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10. BIODEGRADABLE POLYMER-BASED COMPOSITES FILLED WITH BIOCHAR FOR TUNABLE RELEASE OF CARVACROL

Author

Botta L., Lopresti F., Pernice G., Garofalo G., Gaglio R., Botta L., Lopresti F., Pernice G., Garofalo G., and Gaglio R.

Subjects
carvacrol, PBAT, biochar, bio-composite
Abstract

Bio-composites are commonly obtained by combining biodegradable polymers with fillers collected from natural resources. In this context, biochar (BC) is attracting high interest as filler for polymer-based composites due to its challenging properties, including ecosustainability. This study aimed to prepare and characterize bio-composites with antimicrobial properties evaluating the role of the filler in the release kinetics. In particular, BC as filler and carvacrol (CRV) as antimicrobial agent, were incorporated via melt-compounding in poly(butylene adipate-co-terephthalate) (PBAT) samples. The rheological, tensile, and antimicrobial properties of the obtained bio-composites were evaluated paying particular attention to the influence of BC concentration, i.e., 5, 10, and 20 wt%, on the investigated properties. Moreover, the influence of BC content on the release kinetics of carvacrol was studied and mathematically modeled to evaluate the release mechanism. The results showed that the presence of biochar modified the carvacrol release in comparison with the unfilled system thus allowing to tune the release kinetics.

Published
2022

11. Efficacy of a reduced pill burden on therapeutic adherence to calcineurin inhibitors in renal transplant recipients: an observational study

Author

Sabbatini M, Garofalo G, Borrelli S, Vitale S, Torino M, Capone D, Russo L, Pisani A, Carrano R, Gallo R, and Federico S

Subjects
Medicine (General), R5-920
Abstract

Massimo Sabbatini,1 Gianluca Garofalo,1 Silvio Borrelli,2 Sossio Vitale,1 Massimiliano Torino,1 Domenico Capone,3 Luigi Russo,3 Antonio Pisani,1 Rosa Carrano,1 Riccardo Gallo,1 Stefano Federico11Nephrology, Department of Public Health, University Federico II of Naples, 2Department of Nephrology, Second University of Naples, 3Department of Neurosciences, Unit of Clinical Pharmacology, University Federico II of Naples, Naples, ItalyPurpose: The aim of this study was to determine the prevalence of nonadherence in a cohort of renal transplant recipients (RTRs) and to evaluate prospectively whether more intense clinical surveillance and reduced pill number enhanced adherence.Patients and methods: The study was carried out in 310 stable RTRs in whom adherence, life satisfaction, and transplant care were evaluated by specific questionnaires (time 0). The patients under tacrolimus (TAC; bis in die [BID]) were then shifted to once-daily TAC (D-TAC) to reduce their pill burden (Shift group) and were followed up for 6 months to reevaluate the same parameters. Patients on cyclosporin or still on BID-TAC constituted a time-control group.Results: The prevalence of nonadherence was 23.5% and was associated with previous rejection episodes (P

Published
2014

12. Machine Learning Meets Data Modification: The Potential of Pre-processing for Privacy Enchancement

Author

Batina, L., Bäck, T., Buhan, I., Picek, S., Garofalo, G., Slokom, M., Preuveneers, D., Joosen, W., Larson, M., Batina, L., Bäck, T., Buhan, I., Picek, S., Garofalo, G., Slokom, M., Preuveneers, D., Joosen, W., and Larson, M.

Abstract

Item does not contain fulltext, We explore how data modification can enhance privacy by examining the connection between data modification and machine learning. Specifically, machine learning “meets” data modification in two ways. First, data modification can protect the data that is used to train machine learning models focusing it on the intended use and inhibiting unwanted inference. Second, machine learning can provide new ways of creating modified data. In this chapter, we discuss data modification approaches, applied during data pre-processing, that are suited for online data sharing scenarios. Specifically, we define two scenarios “User data sharing” and “Data set sharing” and describe the threat models associated with each scenario and related privacy threats. We then survey the landscape of privacy-enhancing data modification techniques that can be used to counter these threats. The picture that emerges is that data modification approaches hold promise to enhance privacy, and can be used alongside of conventional cryptographic approaches. We close with an outlook on future directions focusing on new types of data, the relationship among privacy, and the importance of taking an interdisciplinary approach to data modification for privacy enhancement.

Published
2022

14. Le piccole e medie imprese italiane nella riflessione di Francesco Parrillo e nel contesto dell’economia italiana del III millennio: un percorso di ricerca sul capitalismo italiano con una verifica empirica

Author

Garofalo, G, Guarini, G, Chiacchierini, C, GAROFALO,G, GUARINI, G, CHIACCHIERINI, C, Garofalo, G, Guarini, G, Chiacchierini, C, GAROFALO,G, GUARINI, G, and CHIACCHIERINI, C

Abstract

Partendo dall’esame di alcuni contributi di Francesco Parrillo, compresi in un arco temporale che va dal 1983 al 1999, sul tema delle PMI (anche nei suoi riflessi finanziari), l’articolo propone una attualizzazione di quella riflessione per interpretare la realtà del sistema produttivo italiano nella seconda decade del nuovo millennio. I temi emergenti sono legati alla vitalità delle medie imprese, alla nuova manifattura digitale, ad una maggiore attenzione per la diversificazione delle fonti di finanziamento. A fronte di questi spiragli, permangono alcuni nodi critici strutturali come le difficoltà della maggior parte delle imprese, segnate dalla ridotta dimensione, la loro sottocapitalizzazione, i modelli superati di governance, che, a livello macroeconomico, comportano bassi livelli di produttività. Al riguardo viene condotta un’analisi econometrica per testare l’ipotesi che una “soluzione” possa venire da reti d’impresa che collaborano su progetti mirati di innovazione (e/o internazionalizzazione)., Starting from an accurate selection of contributions written, in the 1983-1999 period, by Francesco Parrillo on SMEs (also in its financial implications), the paper proposes to contextualize its analysis in recent times, in order to interpret the modern nature of the Italian productive system. Emerging relevant topics arerelated to the dynamism of Medium-sized firms, the new digital manufacture, and to the diversification of funding sources. However, critical issues still remain, such as small dimension, undercapitalization, outdated governance, which imply low productivity levels. In this regard, we propose an econometric analysis to test the hypothesis that a “solution” can come from business networks with firms that collaborate on targeted innovation (and/or internationalization) projects.

