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4 results on '"Emel Ulupınar"'

1. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Abdurrahim Bakirhan, Safak Yalcin Sahiner, Volkan Sahiner, Şahabettin Çeti̇n, Melike Ceyhan Balcı Şengül, Sema Kuş, Fatih Canan, Ali Erdoğan, Mehmet Murat Kuloğlu, Şengül Şahin, Gülçin Elboğa, Ahmet Zi̇ya Şahin, Ahmet Ünal, Abdurrahman Altındağ, Osman Hasan Tahsin Kılıç, Turkan Dogan, Gonul Kaygisiz, Zeynep Ezgi Bal, Mustafa Solmaz, Derya Adali Aker, Ercan Akin, Samet Kose, Deniz Deniz Özturan, Hatice Özyıldız Güz, Muhammet Emin Naldan, Ali Karayağmurlu, Mehmet Nuri Cevizci, Duygu Kara, Elif Oral Ahiskalioğlu, Pelin Aydın, Yıldız Marangoz, Burcu Akın Sarı, Zeren Barış, Figen Özçay, Başak Tüzün Mutluer, Tuna Güzide Yener Orum, Ebru Şahan, Sencan Sertcelik, Helin Yılmaz, N. Burcu Özbaran, Melis Palamar, Elif Demirkılıç Biler, Ertan Yi̇lmaz, Lut Tamam, Murat Altın, Ipek Fatma Ozaktac, Ayse Sena Sarıdogan, Figen Yavlal, Ceyda Tahincioğlu, Hakan Karaş, Hüseyin Ebadi, Suna Sogucak, Servet Karaca, Murat Kuloglu, Taner Öznur, Abdullah Bolu, Havva Öznur, Serdar Atik, Cemil Çelik, Özcan Uzun, Erol Göka, Tijen Utkan, Tuğçe Demirtaş Şahin, Yusufhan Yazir, Zehra Seda Halbutoğulları, Semil Selcen Gocmez, Feyza Arıcıoğlu, Övgü Sinem Buğan Gülbahar, Abda Mahmood, Enikő Zsoldos, Charlotte L. Allan, Anya Topiwala, Klaus P. Ebmeier, Jung Suk Lee, Jong Hun Kim, Seon-Koo Lee, Gökhan Ünal, Alim Hüseyin Dokumacı, Mükerrem Betül Aycan Yerer, Ceren Özkartal, Hülya Kamarlı Altun, İlkay Keser, Mehmet Mart, Didem Tezcan, Selim Tümkaya, Figen Çulha Ateşci, Cansu Baygın, Çağdaş Öykü Memiş, Bilge Doğan, Levent Sevinçok, Gonca Karakuş, Ceren Şahin Özkartal, Erdem Tüzün, Rümeysa Keleş, Cansu Kandemir, Serap Şirvancı, Cem İsmail Küçükali, Özgür Devrim Can, Umut İrfan Üçel, Ümide Demir Özkay, Emel Ulupınar, Nazlı Turan, Nafiz Öncü Can, Tuğçe Baştaşkın, Canan Yalçınkaya, Gülnaz Arkan, Yusuf Özkay, Serkan Levent, Feyza Alyu, Yusuf Öztürk, Bassem Sadek, Nadia Khan, Dorota Łażewska, Katarzyna Kieć Kononowicz, Mehmet Hamid Boztaş, Derya Arslan, Ayşegül Koç, Derya Öktem Aygün, Hülya Ensari, Ercan Akın, Vedat Ceylan, Mehmet Hakan Turkcapar, Mehmet Yalcin, Hakan Turkcapar, Feryal Cam Celikel, Güzin M Sevinçer, Aysenur Kaya, Suleyman Bozkurt, Nilufer Subasi Tekintas, Fatma Benk Durmus, Kemal Sayar, Fatma Kartal Sarıoğlu, Lale Gönenir Erbay, Rıfat Karlıdağ, Ebru Sekmen, Zeynep Selen Karalök, Zeynep Göker, Esra Çöp, Gülser Dinç, Özlem Hekim Bozkurt, Özden Şükran Üneri, Safinaz Ataoğlu, Handan Ankaralı, Seyit Ankaralı, Büşra Bahar Ataoğlu, Safiye Bahar Ölmez, Esra Çelebi, Özge Pasin, Rumeysa Samancı, Didem Ayyıldız, Neşe Perdahlı Fiş, Hatice Yardi̇m Özayhan, Ali Metehan Çalışkan, İkbal İnanlı, Halil İbrahim Öztürk, Tahsin Etli, İbrahim Eren, Hande Ayraler Taner, Fethiye Kilicaslan, Hamza Ayaydin, Ayca Idil Aytekin, Melek Saka, Sule Aydin, Beyazit Garip, Hakan Kayir, Görkem Karakaş Uğurlu, Mustafa Uğurlu, Ayza Mutlu Haydanlı, Ali Çayköylü, Semra Ulusoy Kaymak, Zuhal Koç Apaydın, Serdar Süleyman Can, Abdullah Bozkurt, Seher Akbaş, Burak Tander, Cengiz Kara, Ünal Bıçakçı, Hamiyet İpek Toz, Özhan Yalçi̇n, Şermin Yalın Sapmaz, Handan Özek Erkuran, Dilay Karaarslan, Masum Öztürk, Gülsüm Yörük Ülker, Burcu Serim Demirgören, Ertuğrul Köroğlu, Ömer Aydemir, Nefize Yalın, Canem Kavurma, Siğnem Öztekin, Birsen Şentürk Pilan, Neslihan Inal Emiroğlu, Dilek Ergin, Nesrin Şen Celasin, Öznur Bilaç, Duygu Kararslan, Mahmut Cem Tarakçıoğlu, Gülşah Acar, Kerime Bademli, Neslihan Lök, Ahmet Zihni Soyata, Mahmut Onur Karaytug, Necla Keskin, Nurgul Ozpoyraz, and Mehmet Emin Demirkol

