9 results on '"Garncarz, M."'
Search Results
2. Impact of selected individual dog traits on echocardiographic parameters obtained in 1-dimensional (M-mode) and 2-dimensional (2D) imaging.
- Author
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Szpinda O, Parzeniecka-Jaworska M, Jank M, Garncarz M, and Czopowicz M
- Subjects
- Aging, Animals, Electrocardiography methods, Female, Male, Body Weight, Dogs physiology, Electrocardiography veterinary
- Abstract
The popularity and availability of echocardiography in veterinary practice for companion animals have substantially increased in recent years. The results obtained during the procedure are compared to reference values established for the general dog population or to standards developed for a specific dog breed. The aim of this study was to determine whether individual dog traits, such as body weight, chest structure, and level of physical activity and performance, affect the reference values for echocardiographic parameters. Published reference values for echocardiographic examination parameters for 32 dog breeds were analyzed and the relationship between individual echocardiographic parameters and body weight, chest structure, and level of physical activity and performance was then statistically analyzed. It was found that echocardiographic parameters are affected by the dog's weight and physical activity. There was no significant relationship between heart size and chest structure. The great variety of dog breeds means that echocardiographic findings should be individually interpreted rather than establishing reference ranges for each breed in population studies. This will allow for a more accurate interpretation of the results obtained in the echocardiographic examination and consequently lead to earlier diagnosis of changes in myocardial morphology., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)
- Published
- 2021
3. Oscillometric and Doppler arterial blood pressure measurement in conscious goats.
- Author
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Szaluś-Jordanow O, Czopowicz M, Świerk A, Szpinda O, Garncarz M, Mickiewicz M, Moroz A, Bagnicka E, and Kaba J
- Subjects
- Animals, Blood Pressure Determination instrumentation, Blood Pressure Determination methods, Female, Heart Rate, Oscillometry instrumentation, Oscillometry methods, Ultrasonography, Doppler instrumentation, Blood Pressure physiology, Blood Pressure Determination veterinary, Goats physiology, Oscillometry veterinary, Sphygmomanometers veterinary, Ultrasonography, Doppler veterinary
- Abstract
The objective of this study was to characterize arterial blood pressure (BP) measurements obtained by using 2 indirect methods, oscillometry and Doppler ultrasonic sphygmomanometry, in conscious goats. Agreement between systolic BP yielded by these 2 methods was then assessed. Sixty female dairy goats aged from 1.5 to 11.8 y (median: 5.5 y) were examined in a standing position with a cuff placed on the tail. All goats had a severe arthritic form of caprine arthritis-encephalitis. Three to 5 repeated measurements of each BP type were averaged for each goat and considered as a final measurement. With oscillometry, systolic blood pressure (O-SBP), diastolic blood pressure, and mean blood pressure, as well as heart rate (HR) were measured, while only systolic blood pressure was measured with Doppler (D-SBP). The O-SBP did not correlate with D-SBP [correlation coefficient (r) = 0.24, P = 0.067]; the mean difference (± standard deviation) was 24.5 ± 26.3 mmHg and limits of agreement were from -27.2 mmHg [95% confidence interval (CI): -39.0, -15.4 mmHg] to 76.1 mmHg (95% CI: 64.3, 87.9 mmHg). No significant linear correlation was found between any BPs and HR ( r: -0.10 to 0.22) or age ( r: -0.26 to 0.07) of the goats. The study showed that, while BP could be measured in conscious goats using both oscillometry and Doppler ultrasonic sphygmomanometry, the results obtained were so inconsistent that these methods could not be used interchangeably.
