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Formulation of sustainable resource-based organic-inorganic hybrid protective coatings have been achieved using Linseed oil-based silica hybrid with terpolymer (TP) as basic skeletal matrix. The fabrication of TP system was performed by using systematic one pot multi-facile steps (diol fatty amide-linseed oil-based polyester amide TP) synthesis route. The conversion of ester amide functional ends of TP to urethane was initiated to enhance adhesiveness, impermeability, and corrosion resistivity of the processed hybrid material. FT-IR and NMR ([sup.1]H, [sup.13]C, and [sup.29]Si) studies help in verifying the chemical structure and progress of the reaction. The formulation of smooth corrosion resistive coating was further analyzed by transmission electron microscopy, scanning electron microscope, and electrochemical corrosion studies. The in-situ tethering and homogeneous dispersion of inorganic moiety in nanoregime throughout the TP system further enhances the stability, wettability, and corrosion protection ability of the nanohybrid vegetable oil-based coating under corrosive environment. High phase angle value at higher frequency end indicates the stability of the coating system. Such coating systems composed of sustainable resource with improved mechanical, thermal, and corrosion protective properties have great potential in future applications. KEYWORDS corrosion, nanocomposite, renewable, seed oil, terpolymer, 1 | INTRODUCTION The ever-rising pollution and corrosive environment around have been enforcing the need to use greener alternatives such as vegetable oil (VO)-derived products. [1,2] The engineered VO products [...]

This research work deployed free radical polymerization for the development of pH-responsive hybrid nanocomposite hydrogels (NCHs) with the formation of improved interpenetrating networks (IPN). The crosslinked biopolymeric system was composed of (chitosan (CH)/guar gum (GG)/polyol) and a nanofiller (Cloisite 30B). The study was aimed to investigate the role of Cloisite 30B as a nanofiller and linseed oil-derived polyol to induce stable interpenetrating networks in chitosan‒guar gum-based hydrogels. FT-IR analysis confirmed the formation of crosslinked networks with the formation of hydrogen bonds in the synthesized NCHs. Thermogravimetric analysis and differential scanning calorimetry revealed high thermal stability of the NCHs. The hydrolytic and soil burial degradation tests confirmed the biodegradability of the synthesized NCHs. An extraordinarily high swelling capacity in a buffer solution of pH 4.0 and 7.4 demonstrated their pH-responsive behavior. It has been demonstrated that even the minimal addition of polyol to the guar gum-based hydrogels has influenced the stability and characteristic features such as high swelling capacity owing to the formation of interpenetrating networks and the biodegradability of the hydrogels., Competing Interests: The authors declare no conflict of interest.

The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T 1 contrast agent for high-resolution magnetic resonance imaging (MRI) is highly desirable. However, the correlations between the chemical compositions, in vitro T 1 relaxivities, in vivo nano-bio interactions and toxicities remain unclear, which has been a challenge in optimizing the in vivo T 1 contrast efficacy. Methods : Ultrasmall (3 nm) manganese ferrite nanoparticles (Mn x Fe 3-x O 4 ) with different doping concentrations of the manganese ions (x = 0.32, 0.37, 0.75, 1, 1.23 and 1.57) were used as a model system to investigate the composition-dependence of the in vivo T 1 contrast efficacy. The efficacy of liver-specific contrast-enhanced MRI was assessed through systematic multiple factor analysis, which included the in vitro T 1 relaxivity, in vivo MRI contrast enhancement, pharmacokinetic profiles (blood half-life time, biodistribution) and biosafety evaluations ( in vitro cytotoxicity testing, in vivo blood routine examination, in vivo blood biochemistry testing and H&E staining to examine the liver). Results : With increasing Mn doping, the T 1 relaxivities initially increased to their highest value of 10.35 mM -1 s -1 , which was obtained for Mn 0.75 Fe 2.25 O 4 , and then the values decreased to 7.64 m M -1 s -1 , which was obtained for the Mn 1.57 Fe 1.43 O 4 nanoparticles. Nearly linear increases in the in vivo MRI signals (ΔSNR) and biodistributions (accumulation in the liver) of the Mn x Fe 3-x O 4 nanoparticles were observed for increasing levels of Mn doping. However, both the in vitro and in vivo biosafety evaluations suggested that Mn x Fe 3-x O 4 nanoparticles with high Mn-doping levels (x > 1) can induce significant toxicity. Conclusion : The systematic multiple factor assessment indicated that the Mn x Fe 3-x O 4 (x = 0.75-1) nanoparticles were the optimal T 1 contrast agents with higher in vivo efficacies for liver-specific MRI than those of the other compositions of the Mn x Fe 3-x O 4 nanoparticles. Our work provides insight into the optimization of ultrasmall ferrite nanoparticle-based T 1 contrast agents by tuning their compositions and promotes the translation of these ultrasmall ferrite nanoparticles for clinical use of high-performance contrast-enhanced MRI., Competing Interests: Competing Interests: The authors have declared that no competing interest exists.