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1. Prognostic value of cardiovascular magnetic resonance T1 mapping and extracellular volume fraction in nonischemic dilated cardiomyopathy

Author

Cadour, Farah, Quemeneur, Morgane, Biere, Loic, Donal, Erwan, Bentatou, Zakarya, Eicher, Jean-Christophe, Roubille, François, Lalande, Alain, Giorgi, Roch, Rapacchi, Stanislas, Cortaredona, Sébastien, Tradi, Farouk, Bartoli, Axel, Willoteaux, Serge, Delahaye, François, Biene, Stephanie M., Mangin, Lionel, Ferrier, Nadine, Dacher, Jean-Nicolas, Bauer, Fabrice, Leurent, Guillaume, Lentz, Pierre-Axel, Kovacsik, Hélène, Croisille, Pierre, Thuny, Franck, Bernard, Monique, Guye, Maxime, Furber, Alain, Habib, Gilbert, and Jacquier, Alexis

Published
2023
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2. Transthyretin amyloid cardiomyopathy in France: A cross-sectional multi-centre study (333 patients)

Author

Damy, Thibaud, Donal, Erwan, Lairez, Olivier, Eicher, Jean-Christophe, Karoubi, Mounira, Trochu, Jean-Noël, Inamo, Jocelyn, Habib, Gilbert, Roubille, François, Hagège, Albert, Morio, Flore, Cariou, Eve, Adda, Jérôme, Algalarrondo, Vincent, Coste, Agathe, Bartoli, Mathilde, Rudant, Jérémie, Salvi, Lara, Francou, Bruno, Guiochon-Mantel, Anne, Adams, David, Antoine, Jean-Christophe, Attarian, Shahram, Cintas, Pascal, Morales, Raul Juntas, Lagrange, Emmeline, Magy, Laurent, Mallaret, Martial, Péréon, Yann, Petiot, Philippe, Cauquil, Cécile, Labeyrie, Céline, Echaniz-Laguna, Andoni, Sole, Guilhem, Tard, Céline, Oghina, Silvia, Charron, Philippe, and Slama, Michel

Published
2024
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3. Exercise-Induced Left Atrial Hypertension in Heart Failure With Preserved Ejection Fraction

Author

Litwin, Sheldon E., Komtebedde, Jan, Hu, Mo, Burkhoff, Daniel, Hasenfuß, Gerd, Borlaug, Barry A., Solomon, Scott D., Zile, Michael R., Mohan, Rajeev C., Khawash, Rami, Sverdlov, Aaron L., Fail, Peter, Chung, Eugene S., Kaye, David M., Blair, John, Eicher, Jean-Christophe, Hummel, Scott L., Zirlik, Andreas, Westenfeld, Ralf, Hayward, Christopher, Gorter, Thomas M., Demers, Catherine, Shetty, Ranjith, Lewis, Gregory, Starling, Randall C., Patel, Sanjay, Gupta, Deepak K., Morsli, Hakim, Penicka, Martin, Cikes, Maja, Gustafsson, Finn, Silvestry, Frank E., Rowin, Ethan J., Cutlip, Donald E., Leon, Martin B., Kitzman, Dalane W., Kleber, Franz X., and Shah, Sanjiv J.

Published
2023
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9. Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia

Author

Chirouze, Catherine, Curlier, Elodie, Descottes-Genon, Cécile, Hoen, Bruno, Patry, Isabelle, Vettoretti, Lucie, Chavanet, Pascal, Eicher, Jean-Christophe, Gohier-Treuvelot, Sandrine, Greusard, Marie-Christine, Neuwirth, Catherine, Péchinot, André, Piroth, Lionel, Célard, Marie, Cornu, Catherine, Delahaye, François, Hadid, Malika, Rausch, Pascale, Coma, Audrey, Galtier, Florence, Géraud, Philippe, Jean-Pierre, Hélène, Le Moing, Vincent, Sportouch, Catherine, Reynes, Jacques, Aissa, Nejla, Doco-Lecompte, Thanh, Goehringer, François, Keil, Nathalie, Letranchant, Lorraine, Malela, Hepher, May, Thierry, Selton-Suty, Christine, Bedos, Nathalie, Lavigne, Jean-Philippe, Lechiche, Catherine, Sotto, Albert, Duval, Xavier, Habensus, Emila Ilic, Iung, Bernard, Leport, Catherine, Longuet, Pascale, Ruimy, Raymond, Bellissant, Eric, Donnio, Pierre-Yves, Le Gac, Fabienne, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Thebault, Elise, Alla, François, Braquet, Pierre, Erpelding, Marie-Line, Minary, Laetitia, Tubiana, Sarah, Bès, Michèle, Etienne, Jérôme, Lelekov-Boissard, Taissia, Tristan, Anne, Vandenesch, François, Van Belkum, Alex, Rivadeneira, Fernando, Vanwamel, Willem, Barbas, Sandrine, Delonca, Christine, Sussmuth, Virginie, Verchère, Anne, Siméon, S., Le Moing, V., Tubiana, S., Duval, X., Fournier, D., Lavigne, J.-P., Erpelding, M.-L., Gustave, C.-A., Desage, S., Chirouze, C., Vandenesch, F., and Tattevin, P.

Published
2019
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10. Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP‐HF II trial.

Author

Litwin, Sheldon E., Komtebedde, Jan, Seidler, Tim, Borlaug, Barry A., Winkler, Sebastian, Solomon, Scott D., Eicher, Jean‐Christophe, Mazimba, Sula, Khawash, Rami, Sverdlov, Aaron L., Hummel, Scott L., Bugger, Heiko, Boenner, Florian, Hoendermis, Elke, Cikes, Maja, Demers, Catherine, Silva, Guillherme, van Empel, Vanessa, Starling, Randall C., and Penicka, Martin

Subjects
VENTRICULAR ejection fraction, HEART failure, OBESITY, VASCULAR resistance, CARDIAC output, BODY mass index
Abstract

Aims: Obesity is causally related to the development of heart failure with preserved ejection fraction (HFpEF) but complicates the diagnosis and treatment of this disorder. We aimed to determine the relationship between severity of obesity and clinical, echocardiographic and haemodynamic parameters in a large cohort of patients with documented HFpEF. Methods and results: The REDUCE LAP‐HF II trial randomized 626 patients with ejection fraction ≥40% and exercise pulmonary capillary wedge pressure (PCWP) ≥25 mmHg to atrial shunt or sham procedure. We tested for associations between body mass index (BMI), clinical characteristics, cardiac structural and functional abnormalities, physical limitations, quality of life and outcomes with atrial shunt therapy. Overall, 60.9% of patients had BMI ≥30 kg/m2. As the severity of obesity increased, symptoms (Kansas City Cardiomyopathy Questionnaire score) and 6‐min walk distance worsened. More severe obesity was associated with lower natriuretic peptide levels despite more cardiac remodelling, higher cardiac filling pressures, and higher cardiac output. Lower cut points for E/e′ were needed to identify elevated PCWP in more obese patients. Strain measurements in all four chambers were maintained as BMI increased. Pulmonary vascular resistance at rest and exercise decreased with higher BMI. Obesity was associated with more first and recurrent heart failure events. However, there was no significant interaction between obesity and treatment effects of the atrial shunt. Conclusions: Increasing severity of obesity was associated with greater cardiac remodelling, higher right and left ventricular filling pressures, higher cardiac output and increased subsequent heart failure events. Despite significant obesity, many HFpEF patients have preserved right heart and pulmonary vascular function and thus, may be appropriate candidates for atrial shunt therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure

Author

Borlaug, Barry A., Blair, John, Bergmann, Martin W., Bugger, Heiko, Burkhoff, Dan, Bruch, Leonhard, Celermajer, David S., Claggett, Brian, Cleland, John G. F., Cutlip, Donald E., Dauber, Ira, Eicher, Jean-Christophe, Gao, Qi, Gorter, Thomas M., Gustafsson, Finn, Hayward, Chris, Van der Heyden, Jan, Hasenfuß, Gerd, Hummel, Scott L., Kaye, David M., Komtebedde, Jan, Massaro, Joseph M., Mazurek, Jeremy A., McKenzie, Scott, Mehta, Shamir R., Petrie, Mark C., Post, Marco C., Nair, Ajith, Rieth, Andreas, Silvestry, Frank E., Solomon, Scott D., Trochu, Jean-Noël, Veldhuisen, Dirk J. Van, Westenfeld, Ralf, Leon, Martin B., Shah, Sanjiv J., and Cardiovascular Centre (CVC)