Published
2020

15. Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey

Author

Nordio, M., Reboldi, G., Di Napoli, A., Quintaliani, G., Alberici, F., Postorino, M., Aucella, F., Messa, P., Brunori, G., Bosco, M., Malberti, F., Mandreoli, M., Mazzaferro, S., Movilli, E., Ravera, M., Salomone, M., Santoro, D., Postorinolimido, M. A., Bonomini, M., Stingone, A., Maccarone, M., Di Loreto, E., Stacchiotti, L., Malandra, R., Chiarella, S., D'Agostino, F., Fuiano, G., Nicodemo, L., Bonofiglio, R., Greco, S., Mallamaci, F., Barreca, E., Caserta, C., Bruzzese, V., Galati, D., Tramontana, D., Viscione, M., Chiuchiolo, L., Tuccillo, S., Sepe, M., Vitale, F., Ciriana, E., Martignetti, V., Caserta, D., Stizzo, A., Romano, A., Iulianiello, G., Cascone, E., Minicone, P., Chiricone, D., Delgado, G., Barbato, A., Celentano, S., Molfino, I., Coppola, S., Raiola, I., Abategiovanni, M., Borrelli, S., Margherita, C., Bruno, F., Ida, M., Aliperti, E., Potito, D., Cuomo, G., De Luca, M., Merola, M., Botta, C., Garofalo, G., Alinei, P., Paglionico, C., Roano, M., Vitale, S., Ierardi, R., Fimiani, V., Conte, G., Di Natale, G., Romano, M., Di Marino, V., Scafarto, A., Meccariello, S., Pecoraro, C., Di Stazio, E., Di Meglio, E., Cuomo, A., Maresca, B., Rotaia, E., Capasso, G., Auricchio, M., Pluvio, C., Maddalena, L., De Maio, A., Palladino, G., Buono, F., Gigliotti, G., Mancini, E., La Manna, G., Storari, A., Mosconi, G., Cappelli, G., Scarpioni, R., Gregorini, M., Rigotti, A., Mancini, W., Bianco, F., Boscutti, G., Amici, G., Tosto, M., Fini, R., Pace, G., Cioffi, A., Boccia, E., Di Lullo, L., Di Zazzo, G., Simonelli, R., Bondatti, F., Miglio, L., Rifici, N., Treglia, A., Muci, M., Baldinelli, G., Rizzi, E., Lonzi, M., De Cicco, C., Forte, F., De Paolis, P., Grandaliano, Giuseppe, Cuzziol, C., Torre, V. M., Sfregola, P., Rossi, V., Fabio, G., Flammini, A., Filippini, A., Onorato, L., Vendola, F., Di Daniela, N., Alfarone, C., Scabbia, L., Ferrazzano, M., Grotta, B. D., Gamberini, M., Fazzari, L., Mene, P., Morgia, A., Catucci, A., Palumbo, R., Puliti, M., Marinelli, R., Polito, P., Marrocco, F., Morabito, S., Rocca, R., Nazzaro, L., Lavini, R., Iamundo, V., Chiappini, M., Casarci, M., Morosetti, M., Hassan, S., Firmi, G., Galliani, M., Serraiocco, M., Feriozzi, S., Valentini, W., Sacco, P., Garibotto, G., Cappelli, V., Saffioti, C., Repetto, M., Rolla, D., Lorenz, M., Pedrini, L., Polonioli, D., Galli, E., Ruggenenti, P., Scolari, F., Bove, S., Costantino, E., Bracchi, M., Mangano, S., Depetri, G., La Milia, V., Farina, M., Zecchini, S., Savino, R., Melandri, M., Guastoni, C., Paparella, M., Gallieni, M., Minetti, E., Bisegna, S., Righetti, M., Badalamenti, S., Alberghini, E., Bertoli, S., Fabbrini, P., Albrizio, P., Rampino, T., Colturi, C., Rombola, G., Lucatello, A., Guerrini, E., Ranghino, A., Lenci, F., Fanciulli, E., Santarelli, S., Damiani, C., Garofalo, D., Sopranzi, F., Santoferrara, A., Di Luca, M., Galiotta, P., Brigante, M., Manganaro, M., Maffei, S., Berto, I., Besso, L., Viglino, G., Cusinato, S., Chiarinottichiappero, D. F., Tognarelli, G., Gianoglio, B., Forneris, G., Biancone, L., Savoldi, S., Vitale, C., Boero, R., Filiberti, O., Borzumati, M., Gesualdo, L., Lomonte, C., Gernone, G., Pallotta, G., Di Paolo, S., Vernaglione, L., Specchio, A., Stallone, G., Dell'Aquila, R., Sandri, G., Russo, F., Napoli, M., Marangi, A., Morrone, L., Di Stratis, C., Fresu, A., Cicu, F., Murtas, S., Manca, O., Pani, A., Pilloni, M., Pistis, R., Cadoni, M., Contu, B., Logias, F., Ivaldi, R., Fancello, S., Cossu, M., Lepori, G., Vittoria, S., Battiati, E., Arnone, M., Rome, M., Barbera, A., Granata, A., Collura, G., Dico, C. L., Pugliese, G., Di Natale, E., Rizzari, G., Cottone, L., Longo, N., Battaglia, G., Marcantoni, C., Giannetto, G., Tumino, G., Randazzo, F., Bellissimo, L., Faro, F. L., Grippaldi, F., Urso, S., Quattrone, G., Todaro, I., Vincenzo, D., Murgo, A., Masuzzo, M., Pisacane, A., Monardo, P., Pontorierro, M., Quari, C., Bauro, A., Chimenz, R. R., Alfio, D., Girasole, F., Cascio, A. L., Caviglia, A., Tornese, F., Sirna, F., Altieri, C., Cusumano, R., Saveriano, V., La Corte, A., Locascio, G., Rotolo, U., Musso, S., Risuglia, L., Blanco, G., Minardo, G., Castellino, S., Zappulla, Z., Randone, S., Di Francesca, M., Cassetti, C. C., Oddo, G., Buscaino, G., Mucaria, F., Barraco, V. I., Di Martino, A., Rallo, D., Dani, L., Campolo, G., Manescalchi, F., Biagini, M., Agate, M., Panichi, V., Casani, A., Traversari, L., Garosi, G., Tabbi, M., Selvi, A., Cencioni, L., Fagugli, R., Timio, F., Leveque, A., Manes, M., Mennella, G., Calo, L., Fiorini, F., Abaterusso, C., Calzavara, P., Meneghel, G., Bonesso, C., Gambaro, G., Gammaro, L., Rugiu, C., Ronco, C., Nordio M., Reboldi G., Di Napoli A., Quintaliani G., Alberici F., Postorino M., Aucella F., Messa P., Brunori G., Bosco M., Malberti F., Mandreoli M., Mazzaferro S., Movilli E., Ravera M., Salomone M., Santoro D., PostorinoLimido M.A., Bonomini M., Stingone A., Maccarone M., Di Loreto E., Stacchiotti L., Malandra R., Chiarella S., D'Agostino F., Fuiano G., Nicodemo L., Bonofiglio R., Greco S., Mallamaci F., Barreca E., Caserta C., Bruzzese V., Galati D., Tramontana D., Viscione M., Chiuchiolo L., Tuccillo S., Sepe M., Vitale F., Ciriana E., Martignetti V., Caserta D., Stizzo A., Romano A., Iulianiello G., Cascone E., Minicone P., Chiricone D., Delgado G., Barbato A., Celentano S., Molfino I., Coppola S., Raiola I., Abategiovanni M., Borrelli S., Margherita C., Bruno F., Ida M., Aliperti E., Potito D., Cuomo G., De Luca M., Merola M., Botta C., Garofalo G., Alinei P., Paglionico C., Roano M., Vitale S., Ierardi R., Fimiani V., Conte G., Di Natale G., Romano M., Di Marino V., Scafarto A., Meccariello S., Pecoraro C., Di Stazio E., Di Meglio E., Cuomo A., Maresca B., Rotaia E., Capasso G., Auricchio M., Pluvio C., Maddalena L., De Maio A., Palladino G., Buono F., Gigliotti G., Mancini E., La Manna G., Storari A., Mosconi G., Cappelli G., Scarpioni R., Gregorini M., Rigotti A., Mancini W., Bianco F., Boscutti G., Amici G., Tosto M., Fini R., Pace G., Cioffi A., Boccia E., Di Lullo L., Di Zazzo G., Simonelli R., Bondatti F., Miglio L., Rifici N., Treglia A., Muci M., Baldinelli G., Rizzi E., Lonzi M., De Cicco C., Forte F., De Paolis P., Grandaliano G., Cuzziol C., Torre V.M., Sfregola P., Rossi V., Fabio G., Flammini A., Filippini A., Onorato L., Vendola F., Di Daniela N., Alfarone C., Scabbia L., Ferrazzano M., Grotta B.D., Gamberini M., Fazzari L., Mene P., Morgia A., Catucci A., Palumbo R., Puliti M., Marinelli R., Polito P., Marrocco F., Morabito S., Rocca R., Nazzaro L., Lavini R., Iamundo V., Chiappini M., Casarci M., Morosetti M., Hassan S., Firmi G., Galliani M., Serraiocco M., Feriozzi S., Valentini W., Sacco P., Garibotto G., Cappelli V., Saffioti C., Repetto M., Rolla D., Lorenz M., Pedrini L., Polonioli D., Galli E., Ruggenenti P., Scolari F., Bove S., Costantino E., Bracchi M., Mangano S., Depetri G., La Milia V., Farina M., Zecchini S., Savino R., Melandri M., Guastoni C., Paparella M., Gallieni M., Minetti E., Bisegna S., Righetti M., Badalamenti S., Alberghini E., Bertoli S., Fabbrini P., Albrizio P., Rampino T., Colturi C., Rombola G., Lucatello A., Guerrini E., Ranghino A., Lenci F., Fanciulli E., Santarelli S., Damiani C., Garofalo D., Sopranzi F., Santoferrara A., Di Luca M., Galiotta P., Brigante M., Manganaro M., Maffei S., Berto I., Besso L., Viglino G., Cusinato S., ChiarinottiChiappero D.F., Tognarelli G., Gianoglio B., Forneris G., Biancone L., Savoldi S., Vitale C., Boero R., Filiberti O., Borzumati M., Gesualdo L., Lomonte C., Gernone G., Pallotta G., Di Paolo S., Vernaglione L., Specchio A., Stallone G., Dell'Aquila R., Sandri G., Russo F., Napoli M., Marangi A., Morrone L., Di Stratis C., Fresu A., Cicu F., Murtas S., Manca O., Pani A., Pilloni M., Pistis R., Cadoni M., Contu B., Logias F., Ivaldi R., Fancello S., Cossu M., Lepori G., Vittoria S., Battiati E., Arnone M., Rome M., Barbera A., Granata A., Collura G., Dico C.L., Pugliese G., Di Natale E., Rizzari G., Cottone L., Longo N., Battaglia G., Marcantoni C., Giannetto G., Tumino G., Randazzo F., Bellissimo L., Faro F.L., Grippaldi F., Urso S., Quattrone G., Todaro I., Vincenzo D., Murgo A., Masuzzo M., Pisacane A., Monardo P., Pontorierro M., Quari C., Bauro A., Chimenz R.R., Alfio D., Girasole F., Cascio A.L., Caviglia A., Tornese F., Sirna F., Altieri C., Cusumano R., Saveriano V., La Corte A., Locascio G., Rotolo U., Musso S., Risuglia L., Blanco G., Minardo G., Castellino S., Zappulla Z., Randone S., Di Francesca M., Cassetti C.C., Oddo G., Buscaino G., Mucaria F., Barraco V.I., Di Martino A., Rallo D., Dani L., Campolo G., Manescalchi F., Biagini M., Agate M., Panichi V., Casani A., Traversari L., Garosi G., Tabbi M., Selvi A., Cencioni L., Fagugli R., Timio F., Leveque A., Manes M., Mennella G., Calo L., Fiorini F., Abaterusso C., Calzavara P., Meneghel G., Bonesso C., Gambaro G., Gammaro L., Rugiu C., and Ronco C.

