9 results on '"Fabre, Mélanie"'
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2. Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis
- Author
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Quilichini, Evans, Fabre, Mélanie, Dirami, Thassadite, Stedman, Aline, De Vas, Matias, Ozguc, Ozge, Pasek, Raymond C., Cereghini, Silvia, Morillon, Lucie, Guerra, Carmen, Couvelard, Anne, Gannon, Maureen, and Haumaitre, Cécile
- Published
- 2019
- Full Text
- View/download PDF
3. Investigating Neolithic and the Middle Ages caprine herds mobility in French island of Corsica
- Author
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Fabre, Mélanie, James, Hannah, Forest, Vianney, Ranché, Christophe, Giovannangelli, Gilles, Istria, Daniel, Fiorillo, Denis, Cucchi, Thomas, Vigne, Jean-Denis, Snoeck, Christophe, Balasse, Marie, Chemistry, History, Archeology, Arts, Philosophy and Ethics, Multidisciplinary Archaeological Research Institute, and Analytical, Environmental & Geo-Chemistry
- Abstract
Agropastoral societies settled in Corsica in the mid-6th millennium BC. They mainly settled along the coastal areas but their presence is also attested in the high mountains of the island's interior from the Neolithic period. The occupation of both coastal plains and mountainous areas could be linked to pastoral activity involving herds mobility. Nowadays, traditional sheep and goat breeding systems in Corsica mainly consist of dairy farming of flocks. Demographic management is mostly based on autumnal lambing, while the management of forage resources is based on seasonal grazing in a double transhumance system. The herds spend the winter on the low elevation plains, go up to mid-height elevation in the spring, and summer in high mountains. Then they make a stopover (a capicursura) in the middle mountains in the autumn, before returning to the plains for winter (impiaghjera). However, land use patterns in mountainous areas are not immutable. They may have been very different in the past and must be investigated directly from archaeological evidence. This presentation will sum up the results from ongoing research on pastoral mobility in the Neolithic and the Middle Ages in Corsica, involving sequential analysis of oxygen (δ18O), carbon (δ13C) and strontium (87Sr/86Sr) isotope ratios in caprine dental enamel from two Neolithic sites: Montlaur (4050-3500 BC) and Araguina Sennola (5th-3rd millennium BC), and two medieval sites: Litala and Rostino (14th century AD). We have observed variations in feeding over the course of the annual cycle. Carbon isotope ratios (δ13C) showed diverse patterns of seasonal changes, involving forest resources in winter as well as intriguing high-δ13C plant resources in summer (C4 plants?). Seasonal mobility of the herds was confirmed from intra-tooth variations in 87Sr/86Sr values. The results showed large intra-tooth variations, concomitant to seasonal changes in δ18O values. In addition, high inter-individual variability can be interpreted as reflecting the diversity in management and grazing patterns that characterizes these systems., Agropastoral societies settled in Corsica in the mid-6th millennium BC. They mainly settled along the coastal areas but their presence is also attested in the high mountains of the island's interior from the Neolithic period. The occupation of both coastal plains and mountainous areas could be linked to pastoral activity involving herds mobility. Nowadays, traditional sheep and goat breeding systems in Corsica mainly consist of dairy farming of flocks. Demographic management is mostly based on autumnal lambing, while the management of forage resources is based on seasonal grazing in a double transhumance system. The herds spend the winter on the low elevation plains, go up to mid-height elevation in the spring, and summer in high mountains. Then they make a stopover (a capicursura) in the middle mountains in the autumn, before returning to the plains for winter (impiaghjera). However, land use patterns in mountainous areas are not immutable. They may have been very different in the past and must be investigated directly from archaeological evidence. This presentation will sum up the results from ongoing research on pastoral mobility in the Neolithic and the Middle Ages in Corsica, involving sequential analysis of oxygen (δ18O), carbon (δ13C) and strontium (87Sr/86Sr) isotope ratios in caprine dental enamel from two Neolithic sites: Montlaur (4050-3500 BC) and Araguina Sennola (5th-3rd millennium BC), and two medieval sites: Litala and Rostino (14th century AD). We have observed variations in feeding over the course of the annual cycle. Carbon isotope ratios (δ13C) showed diverse patterns of seasonal changes, involving forest resources in winter as well as intriguing high-δ13C plant resources in summer (C4 plants?). Seasonal mobility of the herds was confirmed from intra-tooth variations in 87Sr/86Sr values. The results showed large intra-tooth variations, concomitant to seasonal changes in δ18O values. In addition, high inter-individual variability can be interpreted as reflecting the diversity in management andgrazing patterns that characterizes these systems.