Subjects
Male, Cardiac Catheterization, Pulmonary Circulation, hypertension, pulmonary, hypertension, pulmonary, heart failure, EXERCISE, PRESSURE, Article, Physiology (medical), therapeutics, Humans, Heart Atria, lung diseases, OUTCOMES, REST, Stroke Volume, clinical trial, TIME, Treatment Outcome, PRESERVED EJECTION FRACTION, Female, vascular diseases, Cardiology and Cardiovascular Medicine, INTERATRIAL SHUNT
Abstract

Background: In REDUCE LAP-HF II (A Study to Evaluate the Corvia Medical, Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients With Heart Failure), implantation of an atrial shunt device did not provide overall clinical benefit for patients with heart failure with preserved or mildly reduced ejection fraction. However, prespecified analyses identified differences in response in subgroups defined by pulmonary artery systolic pressure during submaximal exercise, right atrial volume, and sex. Shunt implantation reduces left atrial pressures but increases pulmonary blood flow, which may be poorly tolerated in patients with pulmonary vascular disease (PVD). On the basis of these results, we hypothesized that patients with latent PVD, defined as elevated pulmonary vascular resistance during exercise, might be harmed by shunt implantation, and conversely that patients without PVD might benefit. Methods: REDUCE LAP-HF II enrolled 626 patients with heart failure, ejection fraction ≥40%, exercise pulmonary capillary wedge pressure ≥25 mm Hg, and resting pulmonary vascular resistance Results: Compared with patients without PVD (n=382), those with latent PVD (n=188) were older, had more atrial fibrillation and right heart dysfunction, and were more likely to have elevated left atrial pressure at rest. Shunt treatment was associated with worse outcomes in patients with PVD (win ratio, 0.60 [95% CI, 0.42, 0.86]; P =0.005) and signal of clinical benefit in patients without PVD (win ratio, 1.31 [95% CI, 1.02, 1.68]; P =0.038). Patients with larger right atrial volumes and men had worse outcomes with the device and both groups were more likely to have pacemakers, heart failure with mildly reduced ejection fraction, and increased left atrial volume. For patients without latent PVD or pacemaker (n=313; 50% of randomized patients), shunt treatment resulted in more robust signal of clinical benefit (win ratio, 1.51 [95% CI, 1.14, 2.00]; P =0.004). Conclusions: In patients with heart failure with preserved or mildly reduced ejection fraction, the presence of latent PVD uncovered by invasive hemodynamic exercise testing identifies patients who may worsen with atrial shunt therapy, whereas those without latent PVD may benefit.

Published
2022

12. Feasibility and accuracy of linking a heart failure registry to the national claims database using indirect identifiers

Author

Logeart, Damien, primary, Damy, Thibaud, additional, Doublet, Maxime, additional, Salvat, Muriel, additional, Tribouilloy, Christophe, additional, Bauer, Fabrice, additional, Eicher, Jean-Christophe, additional, Picard, François, additional, Roul, Gérald, additional, Trochu, Jean-Noël, additional, De Groote, Pascal, additional, Bihry, Nicolas, additional, Berthelot, Emmanuelle, additional, Jondeau, Guillaume, additional, Seronde, Marie-France, additional, Roubille, François, additional, and Isnard, Richard, additional

Published
2023
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13. Impact of the First COVID-19 Wave on French Hospitalizations for Myocardial Infarction and Stroke: A Retrospective Cohort Study

Author

Mariet, Anne-Sophie, primary, Duloquin, Gauthier, additional, Benzenine, Eric, additional, Roussot, Adrien, additional, Pommier, Thibaut, additional, Eicher, Jean-Christophe, additional, Baptiste, Laura, additional, Giroud, Maurice, additional, Cottin, Yves, additional, Béjot, Yannick, additional, and Quantin, Catherine, additional

Published
2022
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14. Therapeutic inertia in the pharmacological management of heart failure with reduced ejection fraction

Author

Girerd, Nicolas, Von Hunolstein, Jean-Jacques, Pellicori, Pierpaolo, Bayés-Genís, Antoni, Jaarsma, Tiny, Lund, Lars H., Bilbault, Pascal, Boivin, Jean-Marc, Chouihed, Tahar, Costa, Jérôme, Eicher, Jean-Christophe, Fall, Estelle, Kenizou, David, Maillier, Bruno, Nazeyrollas, Pierre, Roul, Gérald, Zannad, Noura, Rossignol, Patrick, and Seronde, Marie-France

Subjects
Heart Failure, Ventricular Dysfunction, Left, Kardiologi, Humans, Cardiac and Cardiovascular Systems, Stroke Volume, Cardiology and Cardiovascular Medicine
Abstract

No abstract available.

Published
2022

15. Smoking in Patients With Chronic Cardiovascular Disease During COVID-19 Lockdown

Author

Chagué, Frédéric, Boulin, Mathieu, Eicher, Jean-Christophe, Bichat, Florence, Saint-Jalmes, Maïlis, Cransac, Amélie, Soudry, Agnès, Danchin, Nicolas, Laurent, Gabriel, Cottin, Yves, and Zeller, Marianne

Subjects
Cardiology and Cardiovascular Medicine
Abstract

ObjectivesThis cross-sectional study aims to investigate health-related behaviors including tobacco consumption among patients with cardiovascular diseases (CVD), during the first COVID-19-related lockdown.MethodsAfter 5 weeks of COVID-19 lockdown, 220 patients with chronic coronary syndromes (CCS) and 124 with congestive heart failure (CHF) answered a phone questionnaire.ResultsAmong these 344 patients, 43 (12.5%) were current smokers, and none had quit during the lockdown. When compared with non-smokers, smokers were 15 years younger, more often diabetic, more likely to live in an urban than a rural lockdown location, and more often in the CCS cohort (p = 0.011). Smokers described greater psychological impairment, but their rates of decrease in physical activity and of increase in screen time were similar to non-smokers. More than one-third (13/43) increased their tobacco consumption, which was mainly related to stress or boredom, but not driven by media messages on a protective effect of nicotine.ConclusionsDuring the first COVID-19 lockdown, we found a decrease in favorable lifestyle behaviors among patients with CVD. Strikingly, one-third of smokers with CCS or CHF increased their tobacco consumption. Given the major impact of persistent smoking in patients with CVD, this highlights the need for targeted prevention strategies, in particular during such periods.

Published
2022

16. Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II):a randomised, multicentre, blinded, sham-controlled trial

Author

Shah, Sanjiv J., Borlaug, Barry A., Chung, Eugene, Cutlip, Donald E., Debonnaire, Philippe, Fail, Peter, Gao, Qi, Hasenfuß, Gerd, Kahwash, Rami, Kaye, David M., Litwin, Sheldon E., Lurz, Philipp, Massaro, Joseph M., Mohan, Rajeev C., Ricciardi, Mark J., Solomon, Scott D., Sverdlov, Aaron L., Swarup, Vijendra, van Veldhuisen, Dirk J., Winkler, Sebastian, Leon, Martin B., Akar, Joseph, Ando, Jiro, Anzai, Toshihisa, Asakura, Masanori, Bailey, Steven, Basuray, Anupam, Bauer, Fabrice, Bergmann, Martin, Blair, John, Cavendish, Jeffrey, Cikes, Maja, Dauber, Ira, Donal, Erwan, Eicher, Jean Christophe, Flaherty, James, Freixa, Xavier, Gafoor, Sameer, Gertz, Zachary, Gordon, Robert, Guazzi, Marco, Guerrero-Miranda, Cesar, Gupta, Deepak, Gustafsson, Finn, Hadadi, Cyrus, Hakemi, Emad, Handoko, Louis, Hass, Moritz, Shah, Sanjiv J., Borlaug, Barry A., Chung, Eugene, Cutlip, Donald E., Debonnaire, Philippe, Fail, Peter, Gao, Qi, Hasenfuß, Gerd, Kahwash, Rami, Kaye, David M., Litwin, Sheldon E., Lurz, Philipp, Massaro, Joseph M., Mohan, Rajeev C., Ricciardi, Mark J., Solomon, Scott D., Sverdlov, Aaron L., Swarup, Vijendra, van Veldhuisen, Dirk J., Winkler, Sebastian, Leon, Martin B., Akar, Joseph, Ando, Jiro, Anzai, Toshihisa, Asakura, Masanori, Bailey, Steven, Basuray, Anupam, Bauer, Fabrice, Bergmann, Martin, Blair, John, Cavendish, Jeffrey, Cikes, Maja, Dauber, Ira, Donal, Erwan, Eicher, Jean Christophe, Flaherty, James, Freixa, Xavier, Gafoor, Sameer, Gertz, Zachary, Gordon, Robert, Guazzi, Marco, Guerrero-Miranda, Cesar, Gupta, Deepak, Gustafsson, Finn, Hadadi, Cyrus, Hakemi, Emad, Handoko, Louis, and Hass, Moritz

