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2. Application of CRISS score, revised CRISS score and RCID score in patients with Juvenile systemic sclerosis

Author

Klotsche, J, Foeldvari, I, Torok, K, Del Gado, F, Furst, DE, Kasapcopur, O, Adrovic, A, Feldman, B, Terreri, MT, Sakamoto, AP, Sztajnbok, F, Anton, J, Katsicas, M, Stanevicha, V, Appenzeller, S, Avcin, T, Johnson, S, Kostik, M, Malcova, H, Marrani, E, Sifuentes-Giraldo, WA, Khubchandani, R, Nemcova, D, Santos, MJ, Schonenberg, D, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Eleftheriou, D, Harel, L, Horneff, G, Kallinich, T, Lehman, T, Minden, K, Moll, M, Nielsen, S, Patwardhan, A, Smith, V, Helmus, N, Klotsche, J, Foeldvari, I, Torok, K, Del Gado, F, Furst, DE, Kasapcopur, O, Adrovic, A, Feldman, B, Terreri, MT, Sakamoto, AP, Sztajnbok, F, Anton, J, Katsicas, M, Stanevicha, V, Appenzeller, S, Avcin, T, Johnson, S, Kostik, M, Malcova, H, Marrani, E, Sifuentes-Giraldo, WA, Khubchandani, R, Nemcova, D, Santos, MJ, Schonenberg, D, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Eleftheriou, D, Harel, L, Horneff, G, Kallinich, T, Lehman, T, Minden, K, Moll, M, Nielsen, S, Patwardhan, A, Smith, V, and Helmus, N

Published
2023

3. Entwicklung und psychometrische Validierung eines Selbsterhebungs-Instrumentes zur übergreifenden Erfassung von Kompetenzen, ungedeckten Bedarfen und der Zufriedenheit im Transitionsprozess

Author

Haney, H, Niewerth, M, Klotsche, J, Schalm, S, Hoff, P, Tatsis, S, Foeldvari, I, Kötter, I, Seipelt, E, Erbis, G, Hansmann, S, Reiser, C, Saur, SJ, Schua, S, Hardt, S, Ratanski, M, Maier, A, Minden, K, Haney, H, Niewerth, M, Klotsche, J, Schalm, S, Hoff, P, Tatsis, S, Foeldvari, I, Kötter, I, Seipelt, E, Erbis, G, Hansmann, S, Reiser, C, Saur, SJ, Schua, S, Hardt, S, Ratanski, M, Maier, A, and Minden, K

Published
2023

4. Versorgungssituation junger Rheumatiker mit chronischen Arthritiden - eine bevölkerungsbezogene Umfrage

Author

Minden, K, Marschall, U, Liedmann, I, Niewerth, M, Reiser, C, Tatsis, S, Foeldvari, I, Erbis, G, Seipelt, E, Hansmann, S, Maier, A, Ratanski, M, Schua, S, Brunner, J, Mrusek, S, Kötter, I, Schalm, S, Minden, K, Marschall, U, Liedmann, I, Niewerth, M, Reiser, C, Tatsis, S, Foeldvari, I, Erbis, G, Seipelt, E, Hansmann, S, Maier, A, Ratanski, M, Schua, S, Brunner, J, Mrusek, S, Kötter, I, and Schalm, S

Published
2023

5. 24-Monats-Daten zu Wirksamkeit und Sicherheit von Tocilizumab im Vergleich zu TNF Inhibitoren bei polyartikulärer juveniler idiopathischer Arthritis

Author

Horneff, G, Zimmer, A, Hufnagel, M, Hospach, A, Weller-Heinemann, F, Kümmerle-Deschner, JB, Hansmann, S, Fasshauer, M, Minden, K, Foeldvari, I, Windschall, D, Föll, D, Oommen, PT, Klein, A, Horneff, G, Zimmer, A, Hufnagel, M, Hospach, A, Weller-Heinemann, F, Kümmerle-Deschner, JB, Hansmann, S, Fasshauer, M, Minden, K, Foeldvari, I, Windschall, D, Föll, D, Oommen, PT, and Klein, A

Published
2023

6. Patient and physician reported outcomes of juvenile systemic sclerosis patients significantly improve over 24 months observation period in the juvenile systemic scleroderma inception cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Anton, J, Feldman, B, Khubchandani, R, Kostik, M, Lehman, T, Marrani, E, Katsicas, M, Nemcova, D, Santos, MJ, Sztajnbok, F, Appenzeller, S, Battagliotti, C, Berntson, L, Brunner, J, Harel, L, Horneff, G, Johnson, S, Kallinich, T, Minden, K, Moll, M, Nuruzzaman, F, Patwardhan, A, Schonenberg, D, Helmus, N, Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Anton, J, Feldman, B, Khubchandani, R, Kostik, M, Lehman, T, Marrani, E, Katsicas, M, Nemcova, D, Santos, MJ, Sztajnbok, F, Appenzeller, S, Battagliotti, C, Berntson, L, Brunner, J, Harel, L, Horneff, G, Johnson, S, Kallinich, T, Minden, K, Moll, M, Nuruzzaman, F, Patwardhan, A, Schonenberg, D, and Helmus, N

Published
2023

7. Elternberichtete-Outcomes und Therapiezufriedenheit im ersten Behandlungsjahr bei JIA, SLE und JDM - Interimsergebnisse aus ProKind-Rheuma

Author

Minden, K, Trauzeddel, R, Tenbrock, K, Horneff, G, Brück, N, Vollbach, K, Klaas, M, Foeldvari, I, Klein, A, Hufnagel, M, Kümmerle-Deschner, J, Haas, JP, Kallinich, T, Rietschel, C, Föll, D, Hospach, A, Klotsche, J, Mönkemöller, K, Mrusek, S, Oommen, PT, Rühlmann, M, Windschall, D, Weller-Heinemann, F, Schütz, C, Brunner, J, Minden, K, Trauzeddel, R, Tenbrock, K, Horneff, G, Brück, N, Vollbach, K, Klaas, M, Foeldvari, I, Klein, A, Hufnagel, M, Kümmerle-Deschner, J, Haas, JP, Kallinich, T, Rietschel, C, Föll, D, Hospach, A, Klotsche, J, Mönkemöller, K, Mrusek, S, Oommen, PT, Rühlmann, M, Windschall, D, Weller-Heinemann, F, Schütz, C, and Brunner, J

Published
2023

8. Langzeitwirksamkeit von Canakinumab bei autoinflammatorischen periodischen Syndromen - Interimsanalyse des RELIANCE-Registers

Author

Kallinich, T, Blank, N, Henes, J, Kortus-Götze, B, Oommen, PT, Pankow, A, Krickau, T, Schütz, C, Horneff, G, Foeldvari, I, Rech, J, Weller-Heinemann, F, Janda, A, Hufnagel, M, Meier, F, Dressler, F, Borte, M, Andreica, I, Wasiliew, P, Fiene, M, Windschall, D, Weber-Arden, J, Kümmerle-Deschner, JB, Kallinich, T, Blank, N, Henes, J, Kortus-Götze, B, Oommen, PT, Pankow, A, Krickau, T, Schütz, C, Horneff, G, Foeldvari, I, Rech, J, Weller-Heinemann, F, Janda, A, Hufnagel, M, Meier, F, Dressler, F, Borte, M, Andreica, I, Wasiliew, P, Fiene, M, Windschall, D, Weber-Arden, J, and Kümmerle-Deschner, JB

