26 results on '"Gasparri, G."'
Search Results
2. M. Dobre, Descartes and early Cartesianism. Between metaphysics and physics, Bucharest, Zeta Books, 2017
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Gasparri, G.
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fisica ,metafisica ,Descartes ,cartesianismo - Published
- 2019
3. Diagnostic, therapeutic and healthcare management protocols in thyroid surgery: 3rd Consensus Conference of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB)
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Rosato L, De Toma G, Bellantone R, Avenia N, Cavallaro G, Dobrinja C, Maria Grazia Chiofalo, De Crea C, De Palma M, Gasparri G, Gurrado A, Lombardi C, Miccoli P, Mullineris B, Pg, Nasi, Pelizzo MR, Pezzullo L, Perigli G, Testini M, and Associazione delle Unità di Endocrinochirurgia Italiana
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Parathyroidectomy ,Hyperparathyroidism ,Preoperative work up ,protocols ,Postoperative management ,Hyperparathyroidism, Parathyroid disease, Parathyroidectomy, Postoperative management, Preoperative work up ,Thyroid Diseases ,thyroid ,Diagnostic ,therapeutic ,management ,surgery ,Clinical Protocols ,Thyroidectomy ,Parathyroid disease ,Humans - Published
- 2012
4. PROTOCOLLI GESTIONALI DIAGNOSTICO-TERAPEUTICO-ASSITENZIALI IN CHIRURGIA TIROIDEA
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Rosato, L, Miccoli, P, Pinchera, A, Lombardi, G, Romano, M, Avenia, N, Bastagli, A, Bellantone, R, DE PALMA, M, DE TOMA, Giorgio, Gasparri, G, Lampugnani, R, Marini, Pl, Nasi, Pg, Pelizzo, Mr, Pezzullo, L, Piccoli, M, and Testini, M.
- Published
- 2009
5. Diagnostic, therapeutic and healthcare management protocols in parathyroidsurgery. 1st Consensus Conference
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Rosato, L, Pinchera, A, Pellizzo, Mr, De Antoni, E, Miccoli, P, Avenia, N, Gasparri, G, Bellantone, R, Lampugnani, R, Nasi, Pg, Pontecorvi, A, Bastagli, A, De Palma, M, Faragona, S, Livrea, A, Pezzullo, L, Taffurelli, M, Torre, G, Letizia, Claudio, Ardito, G, DE TOMA, Giorgio, and Italian Association of Endocrine Surgery Units (UEC
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- 2008
6. Diagnostic, therapeutic and healthcare management protocols in thyroid surgery. 2nd Consensus Conference (U.E.C. CLUB)
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Rosato, L, Miccoli, P, Pinchera, A, Lombardi, G, Romano, M, Avenia, N, Bastagli, A, Bellantone, Rocco Domenico Alfonso, De Palma, M, De Toma, G, Gasparri, G, Lampugnani, R, Marini, Pl, Nasi, Pg, Pellizzo, Mr, Pezzullo, L, Piccoli, M, Testini, M., Bellantone, Rocco Domenico Alfonso (ORCID:0000-0002-0844-3469), Rosato, L, Miccoli, P, Pinchera, A, Lombardi, G, Romano, M, Avenia, N, Bastagli, A, Bellantone, Rocco Domenico Alfonso, De Palma, M, De Toma, G, Gasparri, G, Lampugnani, R, Marini, Pl, Nasi, Pg, Pellizzo, Mr, Pezzullo, L, Piccoli, M, Testini, M., and Bellantone, Rocco Domenico Alfonso (ORCID:0000-0002-0844-3469)
- Abstract
AIM: To review and to update the management protocols in thyroid surgery proposed two years ago by 1st Consensus Conference called on the topic by the Italian Association of Endocrine Surgery Units (UEC Club). METHOD: The 2nd Consensus Conference took place November 30, 2008 in Pisa within the framework of the 7th National Congress of the UEC Club. A selected board of endocrinologists and endocrine surgeons (chairmans: Paolo Miccoli and Aldo Pinchera; speaker: Lodovico Rosato) examined the individual chapters and submitted the consensus text for the approval of several experts. This plain and concise text provides the rationale of the thyroid patient management and wants to be the most complete possible tool for the physicians and other professionals in the field. CONCLUSIONS: The diagnostic, therapeutic and healthcare management protocols in thyroid surgery approved by the 2nd Consensus Conference are officially those proposed by the Italian Association of Endocrine Surgery Units (UEC Club) and are subject to review by two years.
