control group of patients who presented with benign disease (n = 18: mean(s.d.) 18·0(5·1) units/ml): and those who presented with stage I disease (n = 37: 18·4(5·3) units/ml) or stage II disease (n = 21: 18·0(4·0) units/ml). Patients with stage III disease (n = 23: 32·0(10·4) units/ml) had significantly elevated levels of CA15-3 compared with those in stage I (P
Published: 1989

33. Proceedings: Hepatitis-associated-antigen-positive hepatitis in a tuberculosis unit

Author: G R, Fitzgerald, H, Grimes, M, Reynolds, and C F, McCarthy
Subjects: Hepatitis B Antigens, Male, Humans, Tuberculosis, Hospitals, Special, Hepatitis
Published: 1973

34. Growth relationship between the foetus and the placenta

Author: W J, Hamilton and D H, Grimes
Subjects: Embryonic and Fetal Development, Fetus, Anthropometry, Pregnancy, Placenta, Body Weight, Statistics as Topic, Humans, Female, Organ Size, Placentation, Research Article
Published: 1970

35. Subject Index Vol. 40, 1997

Author: Sanford J. Larson, Charles V. Burton, Oscar Papazian, Skip Jacques, William F. Agnew, Robert H. Pudenz, Leo A. Bullara, Bonita Weis, I. Amin, Ted G. H. Yuen, Howard Engle, Manuel Riklan, Roger Avery, Harry Friedman, Crompton Smith, James Reswick, John E. Adams, B.W. Cannon, José M. R. Delgado, Donald R. McNeal, C. Hunter Shelden, Marc A. Flitter, Richard B. North, Joseph F. Cusick, David C. Hemmy, Adrian R.M. Upton, J.A. Picaza, Anthony Sances, Ronald Jodat, Steven M. Watkins, Ross Davis, Jerrold Sharkey, Joel B. Myklebust, Blaine S. Nashold, L. McLellan, Irving S. Cooper, S.E. Hunter, Danilo Duenas, James J. Ackmann, Patrick R. Walsh, Robert L. Waters, Donald M. Dooley, James Semans, Robert F. Cullen, Tim A. Fischell, John H. Grimes, Edward A. Millar, Thomas Swiontek, and Donlin M. Long
Subjects: medicine.medical_specialty, Index (economics), business.industry, Medicine, Surgery, Subject (documents), Medical physics, Neurology (clinical), business
Published: 1977
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36. Stock Market Logic: A Sophisticated Approach to Profits on Wall Street

Author: D. H. Grimes and N. G. Fosback
Published: 1977
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37. The relationship between plasma and tissue vitamin E concentrations in man

Author: P J Leonard and H Grimes
Subjects: History, medicine.medical_specialty, Chemistry, business.industry, Muscles, Myocardium, Vitamin E, medicine.medical_treatment, Computer Science Applications, Education, Endocrinology, Text mining, Liver, Internal medicine, medicine, Humans, business, Research Article
Published: 1969
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38. Prevention of Uptake of Strontium Ions on Glass

Author: G. Boocock, S. P. Wilford, and J. H. Grimes
Subjects: Strontium, Multidisciplinary, Strontium ions, Metal ions in aqueous solution, Inorganic chemistry, chemistry.chemical_element, engineering.material, Polyester, Adsorption, chemistry, Coating, engineering, Organic chemistry, Neutral ph
Abstract: THE uptake of metal ions by the walls of glass vessels is a frequently encountered phenomenon in analytical chemistry and radiochemistry, and is responsible for the difficulty of maintaining dilute solutions at a known concentration during storage. In general this problem is overcome by making such solutions acid, and neutralizing immediately before use. This technique is not applicable, however, when it is necessary to use the same solution at neutral pH for long periods of time.
Published: 1962
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39. PO-1093 Comparison of IV contrast enhancement between 4DCT and helical radiotherapy planning scans for lung cancer

Author: J. Godbold, L. Allington, H. Grimes, N. Hindocha, J. Keeble, R. Mendes, and T. Patel
Subjects: Pathology, medicine.medical_specialty, Contrast enhancement, business.industry, medicine.medical_treatment, Hematology, medicine.disease, Radiation therapy, Oncology, Radiology Nuclear Medicine and imaging, Medicine, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business, Lung cancer
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40. Preventing postnatal depression in new mothers using telephone peer support: protocol for the DAISY (Depression and AnxIety peer Support studY) multi-centre randomised controlled trial.