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2017
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2. High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons

Author

Christopher A. Quintanilla, Zachary Fitzgerald, Omar Kashow, Mihailo S. Radojicic, Emel Ulupinar, Dila Bitlis, Baris Genc, Pavle Andjus, Wim van Drongelen, and P. Hande Ozdinler

Subjects
Medicine, Science
Abstract

Abstract Corticospinal motor neurons (CSMN), located in the motor cortex of the brain, are one of the key components of the motor neuron circuitry. They are in part responsible for the initiation and modulation of voluntary movement, and their degeneration is the hallmark for numerous diseases, such as amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia, and primary lateral sclerosis. Cortical hyperexcitation followed by in-excitability suggests the early involvement of cortical dysfunction in ALS pathology. However, a high-spatiotemporal resolution on our understanding of their functional health and connectivity is lacking. Here, we combine optical imaging with high-density microelectrode array (HD-MEA) system enabling single cell resolution and utilize UCHL1-eGFP mice to bring cell-type specificity to our understanding of the electrophysiological features of healthy CSMN, as they mature and form network connections with other cortical neurons, in vitro. This novel approach lays the foundation for future cell-type specific analyses of CSMN that are diseased due to different underlying causes with cellular precision, and it will allow the assessment of their functional response to compound treatment, especially for drug discovery efforts in upper motor neuron diseases.

Published
2025
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3. Protective effects of anandamide against cisplatin-induced peripheral neuropathy in rats

Author

Çiğdem, Çengelli Ünel, Başak, Ayaz, Şule, Aydın, Emel, Ulupınar, Orhan, Özatik, Bilgin, Kaygısız, Engin, Yıldırım, and Kevser, Erol

Subjects
Rats, Sprague-Dawley, NG-Nitroarginine Methyl Ester, Hyperalgesia, Polyunsaturated Alkamides, Animals, Peripheral Nervous System Diseases, Female, Arachidonic Acids, Cisplatin, Endocannabinoids, Rats
Abstract

Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in vitro effects of AN in CIS neurotoxicity, and the contribution of nitric oxide (NO) in this effect.This is an experimental animal study. Primary dorsal root ganglion (DRG) cultures were prepared from one-day-old rats for in vitro investigations. DRG cells were incubated with CIS (100–300 M), and AN (10, 50, 100, and 500 μM) was administered with the submaximal concentration of CIS. Female Sprague Dawley rats were divided into control, CIS, CIS+AN, CIS+AN+L-NG-nitro arginine methyl ester (LNAME). CIS was administered 3 mg/kg i.p once weekly for 5 weeks. AN (1 mg/kg i.p) or in combination with 10 mg/kg i.p LNAME was administrated 30 min before CIS injection. Mechanical allodynia, thermal hyperalgesia, and tail clip tests were performed. After intracardiac perfusion, sciatic nerves (SN), and DRGs were isolated and semi-thin sections were stained with toluidine blue and investigated histologically. SPSS v. 21.0 and Sigma STAT 3.5 were used for statistical analysis. One/two way ANOVA, Kruskal–Wallis, and Wilcoxon signed ranks tests were used. A p-value of 0.05 was accepted as significant.CIS caused significant mechanical allodynia. AN and AN+LNAME significantly increased hind paw withdrawal latency in mechanical allodynia test. The degenerated axons significantly increased in CIS group, while decreased in AN group. The frequency of larger neurons seemed to be higher in CIS+AN group.AN may be a therapeutic alternative for the treatment of CIS-induced peripheral neuropathy. However, its central adverse effects must be considered.

Published
2021

4. Panels (PS-1 — PS-2)

Author

Emel Ulupınar, Gülgün Şengül, Metehan Çiçek, Tamer Demiralp, Gürkan Öztürk, Ertuğrul Kılıç, Bayram Yılmaz, and Ege Üniversitesi

Subjects
Anatomi ve Morfoloji
Abstract

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Published
2017

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