1,590 results on '"E., Navarro"'
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2. Lifetimes of excited states in P-, As- and Sb-
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Karls, J., Björkhage, M., Blom, M., Gibson, N. D., Lundgren, O. Hemdal, Ji, M., Kristiansson, M. K., Leimbach, D., Navarrete, J. E. Navarro, Reinhed, P., Ringvall-Moberg, A., Rosen, S., Schmidt, H. T., Simonsson, A., and Hanstorp, D.
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Physics - Atomic Physics - Abstract
Radiative lifetimes of three elements of the nitrogen group have been experimentally investigated at the Double ElectroStatic Ion Ring Experiment (DESIREE) facility at Stockholm University. The experiments were performed through selective laser photodetachment of excited states of P$^-$, As$^-$ and Sb$^-$ ions stored in a cryogenic storage ring. The experimental results were compared with theoretically predicted lifetimes, yielding a mixture of very good agreements in some cases and large discrepancies in others. These results are part of our efforts to map out the lifetimes of all excited states in negative ions. This data can be used to benchmark atomic theories, in particularly with respect to the degree of electron correlation that is incorporated in various theoretical models.
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- 2024
3. Precision measurements on Si-
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Karls, J., Cederquist, H., Gibson, N. D., Grumer, J., Ji, M., Kardasch, I., Leimbach, D., Martini, P., Navarrete, J. E. Navarro, Poulose, R., Rosen, S., Schmidt, H. T., Simonsson, A., Zettergren, H., and Hanstorp, D.
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Physics - Atomic Physics - Abstract
High-precision measurements of the electron affinities (EA) of the three stable isotopes of silicon, $^{28}$Si, $^{29}$Si and $^{30}$Si, have been performed at the cryogenic electrostatic ion-beam storage ring DESIREE. The quantum states of the ions were manipulated using laser depletion, and the ions were photodetached by laser photodetachment threshold spectroscopy. These EA values are the first reported for $^{29}$Si$^-$ and $^{30}$Si$^-$ and provide a reduced uncertainty for $^{28}$Si$^-$. The resulting EAs are $EA(^{28}$Si$) = 1.38952201(17)$ eV, $EA(^{29}$Si$) = 1.38952172(12)$ eV and $EA(^{29}$Si$) = 1.38952078(12)$ eV, with the corresponding isotope shifts $IS(^{29-28}$Si$) = 0.29(16)$ micro eV and $IS(^{30-28}$Si$) = 1.23(16) $ micro eV. In addition to these measurements, the resolution and signal-to-background level was sufficient to reveal the hyperfine structure splitting in the $^{29}$Si$^-$ isotope, which we report to be $1.8(4) micro eV.
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- 2024
4. Lifetimes of excited states in Rh-
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Karls, J., Grumer, J., Schiffmann, S., Gibson, N. D., Ji, M., Kristiansson, M. K., Leimbach, D., Navarrete, J. E. Navarro, Rodrıguez, Y. Pena, Ponce, R., Ringvall-Moberg, A., Schmidt, H. T., Spielman, S. E., Walter, C. W., Brage, T., and Hanstorp, D.
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Physics - Atomic Physics - Abstract
The radiative decay of excited states of the negative ion of rhodium, Rh$^-$, has been investigated experimentally and theoretically. The experiments were conducted at the Double ElectroStatic Ion Ring Experiment (DESIREE) facility at Stockholm University using selective photodetachment from a stored ion beam to monitor the time evolution of the excited state populations. The lifetimes of the Rh$^-$ $^3F_{3}$ and $^3F_{2}$ fine structure levels were measured to be 3.2(6)~s and 21(4)~s, respectively. An additional, previously unreported, higher-lying bound state of mixed $^1D_2+^3P_2+(4d^95s)^1D_2+^3F_2$ composition was observed and found to have a lifetime of 10.9(8)s. The binding energy of this state was determined to be in the interval $0.1584(2) $ eV $ < E_b < 0.2669(2)$ eV, using laser photodetachment threshold (LPT) spectroscopy. An autodetaching state with a lifetime of 480(10) microseconds was also observed. Theoretical calculations of the excited-state compositions, energies, and magnetic-dipole transition lifetimes were performed using the multiconfiguration Dirac-Hartree-Fock and relativistic configuration interaction methods. The calculated lifetimes of the $^3F_{3}$ and $^3F_{2}$ fine structure levels are in excellent agreement with the measured values. The present study should provide valuable insights into electron correlation effects in negative ions and forbidden radiative transitions.
