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7. Poster Session 1: Sunday 3 May 2015, 08:30-18:00 * Room: Poster Area

Author

Taniguchi, Y., primary, Takahashi, Y., additional, Toba, T., additional, Yamada, S., additional, Yokoi, K., additional, Kobayashi, S., additional, Okajima, S., additional, Shimane, A., additional, Kawai, H., additional, Yasaka, Y., additional, Smanio, P., additional, Oliveira, M. A., additional, Machado, L., additional, Cestari, P., additional, Medeiros, E., additional, Fukuzawa, S., additional, Okino, S., additional, Ikeda, A., additional, Maekawa, J., additional, Ichikawa, S., additional, Kuroiwa, N., additional, Yamanaka, K., additional, Igarashi, A., additional, Inagaki, M., additional, Patel, K., additional, Mahan, M., additional, Ananthasubramaniam, K., additional, Mouden, M., additional, Yokota, S., additional, Ottervanger, J., additional, Knollema, S., additional, Timmer, J., additional, Jager, P., additional, Padron, K., additional, Peix, A., additional, Cabrera, L., additional, Pena Bofill, V., additional, Valera, D., additional, Rodriguez Nande, L., additional, Carrillo Hernandez, R., additional, Mena Esnard, E., additional, Fernandez Columbie, Y., additional, Bertella, E., additional, Baggiano, A., additional, Mushtaq, S., additional, Segurini, C., additional, Loguercio, M., additional, Conte, E., additional, Beltrama, V., additional, Petulla', M., additional, Andreini, D., additional, Pontone, G., additional, Guzic Salobir, B., additional, Dolenc Novak, M., additional, Jug, B., additional, Kacjan, B., additional, Novak, Z., additional, Vrtovec, M., additional, Volpato, V., additional, Formenti, A., additional, Pepi, M., additional, Ajanovic, R., additional, Husic-Selimovic, A., additional, Zujovic-Ajanovic, A., additional, Mlynarski, R., additional, Mlynarska, A., additional, Golba, K., additional, Sosnowski, M., additional, Ameta, D., additional, Goyal, M., additional, Kumar, D., additional, Chandra, S., additional, Sethi, R., additional, Puri, A., additional, Dwivedi, S. K., additional, Narain, V. S., additional, Saran, R. K., additional, Nekolla, S., additional, Rischpler, C., additional, Nicolosi, S., additional, Langwieser, N., additional, Dirschinger, R., additional, Laugwitz, K., additional, Schwaiger, M., additional, Goral, J. L., additional, Napoli, J., additional, Forcada, P., additional, Zucchiatti, N., additional, Damico, A., additional, Olivieri, D., additional, Lavorato, M., additional, Dubesarsky, E., additional, Montana, O., additional, Salgado, C., additional, Jimenez-Heffernan, A., additional, Ramos-Font, C., additional, Lopez-Martin, J., additional, Sanchez De Mora, E., additional, Lopez-Aguilar, R., additional, Manovel, A., additional, Martinez, A., additional, Rivera, F., additional, Soriano, E., additional, Maroz-Vadalazhskaya, N., additional, Trisvetova, E., additional, Vrublevskaya, O., additional, Abazid, R., additional, Kattea, M., additional, Saqqah, H., additional, Sayed, S., additional, Smettei, O., additional, Winther, S., additional, Svensson, M., additional, Birn, H., additional, Jorgensen, H., additional, Botker, H., additional, Ivarsen, P., additional, Bottcher, M., additional, Maaniitty, T., additional, Stenstrom, I., additional, Saraste, A., additional, Pikkarainen, E., additional, Uusitalo, V., additional, Ukkonen, H., additional, Kajander, S., additional, Bax, J., additional, Knuuti, J., additional, Choi, T., additional, Park, H., additional, Lee, C., additional, Lee, J., additional, Seo, Y., additional, Cho, Y., additional, Hwang, E., additional, Cho, D., additional, Sanchez Enrique, C., additional, Ferrera, C., additional, Olmos, C., additional, Jimenez - Ballve, A., additional, Perez - Castejon, M. J., additional, Fernandez, C., additional, Vivas, D., additional, Vilacosta, I., additional, Nagamachi, S., additional, Onizuka, H., additional, Nishii, R., additional, Mizutani, Y., additional, Kitamura, K., additional, Lo Presti, M., additional, Polizzi, V., additional, Pino, P., additional, Luzi, G., additional, Bellavia, D., additional, Fiorilli, R., additional, Madeo, A., additional, Malouf, J., additional, Buffa, V., additional, Musumeci, F., additional, Rosales, S., additional, Puente, A., additional, Zafrir, N., additional, Shochat, T., additional, Mats, A., additional, Solodky, A., additional, Kornowski, R., additional, Lorber, A., additional, Boemio, A., additional, Pellegrino, T., additional, Paolillo, S., additional, Piscopo, V., additional, Carotenuto, R., additional, Russo, B., additional, Pellegrino, S., additional, De Matteis, G., additional, Perrone-Filardi, P., additional, Cuocolo, A., additional, Petretta, M., additional, Amirov, N., additional, Ibatullin, M., additional, Sadykov A, A., additional, Saifullina, G., additional, Ruano, R., additional, Diego Dominguez, M., additional, Rodriguez Gabella, T., additional, Diego Nieto, A., additional, Diaz Gonzalez, L., additional, Garcia-Talavera, J., additional, Sanchez Fernandez, P., additional, Leen, A., additional, Al