Author: Shafiei T, McLachlan HL, Dennis CL, Nicholson JM, Nguyen T, Shiell A, Nguyen CD, Grimes H, Bee J, Adams C, Callander E, and Forster DA
Subjects: Adult, Female, Humans, Anxiety prevention & control, Australia, Multicenter Studies as Topic, Quality of Life, Randomized Controlled Trials as Topic, Single-Blind Method, Depression, Postpartum prevention & control, Mothers psychology, Peer Group, Social Support, Telephone
Abstract: Introduction: Postnatal depression affects up to one in six new mothers in Australia each year, with significant impacts on the woman and her family. Prevention strategies can be complicated by a woman's reluctance to seek professional help. Peer support is a promising but inadequately tested early intervention. Very few trials have reported on the efficacy of peer support in the perinatal period and no study has been undertaken in Australia. We will explore if proactive telephone-based peer (mother-to-mother) support, provided to women identified as being at high risk of postnatal depression, impacts on clinically significant depressive symptomatology at 6 months postpartum., Methods and Analysis: This is a protocol for a single-blinded, multi-centre, randomised controlled trial conducted in Melbourne, Australia. Eligible women will be recruited from either the postnatal units of two maternity hospitals, or around 4 weeks postpartum at maternal and child health centres within two metropolitan council areas. A total of 1060 (530/group) women will be recruited and randomly allocated (1:1 ratio) to either-usual care, to receive the standard community postpartum services available to them, or the intervention group, to receive proactive telephone-based support from a peer volunteer for 6 months, in addition to standard community services., Primary Outcome: clinically significant depressive symptomatology at 6 months postpartum as measured using the Edinburgh Postnatal Depression Scale., Secondary Outcomes: symptoms of anxiety and/or stress, health-related quality of life, loneliness, perception of partner support, self-rated parenting, child health and development, infant feeding and health service use. The cost-effectiveness of the intervention relative to standard care will also be assessed., Ethics and Dissemination: Ethics approval has been obtained from La Trobe University, St. Vincent's Hospital, the Royal Women's Hospital, Northern Health, Victorian Department of Health and Human Services and Victorian Department of Education and Training. Written informed consent will be obtained from all participants before randomisation. Trial results will be disseminated through peer-reviewed publications, conference presentations and a higher degree thesis., Trial Registration Number: ACTRN12619000684123; Australian New Zealand Clinical Trials Registry., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2024
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41. Is proactive telephone-based breastfeeding peer support a cost-effective intervention? A within-trial cost-effectiveness analysis of the 'Ringing Up about Breastfeeding earlY' (RUBY) randomised controlled trial.