Published
2023

9. Führt die Langzeitbehandlung mit Canakinumab bei autoinflammatorischen periodischen Fiebersyndromen vermehrt zu Infektionen? 48-Monats-Daten des RELIANCE-Registers

Author

Kümmerle-Deschner, JB, Henes, J, Kortus-Götze, B, Oommen, PT, Pankow, A, Kallinich, T, Krickau, T, Schütz, C, Horneff, G, Foeldvari, I, Rech, J, Weller-Heinemann, F, Janda, A, Hufnagel, M, Meier, F, Dressler, F, Borte, M, Andreica, I, Wasiliew, P, Fiene, M, Windschall, D, Weber-Arden, J, Blank, N, Kümmerle-Deschner, JB, Henes, J, Kortus-Götze, B, Oommen, PT, Pankow, A, Kallinich, T, Krickau, T, Schütz, C, Horneff, G, Foeldvari, I, Rech, J, Weller-Heinemann, F, Janda, A, Hufnagel, M, Meier, F, Dressler, F, Borte, M, Andreica, I, Wasiliew, P, Fiene, M, Windschall, D, Weber-Arden, J, and Blank, N

Published
2023

10. Diffuse juvenile systemic sclerosis patients show distinct organ involvement, antibody pattern and have significantly more severe disease in the largest jSSc cohort of the world. Results from the juvenile scleroderma inception cohort

Author

Foeldvari, I, Klotsche, J, Torok, K, Kasapcopur, O, Adrovic, A, Terreri, MT, Sakamoto, AP, Feldman, B, Sztajnbok, F, Anton, J, Stanevicha, V, Johnson, S, Khubchandani, R, Schonenberg, D, Al-Abadi, E, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Malcova, H, Marrani, E, Pain, C, Patwardhan, A, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Costa Reis, P, Janarthanan, M, Nemcova, D, Santos, MJ, Abu Al-Saoud, S, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nielsen, S, Nuruzzaman, F, Opsahl Hetlevik, S, Uziel, Y, Helmus, N, Foeldvari, I, Klotsche, J, Torok, K, Kasapcopur, O, Adrovic, A, Terreri, MT, Sakamoto, AP, Feldman, B, Sztajnbok, F, Anton, J, Stanevicha, V, Johnson, S, Khubchandani, R, Schonenberg, D, Al-Abadi, E, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Malcova, H, Marrani, E, Pain, C, Patwardhan, A, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Costa Reis, P, Janarthanan, M, Nemcova, D, Santos, MJ, Abu Al-Saoud, S, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nielsen, S, Nuruzzaman, F, Opsahl Hetlevik, S, Uziel, Y, and Helmus, N

Published
2023

11. Is decreased body mass index-2 z score or less correlating with an organ involvement pattern? Results from the juvenile scleroderma inception cohort

Author

Foeldvari, I, Klotsche, J, Torok, K, Kasapcopur, O, Adrovic, A, Feldman, B, Sztajnbok, F, Anton, J, Terreri, MT, Sakamoto, AP, Khubchandani, R, Stanevicha, V, Al-Abadi, E, Alexeeva, E, Katsicas, M, Sawhney, S, Schonenberg, D, Smith, V, Appenzeller, S, Avcin, T, Lehman, T, Malcova, H, Marrani, E, Patwardhan, A, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Costa Reis, P, Janarthanan, M, Johnson, S, Kostik, M, Nemcova, D, Pain, C, Santos, MJ, Abu Al-Saoud, S, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nuruzzaman, F, Opsahl Hetlevik, S, Uziel, Y, Helmus, N, Foeldvari, I, Klotsche, J, Torok, K, Kasapcopur, O, Adrovic, A, Feldman, B, Sztajnbok, F, Anton, J, Terreri, MT, Sakamoto, AP, Khubchandani, R, Stanevicha, V, Al-Abadi, E, Alexeeva, E, Katsicas, M, Sawhney, S, Schonenberg, D, Smith, V, Appenzeller, S, Avcin, T, Lehman, T, Malcova, H, Marrani, E, Patwardhan, A, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Costa Reis, P, Janarthanan, M, Johnson, S, Kostik, M, Nemcova, D, Pain, C, Santos, MJ, Abu Al-Saoud, S, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nuruzzaman, F, Opsahl Hetlevik, S, Uziel, Y, and Helmus, N

Published
2023

12. Auswirkungen der Coronavirus-Pandemie auf Patienten mit autoinflammatorischen periodischen Syndromen unter Canakinumab-Behandlung - Interimsergebnisse aus dem RELIANCE-Register

Author

Blank, N, Kümmerle-Deschner, JB, Henes, J, Kortus-Götze, B, Oommen, PT, Pankow, A, Krickau, T, Schütz, C, Horneff, G, Foeldvari, I, Rech, J, Weller-Heinemann, F, Janda, A, Hufnagel, M, Meier, F, Dressler, F, Borte, M, Andreica, I, Wasiliew, P, Fiene, M, Windschall, D, Weber-Arden, J, Kallinich, T, Blank, N, Kümmerle-Deschner, JB, Henes, J, Kortus-Götze, B, Oommen, PT, Pankow, A, Krickau, T, Schütz, C, Horneff, G, Foeldvari, I, Rech, J, Weller-Heinemann, F, Janda, A, Hufnagel, M, Meier, F, Dressler, F, Borte, M, Andreica, I, Wasiliew, P, Fiene, M, Windschall, D, Weber-Arden, J, and Kallinich, T

Published
2023

13. Prävalenz und Korrelate von Angst- und Depressionssymptomen bei Jugendlichen und jungen Erwachsenen mit juveniler idiopathischer Arthritis (JIA): Ergebnisse aus COACH

Author

Milatz, F, Niewerth, M, Tomuscheit, J, Sengler, C, Grösch, N, Klotsche, J, Windschall, D, Kallinich, T, Dressler, F, Trauzeddel, R, Holl, RW, Foeldvari, I, Brück, N, Temming, S, Hospach, A, Warschburger, P, Berendes, R, Kümmerle-Deschner, J, Weller-Heinemann, F, Haas, JP, Müller-Stierlin, AS, Mutter, A, Meissner, T, Baumeister, H, Minden, K, Milatz, F, Niewerth, M, Tomuscheit, J, Sengler, C, Grösch, N, Klotsche, J, Windschall, D, Kallinich, T, Dressler, F, Trauzeddel, R, Holl, RW, Foeldvari, I, Brück, N, Temming, S, Hospach, A, Warschburger, P, Berendes, R, Kümmerle-Deschner, J, Weller-Heinemann, F, Haas, JP, Müller-Stierlin, AS, Mutter, A, Meissner, T, Baumeister, H, and Minden, K

Published
2023

15. Diffuse juvenile systemic sclerosis patients show distinct organ involvement and have more severe disease in the largest jSSc cohort of the world. Results from the the juvenile scleroderma inception cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Sztajnbok, F, Stanevicha, V, Anton, J, Johnson, S, Khubchandani, R, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Malcova, H, Marrani, E, Pain, C, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Costa Reis, P, Janarthanan, M, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Abu Al-Saoud, S, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Cimaz, R, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nuruzzaman, F, Opsahl Hetlevik, S, Uziel, Y, Helmus, N, Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Sztajnbok, F, Stanevicha, V, Anton, J, Johnson, S, Khubchandani, R, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Malcova, H, Marrani, E, Pain, C, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Costa Reis, P, Janarthanan, M, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Abu Al-Saoud, S, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Cimaz, R, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nuruzzaman, F, Opsahl Hetlevik, S, Uziel, Y, and Helmus, N