Abstract

Background: Placement of an interatrial shunt device reduces pulmonary capillary wedge pressure during exercise in patients with heart failure and preserved or mildly reduced ejection fraction. We aimed to investigate whether an interatrial shunt can reduce heart failure events or improve health status in these patients. Methods: In this randomised, international, blinded, sham-controlled trial performed at 89 health-care centres, we included patients (aged ≥40 years) with symptomatic heart failure, an ejection fraction of at least 40%, and pulmonary capillary wedge pressure during exercise of at least 25 mm Hg while exceeding right atrial pressure by at least 5 mm Hg. Patients were randomly assigned (1:1) to receive either a shunt device or sham procedure. Patients and outcome assessors were masked to randomisation. The primary endpoint was a hierarchical composite of cardiovascular death or non-fatal ischemic stroke at 12 months, rate of total heart failure events up to 24 months, and change in Kansas City Cardiomyopathy Questionnaire overall summary score at 12 months. Pre-specified subgroup analyses were conducted for the heart failure event endpoint. Analysis of the primary endpoint, all other efficacy endpoints, and safety endpoints was conducted in the modified intention-to-treat population, defined as all patients randomly allocated to receive treatment, excluding those found to be ineligible after randomisation and therefore not treated. This study is registered with ClinicalTrials.gov, NCT03088033. Findings: Between May 25, 2017, and July 24, 2020, 1072 participants were enrolled, of whom 626 were randomly assigned to either the atrial shunt device (n=314) or sham procedure (n=312). There were no differences between groups in the primary composite endpoint (win ratio 1·0 [95% CI 0·8–1·2]; p=0·85) or in the individual components of the primary endpoint. The prespecified subgroups demonstrating a differential effect of atrial shunt device treatment on hea

Published
2022

17. Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study

Author

Gerard, Hilla, primary, Iline, Nicolas, additional, Martel, Hélène, additional, Nguyen, Karine, additional, Richard, Pascale, additional, Donal, Erwan, additional, Eicher, Jean-Christophe, additional, Huttin, Olivier, additional, Selton-Suty, Christine, additional, Raud-Raynier, Pascale, additional, Jondeau, Guillaume, additional, Mansencal, Nicolas, additional, Sawka, Caroline, additional, Ader, Flavie, additional, Pruny, Jean-François, additional, Casalta, Anne-Claire, additional, Michel, Nicolas, additional, Donghi, Valeria, additional, Faivre, Laurence, additional, Giorgi, Roch, additional, Charron, Philippe, additional, and Habib, Gilbert, additional

Published
2022
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18. COVID-19 Lockdown in Patients with Chronic Diseases: A Cross-Sectional Study

Author

Boulin, Mathieu, primary, Cransac-Miet, Amélie, additional, Maynadié, Marc, additional, Volot, Fabienne, additional, Creuzot-Garcher, Catherine, additional, Eicher, Jean-Christophe, additional, Chagué, Frédéric, additional, Ksiazek, Eléa, additional, Beltramo, Guillaume, additional, Bonniaud, Philippe, additional, Moreau, Thibault, additional, Bonnotte, Bernard, additional, Sales-Wuillemin, Edith, additional, Soudry-Faure, Agnès, additional, Zeller, Marianne, additional, and Cottin, Yves, additional

Published
2022
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19. Telemonitoring versus standard care in heart failure: a randomised multicentre trial

Author

Galinier, Michel, Roubille, François, Berdagué, Philippe, Brierre, Gilles, Cantie, Philippe, Dary, Patrick, Ferradou, Jean‐Marc, Fondard, Olivier, Labarre, Jean Philippe, Mansourati, Jacques, Picard, François, Ricci, Jean‐Etienne, Salvat, Muriel, Tartière, Lamia, Ruidavets, Jean‐Bernard, Bongard, Vanina, Delval, Cécile, Lancman, Guila, Pasche, Hélène, Ramirez‐Gil, Juan Fernando, Pathak, Atul, Machecourt, Jacques, Valeix, Bernard, Royer, Thierry, Louvard, Yves, Aboyans, Victor, Beard, Thierry, Cheggour, Saïda, Cottin, Yves, Delarche, Nicolas, Eicher, Jean‐Christophe, Faure, Antoine, Gibelin, Pierre, Gosse, Philippe, Inamo, Jocelyn, Lescure‐Ducay, Maryse, Litalien, Jean, Milhau, Sabine, Pouchelon, Elisabeth, Prunier, Fabrice, Salloum, Antoine, Aloun, Jocelyn Souk, Tartière, Jean‐Michel, Taudou, Marie‐José, Thuny, Franck, Tribouilloy, Christophe, Service de cardiologie [Toulouse], Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), MSP Beziers, Centre Hospitalier de Beziers, Centre Hospitalier Intercommunal Castres-Mazamet, Clinique Pasteur [Toulouse], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Toulouse [Toulouse], Air Liquide Santé International, Service de Pharmacologie Clinique, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], CHU Limoges, Service de Cardiologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre hospitalier de Pau, Hôpital Pasteur [Nice] (CHU), Hôpital Saint-André, Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Laboratoire de Protection et Remodelage du Myocarde (PMRM), Université d'Angers (UA)-Université d'Angers (UA), Hôpital Sainte-Musse, Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de Cardiologie [Amiens], CHU Amiens-Picardie, Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service Pharmacologie Clinique [CHU Toulouse], and Pôle Santé publique et médecine publique [CHU Toulouse]

Subjects
Male, Relative risk reduction, Telemonitoring, medicine.medical_specialty, Class iii, 030204 cardiovascular system & hematology, Rate ratio, 03 medical and health sciences, 0302 clinical medicine, Primary outcome, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Standard care, Internal medicine, Hospitalisation, medicine, Humans, Editorial Comments, Aged, Aged, 80 and over, Heart Failure, business.industry, Hazard ratio, Standard of Care, Patient education, Body weight, Middle Aged, medicine.disease, Telemedicine, Confidence interval, 3. Good health, Hospitalization, Heart failure, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Cardiology and Cardiovascular Medicine, business, Editorial Comment
Abstract

International audience; Aims: The aim was to assess the effect of a telemonitoring programme vs. standard care (SC) in preventing all‐cause deaths or unplanned hospitalisations in heart failure (HF) at 18 months.Methods and results: OSICAT was a randomised, multicentre, open‐label French study in 937 patients hospitalised for acute HF ≤12 months before inclusion. Patients were randomised to telemonitoring (daily body weight measurement, daily recording of HF symptoms, and personalised education) (n = 482) or to SC (n = 455). Mean ± standard deviation number of events for the primary outcome was 1.30 ± 1.85 for telemonitoring and 1.46 ± 1.98 for SC [rate ratio 0.97, 95% confidence interval (CI) 0.77–1.23; P = 0.80]. In New York Heart Association (NYHA) class III or IV HF, median time to all‐cause death or first unplanned hospitalisation was 82 days in the telemonitoring group and 67 days in the SC group (P = 0.03). After adjustment for known predictive factors, telemonitoring was associated with a 21% relative risk reduction in first unplanned hospitalisation for HF [hazard ratio (HR) 0.79, 95% CI 0.62–0.99; P = 0.044); the relative risk reduction was 29% in patients with NYHA class III or IV HF (HR 0.71, 95% CI 0.53–0.95; P = 0.02), 38% in socially isolated patients (HR 0.62, 95% CI 0.39–0.98; P = 0.043), and 37% in patients who were ≥70% adherent to body weight measurement (HR 0.63, 95% CI 0.45–0.88; P = 0.006).Conclusion: Telemonitoring did not result in a significantly lower rate of all‐cause deaths or unplanned hospitalisations in HF patients. The pre‐specified subgroup results suggest the telemonitoring approach improves clinical outcomes in selected populations but need further confirmation.

