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4. Brucella melitensis prosthetic joint infection in a traveller returning to the UK from Thailand: Case report and review of the literature

Author

Lewis, Joseph M, Folb, Jonathan, Kalra, Sanjay, Squire, Bertie, Taegtmeyer, Miriam, and Beeching, Nicholas

Subjects
Adult, Male, Prosthetic joint infection, Prosthesis-Related Infections, Returning traveller, we_870, Article, Brucellosis, Young Adult, Brucella melitensis, Animals, Humans, Aged, Travel, wa_108, Public Health, Environmental and Occupational Health, Middle Aged, Thailand, United Kingdom, wc_310, Infectious Diseases, Doxycycline, Travel medicine, Female, Joints, Rifampin
Abstract

BACKGROUND\ud Brucella spp. prosthetic joint infections are infrequently reported in the literature, particularly in returning travellers, and optimal treatment is unknown.\ud \ud METHOD\ud We describe a prosthetic joint infection (PJI) caused by Brucella melitensis in a traveller returning to the UK from Thailand, which we believe to be the first detailed report of brucellosis in a traveller returning from this area. The 23 patients with Brucella-related PJI reported in the literature are summarised, together with our case.\ud \ud RESULTS\ud The diagnosis of Brucella-related PJI is difficult to make; only 30% of blood cultures and 75% of joint aspiration cultures were positive in the reported cases. Culture of intraoperative samples provides the best diagnostic yield. In the absence of radiological evidence of joint loosening, combination antimicrobial therapy alone may be appropriate treatment in the first instance; this was successful in 6/7 [86%] of patients, though small numbers of patients and the likelihood of reporting bias warrant caution in drawing any firm conclusions about optimal treatment. Aerosolisation of synovial fluid during joint aspiration procedures and nosocomial infection has been described.\ud \ud CONCLUSIONS\ud Brucella-related PJI should be considered in the differential of travellers returning from endemic areas with PJI, including Thailand. Personal protective equipment including fit tested filtering face piece-3 (FFP3) mask or equivalent is recommended for personnel carrying out joint aspiration when brucellosis is suspected. Travellers can reduce the risk of brucellosis by avoiding unpasteurised dairy products and animal contact (particularly on farms and abattoirs) in endemic areas and should be counselled regarding these risks as part of their pre-travel assessment.

Published
2016
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5. Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT

Author

Scarborough, Matthew, primary, Li, Ho Kwong, additional, Rombach, Ines, additional, Zambellas, Rhea, additional, Walker, A Sarah, additional, McNally, Martin, additional, Atkins, Bridget, additional, Kümin, Michelle, additional, Lipsky, Benjamin A, additional, Hughes, Harriet, additional, Bose, Deepa, additional, Warren, Simon, additional, Mack, Damien, additional, Folb, Jonathan, additional, Moore, Elinor, additional, Jenkins, Neil, additional, Hopkins, Susan, additional, Seaton, R Andrew, additional, Hemsley, Carolyn, additional, Sandoe, Jonathan, additional, Aggarwal, Ila, additional, Ellis, Simon, additional, Sutherland, Rebecca, additional, Geue, Claudia, additional, McMeekin, Nicola, additional, Scarborough, Claire, additional, Paul, John, additional, Cooke, Graham, additional, Bostock, Jennifer, additional, Khatamzas, Elham, additional, Wong, Nick, additional, Brent, Andrew, additional, Lomas, Jose, additional, Matthews, Philippa, additional, Wangrangsimakul, Tri, additional, Gundle, Roger, additional, Rogers, Mark, additional, Taylor, Adrian, additional, Thwaites, Guy E, additional, and Bejon, Philip, additional

Published
2019
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6. Population-level genomics identifies the emergence and global spread of a human transmissible multidrug-resistant nontuberculous mycobacterium

