1. Gastric neuroendocrine tumors: 20‐Year experience in a reference center
- Author
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Ravizza, D, Giunta, M, Sala, I, Bagnardi, V, Tamayo, D, de Roberto, G, Trovato, C, Bravi, I, Soru, P, Maregatti, M, Pisa, E, Bertani, E, Bonomo, G, Spada, F, Nicola, F, Ravizza, Davide, Giunta, Mariangela, Sala, Isabella, Bagnardi, Vincenzo, Tamayo, Darina, de Roberto, Giuseppe, Trovato, Cristina, Bravi, Ivana, Soru, Pietro, Maregatti, Margherita, Pisa, Eleonora, Bertani, Emilio, Bonomo, Guido, Spada, Francesca, Nicola, Fazio, Ravizza, D, Giunta, M, Sala, I, Bagnardi, V, Tamayo, D, de Roberto, G, Trovato, C, Bravi, I, Soru, P, Maregatti, M, Pisa, E, Bertani, E, Bonomo, G, Spada, F, Nicola, F, Ravizza, Davide, Giunta, Mariangela, Sala, Isabella, Bagnardi, Vincenzo, Tamayo, Darina, de Roberto, Giuseppe, Trovato, Cristina, Bravi, Ivana, Soru, Pietro, Maregatti, Margherita, Pisa, Eleonora, Bertani, Emilio, Bonomo, Guido, Spada, Francesca, and Nicola, Fazio
- Abstract
Few studies have been published on the long-term outcomes of patients with gastric neuroendocrine tumors (gNETs). We analyzed their management over a two-decade period, focusing on endoscopic and clinical outcomes. Clinical, laboratory, endoscopic, surgical, and histopathological data from Types 1 and 3 gNETs histologically diagnosed between March 2000 and December 2021 at the European Institute of Oncology (IEO, Milan) were retrospectively collected. Sixty-nine patients were included (60 Type 1, 9 Type 3): 53 (77%) were treated endoscopically, 6 (9%) surgically, and 10 (14%) did not receive any treatment. Overall, 293 lesions were removed endoscopically: 74% by forceps, 20% by endoscopic mucosal resection (EMR), and 5% by endoscopic submucosal dissection (ESD). No differences were observed between EMR and ESD in terms of complete resection rate (p value = .50) and complications rate (p value = .084). The median follow-up period was 5.8 years (range: 0.3-20.5), during which no gNET-related deaths were observed. Metachronous gNETs developed in 60% of patients with Type 1 gNET. Six patients with lymph node metastases (LNM) were younger (p value = .006) and had larger lesions (p value <.001) than patients without LNM. Most Type 1 gNETs were successfully excised using forceps, with EMR and ESD being equally effective. The presence of incomplete resection was not associated with a worse prognosis, which remains excellent in this highly recurrent disease. Younger age and a size ≥10 mm were associated with an increased risk of LNM. CLINICAL TRIAL REGISTRATION: Project code UID 2854.
- Published
- 2024