- Published
- 2022
4. Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease
- Author
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Quilichini, Evans, Fabre, Mélanie, Nord, Christoffer, Dirami, Thassadite, Le Marec, Axelle, Cereghini, Silvia, Pasek, Raymond C, Gannon, Maureen, Ahlgren, Ulf, Haumaitre, Cécile, Quilichini, Evans, Fabre, Mélanie, Nord, Christoffer, Dirami, Thassadite, Le Marec, Axelle, Cereghini, Silvia, Pasek, Raymond C, Gannon, Maureen, Ahlgren, Ulf, and Haumaitre, Cécile
- Abstract
Maturity‐onset diabetes of the young type 5 (MODY5) is due to heterozygous mutations or deletion of HNF1B. No mouse models are currently available to recapitulate the human MODY5 disease. Here, we investigate the pancreatic phenotype of a unique MODY5 mouse model generated by heterozygous insertion of a human HNF1B splicing mutation at the intron‐2 splice donor site in the mouse genome. This Hnf1bsp2/+ model generated with targeted mutation of Hnf1b mimicking the c.544+1G>T (
T) mutation identified in humans, results in alternative transcripts and a 38% decrease of native Hnf1b transcript levels. As a clinical feature of MODY5 patients, the hypomorphic mouse model Hnf1bsp2/+ displays glucose intolerance. Whereas Hnf1bsp2/+ isolated islets showed no altered insulin secretion, we found a 65% decrease in pancreatic insulin content associated with a 30% decrease in total large islet volume and a 20% decrease in total β‐cell volume. These defects were associated with a 30% decrease in expression of the pro‐endocrine gene Neurog3 that we previously identified as a direct target of Hnf1b, showing a developmental etiology. As another clinical feature of MODY5 patients, the Hnf1bsp2/+ pancreases display exocrine dysfunction with hypoplasia. We observed chronic pancreatitis with loss of acinar cells, acinar‐to‐ductal metaplasia, and lipomatosis, with upregulation of signaling pathways and impaired acinar cell regeneration. This was associated with ductal cell deficiency characterized by shortened primary cilia. Importantly, the Hnf1bsp2/+ mouse model reproduces the pancreatic features of the human MODY5/HNF1B disease, providing a unique in vivo tool for molecular studies of the endocrine and exocrine defects and to advance basic and translational research. - Published
- 2021
- Full Text
- View/download PDF
5. Françoise F. Laot & Claudie Solar (dir.), Pionnières de l’éducation des adultes, perspectives internationales
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Fabre, Mélanie
- Abstract
Ce livre intitulé Pionnières de l’éducation des adultes brosse en neuf chapitres onze portraits de femmes engagées au xixe et au xxe siècle. Leur grande diversité à la fois en ce qui concerne leur nationalité, leur milieu social d’origine, leur formation intellectuelle, leur culture politique et la forme concrète que prennent leurs actions en faveur de l’éducation des adultes est à la source des forces et de quelques faiblesses de cette étude. C’est une des forces de l’ouvrage, car dans son ...
- Published
- 2020
6. Françoise F. Laot & Claudie Solar (dir.), Pionnières de l’éducation des adultes, perspectives internationales
- Author
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Fabre, Mélanie, primary
- Published
- 2019
- Full Text
- View/download PDF
7. Metabolic Profiling of Multiorgan Samples : Evaluation of MODY5/RCAD Mutant Mice
- Author
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Torell, Frida, Bennet, Kate, Cereghini, Silvia, Fabre, Mélanie, Rännar, Stefan, Lundstedt-Enkel, Katrin, Moritz, Thomas, Haumaitre, Cécile, Trygg, Johan, Lundstedt, Torbjörn, Torell, Frida, Bennet, Kate, Cereghini, Silvia, Fabre, Mélanie, Rännar, Stefan, Lundstedt-Enkel, Katrin, Moritz, Thomas, Haumaitre, Cécile, Trygg, Johan, and Lundstedt, Torbjörn
- Abstract
In the present study, we performed a metabolomics analysis to evaluate a MODY5/RCAD mouse mutant line as a potential model for HNF1B-associated diseases. Gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) of gut, kidney, liver, muscle, pancreas, and plasma samples uncovered the tissue specific metabolite distribution. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) was used to identify the differences between MODY5/RCAD and wild-type mice in each of the tissues. The differences included, for example, increased levels of amino acids in the kidneys and reduced levels of fatty acids in the muscles of the MODY5/RCAD mice. Interestingly, campesterol was found in higher concentrations in the MODY5/RCAD mice, with a four-fold and three-fold increase in kidneys and pancreas, respectively. As expected, the MODY5/RCAD mice displayed signs of impaired renal function in addition to disturbed liver lipid metabolism, with increased lipid and fatty acid accumulation in the liver. From a metabolomics perspective, the MODY5/RCAD model was proven to display a metabolic pattern similar to what would be suspected in HNF1B-associated diseases. These findings were in line with the presumed outcome of the mutation based on the different anatomy and function of the tissues as well as the effect of the mutation on development.
