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1. The 25in25 initiative: A novel transformative project to reduce mortality due to heart failure by 25% in the next 25 years.

Author

Savage, Henry Oluwasefunmi, McBeath, Kyle, Hogan, Janine, MacKay‐Thomas, Lynn, Anderson, Lisa, Smith, Andy, Bateman, Joanne, Brooks, Poppy, Bayes‐Genis, Antoni, Vest, Amanda, Teerlink, John, Rosano, Giuseppe, and Gardner, Roy S.

Subjects
BRAIN natriuretic factor, SODIUM-glucose cotransporter 2 inhibitors, ANGIOTENSIN-receptor blockers, MEDICAL personnel, PATIENT participation, INTERPROFESSIONAL education
Published
2024
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2. "Real‐world" performance of the Confirm Rx™ SharpSense AF detection algorithm: UK Confirm Rx study.

Author

Gala, Andre Briosa e, Pope, Michael T. B., Leo, Milena, Sharp, Alexander J., Banerjee, Abhirup, Field, Duncan, Thomas, Honey, Balasubramaniam, Richard, Hunter, Ross, Gardner, Roy S., Wilson, David, Gallagher, Mark M., Ormerod, Julian, Paisey, John, Curzen, Nick, and Betts, Timothy R.

Subjects
ATRIAL fibrillation diagnosis, PREDICTIVE tests, DISEASE duration, SEX distribution, AMBULATORY electrocardiography, RETROSPECTIVE studies, HOSPITALS, DESCRIPTIVE statistics, ARRHYTHMIA, RESEARCH, MEDICAL records, ACQUISITION of data, IMPLANTABLE cardioverter-defibrillators, PATIENT monitoring, TACHYCARDIA, ALGORITHMS, CARDIAC surgery
Abstract

Introduction: The novel Confirm Rx™ implantable cardiac monitor (ICM) with SharpSense™ technology incorporates a new P‐wave discriminator designed to improve AF detection. This study aimed to evaluate the diagnostic performance of the Confirm Rx™ ICM in detecting AF episodes of varying durations. Methods: We conducted a multicenter retrospective analysis of consecutive patients implanted with a Confirm Rx™ ICM (v1.2) across nine UK hospitals, all with documented AF lasting at least 6 min. Electrocardiograms (ECGs) were manually adjudicated by cardiologists. To account for intra‐ and inter‐reviewer variability, a random sample of 10% of ECGs underwent additional review. Disagreements were resolved by a third reviewer. Diagnostic performance was determined by calculating the gross and patient‐averaged positive predictive value (PPV) for AF episodes of different duration. The source of false positive (FP) detection was also categorized. Results: Overall, 16,230 individual ECGs from 232 patients were included. The median AF episode duration was 14 min. R‐wave amplitude remained stable during follow‐up (0.52 ± 0.27 mV [initial] vs. 0.54 ± 0.29 mV [end of follow‐up], p =.10). The gross and patient‐averaged PPV were 75.0% and 67.0%, respectively. Diagnostic performance (gross) increased with progressively longer AF episodes: 88.0% for ≥1 h, 97.3% for 6 h, and 100% for 24 h. The main source of FP during tachycardia was T‐wave oversensing (54.2%), while in non‐tachycardic episodes it was predominantly ectopy (71.2%). The AF burden precision was excellent (93.3%). Conclusion: The Confirm Rx™ ICM diagnostic performance was modest for all AF episodes (75%), with accuracy increasing for longer AF episodes. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Measuring congestion with a non‐invasive monitoring device in heart failure and haemodialysis: CONGEST‐HF

Author

Curtain, James P., primary, Talebi, Atefeh, additional, McIntosh, Alasdair, additional, McConnachie, Alex, additional, O'Donnell, Joanne, additional, Welsh, Paul, additional, Osmanska, Joanna, additional, Lee, Matthew M.Y., additional, Sonecki, Piotr, additional, Akl, Tony, additional, Seo, Joohyun, additional, Gopinathan, Venugopal, additional, Hurwitz, Jed, additional, Thiagarajan, Srikanth, additional, Pettit, Stephen, additional, Kalra, Paul R., additional, Patel, Rajan K., additional, Mark, Patrick B., additional, Lang, Ninian N., additional, McMurray, John J.V., additional, Petrie, Mark C., additional, Gardner, Roy S., additional, and Jhund, Pardeep S., additional