Author: McLardie-Hore FE, Forster DA, McLachlan HL, Shafiei T, Amir LH, Davey MA, Grimes H, and Gold L
Subjects: Infant, Female, Pregnancy, Humans, Cost-Benefit Analysis, Telephone, Victoria, Breast Feeding, Cost-Effectiveness Analysis
Abstract: Objective: The 'Ringing Up about Breastfeeding earlY' (RUBY) randomised controlled trial showed increased breastfeeding at 6 months in participants who received the proactive telephone-based peer support breastfeeding intervention compared with participants allocated to receive standard care and supports. The present study aimed to evaluate if the intervention was cost-effective., Design: A within-trial cost-effectiveness analysis., Setting: Three metropolitan maternity services in Melbourne, Victoria, Australia., Participants: First time mothers intending to breastfeed their infant (1152) and peer volunteers (246)., Intervention: The intervention comprised proactive telephone-based support from a peer volunteer from early postpartum up to 6 months. Participants were allocated to usual care (n=578) or the intervention (n=574)., Main Outcome Measures: Costs during a 6-month follow-up period including individual healthcare, breastfeeding support and intervention costs in all participants, and an incremental cost-effectiveness ratio., Results: Costs per mother supported were valued at $263.75 (or $90.33 excluding costs of donated volunteer time). There was no difference between the two arms in costs for infant and mothers in healthcare and breastfeeding support costs. These figures result in an incremental cost-effectiveness ratio of $4146 ($1393 if volunteer time excluded) per additional mother breast feeding at 6 months., Conclusion: Considering the significant improvement in breastfeeding outcomes, this intervention is potentially cost-effective. These findings, along with the high value placed on the intervention by women and peer volunteers provides robust evidence to upscale the implementation of this intervention., Trial Registration Number: ACTRN12612001024831., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2023
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42. Seventh BHD international symposium: recent scientific and clinical advancement.

Author: Woodford MR, Andreou A, Baba M, van de Beek I, Di Malta C, Glykofridis I, Grimes H, Henske EP, Iliopoulos O, Kurihara M, Lazor R, Linehan WM, Matsumoto K, Marciniak SJ, Namba Y, Pause A, Rajan N, Ray A, Schmidt LS, Shi W, Steinlein OK, Thierauf J, Zoncu R, Webb A, and Mollapour M
Subjects: Humans, Birt-Hogg-Dube Syndrome genetics
Abstract: The 7th Birt-Hogg-Dubé (BHD) International Symposium convened virtually in October 2021. The meeting attracted more than 200 participants internationally and highlighted recent findings in a variety of areas, including genetic insight and molecular understanding of BHD syndrome, structure and function of the tumor suppressor Folliculin (FLCN), therapeutic and clinical advances as well as patients' experiences living with this malady., Competing Interests: CONFLICTS OF INTEREST Authors have no conflicts of interest to declare., (Copyright: © 2022 Woodford et al.)
Published: 2022
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43. Current status of stereotactic ablative body radiotherapy in the UK: six years of progress.

Author: Distefano G, Garikipati S, Grimes H, and Hatton M
Abstract: Objective: To update the 2012 UK stereotacticablative radiotherapy (SABR) Consortium survey and assess the development of SABR services across the UK over the past 6 years. Use the results to share practice and continue to drive forward technique development, aid standardization and by highlighting issues, improve access to SABR services and trials across the UK., Methods: In January 2018, an online questionnaire was sent by the UK SABR Consortium to 65 UK radiotherapy institutions covering current service provision and collecting data on immobilization, motion management, scanning protocols, target/OAR delineation, planning, image-guidance, quality assurance and future plans., Results: 50 (77%) institutions responded, 38 ( vs 15 in 2012) indicated they had an active SABR programme with the remaining 12 centres intending to develop a SABR programmeDocumented changes include the development of Linac delivered SABR to non-lung sites, an increase in centres using abdominal compression (14 vs 2) and the introduction of four-dimensional cone beam CBCT. Current practice is broadly in line with UK SABR Consortium and European guidelines., Conclusion: This 2018 survey shows a welcome increase in SABR provision, surpassing 2012 projections. However, it is clear that the UK SABR program needs to continue to expand to ensure that patients with oligometastatic disease have access and SABR for early stage lung cancer is available in all centres. Updated guidance that addresses variability in target delineation, image guidance and reduces patient specific quality assurance is warranted., Advances in Knowledge: Documented progress of UK SABR across all treatment sites over the last six years, barriers to implementation and future plans., (© 2019 The Authors. Published by the British Institute of Radiology.)
Published: 2019
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44. Exploring the effect of the 'Growing Together' parenting education kit on early parenting - study protocol for a cluster randomised controlled trial.