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- 2024
5. Reply to: The stabilization of cyanonaphthalene by fast radiative cooling
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Mark H. Stockett, James N. Bull, Henrik Cederquist, Suvasthika Indrajith, MingChao Ji, José E. Navarro Navarrete, Henning T. Schmidt, Henning Zettergren, and Boxing Zhu
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Science - Published
- 2024
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6. Measurement of energy resolution with the NEXT-White silicon photomultipliers
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The NEXT collaboration, T. Contreras, B. Palmeiro, H. Almazán, A. Para, G. Martínez-Lema, R. Guenette, C. Adams, V. Álvarez, B. Aparicio, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodríguez, F. I. G. M. Borges, A. Brodolin, N. Byrnes, S. Cárcel, A. Castillo, S. Cebrián, E. Church, L. Cid, C. A. N. Conde, F. P. Cossío, E. Dey, G. Díaz, T. Dickel, C. Echevarria, M. Elorza, J. Escada, R. Esteve, R. Felkai, L. M. P. Fernandes, P. Ferrario, A. L. Ferreira, F. W. Foss, Z. Freixa, J. García-Barrena, J. J. Gómez-Cadenas, R. González, J. W. R. Grocott, J. Hauptman, C. A. O. Henriques, J. A. Hernando Morata, P. Herrero-Gómez, V. Herrero, C. Hervés Carrete, Y. Ifergan, B. J. P. Jones, F. Kellerer, L. Larizgoitia, A. Larumbe, P. Lebrun, F. Lopez, N. López-March, R. Madigan, R. D. P. Mano, A. P. Marques, J. Martín-Albo, M. Martínez-Vara, R. L. Miller, K. Mistry, J. Molina-Canteras, F. Monrabal, C. M. B. Monteiro, F. J. Mora, K. E. Navarro, P. Novella, A. Nuñez, D. R. Nygren, E. Oblak, J. Palacio, I. Parmaksiz, A. Pazos, J. Pelegrin, M. Pérez Maneiro, M. Querol, A. B. Redwine, J. Renner, I. Rivilla, C. Rogero, L. Rogers, B. Romeo, C. Romo-Luque, F. P. Santos, J. M. F. dos Santos, M. Seemann, I. Shomroni, P. A. O. C. Silva, A. Simón, S. R. Soleti, M. Sorel, J. Soto-Oton, J. M. R. Teixeira, S. Teruel-Pardo, J. F. Toledo, C. Tonnelé, J. Torrent, A. Trettin, A. Usón, P. R. G. Valle, J. F. C. A. Veloso, J. Waiton, and A. Yubero-Navarro
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Dark Matter and Double Beta Decay (experiments) ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract The NEXT-White detector, a high-pressure gaseous xenon time projection chamber, demonstrated the excellence of this technology for future neutrinoless double beta decay searches using photomultiplier tubes (PMTs) to measure energy and silicon photomultipliers (SiPMs) to extract topology information. This analysis uses 83m Kr data from the NEXT-White detector to measure and understand the energy resolution that can be obtained with the SiPMs, rather than with PMTs. The energy resolution obtained of (10.9 ± 0.6)%, full-width half-maximum, is slightly larger than predicted based on the photon statistics resulting from very low light detection coverage of the SiPM plane in the NEXT-White detector. The difference in the predicted and measured resolution is attributed to poor corrections, which are expected to be improved with larger statistics. Furthermore, the noise of the SiPMs is shown to not be a dominant factor in the energy resolution and may be negligible when noise subtraction is applied appropriately, for high-energy events or larger SiPM coverage detectors. These results, which are extrapolated to estimate the response of large coverage SiPM planes, are promising for the development of future, SiPM-only, readout planes that can offer imaging and achieve similar energy resolution to that previously demonstrated with PMTs.