Published
2024
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4. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Boehm, Michael, Burri, Haran, Butler, Javed, Celutkiene, Jelena, Chioncel, Ovidiu, Cleland, John G. F., Crespo-Leiro, Maria Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S. P., Lyon, Alexander R., McMurray, John J. V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Francesco Piepoli, Massimo, Price, Susanna, Rosano, Giuseppe M. C., Ruschitzka, Frank, Skibelund, Anne Kathrine, de Boer, Rudolf A., Schulze, P. Christian, Arbelo, Elena, Bartunek, Jozef, Bauersachs, Johann, Borger, Michael A., Buccheri, Sergio, Cerbai, Elisabetta, Donal, Erwan, Edelmann, Frank, Faerber, Gloria, Heidecker, Bettina, Ibanez, Borja, James, Stefan, Kober, Lars, Koskinas, Konstantinos C., Masip, Josep, McEvoy, John William, Mentz, Robert, Mihaylova, Borislava, Moller, Jacob Eifer, Mullens, Wilfried, Neubeck, Lis, Nielsen, Jens Cosedis, Pasquet, Agnes A., Ponikowski, Piotr, Prescott, Eva, Rakisheva, Amina, Rocca, Bianca, Rossello, Xavier, Sade, Leyla Elif, Schaubroeck, Hannah, Tessitore, Elena, Tokmakova, Mariya, van der Meer, Peter, Van Gelder, Isabelle C., Van Heetvelde, Mattias, Vrints, Christiaan, Wilhelm, Matthias, Witkowski, Adam, Zeppenfeld, Katja, McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Boehm, Michael, Burri, Haran, Butler, Javed, Celutkiene, Jelena, Chioncel, Ovidiu, Cleland, John G. F., Crespo-Leiro, Maria Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S. P., Lyon, Alexander R., McMurray, John J. V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Francesco Piepoli, Massimo, Price, Susanna, Rosano, Giuseppe M. C., Ruschitzka, Frank, Skibelund, Anne Kathrine, de Boer, Rudolf A., Schulze, P. Christian, Arbelo, Elena, Bartunek, Jozef, Bauersachs, Johann, Borger, Michael A., Buccheri, Sergio, Cerbai, Elisabetta, Donal, Erwan, Edelmann, Frank, Faerber, Gloria, Heidecker, Bettina, Ibanez, Borja, James, Stefan, Kober, Lars, Koskinas, Konstantinos C., Masip, Josep, McEvoy, John William, Mentz, Robert, Mihaylova, Borislava, Moller, Jacob Eifer, Mullens, Wilfried, Neubeck, Lis, Nielsen, Jens Cosedis, Pasquet, Agnes A., Ponikowski, Piotr, Prescott, Eva, Rakisheva, Amina, Rocca, Bianca, Rossello, Xavier, Sade, Leyla Elif, Schaubroeck, Hannah, Tessitore, Elena, Tokmakova, Mariya, van der Meer, Peter, Van Gelder, Isabelle C., Van Heetvelde, Mattias, Vrints, Christiaan, Wilhelm, Matthias, Witkowski, Adam, and Zeppenfeld, Katja

Abstract

Document Reviewers: Rudolf A. de Boer (CPG Review Co-ordinator) (Netherlands), P. Christian Schulze (CPG Review Co-ordinator) (Germany), Elena Arbelo (Spain), Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger (Germany), Sergio Buccheri (Sweden), Elisabetta Cerbai (Italy), Erwan Donal (France), Frank Edelmann (Germany), Gloria Farber (Germany), Bettina Heidecker (Germany), Borja Ibanez (Spain), Stefan James (Sweden), Lars Kober (Denmark), Konstantinos C. Koskinas (Switzerland), Josep Masip (Spain), John William McEvoy (Ireland), Robert Mentz (United States of America), Borislava Mihaylova (United Kingdom), Jacob Eifer Moller (Denmark), Wilfried Mullens (Belgium), Lis Neubeck (United Kingdom), Jens Cosedis Nielsen (Denmark), Agnes A. Pasquet (Belgium), Piotr Ponikowski (Poland), Eva Prescott (Denmark), Amina Rakisheva (Kazakhstan), Bianca Rocca (Italy), Xavier Rossello (Spain), Leyla Elif Sade (United States of America/Turkiye), Hannah Schaubroeck (Belgium), Elena Tessitore (Switzerland), Mariya Tokmakova (Bulgaria), Peter van der Meer (Netherlands), Isabelle C. Van Gelder (Netherlands), Mattias Van Heetvelde (Belgium), Christiaan Vrints (Belgium), Matthias Wilhelm (Switzerland), Adam Witkowski (Poland), and Katja Zeppenfeld (Netherlands)All experts involved in the development of this Focused Update have submitted declarations of interest. These have been compiled in a report and simultaneously published in a supplementary document to the Focused Update. The report is also available on the ESC websiteSee the European Heart Journal online for supplementary documents that include evidence tables.

Published
2024
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5. “Real‐world” performance of the Confirm Rx™ SharpSense AFdetection algorithm: UKConfirm Rx study

Author

Gala, Andre Briosa e, Pope, Michael T. B., Leo, Milena, Sharp, Alexander J., Banerjee, Abhirup, Field, Duncan, Thomas, Honey, Balasubramaniam, Richard, Hunter, Ross, Gardner, Roy S., Wilson, David, Gallagher, Mark M., Ormerod, Julian, Paisey, John, Curzen, Nick, and Betts, Timothy R.