Published
2022

16. Depressive und ängstliche Symptome bei Patienten mit juveniler idiopathischer Arthritis (JIA) - Daten aus der Inzeptionskohorte neu diagnostizierter Kinder und Jugendlicher mit JIA (ICON)

Author

Sengler, C, Oommen, P, Klotsche, J, Berendes, R, Dressler, F, Foeldvari, I, Föll, D, Geikowski, T, Haller, M, Horneff, G, Hospach, A, Kallinich, T, Kümmerle-Deschner, J, Liedmann, I, Mönkemöller, K, Niewerth, M, Rühlmann, M, Schmalbach, T, Siemer, C, Weller-Heinemann, F, Windschall, D, Minden, K, Sengler, C, Oommen, P, Klotsche, J, Berendes, R, Dressler, F, Foeldvari, I, Föll, D, Geikowski, T, Haller, M, Horneff, G, Hospach, A, Kallinich, T, Kümmerle-Deschner, J, Liedmann, I, Mönkemöller, K, Niewerth, M, Rühlmann, M, Schmalbach, T, Siemer, C, Weller-Heinemann, F, Windschall, D, and Minden, K

Published
2022

17. Juvenile systemic sclerosis treatment practices in an international cohort and comparison to recent SHARE consensus guidelines

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Anton, J, Sztajnbok, F, Stanevicha, V, Appenzeller, S, Avcin, T, Johnson, S, Khubchandani, R, Kostik, M, Marrani, E, Sifuentes-Giraldo, WA, Nemcova, D, Santos, MJ, Schonenberg, D, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Cimaz, R, Eleftheriou, D, Harel, L, Horneff, G, Janarthanan, M, Kallinich, T, Lehman, T, Moll, M, Nuruzzaman, F, Patwardhan, A, Smith, V, Helmus, N, Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Anton, J, Sztajnbok, F, Stanevicha, V, Appenzeller, S, Avcin, T, Johnson, S, Khubchandani, R, Kostik, M, Marrani, E, Sifuentes-Giraldo, WA, Nemcova, D, Santos, MJ, Schonenberg, D, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Cimaz, R, Eleftheriou, D, Harel, L, Horneff, G, Janarthanan, M, Kallinich, T, Lehman, T, Moll, M, Nuruzzaman, F, Patwardhan, A, Smith, V, and Helmus, N

Published
2022

18. Behandlung und Outcomes neu diagnostizierter Patient:innen mit polyartikulärer juveniler idiopathischer Arthritis (pJIA) - erste Ergebnisse aus ProKind-Rheuma

Author

Vollbach, K, Eulert, S, Tenbrock, K, Klotsche, J, Foell, D, Haas, JP, Weller-Heinemann, F, Mrusek, S, Oommen, PT, Windschall, D, Mönkemöller, K, Kallinich, T, Hufnagel, M, Foeldvari, I, Hospach, A, Klaas, M, Rühlmann, M, Trauzeddel, R, Brück, N, Schütz, C, Kümmerle Deschner, J, Klein, A, Minden, K, Horneff, G, Vollbach, K, Eulert, S, Tenbrock, K, Klotsche, J, Foell, D, Haas, JP, Weller-Heinemann, F, Mrusek, S, Oommen, PT, Windschall, D, Mönkemöller, K, Kallinich, T, Hufnagel, M, Foeldvari, I, Hospach, A, Klaas, M, Rühlmann, M, Trauzeddel, R, Brück, N, Schütz, C, Kümmerle Deschner, J, Klein, A, Minden, K, and Horneff, G

Published
2022

19. Wirksamkeit und Sicherheit von IL-6-Inhibition (Tocilizumab) im Vergleich zu TNF-Inhibition bei polyartikulärer juveniler idiopathischer Arthritis: Ergebnisse aus dem BIKER-Register

Author

Klein, A, Zimmer, A, Hospach, A, Weller-Heinemann, F, Hansmann, S, Kuemmerle Deschner, J, Fasshauer, M, Minden, K, Foeldvari, I, Rietschel, C, Windschall, D, Ralf, T, Hufnagel, M, Foell, D, Berende, R, Oommen, P, Böschow, G, Dressler, F, Horneff, G, Klein, A, Zimmer, A, Hospach, A, Weller-Heinemann, F, Hansmann, S, Kuemmerle Deschner, J, Fasshauer, M, Minden, K, Foeldvari, I, Rietschel, C, Windschall, D, Ralf, T, Hufnagel, M, Foell, D, Berende, R, Oommen, P, Böschow, G, Dressler, F, and Horneff, G

Published
2022

20. Patient and physician reported outcomes of juvenile systemic sclerosis patients significantly improve over 12 months observation period in the juvenile systemic scleroderma inception cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Feldman, B, Anton, J, Katsicas, M, Stanevicha, V, Sztajnbok, F, Appenzeller, S, Avcin, T, Kostik, M, Marrani, E, Sifuentes-Giraldo, WA, Johnson, S, Khubchandani, R, Nemcova, D, Santos, MJ, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Cimaz, R, Eleftheriou, D, Harel, L, Horneff, G, Janarthanan, M, Kallinich, T, Minden, K, Moll, M, Nielsen, S, Patwardhan, A, Schonenberg, D, Smith, V, Helmus, N, Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Feldman, B, Anton, J, Katsicas, M, Stanevicha, V, Sztajnbok, F, Appenzeller, S, Avcin, T, Kostik, M, Marrani, E, Sifuentes-Giraldo, WA, Johnson, S, Khubchandani, R, Nemcova, D, Santos, MJ, Battagliotti, C, Berntson, L, Bica, B, Brunner, J, Cimaz, R, Eleftheriou, D, Harel, L, Horneff, G, Janarthanan, M, Kallinich, T, Minden, K, Moll, M, Nielsen, S, Patwardhan, A, Schonenberg, D, Smith, V, and Helmus, N

Published
2022

21. Clinical characteristics of juvenile onset systemic sclerosis patients from the juvenile scleroderma inception cohort compared to adult age juvenile-onset patients from EUSTAR. Are these differences suggesting risk for mortality?

Author

Foeldvari, I, Klotsche, J, Carreira, PE, Kasapcopur, O, Adrovic, A, Torok, K, Airò, P, Iannone, F, Allanore, Y, Balbir-Gurman, A, Schmeiser, T, Sztajnbok, F, Terreri, MT, Stanevicha, V, Anton, J, Feldman, B, Khubchandani, R, Alexeeva, E, Johnson, S, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Campochiaro, C, De Vries-Bouwstra, J, Kostik, M, Lehman, T, Marrani, E, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Malcova, H, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Seskute, G, Truchetet, ME, Veale, D, Hoffmann-Vold, AM, Gabrielli, A, Distler, O, Foeldvari, I, Klotsche, J, Carreira, PE, Kasapcopur, O, Adrovic, A, Torok, K, Airò, P, Iannone, F, Allanore, Y, Balbir-Gurman, A, Schmeiser, T, Sztajnbok, F, Terreri, MT, Stanevicha, V, Anton, J, Feldman, B, Khubchandani, R, Alexeeva, E, Johnson, S, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Campochiaro, C, De Vries-Bouwstra, J, Kostik, M, Lehman, T, Marrani, E, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Malcova, H, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Seskute, G, Truchetet, ME, Veale, D, Hoffmann-Vold, AM, Gabrielli, A, and Distler, O