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- 2009
7. Structural research on non transition metal double nitrites: Crystal structure, optical absorption and emission of TlBa(NO).
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Gasparri, G., Nardelli, M., and Fermi, F.
- Abstract
The thallium-barium double nitrite, TlBa(NO)5, is pyroelectric in the 77-600 K range and crystallizes in the Pca2 space group. The lattice constants at 293 K are: a = 17.868(12), b = 4.934(3), c = 13-426(11) A (MoKa, λ = 0.71069 A). There are four stoichiometric units in the unit cell of volume V= 1184(1) A ( D = 3.98, D = 3.979 Mgm), F (000) = 1232, μ = 20.36mm. The crystal structure was solved by Patterson and Fourier methods and refined by least-squares to a final conventional agreement index R = 0.053 for 1371 independent reflections collected in a θ range of 3-30°, using MoKα radiation. There are two independent barium atoms surrounded by NO groups, both with coordination number 10 and distances in the ranges Ba-O = 2.69(4)-3.18(4) A and Ba-N = 3.01(4)-3.18(4) A. The environment of thallium is clearly affected by the lone-pair stereoactivity and involves 12 Tl-O and Tl-N contacts less than 3.5A, but only four Tl-O distances are shorter than 3 A (min. 2.76(2), max. 2.85(3) A), with a pyramidal coordination and thallium at the apex of the pyramid. All these coordination polyhedra are joined in chains running along the shortest lattice vector [010]. The single crystal electronic spectra, studied in absorption with polarized light and in photostimulated emission, are interpreted as due to transitions involving NO electronic levels perturbed by Tl, whose spin-orbit interaction makes probable also the forbidden singlet-triplet transitions, in agreement with the interpretative picture given for post-transition metal nitrites. [ABSTRACT FROM AUTHOR]
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- 1984
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8. Ligand configuration and coordination geometry in silver(I)-thiosemicarbazide complexes.
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Corradi Bonamartini, A., Fava Gasparri, G., Ferrari Belicchi, M., and Nardelli, M.
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- 1987
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9. Structure of dinitratobis(triphenylphosphine oxide)copper(II) toluene solvate (1/1).
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Ferrari, M. B., Gasparri, G. F., Pelizzi, C., and Tarasconi, P.
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- 1986
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10. Analysis Of Series Elasticity In Locomotion Of A Planar Bipedal Robot
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Manara, S., Gasparri, G. M., manolo garabini, Caporale, D., Gabiccini, M., and Bicchi, A.
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Optimal Control ,Soft Robotics, Series Elasticity, Locomotion, Optimal Control ,Soft Robotics ,Series Elasticity ,Locomotion
11. Le opportunità offerte dalle innovazioni tecnologiche nell’ambito del diritto delle società quotate: profili introduttivi
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ANDREA ZOPPINI, M. Bianchini, G. Gasparri, G. Resta, G. Trovatore, A. Zoppini, and Zoppini, Andrea
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- 2022