Subjects
Male, Contextual analysis, medicine.medical_treatment, Population, 030232 urology & nephrology, Recursive partitioning, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Classification tree, COVID-19, Renal replacement therapy, Risk Factors, Medical, Surveys and Questionnaires, Health care, medicine, Settore MED/14 - NEFROLOGIA, Humans, education, Pandemics, Societies, Medical, Female, Italy, Nephrology, education.field_of_study, business.industry, Multilevel model, Decision rule, Confidence interval, Original Article, Hemodialysis, business, Contextual analysi, Societies, Demography
Abstract

Background and aim: Over 80% (365/454) of the nation’s centers participated in the Italian Society of Nephrology COVID-19 Survey. Out of 60,441 surveyed patients, 1368 were infected as of April 23rd, 2020. However, center-specific proportions showed substantial heterogeneity. We therefore undertook new analyses to identify explanatory factors, contextual effects, and decision rules for infection containment. Methods: We investigated fixed factors and contextual effects by multilevel modeling. Classification and Regression Tree (CART) analysis was used to develop decision rules. Results: Increased positivity among hemodialysis patients was predicted by center location [incidence rate ratio (IRR) 1.34, 95% confidence interval (CI) 1.20–1.51], positive healthcare workers (IRR 1.09, 95% CI 1.02–1.17), test-all policy (IRR 5.94, 95% CI 3.36–10.45), and infected proportion in the general population (IRR 1.002, 95% CI 1.001–1.003) (all p < 0.01). Conversely, lockdown duration exerted a protective effect (IRR 0.95, 95% CI 0.94–0.98) (p < 0.01). The province-contextual effects accounted for 10% of the total variability. Predictive factors for peritoneal dialysis and transplant cases were center location and infected proportion in the general population. Using recursive partitioning, we identified decision thresholds at general population incidence ≥ 229 per 100,000 and at ≥ 3 positive healthcare workers. Conclusions: Beyond fixed risk factors, shared with the general population, the increased and heterogeneous proportion of positive patients is related to the center’s testing policy, the number of positive patients and healthcare workers, and to contextual effects at the province level. Nephrology centers may adopt simple decision rules to strengthen containment measures timely.

Published
2021

19. Identifying Persistent Hot Spot Areas of Undersized Fish and Crustaceans in Southern European Waters: Implication for Fishery Management Under the Discard Ban Regulation

Author

European Commission, Fundação para a Ciência e a Tecnologia (Portugal), Agencia Estatal de Investigación (España), Milisenda, Giacomo, Garofalo, G., Fiorentino, Fabio, Colloca, Francesco, Maynou, Francesc, Ligas, Alessandro, Musumeci, Claudia, Bentes, Luis, Gonçalves, Jorge M.S., Erzini, Karim, Russo, Tommaso, D'Andrea, Lorenzo, Vitale, Sergio, European Commission, Fundação para a Ciência e a Tecnologia (Portugal), Agencia Estatal de Investigación (España), Milisenda, Giacomo, Garofalo, G., Fiorentino, Fabio, Colloca, Francesco, Maynou, Francesc, Ligas, Alessandro, Musumeci, Claudia, Bentes, Luis, Gonçalves, Jorge M.S., Erzini, Karim, Russo, Tommaso, D'Andrea, Lorenzo, and Vitale, Sergio

Abstract

The recent establishment of the “landing obligation” under the reformed EU Common Fishery Policy has the twofold objective of reducing the excessive practice of discarding unwanted catch at sea and encouraging more selective and sustainable fisheries. Within this context, the awareness of the spatial distribution of potential unwanted catches is important for devising management measures aimed to decrease discards. This study analyzed the distribution of Hot Spot density areas of demersal fish and crustaceans below the Minimum Conservation Reference Size (MCRS) in four different southern European seas: continental Portuguese coast, Catalan Sea, South of Sicily, Liguria and northern Tyrrhenian Seas using both bottom trawl survey data and information on the spatial distribution of commercial fisheries. Critical areas for discarding were identified as zones where the highest densities of individuals below MCRS were consistently recorded throughout a series of years. Results clearly showed a patchy distribution of undersized individuals in each investigated area, highlighting the overlap between high density patches of both discards and fishing effort. The present findings provide a relevant knowledge for supporting the application of spatial-based management actions, such as the designation of Fisheries Restricted Areas (FRAs), in order to minimize the by-catch of undersized specimens and improve the sustainability of demersal fisheries

Published
2021

20. Utility of ultrasound-guided fine needle aspiration cytology in assessing malignancy in head and neck pathology

Author

Petrone, G., Rossi, E. D., Gallus, R., Petrelli, L., Marrone, S., Rizzo, D., Piras, A., Garofalo, G., Rindi, G., Galli, J., Paludetti, G., Bussu, F., Petrone G., Petrelli L., Rizzo D. (ORCID:0000-0003-1809-5901), Rindi G. (ORCID:0000-0003-2996-4404), Galli J. (ORCID:0000-0001-6353-6249), Paludetti G. (ORCID:0000-0003-2480-1243), Bussu F. (ORCID:0000-0001-6261-2772), Petrone, G., Rossi, E. D., Gallus, R., Petrelli, L., Marrone, S., Rizzo, D., Piras, A., Garofalo, G., Rindi, G., Galli, J., Paludetti, G., Bussu, F., Petrone G., Petrelli L., Rizzo D. (ORCID:0000-0003-1809-5901), Rindi G. (ORCID:0000-0003-2996-4404), Galli J. (ORCID:0000-0001-6353-6249), Paludetti G. (ORCID:0000-0003-2480-1243), and Bussu F. (ORCID:0000-0001-6261-2772)