Published
2022

23. Verlauf der Uveitis bei Kindern mit juveniler idiopathischer Arthritis: Daten aus der Inzeptionskohorte ICON-JIA

Author

Klotsche, J, Sengler, C, Foell, D, Foeldvari, I, Haas, JP, Horneff, G, Dressler, F, Hospach, A, Kallinich, T, Liedmann, I, Mönkemöller, K, Niewerth, M, Weller-Heinemann, F, Windschall, D, Heiligenhaus, A, Minden, K, Baquet-Walscheid, K, Klotsche, J, Sengler, C, Foell, D, Foeldvari, I, Haas, JP, Horneff, G, Dressler, F, Hospach, A, Kallinich, T, Liedmann, I, Mönkemöller, K, Niewerth, M, Weller-Heinemann, F, Windschall, D, Heiligenhaus, A, Minden, K, and Baquet-Walscheid, K

Published
2022

24. Impfsicherheit unter Canakinumab bei Patienten mit autoinflammatorischen periodischen Syndromen - Interimsanalyse des RELIANCE-Registers

Author

Kümmerle-Deschner, JB, Henes, J, Kortus-Götze, B, Kallinich, T, Oommen, PT, Rech, J, Krickau, T, Weller-Heinemann, F, Horneff, G, Janda, A, Foeldvari, I, Meier, F, Schütz, C, Dressler, F, Borte, M, Hufnagel, M, Fiene, M, Weber-Arden, J, Blank, N, Kümmerle-Deschner, JB, Henes, J, Kortus-Götze, B, Kallinich, T, Oommen, PT, Rech, J, Krickau, T, Weller-Heinemann, F, Horneff, G, Janda, A, Foeldvari, I, Meier, F, Schütz, C, Dressler, F, Borte, M, Hufnagel, M, Fiene, M, Weber-Arden, J, and Blank, N

Published
2022

25. Gesundheitsbezogene Transitionskompetenz bei Jugendlichen und jungen Erwachsenen mit juveniler idiopathischer Arthritis (JIA)

Author

Niewerth, M, Minden, K, Schalm, S, Foeldvari, I, Dollinger, S, Horneff, G, Windschall, D, Kallinich, T, Dressler, F, Weller-Heinemann, F, Berendes, R, Hospach, T, Hufnagel, M, Haller, M, Hansmann, S, Klotsche, J, Niewerth, M, Minden, K, Schalm, S, Foeldvari, I, Dollinger, S, Horneff, G, Windschall, D, Kallinich, T, Dressler, F, Weller-Heinemann, F, Berendes, R, Hospach, T, Hufnagel, M, Haller, M, Hansmann, S, and Klotsche, J

Published
2022

26. Langzeitsicherheit und Wirksamkeit von Canakinumab bei Cryopyrin-assoziierten periodischen Syndromen (CAPS) - 36-Monats-Daten aus dem RELIANCE-Register

Author

Kümmerle-Deschner, JB, Kortus-Götze, B, Oommen, PT, Janda, A, Rech, J, Schütz, C, Kallinich, T, Weller-Heinemann, F, Horneff, G, Foeldvari, I, Meier, F, Borte, M, Krickau, T, Weber-Arden, J, Blank, N, Kümmerle-Deschner, JB, Kortus-Götze, B, Oommen, PT, Janda, A, Rech, J, Schütz, C, Kallinich, T, Weller-Heinemann, F, Horneff, G, Foeldvari, I, Meier, F, Borte, M, Krickau, T, Weber-Arden, J, and Blank, N

Published
2022

27. Langzeitwirksamkeit und Sicherheit von Canakinumab bei Patienten mit familiärem Mittelmeerfieber (FMF) - Zwischenanalyse des RELIANCE-Registers

Author

Henes, J, Kümmerle-Deschner, JB, Krickau, T, Kallinich, T, Dressler, F, Horneff, G, Meier, F, Foeldvari, I, Weller-Heinemann, F, Kortus-Götze, B, Hufnagel, M, Rech, J, Oommen, PT, Weber-Arden, J, Blank, N, Henes, J, Kümmerle-Deschner, JB, Krickau, T, Kallinich, T, Dressler, F, Horneff, G, Meier, F, Foeldvari, I, Weller-Heinemann, F, Kortus-Götze, B, Hufnagel, M, Rech, J, Oommen, PT, Weber-Arden, J, and Blank, N

Published
2022

28. A STANDARDIZED ASSESSMENT OF TREATMENT AND OUTCOME OF NEWLY DIAGNOSED PATIENTS WITH JIA WITHIN THE PROKIND PROJECT - PATHWAYS FOR POLYARTICULAR JIA

Author

Eulert, S., Vollbach, K., Tenbrock, K., Klotsche, J., Foell, D., Haas, J. P., Weller-Heinemann, F., Mrusek, S., Oommen, P., Windschall, D., Moenkemoeller, K., Kallinich, T., Hufnagel, M., Foeldvari, I., Hospach, T., Klaas, M., Ruhlmann, M., Trauzeddel, R., Brueck, N., Schutz, C., Kuemmerle-Deschner, J. B., Klein, A., Minden, K., Horneff, G., Eulert, S., Vollbach, K., Tenbrock, K., Klotsche, J., Foell, D., Haas, J. P., Weller-Heinemann, F., Mrusek, S., Oommen, P., Windschall, D., Moenkemoeller, K., Kallinich, T., Hufnagel, M., Foeldvari, I., Hospach, T., Klaas, M., Ruhlmann, M., Trauzeddel, R., Brueck, N., Schutz, C., Kuemmerle-Deschner, J. B., Klein, A., Minden, K., and Horneff, G.

Published
2022

29. TRANSITION COMPETENCE IN YOUNG PEOPLE WITH JUVENILE IDIOPATHIC ARTHRITIS HAS IMPROVED OVER TIME

Author

Minden, K., Niewerth, M., Schalm, S., Foeldvari, I., Haas, J. P., Horneff, G., Windschall, D., Kallinich, T., Dressler, F., Weller-Heinemann, F., Berendes, R., Hospach, T., Hufnagel, M., Haller, M., Hansmann, S., Klotsche, J., Minden, K., Niewerth, M., Schalm, S., Foeldvari, I., Haas, J. P., Horneff, G., Windschall, D., Kallinich, T., Dressler, F., Weller-Heinemann, F., Berendes, R., Hospach, T., Hufnagel, M., Haller, M., Hansmann, S., and Klotsche, J.

Published
2022

30. EFFECTIVENESS AND SAFETY OF IL-6 INHIBITION (TOCILIZUMAB) VERSUS TUMOUR NECROSIS FACTOR INHIBITION IN POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS: RESULTS FROM THE OBSERVATIONAL BIKER STUDY

Author

Klein, A., Zimmer, A., Hospach, T., Weller-Heinemann, F., Hansmann, S., Kuemmerle-Deschner, J., Fasshauer, M., Minden, K., Foeldvari, I., Rietschel, C., Windschall, D., Trauzeddel, R., Hufnagel, M., Foell, D., Berendes, R., Boeschow, G., Oommen, P., Dressler, F., Horneff, G., Klein, A., Zimmer, A., Hospach, T., Weller-Heinemann, F., Hansmann, S., Kuemmerle-Deschner, J., Fasshauer, M., Minden, K., Foeldvari, I., Rietschel, C., Windschall, D., Trauzeddel, R., Hufnagel, M., Foell, D., Berendes, R., Boeschow, G., Oommen, P., Dressler, F., and Horneff, G.