12. Topic: Incisional Hernia - 'Easy case' as daily case: open vs lap, where the mesh, which fixation…in center midline cases
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J, Yunis, K, Yamamoto, Y, Morishima, D, Satomi, Y, Toshimitsu, S, Fukutomi, M, Sakakibara, M, Mori, K, Ishige, J, Kobayashi, M, Uccelli, F, Ciccarese, G, Cesana, G, Castello, D, Carrieri, G, Grava, S, Olmi, G, Soliani, A, De Troia, P, Carcoforo, M, Portinari, G, Vasquez, S, Targa, C V, Feo, B Simões, Duarte de Castro L, T, Brito, D, Gomes, L, Calais, M, Ferreira, A, Gonçalves, A, Martins, M, Gonçalves, A, Rodrigues, R, Rodrigues, T, Almeida, J, Ventura, C, Lucas, A, Midões, S, Pileci, M, Giaccone, M, Brunetti, M, Camandona, G, Gasparri, M, Ucceli, G, Legnani, Y, Nakabayashi, A, Harada, Y, Fujiwara, H, Sugano, N, Matsumoto, R, Noaki, K, Kurihara, M, Otsuka, C, Mavrodin, G, Pariza, I, Antoniac, A, Dirican, M, Ates, V, Soyer, B, Sarici, E, Kinaci, S, Yilmaz, M, Matsumoto, K, Kazunao, S, Demiryas, I, Demir, Y, Kucuk, V, Umman, A, Orhan, A K, Zengin, M, Ertem, I, Tasci, M, Christoffersen, E, Brandt, J, Oehlenschläger, J, Rosenberg, F, Helgstrand, L N, Jørgensen, L, Bardram, T, Bisgaard, G, Bellanova, R, Valduga, R, Beltempo, G, Berlanda, F A, Ciarleglio, R, Bondioli, S, Marcucci, C, Prezzi, A, Brolese, Yunis, J, Yamamoto, K, Morishima, Y, Satomi, D, Toshimitsu, Y, Fukutomi, S, Sakakibara, M, Mori, M, Ishige, K, Kobayashi, J, Uccelli, M, Ciccarese, F, Cesana, G, Castello, G, Carrieri, D, Grava, G, Olmi, S, Soliani, G, De Troia, A, Carcoforo, P, Portinari, M, Vasquez, G, Targa, S, Feo, C V, Duarte de Castro L, B Simõe, Brito, T, Gomes, D, Calais, L, Ferreira, M, Gonçalves, A, Martins, A, Gonçalves, M, Rodrigues, A, Rodrigues, R, Almeida, T, Ventura, J, Lucas, C, Midões, A, Pileci, S, Giaccone, M, Brunetti, M, Camandona, M, Gasparri, G, Ucceli, M, Legnani, G, Nakabayashi, Y, Harada, A, Fujiwara, Y, Sugano, H, Matsumoto, N, Noaki, R, Kurihara, K, Otsuka, M, Mavrodin, C, Pariza, G, Antoniac, I, Dirican, A, Ates, M, Soyer, V, Sarici, B, Kinaci, E, Yilmaz, S, Matsumoto, M, Kazunao, K, Demiryas, S, Demir, I, Kucuk, Y, Umman, V, Orhan, A, Zengin, A K, Ertem, M, Tasci, I, Christoffersen, M, Brandt, E, Oehlenschläger, J, Rosenberg, J, Helgstrand, F, Jørgensen, L N, Bardram, L, Bisgaard, T, Bellanova, G, Valduga, R, Beltempo, R, Berlanda, G, Ciarleglio, F A, Bondioli, R, Marcucci, S, Prezzi, C, and Brolese, A
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Surgery - Published
- 2015
13. Diagnostic, therapeutic and healthcare management protocols in parathyroid surgery: II Consensus Conference of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB)
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Rocco Domenico Alfonso Bellantone, Giovanni Conzo, Claudio Marcocci, M. L. Brandi, P. G. Nasi, Paolo Miccoli, Giuliano Mariani, Alfredo Pontecorvi, Maria Grazia Chiofalo, Maria Rosa Pelizzo, Raffaele Paragliola, Filomena Cetani, Guido Gasparri, Nadia Innaro, Marco Raffaelli, Alessandro Giordano, M. De Palma, E. Leopaldi, M. Boniardi, Furio Pacini, G. De Toma, Mario Testini, P. L. Marini, Luca Rosato, Nicola Avenia, Rosato, L, Raffaelli, M, Bellantone, R, Pontecorvi, A, Avenia, N, Boniardi, M, Brandi, Ml, Cetani, F, Chiofalo, Mg, Conzo, Giovanni, De Palma, M, Gasparri, G, Giordano, A, Innaro, N, Leopaldi, E, Mariani, G, Marcocci, C, Marini, Pl, Miccoli, P, Nasi, Pg, Pacini, F, Paraglioli, Rm, Pelizzo, Mr, Testini, M, and De Toma, G.