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- 2024
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7. Long-term treatment for unspecified anxiety disorders with cannabidiol (CBD): A retrospective case series from real-world evidence (RWE) in Colombia
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Juan F. Galvez-Florez, Hernan F. Guillen-Burgos, Camilo A. Flórez-Puentes, Cristian E. Navarro, and Guillermo Moreno-Sanz
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Medicine - Abstract
Introduction: Preclinical and clinical evidence has elucidated that cannabis based medical formulations (CBMFs) may display anxiolytic, anti-depressive, and neuro-protective properties. CBMFs are often considered as novel therapeutic anxiolytic agents that can be prescribed as pharmacotherapy for symptomatic domains in anxiety disorders. Our aim was to explore effectiveness and tolerability of enriched cannabidiol (CBD) oil extract formulations in adults with anxiety symptoms in an outpatient mental health program in Colombia during the COIVD – 19 pandemic. Methods: We conducted an observational, retrospective, real world evidence (RWE) case-series at Zerenia Clinic in Bogotá, Colombia between June 2021 and December 2022. Our convenience sample consisted of people searching for CBMFs for the treatment of anxiety symptoms. A cohort of 24 adults was prescribed with enriched CBD in the form of non-sterile oral liquids suspended in sesame seed oil extracts unspecified anxiety disorder (UAD) and followed throughout the first year of treatment. Primary outcome measures established were the anxiety subscale in the hospital anxiety and depression scale (HADS – A), and the clinical global impression scale with regards to severity (CGI – S) at baseline, 6-month, and 12-month during follow-up. Secondary outcome measures established were HADS depression subscale (HADS – D) and the Epworth Sleepiness Scale (ESS) respectively. Results: After 6 months of treatment with sublingually administered enriched CBD oil extracts in a median dosage of 100mg, more than half (54.17%) of the sample continued to report significant anxiety symptoms. After 12 months, only 37.50% persisted with significant anxiety symptoms with a median dose of 120mgs of enriched CBD oil extracts. Similar subjective improvements were reported with regards to sleep disturbances (SDs) as a secondary outcome. At baseline, less than half (46,83%) of the sample reported significant daytime sleepiness. After 6-months of enriched CBD oil extract treatment, less than one third(29,17%) continued to report SDs. At end point, a high proportion of the sample (87.50%) were considered to have normal daytime sleepiness. No significant adverse–drug reactions or deaths were reported during the 12-month follow-up. Conclusions: Further research should determine the long-term efficacy, safety and appropriate dosages of enriched CBD oil extracts in treating specific anxiety disorders rather than broad and unspecified anxiety symptoms. The state of the art of MCBFs for anxiety disorders should be warranted and solidified through randomized controlled trials. The next stage for cannabis research should be focused in performing head-to-head trials comparing enriched CBD extracts or capsules versus first-line treatments proven to be effective in anxiety disorders.
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- 2024
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8. Treatment of Neuropsychiatric Symptoms in Alzheimer’s Disease with a Cannabis-Based Magistral Formulation: An Open-Label Prospective Cohort Study
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Cristian E. Navarro and Juan C. Pérez
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alzheimer disease ,behavioral symptoms ,cannabidiol ,cannabis ,dementia ,Medicine - Abstract
Introduction: Neuropsychiatric symptoms (NPS) may be disruptive and problematic for patients with Alzheimer’s disease (AD) and for their caregivers. Cannabidiol (CBD) may be a safer alternative. The objective was to evaluate whether CBD-rich oil was effective, and safe in adults with NPS secondary to AD. Methods: An open-label, prospective cohort, single-center study in patients with AD onset after the age of 65 with untreated NPS. A CBD-rich oil was administrated 0.1 mL sublingually every 8–12 h, up-titrated weekly. The primary outcome was to establish a reduction in the NPI-Q severity score of >30% at 12 weeks compared with the baseline. A p value of 30% was 94.9%, while a reduction of >50% was achieved by 54.2%. The improvement was maintained for up to 24 months. Conclusion: This study shows that CBD-rich oil is an effective and safe therapy for treating NPS in AD patients, while also reducing the caregivers’ distress.