Published
2020

22. Prevalence and clinical phenotype of hereditary transthyretin amyloid cardiomyopathy in patients with increased left ventricular wall thickness

Author

Damy, Thibaud, Costes, Bruno, Hagège, Albert A., Donal, Erwan, Eicher, Jean-Christophe, Slama, Michel, Guellich, Aziz, Rappeneau, Stéphane, Gueffet, Jean-Pierre, Logeart, Damien, Planté-Bordeneuve, Violaine, Bouvaist, Hélène, Huttin, Olivier, Mulak, Geneviève, Dubois-Randé, Jean-Luc, Goossens, Michel, Canoui-Poitrine, Florence, and Buxbaum, Joel N.

Published
2016
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24. Cardiovascular outcomes after cardiac resynchronization therapy in cardiac amyloidosis

Author

Fischer, Kilian, primary, Lellouche, Nicolas, additional, Damy, Thibaud, additional, Martins, Raphaël, additional, Clementy, Nicolas, additional, Bisson, Arnaud, additional, Lesaffre, François, additional, Espinosa, Madeline, additional, Garcia, Rodrigue, additional, Degand, Bruno, additional, Serzian, Guillaume, additional, Jourda, François, additional, Huttin, Olivier, additional, Guichard, Jean‐Baptiste, additional, Devilliers, Hervé, additional, Eicher, Jean‐Christophe, additional, Laurent, Gabriel, additional, and Guenancia, Charles, additional

Published
2021
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25. Temporal Relationship between Atrial Fibrillation and Heart Failure Development Analysis from a Nationwide Database

Author

Cottin, Yves, primary, Maalem Ben Messaoud, Brahim, additional, Monin, Antoine, additional, Guilleminot, Pierre, additional, Bisson, Arnaud, additional, Eicher, Jean-Christophe, additional, Bodin, Alexandre, additional, Herbert, Julien, additional, Juillière, Yves, additional, Zeller, Marianne, additional, and Fauchier, Laurent, additional

Published
2021
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26. Early and short‐term intensive management after discharge for patients hospitalized with acute heart failure: a randomized study (ECAD‐HF)

Author

Logeart, Damien, primary, Berthelot, Emmannuelle, additional, Bihry, Nicolas, additional, Eschalier, Romain, additional, Salvat, Muriel, additional, Garcon, Philippe, additional, Eicher, Jean‐Christophe, additional, Cohen, Ariel, additional, Tartiere, Jean‐Michel, additional, Samadi, Alireza, additional, Donal, Erwan, additional, deGroote, Pascal, additional, Mewton, Nathan, additional, Mansencal, Nicolas, additional, Raphael, Pierre, additional, Ghanem, Nachwan, additional, Seronde, Marie‐France, additional, Chavelas, Christophe, additional, Rosamel, Yann, additional, Beauvais, Florence, additional, Kevorkian, Jean‐Philippe, additional, Diallo, Abdourahmane, additional, Vicaut, Eric, additional, and Isnard, Richard, additional

Published
2021
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27. Factors associated with 12 week case-fatality in Staphylococcus aureus bacteraemia: a prospective cohort study

Author

Chirouze, Catherine, Curlier, Elodie, Descottes-Genon, Cécile, Hoen, Bruno, Patry, Isabelle, Vettoretti, Lucie, Chavanet, Pascal, Eicher, Jean-Christophe, Greusard, Marie-Christine, Neuwirth, Catherine, Péchinot, André, Piroth, Lionel, Célard, Marie, Cornu, Catherine, Delahaye, François, Hadid, Malika, Rausch, Pascale, Coma, Audrey, Galtier, Florence, Géraud, Philippe, Jean-Pierre, Hélène, Le Moing, Vincent, Sportouch, Catherine, Reynes, Jacques, Aissa, Nejla, Doco-Lecompte, Thanh, Goehringer, François, Keil, Nathalie, Letranchant, Lorraine, Malela, Hepher, May, Thierry, Selton-Suty, Christine, Bedos, Nathalie, Lavigne, Jean-Philippe, Lechiche, Catherine, Sotto, Albert, Duval, Xavier, Habensus, Emila Ilic, Iung, Bernard, Leport, Catherine, Longuet, Pascale, Ruimy, Raymond, Bellissant, Eric, Donnio, Pierre-Yves, Le Gac, Fabienne, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Thebault, Elise, Alla, François, Braquet, Pierre, Erpelding, Marie-Line, Minary, Laetitia, Bès, Michèle, Etienne, Jérôme, Tristan, Anne, Vandenesch, François, Van Belkum, Alex, Vanwamel, Willem, Braquet, P., Alla, F., Cornu, C., Goehringer, F., Piroth, L., Chirouze, C., Revest, M., Lechiche, C., Duval, X., and Le Moing, V.

Published
2016
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28. First symptoms and health care pathways in hospitalized patients with acute heart failure: ICPS2 survey. A report from the Heart Failure Working Group (GICC) of the French Society of Cardiology

Author

Beauvais, Florence, primary, Tartière, Lamia, additional, Pezel, Théo, additional, Motet, Chloé, additional, Aumont, Marie‐Claude, additional, Baudry, Guillaume, additional, Eicher, Jean‐Christophe, additional, Galinier, Michel, additional, Gellen, Barnabas, additional, Guihaire, Julien, additional, Legallois, Damien, additional, Lequeux, Benoit, additional, Mika, Delphine, additional, Mouquet, Frederic, additional, Salvat, Muriel, additional, Taieb, Charles, additional, Zorès, Florian, additional, Berthelot, Emmanuelle, additional, and Damy, Thibaud, additional

Published
2021
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30. Natural history of functional tricuspid regurgitation: impact of cardiac output

Author

Chen, Elisabeth, primary, L’official, Guillaume, additional, Guérin, Anne, additional, Dreyfus, Julien, additional, Lavie-Badie, Yoan, additional, Sportouch, Catherine, additional, Eicher, Jean-Christophe, additional, Maréchaux, Sylvestre, additional, Le Tourneau, Thierry, additional, Oger, Emmanuel, additional, and Donal, Erwan, additional

Published
2021
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31. Current aspects of the spectrum of acute heart failure syndromes in a real-life setting: the OFICA study