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medicine.medical_specialty ,Consensus ,Waiting Lists ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Parathyroid Diseases ,Time to treatment ,protocols ,Directive Counseling ,Health administration ,Time-to-Treatment ,surgery ,Consent Forms ,Parathyroid Glands ,Endocrinology ,Medicine ,Humans ,parathyroid ,Diagnostic ,Parathyroid disease ,Parathyroidectomy ,business.industry ,General surgery ,Consensus conference ,medicine.disease ,hyperparathyroidism ,postoperative management ,parathyroidectomy ,parathyroid disease ,preoperative work up ,Surgery ,Endocrine surgery ,Critical Pathways ,Delivery of Health Care ,Hospitalization ,Practice Guidelines as Topic ,therapeutic ,healthcare management ,hyperparathyroidism, parathyroid disease, parathyroidectomy, preoperative work up, postoperative management ,Club ,Parathyroid surgery ,business - Abstract
Aim To update the Diagnostic-Therapeutic-Healthcare Protocol (Protocollo Diagnostico-Terapeutico-Assistenziale, PDTA) created by the U.E.C. CLUB (Association of the Italian Endocrine Surgery Units) during the I Consensus Conference in 2008. Methods In the preliminary phase, the II Consensus involved a selected group of experts; the elaboration phase was conducted via e-mail among all members; the conclusion phase took place during the X National Congress of the U.E.C. CLUB. The following were examined: diagnostic pathway and clinical evaluation; mode of admission and waiting time; therapeutic pathway (patient preparation for surgery, surgical treatment, postoperative management, management of major complications); hospital discharge and patient information; outpatient care and follow-up. Conclusions The PDTA for parathyroid surgery approved by the II Consensus Conference (June 2013) is the official PDTA of the U.E.C. CLUB.
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- 2014
14. Il Chronicon di Santa Maria del Principio (1313 circa) e la messa in scena della liturgia nel cuore della Cattedrale di Napoli
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LUCHERINI, VINCENZA, C. GASPARRI, G. GRECO, R. PIEROBON BENOIT, and Lucherini, Vincenza
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Liturgia ,cattedrale Napoli ,architettura - Abstract
Nell'articolo si analizza un testo liturgico, mai analizzato nel suo complesso, tramandato da un unico codice conservatosi nell'Archivio diocesano di Napoli. Il testo si analizza al fine di dedurne informazioni utili alla ricostruzione della facies architettonica della cattedrale di Napoli nel Medioevo.
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- 2010
15. Problems in reconstructive surgery in the treatment of carcinoma of the hypopharyngoesophageal junction
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Mario Bussi, Giorgio Cortesina, Guido Gasparri, V. Ferrero, E. Riontino, Michele Camandona, Bussi, Mario, Ferrero, V, Riontino, E, Gasparri, G, Camandona, M, Cortesina, G., V., Ferrero, E., Riontino, G., Gasparri, M., Camandona, and G., Cortesina
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Male ,medicine.medical_specialty ,Reconstructive surgery ,Esophageal Neoplasms ,Colon ,medicine.medical_treatment ,Piriform sinus ,Pharyngectomy ,Gastrectomy ,Carcinoma ,Medicine ,Humans ,Radical surgery ,Esophagus ,Aged ,Hypopharyngeal Neoplasms ,business.industry ,General Medicine ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Surgery ,Esophagectomy ,Survival Rate ,Plastic surgery ,medicine.anatomical_structure ,Oncology ,Neck Dissection ,Female ,business ,Follow-Up Studies - Abstract
Background and objectives Thirty percent of carcinomas of the pyriform sinus manifest generally with infiltrations in the cervical esophagus. In recent years, progress in reconstructive surgery has broadened surgical indications to include tumors previously managed with palliative measures alone. In some cases, radical surgery has been extended to creating safer resection margins, with more and more indications for circular pharyngectomy. Lesions involving the hypopharyngoesophageal junction pose particular problems; furthermore, the high rate of synchronous or metachronous tumors warrants the indication for total esophagectomy, which requires complex reconstructive techniques. Methods We report on a series of 21 patients who underwent pharyngocoloplasties after receiving total pharyngolaryngoesophagectomy. Results With regard to the oncologic results, after a follow-up of 2-60 months, 9 patients had no evidence of disease, 5 patients died during the postoperative course, 2 patients survived with disease, 4 died with disease, 1 died from metachronous breast carcinoma, and 7 underwent reintervention. Conclusions In cases in which reconstruction by gastric pull-up is considered risky, if not contraindicated, pharyngocoloplasty represents a particularly reliable treatment option. The limits and advantages of the technique are discussed. The procedure permitted us to reconstruct the digestive tract, without encountering problems any more serious than those a normal gastric pull-up procedure would pose.
