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Immune Thrombocytopenia (ITP) which is a common, acquired and autoimmune disease is defined as low platelet count secondary to increased platelet destruction or impaired thrombopoiesis by anti-thromboycte antibodies. Pregnancy-associated thrombocytopenia accounts for 5% of all the cases. Thrombopoietin (TPO) mimetic drugs, such as Eltrombopag, have been used successfully in many patients with ITP; however data on its use in pregnancy is limited. In this report, a case who was followed up with ITP and given Eltrombopag during her pregnancy, cause it could not have been controlled by any other treatment is presented. Enoxaparin therapy was iniatiated for thromboprophylaxis after the patient’s platelet count responded to Eltrombopag treatment. Delivery was carried out by cesarean section. Baby was born with low birth weight and there was not any malformation. Nevertheless, further research is needed to find out whether there is a relationship between Eltrombopag use in pregnancy and low birth weight.

Objectives: Primary central nervous system lymphoma (PCNSL) is a rare malignant disease with poor prognosis. Its low incidence leads to challenges in decision-making for treatment. As a matter of fact, there is still no consensus on the appropriate treatment modalities. In this context, the objective of this study is to investigate and comparatively assess the efficacies of several treatment modalities in the treatment of PCNSL. Methods: Thirty-four patients diagnosed with PCNSL at 5 different hematology centers between 2007 and 2021 were included in the study. Patients’ data from all five centers were collected retrospectively. Since ibrutinib is not approved for this indication in Turkey, consent for off-label use of ibrutinib is obtained from each patient. Ethics committee ap-proval was obtained on June 9, 2021 with decision number 2021/18-05. Results: The median age of the patients was 59 (min.: 22, max.: 78) years. The male-to-female ratio was 1.26/1. Nineteen (55.9%) patients had Eastern Cooperative Oncology Group (ECOG) performance score of ≥2. Fifteen (44.1%) patients had normal lactate dehydrogenase (LDH) levels and only 14.7% of the patients had B symptoms at the time of diagnosis. Magnetic resonance imaging (MRI) revealed a single mass lesion in 14 (41.2%) patients. As an induction therapy, meth-otrexate-based regimen was administered in 29 (85.3%) patients. Only 14 of the 34 patients received 4 or more cycles of high-dose methotrexate (MTX). About 32.4% of the patients received radiation therapy (RT) during follow-up as a part of induction therapy. Five patients received only RT due to poor performance status. Ibrutinib was administered in 5 patients for refractory disease. It was determined that four or more cycles of MTX treatment increased progression-free survival (PFS) (p=0.031) and overall survival (OS) (p=0.012). Moreover, RT improved PFS (p=0.023). Considering that the complete response achieved by induction therapy influences long-term survival, achievement of the best response to the treatment regimens administered in combination with new agents may prolong survival (PFS: p=0.01, OS: p=0.023). Conclusion: The findings of this study indicate that the initial response to treatment is crucial. Additionally, it was found that high-dose MTX treatment should be administered for 4 cycles or more in order to achieve the best results. Furthermore, it was determined that ibrutinib monotherapy was well-tolerated in our patients with relapsed/refractory disease, with excellent clinical benefits. In conclusion, a combination therapy consisting of high-dose MTX, ibrutinib, and rituximab appears to be a promising initial treatment approach in appropriate patients.

Treatment free remission (TFR) is one of the main goals of therapy in Chronic Myeloid Leukemia (CML). Patient perspective and expectations have an indicative effect on discontinuation decisions. We analyzed 116 CML patients' perspective on TFR and factors that associated with willingness for tyrosine kinaz inhibitor (TKI) discontinuation from four different center in Turkey based on a national survey. Patients in our cohort had 7.8% awareness of TFR and after brief information willingness to attempt TFR has been reached to 58.9% in all population. Shorter disease duration was associated with enhanced willingness to attempt discontinuation in multivariate analyses (p=0.031). Most common patient related limitation for TKI discontinuation decision was anxiety about disease relaps and TKI resistance. Even disease relaps in TFR means molecular and detectable with close monitoring, patients still had considerable concerns about TKI discontinuation.

Immune Thrombocytopenia (ITP) which is a common, acquired and autoimmune disease is defined as low platelet count secondary to increased platelet destruction or impaired thrombopoiesis by anti-thromboycte antibodies. Pregnancy-associated thrombocytopenia accounts for 5% of all the cases. Thrombopoietin (TPO) mimetic drugs, such as Eltrombopag, have been used successfully in many patients with ITP; however data on its use in pregnancy is limited. In this report, a case who was followed up with ITP and given Eltrombopag during her pregnancy, cause it could not have been controlled by any other treatment is presented. Enoxaparin therapy was iniatiated for thromboprophylaxis after the patient’s platelet count responded to Eltrombopag treatment. Delivery was carried out by cesarean section. Baby was born with low birth weight and there was not any malformation. Nevertheless, further research is needed to find out whether there is a relationship between Eltrombopag use in pregnancy and low birth weight.