Abstract

The novel Confirm Rx™ implantable cardiac monitor (ICM) with SharpSense™ technology incorporates a new P‐wave discriminator designed to improve AF detection. This study aimed to evaluate the diagnostic performance of the Confirm Rx™ ICM in detecting AF episodes of varying durations. We conducted a multicenter retrospective analysis of consecutive patients implanted with a Confirm Rx™ ICM (v1.2) across nine UK hospitals, all with documented AF lasting at least 6 min. Electrocardiograms (ECGs) were manually adjudicated by cardiologists. To account for intra‐ and inter‐reviewer variability, a random sample of 10% of ECGs underwent additional review. Disagreements were resolved by a third reviewer. Diagnostic performance was determined by calculating the gross and patient‐averaged positive predictive value (PPV) for AF episodes of different duration. The source of false positive (FP) detection was also categorized. Overall, 16,230 individual ECGs from 232 patients were included. The median AF episode duration was 14 min. R‐wave amplitude remained stable during follow‐up (0.52 ± 0.27 mV [initial] vs. 0.54 ± 0.29 mV [end of follow‐up], p= .10). The gross and patient‐averaged PPV were 75.0% and 67.0%, respectively. Diagnostic performance (gross) increased with progressively longer AF episodes: 88.0% for ≥1 h, 97.3% for 6 h, and 100% for 24 h. The main source of FP during tachycardia was T‐wave oversensing (54.2%), while in non‐tachycardic episodes it was predominantly ectopy (71.2%). The AF burden precision was excellent (93.3%). The Confirm Rx™ ICM diagnostic performance was modest for all AF episodes (75%), with accuracy increasing for longer AF episodes. Analysis of 16,230 ECGs from 232 patients demonstrated that the Confirm Rx™ ICM had a gross positive predictive value of 75%, increasing to 100% for atrial fibrillation (AF) episodes over 24 h. The trend of improving AF detection accuracy with longer episodes was consistent across all implant indications.

Published
2024
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6. A nationwide, population‐based study on specialized care for acute heart failure throughout the COVID‐19 pandemic.

Author

Cannata, Antonio, Mizani, Mehrdad A., Bromage, Daniel I., Piper, Susan E., Hardman, Suzanna M.C., Sudlow, Cathie, de Belder, Mark, Deanfield, John, Gardner, Roy S., Clark, Andrew L., Cleland, John G.F., and McDonagh, Theresa A.

Subjects
COVID-19 pandemic, HEART failure, HEART failure patients, CARDIOVASCULAR disease related mortality, OVERALL survival
Abstract

Aims: The COVID‐19 pandemic disrupted the delivery of care for patients with heart failure (HF), leading to fewer HF hospitalizations and increased mortality. However, nationwide data on quality of care and long‐term outcomes across the pandemic are scarce. Methods and results: We used data from the National Heart Failure Audit (NHFA) linked to national records for hospitalization and deaths. We compared pre‐COVID (2018–2019), COVID (2020), and late/post‐COVID (2021–2022) periods. Data for 227 250 patients admitted to hospital with HF were analysed and grouped according to the admission year and the presence of HF with (HFrEF) or without reduced ejection fraction (non‐HFrEF). The median age at admission was 81 years (interquartile range 72–88), 55% were men (n = 125 975), 87% were of white ethnicity (n = 102 805), and 51% had HFrEF (n = 116 990). In‐hospital management and specialized cardiology care were maintained throughout the pandemic with an increasing percentage of patients discharged on disease‐modifying medications over time (p < 0.001). Long‐term outcomes improved over time (hazard ratio [HR] 0.92, 95% confidence interval [CI] 0.90–0.95, p < 0.001), mainly driven by a reduction in cardiovascular death. Receiving specialized cardiology care was associated with better long‐term outcomes both for those who had HFrEF (HR 0.79, 95% CI 0.77–0.82, p < 0.001) and for those who had non‐HFrEF (HR 0.87, 95% CI 0.85–0.90, p < 0.001). Conclusions: Despite the disruption of healthcare systems, the clinical characteristics of patients admitted with HF were similar and the overall standard of care was maintained throughout the pandemic. Long‐term survival of patients hospitalized with HF continued to improve after COVID‐19, especially for HFrEF. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Guía ESC 2021 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureGrupo de Trabajo de la Sociedad Europea de Cardiología (ESC) de diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónicaDesarrollada con la colaboración especial de la Heart Failure Association (HFA) de la ESC

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Coats, Andrew J.S., Crespo-Leiro, María G., Farmakis, Dimitrios, Gilard, Martine, Heyman, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S.P., Lyon, Alexander R., McMurray, John J.V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Francesco Piepoli, Massimo, Price, Susanna, Rosano, Giuseppe M.C., Ruschitzka, Frank, and Skibelund, Anne Kathrine

Published
2022
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8. A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies

Author

Osmanska, Joanna, primary, Brooksbank, Katriona, additional, Docherty, Kieran F, additional, Robertson, Stacy, additional, Wetherall, Kirsty, additional, McConnachie, Alex, additional, Hu, Jerry, additional, Gardner, Roy S, additional, Clark, Andrew L, additional, Squire, Iain B, additional, Kalra, Paul R, additional, Jhund, Pardeep S, additional, Muntendam, Pieter, additional, McMurray, John J V, additional, Petrie, Mark C, additional, and Campbell, Ross T, additional

Published
2023
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10. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haram, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Crespo-Leiro, María Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S.P., Lyon, Alexander R., McMurray, John J.V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco, Price, Susanna, Rosano, Giuseppe M.C., Ruschitzka, Frank, Skibelund, Anne Kathrine, McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haram, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Crespo-Leiro, María Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S.P., Lyon, Alexander R., McMurray, John J.V., Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco, Price, Susanna, Rosano, Giuseppe M.C., Ruschitzka, Frank, and Skibelund, Anne Kathrine

Published
2023

11. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G.F., Crespo‐Leiro, Maria Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, and Lam, Carolyn S.P.