- Published
- 2000
16. Climate finance opportunities for health and health systems.
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Borghi J, Cuevas Garcia-Dorado S, Anton B, Gerardo D, Gasparri G, Hanson M, Soucat A, Bustreo F, and Langlois EV
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- Humans, Delivery of Health Care economics, Delivery of Health Care organization & administration, Climate Change economics, Global Health
- Abstract
Climate change poses significant risks to health and health systems, with the greatest impacts in low- and middle-income countries - which are least responsible for greenhouse gas emissions. The Conference of Parties 28 at the 2023 United Nations Climate Change Conference led to agreement on the need for holistic and equitable financing approaches to address the climate and health crisis. This paper provides an overview of existing climate finance mechanisms - that is, multilateral funds, voluntary market-based mechanisms, taxes, microlevies and adaptive social protection. We discuss these approaches' potential use to promote health, generate additional health sector resources and enhance health system sustainability and resilience, and also explore implementation challenges. We suggest that public health practitioners, policy-makers and researchers seize the opportunity to leverage climate funding for better health and sustainable, climate-resilient health systems. Emphasizing the wider benefits of investing in health for the economy can help prioritize health within climate finance initiatives. Meaningful progress will require the global community acknowledging the underlying political economy challenges that have so far limited the potential of climate finance to address health goals. To address these challenges, we need to restructure financing institutions to empower communities at the frontline of the climate and health crisis and ensure their needs are met. Efforts from global and national level stakeholders should focus on mobilizing a wide range of funding sources, prioritizing co-design and accessibility of financing arrangements. These stakeholders should also invest in rigorous monitoring and evaluation of initiatives to ensure relevant health and well-being outcomes are addressed., ((c) 2024 The authors; licensee World Health Organization.)
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- 2024
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17. Opportunities and challenges for financing women's, children's and adolescents' health in the context of climate change.
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Anton B, Cuevas S, Hanson M, Bhutta ZA, Langlois EV, Iaia DG, Gasparri G, and Borghi J
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- Humans, Adolescent, Female, Child, Healthcare Financing, Developing Countries, Climate Change economics, Child Health economics, Adolescent Health economics, Women's Health economics
- Abstract
Women, children and adolescents (WCA), especially in low-income and middle-income countries (LMICs), will bear the worst consequences of climate change during their lifetimes, despite contributing the least to global greenhouse gas emissions. Investing in WCA can address these inequities in climate risk, as well as generating large health, economic, social and environmental gains. However, women's, children's and adolescents' health (WCAH) is currently not mainstreamed in climate policies and financing. There is also a need to consider new and innovative financing arrangements that support WCAH alongside climate goals.We provide an overview of the threats climate change represents for WCA, including the most vulnerable communities, and where health and climate investments should focus. We draw on evidence to explore the opportunities and challenges for health financing, climate finance and co-financing schemes to enhance equity and protect WCAH while supporting climate goals.WCA face threats from the rising burden of ill-health and healthcare demand, coupled with constraints to healthcare provision, impacting access to essential WCAH services and rising out-of-pocket payments for healthcare. Climate change also impacts on the economic context and livelihoods of WCA, increasing the risk of displacement and migration. These impacts require additional resources to support WCAH service delivery, to ensure continuity of care and protect households from the costs of care and enhance resilience. We identify a range of financing solutions, including leveraging climate finance for WCAH, adaptive social protection for health and adaptations to purchasing to promote climate action and support WCAH care needs., Competing Interests: Competing interests: None declared., (© World Health Organization 2024. Licensee BMJ.)
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- 2024
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18. Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour.
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Gurrado A, Pasculli A, Avenia N, Bellantone R, Boniardi M, Merante Boschin I, Calò PG, Camandona M, Cavallaro G, Cianchi F, Conzo G, D'Andrea V, De Crea C, De Pasquale L, Del Rio P, Di Meo G, Dionigi G, Dobrinja C, Docimo G, Famà F, Galimberti A, Giacomelli L, Graceffa G, Iacobone M, Innaro N, Lombardi CP, Materazzi G, Medas F, Mullineris B, Oragano L, Palestini N, Perigli G, Pezzolla A, Prete FP, Raffaelli M, Renzulli G, Rosato L, Scerrino G, Sgaramella LI, Sorrenti S, Testini C, Veroux M, Gasparri G, and Testini M
- Abstract
Background: Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the atypical parathyroid tumour (APT)., Methods: All relevant information was collected about PC and APT patients treated between 2009 and 2021., Results: Among 8361 parathyroidectomies, 351 patients (mean age 59.0 ± 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates ( p < 0.05) of bone involvement, abdominal, and neurological symptoms than APT (48.8% vs. 35.0%, 17.6% vs. 7.1%, 13.6% vs. 5.3%, respectively). Ultrasound (US) diameter >3 cm (30.9% vs. 19.3%, p = 0.049) was significantly more common in the PC. A significantly higher frequency of local recurrences was observed in the PC (8.0% vs. 2.7%, p = 0.022). Mortality due to consequences of cancer or uncontrolled hyperparathyroidism was 3.3%., Conclusions: Symptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis.
