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Data from high-energy observations are usually obtained as lists of photon events. A common analysis task for such data is to identify whether diffuse emission exists, and to estimate its surface brightness, even in the presence of point sources that may be superposed. We have developed a novel non-parametric event list segmentation algorithm to divide up the field of view into distinct emission components. We use photon location data directly, without binning them into an image. We first construct a graph from the Voronoi tessellation of the observed photon locations and then grow segments using a new adaptation of seeded region growing, that we call Seeded Region Growing on Graph, after which the overall method is named SRGonG. Starting with a set of seed locations, this results in an over-segmented dataset, which SRGonG then coalesces using a greedy algorithm where adjacent segments are merged to minimize a model comparison statistic; we use the Bayesian Information Criterion. Using SRGonG we are able to identify point-like and diffuse extended sources in the data with equal facility. We validate SRGonG using simulations, demonstrating that it is capable of discerning irregularly shaped low surface-brightness emission structures as well as point-like sources with strengths comparable to that seen in typical X-ray data. We demonstrate SRGonG's use on the Chandra data of the Antennae galaxies, and show that it segments the complex structures appropriately.

The Quantum Approximate Optimization Algorithm (QAOA) is a standard method for combinatorial optimization with a gate-based quantum computer. The QAOA consists of a particular ansatz for the quantum circuit architecture, together with a prescription for choosing the variational parameters of the circuit. We propose modifications to both. First, we define the Gibbs objective function and show that it is superior to the energy expectation value for use as an objective function in tuning the variational parameters. Second, we describe an Ansatz Architecture Search (AAS) algorithm for searching the discrete space of quantum circuit architectures near the QAOA to find a better ansatz. Applying these modifications for a complete graph Ising model results in a $244.7\%$ median relative improvement in the probability of finding a low-energy state while using $33.3\%$ fewer two-qubit gates. For Ising models on a 2d grid we similarly find $44.4\%$ median improvement in the probability with a $20.8\%$ reduction in the number of two-qubit gates. This opens a new research field of quantum circuit architecture design for quantum optimization algorithms.

Symbolic regression is a type of discrete optimization problem that involves searching expressions that fit given data points. In many cases, other mathematical constraints about the unknown expression not only provide more information beyond just values at some inputs, but also effectively constrain the search space. We identify the asymptotic constraints of leading polynomial powers as the function approaches zero and infinity as useful constraints and create a system to use them for symbolic regression. The first part of the system is a conditional production rule generating neural network which preferentially generates production rules to construct expressions with the desired leading powers, producing novel expressions outside the training domain. The second part, which we call Neural-Guided Monte Carlo Tree Search, uses the network during a search to find an expression that conforms to a set of data points and desired leading powers. Lastly, we provide an extensive experimental validation on thousands of target expressions showing the efficacy of our system compared to exiting methods for finding unknown functions outside of the training set.

Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drug compounds applied at different doses can be quantified. The general approach is to find a function mapping the images to an embedding space of manageable dimensionality whose geometry captures relevant features of the input images. An important known issue for such methods is separating relevant biological signal from nuisance variation. For example, the embedding vectors tend to be more correlated for cells that were cultured and imaged during the same week than for those from different weeks, despite having identical drug compounds applied in both cases. In this case, the particular batch in which a set of experiments were conducted constitutes the domain of the data; an ideal set of image embeddings should contain only the relevant biological information (e.g. drug effects). We develop a general framework for adjusting the image embeddings in order to `forget' domain-specific information while preserving relevant biological information. To achieve this, we minimize a loss function based on distances between marginal distributions (such as the Wasserstein distance) of embeddings across domains for each replicated treatment. For the dataset we present results with, the only replicated treatment happens to be the negative control treatment, for which we do not expect any treatment-induced cell morphology changes. We find that for our transformed embeddings (i) the underlying geometric structure is not only preserved but the embeddings also carry improved biological signal; and (ii) less domain-specific information is present., Comment: 21 pages, 20 figures, 6 tables

Gaussian random fields have been one of the most popular tools for analyzing spatial data. However, many geophysical and environmental processes often display non-Gaussian characteristics. In this paper, we propose a new class of spatial models for non-Gaussian random fields on a sphere based on a multi-resolution analysis. Using a special wavelet frame, named spherical needlets, as building blocks, the proposed model is constructed in the form of a sparse random effects model. The spatial localization of needlets, together with carefully chosen random coefficients, ensure the model to be non-Gaussian and isotropic. The model can also be expanded to include a spatially varying variance profile. The special formulation of the model enables us to develop efficient estimation and prediction procedures, in which an adaptive MCMC algorithm is used. We investigate the accuracy of parameter estimation of the proposed model, and compare its predictive performance with that of two Gaussian models by extensive numerical experiments. Practical utility of the proposed model is demonstrated through an application of the methodology to a data set of high-latitude ionospheric electrostatic potentials, generated from the LFM-MIX model of the magnetosphere-ionosphere system.

Physical processes that manifest as tangential vector fields on a sphere are common in geophysical and environmental sciences. These naturally occurring vector fields are often subject to physical constraints, such as being curl-free or divergence-free. We construct a new class of parametric models for cross-covariance functions of curl-free and divergence-free vector fields that are tangential to the unit sphere. These models are constructed by applying the surface gradient or the surface curl operator to scalar random potential fields defined on the unit sphere. We propose a likelihood-based estimation procedure for the model parameters and show that fast computation is possible even for large data sets when the observations are on a regular latitude-longitude grid. Characteristics and utility of the proposed methodology are illustrated through simulation studies and by applying it to an ocean surface wind velocity data set collected through satellite-based scatterometry remote sensing. We also compare the performance of the proposed model with a class of bivariate Mat\'ern models in terms of estimation and prediction, and demonstrate that the proposed model is superior in capturing certain physical characteristics of the wind fields.

Compared with the traditional spherical harmonics, the spherical needlets are a new generation of spherical wavelets that possess several attractive properties. Their double localization in both spatial and frequency domains empowers them to easily and sparsely represent functions with small spatial scale features. This paper is divided into two parts. First, it reviews the spherical harmonics and discusses their limitations in representing functions with small spatial scale features. To overcome the limitations, it introduces the spherical needlets and their attractive properties. In the second part of the paper, a Matlab package for the spherical needlets is presented. The properties of the spherical needlets are demonstrated by several examples using the package., Comment: 12 pages, 7 figures, technical report