Author: Shafiei T, McLachlan HL, Nicholson JM, Hay S, Newton M, Grimes H, McLardie-Hore F, and Forster DA
Subjects: Adult, Australia, Clinical Protocols, Female, Humans, Infant, Infant, Newborn, Male, Outcome Assessment, Health Care, Pregnancy, Surveys and Questionnaires, Education, Nonprofessional, Mothers psychology, Parenting
Abstract: Background: Significant gaps exist in education for prospective and new parents, especially for some of the most vulnerable families. Prospective parents would like more information during pregnancy to prepare them for parenting, and need access to trusted and quality information. The Royal Women's Hospital (the Women's) in Melbourne, Australia, a large tertiary referral maternity hospital, developed a parenting education kit known as 'Growing Together'. The kit, designed to guide prospective and new parents from conception until 1 year after birth, includes three components: an A4 sized book, a specifically designed 'App' and a children's story book. We aim to evaluate the impact of the kit on a range of outcomes., Methods: A two-arm cluster randomised controlled trial will be used. Antenatal clinic days will be randomised to either the intervention or standard care arms. Women in the intervention arm receive the kit at their antenatal booking visit. Women in the standard care arm receive the standard information resources at the Women's. Analyses will be by intention to treat., Inclusion Criteria: primiparous women with adequate English-speaking ability and ≤ 30 weeks' gestation at first pregnancy booking appointment. The primary outcome of the study is the 'experience of motherhood questionnaire' (EMQ), a 20 item validated self-report measure, ranging from 0 to 80, with lower scores indicating better maternal health and wellbeing. To detect a 10% difference in new mothers scoring ≤40 between women who have received the kit (60%) and those who have not (50%), would require 408 per group (total of 816 women) with 95% confidence and 80% power. Allowing for loss to follow up, we aim to recruit 1000 mothers. Secondary outcomes include parents' views and experiences of their care and of the kit during pregnancy and after the birth, parental attachment, knowledge, confidence, wellbeing and health-seeking behaviour; and emotional, developmental and physical health of the infant. Survey data will be collected from mothers at 2, 6 and 12 months postpartum and partners at 6 months., Discussion: This study will provide much needed high-level evidence on the impact of a comprehensive education resource for new parents., Trial Registration: ANZCTRN12615000270516 - Retrospectively registered (23/03/2015); trial started on 16 March 2015.
Published: 2019
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45. Pyopericardium secondary to achalasia-associated squamous cell carcinoma of the oesophagus.

Author: Mason JD, Dixon F, Grimes H, and Jones GE
Subjects: Adrenal Gland Neoplasms diagnosis, Adrenal Gland Neoplasms secondary, Candidiasis diagnosis, Carcinoma, Squamous Cell diagnosis, Endoscopy, Digestive System, Esophageal Neoplasms diagnosis, Esophageal Squamous Cell Carcinoma, Esophagoscopy, Gram-Negative Bacterial Infections diagnosis, Humans, Lactobacillus, Male, Middle Aged, Tomography, X-Ray Computed, Carcinoma, Squamous Cell complications, Esophageal Achalasia etiology, Esophageal Neoplasms complications, Pericardial Effusion etiology
Abstract: Patients with achalasia of the oesophagus are known to be at increased risk of oesophageal squamous cell carcinoma. To our knowledge, this is the first report of an achalasia-associated oesophageal squamous cell carcinoma presenting with acute sepsis secondary to pyopericardium.
Published: 2017
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46. Lipids and essential fatty acids in patients presenting with self-harm.