Subjects
HEART failure, TASK forces, CARDIOLOGY, DIAGNOSIS, ELECTRONIC journals, AFRIKANERS
Abstract

Document Reviewers: Rudolf A. de Boer (CPG Review Co‐ordinator) (Netherlands), P. Christian Schulze (CPG Review Co‐ordinator) (Germany), Elena Arbelo (Spain), Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger (Germany), Sergio Buccheri (Sweden), Elisabetta Cerbai (Italy), Erwan Donal (France), Frank Edelmann (Germany), Gloria Färber (Germany), Bettina Heidecker (Germany), Borja Ibanez (Spain), Stefan James (Sweden), Lars Køber (Denmark), Konstantinos C. Koskinas (Switzerland), Josep Masip (Spain), John William McEvoy (Ireland), Robert Mentz (United States of America), Borislava Mihaylova (United Kingdom), Jacob Eifer Møller (Denmark), Wilfried Mullens (Belgium), Lis Neubeck (United Kingdom), Jens Cosedis Nielsen (Denmark), Agnes A. Pasquet (Belgium), Piotr Ponikowski (Poland), Eva Prescott (Denmark), Amina Rakisheva (Kazakhstan), Bianca Rocca (Italy), Xavier Rossello (Spain), Leyla Elif Sade (United States of America/Türkiye), Hannah Schaubroeck (Belgium), Elena Tessitore (Switzerland), Mariya Tokmakova (Bulgaria), Peter van der Meer (Netherlands), Isabelle C. Van Gelder (Netherlands), Mattias Van Heetvelde (Belgium), Christiaan Vrints (Belgium), Matthias Wilhelm (Switzerland), Adam Witkowski (Poland), and Katja Zeppenfeld (Netherlands) All experts involved in the development of this Focused Update have submitted declarations of interest. These have been compiled in a report and simultaneously published in a supplementary document to the Focused Update. The report is also available on the ESC website www.escardio.org/guidelines See the European Heart Journal online for supplementary documents that include evidence tables. [ABSTRACT FROM AUTHOR]

Published
2024
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15. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A, Metra, Marco, Adamo, Marianna, Gardner, Roy S, Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu, Cleland, John G F, Crespo-Leiro, Maria Generosa, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W, Jaarsma, Tiny, Jankowska, Ewa A, Lainscak, Mitja, and Lam, Carolyn S P

Subjects
HEART failure, TASK forces, MEDICAL care, BRAIN natriuretic factor, MEDICAL personnel, DIAGNOSIS
Abstract

After due deliberation, the Task Force decided to update recommendations for the following sections of the 2021 ESC HF Guidelines: Chronic HF: HF with mildly reduced ejection fraction (HFmrEF) and HFpEF Acute HF Comorbidities and prevention of HF. 3. HF events were defined as HF hospitalizations, urgent HF visits, and unplanned outpatient HF visits. Acute heart failure Treatment of acute HF was outlined in the recent 2021 ESC HF Guidelines and a Heart Failure Association scientific statement on HF.[1],[25] Since these publications, trials have been conducted with diuretics, as well as on management strategies for patients with acute HF. [Extracted from the article]

Published
2023
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16. A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies

Author

Osmanska, Joanna, Brooksbank, Katriona, Docherty, Kieran F, Robertson, Stacy, Wetherall, Kirsty, McConnachie, Alex, Hu, Jerry, Gardner, Roy S, Clark, Andrew L, Squire, Iain B, Kalra, Paul R, Jhund, Pardeep S, Muntendam, Pieter, McMurray, John J V, Petrie, Mark C, and Campbell, Ross T

Abstract

Graphical Abstract

Published
2024
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18. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Boehm, Michael, Burri, Haran, Butler, Javed, Celutkien, Jelena, Chioncel, Ovidiu, Cleland, John G. F., Coats, Andrew J. S., Crespo-Leiro, Maria G., Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S. P., Lyon, Alexander R., McMurray, John J. V, Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Francesco Piepoli, Massimo, Price, Susanna, Rosano, Giuseppe M. C., Ruschitzka, Frank, Skibelund, Anne Kathrine, McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Boehm, Michael, Burri, Haran, Butler, Javed, Celutkien, Jelena, Chioncel, Ovidiu, Cleland, John G. F., Coats, Andrew J. S., Crespo-Leiro, Maria G., Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S. P., Lyon, Alexander R., McMurray, John J. V, Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Francesco Piepoli, Massimo, Price, Susanna, Rosano, Giuseppe M. C., Ruschitzka, Frank, and Skibelund, Anne Kathrine

Abstract

n/a, All experts involved in the development of these guidelines have submitted declarations of interest. These have been compiled in a report and published in a supplementary document simultaneously to the guidelines. The report is also available on the ESC website www.escardio.org/guidelines (C) For the Supplementary Data which include background information and detailed discussion of the data that have provided the basis for the guidelines see European Heart Journal online

