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Introduction: To protect public health, it is important that the population be vaccinated against COVID-19; however, certain factors can affect vaccine acceptance., Objective: The objective of this study was to determine whether religious fatalism and concern about new variants have a significant effect on the acceptance of COVID-19 vaccines., Methodology: An explanatory study was conducted with 403 adults of legal age captured through non-probabilistic convenience sampling in vaccination centers in the 13 health networks of the Regional Health Directorate of Puno, Peru. Data were collected through a brief scale of religious fatalism, a scale of acceptance of vaccines against COVID-19 and a scale of concern about a new variant of COVID-19., Results: The proposed model obtained an adequate fit. There was a negative effect of religious fatalism on vaccine acceptance, a positive effect of fatalism on vaccine rejection, a positive effect of concern about new variants on the acceptance of vaccines, and a positive effect of concern about new variants on vaccine rejection., Conclusion: These findings provide evidence for the usefulness of considering both religious fatalism and concern about new variants affect the intention to receive the COVID-19 vaccine in adults in southern Peru., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Mamani-Benito, Farfán-Solís, Huayta-Meza, Tito-Betancur, Morales-García and Tarqui.)

Due to the emotional impact of COVID-19 on university students, the goal was to explore the relationship between anxiety, depression, psychological well-being, and life satisfaction among pre-professional interns. The research was carried out using an explanatory cross-sectional design, with the participation of 1011 pre-professional interns of 13 health networks from the department of Puno (Peru). Data were collected using the Satisfaction with Life Scale, Generalized Anxiety Disorder Scale-2, Patient Health Questionnaire 2, and the Psychological Wellbeing Scale. The main data analysis was carried out using the R statistical software, and implementing the confirmatory factor analysis technique, which evidenced that the explanatory model provides an acceptable value. Based on the above, a negative relationship between depression and life satisfaction, (β = -.60, p < .001) and a positive relationship between anxiety and life satisfaction (β = .28, p < .001) was shown, in addition to a mediating effect of the psychological wellbeing related to depression and life satisfaction (p < .001). In conclusion, life satisfaction is explained concerning the degree of depression and anxiety, as well as the moderating effect of psychological well-being. Despite that, there is an urgent need to take preventive actions to strengthen the mental health of the pre-professional health interns, who have also been providing support during the COVID-19 pandemic., Competing Interests: The authors declare no conflict of interest., (© 2022 The Authors.)