Abstract

Objective: Fine needle aspiration cytology (FNAC) is a well-established diagnostic procedure for head and neck masses not clearly originating from mucosal or cutaneous surfaces. We analysed head and neck masses evaluated over a 2-year period, to assess the reliability of FNAC for the evaluation of malignancy. Methods: We enrolled all patients undergoing FNAC, from April 2013 to July 2015, in a single service of a large Italian university hospital. Relevant clinical data and ultrasonographic parameters of the lesions were recorded. We performed both conventional and thin-prep smears. Clinical presentation, ultrasonographic features and final cytology diagnoses were analysed and correlated with histology. Results: The series included 301 lesions in 285 patients, with a single (94.4%) or two (5.6%) lesions. Only eight samples were considered non-diagnostic/inadequate (2.6%). Among the cases, 139 FNAC (46.1%) underwent surgery. Cytological-histological correspondence was found in 89% of the cases. Concerning malignancy, we documented less than 4% false positives and less than 2.5% false negatives, with 92.7% sensitivity and 94.6% specificity. Conclusion: FNAC diagnosis can be highly specific. Most importantly, it is highly reliable in assessing malignancy, thus defining the priority and guiding the management procedures.

Published
2021

24. OP03.02: Artificial intelligence applied to ultrasound diagnosis of pelvic gynecological tumours: a systematic scoping review and meta‐analysis.

Author

Garofalo, G., Geysels, A., Timmerman, S., Barreñada, L., De Moor, B., Timmerman, D., Froyman, W., and Van Calster, B.

Subjects
*ARTIFICIAL intelligence, *DEEP learning, *MACHINE learning, *DATABASES, *ADNEXAL diseases, PELVIC tumors
Abstract

This article discusses the use of artificial intelligence (AI) in the diagnosis of pelvic gynecological tumors using ultrasound imaging. The authors conducted a systematic scoping review and meta-analysis of published studies on this topic. They found that while AI has the potential to enhance diagnostic accuracy and efficiency, current AI models for US diagnosis of gynecological tumors have methodological shortcomings. The authors also noted that AI models for diagnosing adnexal malignancy did not outperform the ADNEX model, a logistic regression model based on US measurements. [Extracted from the article]

Published
2024
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25. OC05.03: *Deep learning‐enabled ovarian cancer detection with ADNEX‐AI: a prospective, multicentre study.

Author

Geysels, A., Garofalo, G., Timmerman, S., Ceusters, J., Fischerová, D., Testa, A.C., Moro, F., Buonomo, F., Valentin, L., Sladkevicius, P., Van Holsbeke, C., Kudla, M.J., Czekierdowski, A., Epstein, E., Groszmann, Y., Blaschko, M., De Moor, B., Van Calster, B., Timmerman, D., and Froyman, W.

Subjects
*CONVOLUTIONAL neural networks, *OVARIAN tumors, *DEEP learning, *RECEIVER operating characteristic curves, *EARLY detection of cancer
Abstract

This article discusses a study that introduces a deep learning-based framework called ADNEX-AI for the automated detection of ovarian cancer using ultrasound scans. The study compares the performance of ADNEX-AI with traditional clinical practice in diagnosing ovarian cancer. The results show that ADNEX-AI achieves a high level of accuracy in distinguishing between benign and malignant ovarian tumors. However, the study suggests that the difference in performance between ADNEX-AI and traditional methods may be due to the clinician's ability to examine the tumor from different angles. Overall, ADNEX-AI demonstrates comparable performance to traditional methods when considering the constraints of tumor visibility. [Extracted from the article]

Published
2024
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26. Bycatch of Demersal Elasmobranchii in the Strait of Sicily.

Author

Falsone, F., Calabrò, M., Fiorentino, F., Gancitano, V., Garofalo, G., Geraci, M.L., Massi, D., Sardo, G., Scannella, D., and Vitale, S.

Subjects
DREDGING (Fisheries), FISHERY management, LIFE history theory, GROUNDFISHES, RAYS (Fishes), SHARKS
Abstract

Falsone, F.; Calabrò, M.; Fiorentino, F.; Gancitano, V.; Garofalo, G.; Geraci, M.L.; Massi, D.; Sardo, G.; Scannella, D., and Vitale, S., 2024. Bycatch of demersal Elasmobranchii in the Strait of Sicily In: Phillips, M.R.; Al-Naemi, S., and Duarte, C.M. (eds.), Coastlines under Global Change: Proceedings from the International Coastal Symposium (ICS) 2024 (Doha, Qatar). Journal of Coastal Research, Special Issue No. 113, pp. 941-945. Charlotte (North Carolina), ISSN 0749-0208. Fishing activities greatly threaten Elasmobranchii due to their vulnerable life-history traits. Elasmobranchii have been a common bycatch in the Mediterranean bottom trawling fleets since the 1970s, and most of them are listed as threatened owing to overexploitation by fisheries. The study aims to identify and estimate the number of rays and sharks caught by bottom trawling operating in the North sector of the Strait of Sicily, Central Mediterranean Sea. This area represents one of the most important fishing grounds for demersal species, exploited mainly by trawl fisheries where an important component of commercial and discarded bycatch comprises cartilaginous fishes. An assessment of the impact of trawl fishery on sharks and skates by examining bycatch recorded between 2009 and 2021 is provided. Zero-Inflated Negative Binomial (ZINB) Models were used to standardize catch data and predict the relative bycatch rates. The findings reveal that 13 rays and 8 sharks were caught during the monitoring period. Raja clavata and Raja miraletus are the most frequently captured rays, constituting around 13% and 10% of the total monitored hauls. Among sharks, Scyliorhinus canicula was the most frequently captured species, found in about 17% of the total monitored hauls, followed by Squalus blainville with approximately 8%. According to the International Union for Conservation of Nature Red List for the Mediterranean, among these 21 species, four are reported as Data Deficient, five Least Concern, six Near Threatened, three Vulnerable, four Endangered and one Critically Endangered. ZIBN outcomes indicate decreasing trends of CPUE of Rays while increasing trends are observed for Sharks. Information reported in this study is paramount to support management and conservation measures for these vulnerable species whose adoption is at an early stage in the Strait of Sicily. [ABSTRACT FROM AUTHOR]

Published
2024
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30. SIMWESTMED - Case Study #4 'Strait of Sicily - Malta' (R23)

Author

Farella, G., Borg, M., Bassan, N., Campostrini, P., Coletta, M., Contarini, L., Di Carlo, D., Fadini, A., Fabbri, F., Formosa, S., Garofalo, G., Gissi, E., Gristina, M., Hili, O., Innocenti, A., Maccarrone, V., Manea, E., Maragno, D., Menegon, S., Morelli, M., Musco, F., Quattrocchi, F., Sarretta, A., Varone, E., Vella, A., Venier, C., and Barbanti, A

Subjects
Western Mediterranean, Strait of Sicily, SIMWESTMED, transboundary, Maritime Spatial Planning, MSP, Case study
Abstract