Author: Garland MR, Hallahan B, McNamara M, Carney PA, Grimes H, Hibbeln JR, Harkin A, and Conroy RM
Subjects: Adolescent, Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Risk Factors, Self-Injurious Behavior blood, Self-Injurious Behavior drug therapy, Cholesterol blood, Fatty Acids, Essential blood, Self-Injurious Behavior etiology, Selective Serotonin Reuptake Inhibitors therapeutic use
Abstract: Background: Low cholesterol has been reliably demonstrated in people who self-harm., Aims: To determine whether people who self-harm also have low levels of essential fatty acids (EFAs) and to examine associations between the EFAs and serotonergic function., Method: Depression, impulsivity and suicidal intent were measured in patients with self-harm (n=40) and matched controls, together with plasma lipids and EFAs. Platelet serotonergic studies were carried out in a subgroup (n=27)., Results: Patients with self-harm had significantly more pathology on all psychometric measures, lower mean total cholesterol levels (4.18 (s.d.=0.93) v. 4.87 (s.d.=0.83) mmol/l, P=0.003) and lower mean total EFA levels (89. 5 (15.6) v.103.7 (17.1) microg/ml, P=0.0001) than controls after adjustment for confounding variables. Total n-3 and n-6 EFA levels were also significantly lower. Impulsivity and depression scores were significantly inversely correlated with both n-6 EFAs and n-3 EFAs, but were not associated with total or low-density lipoprotein cholesterol levels. Platelet serotonergic measures did not differ between groups, and were not related to psychobiological measures., Conclusions: Lower plasma EFA levels combined with low cholesterol concentrations were associated with self-harm as well as impulsivity and affect. This was not related to platelet serotonergic measures.
Published: 2007
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47. Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation.

Author: DeLappe E, McGreevy C, ni Chadhain N, Grimes H, O'Brien T, and Mulkerrin E
Subjects: Aged, Aged, 80 and over, Calcium blood, Cohort Studies, Dietary Supplements, Female, Hospitalization, Humans, Parathyroid Hormone blood, Prospective Studies, Treatment Outcome, Vitamin D blood, Vitamin D Deficiency blood, Vitamin D Deficiency diagnosis, Bone Density Conservation Agents therapeutic use, Calcium, Dietary therapeutic use, Vitamin D analogs & derivatives, Vitamin D therapeutic use, Vitamin D Deficiency drug therapy
Abstract: Objectives: A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation., Design: A prospective cohort study., Setting: Hospital admissions followed up as a population-based study., Subjects: A total of 114 consecutive female acute medical admissions aged over 65 years from November 2003 to January 2004 were enrolled. All admissions with hypercalcaemia, metabolic bone disease (other than osteoporosis/osteomalacia) and creatinine > 150 micromol/l were excluded., Interventions: iPTH, calcium and 25OHD levels were measured in each patient. Of the total, 22 were already receiving calcium and vitamin D supplementation at enrolment. The remaining 92 were commenced on 800 IU of vitamin D and 1 g calcium, and levels were reassessed after supplementation for 3 months., Results: 25-Hydroxyvitamin D insufficiency, as defined by a 25OHD concentration of < 50 nmol/l, was present in 86 (75.4%) patients at initial assessment (mean 35.8 nmol/l, s.d. 23.3). Secondary hyperparathyroidism was present in only 36.7% of those with 25OHD deficiency at baseline. Of the total, 51 (44.7%) patients presented for follow-up. 25-Hydroxyvitamin D concentration increased in this group from 42.1 nmol/l (s.d. 26.6) to 59.5 nmol/l (s.d. 27.4) after supplementation, P < 0.001, but 18(35.3%) still remained deficient. There was no significant change in iPTH or calcium following supplementation. Assessment of compliance revealed 6 (11.7%) admitted to partial or non-compliance., Conclusions: Insufficiency of 25OHD was very common in this cohort. Despite calcium and vitamin D supplementation, 25OHD concentrations failed to reach normality in a significant proportion. Maintaining vitamin D and calcium intake at the level of current recommended doses may not be sufficient to ensure adequate 25OHD stores.
Published: 2006
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48. Clinical value of CYFRA 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer.