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- 2023
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19. Integrating Youth Perspectives: Adopting a Human Rights and Public Health Approach to Climate Action.
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Gasparri G, Tcholakov Y, Gepp S, Guerreschi A, Ayowole D, Okwudili ÉD, Uwandu E, Sanchez Iturregui R, Amer S, Beaudoin S, and Sato M
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- Adolescent, Child, Climate Change, Humans, Human Rights, Public Health
- Abstract
Climate change is a multidimensional issue that affects all aspects of society, including public health and human rights. Climate change is already severely impacting people's health and threatening people's guaranteed fundamental rights, including those to life, health, self-determination, and education, among others. Across geographical regions, population groups and communities who are already marginalized due to age, gender, ethnicity, income, and other socioeconomic factors, are those who are disproportionately affected by climate impacts despite having contributed the least to global emissions. Although scholars have been calling for a human rights-based approach and a health perspective to climate action, the literature looking at this multidisciplinary intersection is still nascent, and governments have yet to implement such intersectoral policies. This commentary begins to reflect on the relationship between climate change, human rights, and public health from the perspective of young people engaged in climate action and discourse at the national and international levels. It presents a way forward on what we, as youth climate advocates and researchers, believe is a priority to bring intersectoral integration of human rights and public health approaches to climate change to fruition. First, scholars and practitioners should examine and support youth-led climate interventions that tackle human rights and public health violations incurred by the climate crisis. Second, participatory approaches to climate change must be designed by working synergistically with climate-vulnerable groups, including children and young people, practitioners and scholars in public health and human rights sectors to holistically address the social, health, and environmental impacts of the climate crisis and root causes of injustice. Finally, we recommend more holistic data collection to better inform evidence-based climate policies that operationalize human rights and public health co-benefits.
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- 2022
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20. Children, Adolescents, and Youth Pioneering a Human Rights-Based Approach to Climate Change.
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Gasparri G, Omrani OE, Hinton R, Imbago D, Lakhani H, Mohan A, Yeung W, and Bustreo F
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- Adolescent, Child, Humans, Social Justice, Social Responsibility, Climate Change, Human Rights
- Abstract
Climate change is the greatest challenge of our century. Children, adolescents, and youth will bear the most severe impacts, physically, socially, economically, and psychologically. In response to this immense threat and to the failure of international climate negotiations to date, young people are taking to the streets and using global fora to call for climate justice. While these protests have received much attention, there has been limited examination of these and other youth-led efforts through the lens of a human rights-based approach and its operational principles: participation, equality and nondiscrimination, accountability, and transparency. This paper draws from academic and gray literature, as well as the authors' experience as practitioners and young activists, to argue that young people, by promoting human rights-based operational principles at the international, national, and local levels, are pioneering a human rights-based approach to climate change. The paper concludes by suggesting how policy makers can support and empower young people to advance an explicit human rights-based agenda, while concurrently translating human rights-based operational principles into climate change policies and practice., Competing Interests: Competing interests: None declared., (Copyright © 2021 Gasparri, El Omrani, Hinton, Imbago, Lakhani, Mohan, Yeung, and Bustreo.)
- Published
- 2021
21. Risks and Opportunities of RegTech and SupTech Developments.
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Gasparri G
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- 2019
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22. Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement.