Author

Bryant, Josephine M, Grogono, Dorothy M, Rodriguez-Rincon, Daniela, Everall, Isobel, Brown, Karen P, Moreno, Pablo, Verma, Deepshikha, Hill, Emily, Drijkoningen, Judith, Gilligan, Peter, Esther, Charles R, Noone, Peadar G, Giddings, Olivia, Bell, Scott C., Thomson, Rachel, Wainwright, Claire E., Coulter, Chris, Pandey, Sushil, Wood, Michelle E, Stockwell, Rebecca E, Ramsay, Kay A, Sherrard, Laura J, Kidd, Timothy J, Jabbour, Nassib, Johnson, Graham R, Knibbs, Luke D, Morawska, Lidia, Sly, Peter D, Jones, Andrew, Bilton, Diana, Laurenson, Ian, Ruddy, Michael, Bourke, Stephen, Bowler, Ian CJW, Chapman, Stephen J, Clayton, Andrew, Cullen, Mairi, Daniels, Thomas, Dempsey, Owen, Denton, Miles, Desai, Maya, Drew, Richard J, Edenborough, Frank, Evans, Jason, Folb, Jonathan, Humphrey, Helen, Isalska, Barbara, Jensen-Fangel, Søren, Jönsson, Bodil, Jones, Andrew M., Katzenstein, Terese L, Lillebaek, Troels, MacGregor, Gordon, Mayell, Sarah, Millar, Michael, Modha, Deborah, Nash, Edward F, O’Brien, Christopher, O’Brien, Deirdre, Ohri, Chandra, Pao, Caroline S, Peckham, Daniel, Perrin, Felicity, Perry, Audrey, Pressler, Tania, Prtak, Laura, Qvist, Tavs, Robb, Ali, Rodgers, Helen, Schaffer, Kirsten, Shafi, Nadia, van Ingen, Jakko, Walshaw, Martin, Watson, Danie, West, Noreen, Whitehouse, Joanna, Haworth, Charles S, Harris, Simon R, Ordway, Diane, Parkhill, Julian, and Floto, R. Andres

Subjects
Cystic Fibrosis, Incidence, Mycobacterium Infections, Nontuberculous, Nontuberculous Mycobacteria, Genomics, Mice, SCID, Sequence Analysis, DNA, bacterial infections and mycoses, Communicable Diseases, Emerging, Polymorphism, Single Nucleotide, Article, Mice, Drug Resistance, Multiple, Bacterial, Pneumonia, Bacterial, bacteria, Animals, Humans, Lung, Genome, Bacterial, Phylogeny
Abstract

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Published
2016

10. Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make ajoint public statement of opposition to the amended section 75 regulations