Younis, I., additional, Zandbergen-Harlaar, S., additional, Verberne, H., additional, Gimelli, A., additional, Veltman, C., additional, Wolterbeek, R., additional, Scholte, A., additional, Mooney, D., additional, Rosenblatt, J., additional, Dunn, T., additional, Vasaiwala, S., additional, Okuda, K., additional, Nakajima, K., additional, Nystrom, K., additional, Edenbrandt, L., additional, Matsuo, S., additional, Wakabayashi, H., additional, Hashimoto, M., additional, Kinuya, S., additional, Iric-Cupic, V., additional, Milanov, S., additional, Davidovic, G., additional, Zdravkovic, V., additional, Ashikaga, K., additional, Yoneyama, K., additional, Akashi, Y., additional, Shugushev, Z., additional, Maximkin, D., additional, Chepurnoy, A., additional, Volkova, O., additional, Baranovich, V., additional, Faibushevich, A., additional, El Tahlawi, M., additional, Elmurr, A., additional, Alzubaidi, S., additional, Sakrana, A., additional, Gouda, M., additional, El Tahlawi, R., additional, Sellem, A., additional, Melki, S., additional, Elajmi, W., additional, Hammami, H., additional, Okano, M., additional, Kato, T., additional, Kimura, M., additional, Funasako, M., additional, Nakane, E., additional, Miyamoto, S., additional, Izumi, T., additional, Haruna, T., additional, Inoko, M., additional, Massardo, T., additional, Swett, E., additional, Fernandez, R., additional, Vera, V., additional, Zhindon, J., additional, Alay, R., additional, Ohshima, S., additional, Nishio, M., additional, Kojima, A., additional, Tamai, S., additional, Kobayashi, T., additional, Murohara, T., additional, Burrell, S., additional, Van Rosendael, A., additional, Van Den Hoogen, I., additional, De Graaf, M., additional, Roelofs, J., additional, Kroft, L., additional, Rjabceva, I., additional, Krumina, G., additional, Kalvelis, A., additional, Chanakhchyan, F., additional, Vakhromeeva, M., additional, Kankiya, E., additional, Koppes, J., additional, Knol, R., additional, Wondergem, M., additional, Van Der Ploeg, T., additional, Van Der Zant, F., additional, Lazarenko, S. V., additional, Bruin, V. S., additional, Pan, X. B., additional, Declerck, J. M., additional, Van Der Zant, F. M., additional, Knol, R. J. J., additional, Juarez-Orozco, L. E., additional, Alexanderson, E., additional, Slart, R., additional, Tio, R., additional, Dierckx, R., additional, Zeebregts, C., additional, Boersma, H., additional, Hillege, H., additional, Martinez-Aguilar, M., additional, Jordan-Rios, A., additional, Christensen, T. E., additional, Ahtarovski, K. A., additional, Bang, L. E., additional, Holmvang, L., additional, Soeholm, H., additional, Ghotbi, A. A., additional, Andersson, H., additional, Ihlemann, N., additional, Kjaer, A., additional, Hasbak, P., additional, Gulya, M., additional, Lishmanov, Y. B., additional, Zavadovskii, K., additional, Lebedev, D., additional, Stahle, M., additional, Hellberg, S., additional, Liljenback, H., additional, Virta, J., additional, Metsala, O., additional, Yla-Herttuala, S., additional, Saukko, P., additional, Roivainen, A., additional, Thackeray, J., additional, Wang, Y., additional, Bankstahl, J., additional, Wollert, K., additional, Bengel, F., additional, Saushkina, Y., additional, Evtushenko, V., additional, Minin, S., additional, Efimova, I., additional, Evtushenko, A., additional, Smishlyaev, K., additional, Lishmanov, Y., additional, Maslov, L., additional, Kirihara, Y., additional, Sugino, S., additional, Taki, J., additional, Ahmadian, A., additional, Berman, J., additional, Govender, P., additional, Ruberg, F., additional, Miller, E., additional, Piriou, N., additional, Pallardy, A., additional, Valette, F., additional, Cahouch, Z., additional, Mathieu, C., additional, Warin-Fresse, K., additional, Gueffet, J., additional, Serfaty, J., additional, Trochu, J., additional, Kraeber-Bodere, F., additional, Van Dijk, J., additional, Van Dalen, J., additional, Ofrk, H., additional, Vaturi, M., additional, Hassid, Y., additional, Belzer, D., additional, Sagie, A., additional, Kaminek, M., additional, Metelkova, I., additional, Budikova, M., additional, Koranda, P., additional, Henzlova, L., additional, Sovova, E., additional, Kincl, V., additional, Drozdova, A., additional, Jordan, M., additional, Shahid, F., additional, Teoh, Y., additional, Thamen, R., additional, Hara, N., additional, Onoguchi, M., additional, Hojyo, O., additional, Kawaguchi, Y., additional, Murai, M., additional, Udaka, F., additional, Matsuzawa, Y., additional, Bulugahapitiya, D. S., additional, Avison, M., additional, Martin, J., additional, Liu, Y.-H., additional, Wu, J., additional, Liu, C., additional, Sinusas, A., additional, Daou, D., additional, Sabbah, R., additional, Bouladhour, H., additional, Coaguila, C., additional, Aguade-Bruix, S., additional, Pizzi, M., additional, Romero-Farina, G., additional, Candell-Riera, J., additional, Castell-Conesa, J., additional, Patchett, N., additional, Sverdlov, A., additional, Boulaamayl El Fatemi, S., additional, Sallam, L., additional, Snipelisky, D., additional, Park, J., additional, Ray, J., additional, Shapiro, B., additional, Kostkiewicz, M., additional, Szot, W., additional, Holcman, K., additional, Lesniak-Sobelga, A., additional, Podolec, P., additional, Clerc, O., additional, Possner, M., additional, Liga, R., additional, Vontobel, J., additional, Mikulicic, F., additional, Graeni, C., additional, Benz, D., additional, Herzog, B., additional, Gaemperli, O., additional, and Kaufmann, P., additional