Component: C 1.3 Support for Member States' implementation of Maritime Spatial Planning Sub‐component: C 1.3.6. Establish Case Studies on Approaches to MSP Implementation Case Study #4 Strait of Sicily (Italy-Malta) The SIMWESTMED case study for Malta is focused on the Malta - Sicily marine waters, bordering the south of Sicily and the north of the Maltese Islands. The study area (9420 km2) features portions of internal, territorial and international waters, continental shelf areas, Malta’s Contiguous Zone and Malta’s Fisheries Management Conservation Zone. After a thorough refinement of information on legal/planning status, environmental conditions and uses and acquisition of fine scale spatial data, available approaches and toolsets (http://data.adriplan.eu/tools4msp/) were used to identify MSP issues for the area, conflicts among uses and their cumulative effects on the marine environment, proper analysis of land-sea interactions, and elaborate recommendations for transboundary MSP. Results and stakeholders engagement were used for the proposal of integrated sectoral measures, with the identification of possible management objectives, plan proposals and recommendations., This report/document was produced as part of the SIMWESTMED Project (Grant Agreement N0. EASME/EMFF/2015/1.2.1.3/02/SI2.742101). PROJECT: Supporting Implementation of Maritime Spatial Planning in the Western Mediterranean region (SIMWESTMED) Competition for maritime space – for renewable energy equipment, aquaculture and other uses – has highlighted the need to manage our waters more coherently. Maritime spatial planning (MSP) works across borders and sectors to ensure human activities at sea take place in an efficient, safe and sustainable way. That is why the European Parliament and the Council have adopted a legislation to create a common framework for maritime spatial planning in Europe. The Directive 2014/89/EU of the European Parliament and of the Council of 23 July 2014 (said Maritime Spatial Planning Directive) establishes a framework in order to reduce conflicts between sectors and create synergies between different activities, to encourage investment – by creating predictability, transparency and clearer rules, to increase cross-border cooperation – between EU countries to develop energy grids, shipping lanes, pipelines, submarine cables and other activities, but also to develop coherent networks of protected areas, and to protect the environment – through early identification of impact and opportunities for multiple use of space. The SIMWESTMED project (Supporting Implementation of Maritime Spatial Planning in the Western Mediterranean region) is an EU/DG Mare co-funded cross-border project. It was launched on 1st of January 2017 and involves Spain, France, Italy and Malta, while these countries had just designated their Competent Authorities and transposed the Maritime Spatial Planning (MSP) Directive. SIMWESTMED aims to support the implementation of the MSP Directive in the waters of Spain, France, Italy and Malta, as well as to establish cross-border cooperation mechanisms between these Member States, to contribute to the coherence of their marine spatial plans to be established by 2021. The action ran until 31st of December 2018 and was based on a partnership of public bodies of the countries and two international organisations. It was composed of CEDEX, IEO, AFB, CEREMA, Shom, CORILA and its affiliated entities IUAV and CNR-ISMAR, MIT, IMELS, PA, CPMR, UNEP-MAP and its affiliated entity UNEP-MAP/PAP-RAC. Shom acted as coordinator. The objectives of the SIMWESTMED project were addressed through a variety of activities and desktop or case studies. They are dedicated to identifying the methodology steps, and explore the challenges and opportunities of the MSP implementation in the Western Mediterranean area, including thus related to transboundary issues (Ecosystem based approach, marine policies, Barcelona Convention, Land Sea Interactions, geographical scale of the plans, data interoperability, tools to support MSP). The project led to a multiplicity of outputs including overviews of MSP relevant information related to the countries and on more focus areas, to a number of interviews and meetings where stakeholder views were collected to feed the reasoning, and to guidelines and good practices to be shared at a national and transnational level with marine stakeholders, scientists as well as planners, administrations and authorities. In addition, SIMWESTMED permitted a lot of progression internally in the countries and regarding transboundary cooperation. It led to establish and develop new dialogues and to connect the technical or scientific actors, the stakeholders, the administrations of the countries of a same sea basin, and the administrations within the countries, including the representative of Regions. It allowed to better understand Maritime Spatial Planning mechanisms, to share knowledge and as such reached to build capacities, which is of importance as there is such a need in the Mediterranean area compared to more Northern countries. The project also permitted to address topics which have never been addressed before. The involvement of some countries in SIMWESTMED and in the EU-DG Mare "brother" projects SUPREME, SIMNORAT and SIMCelt was useful for them to develop a global vision with their neighbours through the East and West side of the Mediterranean and in the Atlantic sea basin. At the end of this exercise, it is stated the need of pursuing the work and dialogue in particular through common tools, but at this stage, the SIMWESTMED has constituted a common knowledge and background. Disclaimer: The contents and conclusions of this report, including the maps and figures, do not imply the expression of any opinion or endorsement of the participating partners concerning the legal status of any country, territory, area, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The depiction and use of boundaries, geographic names and related data shown on maps included in this report are not warranted to be error free nor do they imply official endorsement or acceptance by any of the participating partners. This report is a working document and may rely on data from sources external to the SIMWESTMED project Consortium and, in addition to this, it may contain some information gaps. Neither the European Commission or Executive Agency for Small and Medium-sized Enterprises nor UN Environment/MAP Barcelona Convention Secretariat may be held responsible for any use that may be made of the information contained in this report.

Published
2019
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31. Intersectional Politics on Domestic Workers' Rights. The Cases of Ecuador and Colombia

Author

Evans, E, Lépinard, E, Cherubini, D, Garofalo, G, Marchetti, S, Garofalo, GG, Evans, E, Lépinard, E, Cherubini, D, Garofalo, G, Marchetti, S, and Garofalo, GG

Abstract

The chapter looks at domestic workers’ movements as a telling case of collective action developed by multiply-marginalised social groups, in particular migrant, low-class, racialised, and rural women employed in the sector. The present study focuses on Ecuador and Colombia, exploring the ways in which organisations in both contexts used intersectionality differently, in various aspects of their mobilisation process, in the period between 2010 and 2018. Interestingly, activists in Ecuador appear to develop a complex discourse that articulates the role that gender and class, in addition to race, play in the inequalities that weigh on domestic workers, and yet when they lobby their government to ratify the ILO ‘Convention No. 189 on decent work for domestic workers,’ they privilege alliances based on class and the promotion of labour rights. On the contrary, in Colombia, activists are able to use their intersectional identities, as Afro-Colombian women domestic workers, to bring into the public sphere a discourse in which gender, race, and class are always present, and they do so by originally articulating a new frame rooted in a feminist analysis of the ‘care economy.’

Published
2020

32. Marine spatial closures as a supplementary tool to reduce discards in bottom trawl fisheries: Examples from southern European waters

Author

European Commission, Agencia Estatal de Investigación (España), Despoti, Smaragda, Milisenda, Giacomo, Ligas, Alessandro, Bentes, Luis, Maynou, Francesc, Vitale, Sergio, Garofalo, G., Sbrana, Mario, Erzini, Karim, Tserpes, George, Tsagarakis, K., Maina, Iridia, Pyrounaki, Maria-Myrto, Papadopoulou, Nadia, Machias, A., Colloca, Francesco, Fiorentino, Fabio, Stergiou, K.I., Giannoulaki, Marianna, European Commission, Agencia Estatal de Investigación (España), Despoti, Smaragda, Milisenda, Giacomo, Ligas, Alessandro, Bentes, Luis, Maynou, Francesc, Vitale, Sergio, Garofalo, G., Sbrana, Mario, Erzini, Karim, Tserpes, George, Tsagarakis, K., Maina, Iridia, Pyrounaki, Maria-Myrto, Papadopoulou, Nadia, Machias, A., Colloca, Francesco, Fiorentino, Fabio, Stergiou, K.I., and Giannoulaki, Marianna