Author

Davis, Jacky, Banks, Ian, Wrigley, David, Peedell, Clive, Pollock, Alyson, McPherson, Klim, McKee, Martin, Irving, William L, Crome, Peter, Greenhalgh, Trisha, Holland, Walter, Evans, David, Maryon-Davis, Alan, Smyth, Alan, Fleming, Peter, Coleman, Michel, Sharp, Deborah J, Whincup, Peter, Logan, Stuart, Cook, Derek, Moore, Robert, Rawaf, Salman, McEewen, J, West, Robert, Yudkin, John S, Clarke, Aileen, Finer, Nick, Domizio, Paola, Bambra, Clare, Jones, Anna, Feder, Gene, Scott-Samuel, Alex, Irvine, Louise, Sharma, Ajay, Fitchett, Mike, Boomla, Kambiz, Folb, Jonathan, Paul, Ashish, McCoy, David, Tallis, Ray, Burgess-Allen, Jilla, Edwards, Mark, Tomlinson, Jonathon, Colvin, Deborah, Gore, Jonathan, Brown, Kirsten, Mitchel, Sarah, Lau, Alice, Sayer, Mel, Clark, Leon, Silverman, Ruth, Marmot, Saul, Rainbow, Daniel, Carter, Lucy, Mann, Nick, Fielding, Richard, Logan, Jane, Tebboth, Louise, Arnold, Natasha, Stobbart, Kate, Cabot, Kate, Finer, Sarah, Edwards, Martin, Davies, David, Buttivant, Helen, Kraemer, Sebastian, Newell, Jo, Griffiths, Alun, Fitzgerald, Richard, Macgibbon, Robert, Lee, Alan, Macklon, AF, Hobson, Esther, Jenner, David, Jacobson, Bobbie, Timmis, Alison, Salim, Asad, Evans-Jones, John, Caan, Woody, Awsare, Ninaad, Pride, Neil, Suckling, Ruth, Bratty, Catherine, Rossiter, Brian, Hawkins, David, Currie, Jonny, Camilleri-Ferrante, Corinne, Fluxman, Jonathan, Bhatti, Osman, Anson, James, Etherington, Robert, Lawrence, David, Fell, Henry, Clarke, Edward, Ormerod, Julian, Ormerod, Oliver, Ireland, Maggie, Duncan, John AT, Chandy, Rajiv, Mindell, Jennifer, Mullen, Paul, Bennett-Richards, Phillip, Hirst, Julie, Murphy, E, Martin, P, Lowes, Simon, Grunewald, Richard, Reeve, Joanne, Schweiger, Martin, Coates, Jonathan, Farrelly, George, Chamberlain, MA, Lewis, Geoffrey, Young, Jane, Scott, Brian, Gibbs, John, Landers, Aileen, Deveson, Pete, Ingrams, Grant, Leigh, Martha, Gawler, Jeff, Ford, Amy, Nixon, Jonathan, McCartney, Margaret, Bareford, David, Singh, Surinder, Lockwood, Kate, Cripwell, Michael, Ehrhardt, Peter, Bell, David, Wortley, Pam, Tomlinson, Laurie, Hotchkiss, Julie, Ford, Steven, Turner, Gill, Reissman, Gerard, Lewis, David, Johnstone, Chris, Tomson, Mike, Torabi, Payam, Tomson, D, Tulloch, Alex, Johnston, Sally, Dickinson, Jane, McElderry, Elisabeth, Ross, Wendy, Holt, Kim, Logan, Mary, Klonin, Hilary, Danby, Jude, Goodger, V, Puntis, John, Dickson, Harriet, Gould, Derek A, Livingstone, Anna, Lefevre, Dianne, Kendall, Bryony, Singh, G, Hall, Peter, Darling, Jonathan, Hamlyn, Adrian N, Patel, Anita, Erskine, Jonathan, Fisher, Brian, Hughes, Richard, Highton, Clare, Venning, Helen, Singer, Ron, Brearey, Steve, Sikorski, Jim, Paintin, David, Feehally, John, Savage, Wendy, Freud, Kathy McAdam, Holt, Victoria J, Gill, Alison, Waterston, Tony, Souza, Richard de, Hopkinson, Nicholas, Beadsworth, Mike, Franks, Andrea, Daley, Helen, Cullinan, Paul, Basarab, Adriana, Gurling, Hugh, Zinkin, Pam, Kirwin, Simon, Buhrs, Ernst, Brown, Raymond, West, Andrew, Marlowe, Gary, Fellows, Griffith, Main, John, Applebee, Jackie, Koperski, M, Jones, Phil, Macfarlane, Alison, Beer, Naomi, Mason, Rebecca, Eisner, Maggie, Smailes, Alison, Timms, Philip, Knight, David, Jones, Coral, Wesby, Barbara, Lyttelton, Laura, Morrison, Richard, Bossano, David, Walker, Jonathan, Davies, Gerry, Godfrey, Peter, Wolfe, Ingrid, Nsutebu, Emmanuel, Stevenson, Nicola, Cheeroth, Sheila, Miller, Jo, Johnson, Guy, Noor, R, Hall, Alyson, Bostock, David, Michael, Benedict, Sharvill, John, Macpherson, Jamie, Ma, Richard, Middleton, John, Jeffreys, Anne, Cole, Jim, Boswell, John P, Bury, Bob, Mitchison, Sally, Kinmonth, Ann-Louise, Young, Gail, Maclennan, Iain, and Munday, Pat

Subjects
Insurance, Health, Health Care Reform, Managed Competition, Politics, Academies and Institutes, Humans, Dissent and Disputes, Privatization, Societies, Medical, State Medicine, United Kingdom