- Published
- 2018
4. Comparison of oscillometric, Doppler and invasive blood pressure measurement in anesthetized goats.
- Author
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Szaluś-Jordanow O, Czopowicz M, Moroz A, Mickiewicz M, Garncarz M, Bagnicka E, Frymus T, and Kaba J
- Subjects
- Anesthetics pharmacology, Animals, Arterial Pressure, Female, Goats, Ketamine pharmacology, Male, Xylazine pharmacology, Blood Pressure Determination methods, Oscillometry, Ultrasonography, Doppler
- Abstract
Arterial blood pressure (BP) can be measured directly using an invasive intra-arterial method. This method is considered a gold standard, however it is potentially hazardous and requires expensive equipment and professional skills. Therefore, two non-invasive methods-Doppler ultrasonic sphygmomanometry and oscillometry-have been introduced in veterinary medicine. Their accuracy has so far been reliably evaluated in various animal species, however only one study included a small group of goats. Therefore, we carried out a large-scale study which aimed to evaluate agreement between the two non-invasive methods and invasive intra-arterial BP measurement in anesthetized goats at various age. The study included 122 goats of two Polish local breeds (Polish White Improved and Polish Fawn Improved): 67 adult females, 35 adult males, and 20 two-month-old female kids. Goats were anesthetized with the intravenous mixture of xylazine and ketamine. BP was measured simultaneously with the three methods in each goat with 7 measurements on average taken. The study showed that according to the criteria of the American College of Veterinary Internal Medicine (ACVIM) oscillometric method yielded BP measurements sufficiently consistent with invasive intra-arterial method in anesthetized adult goats- 95% of oscillometric BP measurements were expected to differ from invasive BP measurements by at most ±20-25 mmHg. The agreement was worse in goat kids-oscillometry significantly overestimated invasive BP measurements, which resulted in highly asymmetrical 95% limits of agreement. Doppler systolic BP very poorly conformed to invasive systolic BP both in adult goats and in kids and all the ACVIM criteria were violated. Concluding, oscillometry, but not Doppler ultrasonic sphygmomanometry, may be regarded as an alternative to invasive BP measurement in large-scale scientific studies involving adult goats, however, individual oscillometric BP measurements should be treated with caution as estimated 95% limits of agreement were wide., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2018
- Full Text
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5. Mitral Regurgitation in Dachshund Dogs without Heart Murmurs.
- Author
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Garncarz M, Parzeniecka-Jaworska M, Hulanicka M, Jank M, Szaluś-Jordanow O, and Kurek A
- Abstract
Introduction: Older small breed dogs are considered at risk for heart failure secondary to chronic mitral valve disease. However, few data are available on the onset of this disease in such dogs. This study was performed to determine if auscultation alone can be used to eliminate clinically relevant mitral valve regurgitation seen in echocardiography in Dachshund dogs., Material and Methods: Clinical and echocardiographic data were obtained from 107 dogs without heart murmurs., Results: The study revealed that 63.6% of the dogs had mitral regurgitation. Numbers increased with age and a larger percentage of male Dachshunds were affected than female Dachshunds. Mitral valve prolapse and thickening were mild, and the regurgitant area inextensive in most dogs., Conclusions: The study shows that mitral valve regurgitation is prevalent (63.6%) in Dachshunds without heart murmurs. Typical lesions often become apparent during echocardiographic examinations in dogs under 5 years of age., Competing Interests: Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.