Author: Bates J, Rutherford R, Divilly M, Finn J, Grimes H, O'Muircheartaigh I, and Gilmartin JJ
Subjects: Antigens, Neoplasm blood, Carcinoembryonic Antigen blood, Diagnosis, Differential, Humans, Keratin-19, Keratins, Lung Diseases blood, Lung Diseases diagnosis, Lung Diseases epidemiology, Lung Neoplasms blood, Lung Neoplasms epidemiology, Peptides blood, Phosphopyruvate Hydratase blood, Predictive Value of Tests, Sensitivity and Specificity, Tissue Polypeptide Antigen blood, Biomarkers, Tumor blood, Lung Neoplasms diagnosis
Abstract: In this study we looked at what useful information cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 (CYFRA 21.1), carcinoembryonic antigen (CEA), neurone-specific enolase (NSE), tissue polypeptide specific antigen (TPS), and tissue polypeptide antigen (TPA) gave when measured prospectively. All patients who were suspected of having lung cancer and who underwent diagnostic bronchoscopy in this hospital between July 1994 and May 1995 were included in the study. Of 184 patients, 87 were subsequently found to have intrathoracic malignancy, 93 were found to have benign lung disease and four were lost to follow-up. CYFRA 21.1 was the most efficient marker in differentiating benign from malignant disease, with a sensitivity of 54% and a positive predictive value of 96%. Thirty seven patients who had a negative bronchoscopy subsequently turned out to have malignant disease. Either CYFRA 21.1 or CEA was elevated in 26 (70%) of such patients. Multivariate analysis showed that only CYFRA 21.1 and CEA contributed significantly to the discriminatory power of the data. We conclude that measurement of cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 and carcinoembryonic antigen at the time of bronchoscopy significantly increased the diagnostic yield in this population and was especially useful in those patients in whom tumour biopsy was not possible at bronchoscopy.
Published: 1997
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49. An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.

Author: O'Hanlon DM, Kerin MJ, Kent P, Maher D, Grimes H, and Given HF
Subjects: Breast Neoplasms pathology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Staging, Postmenopause, Predictive Value of Tests, Premenopause, Receptors, Estrogen analysis, Sensitivity and Specificity, Breast Neoplasms blood, Breast Neoplasms surgery, Mucin-1 blood
Abstract: In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
Published: 1995
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50. CA15-3: a reliable indicator of metastatic bone disease in breast cancer patients.

Author: O'Brien DP, Horgan PG, Gough DB, Skehill R, Grimes H, and Given HF
Subjects: Breast Neoplasms pathology, Female, Humans, Neoplasm Staging, Prognosis, Antigens, Neoplasm blood, Biomarkers, Tumor blood, Bone Neoplasms blood, Bone Neoplasms secondary, Breast Neoplasms blood
Abstract: Carcinoma of the breast is the most common malignancy in women and is frequently associated with metastatic bone disease and its associated osteolytic morbidity and mortality. Traditional radiological methods for mass screening bony secondaries are not cost-effective. We examined the value of the tumour marker 'CA15-3' as an alternative to conventional isotope bone scintigraphy. A total of 218 patients with breast cancer was evaluated over a 4-year period. Venous CA15-3 levels were obtained at 3-monthly intervals and bone scintigraphy annually or if the patient developed locomotor symptoms or exhibited elevated CA15-3 levels. Of these patients, 33 with metastatic breast carcinoma had an elevated tumour marker level at the time of diagnosis of their metastases; bone metastases alone = 15/17 (88%), soft tissue metastases alone = 2/6 (33%), simultaneous bony and soft tissue metastases = 7/10 (70%). The preponderance of an elevated CA15-3 in metastatic bone disease, be it in isolation or in combination with non-bone metastases, yields a sensitivity, specificity and positive predictive value of 81.5%, 66% and 92%, respectively. Although 22 of the 27 patients had an elevated CA15-3 at the time of diagnosis of their bone metastases, the remaining five patients (with tumour marker levels in the normal range) showed a similar, albeit a delayed, increase (median = 3 months). Thus, all metastatic bone disease patients demonstrated elevated marker levels. We recommend CA15-3 as a simple, reliable and inexpensive screening method for detecting bone metastases in the patient with breast carcinoma.
Published: 1992

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