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284 results on '"Eaves, Lindon J."'

2. Genetic association study of childhood aggression across raters, instruments, and age

Author

Ip, Hill F., van der Laan, Camiel M., Krapohl, Eva M. L., Brikell, Isabell, Sánchez-Mora, Cristina, Nolte, Ilja M., St Pourcain, Beate, Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Colodro-Conde, Lucía, Gordon, Scott, Zayats, Tetyana, Aliev, Fazil, Jiang, Chang, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Hammerschlag, Anke R., Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Seppälä, Ilkka, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S., Day, Felix R., Hottenga, Jouke-Jan, Allegrini, Andrea G., Rimfeld, Kaili, Chen, Qi, Lu, Yi, Martin, Joanna, Soler Artigas, María, Rovira, Paula, Bosch, Rosa, Español, Gemma, Ramos Quiroga, Josep Antoni, Neumann, Alexander, Ensink, Judith, Grasby, Katrina, Morosoli, José J., Tong, Xiaoran, Marrington, Shelby, Middeldorp, Christel, Scott, James G., Vinkhuyzen, Anna, Shabalin, Andrey A., Corley, Robin, Evans, Luke M., Sugden, Karen, Alemany, Silvia, Sass, Lærke, Vinding, Rebecca, Ruth, Kate, Tyrrell, Jess, Davies, Gareth E., Ehli, Erik A., Hagenbeek, Fiona A., De Zeeuw, Eveline, Van Beijsterveldt, Toos C.E.M., Larsson, Henrik, Snieder, Harold, Verhulst, Frank C., Amin, Najaf, Whipp, Alyce M., Korhonen, Tellervo, Vuoksimaa, Eero, Rose, Richard J., Uitterlinden, André G., Heath, Andrew C., Madden, Pamela, Haavik, Jan, Harris, Jennifer R., Helgeland, Øyvind, Johansson, Stefan, Knudsen, Gun Peggy S., Njolstad, Pal Rasmus, Lu, Qing, Rodriguez, Alina, Henders, Anjali K., Mamun, Abdullah, Najman, Jackob M., Brown, Sandy, Hopfer, Christian, Krauter, Kenneth, Reynolds, Chandra, Smolen, Andrew, Stallings, Michael, Wadsworth, Sally, Wall, Tamara L., Silberg, Judy L., Miller, Allison, Keltikangas-Järvinen, Liisa, Hakulinen, Christian, Pulkki-Råback, Laura, Havdahl, Alexandra, Magnus, Per, Raitakari, Olli T., Perry, John R. B., Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Bønnelykke, Klaus, Bisgaard, Hans, Sunyer, Jordi, Lehtimäki, Terho, Arseneault, Louise, Standl, Marie, Heinrich, Joachim, Boden, Joseph, Pearson, John, Horwood, L. John, Kennedy, Martin, Poulton, Richie, Eaves, Lindon J., Maes, Hermine H., Hewitt, John, Copeland, William E., Costello, Elizabeth J., Williams, Gail M., Wray, Naomi, Järvelin, Marjo-Riitta, McGue, Matt, Iacono, William, Caspi, Avshalom, Moffitt, Terrie E., Whitehouse, Andrew, Pennell, Craig E., Klump, Kelly L., Burt, S. Alexandra, Dick, Danielle M., Reichborn-Kjennerud, Ted, Martin, Nicholas G., Medland, Sarah E., Vrijkotte, Tanja, Kaprio, Jaakko, Tiemeier, Henning, Davey Smith, George, Hartman, Catharina A., Oldehinkel, Albertine J., Casas, Miquel, Ribasés, Marta, Lichtenstein, Paul, Lundström, Sebastian, Plomin, Robert, Bartels, Meike, Nivard, Michel G., and Boomsma, Dorret I.

Published
2021
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9. Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study

Author

Kremen, William S, O'Brien, Robert C, Panizzon, Matthew S, Prom-Wormley, Elizabeth, Eaves, Lindon J, Eisen, Seth A, Eyler, Lisa T, Hauger, Richard L, Fennema-Notestine, Christine, Fischl, Bruce, Grant, Michael D, Hellhammer, Dirk H, Jak, Amy J, Jacobson, Kristen C, Jernigan, Terry L, Lupien, Sonia J, Lyons, Michael J, Mendoza, Sally P, Neale, Michael C, Seidman, Larry J, Thermenos, Heidi W, Tsuang, Ming T, Dale, Anders M, and Franz, Carol E

Subjects
Biomedical and Clinical Sciences, Health Sciences, Mental Health, Genetics, Prevention, Basic Behavioral and Social Science, Brain Disorders, Behavioral and Social Science, Neurosciences, Aging, 1.2 Psychological and socioeconomic processes, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Aetiology, Mental health, Brain Mapping, Humans, Hydrocortisone, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Phenotype, Prefrontal Cortex, Quantitative Trait, Heritable, Radioimmunoassay, Saliva, Twins, Heritability, Magnetic resonance imaging, Hippocampus, HPA axis structure, Genetic correlation, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