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Garberoglio R, Aliberti C, Appetecchia M, Attard M, Boccuzzi G, Boraso F, Borretta G, Caruso G, Deandrea M, Freddi M, Gallone G, Gandini G, Gasparri G, Gazzera C, Ghigo E, Grosso M, Limone P, Maccario M, Mansi L, Mormile A, Nasi PG, Orlandi F, Pacchioni D, Pacella CM, Palestini N, Papini E, Pelizzo MR, Piotto A, Rago T, Riganti F, Rosato L, Rossetto R, Scarmozzino A, Spiezia S, Testori O, Valcavi R, Veltri A, Vitti P, and Zingrillo M
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- 2015
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23. CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer.
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Cetani F, Banti C, Pardi E, Borsari S, Viacava P, Miccoli P, Torregrossa L, Basolo F, Pelizzo MR, Rugge M, Pennelli G, Gasparri G, Papotti M, Volante M, Vignali E, Saponaro F, and Marcocci C
- Abstract
Inactivating mutations of the CDC73 tumor suppressor gene have been reported in parathyroid carcinomas (PC), in association with the loss of nuclear expression of the encoded protein, parafibromin. The aim of this study was to further investigate the role of the CDC73 gene in PC and evaluate whether gene carrier status and/or the loss of parafibromin staining might have an effect on the outcome of the disease. We performed genetic and immunohistochemical studies in parathyroid tumor samples from 35 patients with sporadic PC. Nonsense or frameshift CDC73 mutations were detected in 13 samples suitable for DNA sequencing. Six of these mutations were germline. Loss of parafibromin expression was found in 17 samples. The presence of the CDC73 mutation as well as the loss of parafibromin predicted a high likelihood of subsequent recurrence and/or metastasis (92.3%, P=0.049 and 94.1%, P=0.0017 respectively), but only the latter was associated with a decreased overall 5- and 10-year survival rates (59%, P=0.107, and 23%, P=0.0026 respectively). The presence of both the CDC73 mutation and loss of parafibromin staining compared with their absence predicted a lower overall survival at 10- (18 vs 84%, P=0.016) but not at 5-year follow-up. In conclusion, loss of parafibromin staining, better than CDC73 mutation, predicts the clinical outcome and mortality rate. The added value of CDC73 mutational analysis is the possibility of identifying germline mutations, which will prompt the screening of other family members.
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- 2013
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24. Acute hyperparathyroidism: our experience with 36 cases.
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Gasparri G, Camandona M, Mullineris B, Raggio E, Vigna S, and Dei Poli M
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- Acute Disease, Diagnosis, Differential, Female, Humans, Hypercalcemia etiology, Hyperparathyroidism, Secondary surgery, Male, Middle Aged, Parathyroid Hormone blood, Parathyroidectomy, Retrospective Studies, Syndrome, Adenoma surgery, Hyperparathyroidism diagnosis, Hyperparathyroidism mortality, Hyperparathyroidism surgery, Hyperparathyroidism therapy, Parathyroid Neoplasms surgery
- Abstract
Objectives: Acute hypercalcemia is a serious condition and represents a physician-surgical emergency: the difficulty in setting a precise diagnosis is due to several possibilities that can cause the condition. It is our purpose to critically evaluate the most actual schemes of treatment and the conditions that could favour the appearance of a hypercalcemic acute crisis., Materials and Methods: A retrospective study was performed considering 1321 patients (638 primary HPT, 683 secondary or tertiary HPT) operated from 1975 to December 2002 for Primary, Secondary and Tertiary HPT., Results: It should be noticed that out of 638 cases of Primary HPT this syndrome was present in 35 patients (Ca higher than 15 mg/dl): if you compare these cases with the hyperparathyroid population with calcium less than 15 mg/dl it is possible to observe that a double adenoma or a carcinoma were more frequently found in acute HPT, as the cystic appearance of the lesion. The weight of the adenoma and the PTH assay are strictly correlated with the appearance of this syndrome. The mortality rate is also higher (2.8% to 0.1%) than in the hyperparathyroid patient who underwent parathyroidectomy without hypercalcemic crisis., Conclusion: These characteristics suggest that an early operation is mandatory in the patients in whom such a possibility could be expected, before serious involvement of the cardiovascular, renal or neuromuscular system. We can point out the rarity of this syndrome in Secondary and Tertiary HPT: just one case in Secondary out of 683 patients operated on from 1975 until December 2002.
- Published
- 2004
25. [Surgical treatment of secondary and tertiary hyperparathyroidism].