Published
2022
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19. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A, Metra, Marco; https://orcid.org/0000-0001-6691-8568, Adamo, Marianna, Gardner, Roy S, Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu; https://orcid.org/0000-0002-3197-3628, Cleland, John G F; https://orcid.org/0000-0002-1471-7016, Coats, Andrew J S; https://orcid.org/0000-0002-2771-4260, Crespo-Leiro, Maria G; https://orcid.org/0000-0002-3085-167X, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W, Jaarsma, Tiny, Jankowska, Ewa A; https://orcid.org/0000-0002-9202-432X, Lainscak, Mitja; https://orcid.org/0000-0002-5922-4098, Lam, Carolyn S P, Lyon, Alexander R; https://orcid.org/0000-0001-8026-840X, McMurray, John J V, Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco; https://orcid.org/0000-0003-1124-234X, Price, Susanna, Rosano, Giuseppe M C, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Skibelund, Anne Kathrine, McDonagh, Theresa A, Metra, Marco; https://orcid.org/0000-0001-6691-8568, Adamo, Marianna, Gardner, Roy S, Baumbach, Andreas, Böhm, Michael, Burri, Haran, Butler, Javed, Čelutkienė, Jelena, Chioncel, Ovidiu; https://orcid.org/0000-0002-3197-3628, Cleland, John G F; https://orcid.org/0000-0002-1471-7016, Coats, Andrew J S; https://orcid.org/0000-0002-2771-4260, Crespo-Leiro, Maria G; https://orcid.org/0000-0002-3085-167X, Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W, Jaarsma, Tiny, Jankowska, Ewa A; https://orcid.org/0000-0002-9202-432X, Lainscak, Mitja; https://orcid.org/0000-0002-5922-4098, Lam, Carolyn S P, Lyon, Alexander R; https://orcid.org/0000-0001-8026-840X, McMurray, John J V, Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco; https://orcid.org/0000-0003-1124-234X, Price, Susanna, Rosano, Giuseppe M C, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, and Skibelund, Anne Kathrine

Abstract

Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator) (Netherlands), P. Christian Schulze (CPG Review Coordinator) (Germany), Magdy Abdelhamid (Egypt), Victor Aboyans (France), Stamatis Adamopoulos (Greece), Stefan D. Anker (Germany), Elena Arbelo (Spain), Riccardo Asteggiano (Italy), Johann Bauersachs (Germany), Antoni Bayes-Genis (Spain), Michael A. Borger (Germany), Werner Budts (Belgium), Maja Cikes (Croatia), Kevin Damman (Netherlands), Victoria Delgado (Netherlands), Paul Dendale (Belgium), Polychronis Dilaveris (Greece), Heinz Drexel (Austria), Justin Ezekowitz (Canada), Volkmar Falk (Germany), Laurent Fauchier (France), Gerasimos Filippatos (Greece), Alan Fraser (United Kingdom), Norbert Frey (Germany), Chris P. Gale (United Kingdom), Finn Gustafsson (Denmark), Julie Harris (United Kingdom), Bernard Iung (France), Stefan Janssens (Belgium), Mariell Jessup (United States of America), Aleksandra Konradi (Russia), Dipak Kotecha (United Kingdom), Ekaterini Lambrinou (Cyprus), Patrizio Lancellotti (Belgium), Ulf Landmesser (Germany), Christophe Leclercq (France), Basil S. Lewis (Israel), Francisco Leyva (United Kingdom), AleVs Linhart (Czech Republic), Maja-Lisa Løchen (Norway), Lars H. Lund (Sweden), Donna Mancini (United States of America), Josep Masip (Spain), Davor Milicic (Croatia), Christian Mueller (Switzerland), Holger Nef (Germany), Jens-Cosedis Nielsen (Denmark), Lis Neubeck (United Kingdom), Michel Noutsias (Germany), Steffen E. Petersen (United Kingdom), Anna Sonia Petronio (Italy), Piotr Ponikowski (Poland), Eva Prescott (Denmark), Amina Rakisheva (Kazakhstan), Dimitrios J. Richter (Greece), Evgeny Schlyakhto (Russia), Petar Seferovic (Serbia), Michele Senni (Italy), Marta Sitges (Spain), Miguel Sousa-Uva (Portugal), Carlo G. Tocchetti (Italy), Rhian M. Touyz (United Kingdom), Carsten Tschoepe (Germany), Johannes Waltenberger (Germany/Switzerland) All experts involved in the development of these guidelines have submitted declarations of inte

Published
2022

20. Adherence to prescribed medications in patients with heart failure – insights from liquid chromatography-tandem mass spectrometry-based urine analysis

Author

Simpson, Joanne, Jackson, Colette E., Haig, Caroline, Jhund, Pardeep S., Tomaszewski, Maciej, Gardner, Roy S., Tsorlalis, Yannis, Petrie, Mark C., McMurray, John J.V., Squire, Iain B., and Gupta, Pankaj

Abstract

Aims: \ud None of the existing studies on adherence have directly measured levels of medications (or their metabolites) in patients with heart failure.\ud \ud Methods and Results: \ud We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4 to 6 weeks after hospitalisation with heart failure. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only 7 out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed heart failure drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients.\ud \ud Conclusion: \ud Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in 1 of 5 patients evaluated 4 to 6 weeks after hospitalisation with heart failure.