Abstract

Discards is an important issue in fisheries around the world. The spatial management of discards has attracted interest as a potential tool for minimizing the unwanted catch. The aim of the present work was to identify areas with high quantities of bottom trawl discarded catch regarding species subjected to MCRS, in six areas of southern European waters (southern Portuguese waters, Catalan Sea, Ligurian and northern Tyrrhenian Seas, Strait of Sicily, eastern Ionian Sea, and Aegean Sea). Analyses were based on two types of data: (a) the undersized catch of species subjected to MCRS from bottom trawl surveys and (b) the actual discarded catch (including undersized and non-undersized individuals) of species subjected to MCRS from commercial bottom trawling. Geostatistical analysis techniques were applied to the first type of data and Generalized Additive Models using environmental variables were applied to the second one. Subsequently, areas that persistently presented high quantities of discarded catch (i.e., “iDC grounds”) or undersized catch (i.e., “iUC grounds”) were identified and mapped. The “iDC grounds”/“iUC grounds” were located either over the slope or within the continental shelf and over marine plateaus, largely depending on the main target species of each fishery. Next, the overlap of “iDC grounds”/“iUC grounds” with the existing Fisheries Restricted Areas (FRAs) and the proposed Marine Protected Areas (MPAs) was estimated aiming to explore how spatial closures could contribute to the reduction of bottom trawl discarded catch/undersized catch. Certain spatial closures were more effective in the Central Mediterranean and others to the Eastern Mediterranean. The overlapping of existing FRAs with “iDC grounds”/“iUC grounds” did not exceed 24 % in any study area, whereas proposed MPAs, like the CIESM Marine Peace Parks, reached up to 90 % for the same study area

Published
2020

35. Spatio-temporal composition of discard associated with the deep water rose shrimp fisheries (Parapenaeus longirostris, Lucas 1846) in the south-central Mediterranean Sea

Author

Milisenda, G., Vitale, S., Massi, D., Enea, M., Gancitano, V., Giusto, G. B., Badalucco, C., Gristina, M., Garofalo, G., Fiorentino, F., Milisenda, G, Vitale, S, Massi, D, Enea, M, Gancitano, V, Giusto, GB, Badalucco, C, Gristina, M, Garofalo, G, and Fiorentino, F

Subjects
Settore BIO/07 - Ecologia, Environmental Engineering, Bycatch, Parapenaeus longirostri, Self-sampling program, Discard ban, Settore SECS-S/05 - Statistica Sociale, Aquatic Science, Bottom trawling, Oceanography, Ecology, Evolution, Behavior and Systematic, Parapenaeus longirostris
Abstract

Discarding in fisheries is the fraction of the total catch brought on board and returned to the sea dead or alive for legal or economic reasons. The reduction of discard is one of the main objectives of the European Common Fishery Policy. This study aimed to improve the current knowledge of the discard associated with the deep-water rose shrimp (DPS) fisheries in the south-central Mediterranean Sea. We analyzed data collected from January 2009 to December 2013. Multivariate data analysis and generalized additive models (GAMs) were used to assess the spatio-temporal composition of the discard (which represented 36% of the total catch) and factors influencing its distribution. Multiple analysis of variance highlighted the significant effect of depth factor on discard assemblage. Moreover, in general, bony fish were the most discarded organisms (23.5%), while cartilaginous fish, crustaceans and other invertebrates represented approximately 13% of the total catch. GAMs showed that the fraction of discard in the catch presented significant variation regarding the years, depth and fishing ground. Although the negative trend in discard suggested that the DPS fisheries are moving towards a more sustainable exploitation, the discard fraction in some areas/assemblages remains high. Our results showed that most of the discard was due to species that had a minimum legal size (Hake, DPS, Trachurus spp.), and consequently would be subjected to the European discard ban. In order to improve the fisheries management, specific measures aimed to minimize the unwanted catches of undersized species need to be implemented.

Published
2017
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39. Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network

Author

Agodi, A., Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, Patrizia, Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, M. R., Alliani, C., Amatucci, M. R., Antoci, M., Antonelli, Massimo, Astuto, M., Arnoldo, L., Arru, B., Baccari, G., Barbadoro, P., Barbara, A., Barilaro, Cynthia, Battaglia, P., Bellocchi, Paolo, Bernasconi, M. O., Bianco, Assunta, Bissolo, E., Bocchi, A., Bruno, A., Brusaferro, M., Buccheri, M., Campanella, F., Canino, R., Cannistra, A., Carini, S. A., Catalano, S., Castellani, P., Castiglione, G., Coniglio, S., Consolante, C., Conte, Caterina, Contrisciani, R., Corallini, R., Crollari, P., Damiani, Gianfranco, Denaro, C., De Remigis, S., Diana, F., Di Bartolo, R., Di Benedetto, A., Di Fabio, G., Di Falco, C., Digeronimo, V., Di Gregorio, P., Distefano, R., Egitto, G., Falciani, E., Farruggia, P., Fenaroli, S., Ferlazzo, G., Garofalo, G., Girardis, M., Giovanelli, Laura, Giubbini, Gabriele, Graceffa, A., Guadagna, A., Gregu, G., Ingala, F., Innocenzi, L., La Camera, G., La Rosa, M. C., Lesa, L., Longhitano, A. M., Luppino, G., Maida, C. M., Manta, G., Marino, G., Masia, M. D., Maviglia, Riccardo, Mazzetti, M., Maugeri, A., Megna, M. T., Mella, L. M., Milazzo, M., Milia, M., Minari, C., Minerva, M., Mordacci, M., Murgia, P., Oliveri, P., Olori, M. P., Pagliarulo, R., Palermo, R., Pandiani, I., Pappalardo, F., Papetti, C., Partenza, A., Pascu, D., Pasculli, M., Pavia, M., Pavone, M. L., Pellegrino, Maria Gabriella, Pelligra, F., Pillon, D., Pintaudi, S., Pitzoi, L., Pinto, A., Piotti, P., Pupo, S., Quattrocchi, R., Righi, E., Rigo, A., Romeo, A., Rosa, Enrico, Rutigliano, S., Sarchi, P., Scimonello, G., Seminerio, A., Stefanini, P., Sticca, G., Taddei, S., Tessari, L., Tetamo, R., Ticca, M., Tribastoni, S., Vallorani, S., Venturoni, F., Vitagliano, E., Vitali, P., Zappone, Assunta, Zei, E., Zeoli, M. P., Laurenti P. (ORCID:0000-0002-8532-0593), Antonelli M. (ORCID:0000-0003-3007-1670), Barilaro C. (ORCID:0000-0002-6576-8921), Bellocchi P., Bianco A., Conte C., Damiani G. (ORCID:0000-0003-3028-6188), Giovanelli L. (ORCID:0009-0007-8931-6253), Giubbini G., Maviglia R., Pellegrino M. G., Rosa E., Zappone A., Agodi, A., Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, Patrizia, Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, M. R., Alliani, C., Amatucci, M. R., Antoci, M., Antonelli, Massimo, Astuto, M., Arnoldo, L., Arru, B., Baccari, G., Barbadoro, P., Barbara, A., Barilaro, Cynthia, Battaglia, P., Bellocchi, Paolo, Bernasconi, M. O., Bianco, Assunta, Bissolo, E., Bocchi, A., Bruno, A., Brusaferro, M., Buccheri, M., Campanella, F., Canino, R., Cannistra, A., Carini, S. A., Catalano, S., Castellani, P., Castiglione, G., Coniglio, S., Consolante, C., Conte, Caterina, Contrisciani, R., Corallini, R., Crollari, P., Damiani, Gianfranco, Denaro, C., De Remigis, S., Diana, F., Di Bartolo, R., Di Benedetto, A., Di Fabio, G., Di Falco, C., Digeronimo, V., Di Gregorio, P., Distefano, R., Egitto, G., Falciani, E., Farruggia, P., Fenaroli, S., Ferlazzo, G., Garofalo, G., Girardis, M., Giovanelli, Laura, Giubbini, Gabriele, Graceffa, A., Guadagna, A., Gregu, G., Ingala, F., Innocenzi, L., La Camera, G., La Rosa, M. C., Lesa, L., Longhitano, A. M., Luppino, G., Maida, C. M., Manta, G., Marino, G., Masia, M. D., Maviglia, Riccardo, Mazzetti, M., Maugeri, A., Megna, M. T., Mella, L. M., Milazzo, M., Milia, M., Minari, C., Minerva, M., Mordacci, M., Murgia, P., Oliveri, P., Olori, M. P., Pagliarulo, R., Palermo, R., Pandiani, I., Pappalardo, F., Papetti, C., Partenza, A., Pascu, D., Pasculli, M., Pavia, M., Pavone, M. L., Pellegrino, Maria Gabriella, Pelligra, F., Pillon, D., Pintaudi, S., Pitzoi, L., Pinto, A., Piotti, P., Pupo, S., Quattrocchi, R., Righi, E., Rigo, A., Romeo, A., Rosa, Enrico, Rutigliano, S., Sarchi, P., Scimonello, G., Seminerio, A., Stefanini, P., Sticca, G., Taddei, S., Tessari, L., Tetamo, R., Ticca, M., Tribastoni, S., Vallorani, S., Venturoni, F., Vitagliano, E., Vitali, P., Zappone, Assunta, Zei, E., Zeoli, M. P., Laurenti P. (ORCID:0000-0002-8532-0593), Antonelli M. (ORCID:0000-0003-3007-1670), Barilaro C. (ORCID:0000-0002-6576-8921), Bellocchi P., Bianco A., Conte C., Damiani G. (ORCID:0000-0003-3028-6188), Giovanelli L. (ORCID:0009-0007-8931-6253), Giubbini G., Maviglia R., Pellegrino M. G., Rosa E., and Zappone A.