Published
2022

31. New and updated recommendations for the treatment of juvenile idiopathic arthritis associated uveitis and idiopathic chronic anterior uveitis

Author

Foeldvari I, Maccora I, Petrushkin H, Rahman N, Anton-Lopez J, de Boer J, Calzada J, Carreras E, Diaz J, Edelsten C, Angeles-Han ST, Heiligenhaus A, Miserocchi E, Nielsen S, Saurenmann RK, Stuebiger N, Baquet-Walscheid K, Furst D, and Simonini G

Abstract

OBJECTIVE: The Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC) identified the need to update the current guidelines and worked to produce this document, which should serve to guide clinicians managing children with juvenile idiopathic arthritis associated uveitis (JIAU) and idiopathic chronic anterior uveitis (CAU). METHODS: The group analysed the literature published between December 2014- June 2020 after a systematic literature review conducted by two clinicians. Paediatric rheumatologists were paired with ophthalmologists to review the eligible 37 publications. The search criteria were selected to reflect those used for the 2018 SHARE recommendations in order to provide an update, rather than a replacement for that publication. The consensus meeting was moderated by Prof Dan Furst MD, UCLA, Los Angeles, USA. The summary of the current evidence for each SHARE recommendation was presented to the expert committee. These were then discussed and revised during a video consensus meeting on the 22(nd) of January 2021 with 14 voting participants, using a Nominal Group Technique to reach consensus. RESULTS: JIAU treatment was extended to include CAU. Fourteen recommendations regarding treatment of JIAU und CAU with > 80% agreement were accepted. CONCLUSION: An update to the previous 2018 SHARE recommendations for the treatment of children with JIAU with the addition of CAU was created using an evidence-based consensus process. This guideline should help support clinicians to care for children and young people with chronic anterior uveitis.

Published
2022

32. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee

Author

Giancane G1, Swart JF2, Castagnola E3, Groll AH4, Horneff G5, 6, Huppertz HI7, Lovell DJ8, Wolfs T2, Herlin T9, Dolezalova P10, Sanner H11, Susic G13, Sztajnbok F14, Maritsi D15, Constantin T16, Vargova V17, Sawhney S18, Rygg M19, K Oliveira S21, Cattalini M22, Bovis F1, Bagnasco F1, Pistorio A23, Martini A24, Wulffraat N2, Ruperto N25, Paediatric Rheumatology International Trials Organisation (PRINTO). Cuttica R, Garay SM, Brunner J, Emminger W, Appenzeller S, Len C, Saad Magalhaes C, Telcharova-Mihaylovska A, Harjacek M, Jelusic M, Estmann A, Nielsen S, Herrera Mora C, Gervais E, Koné-Paut I, Quartier P, Foeldvari I, Horneff G, Lutz T, Minden K, Tzaribachev N, Trachana M, Tsitsami E, Vougiouka O, Orban I, Harel L, Hashkes P, Uziel Y, Cimaz R, Civino A, Consolini R, D'Angelo G, De Benedetti F, Filocamo G, Fueri E, Gallizzi R, Maggio MC, Magnolia MG, Miniaci A, Montin D, Olivieri A. N., Pastore S, Rigante D, Zulian F, Rumba-Rozenfelde I, Stanevicha V, Panaviene V, Rodriguez Lozano AL, Rubio-Perez N, Vega Cornejo G, Hoppenreijs E, Kamphuis S, Flato B, Nordal EB, Abdwani R, Miraval T, Paz Gastanaga ME, Smolewska E, Ailioaie C, Cochino AV, Laday M, Lazar C, Alexeeva E, Chasnyk V, Keltsev V, Suwairi WMS, Vijatov-Djuric G, Vojinovic J, Arkachaisri T, Koskova E, Avcin T, Ally M, Van Rensburg CJ, Louw I, Lopez JA, Boteanu AL, Calvo Penades I, De Inocencio J, Mesa-Del-Castillo P, Moreno E, Remesal A, Hofer M, Gok F, Ozen S, Ramanan A, Pallotti C, Villa L., Giancane, G1, Swart, Jf2, Castagnola, E3, Groll, Ah4, Horneff, G5, Huppertz, Hi7, Lovell, Dj8, Wolfs, T2, Herlin, T9, Dolezalova, P10, Sanner, H11, Susic, G13, Sztajnbok, F14, Maritsi, D15, Constantin, T16, Vargova, V17, Sawhney, S18, Rygg, M19, K Oliveira, S21, Cattalini, M22, Bovis, F1, Bagnasco, F1, Pistorio, A23, Martini, A24, Wulffraat, N2, Ruperto, N25, Paediatric Rheumatology International Trials Organisation (PRINTO)., Cuttica R, Garay, Sm, Brunner, J, Emminger, W, Appenzeller, S, Len, C, Saad Magalhaes, C, Telcharova-Mihaylovska, A, Harjacek, M, Jelusic, M, Estmann, A, Nielsen, S, Herrera Mora, C, Gervais, E, Koné-Paut, I, Quartier, P, Foeldvari, I, Horneff, G, Lutz, T, Minden, K, Tzaribachev, N, Trachana, M, Tsitsami, E, Vougiouka, O, Orban, I, Harel, L, Hashkes, P, Uziel, Y, Cimaz, R, Civino, A, Consolini, R, D'Angelo, G, De Benedetti, F, Filocamo, G, Fueri, E, Gallizzi, R, Maggio, Mc, Magnolia, Mg, Miniaci, A, Montin, D, Olivieri, A. N., Pastore, S, Rigante, D, Zulian, F, Rumba-Rozenfelde, I, Stanevicha, V, Panaviene, V, Rodriguez Lozano, Al, Rubio-Perez, N, Vega Cornejo, G, Hoppenreijs, E, Kamphuis, S, Flato, B, Nordal, Eb, Abdwani, R, Miraval, T, Paz Gastanaga, Me, Smolewska, E, Ailioaie, C, Cochino, Av, Laday, M, Lazar, C, Alexeeva, E, Chasnyk, V, Keltsev, V, Suwairi, Wm, Vijatov-Djuric, G, Vojinovic, J, Arkachaisri, T, Koskova, E, Avcin, T, Ally, M, Van Rensburg, Cj, Louw, I, Lopez, Ja, Boteanu, Al, Calvo Penades, I, De Inocencio, J, Mesa-Del-Castillo, P, Moreno, E, Remesal, A, Hofer, M, Gok, F, Ozen, S, Ramanan, A, Pallotti, C, Villa, L., Giancane, Gabriella, Swart, Joost F, Castagnola, Elio, Groll, Andreas H, Horneff, Gerd, Huppertz, Hans-Iko, Lovell, Daniel J, Wolfs, Tom, Herlin, Troel, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tama, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, K Oliveira, Sheila, Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Mari, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thoma, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis-Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, Villa, Luca, and Pediatrics