Published
2021

22. Real‐world evidence in a national health service: results of the UK CardioMEMS HF System Post‐Market Study

Author

Cowie, Martin R., primary, Flett, Andrew, additional, Cowburn, Peter, additional, Foley, Paul, additional, Chandrasekaran, Badrinathan, additional, Loke, Ian, additional, Critoph, Chris, additional, Gardner, Roy S., additional, Guha, Kaushik, additional, Betts, Tim R., additional, Carr‐White, Gerry, additional, Zaidi, Amir, additional, Lim, Hoong Sern, additional, Hayward, Carl, additional, Patwala, Ashish, additional, Rogers, Dominic, additional, Pettit, Stephen, additional, Gazzola, Carlo, additional, Henderson, John, additional, and Adamson, Philip B., additional

Published
2021
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23. Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A, primary, Metra, Marco, additional, Adamo, Marianna, additional, Gardner, Roy S, additional, Baumbach, Andreas, additional, Böhm, Michael, additional, Burri, Haran, additional, Butler, Javed, additional, Čelutkienė, Jelena, additional, Chioncel, Ovidiu, additional, Cleland, John G F, additional, Coats, Andrew J S, additional, Crespo-Leiro, Maria G, additional, Farmakis, Dimitrios, additional, Gilard, Martine, additional, Heymans, Stephane, additional, Hoes, Arno W, additional, Jaarsma, Tiny, additional, Jankowska, Ewa A, additional, Lainscak, Mitja, additional, Lam, Carolyn S P, additional, Lyon, Alexander R, additional, McMurray, John J V, additional, Mebazaa, Alexandre, additional, Mindham, Richard, additional, Muneretto, Claudio, additional, Francesco Piepoli, Massimo, additional, Price, Susanna, additional, Rosano, Giuseppe M C, additional, Ruschitzka, Frank, additional, and Kathrine Skibelund, Anne, additional

Published
2021
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24. Clinical characteristics and outcomes of patients with angina and heart failure in the CHARM (Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity) Programme

Author

Badar, Athar A., Perez-Moreno, Ana C., Hawkins, Nathaniel M., Brunton, Alan P.T., Jhund, Pardeep S., Wong, Chih M., Solomon, Scott D., Granger, Christopher B., Yusuf, Salim, Pfeffer, Marc A., Swedberg, Karl, Gardner, Roy S., Petrie, Mark C., and McMurray, John J.V.

Published
2015
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25. Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: an analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)

Author

Badar, Athar A., Perez-Moreno, Ana Cristina, Jhund, Pardeep S., Wong, Chih M., Hawkins, Nathaniel M., Cleland, John G.F., van Veldhuisen, Dirk J., Wikstrand, John, Kjekshus, John, Wedel, Hans, Watkins, Stuart, Gardner, Roy S., Petrie, Mark C., and McMurray, John J.V.

Published
2014
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26. Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)