Author

Logeart, Damien, Isnard, Richard, Resche-Rigon, Matthieu, Seronde, Marie-France, de Groote, Pascal, Jondeau, Guillaume, Galinier, Michel, Mulak, Geneviève, Donal, Erwan, Delahaye, François, Juilliere, Yves, Damy, Thibaud, Jourdain, Patrick, Bauer, Fabrice, Eicher, Jean-Christophe, Neuder, Yannick, Trochu, Jean-Noël, Chantal, Ache Papillon, Nadia, Aissaoudi, François, Aupetit Jean, Christian, Baietto, Noël, Baille, Serge, Baleynaud, Jacques, Ballout, Claude, Barnay, Fabrice, Bauer, Bechetoille, Mohammed, Belhameche, Loïc, Belle, Sandrine, Bentzinger, Alain, Bergere, Philippe, Bernadet, Marie, Perron Jean, François, Bernasconi, Samia, Berranen, Annick, Bineau-Jorisse, Michel, Serrano, Christian, Boureux, Salim, Boutalba, Erik, Bouvier, Marc, Bouvier Jean, Françoise, Bragard Marie, Philippe, Brunel, Roland, Carlioz, Christophe, Charniot Jean, Christophe, Chavelas, Saïda, Cheggour, Pascal, Chevalet, Vlad, Ciobotaru, René, Codjia, Alain, Cohen Solal, Patrick, Coulon, Daniel, Czitrom, Nicolas, Dahdal, Philippe, De Corbiere, Pascal, De Groote, Olivier, De Sauniere, France, Deforet Marie, Alain, Lassabe, Michel, Mansour, François, Delahaye, Michel, Chuzeville, Arnaud, Dellinger, Jacques, Denis, Gilles, Dentan, Michèle, Desruennes, Sylvain, Destrac, Claude, Dib Jean, Rodies, Dimitriou, Philippe, Doazan Jean, Erwan, Donal, Pierre, Matali, Pierre, Dos Santos, Roland, Sananes, Jacques, Dujardin Jean, Hervé, Gallois, Eric, Durand, Michel, Desnos, Sophie, Durand, Florence, Durup, Laurent, Dutoit, J-C, Eicher, Abdellatif, El Hallak, Mariam, Elkohen, Elodie, Faveau, Michèle, Escande, Jean, Ettori, Laurent, Fauchier, François, Maillot, Jean-Pierre, Favier, Bertrand, Fontan, Patrick, Friocourt, Philippe, Fromage, Michel, Galinier, Daniel, Galley, Erik, Garbarz, Philippe, Garcon, Daniel, Garnier, Cédric, Gaxatte, Frédéric, Georger, Renaud, Gervais, Nachwan, Ghanem, Géraldine, Gibault, Clément, Charbonnel, Pierre, Gibelin, Patrice, Brocker, Michel, Gofard, Mohand, Goudjil, Gilbert, Habib, Maryline, Hamdan-Challe, Olivier, Hanon, Michèle, Pinson, Luc, Hittinger, David, Houpe, Agnes, Hyverts, Eva, Inorowicz, Richard, Isnard, Adi, Issa, Muntaser P, Jamal, Luc, Jannin-Manificat, Guillaume, Jondeau, Patrick, Jourdain, Marc, Joussen Jean, Alain, Juillard, Yves, Juilliere, David, Kenizou, Barbara, Lambert, Skander, Khechine, Robin, Zelinsky, Pierre, Lagorce, Maryse, Lescure, Pierre, Lantelme, Thierry, Laperche, Fabrice, Larrazet, Evelyne, Laurent, Philippe, Le Metayer, Patrick, Assyag, Julien, Lemoine, Rémy, Lepori, Benoit, Lequeux, Guillaume, Lhernault, Christine, Machuron, Dominique, Magnin, Nam, Mai, Hamid, Makki, Mounia, Malou, J Jacques, Marier, Jean-Pierre, Maroni, Michel, Martelet, Colette, Matagrin, Nicolas, Coquerel, Mestre-Fernandes, Damien, Metz, Christophe, Meune, Laurent, Michel, Sandrine, Migran, Olivier, Milleron, Catherine, Mimran, Christian, Montagnier, Christophe, Moreau, Yannick, Neuder, Laurent, Orion, Blandine, Ouattara, Joël, Belmin, Eric, Perchicot, Sandrine, Peyrot, Laurent, Poirette, Philippe, Pon-Gabrielsen, Isabelle, Poulain, Fabrice, Prunier, Mamy, Randriamora, Pierre, Raphael, Charles, Raynaud Jean, Guy, Rebuffat, Michel, Remond, Franck, Revel, François, Roubille, Rémi, Sabatier, Raïf, Sader, Robert, Sal, Carole, Saudubray, France, Seronde Marie, François-Xavier, Soto, Jocelyn, Souk Aloun, Benoit, Spillemaecker, Adel, Srour, Yves, Tabet Jean, Michel, Tartiere Jean, Guy, Thourot, Thierry, Tibi, Christophe, Tribouilloy, Noël, Trochu Jean, Eric, Verbrugge, François, Vinchon, and Khelil, Yaici

Published
2013
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37. Cardiovascular outcomes after cardiac resynchronization therapy in cardiac amyloidosis.

Author

Fischer, Kilian, Lellouche, Nicolas, Damy, Thibaud, Martins, Raphaël, Clementy, Nicolas, Bisson, Arnaud, Lesaffre, François, Espinosa, Madeline, Garcia, Rodrigue, Degand, Bruno, Serzian, Guillaume, Jourda, François, Huttin, Olivier, Guichard, Jean‐Baptiste, Devilliers, Hervé, Eicher, Jean‐Christophe, Laurent, Gabriel, and Guenancia, Charles

Subjects
CARDIAC pacing, CARDIAC amyloidosis
Abstract

Aims: Cardiac resynchronization therapy (CRT) is highly effective in dilated cardiomyopathy (DCM) patients with impaired left ventricular ejection fraction (LVEF) and left bundle block branch. In cardiac amyloidosis (CA) patients, left ventricular dysfunction and conduction defects are common, but the potential of CRT to improve cardiac remodelling and survival in this particular setting remains undefined. We investigated cardiovascular outcomes in CA patients after CRT implantation in terms of CRT echocardiographic response and major cardiovascular events (MACEs). Methods and results: Our retrospective study included 47 CA patients implanted with CRT devices from January 2012 to February 2020, in nine French university hospitals (77 ± 6 years old, baseline LVEF 30 ± 8%) compared with propensity‐matched (1:1 for age, LVEF at implantation, and CRT indication) DCM patients with a CRT device. CA patients had lower rates of CRT response (absolute delta LVEF ≥ 10%) compared with DCM patients (36% vs. 70%, P = 0.002). After multivariate Cox analysis, CA was independently associated with MACE (hospitalization for heart failure/cardiovascular death) [hazard ratio (HR) 3.73, 95% confidence interval (CI) 1.85–7.54, P < 0.001], along with the absence of CRT response (HR 3.01, 95% CI 1.56–5.79, P = 0.001). The presence of echocardiographic CRT response (absolute delta LVEF ≥ 10%) was the only predictive factor of MACE‐free survival in CA patients (HR 0.36, 95% CI 0.15–0.86, P = 0.002). Conclusion: Compared with a matched cohort of DCM patients, CA patients had a lower rate of CRT response and consequently a worse cardiovascular prognosis after CRT implantation. However, CRT could be beneficial even in CA patients given that CRT response was associated with better cardiac outcomes in this population. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Early and short‐term intensive management after discharge for patients hospitalized with acute heart failure: a randomized study (ECAD‐HF).

Author

Logeart, Damien, Berthelot, Emmannuelle, Bihry, Nicolas, Eschalier, Romain, Salvat, Muriel, Garcon, Philippe, Eicher, Jean‐Christophe, Cohen, Ariel, Tartiere, Jean‐Michel, Samadi, Alireza, Donal, Erwan, deGroote, Pascal, Mewton, Nathan, Mansencal, Nicolas, Raphael, Pierre, Ghanem, Nachwan, Seronde, Marie‐France, Chavelas, Christophe, Rosamel, Yann, and Beauvais, Florence

Subjects
HOSPITAL admission & discharge, HEART failure, ACE inhibitors, SYSTOLIC blood pressure, VENTRICULAR ejection fraction, PATIENT discharge instructions
Abstract

Aims: Hospitalization for acute heart failure (HF) is followed by a vulnerable time with increased risk of readmission or death, thus requiring particular attention after discharge. In this study, we examined the impact of intensive, early follow‐up among patients at high readmission risk at discharge after treatment for acute HF. Methods and results: Hospitalized acute HF patients were included with at least one of the following: previous acute HF < 6 months, systolic blood pressure ≤ 110 mmHg, creatininaemia ≥ 180 µmol/L, or B‐type natriuretic peptide ≥ 350 pg/mL or N‐terminal pro B‐type natriuretic peptide ≥ 2200 pg/mL. Patients were randomized to either optimized care and education with serial consultations with HF specialist and dietician during the first 2–3 weeks, or to standard post‐discharge care according to guidelines. The primary endpoint was all‐cause death or first unplanned hospitalization during 6‐month follow‐up. Among 482 randomized patients (median age 77 and median left ventricular ejection fraction 35%), 224 were hospitalized or died. In the intensive group, loop diuretics (46%), beta‐blockers (49%), angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers (39%) and mineralocorticoid receptor antagonists (47%) were titrated. No difference was observed between groups for the primary endpoint (hazard ratio 0.97; 95% confidence interval 0.74–1.26), nor for mortality at 6 or 12 months or unplanned HF rehospitalization. Additionally, no difference between groups according to age, previous HF and left ventricular ejection fraction was found. Conclusions: In high‐risk HF, intensive follow‐up early post‐discharge did not improve outcomes. This vulnerable post‐discharge time requires further studies to clarify useful transitional care services. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Whole Exome Sequencing Reveals a Large Genetic Heterogeneity and Revisits the Causes of Hypertrophic Cardiomyopathy