11. Act now against new NHS competition regulations

Author

Davis, Jacky, Banks, Ian, Wrigley, David, Peedell, Clive, Pollock, Alyson, McPherson, Klim, McKee, Martin, Irving, William L, Crome, Peter, Greenhalgh, Trisha, Holland, Walter, Evans, David, Maryon-Davis, Alan, Smyth, Alan, Fleming, Peter, Coleman, Michel, Sharp, Deborah J, Whincup, Peter, Logan, Stuart, Cook, Derek, Moore, Robert, Rawaf, Salman, McEewen, J, West, Robert, Yudkin, John S, Clarke, Aileen, Finer, Nick, Domizio, Paola, Bambra, Clare, Jones, Anna, Feder, Gene, Scott-Samuel, Alex, Irvine, Louise, Sharma, Ajay, Fitchett, Mike, Boomla, Kambiz, Folb, Jonathan, Paul, Ashish, McCoy, David, Tallis, Ray, Burgess-Allen, Jilla, Edwards, Mark, Tomlinson, Jonathon, Colvin, Deborah, Gore, Jonathan, Brown, Kirsten, Mitchel, Sarah, Lau, Alice, Sayer, Mel, Clark, Leon, Silverman, Ruth, Marmot, Saul, Rainbow, Daniel, Carter, Lucy, Mann, Nick, Fielding, Richard, Logan, Jane, Tebboth, Louise, Arnold, Natasha, Stobbart, Kate, Cabot, Kate, Finer, Sarah, Edwards, Martin, Davies, David, Buttivant, Helen, Kraemer, Sebastian, Newell, Jo, Griffiths, Alun, FitzGerald, Richard, MacGibbon, Robert, Lee, Alan, Macklon, A F, Hobson, Esther, Jenner, David, Jacobson, Bobbie, Timmis, Alison, Salim, Asad, Evans-Jones, John, Caan, Woody, Awsare, Ninaad, Pride, Neil, Suckling, Ruth, Bratty, Catherine, Rossiter, Brian, Hawkins, David, Currie, Jonny, Camilleri-Ferrante, Corinne, Fluxman, Jonathan, Bhatti, Osman, Anson, James, Etherington, Robert, Lawrence, David, Fell, Henry, Clarke, Edward, Ormerod, Julian, Ormerod, Oliver, Ireland, Maggie, Duncan, John A T, Chandy, Rajiv, Mindell, Jennifer, Mullen, Paul, Bennett-Richards, Phillip, Hirst, Julie, Murphy, E, Martin, P, Lowes, Simon, Fleming, Peter, Grunewald, Richard, Reeve, Joanne, Schweiger, Martin, Coates, Jonathan, Farrelly, George, Chamberlain, M A, Lewis, Geoffrey, Young, Jane, Scott, Brian, Gibbs, John, Landers, Aileen, Deveson, Pete, Ingrams, Grant, Leigh, Martha, Gawler, Jeff, Ford, Amy, Nixon, Jonathan, McCartney, Margaret, Bareford, David, Singh, Surinder, Lockwood, Kate, Cripwell, Michael, Ehrhardt, Peter, Bell, David, Wortley, Pam, Tomlinson, Laurie, Hotchkiss, Julie, Ford, Steven, Turner, Gill, Reissman, Gerard, Lewis, David, Johnstone, Chris, Tomson, Mike, Torabi, Payam, Bell, David, Tomson, D, Tulloch, Alex, Johnston, Sally, Dickinson, Jane, McElderry, Elisabeth, Ross, Wendy, Holt, Kim, Logan, Mary, Klonin, Hilary, Jenner, David, Danby, Jude, Goodger, V, Puntis, John, Dickson, Harriet, Gould, Derek A, Livingstone, Anna, Lefevre, Dianne, Kendall, Bryony, Singh, G, Hall, Peter, Darling, Jonathan, Hamlyn, Adrian N, Patel, Anita, Erskine, Jonathan, Fisher, Brian, Hughes, Richard, Highton, Clare, Venning, Helen, Singer, Ron, Brearey, Steve, Sikorski, Jim, Paintin, David, Feehally, John, Savage, Wendy, Freud, Kathy McAdam, Holt, Victoria J, Gill, Alison, Waterston, Tony, Souza, Richard de, Hopkinson, Nicholas, Beadsworth, Mike, Franks, Andrea, Daley, Helen, Cullinan, Paul, Basarab, Adriana, Folb, Jonathan, Gurling, Hugh, Zinkin, Pam, Kirwin, Simon, Buhrs, Ernst, Brown, Raymond, West, Andrew, Marlowe, Gary, Fellows, Griffith, Main, John, Applebee, Jackie, Koperski, M, Jones, Phil, Macfarlane, Alison, Beer, Naomi, Mason, Rebecca, West, Robert, Eisner, Maggie, Smailes, Alison, Timms, Philip, Knight, David, Jones, Coral, Wesby, Barbara, Lyttelton, Laura, Morrison, Richard, Bossano, David, Walker, Jonathan, Davies, Gerry, Godfrey, Peter, Wolfe, Ingrid, Nsutebu, Emmanuel, Stevenson, Nicola, Cheeroth, Sheila, Miller, Jo, Johnson, Guy, Noor, R, Hall, Alyson, Bostock, David, Michael, Benedict, Sharvill, John, Macpherson, Jamie, Lewis, David, Ma, Richard, Middleton, John, Jeffreys, Anne, Cole, Jim, Boswell, John P, Bury, Bob, Mitchison, Sally, Kinmonth, Ann-Louise, Young, Gail, Maclennan, Iain, and Munday, Pat

Published
2013
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12. Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.