Author

Wong, Chih M., Hawkins, Nathaniel M., Petrie, Mark C., Jhund, Pardeep S., Gardner, Roy S., Ariti, Cono A., Poppe, Katrina K., Earle, Nikki, Whalley, Gillian A., Squire, Iain B., Doughty, Robert N., McMurray, John J.V., Berry, C., Doughty, R., Granger, C., Køber, L., Massie, B., McAlister, F., McMurray, J., Pocock, S., Poppe, K., Swedberg, K., Somaratne, J., Whalley, G., Ahmed, A., Andersson, B., Bayes-Genis, A., Berry, C., Cowie, M., Cubbon, R., Doughty, R., Ezekowitz, J., Gonzalez-Juanatey, J., Gorini, M., Gotsman, I., Grigorian-Shamagian, L., Guazzi, M., Kearney, M., Køber, L., Komajda, M., di Lenarda, A., Lenzen, M., Lucci, D., Macín, S., Madsen, B., Maggioni, A., Martínez-Sellés, M., McAlister, F., Oliva, F., Poppe, K., Rich, M., Richards, M., Senni, M., Squire, I., Taffet, G., Tarantini, L., Tribouilloy, C., Troughton, R., Tsutsui, H., Whalley, G., Doughty, R., Earle, N., Gamble, G.D., Poppe, K., Whalley, G., Ariti, C., Dobson, J., Pocock, S., Poppe, K., Doughty, R.N., Whalley, G., Andersson, B., Hall, C., Richards, A.M., Troughton, R., Lainchbury, J., Berry, C., Hogg, K., Norrie, J., Stevenson, K., Brett, M., McMurray, J., Pfeffer, M.A., Swedberg, K., Granger, C.B., Held, P., McMurray, J.J.V., Michelson, E.L., Olofsson, B., Östergren, J., Yusuf, S., Køber, L., Torp-Pedersen, C., Ahmed, Ali, Lenzen, M.J., Scholte op Reimer, W.J.M., Boersma, E., Vantrimpont, P.J.M.J., Follath, F., Swedberg, K., Cleland, J., Komajda, M., Gotsman, I., Zwas, D., Planer, D., Azaz-Livshits, T., Admon, D., Lotan, C., Keren, A., Grigorian-Shamagian, L., Varela-Roman, A., Mazón-Ramos, P., Rigeiro-Veloso, P., Bandin-Dieguez, M.A., Gonzalez-Juanatey, J.R., Guazzi, M., Myers, J., Arena, R., McAlister, F.A., Ezekowitz, J., Armstrong, P.W., Cujec, Bibiana, Paterson, Ian, Cowie, M.R., Wood, D.A., Coats, A.J.S., Thompson, S.G., Suresh, V., Poole-Wilson, P.A., Sutton, G.C., Martínez-Sellés, M., Robles, J.A.G., Prieto, L., Muñoa, M.D., Frades, E., Díaz-Castro, O., Almendral, J., Tarantini, L., Faggiano, P., Senni, M., Lucci, D., Bertoli, D., Porcu, M., Opasich, C., Tavazzi, L., Maggioni, A.P., Kirk, V., Bay, M., Parner, J., Krogsgaard, K., Herzog, T.M., Boesgaard, S., Hassager, C., Nielsen, O.W., Aldershvile, J., Nielsen, H., Kober, L., Macín, S.M., Perna, E.R., Cimbaro Canella, J.P., Alvarenga, P., Pantich, R., Ríos, N., Farias, E.F., Badaracco, J.R., Madsen, B.K., Hansen, J.F., Stokholm, K.H., Brons, J., Husum, D., Mortensen, L.S., Bayes-Genis, A., Vazquez, R., Puig, T., Fernandez-Palomeque, C., Bardají, A., Pascual-Figal, D., Ordoñez-Llanos, J., Valdes, M., Gabarrus, A., Pavon, R., Pastor, L., Gonzalez-Juanatey, J.R., Almendral, J., Fiol, M., Nieto, V., Macaya, C., Cinca, J., Bayes de Luna, A., Newton, J.D., Blackledge, H.M., Squire, I.B., Wright, S.P., Whalley, G.A., Doughty, R.N., Kerzner, R., Gage, B.F., Freedland, K.E., Rich, M.W., Huynh, B.C., Rovner, A, Freedland, KE, Carney, RM, Rich, MW, Taffet, GE, Teasdale, T.A., Bleyer, A.J., Kutka, N.J., Luchi, R.J., Tribouilloy, C., Rusinaru, D., Mahjoub, H., Soulière, V., Lévy, F., Peltier, M., Tsutsui, H., Tsuchihashi, M., Takeshita, A., MacCarthy, P.A., Kearney, M.T., Nolan, J., Lee, A.J., Prescott, R.J., Shah, A.M., Brooksby, W.P., Fox, K.A.A., Varela-Roman, A., Gonzalez-Juanatey, J.R., Basante, P., Trillo, R., Garcia-Seara, J., Martinez-Sande, J.L., and Gude, F.

Published
2014
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34. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: : Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Author

McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Boehm, Michael, Burri, Haran, Butler, Javed, Celutkiene, Jelena, Chioncel, Ovidiu, Cleland, John G. F., Coats, Andrew J. S., Crespo-Leiro, Maria G., Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S. P., Lyon, Alexander R., McMurray, John J. V, Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco, Price, Susanna, Rosano, Giuseppe M. C., Ruschitzka, Frank, Skibelund, Anne Kathrine, McDonagh, Theresa A., Metra, Marco, Adamo, Marianna, Gardner, Roy S., Baumbach, Andreas, Boehm, Michael, Burri, Haran, Butler, Javed, Celutkiene, Jelena, Chioncel, Ovidiu, Cleland, John G. F., Coats, Andrew J. S., Crespo-Leiro, Maria G., Farmakis, Dimitrios, Gilard, Martine, Heymans, Stephane, Hoes, Arno W., Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lam, Carolyn S. P., Lyon, Alexander R., McMurray, John J. V, Mebazaa, Alexandre, Mindham, Richard, Muneretto, Claudio, Piepoli, Massimo Francesco, Price, Susanna, Rosano, Giuseppe M. C., Ruschitzka, Frank, and Skibelund, Anne Kathrine

Abstract

n/a

Published
2021
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35. Chronic heart failure: epidemiology, investigation and management

Author

Beggs, Simon A.S., McDonagh, Theresa A., and Gardner, Roy S.