- Published
- 2017
- Full Text
- View/download PDF
6. Intracardiac tuberculomas caused by Mycobacterium tuberculosis in a dog.
- Author
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Szaluś-Jordanow O, Augustynowicz-Kopeć E, Czopowicz M, Olkowski A, Łobaczewski A, Rzewuska M, Sapierzyński R, Wiatr E, Garncarz M, and Frymus T
- Subjects
- Animals, Dogs, Heart Diseases diagnostic imaging, Heart Diseases microbiology, Male, Radiography, Thoracic veterinary, Tuberculoma diagnostic imaging, Tuberculoma microbiology, Tuberculosis diagnostic imaging, Tuberculosis microbiology, Heart Diseases veterinary, Mycobacterium tuberculosis, Tuberculoma veterinary, Tuberculosis veterinary
- Abstract
Background: This paper presents an unusual form of disseminated Mycobacterium tuberculosis infection in a dog. The infection lasted at least one year and its main gross lesions were massive cardiac tuberculomas. To the best of our knowledge, this is the first report of heart tuberculomas in a dog., Case Presentation: A 9-year-old mixed-breed male dog weighing 10 kg was referred to the clinic for cardiological evaluation before general anesthesia. The echocardiography revealed a lump of about 20 mm in diameter in the area of the left atrium. Almost one year later the same dog was presented again in severe clinical state (fever, anorexia, weight loss, depression, cough, dyspnea, lymphadenomegaly, vomiting, recent episodes of fainting). Due to progression of the disease and poor effects of treatment the owner decided to euthanize the dog. Most prominent lesions observed during autopsy were diffuse pneumonia, fibrinous pericarditis and epicarditis as well as large, yellow, semisolid masses of caseous necrosis in the left and right atrium (30 mm and 15 mm in diameter, respectively). From both pulmonary and cardiac lesions M. tuberculosis was isolated on Lowenstein-Jensen slants and in Bactec Mycobacteria Growth Indicator Tube 960 liquid media, and confirmed by BD ProbeTec ET Direct Detection Assay and spoligotyping., Conclusion: Companion animals may occasionally suffer from tuberculosis but majority of cases probably remain misdiagnosed or undetected. Typically tuberculosis in dogs affects lungs and their regional lymph nodes. Even in humans tuberculomas are rare manifestation of mycobacterial infection, mostly seen in the central nervous system. Atypical location of main tuberculous lesions may account for lack of correct ante mortem diagnosis in this case.
- Published
- 2016
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7. Plasma miRNAs as potential biomarkers of chronic degenerative valvular disease in Dachshunds.
- Author
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Hulanicka M, Garncarz M, Parzeniecka-Jaworska M, and Jank M
- Subjects
- Animals, Biomarkers, Chronic Disease, Dog Diseases pathology, Dogs, Female, Heart Valve Diseases blood, Heart Valve Diseases diagnosis, Male, Dog Diseases blood, Heart Valve Diseases veterinary, MicroRNAs blood
- Abstract
Background: Endocardiosis is the most common heart disease in Dachshunds and is therefore an important cause of cardiac morbidity and death. In recent years we have observed an increasing interest in the development of new genetic and genomic markers of heart disease. The discovery of miRNAs circulating in biofluids such as plasma or serum aroused researchers' interest in using them as potential biomarkers. In the present study we analysed the expression of 9 miRNAs described in literature as being involved in cardiovascular pathology in the plasma of dogs suffering from endocardiosis., Results: Expression analysis using the Real-time PCR method revealed that two out of nine miRNAs were significantly downregulated: the expression of miR-30b differed between ACVIM stage B and stage A (control) dogs; the expression of mi-133b differed ACVIM stage C and stage A dogs. 5 miRNAs (miR-125, miR-126, miR-21, miR-29b and miR-30b) showed a trend of downregulation in the ACVIM C group. Levels of miR-423 were the same in healthy and diseased dogs. Expression of miR-208a and 208b was not detected., Conclusions: miR-30b could be a potential biomarker of ACVIM stage B heart failure in Dachshunds with endocardiosis and miR-133b could be a potential biomarker of ACVIM stage C. The lack of expression or lack of significant changes in expression in 7 miRNAs which are potential biomarkers of heart diseases in humans proves that findings from human medicine are not always directly reflected in veterinary medicine.
- Published
- 2014
- Full Text
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8. The transcriptomic profile of peripheral blood nuclear cells in dogs with heart failure.