Abstract

Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.

Published
2018

41. Demersal cephalopod communities in the Mediterranean – a large scale analysis

Author

Keller, S. (Stefanie), Hidalgo, M. (Manuel), Álvarez-Berastegui, D. (Diego), Bitetto, I. (Isabella), Casciaro, L. (Loredana), Cuccu, D. (Danila), Esteban-Acón, A. (Antonio), Garofalo, G. (Germana), González-Aguilar, M. (María), Guijarro, B. (Beatriz), Josephides, M. (Marios), Jadaud, A. (Angélique), Lefkaditou, E. (Eugenia), Maiorano, P. (Porzia), Manfredi, C. (Chiara), Marceta, B. (Bojan), Micallef, R. (Reno), Peristeraki, P. (Panagiota), Relini, G. (Giulio), Sartor, P. (Paolo), Spedicato, M.T. (Maria Teresa), Tserpes, G. (George), and Quetglas, A. (Antoni)

Subjects
Cephalopods, Community analysis, Environmental gradients, Mediterranean, Bottom trawl surveys, MEDITS
Abstract

Cephalopod assemblages at the scale of the entire Mediterranean Sea were analysed using information from 2 decades of standardized scientific bottom trawl surveys. Western and eastern assemblages (6 yr of data) were compared using a combined approach of multivariate ordination techniques and non-linear regressions. These methods enabled us to distinguish assemblages and simultaneously analyse the influence of geographic, bathymetric and environmental (sea surface temperature and chlorophyll a concentration) gradients on observed community patterns. Despite few differences in species composition between sub-basins, the relative contribution of species differed. Bathymetry was the primary structural driver for the cephalopod communities of both basins, and contributed to 3 assemblages (shallow water, upper slope and middle slope). Winter temperature influenced community assemblages more strongly in the western than in the eastern basin, in contrast to a small but consistent winter productivity influence on community assemblages in both basins. Thus, the environmental parameters analysed did not cause an immediate change in cephalopod assemblages, but rather an effect lagged by several months. Differences in the relative importance of environmental drivers show that different processes operate in the 2 basins. These results demonstrate similarities and differences between Mediterranean basins regarding important cephalopod functional groups. This information should help integrative ecosystem management approaches currently used in fisheries and conservation management.

Published
2017

42. The prognostic importance of chronic end-stage diseases in geriatric patients admitted to 163 Italian ICUs

Author

Poole, D., Finazzi, S., Nattino, G., Radrizzani, D., Gristina, G., Malacarne, P., Livigni, S., Bertolini, G., Sorgato, C., Mannoni, R., Agnelli, V., Chiani, C., Lanza, G., Venturini, E., Gianni, M., Olivieri, M. C., Guerriero, B., Della Mora, E., Palmer, M., Blasetti, A., Coletta, R., Covani Frigieri, F., Guarducci, M. D., Caracciolo, A., Lain, G., Bernard, M., DE Blasio, E., Zanni, V., Marchesi, G., Madeira, S. M., Spagarino, E., Potalivo, A., Mengoli, F., Parrini, V., Sagliaschi, U., Prandini, A., Rosano, A., Natalini, G., Piccioni, G., Schiavuzzi, M., Bronzini, N., Piva, S., Besozzi, A., Napoleone, A., Patrignani, L., Pisu, M., Mancosu, S., Chiarello, M., Pastorini, S., Bassi, G., Negro, G., Orsini, I., Marifoglou, D., Pota, V., Pegoraro, M., Sucre, M. J., DI Masi, P., Castiglione, G., Morello, G., Garofalo, G., Caroleo, S., Visconti, M. G., Gamberini, E., Mastroianni, A., Liccardi, M. M., Anelati, D., Martinelli, S., Bonato, A., Adorni, A., Colombo, D., Dal Cero, P., Crema, L., Petrucci, N., Beck, E., Alleva, S., Giuntini, R., DA Re, D., Casalini, P., Fabi, M. C., Galeotti, E., Bagalini, G., Bellonzi, A., Zoppellari, R., Lamborghini, S., Pera, L., Doni, L., Bonizzoli, M., Librenti, M., Barattini, M., Mangani, V., Terzitta, M., Guagliardi, C., Bruzzone, C., Arditi, E., Cerana, M., Tavola, M., Falini, S., Vespignani, M. G., Salvi, G., Ramello, P. L., Molesi, A., Ceradelli, M., Buonanno, R., Righini, E., DI Cocco, A., DI Martino, R., Cinque, E., Bonfiglio, M., Ciceri, R., Colombo, L., Nardini, M., Rossi, G., Boccalatte-Rosa, D. L., Babini, M., Zompanti, V., Negri, G., Antonini, B., Baratta, A., Zuccaro, F., Rossi, M., Pedeferri, M., Bellin, M., Sicignano, A., Pezzi, A., Leggieri, C., Fontana, G., Faraldi, L., Cigada, M. G., Magenta, P., Colombo, R., Colombo, S., Gonzi, S., Pizzali, M., Girardis, M., Piccinini, P., Bignone, P., Padovan, L., Bianchin, A., Caria, F. C., Randellini, R., Roticiani, V., Grassi, M., Belluomo Anello, C., Decristofaro, M., Postiglione, M., Giacomello, S., Olivieri, C., Vaccari, C., Dal Ferro, M., Messina, M., Belgiorno, N., Odetto, L., Pasetti, G. S., Balicco, B., Pizzaballa, M. L., Muraro, L., Pignataro, A., Guadagna, A., Fabbri, P. G., Tetamo, R., Bottazzi, A., Mediani, T. S., Gorietti, A., Breschi, C., Ciani, A., Segalini, P., Codeluppi, V., Berruto, F., Pastorelli, M., Comite, C., Pelati, E., Bertolini, R., Lefons, U., DI Pasquale, D. A., Mannolini, G., Vlassich, F., Becarelli, S., Garelli, A., Salsi, P., Rossi, S., Facondini, F., Alampi, D., Cingolani, E., Molino, F. M., Nardi, G., Casula, M., DE Blasi, R. A., Vulcano, G. A., Azzolini, M., Bernasconi, M. O., Bellato, V., Calicchio, G., Righetti, F., Turati, M., Dei Poli, M., Zaro, G., Brizio, E., Coaloa, M., Falzetti, G., Mamprin, F., Liverani, C. M., Clementi, S., Bonucci, P., Varesio, V., Pannacci, R., Fiore, G., Gallo, M., Torta, M., Selvaggi, P., Bert, P. P., Segala, V., Pettazzi, G., Bensi, M., Bocchi, A., Cima, M., Morbelli, M., Peta, M., DI Stella, R., Maggiolo, C., Lembo, R., Pero, A., Marafon, S., Carnevale, L., Vanzino, R., Vecchiarelli, P., and Marino, G.