Subjects
Male, lcsh:Diseases of the musculoskeletal system, Biologic, Paediatrics: 760 [VDP], Artritis infecciosa, MedDRA, Infants malalts, Arthritis, Severity of Illness Index, Hospital patients, Cohort Studies, Pharmacovigilance, 0302 clinical medicine, 030212 general & internal medicine, Registries, Child, Biologics, Immunosuppressive therapy, Infections, Juvenile idiopathic arthritis, Opportunistic, biologics, immunosuppressive therapy, infections, juvenile idiopathic arthritis, opportunistic, Barneleddgikt, 3. Good health, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Antirheumatic Agents, Child, Preschool, Cohort, Pediatric Infectious Disease, Female, Infection, Research Article, medicine.medical_specialty, Tuberculosis, juvenil idiopathic arthritis, Opportunistic Infections, Herpes Zoster, 03 medical and health sciences, Immunocompromised Host, Juvenile idiopathic arthriti, Internal medicine, medicine, Humans, book, 030203 arthritis & rheumatology, Malalts hospitalitzats, Immunosupressió, business.industry, Sick children, medicine.disease, Rheumatology, Arthritis, Juvenile, Infectious arthritis, Pediatri: 760 [VDP], Orthopedic surgery, Opportunistiske infeksjoner, book.journal, lcsh:RC925-935, business, Infeccions oportunistes, Immunosuppression
Abstract

Background: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). Methods: The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI. Results: A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI. Conclusions: We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies. © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Published
2020
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33. Subcutaneous Abatacept in Patients With Polyarticular-Course Juvenile Idiopathic Arthritis

Author

Brunner H. I., Tzaribachev N., Vega-Cornejo G., Louw I., Berman A., Calvo Penades I., Anton J., Avila-Zapata F., Cuttica R., Horneff G., Foeldvari I., Keltsev V., Kingsbury D. J., Viola D. O., Joos R., Lauwerys B., Paz Gastanaga M. E., Rama M. E., Wouters C., Bohnsack J., Breedt J., Fischbach M., Lutz T., Minden K., Miraval T., Ally M. M. T. M., Rubio-Perez N., Solau Gervais E., van Zyl R., Li X., Nys M., Wong R., Banerjee S., Lovell D. J., Martini A., Ruperto N., Becker M. L., Ilowite N. T., Dare J. A., Morris P. K., Beukelman T. G., Wagner-Weiner L., Zemel L., Quartier P., Kone-Paut I., Belot A., Gerloni V., Ferrandiz M., Van Rensburg D. J., Scheibel I. M., Goldstein-Schainberg C., Silva C., Terreri M. T. S. E. L. A., Gamir M., Burgos Vargas R., Faugier Fuentes E., Cimaz R., Alessio M., Espada G., Brunner, H. I., Tzaribachev, N., Vega-Cornejo, G., Louw, I., Berman, A., Calvo Penades, I., Anton, J., Avila-Zapata, F., Cuttica, R., Horneff, G., Foeldvari, I., Keltsev, V., Kingsbury, D. J., Viola, D. O., Joos, R., Lauwerys, B., Paz Gastanaga, M. E., Rama, M. E., Wouters, C., Bohnsack, J., Breedt, J., Fischbach, M., Lutz, T., Minden, K., Miraval, T., Ally, M. M. T. M., Rubio-Perez, N., Solau Gervais, E., van Zyl, R., Li, X., Nys, M., Wong, R., Banerjee, S., Lovell, D. J., Martini, A., Ruperto, N., Becker, M. L., Ilowite, N. T., Dare, J. A., Morris, P. K., Beukelman, T. G., Wagner-Weiner, L., Zemel, L., Quartier, P., Kone-Paut, I., Belot, A., Gerloni, V., Ferrandiz, M., Van Rensburg, D. J., Scheibel, I. M., Goldstein-Schainberg, C., Silva, C., Terreri, M. T. S. E. L. A., Gamir, M., Burgos Vargas, R., Faugier Fuentes, E., Cimaz, R., Alessio, M., and Espada, G.

Subjects
Male, musculoskeletal diseases, 0301 basic medicine, medicine.medical_specialty, Adolescent, genetic structures, Immunology, Juvenile, Arthritis, Injections, Subcutaneou, Abatacept, Arthritis, Juvenile, Child, Child, Preschool, Cohort Studies, Female, Humans, Immunosuppressive Agents, Injections, Subcutaneous, Treatment Outcome, Injections, Immunosuppressive Agent, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Pharmacokinetics, Open label study, medicine, Immunology and Allergy, In patient, Preschool, skin and connective tissue diseases, 030203 arthritis & rheumatology, business.industry, Subcutaneous, medicine.disease, Dermatology, Clinical trial, 030104 developmental biology, Methotrexate, Cohort Studie, business, Human, medicine.drug
Abstract

Objective: To investigate the pharmacokinetics, effectiveness, and safety of subcutaneous (SC) abatacept treatment over 24 months in patients with polyarticular-course juvenile idiopathic arthritis (JIA). Methods: In this phase III, open-label, international, multicenter, single-arm study, patients with polyarticular JIA (cohort 1, ages 6–17 years and cohort 2, ages 2–5 years) in whom treatment with ≥1 disease-modifying antirheumatic drug was unsuccessful received weight-tiered SC abatacept weekly: 10 to

Published
2018
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34. Patients with juvenile systemic sclerosis have a distinct pattern of organ involvement. Results from thejuvenile systemic sclerosis inception cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Stanevicha, V, Anton, J, Sztajnbok, F, Khubchandani, R, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Marrani, E, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, and Helmus, N

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Juvenile systemic sclerosis (jSSc) is a rare disease with a prevalence of around 3 in 1,000,000 children. To better capture the clinical manifestations of jSSc the juvenile systemic sclerosis inception cohort (jSScC, [link:https://www.juvenile-scleroderma.com/*https://www.juvenile-scleroderma.com/])[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021
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36. Differences sustained between diffuse and limited forms of juvenile systemic sclerosis in expanded international cohort. www.juvenile-scleroderma.com

Author

Foeldvari I, Klotsche J, Kasapcopur O, Adrovic A, Terreri MT, Sakamoto AP, Stanevicha V, Sztajnbok F, Anton-Lopez J, Feldman B, Alexeeva E, Katsicas M, Smith V, Avcin T, Marrani E, Kostik M, Lehman T, Sifuentes-Giraldo WA, Vasquez-Canizares N, Appenzeller S, Janarthanan M, Moll M, Nemcova D, Patwardhan A, Santos MJ, Sawhney S, Schonenberg-Meinema D, Battagliotti C, Berntson L, Bica B, Brunner J, Costa-Reis P, Eleftheriou D, Harel L, Horneff G, Kaiser D, Kallinich T, Lazarevic D, Minden K, Nielsen S, Nuruzzaman F, Uziel Y, Helmus N, and Torok KS

Abstract

OBJECTIVES: To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (jSSc) patients in the international Juvenile SSc Inception Cohort (jSScC), compare these characteristics between the classically defined diffuse (dcjSSc) and limited cutaneous (lcjSSc) subtypes, and among those with overlap features. METHODS: A cross-sectional study was performed using baseline visit data. Demographic, organ system evaluation, treatment, and patient and physician reported outcomes were extracted and summary statistics applied. Comparisons between dcjSSc and lcSSc subtypes and patients with and without overlap features were performed using Chi-square and Mann Whitney U-tests. RESULTS: At data extraction 150 jSSc patients were enrolled across 42 centers, 83% were Caucasian, 80% female, dcjSSc predominated (72%), and 17% of the cohort had overlap features. Significant differences were found between dcjSSc and lcjSSc regarding the modified Rodnan Skin Score, presence of Gottron's papules, digital tip ulceration, 6 Minute walk test, composite pulmonary and cardiac involvement. All more frequent in dcSSc except for cardiac involvement. DcjSSc patients had significantly worse scores for physician rated disease activity and damage. A significantly higher occurrence of Gottron's papules, musculoskeletal involvement and composite pulmonary involvement, and significantly lower frequency of Raynaud's phenomenon, were seen in those with overlap features. CONCLUSION: Results from a large international jSSc cohort demonstrate significant differences between dcjSSc and lcjSSc patients including more globally severe disease and increased frequency of ILD in dcjSSc patients, while those with lcSSc have more frequent cardiac involvement. Those with overlap features had an unexpected higher frequency of interstitial lung disease.

