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Introduction: The efficacy and safety of ainuovirine+lamivudine+tenofovir (ANV+3TC+TDF) and efavirenz+lamivudine+tenofovir (EFV+3TC+TDF) have been confirmed in previous clinical trials; however, there are no related studies on patient‐reported outcomes. This study aimed to evaluate the effectiveness and safety of these 2 antiretroviral therapy regimens and to understand the patient's symptom experience and subjective experience of sleep quality through patient‐reported outcomes. Methods: This is a single‐center prospective cohort study with 243 patients evaluated from October 1, 2021 to June 30, 2022. Virological effectiveness and patient‐reported outcomes results were analyzed. The primary endpoint was the proportion of HIV viral load <50 copies/mL (virological suppression rate) at 48 weeks and the changes in the HIV symptom index and Pittsburgh sleep quality index. Results: The virological suppression rates in the ANV+3TC+TDF and EFV+3TC+TDF groups were 83.6% (102/122) and 87.6% (106/121), respectively, at 48 weeks. In the ANV+3TC+TDF group, the scores of HIV symptom index and pittsburgh sleep quality index in the 48th week were lower than the baseline level (p < 0.05). Logistic regression results showed that the baseline regimen EFV+3TC+TDF was a risk factor for dizziness/lightheadedness (odds ratio = 3.153, 95% confidence interval: 1.473–6.748, p = 0.003), sadness/depression odds ratio = 2.404, 95% confidence interval:1.188–4.871, p = 0.015), and difficulty sleeping (odds ratio = 2.802, 95% confidence interval: 1.437–5.463, p = 0.002) at 48 weeks. Conclusions: Both regimens showed good virological effectiveness; however, compared with ANV+3TC+TDF, the EFV+3TC+TDF regimen reduced the prevalence of HIV‐related symptoms. [ABSTRACT FROM AUTHOR]

The study block opens up with the already found oil reservation, through the comprehensive analysis to seismic, well logging, well log and core data, collate and stipulate the system of fault, and then make sure the oil source fault; Meanwhile we make use of Geo-Office and Jason multiply technology, to launch micro faces and single sand body spread research. The result shows that, the study block mostly have 4 kinds of oil reservation: fault-lithologic, fault block, fault-screened and lithologic reservoir, the main target layer is Fuyu oil layer of Quantou Formation 3 and 4 part, the reservation and spread of oil is mainly controlled by the distance to the oil source, the space spread which is coordinated to form transportation system by fault concentrated belt and sand body, the high fault block trap. The oil reservation mainly exist in the internal part of fault concentrated belt and the sand body nearby, all in all the spread feature shows that the oil stays above and the water keeps low, and the formations which includes oil becomes less and less from the downstructure location to the updip; The major period for hydrocarbon accumulation is the late period of the Mingshui Formation deposition; Here are the modes of the oil transformation and reservation : the oil goes downward and flow backward and transforms into Fuyu formation, which origins from the source rocks of Qingl member in Sanzhao depression, under the abnormal pressure through the source fault, and then the oil in Fuyu formation of Sanzhao depression transforms to study block under the affect of floatage along the two fault concentrated belt which was linked up by the sand body, at the upstructure location lithology or fault aligns with lithology forms the trap which keeps together to oil reservation.

Loxoprofen sodium (LOX) is a propionic acid derivative non-steroidal anti-inflammatory drug (NSAID), existing in the form of four stereoisomers. The main metabolites of LOX in vivo were trans - and cis -alcohol, each consisting of four stereoisomers. The objectives of the present study were to examine the selective pharmacokinetic behavior of LOX stereoisomers and stereoselective formation of its alcohol metabolites in rats based on a chiral liquid chromatographytandem mass spectrometry (LC-MS/MS) method by using an FLM Chiral NQ-RH column, which was reported for the first time. The significant difference in pharmacokinetic parameters of four stereoisomers indicated that stereoselective behavior has occurred in rats after oral administration of LOX. (1′ S ,2 S)-LOX showed the highest concentration among the four stereoisomers in both plasma and urine samples. Trans - and cis -alcohol metabolites of LOX were also detected in plasma and urine, and trans -alcohol was found to be primary and the stereoisomeric fractions (SF s) of its four stereoisomers at different times were calculated. Examination of the stereoisomeric composition indicated a stereo preference for (2 S)-configuration with respect to trans -alcohol formation. The overall results of the present study revealed the enantioselective pharmacokinetic properties of LOX stereoisomers in rats, which provided a means to advance understanding of the complex pharmacokinetic of LOX. [ABSTRACT FROM AUTHOR]