Author

Nguyen, Karine, Roche, Stéphane, Donal, Erwan, Odent, Sylvie, Eicher, Jean-Christophe, Faivre, Laurence, Millat, Gilles, Salgado, David, Desvignes, Jean-Pierre, Lavoute, Cécile, Haentjens, Julie, Consolino, Émilie, Janin, Alexandre, Cerino, Mathieu, Réant, Patricia, Rooryck, Caroline, Charron, Philippe, Richard, Pascale, Casalta, Anne-Claire, Michel, Nicolas, Magdinier, Frédérique, Béroud, Christophe, Lévy, Nicolas, Habib, Gilbert, Département de génétique médicale [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Department of Experimental Cardiology, Heart Failure Research Center (HFRC)-Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Hospices Civils de Lyon (HCL), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Département de Cardiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Centre de Biologie et de pathologie Est, Département de cardiologie, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Maladies Rares - Génétique et Métabolisme (MRGM), Université Bordeaux Segalen - Bordeaux 2-Hôpital Pellegrin-Service de Génétique Médicale du CHU de Bordeaux, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Unité Fonctionnelle de Cardiogénétique et Myogénétique Moléculaire et Cellulaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA)-Heart Failure Research Center (HFRC), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Roche, Stephane

Subjects
Adult, Male, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, whole exome sequencing, Genetic Heterogeneity, Young Adult, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Exome Sequencing, Humans, Exome, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, amyloidosis, Fabry disease, genetic counseling, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cardiomyopathy, Hypertrophic, Middle Aged, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], dilatation
Abstract

International audience

Published
2019

40. Sex‐ and Age‐Related Differences in the Management and Outcomes of Chronic Heart Failure: an Analysis of Patients from the ESC HFA EORP Heart Failure Long‐Term Registry

Author

Lainscak, Mitja, Milinković, Ivan, Polovina, Marija, Crespo-Leiro, María Generosa, Lund, Lars H., Anker, Stefan, Laroche, Cécile, Ferrari, Roberto, Coats, Andrew J.S., McDonagh, Theresa A., Filippatos, Gerasimos, Maggioni, Aldo P., Piepoli, Massimo Francesco, Rosano, Giuseppe, Ruschitzka, Frank, Simić, Dragan, Ašanin, Milika, Eicher, Jean‐Christophe, Yilmaz, Mehmet Birhan, Seferovic, Petar M., Lainscak, Mitja, Milinković, Ivan, Polovina, Marija, Crespo-Leiro, María Generosa, Lund, Lars H., Anker, Stefan, Laroche, Cécile, Ferrari, Roberto, Coats, Andrew J.S., McDonagh, Theresa A., Filippatos, Gerasimos, Maggioni, Aldo P., Piepoli, Massimo Francesco, Rosano, Giuseppe, Ruschitzka, Frank, Simić, Dragan, Ašanin, Milika, Eicher, Jean‐Christophe, Yilmaz, Mehmet Birhan, and Seferovic, Petar M.

Abstract

[Abstract] Aims. This study aimed to assess age‐ and sex‐related differences in management and 1‐year risk for all‐cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results. Of 16 354 patients included in the European Society of Cardiology Heart Failure Long‐Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline‐directed medical therapy (GDMT) were high (angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, beta‐blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P ≤ 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1‐year follow‐up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all‐cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all‐cause hospitalization (21.9% vs. 27.3%; P < 0.001) and there were no differences in causes of death. All‐cause mortality and all‐cause hospitalization increased with greater age in both sexes. Sex was not an independent predictor of 1‐year all‐cause mortality (restricted to patients with LVEF ≤45%). Mortality risk was significantly lower in patients of younger age, compared to patients aged >75 years. Conclusions. There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all‐cause mortality in patients with LVEF ≤45%.

Published
2019

41. Pulmonary hypertension in chronic heart failure definitions, advances, and unanswered issues

Author

Berthelot, Emmanuelle, Bauer, Fabrice, Eicher, Jean-Christophe, Flecher, Erwan, Gellen, Barnabas, Guihaire, Julien, Guijarro, Damien, Roul, Gerald, Salvat, Muriel, Tribouilloy, Christophe, Zores, Florian, Lamblin, Nicolas, de Groote, Pascal, Damy, Thibaud, Université Paris-Sud - Paris 11 (UP11), Hôpital Bicêtre, Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Polyclinique de Poitiers, CHU Grenoble, Université de Strasbourg (UNISTRA), CHU La Tronche, CHU Amiens-Picardie, Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, Hypertension, Pulmonary, Hemodynamics, Reviews, Heart failure, Review, Heart transplantation, Global Health, Prognosis, Classification, Pathophysiology, Pulmonary hypertension, Treatment, Diagnosis, Prevalence, Humans, [SDV.IB]Life Sciences [q-bio]/Bioengineering
Abstract

International audience; Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post-capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets.

Published
2018

42. Targeted panel sequencing in adult patients with left ventricular non-compaction reveals a large genetic heterogeneity

Author

Richard, P., primary, Ader, F., additional, Roux, M., additional, Donal, Erwan, additional, Eicher, Jean-Christophe, additional, Aoutil, N., additional, Huttin, O., additional, Coisne, D., additional, Jondeau, Guillaume, additional, Damy, Thibaud, additional, Mansencal, N., additional, Casalta, A.C., additional, Michel, N., additional, Haentjens, J., additional, Faivre, L., additional, Lavoute, C., additional, Nguyen, K., additional, Tregouet, D.A., additional, Habib, Gilbert, additional, and Charron, Philippe, additional

Published
2019
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43. Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia

Author

Siméon, S., primary, Le Moing, V., additional, Tubiana, S., additional, Duval, X., additional, Fournier, D., additional, Lavigne, J.-P., additional, Erpelding, M.-L., additional, Gustave, C.-A., additional, Desage, S., additional, Chirouze, C., additional, Vandenesch, F., additional, Tattevin, P., additional, Chirouze, Catherine, additional, Curlier, Elodie, additional, Descottes-Genon, Cécile, additional, Hoen, Bruno, additional, Patry, Isabelle, additional, Vettoretti, Lucie, additional, Chavanet, Pascal, additional, Eicher, Jean-Christophe, additional, Gohier-Treuvelot, Sandrine, additional, Greusard, Marie-Christine, additional, Neuwirth, Catherine, additional, Péchinot, André, additional, Piroth, Lionel, additional, Célard, Marie, additional, Cornu, Catherine, additional, Delahaye, François, additional, Hadid, Malika, additional, Rausch, Pascale, additional, Coma, Audrey, additional, Galtier, Florence, additional, Géraud, Philippe, additional, Jean-Pierre, Hélène, additional, Le Moing, Vincent, additional, Sportouch, Catherine, additional, Reynes, Jacques, additional, Aissa, Nejla, additional, Doco-Lecompte, Thanh, additional, Goehringer, François, additional, Keil, Nathalie, additional, Letranchant, Lorraine, additional, Malela, Hepher, additional, May, Thierry, additional, Selton-Suty, Christine, additional, Bedos, Nathalie, additional, Lavigne, Jean-Philippe, additional, Lechiche, Catherine, additional, Sotto, Albert, additional, Duval, Xavier, additional, Habensus, Emila Ilic, additional, Iung, Bernard, additional, Leport, Catherine, additional, Longuet, Pascale, additional, Ruimy, Raymond, additional, Bellissant, Eric, additional, Donnio, Pierre-Yves, additional, Le Gac, Fabienne, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Thebault, Elise, additional, Alla, François, additional, Braquet, Pierre, additional, Erpelding, Marie-Line, additional, Minary, Laetitia, additional, Tubiana, Sarah, additional, Bès, Michèle, additional, Etienne, Jérôme, additional, Lelekov-Boissard, Taissia, additional, Tristan, Anne, additional, Vandenesch, François, additional, Van Belkum, Alex, additional, Rivadeneira, Fernando, additional, Vanwamel, Willem, additional, Barbas, Sandrine, additional, Delonca, Christine, additional, Sussmuth, Virginie, additional, and Verchère, Anne, additional