Published
2015
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8. Combined hormone replacement therapy improves endothelial function in healthy postmenopausal women

Author

Guzic-Salobir B, Irena Keber, I. Seljeflot, H. Arnesen, and L. Vrabič

Subjects
medicine.medical_specialty, Endothelium, Brachial Artery, medicine.medical_treatment, Urology, Vasodilation, Placebo, Statistics, Nonparametric, Double-Blind Method, Internal medicine, medicine.artery, Epidemiology, Internal Medicine, medicine, Humans, Prospective Studies, Brachial artery, Analysis of Variance, Estradiol, business.industry, Estrogen Replacement Therapy, Hormone replacement therapy (menopause), Middle Aged, Norethisterone acetate, Postmenopause, Drug Combinations, Norethindrone Acetate, Endocrinology, medicine.anatomical_structure, Circulatory system, Female, Endothelium, Vascular, Norethindrone, business, Cell Adhesion Molecules, medicine.drug
Abstract

Gužic-Salobir B, Keber I, Seljeflot I, Arnesen H, Vrabic L (University Medical Centre, Ljubljana, Slovenia; Ullevaal University Hospital, Oslo, Norway; and Novo Nordisk A/S, Ljubljana, Slovenia). Combined hormone replacement therapy improves endothelial function in healthy postmenopausal women. J Intern Med 2001; 250: 508–515. Objectives. Large scale epidemiological studies suggest that hormone replacement therapy (HRT) reduces cardiovascular events in postmenopausal women. Improvement in endothelial function may contribute to this protective effect. Design. In a prospective, double blind study, 61 healthy postmenopausal women were randomized to receive either oral continuous combined HRT [oestradiol 2 mg and norethisterone acetate (NETA) 1 mg per day] or placebo. Endothelial function, assessed by flow-mediated vasodilation (FMD) of the brachial artery and expression of soluble endothelial cell adhesion molecules (CAM) were determined before, after 3 and 6 months of therapy. Results. The FMD was significantly improved in women on combined HRT (from 5.97% to 10.94% after 3 months and to 10.58% after 6 months; both P

Published
2002

11. Impairment of myocardial perfusion correlates with heart failure severity in patients with non-compaction cardiomyopathy.

Author

Cerar A, Jaklic M, Frljak S, Poglajen G, Zemljic G, Guzic Salobir B, Dolenc Novak M, Stalc M, Zbacnik R, and Kozelj M

Subjects
Female, Humans, Male, Perfusion, Stroke Volume, Ventricular Function, Left, Cardiomyopathies complications, Cardiomyopathies diagnosis, Heart Failure diagnosis
Abstract

Aims: Non-compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients., Methods and Results: We enrolled 41 NCM patients (28 male and 13 female), aged 21-70 years. In all patients, we have determined left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been measured, and myocardial single-photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (-9.9 ± 5.2% vs. -14.5 ± 4.1%, P = 0.001), and higher NT-proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = -0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT-proBNP (r = 0.66, P < 0.001)., Conclusions: The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation., (© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2020
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