- Author
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Hulanicka M, Garncarz M, Parzeniecka-Jaworska M, and Jank M
- Subjects
- Animals, Dog Diseases metabolism, Dogs, Female, Gene Expression Profiling, Gene Expression Regulation, Male, Signal Transduction, Blood Cells metabolism, Dog Diseases genetics, Heart Failure veterinary, Transcriptome
- Abstract
Background: In recent years advances have been made in the investigative methods of molecular background of canine heart disease. Studies have been conducted to identify specific genes which, when pathologically expressed, could lead to the dysfunction of the canine heart or are correlated with heart failure. For this purpose genome wide microarray experiments on tissues from failing hearts have been performed. In the presented study a whole genome microarray analysis was used for the first time to describe the transcription profile of peripheral blood nuclear cells in dogs with heart failure. Dogs with recognized heart disease were classified according the ISACHC (International Small Animal Cardiac Health Council) classification scheme as class 1 (asymptomatic)--13 dogs, class 2 (mild to moderate heart failure)--13 dogs and class 3 (severe heart failure)--12 dogs. The control group consisted of 14 healthy dogs. The clinical picture of the animals included: animal history, clinical examination, echocardiographic examination and where applicable electrocardiographic and radiographic examinations., Results: In the present study we identified four sets of differentially expressed genes, namely heart-failure-specific genes and ISACHC1-specific genes, ISACHC2-sepcific genes and ISACHC-3 specific genes. The most important set consisted of genes differentially expressed in all dogs with heart failure, despite the ISACHC stage. We identified 71 heart-failure-specific genes which were involved in two statistically significant receptor signalling pathways, namely angiotensinR - > CREB/ELK-SRF/TP53 signalling and ephrinR - > actin signalling. The number of ISACHC1-specific genes was 83; ISACHC2-specific genes--1247 and ISACHC3-specific--200., Conclusions: The transcriptomic profile of peripheral blood nuclear cells in dogs with heart failure seems to reflect the presence of clinical signs of the disease in patients based on the observation that the largest number of differentially expressed genes was identified in ISACHC 2 group of patients. This group consists of dogs just starting to show clinical signs of heart failure. A set of genes was also found to have changed expression in all dogs with heart failure, despite the stage of the disease.
- Published
- 2014
- Full Text
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9. A retrospective study of clinical signs and epidemiology of chronic valve disease in a group of 207 Dachshunds in Poland.
- Author
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Garncarz M, Parzeniecka-Jaworska M, Jank M, and Łój M
- Subjects
- Animals, Chronic Disease, Dog Diseases epidemiology, Dogs, Female, Heart Valve Diseases epidemiology, Heart Valve Diseases pathology, Male, Poland, Retrospective Studies, Dog Diseases pathology, Heart Valve Diseases veterinary
- Abstract
Background: Chronic mitral valve disease is frequently seen in the Dachshund. Dachshunds (n=207) made up 11.73% of the dogs admitted to the Cardiology Service at the Small Animal Clinic, Warsaw University of Life Sciences, Poland (first visits only)., Results: Of these, 35 dogs had no clinically detectable heart disease while 172 had chronic valve disease with the mitral valve affected most often (130 dogs), both mitral and tricuspid valves infrequently (39 dogs) and rarely the tricuspid valve (3 dogs). Males were affected more frequently than females and the average age of dogs with chronic valve disease was 11.9 years for females and 11.3 years for males. A majority of the diseased Dachshunds were classified as ISACHC 2 (79), followed by ISACHC 1 (60). Most frequent clinical signs noted by owners included coughing, exercise intolerance, dyspnea and tachypnea. Heart murmurs were generally louder with increased disease severity; however there were 20 dogs in the ISACHC 1 group with no audible heart murmurs. The most frequent electrocardiographic abnormalities included an increased P wave and QRS complex duration, increased R wave amplitude and tachycardia. With increased disease severity, echocardiography revealed an increase in heart size. A higher ISACHC class was related to increased heart size (based on echocardiography) and increased percentage of patients exhibiting enlargement of both left atrium and left ventricle (based on radiography)., Conclusions: The Dachshund is often affected by chronic mitral valvular disease with a late onset of associated clinical signs and few cardiac complications.
- Published
- 2013
- Full Text
- View/download PDF
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