- Published
- 2018
- Full Text
- View/download PDF
8. vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis
- Author
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Lokmane, Ludmilla, primary, Heliot, Claire, additional, Garcia-Villalba, Pilar, additional, Fabre, Mélanie, additional, and Cereghini, Silvia, additional
- Published
- 2010
- Full Text
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9. La jeunesse de Fontenay : l'impulsion de Félix Pécaut pour un nouvel enseignement populaire, féminin et laïque (1880-1899)
- Author
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Mélanie Fabre and FABRE, Mélanie
- Subjects
institutrices ,girls’ education ,teachers ,History and Philosophy of Science ,normal schools ,laïcité ,[SHS.HIST] Humanities and Social Sciences/History ,formation des enseignants ,Éducation des filles ,écoles normales ,teacher training ,secularism ,Education - Abstract
This text analyses the first two decades of the École normale supérieure d’institutrices situated in Fontenay-aux-Roses since its foundation in 1880. Created to train elite female primary teaching staff (headmistresses and teachers in teacher training colleges, female inspectors of primary schools, etc.), the school of Fontenay was deeply influenced by its director of studies: Félix Pécaut (1828-1898). A supporter of an ambitious programme of instruction for women and an advocate of a model of laïcité (secularity) derived from his own belonging to the protestant religion, Félix Pécaut encouraged the “fontenaysiennes” to develop their critical thinking and apply it to every subject. This research analyses the youth of the Fontenay school through the mark that Pécaut made on a dozen of his students. This research is based on texts written by several of his former pupils who spoke up at the turn of the century when attacks against the school were proliferating in the context of the “War between the two Frances” (“Guerre des deux France”). Pécaut being a Dreyfus supporter, he converted Ferdinand Buisson to his cause and led his former pupils to keep a vigilant eye on the situation of the country in this context of political and social crisis. During this chaotic period, the school of Fontenay was frequently attacked in the press. Several “fontenaysiennes” stayed faithful to the legacy of Pécaut in their own teacher training colleges during the Belle Époque. They applied a liberal discipline based on self-government, replicating the traditional morning conferences and keeping in mind Pécaut’s aphorism addressed to “his daughters”: “Dare to be!”., Cet article revient sur les deux premières décennies d’existence de l’École normale supérieure d’institutrices de Fontenay-aux-Roses à partir de sa fondation en 1880. Créée pour former l’élite du corps enseignant primaire féminin (les directrices et professeures d’écoles normales, d’écoles primaires supérieures et les inspectrices), l’école de Fontenay est marquée pendant cette période par l’aura de son directeur des études : Félix Pécaut (1828-1898). Défenseur d’une instruction ambitieuse pour les filles et partisan d’une conception de la laïcité scolaire maintenant une aspiration à la transcendance, cet ancien pasteur protestant encourage les fontenaysiennes à développer leur esprit critique et le principe du libre examen en tout domaine. C’est à travers l’empreinte que Pécaut a laissée sur une dizaine de fontenaysiennes que cet article aborde la jeunesse de l’école de Fontenay. Cette recherche repose sur les textes produits par plusieurs anciennes élèves de « Monsieur l’Inspecteur », qui s’expriment, pour beaucoup d’entre elles, au tournant du XIXᵉ et du XXᵉ siècle, alors que les attaques se multiplient contre Fontenay dans le contexte de la « Guerre des deux France ». L’engagement dreyfusard de Félix Pécaut, qui entraîne avec lui Ferdinand Buisson et qui appelle la communauté des fontenaysiennes à la vigilance, attire en effet sur l’école de Fontenay les foudres de l’opinion conservatrice. La fin du siècle est l’occasion de batailles de plumes dans la presse autour de l’École normale supérieure d’institutrices. De nombreuses fontenaysiennes font malgré tout fructifier l’héritage de Pécaut dans leurs écoles normales pendant toute la Belle Époque, appliquant une discipline libérale fondée sur le self-government, reprenant la tradition des conférences du matin et gardant en tête la maxime pécaldienne adressée à « ses filles » : « Osez être ! ».
- Published
- 2022
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