Topu, kafa veya ayak vuruşları ile karşı kaleye sokma kuralına dayanan ve on birer kişilik iki takım arasında oynanan top oyunu anlamına gelen futbol, ortaya çıkışı itibariyle M.Ö. 2500'lü yıllara dayanan eski bir tarihe sahiptir. Günümüz futbolu ortaya çıkmadan önce insanların ilk olarak futbolu, topu ayakla tekmelemek suretiyle yere dikilmiş iki mızrak arasından geçirmeye çalışmak şeklinde oynadığı görülmüştür. İnsanların aldığı haz ile orantılı olarak futbola daha fazla önem vermesi, futbolu zamanla diğer spor dallarından ayırmış ve 1857 yılında İngiltere'de futbol federasyonun kurulması ile modern anlamda futbol ortaya çıkmıştır.Futbol dünyada değişik ülkelerde değişik zamanlarda yayılmakla beraber Türkiye'de futbola ilk olarak 1875 yılında Osmanlı topraklarında ve yine 1877 yılında İzmir'in Bornova çayırlarında futbol turnuvalarının düzenlenmesi ile rastlanmıştır. Futbol kulüpleri ilk olarak 5253 sayılı Dernekler Kanununun ?Gençlik ve Spor Kulüpleri? başlıklı 14. maddesinde düzenlemeye konu olmuştur. Bu kanunda; futbol kulüplerinin finansal yapılarına ilişkin çeşitli düzenlemeler ile birlikte, kulüplerin gelir ve gider unsurlarının neler olduğu, gelirlerin elde edilmesinde ve harcamaların yapılmasında hangi usullere göre hareket edilmesi gerektiği konularına yer verilmiştir. Bu konular kanunda düzenlenmekle beraber, futbolun gelişen ekonomik yapısı çerçevesinde söz konusu düzenlemelerin futbolun finansal yapısını şeffaf bir şekilde ortaya koymada yetersiz kaldığı görülmüştür.Futbolun bir spor dalından çok ekonomik bir sektöre dönüştüğü ve bununla birlikte büyük bütçeye sahip olduğu göz önüne alındığında futbol kulüplerinin muhasebe yapılarında mevcut olan bir takım eksikliklerin ortadan kaldırılması amacıyla futbol kulüplerine Tekdüzen Muhasebe Sistemindeki hesaplara uygun alt hesaplar kullanılmak suretiyle yeni bir muhasebe sistemi önerilmiştir. Böylelikle futbol kulüplerinin muhasebe sistemleri ve finansal yapıları daha şeffaf bir yapıya kavuşturularak finansal çıktıların bilgi kullanıcılarına sunulması amaçlanmıştır.Anahtar Kelimeler: Futbol, Futbol Kulüpleri, Futbolun Finansal Yapısı, Muhasebe Sistemi Football, which is based on inserting the ball into opposing goal by headers or kicks and played between two teams of eleven players, was emerged approximately in B.C. 2500. Before contemporary football was emerged, people had played football by kicking the ball and trying to pass it through between two spears. In proportion to pleasure that people had, they had attached more importance to football, by passage of time football has been detached from the other sport branches and football in modern sense has been emerged with the foundation of football federation in England, in 1857.Although football has been spread in various countries in different times, it is encountered in Turkey first in 1875 in Ottoman Empire and by football tournaments played in Bornova fields of Izmir in 1877. Football Clubs had been first regulated by 14th clause of Law No. 5253 on Associations, entitled ?Youth and Sport Clubs?. In this law; together with the regulations for the financial standings of football clubs, what income and expenditure components of clubs are and what is needed to have an income and which procedures will be used for expenditures were discussed. Together with the regulation of these laws, in the frame of developing economic structure of football, the said regulations were not enough to introduce the transparent financial structure of football.When football is considered as a growing sector than a sport branch and nonetheless having a big budget, a new accounting system for the clubs were offered to eliminate some deficiencies in accounting structures of football clubs by using below-the-line accounts appropriate to Uniform Accounting System. In this way, it is aimed to submit financial printouts to information users by placing accounting systems and financial structures of football clubs on a transparent footing.Key Words: Football, Football Clubs, Football's Financial Structure, Accounting System 135