Author

Davis J, Banks I, Wrigley D, Peedell C, Pollock A, McPherson K, McKee M, Irving WL, Crome P, Greenhalgh T, Holland W, Evans D, Maryon-Davis A, Smyth A, Fleming P, Coleman M, Sharp DJ, Whincup P, Logan S, Cook D, Moore R, Rawaf S, McEewen J, West R, Yudkin JS, Clarke A, Finer N, Domizio P, Bambra C, Jones A, Feder G, Scott-Samuel A, Irvine L, Sharma A, Fitchett M, Boomla K, Folb J, Paul A, McCoy D, Tallis R, Burgess-Allen J, Edwards M, Tomlinson J, Colvin D, Gore J, Brown K, Mitchel S, Lau A, Sayer M, Clark L, Silverman R, Marmot S, Rainbow D, Carter L, Mann N, Fielding R, Logan J, Tebboth L, Arnold N, Stobbart K, Cabot K, Finer S, Edwards M, Davies D, Buttivant H, Kraemer S, Newell J, Griffiths A, Fitzgerald R, Macgibbon R, Lee A, Macklon AF, Hobson E, Jenner D, Jacobson B, Timmis A, Salim A, Evans-Jones J, Caan W, Awsare N, Pride N, Suckling R, Bratty C, Rossiter B, Hawkins D, Currie J, Camilleri-Ferrante C, Fluxman J, Bhatti O, Anson J, Etherington R, Lawrence D, Fell H, Clarke E, Ormerod J, Ormerod O, Ireland M, Duncan JA, Chandy R, Mindell J, Mullen P, Bennett-Richards P, Hirst J, Murphy E, Martin P, Lowes S, Fleming P, Grunewald R, Reeve J, Schweiger M, Coates J, Farrelly G, Chamberlain MA, Lewis G, Young J, Scott B, Gibbs J, Landers A, Deveson P, Ingrams G, Leigh M, Gawler J, Ford A, Nixon J, McCartney M, Bareford D, Singh S, Lockwood K, Cripwell M, Ehrhardt P, Bell D, Wortley P, Tomlinson L, Hotchkiss J, Ford S, Turner G, Reissman G, Lewis D, Johnstone C, Tomson M, Torabi P, Bell D, Tomson D, Tulloch A, Johnston S, Dickinson J, McElderry E, Ross W, Holt K, Logan M, Klonin H, Jenner D, Danby J, Goodger V, Puntis J, Dickson H, Gould DA, Livingstone A, Lefevre D, Kendall B, Singh G, Hall P, Darling J, Hamlyn AN, Patel A, Erskine J, Fisher B, Hughes R, Highton C, Venning H, Singer R, Brearey S, Sikorski J, Paintin D, Feehally J, Savage W, Freud KM, Holt VJ, Gill A, Waterston T, Souza Rd, Hopkinson N, Beadsworth M, Franks A, Daley H, Cullinan P, Basarab A, Folb J, Gurling H, Zinkin P, Kirwin S, Buhrs E, Brown R, West A, Marlowe G, Fellows G, Main J, Applebee J, Koperski M, Jones P, Macfarlane A, Beer N, Mason R, West R, Eisner M, Smailes A, Timms P, Knight D, Jones C, Wesby B, Lyttelton L, Morrison R, Bossano D, Walker J, Davies G, Godfrey P, Wolfe I, Nsutebu E, Stevenson N, Cheeroth S, Miller J, Johnson G, Noor R, Hall A, Bostock D, Michael B, Sharvill J, Macpherson J, Lewis D, Ma R, Middleton J, Jeffreys A, Cole J, Boswell JP, Bury B, Mitchison S, Kinmonth AL, Young G, Maclennan I, and Munday P

Subjects
Academies and Institutes, Health Care Reform legislation & jurisprudence, Humans, Insurance, Health, Managed Competition legislation & jurisprudence, Politics, United Kingdom, Dissent and Disputes legislation & jurisprudence, Health Care Reform organization & administration, Managed Competition organization & administration, Privatization, Societies, Medical, State Medicine legislation & jurisprudence, State Medicine organization & administration
Published
2013
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