Subjects
03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, General Medicine, 030204 cardiovascular system & hematology
Abstract

Heart failure (HF) is a clinical syndrome characterized by dyspnoea, fatigue and fluid retention accompanied by objective evidence of cardiac dysfunction. The syndrome affects around 2% of the adult population, men more commonly than women (

Published
2018
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40. Multiparameter diagnostic sensor measurements during clinically stable periods and worsening heart failure in ambulatory patients

Author

Gardner, Roy S., primary, Thakur, Pramodsingh, additional, Hammill, Eric F., additional, Nair, Devi G., additional, Eldadah, Zayd, additional, Stančák, Branislav, additional, Ferrick, Kevin, additional, Sriratanasathavorn, Charn, additional, Duray, Gábor Zoltán, additional, Wariar, Ramesh, additional, Zhang, Yi, additional, An, Qi, additional, Averina, Viktoria, additional, and Boehmer, John P., additional

Published
2021
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42. Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography–tandem mass spectrometry-based urine analysis

Author

Simpson, Joanne, primary, Jackson, Colette E, additional, Haig, Caroline, additional, Jhund, Pardeep S, additional, Tomaszewski, Maciej, additional, Gardner, Roy S, additional, Tsorlalis, Yannis, additional, Petrie, Mark C, additional, McMurray, John J V, additional, Squire, Iain B, additional, and Gupta, Pankaj, additional

Published
2020
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43. Haemodynamic monitoring of cardiac status using heart sounds from an implanted cardiac device

Author

Thakur, Pramodsingh H., An, Qi, Swanson, Lynne, Zhang, Yi, and Gardner, Roy S.

Subjects
Heart sound, Swine, Systolic time interval, Hemodynamic Monitoring, Hemodynamics, Myocardial Ischemia, Heart failure, Pulmonary Edema, Contractility, Pulmonary congestion, Disease Models, Animal, Dogs, Original Research Articles, Acute Disease, Animals, Original Research Article, Cardiac Resynchronization Therapy Devices
Abstract

Aim The aim of this study was to evaluate the haemodynamic correlates of heart sound (HS) parameters such as third HS (S3), first HS (S1), and HS‐based systolic time intervals (HSTIs) from an implantable cardiac device. Methods and results Two unique animal models (10 swine with myocardial ischaemia and 11 canines with pulmonary oedema) were used to evaluate haemodynamic correlates of S1, S3, and HSTIs, namely, HS‐based pre‐ejection period (HSPEP), HS‐based ejection time (HSET), and the ratio HSPEP/HSET during acute haemodynamic perturbations. The HS was measured using implanted cardiac resynchronization therapy defibrillator devices simultaneously with haemodynamic references such as left atrial (LA) pressure and left ventricular (LV) pressure. In the ischaemia model, S1 amplitude (r = 0.76 ± 0.038; P = 0.002), HSPEP (r = −0.56 ± 0.07; P = 0.002), and HSPEP/HSET (r = −0.42 ± 0.1; P = 0.002) were significantly correlated with LV dP/dtmax. In contrast, HSET was poorly correlated with LV dP/dtmax (r = 0.14 ± 0.14; P = 0.23). In the oedema model, a physiological delayed response was observed in S3 amplitude after acute haemodynamic perturbations. After adjusting for the delay, S3 amplitude significantly correlated with LA pressure in individual animals (r = 0.71 ± 0.07; max: 0.92; min: 0.17) as well as in aggregate (r = 0.62; P 25 mmHg, with a sensitivity = 58% and specificity = 90%. Conclusions The HS parameters such as S1, S3, and HSTIs measured using implantable devices significantly correlated with haemodynamic changes in acute animal models, suggesting potential utility for remote heart failure patient monitoring.

Published
2017

47. Ferumoxytol-enhanced Magnetic Resonance Imaging in Patients with Prior Cardiac Transplantation

Author

Stirrat, Colin, Alam, Shirjel, MacGillivray, Thomas, Gray, Calum, Dweck, Marc, Jones, Victor, Wallace, William, Payne, John, Prasad, Sanjay, Gardner, Roy S, Petrie, Mark C., Mirsadraee, Saeed, Henriksen, Peter, Semple, Scott, and Newby, David

Abstract

Objectives: Ultra-small superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect cellular inflammation within tissues and may help non-invasively identify cardiac transplant rejection. Here, we aimed to determine the normal reference values for USPIO-enhanced MRI in patients with a prior cardiac transplant and examine whether USPIO-enhanced MRI could detect myocardial inflammation in patients with transplant rejection.Methods: Ten volunteers and 11 patients with cardiac transplant underwent T2, T2* and late gadolinium enhancement 1.5T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months.Results: Ten patients with clinically stable cardiac transplantation were retained for analysis. Myocardial T2 values were higher in patients with cardiac transplant versus healthy volunteers (53.8±5.2 vs 48.6±1.9 ms, respectively; p=0.003). There were no differences in the magnitude of USPIO-induced change in R2* in patients with transplantation (change in R2*, 26.6±7.3 vs 22.0±10.4 s-1 in healthy volunteers; p=0.28). After 3 months, patients with transplantation (n=5) had unaltered T2 values (52.7±2.8 vs 52.12±3.4 ms; p=0.80) and changes in R2* following USPIO (29.42±8.14 vs 25.8±7.8 s-1; p=0.43).Conclusion: Stable patients with cardiac transplantation have increased myocardial T2 values, consistent with resting myocardial oedema or fibrosis. In contrast, USPIO-enhanced MRI is normal and stable over time suggesting the absence of chronic macrophage-driven cellular inflammation. It remains to be determined whether USPIO-enhanced MRI may be able to identify acute cardiac transplant rejection.Trial registration number: NCT02319278349 (https://clinicaltrials.gov/ct2/show/NCT02319278) Registered 03.12.2014 EUDraCT 2013-002336-24.

Published
2019
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