Published
2019
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44. Genetic spectrum of hypertrophic cardiomyopathy revisited. Whole Exome Sequencing reveals extreme genetic heterogeneity, new gene mutations in a multicenter series of 200 patients

Author

Nguyen, K., primary, Roche, S., additional, Lavoute, C., additional, Reant, P., additional, Donal, Erwan, additional, Haentjens, J., additional, Consolino, E., additional, Odent, S., additional, Habib, G., additional, Eicher, Jean-Christophe, additional, Faivre, L., additional, Rooryck-Thambo, C., additional, Charron, P., additional, Casalta, A.C., additional, and Michel, N., additional

Published
2019
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45. 1- and 5-year outcomes of heart failure patients with reduced and preserved ejection fraction after acute decompensation according to the final destination after emergency department care

Author

Guignant, P., primary, Raitiere, Olivier, additional, Logeart, Damien, additional, Isnard, Richard, additional, Seronde, Marie-France, additional, De Groote, Pascal, additional, Jondeau, Guillaume, additional, Galinier, Michel, additional, Donal, Erwan, additional, Juilliere, Y., additional, Damy, Thibaud, additional, Jourdain, P., additional, Eicher, Jean-Christophe, additional, Trochu, Jean-Noël, additional, and Bauer, Fabrice, additional

Published
2019
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46. Targeted panel sequencing in adult patients with left ventricular non‐compaction reveals a large genetic heterogeneity

Author

Richard, Pascale, primary, Ader, Flavie, additional, Roux, Maguelonne, additional, Donal, Erwan, additional, Eicher, Jean‐Christophe, additional, Aoutil, Nadia, additional, Huttin, Olivier, additional, Selton‐Suty, Christine, additional, Coisne, Damien, additional, Jondeau, Guillaume, additional, Damy, Thibaud, additional, Mansencal, Nicolas, additional, Casalta, Anne‐Claire, additional, Michel, Nicolas, additional, Haentjens, Julie, additional, Faivre, Laurence, additional, Lavoute, Cecile, additional, Nguyen, Karine, additional, Tregouët, David‐Alexandre, additional, Habib, Gilbert, additional, and Charron, Philippe, additional

Published
2018
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49. Sex- and age-related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long-Term Registry.

Author

Lainščak, Mitja, Milinković, Ivan, Polovina, Marija, Crespo‐Leiro, Marisa G., Lund, Lars H., Anker, Stefan D., Laroche, Cécile, Ferrari, Roberto, Coats, Andrew J.S., McDonagh, Theresa, Filippatos, Gerasimos, Maggioni, Aldo P., Piepoli, Massimo F., Rosano, Giuseppe M.C., Ruschitzka, Frank, Simić, Dragan, Ašanin, Milika, Eicher, Jean‐Christophe, Yilmaz, Mehmet B., and Seferović, Petar M.

Subjects
HEART failure patients, HEART failure, ACE inhibitors, MINERALOCORTICOID receptors, VENTRICULAR ejection fraction, HEART failure treatment, LEFT heart ventricle, RESEARCH, RESEARCH methodology, ARTHRITIS Impact Measurement Scales, ACQUISITION of data, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, HOSPITAL care, RESEARCH funding, STROKE volume (Cardiac output), HEART physiology
Abstract

Aims: This study aimed to assess age- and sex-related differences in management and 1-year risk for all-cause mortality and hospitalization in chronic heart failure (HF) patients.Methods and Results: Of 16 354 patients included in the European Society of Cardiology Heart Failure Long-Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline-directed medical therapy (GDMT) were high (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P ≤ 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1-year follow-up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all-cause mortality were lower in women than in men (7.1% vs. 8.7%; P = 0.015), as were rates of all-cause hospitalization (21.9% vs. 27.3%; P < 0.001) and there were no differences in causes of death. All-cause mortality and all-cause hospitalization increased with greater age in both sexes. Sex was not an independent predictor of 1-year all-cause mortality (restricted to patients with LVEF ≤45%). Mortality risk was significantly lower in patients of younger age, compared to patients aged >75 years.Conclusions: There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all-cause mortality in patients with LVEF ≤45%. [ABSTRACT FROM AUTHOR]

Published
2020
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50. Temporal Trends in Transcatheter Aortic Valve Replacement in France