Published
2021

37. Consensus-based recommendations for the management of juvenile systemic sclerosis

Author

Foeldvari I, Culpo R, Sperotto F, Anton-Lopez J, Avcin T, Baildam E, Boros C, Chaitow J, Constantin T, Kasapcopur O, Knupp Feitosa de Oliveira S, Pilkington C, Toplak N, van Royen A, Saad Magalhaes C, Vastert SJ, Wulffraat N, and Zulian F

Subjects
recommendations, treatment, juvenile systemic sclerosis, assessment, severity score, outcome, scleroderma
Abstract

Juvenile systemic sclerosis (JSSc) is a rare disease of childhood and currently no international consensus exists with regard to its assessment and treatment. This SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) initiative, based on expert opinion informed by the best available evidence, provides recommendations for the assessment and treatment of patients with JSSc with a view to improving their outcome. Experts focused attention not only on the skin assessment but also on the early signs of internal organ involvement whose proper treatment can significantly affect the long-term outcome. A score for disease severity is proposed in order to perform a structured assessment of outcome over time but a validation in a wider patient population is recommended. Finally, a stepwise treatment approach is proposed in order to unify the standard of care throughout Europe with the aim to reduce morbidity and mortality in this disease.

Published
2021

38. Patients with Juvenile Systemic Sclerosis Have a Distinct Pattern of Organ Involvement: Results from the Juvenile Systemic Sclerosis Inception Cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, M, Sakamoto, AP, Sztajnbok, F, Feldman, B, Stanevicha, V, Anton-Lopez J, Khubchandani, R, Alexeeva, E, Johnson, S, Katsicas, MM, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Marrani, E, Schonenberg-Meinema, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Malcova, H, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Battagliotti, C, Berntson, L, Bica, BERG, Brunner, J, Cimaz, R, Reis, PC, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nielsen, S, Nuruzzaman, F, Hetlevik, SO, Uziel, Y, and Helmus, N

Published
2021

40. Male Juvenile Systemic Sclerosis Patients Have More Severe Disease: Results from the International Juvenile Scleroderma Inception Cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, M, Sakamoto, AP, Sztajnbok, F, Feldman, B, Stanevicha, V, Anton-Lopez J, Khubchandani, R, Alexeeva, E, Johnson, S, Katsicas, MM, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Marrani, E, Schonenberg-Meinema, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Malcova, H, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Battagliotti, C, Berntson, L, Bica, BERG, Brunner, J, Cimaz, R, Reis, PC, Eleftheriou, D, Harel, L, Horneff, G, Kaiser, D, Kallinich, T, Lazarevic, D, Minden, K, Nielsen, S, Nuruzzaman, F, Hetlevik, SO, Uziel, Y, and Helmus, N

Published
2021

41. Juvenile systemic sclerosis (jSSc) patients with overlap characteristics do not have mild disease.Results from thejSSc inception cohort

Author

Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Stanevicha, V, Anton, J, Sztajnbok, F, Khubchandani, R, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Marrani, E, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, Helmus, N, Foeldvari, I, Klotsche, J, Kasapcopur, O, Adrovic, A, Torok, K, Terreri, MT, Sakamoto, AP, Feldman, B, Stanevicha, V, Anton, J, Sztajnbok, F, Khubchandani, R, Alexeeva, E, Katsicas, M, Sawhney, S, Smith, V, Appenzeller, S, Avcin, T, Kostik, M, Lehman, T, Marrani, E, Schonenberg, D, Sifuentes-Giraldo, WA, Vasquez-Canizares, N, Janarthanan, M, Moll, M, Nemcova, D, Patwardhan, A, Santos, MJ, and Helmus, N

Published
2021

42. COMPARISON OF THREE DIFFERENT ALGORITHMS FOR THE TREATMENT OF CHILDREN WITH POLYARTICULAR JIA: THE FIRST YEAR AFTER DIAGNOSIS

Author

Minden, K., Schwarz, T., Dressler, F., Foeldvari, I., Haas, J. P., Horneff, G., Hospach, T., Kuemmerle-Deschner, J., Moenkemoeller, K., Weller-Heinemann, F., Tenbrock, K., Niewerth, M., Sengler, C., Foell, D., Klotsche, J., Minden, K., Schwarz, T., Dressler, F., Foeldvari, I., Haas, J. P., Horneff, G., Hospach, T., Kuemmerle-Deschner, J., Moenkemoeller, K., Weller-Heinemann, F., Tenbrock, K., Niewerth, M., Sengler, C., Foell, D., and Klotsche, J.

Published
2021

43. Langzeitwirksamkeit und -sicherheit von Canakinumab bei Patienten mit Familiärem Mittelmeerfieber (FMF) - Interimsanalyse des RELIANCE-Registers

Author

Henes, J, Kümmerle-Deschner, J, Kallinich, T, Dressler, F, Weller-Heinemann, F, Kortus-Götze, B, Foeldvari, I, Horneff, G, Hufnagel, M, Meier, F, Weber-Arden, J, Blank, N, Henes, J, Kümmerle-Deschner, J, Kallinich, T, Dressler, F, Weller-Heinemann, F, Kortus-Götze, B, Foeldvari, I, Horneff, G, Hufnagel, M, Meier, F, Weber-Arden, J, and Blank, N

Published
2021

44. Under detection of interstitial lung disease in juvenile systemic sclerosis (jSSc)

Author

Foeldvari I, Klotsche J, Hinrichs B, Helmus N, Kasapcopur O, Adrovic A, Sztajnbok F, Terreri MT, Anton-Lopez J, Smith V, Katsicas M, Kostik M, Vasquez-Canizares N, Avcin T, Feldman B, Janarthanan M, Santos MJ, Sawhney S, Schonenberg-Meinema D, Sifuentes-Giraldo WA, Alexeeva E, Appenzeller S, Battagliotti C, Berntson L, Bica B, Costa Reis P, Eleftheriou D, Kallinich T, Lehman T, Marrani E, Minden K, Nielsen S, Nuruzzaman F, Patwardhan A, Khubchandani R, Stanevicha V, Uziel Y, and Torok KS

Subjects
respiratory system, behavioral disciplines and activities, respiratory tract diseases
Abstract

OBJECTIVES: Utilizing data obtained from a prospective international juvenile systemic sclerosis cohort (jSScC) to determine if pulmonary screening with forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO) is sufficient to assess the presence of interstitial lung disease (ILD) in comparison to high resolution computed tomography (HRCT) in jSSc. METHODS: The jSScC cohort database was queried for patients enrolled from January 2008 to January 2020 with recorded pulmonary function tests (PFT) parameters and HRCT to determine the discriminatory properties of PFTs parameters, FVC and DLCO, in detecting ILD. RESULTS: Eighty-six jSSc patients had both CT imaging and FVC values for direct comparison. Using findings on HRCT as the standard measure of ILD presence, the sensitivity of FVC in detecting ILD in jSSc was only 40%, the specificity was 77%, and AUC was 0.58. Fifty-eight jSSc patients had both CT imaging and DLCO values for comparison. The sensitivity of DLCO in detecting ILD was 76%, the specificity was 70%, and AUC was 0.73. CONCLUSION: The performance of PFTs in jSSc to detect underlying ILD was quite limited. Specifically, the FVC, which is one of the main clinical parameters in adult SSc to detect and monitor ILD, would miss approximately 60% of children that had ILD changes on their accompanying HRCT. The DLCO was more sensitive in detecting potential abnormalities in HRCT, but with less specificity than the FVC. These results support the use of HRCT in tandem with PFTs for the screening of ILD in jSSc.

