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8 results on '"Gallavardin, Thibault"'

3. Two‐Photon Absorption and Cell Imaging of Fluorene‐Functionalized Epicocconone Analogues

Author

Oger, Samuel, Schapman, Damien, Mougeot, Romain, Leleu, Stéphane, Lascoux, Noëlle, Baldeck, Patrice, Bénard, Magalie, Gallavardin, Thibault, Galas, Ludovic, Franck, Xavier, Oger, Samuel, Schapman, Damien, Mougeot, Romain, Leleu, Stéphane, Lascoux, Noëlle, Baldeck, Patrice, Bénard, Magalie, Gallavardin, Thibault, Galas, Ludovic, and Franck, Xavier

Abstract

info:eu-repo/semantics/published

Published
2019

7. Indazole versus indole-based cationic merocyanines with red shifted in-cellulo emission for selective mitochondria imaging

Author

Ludovic Galas, Magalie Bénard, Xavier Franck, Margot Boujut, Thibault Gallavardin, Arnaud Chevalier, Damien Schapman, Gallavardin, Thibault, Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut de Chimie Organique Fine (IRCOF), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Plate-Forme de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-High-tech Research Infrastructures for Life Sciences (HeRacLeS), and Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Indole test, Indazole, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Process Chemistry and Technology, General Chemical Engineering, Cationic polymerization, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Fluorophore, Mitochondrion, [CHIM.ORGA] Chemical Sciences/Organic chemistry, Photochemistry, Mitochondria, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry, chemistry.chemical_compound, Membrane, chemistry, Cationic merocyanine dyes, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Molecule, Cellular biology, Merocyanine, Electrochemical potential
Abstract

International audience; Selective fluorophores are seminal for the development of fluorescent cell imaging allowing the simultaneous monitoring of several biological parameters. Mitochondria are one of the main targets of optical microscopy as their dynamics are related to many biological events. One of the best strategy to target them, is to design cationic dyes which accumulate preferentially in their membranes due to their high electrochemical potential. In this work, indazole scaffold was explored to build new cationic merocyanine dyes and compared with indole scaffold. This nitrogen heteroaromatic structure is still very uncommon in dyes chemistry; therefore, a lot has to be discovered about the effects of pH, solvent polarity and methylation in cyclic nitrogen on their optical properties. Finally, fluorescent imaging revealed that a red shift occurred in the emission of these molecules inside the mitochondria.

Published
2022

8. An optimized procedure for direct access to 1 H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles.

Author

Chevalier A, Ouahrouch A, Arnaud A, Gallavardin T, and Franck X

Abstract

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1 H -indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1 H -indazole-3-carboxaldehydes., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Published
2018
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