Subjects
Male, medicine.medical_specialty, Cirrhosis, Disease, Severity of Illness Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Patient Admission, Postoperative Complications, law, Internal medicine, 80 and over, aged, critical care, prognosis, Medicine, Dementia, Humans, Hospital Mortality, Elective surgery, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Critical care, Prognosis, Female, Intensive Care Units, Italy, Chronic Disease, 030208 emergency & critical care medicine, Odds ratio, medicine.disease, Comorbidity, Intensive care unit, Anesthesiology and Pain Medicine, 030228 respiratory system, Cohort, business
Abstract

BACKGROUND The number of elderly patients undergoing major surgical interventions and then needing admission to intensive care unit (ICU) grows steadily. We investigated this issue in a cohort of 232,278 patients admitted in five years (2011-2015) to 163 Italian general ICUs. METHODS Surgical patients older than 75 registered in the GiViTI MargheritaPROSAFE project were analyzed. The impact on hospital mortality of important chronic conditions (severe COPD, NYHA class IV, dementia, end-stage renal disease, cirrhosis with portal hypertension) was investigated with two prognostic models developed yearly on patients staying in the ICU less or more than 24 hours. RESULTS 44,551 elderly patients (19.2%) underwent emergency (47.3%) or elective surgery (52.7%). At least one severe comorbidity was present in 14.6% of them, yielding a higher hospital mortality (32.4%, vs. 21.1% without severe comorbidity). In the models for patients staying in the ICU 24 hours or more, cirrhosis, NYHA class IV, and severe COPD were constant independent predictors of death (adjusted odds ratios [ORs] range 1.67-1.97, 1.54-1.91, and 1.34-1.50, respectively), while dementia was statistically significant in four out of five models (adjusted ORs 1.23-1.28). End-stage renal disease, instead, never resulted to be an independent prognostic factor. For patients staying in the ICU less than 24 hours, chronic comorbidities were only occasionally independent predictors of death. CONCLUSIONS Our study confirms that elderly surgical patients represent a relevant part of all ICUs admissions. About one of seven bear at least one severe chronic comorbidity, that, excluding end-stage renal disease, are all strong independent predictors of hospital death.

Published
2017

43. Demersal cephalopod communities in the Mediterranean: a large-scale analysis

Author

Keller, S, primary, Hidalgo, M, additional, Álvarez-Berastegui, D, additional, Bitetto, I, additional, Casciaro, L, additional, Cuccu, D, additional, Esteban, A, additional, Garofalo, G, additional, Gonzalez, M, additional, Guijarro, B, additional, Josephides, M, additional, Jadaud, A, additional, Lefkaditou, E, additional, Maiorano, P, additional, Manfredi, C, additional, Marceta, B, additional, Micallef, R, additional, Peristeraki, P, additional, Relini, G, additional, Sartor, P, additional, Spedicato, MT, additional, Tserpes, G, additional, and Quetglas, A, additional

Published
2017
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44. P2.17-002 Pulmonary and Mediastinal Paragangliomas: Rare Endothoracic Malignancies with Challenging Diagnosis and Treatment

Author

De Palma, A., primary, Lorusso, M., additional, Di Gennaro, F., additional, Pizzuto, O., additional, Garofalo, G., additional, Fiorella, A., additional, Maiolino, E., additional, Nex, G., additional, Schiavone, M., additional, Gentile, A., additional, Lastilla, G., additional, Resta, L., additional, and Loizzi, M., additional

Published
2017
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45. Predictive distribution models of European hake in the south-central Mediterranean Sea

Author

Garofalo, G., primary, Fezzani, S., additional, Gargano, F., additional, Milisenda, G., additional, Ben Abdallah, O., additional, Ben Hadj Hamida, N., additional, Jarboui, O., additional, Chemmam-Abdelkader, B., additional, Khoufi, W., additional, Micallef, R., additional, Mifsud, R., additional, Gancitano, S., additional, Rizzo, P., additional, Zgozi, S., additional, Ceriola, L., additional, Arneri, E., additional, and Fiorentino, F., additional

Published
2017
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47. Mapping the potential locations of European hake (Merluccius merluccius) nurseries in the Italian waters

Author

Murenu, M., Cau, A., Colloca, Francesco, Sartor, P., Fiorentino, F., Garofalo, G., Piccinetti, C., Manfredi, C., D’Onghia, G., Carlucci, R., Donnaloia, L., Lembo, P., Murenu M., Cau A., Colloca F., Sartor P., Fiorentino F., Garofalo G., Piccinetti C., Manfredi C., D'Onghia G., Carlucci R., Donnaiola L., and Lembo P.

Subjects
nursery areas, MERLUCCIUS MERLUCCIUS, GIS, kriging, Mediterranean Sea, Merluccius merluccius, spatial analysis, persistence, nursery area, Mediterranean sea, KRIGING, spatial analysi
Abstract

A geostatistical approach was used to pinpoint the main nursery areas of demersal resources and define their persistence by means of direct estimation of fish densities. The European hake (Merluccius merluccius Linnaeus, 1758), one of the most important demersal resources inhabiting the whole Mediterranean from 30 metres (m) to almost 1000 m depth, was used as a case study to locate their recruits and check their stability using geo-spatial methods and common criteria. Data were collected during trawl surveys carried out in the late-spring and autumn from 1994 to 2006 in seven geographical sub-areas (GSAs) including Italian waters in the Western and Central Mediterranean. Indicator kriging was applied to locate the sites where number of recruits exceeded, at a given probability, a conditioned threshold value. The temporal persistence of high-density patches of recruits was then evaluated by means of an index of spatial persistence. Hake recruits showed patchy distribution with several denser areas showing a high temporal persistence. The main nursery areas were identified in the Central Adriatic Sea (GSA17), northern Tyrrhenian-Ligurian seas (GSA 9) and Sardinia (GSA 11). Important nurseries occurred also in the Strait of Sicily (GSA 16), South Adriatic Sea (GSA18) and North Ionian Sea (GSA19)

Published
2010

48. NEPTUNEA CONTRARIA (LINNAEUS, 1771) AND BUCCINUM UNDATUM LINNAEUS, 1758 (GASTROPODA, BUCCINIDAE) THANATOCOENOSIS IN THE STRAIT OF SICILY

Author

Massi D., Titone A., Mancuso M., Garofalo G., Gancitano V., Badalucco C., Gristina M., and Fiorentino F.

Subjects
Neptunea contraria, Strait of Sicily, thanatocoenosis, Buccinum undatum, biodiversity
Abstract

The analysis of 973 benthic samples from the trawlable bottoms of the Strait of Sicily allowed to identify a thanatocoenosis characterized by the fossil gastropods Neptunea contraria and Buccinum undatum in a restricted area of the incoherent bottoms of the canyon on the western shoulder of the Adventure Bank. This finding extends southernmost the known distribution area of these fossil species. Benthic community living on thanatocoenosis showed a higher biodiversity than those found in areas without dead shells.

Published
2015

49. MARINE LITTER ON TRAWLABLE BOTTOMS OF THE STRAIT OF SICILY

Author

Fiorentino F., Gancitano V., Giusto G.B., Massi D., Sinacori G., Titone A., Vinci A., and Garofalo G.

Subjects
Strait of Sicily, marine litter, trawl surveys
Abstract

Quantitative data on marine litter were collected during the MEDITS survey carried out in the Strait of Sicily in 2013. A total of 619 items (66 No./km2) were collected, being Plastic the most common category. A comparison with estimates of marine litter occurrence carried out in 1994, allowed to observe a general increase of pollution by solid waste on the trawlable grounds of the Strait of Sicily.

Published
2015

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