Published
2020

45. Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

Author

Smith, V., Herrick, A.L., Ingegnoli, F., Damjanov, N., Angelis, R. De, Denton, C.P., Distler, O., Espejo, K., Foeldvari, I., Frech, T., Garro, B., Gutierrez, M., Gyger, G., Hachulla, E., Hesselstrand, R., Iagnocco, A., Kayser, C., Melsens, K., Muller-Ladner, U., Paolino, S., Pizzorni, C., Radic, M., Riccieri, V., Snow, M., Stevens, W.B.C., Sulli, A., Laar, J.M. van, Vonk, M.C., Vanhaecke, A., Cutolo, M., Smith, V., Herrick, A.L., Ingegnoli, F., Damjanov, N., Angelis, R. De, Denton, C.P., Distler, O., Espejo, K., Foeldvari, I., Frech, T., Garro, B., Gutierrez, M., Gyger, G., Hachulla, E., Hesselstrand, R., Iagnocco, A., Kayser, C., Melsens, K., Muller-Ladner, U., Paolino, S., Pizzorni, C., Radic, M., Riccieri, V., Snow, M., Stevens, W.B.C., Sulli, A., Laar, J.M. van, Vonk, M.C., Vanhaecke, A., and Cutolo, M.

Abstract

Contains fulltext : 219902.pdf (Publisher’s version ) (Open Access), Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progression, capillaroscopy became a 'mainstream' investigation for rheumatologists. Given its increasing use by a variety of physicians internationally both in daily practice to differentiate primary from secondary Raynaud's phenomenon, as well as in research context to predict disease progression and monitor treatment effects, standardisation in capillaroscopic image acquisition and analysis seems paramount. To step forward to this need, experts in the field of capillaroscopy/microcirculation provide in this very consensus paper their view on image acquisition and analysis, different capillaroscopic techniques, normal and abnormal capillaroscopic characteristics and their meaning, scoring systems and reliability of image acquisition and interpretation.

Published
2020

47. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee

Author

Giancane, G, Swart, Jf, Castagnola, E, Groll, Ah, Horneff, G, Huppertz, Hi, Lovell, Dj, Wolfs, T, Herlin, T, Dolezalova, P, Sanner, H, Susic, G, Sztajnbok, F, Maritsi, D, Constantin, T, Vargova, V, Sawhney, S, Rygg, M, K Oliveira, S, Cattalini, M, Bovis, F, Bagnasco, F, Pistorio, A, Martini, A, Wulffraat, N, Ruperto, N, Cuttica, R, Garay, Sm, Brunner, J, Emminger, W, Appenzeller, S, Len, C, Saad Magalhaes, C, Telcharova-Mihaylovska, A, Harjacek, M, Jelusic, M, Estmann, A, Nielsen, S, Herrera Mora, C, Gervais, E, Koné-Paut, I, Quartier, P, Foeldvari, I, Lutz, T, Minden, K, Tzaribachev, N, Trachana, M, Tsitsami, E, Vougiouka, O, Orban, I, Harel, L, Hashkes, P, Uziel, Y, Cimaz, R, Civino, A, Consolini, R, D'Angelo, G, De Benedetti, F, Filocamo, G, Fueri, E, Gallizzi, R, Maggio, Mc, Magnolia, Mg, Miniaci, A, Montin, D, Olivieri, An, Pastore, S, Rigante, Donato, Zulian, F, Rumba-Rozenfelde, I, Stanevicha, V, Panaviene, V, Rodriguez Lozano, Al, Rubio-Perez, N, Vega Cornejo, G, Hoppenreijs, E, Kamphuis, S, Flato, B, Nordal, Eb, Abdwani, R, Miraval, T, Paz Gastanaga, Me, Smolewska, E, Ailioaie, C, Cochino, Av, Laday, M, Lazar, C, Alexeeva, E, Chasnyk, V, Keltsev, V, Suwairi, Wm, Vijatov-Djuric, G, Vojinovic, J, Arkachaisri, T, Koskova, E, Avcin, T, Ally, M, Van Rensburg, Cj, Louw, I, Lopez, Ja, Boteanu, Al, Calvo Penades, I, De Inocencio, J, Mesa-Del-Castillo, P, Moreno, E, Remesal, A, Hofer, M, Gok, F, Ozen, S, Ramanan, A, Pallotti, C, Villa, L &amp, Paediatric Rheumatology International Trials Organisation, (PRINTO), Rigante D (ORCID:0000-0001-7032-7779), Giancane, G, Swart, Jf, Castagnola, E, Groll, Ah, Horneff, G, Huppertz, Hi, Lovell, Dj, Wolfs, T, Herlin, T, Dolezalova, P, Sanner, H, Susic, G, Sztajnbok, F, Maritsi, D, Constantin, T, Vargova, V, Sawhney, S, Rygg, M, K Oliveira, S, Cattalini, M, Bovis, F, Bagnasco, F, Pistorio, A, Martini, A, Wulffraat, N, Ruperto, N, Cuttica, R, Garay, Sm, Brunner, J, Emminger, W, Appenzeller, S, Len, C, Saad Magalhaes, C, Telcharova-Mihaylovska, A, Harjacek, M, Jelusic, M, Estmann, A, Nielsen, S, Herrera Mora, C, Gervais, E, Koné-Paut, I, Quartier, P, Foeldvari, I, Lutz, T, Minden, K, Tzaribachev, N, Trachana, M, Tsitsami, E, Vougiouka, O, Orban, I, Harel, L, Hashkes, P, Uziel, Y, Cimaz, R, Civino, A, Consolini, R, D'Angelo, G, De Benedetti, F, Filocamo, G, Fueri, E, Gallizzi, R, Maggio, Mc, Magnolia, Mg, Miniaci, A, Montin, D, Olivieri, An, Pastore, S, Rigante, Donato, Zulian, F, Rumba-Rozenfelde, I, Stanevicha, V, Panaviene, V, Rodriguez Lozano, Al, Rubio-Perez, N, Vega Cornejo, G, Hoppenreijs, E, Kamphuis, S, Flato, B, Nordal, Eb, Abdwani, R, Miraval, T, Paz Gastanaga, Me, Smolewska, E, Ailioaie, C, Cochino, Av, Laday, M, Lazar, C, Alexeeva, E, Chasnyk, V, Keltsev, V, Suwairi, Wm, Vijatov-Djuric, G, Vojinovic, J, Arkachaisri, T, Koskova, E, Avcin, T, Ally, M, Van Rensburg, Cj, Louw, I, Lopez, Ja, Boteanu, Al, Calvo Penades, I, De Inocencio, J, Mesa-Del-Castillo, P, Moreno, E, Remesal, A, Hofer, M, Gok, F, Ozen, S, Ramanan, A, Pallotti, C, Villa, L &amp, Paediatric Rheumatology International Trials Organisation, (PRINTO), and Rigante D (ORCID:0000-0001-7032-7779)

Abstract

BACKGROUND: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). METHODS: The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI. RESULTS: A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI. CONCLUSIONS: We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies.

Published
2020

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