Author

Auffret, Vincent, primary, Lefevre, Thierry, additional, Van Belle, Eric, additional, Eltchaninoff, Hélène, additional, Iung, Bernard, additional, Koning, René, additional, Motreff, Pascal, additional, Leprince, Pascal, additional, Verhoye, Jean Philippe, additional, Manigold, Thibaut, additional, Souteyrand, Geraud, additional, Boulmier, Dominique, additional, Joly, Patrick, additional, Pinaud, Frédéric, additional, Himbert, Dominique, additional, Collet, Jean Philippe, additional, Rioufol, Gilles, additional, Ghostine, Said, additional, Bar, Olivier, additional, Dibie, Alain, additional, Champagnac, Didier, additional, Leroux, Lionel, additional, Collet, Frédéric, additional, Teiger, Emmanuel, additional, Darremont, Olivier, additional, Folliguet, Thierry, additional, Leclercq, Florence, additional, Lhermusier, Thibault, additional, Olhmann, Patrick, additional, Huret, Bruno, additional, Lorgis, Luc, additional, Drogoul, Laurent, additional, Bertrand, Bernard, additional, Spaulding, Christian, additional, Quilliet, Laurent, additional, Cuisset, Thomas, additional, Delomez, Maxence, additional, Beygui, Farzin, additional, Claudel, Jean-Philippe, additional, Hepp, Alain, additional, Jegou, Arnaud, additional, Gommeaux, Antoine, additional, Mirode, Anfani, additional, Christiaens, Luc, additional, Christophe, Charles, additional, Cassat, Claude, additional, Metz, Damien, additional, Mangin, Lionel, additional, Isaaz, Karl, additional, Jacquemin, Laurent, additional, Guyon, Philippe, additional, Pouillot, Christophe, additional, Makowski, Serge, additional, Bataille, Vincent, additional, Rodés-Cabau, Josep, additional, Gilard, Martine, additional, Le Breton, Hervé, additional, Le Breton, Herve, additional, Laskar, Marc, additional, Chevalier, Bernard, additional, Garot, Philippe, additional, Hovasse, Thomas, additional, Donzeau Gouge, Patrick, additional, Farge, Arnaud, additional, Romano, Mauro, additional, Cormier, Bertrand, additional, Bouvier, Erik, additional, Bauchart, Jean-Jacques, additional, Bodart, Jean-Christophe, additional, Delhaye, Cédric, additional, Houpe, David, additional, Lallemant, Robert, additional, Leroy, Fabrice, additional, Sudre, Arnaud, additional, Juthier, Francis, additional, Koussa, Mohamed, additional, Modine, Thomas, additional, Rousse, Natacha, additional, Auffray, Jean-Luc, additional, Richardson, Marjorie, additional, Berland, Jacques, additional, Godin, Mathieu, additional, Bessou, Jean-Paul, additional, Letocart, Vincent, additional, Roussel, Jean-Christian, additional, Jaafar, Philippe, additional, Combaret, Nicolas, additional, D’Ostrevy, Nicolas, additional, Innorta, Andréa, additional, Clerfond, Guillaume, additional, Vorilhon, Charles, additional, Auffret, Vincent, additional, Bedossa, Marc, additional, Leurent, Guillaume, additional, Anselmi, Amedeo, additional, Harmouche, Majid, additional, Verhoye, Jean-Philippe, additional, Donal, Erwan, additional, Bille, Jacques, additional, Houel, Rémi, additional, Vilette, Bertrand, additional, Abi Khalil, Wissam, additional, Delepine, Stéphane, additional, Fouquet, Olivier, additional, Rouleau, Frédéric, additional, Abtan, Jérémie, additional, Urena, Marina, additional, Alkhoder, Soleiman, additional, Ghodbane, Walid, additional, Arangalage, Dimitri, additional, Brochet, Eric, additional, Goublaire, Coppelia, additional, Barthelemy, Olivier, additional, Choussat, Rémi, additional, Collet, Jean-Philippe, additional, Lebreton, Guillaume, additional, Mastrioanni, Chiro, additional, Isnard, Richard, additional, Dauphin, Raphael, additional, Dubreuil, Olivier, additional, Durand De Gevigney, Guy, additional, Finet, Gérard, additional, Harbaoui, Brahim, additional, Ranc, Sylvain, additional, Farhat, Fadi, additional, Jegaden, Olivier, additional, Obadia, Jean-François, additional, Pozzi, Matteo, additional, Ghostine, Saïd, additional, Brenot, Philippe, additional, Fradi, Sahbi, additional, Azmoun, Alexandre, additional, Deleuze, Philippe, additional, Kloeckner, Martin, additional, Blanchard, Didier, additional, Barbey, Christophe, additional, Chassaing, Stephan, additional, Chatel, Didier, additional, Le Page, Olivier, additional, Tauran, Arnaud, additional, Bruere, Didier, additional, Bodson, Laurent, additional, Meurisse, Yvon, additional, Seemann, Aurélien, additional, Amabile, Nicolas, additional, Caussin, Christophe, additional, Elhaddad, Simon, additional, Drieu, Luc, additional, Ohanessian, Alice, additional, Philippe, François, additional, Veugeois, Aurélie, additional, Debauchez, Matthieu, additional, Zannis, Konstantinos, additional, Czitrom, Daniel, additional, Diakov, Chrystelle, additional, Raoux, François, additional, Lienhart, Yves, additional, Staat, Patrick, additional, Zouaghi, Oualid, additional, Doisy, Vincent, additional, Frieh, Jean Philippe, additional, Wautot, Fabrice, additional, Dementhon, Julie, additional, Garrier, Olivier, additional, Jamal, Fadi, additional, Leroux, Pierre Yves, additional, Casassus, Frédéric, additional, Seguy, Benjamin, additional, Barandon, Laurent, additional, Labrousse, Louis, additional, Peltan, Julien, additional, Cornolle, Claire, additional, Dijos, Marina, additional, Lafitte, Stéphane, additional, Bayet, Gilles, additional, Charmasson, Claude, additional, Vaillant, Alain, additional, Vicat, Jacques, additional, Giacomoni, Marie Paule, additional, Bergoend, Eric, additional, Zerbib, Céline, additional, Louis Leymarie, Jean, additional, Clerc, Philippe, additional, Choukroun, Emmanuel, additional, Elia, Nicolas, additional, Grimaud, Jean-Philippe, additional, Guibaud, Jean-Philippe, additional, Wroblewski, Stéphane, additional, Abergel, Eric, additional, Bogino, Emmanuel, additional, Chauvel, Christophe, additional, Dehant, Patrick, additional, Simon, Marc, additional, Angioi, Michel, additional, Lemoine, Julien, additional, Lemoine, Simon, additional, Popovic, Batric, additional, Maureira, Pablo, additional, Huttin, Olivier, additional, Selton Suty, Christine, additional, Cayla, Guillaume, additional, Delseny, Delphine, additional, Levy, Gilles, additional, Macia, Jean Christophe, additional, Maupas, Eric, additional, Piot, Christophe, additional, Rivalland, François, additional, Robert, Gabriel, additional, Schmutz, Laurent, additional, Targosz, Frédéric, additional, Albat, Bernard, additional, Dubar, Arnaud, additional, Durrleman, Nicolas, additional, Gandet, Thomas, additional, Munos, Emmanuel, additional, Cade, Stéphane, additional, Cransac, Frédéric, additional, Bouisset, Frédéric, additional, Grunenwald, Etienne, additional, Marcheix, Bertrand, additional, Fournier, Pauline, additional, Morel, Olivier, additional, Ohlmann, Patrick, additional, Kindo, Michel, additional, Hoang, Minh Tam, additional, Petit, Hélène, additional, Samet, Hafida, additional, Trinh, Anne, additional, Lecoq, Guillaume, additional, Morelle, Jean François, additional, Richard, Pascal, additional, Derieux, Thierry, additional, Monier, Emmanuel, additional, Joret, Cédric, additional, Bouchot, Olivier, additional, Eicher, Jean Christophe, additional, Meyer, Pierre, additional, Lopez, Stéphane, additional, Tapia, Michel, additional, Teboul, Jacques, additional, Elbeze, Jean-Pierre, additional, Mihoubi, Alain, additional, Vanzetto, Gérald, additional, Wittenberg, Olivier, additional, Bach, Vincent, additional, Martin, Cécile, additional, Sauier, Carole, additional, Casset, Charlotte, additional, Castellant, Philippe, additional, Bezon, Eric, additional, Choplain, Jean-Noel, additional, Kallifa, Ahmed, additional, Nasr, Bahaa, additional, Jobic, Yannick, additional, Lafont, Antoine, additional, Pagny, Jean-Yves, additional, Abi Akar, Ramzi, additional, Fabiani, Jean-Noël, additional, Zegdi, Rachid, additional, Berrebi, Alain, additional, Puscas, Tania, additional, Desveaux, Bernard, additional, Ivanes, Fabrice, additional, Saint Etienne, Christophe, additional, Bourguignon, Thierry, additional, Aupy, Blandine, additional, Perault, Romain, additional, Bonnet, Jean-Louis, additional, Lambert, Marc, additional, Grisoli, Dominique, additional, Jaussaud, Nicolas, additional, Salaun, Erwan, additional, Laghzaoui, Amine, additional, Savoye, Christine, additional, Bignon, Mathieu, additional, Roule, Vincent, additional, Sabatier, Rémy, additional, Ivascau, Calin, additional, Saplacan, Vladimir, additional, Saloux, Eric, additional, Bouchayer, Damien, additional, Tremeau, Guillaume, additional, Diab, Camille, additional, Lapeze, Joel, additional, Pelissier, Franck, additional, Sassard, Thomas, additional, Matz, Catherine, additional, Monsarrat, Nicolas, additional, Carel, Ivan, additional, Sibellas, Franck, additional, Curtil, Alain, additional, Dambrin, Grégoire, additional, Favereau, Xavier, additional, Ghorayeb, Gabriel, additional, Guesnier, Laurent, additional, Khoury, Wassim, additional, Kucharski, Christophe, additional, Pouzet, Bruno, additional, Vaislic, Claude, additional, Cheikh-Khelifa, Riadh, additional, Hilpert, Loïc, additional, Maribas, Philippe, additional, Hannebicque, Gery, additional, Hochart, Philippe, additional, Paris, Marc, additional, Pecheux, Max, additional, Fabre, Olivier, additional, Leborgne, Laurent, additional, Peltier, Marcel, additional, Trojette, Faouzi, additional, Carmi, Doron, additional, Tribouilloy, Christophe, additional, Mergy, Jean, additional, Corbi, Pierre, additional, Raud Raynier, Pascale, additional, Carillo, Sylvain, additional, Hueber, Arnaud, additional, Moulin, Fédéric, additional, Pinelli, Georges, additional, Darodes, Nicole, additional, Pesteil, Francis, additional, Aludaat, Chadi, additional, Torossian, Frédéric, additional, Belle, Loïc, additional, Chavanis, Nicolas, additional, Akret, Chrystelle, additional, Cerisier, Alexis, additional, Favre, Jean Pierre, additional, Fuzellier, Jean François, additional, Pierrard, Romain, additional, Roth, Olivier, additional, Wiedemann, Jean Yves, additional, Bischoff, Nicolas, additional, Gavra, Georghe, additional, Bourrely, Nicolas, additional, Digne, Franck, additional, Najjari, Mohammed, additional, Stratiev, Victor, additional, Bonnet, Nicolas, additional, Mesnildrey, Patrick, additional, Attias, David, additional, Dreyfus, Julien, additional, Karila Cohen, Daniel, additional, Laperche, Thierry, additional, Nahum, Julien, additional, Scheuble, Aliocha, additional, Rambaud, Geoffrey, additional, Brauberger, Eric, additional, Ah Hot, Michel, additional, Allouch, Philippe, additional, Beverelli, Fabrice, additional, Rosencher, Julien, additional, Aubert, Stéphane, additional, Grinda, Jean Michel, additional, and Waldman, Thierry, additional

Published
2017
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