Although glucocorticoid receptors are highly expressed in the prefrontal cortex, the hippocampus remains the predominant focus in the literature examining relationships between cortisol and brain. We examined phenotypic and genetic associations of cortisol levels with the thickness of prefrontal and anterior cingulate cortex regions, and with hippocampal volume in a sample of 388 middle-aged male twins who were 51-59 years old. Small but significant negative phenotypic associations were found between cortisol levels and the thickness of left dorsolateral (superior frontal gyrus, left rostral middle frontal gyrus) and ventrolateral (pars opercularis, pars triangularis, pars orbitalis) prefrontal regions, and right dorsolateral (superior frontal gyrus) and medial orbital frontal cortex. Most of the associations remained significant after adjusting for general cognitive ability, cardiovascular risk factors, and depression. Bivariate genetic analyses suggested that some of the associations were primarily accounted for by shared genetic influences; that is, some of the genes that tend to result in increased cortisol levels also tend to result in reduced prefrontal cortical thickness. Aging has been associated with reduced efficiency of hypothalamic-pituitary-adrenal function, frontal lobe shrinkage, and increases in health problems, but our present data do not allow us to determine the direction of effects. Moreover, the degree or the direction of the observed associations and the extent of their shared genetic underpinnings may well change as these individuals age. Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology.

Published
2010

10. Genetic and Environmental Influences on Cortisol Regulation Across Days and Contexts in Middle-Aged Men

Author

Franz, Carol E., York, Timothy P., Eaves, Lindon J., Mendoza, Sally P., Hauger, Richard L., Hellhammer, Dirk H., Jacobson, Kristen C., Levine, Seymour, Lupien, Sonia J., Lyons, Michael J., Prom-Wormley, Elizabeth, Xian, Hong, and Kremen, William S.

Subjects
Psychology, Public Health/Gesundheitswesen, Health Psychology, Clinical Psychology, Salivary cortisol, Heritability, Genetics, Twins, HPA axis
Abstract

Cortisol is an indicator of hypothalamic–pituitary–adrenal axis responsivity to stress, but few twin studies have examined the heritability of cortisol concentrations in adults across the diurnal cycle and in different contexts. Saliva samples were provided by 783 middle-aged male twins on one laboratory and two home days as part of the Vietnam Era Twin Study of Aging. Significant cortisol heritability estimates were found for laboratory measures only: awakening (.56); 30 min after awakening (.48); 1000 h (.42); mean output across the day (.43); and mean cortisol awakening response (.64). Twin correlations at home were low. In the laboratory, they were unchanged for fraternal twins, but increased for identical twins. Greater measurement error at home did not appear to account for home-laboratory differences. The results suggest that genetic factors influence cortisol responses to specific environmental stressors. Thus, cortisol levels are correlated in identical twins only when they undergo similar experiences.

Published
2010

12. Social and Genetic Influences on Adolescent Religious Attitudes and Practices

Author

Eaves, Lindon J., Hatemi, Peter K., Prom-Womley, Elizabeth C., and Murrelle, Lenn

Abstract

The authors explore the contributions of social and genetic influences to religious attitudes and practices in a population-based sample of 11-18 year olds and their mothers who responded to a Religious Attitudes and Practices Inventory and Religious Rearing Practices Inventory respectively. Contrary to genetic studies examining adult religious behavior, genetic influences were small, accounting for only 10 percent of the variance. Rather, the effects of the social environment were much larger, greater than 50 percent, and a majority of offspring similarity was explained by familial rearing. In light of the divergent finding between adults and adolescents, one supporting a socialization model and the other a genetic model, the importance of integrating genetic and social science methodology for complex social behaviors is discussed. (Contains 8 tables and 1 note.)

Published
2008

27. Genetic Influences on Political Ideologies: Twin Analyses of 19 Measures of Political Ideologies from Five Democracies and Genome-Wide Findings from Three Populations

Author

Hatemi, Peter K., Medland, Sarah E., Klemmensen, Robert, Oskarsson, Sven, Littvay, Levente, Dawes, Christopher T., Verhulst, Brad, McDermott, Rose, Nørgaard, Asbjørn Sonne, Klofstad, Casey A., Christensen, Kaare, Johannesson, Magnus, Magnusson, Patrik K. E., Eaves, Lindon J., and Martin, Nicholas G.

Published
2014
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46. Replication of linkage studies of complex traits: an examination of variation in location estimates

Author

Roberts, Seth B., MacLean, Charles J., Neale, Michael C., Eaves, Lindon J., and Kendler, Kenneth S.

Subjects
Linkage (Genetics) -- Research, Chromosome mapping -- Methods, Medical statistics -- Research, Biomathematics -- Research, Psychiatry -- Genetic aspects, Computer simulation -- Usage, Biological sciences
Abstract

Replication of linkage studies of complex traits is discussed. The distance at which to reject the hypothesis that two location estimates in a genomic region represent the same gene is addressed. For conditions studied the standard error of a location estimate is a function of the magnitude of the expected LOD score.

Published
1999

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