- Author
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Gasparri G, Camandona M, Mengozzi G, Mullineris B, Raggio E, and Vigna S
- Subjects
- Female, Humans, Hyperparathyroidism blood, Hyperparathyroidism classification, Male, Middle Aged, Parathyroid Hormone blood, Retrospective Studies, Hyperparathyroidism surgery
- Abstract
Aims: To determine whether, in secondary and tertiary hyperparathyroidism (HPT), quick parathyroid hormone (PTH) assay can be used to prevent persistent or recurrent HPT. Another point was to determine, considering the PTH decrease, the cut-off point at which the operation could be considered well performed., Methods: A retrospective study was performed evaluating all cases operated on since 1975 until 2002, 679 patients, and particularly the analysis of two groups of patients that underwent surgical treatment for secondary and tertiary HPT in the period 1995-2002. In the first group, (January 1995-October 1999) 207 (167 HPT II and 40 HPT III) neck explorations were performed without the aid of quick PTH assay; in the second group (November 1999-December 2002), 192 (153 HPT II and 39 HPT III) patients were operated on with blood samples for quick PTH., Results: In the first group the percentage of success for secondary HPT was 93.8 versus 96.2 of the second group and 91.7 versus 94.2 for tertiary HPT. In reoperations the percentage of success was 72.7 in the first group and 87.5 in the second one., Conclusions: There are no substantial differences in persistences or recurrences between subtotal or total parathyroidectomy (PTx) with autotransplantation (AT). The choice of the gland to be left in the neck or transplanted in the forearm and the modalities of doing so are very important, considering the macroscopical and histological aspects. Intraoperative PTH monitoring is a useful aid during the first cervical exploration for secondary and tertiary HPT to prevent the development of persistent or recurrent HPT. The cut-off point for secondary HPT is 70% (in difficult cases with more than 2 assays, 75%) and for tertiary HPT 50% and 70% respectively.
- Published
- 2003
26. Secondary and tertiary hyperparathyroidism: causes of recurrent disease after 446 parathyroidectomies.
- Author
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Gasparri G, Camandona M, Abbona GC, Papotti M, Jeantet A, Radice E, Mullineris B, and Dei Poli M
- Subjects
- Adult, Female, Humans, Immunohistochemistry, Male, Middle Aged, Parathyroid Glands transplantation, Recurrence, Retrospective Studies, Transplantation, Autologous, Treatment Outcome, Hyperparathyroidism, Secondary pathology, Hyperparathyroidism, Secondary surgery, Parathyroidectomy methods
- Abstract
Objective: To determine, in a series of patients with secondary and tertiary parathyroid hyperplasia, whether the type of parathyroidectomy (subtotal, total with autotransplantation, or total), the histologic pattern of the parathyroid tissue, or the proliferative index, as determined by Ki-67 analysis, could predispose patients to recurrent hyperparathyroidism., Summary Background Data: Recurrent hyperparathyroidism appears in 10--70% of the patients undergoing surgery for secondary or tertiary hyperparathyroidism. The incidence could be related to the type of operation (Rothmund) but also depends on the histologic pattern of the glands removed (Niederle)., Methods: The retrospective investigation was performed on 446 patients undergoing parathyroid surgery. They were also studied in relation to the possibility of renal transplantation. In this population, two homogeneous groups were subsequently identified (23 patients with clear signs of recurrence and 27 patients apparently cured); they were studied from the histologic and immunohistochemical point of view using antibody to Ki-67 antigen., Results: Subtotal parathyroidectomy, total parathyroidectomy with autotransplantation, and total parathyroidectomy produced similar results when considering the regression of osteodystrophy, pruritus, and ectopic calcification. As one could anticipate, total parathyroidectomy increased the incidence of hypoparathyroidism. The percentage of recurrence was 5% to 8% after subtotal parathyroidectomy, total parathyroidectomy with autotransplantation, and total parathyroidectomy, and only after incomplete parathyroidectomy did this percentage climb to 34.7%. In the recurrence group, the nodular form was more common and the proliferative fraction detected by Ki-67 was 1.9%; it was 0.81% in the control group., Conclusions: Because more radical procedures were not more effective, the authors favor a less radical procedure such as subtotal parathyroidectomy. Histologic patterns and proliferative fraction could be useful indices of a recurrence, and these patients should be watched closely after surgery.
- Published
- 2001
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