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- 2024
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9. Demonstration of event position reconstruction based on diffusion in the NEXT-white detector
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J. Haefner, K. E. Navarro, R. Guenette, B. J. P. Jones, A. Tripathi, C. Adams, H. Almazán, V. Álvarez, B. Aparicio, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodríguez, F. I. G. M. Borges, A. Brodolin, N. Byrnes, S. Cárcel, J. V. Carrión, S. Cebrián, E. Church, L. Cid, C. A. N. Conde, T. Contreras, F. P. Cossío, E. Dey, G. Díaz, T. Dickel, M. Elorza, J. Escada, R. Esteve, R. Felkai, L. M. P. Fernandes, P. Ferrario, A. L. Ferreira, F. W. Foss, E. D. C. Freitas, Z. Freixa, J. Generowicz, A. Goldschmidt, J. J. Gómez-Cadenas, R. González, J. Grocott, K. Hafidi, J. Hauptman, C. A. O. Henriques, J. A. Hernando Morata, P. Herrero-Gómez, V. Herrero, C. Hervés Carrete, Y. Ifergan, L. Labarga, L. Larizgoitia, A. Larumbe, P. Lebrun, F. Lopez, N. López-March, R. Madigan, R. D. P. Mano, A. P. Marques, J. Martín-Albo, G. Martínez-Lema, M. Martínez-Vara, Z. E. Meziani, R. L. Miller, K. Mistry, J. Molina-Canteras, F. Monrabal, C. M. B. Monteiro, F. J. Mora, J. Muñoz Vidal, P. Novella, A. Nuñez, D. R. Nygren, E. Oblak, J. Palacio, B. Palmeiro, A. Para, I. Parmaksiz, J. Pelegrin, M. Pérez Maneiro, M. Querol, A. B. Redwine, J. Renner, I. Rivilla, J. Rodríguez, C. Rogero, L. Rogers, B. Romeo, C. Romo-Luque, F. P. Santos, J. M. F. dos Santos, I. Shomroni, A. Simón, S. R. Soleti, M. Sorel, J. Soto-Oton, J. M. R. Teixeira, J. F. Toledo, J. Torrent, A. Trettin, A. Usón, J. F. C. A. Veloso, J. Waiton, and J. T. White
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Noble element time projection chambers are a leading technology for rare event detection in physics, such as for dark matter and neutrinoless double beta decay searches. Time projection chambers typically assign event position in the drift direction using the relative timing of prompt scintillation and delayed charge collection signals, allowing for reconstruction of an absolute position in the drift direction. In this paper, alternate methods for assigning event drift distance via quantification of electron diffusion in a pure high pressure xenon gas time projection chamber are explored. Data from the NEXT-White detector demonstrate the ability to achieve good position assignment accuracy for both high- and low-energy events. Using point-like energy deposits from $$^{83\textrm{m}}$$ 83 m Kr calibration electron captures ( $$E\sim 45$$ E ∼ 45 keV), the position of origin of low-energy events is determined to 2 cm precision with bias $$< 1~$$ < 1 mm. A convolutional neural network approach is then used to quantify diffusion for longer tracks ( $$E\ge ~1.5$$ E ≥ 1.5 MeV), from radiogenic electrons, yielding a precision of 3 cm on the event barycenter. The precision achieved with these methods indicates the feasibility energy calibrations of better than 1% FWHM at Q $$_{\beta \beta }$$ β β in pure xenon, as well as the potential for event fiducialization in large future detectors using an alternate method that does not rely on primary scintillation.
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- 2024
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10. Resilience of small PAHs in interstellar clouds: Efficient stabilization of cyanonaphthalene by fast radiative cooling
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Stockett, Mark H., Bull, James N., Cederquist, Henrik, Indrajith, Suvasthika, Ji, MingChao, Navarrete, José E. Navarro, Schmidt, Henning T., Zettergren, Henning, and Zhu, Boxing
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Astrophysics - Astrophysics of Galaxies ,Physics - Chemical Physics - Abstract
After decades of speculation and searching, astronomers have recently identified specific Polycyclic Aromatic Hydrocarbons (PAHs) in space. Remarkably, the observed abundance of cyanonaphthalene (CNN, C10H7CN) in the Taurus Molecular Cloud (TMC-1) is six orders of magnitude higher than expected from astrophysical modeling. Here, we report absolute unimolecular dissociation and radiative cooling rate coefficients of the 1-CNN isomer in its cationic form. These results are based on measurements of the time-dependent neutral product emission rate and Kinetic Energy Release distributions produced from an ensemble of internally excited 1-CNN + studied in an environment similar to that in interstellar clouds. We find that Recurrent Fluorescence - radiative relaxation via thermally populated electronic excited states - efficiently stabilizes 1-CNN+ , owing to a large enhancement of the electronic transition probability by vibronic coupling. Our results help explain the anomalous abundance of CNN in TMC-1 and challenge the widely accepted picture of rapid destruction of small PAHs in space.
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- 2022
11. Fluorometric study of molecular association of pectin and algin with ferulic and p-coumaric acids: Evaluation of association capacity of dietary fibers towards antioxidants
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Alex J. Salazar-Medina, Motomichi Inoue, Rosa E. Navarro, and Gustavo A. González-Aguilar
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Dietary fiber ,Antioxidant ,Molecular association ,Polymer complex ,Fluorescence titration ,Chemistry ,QD1-999 - Abstract
Antioxidants undergo molecular association with dietary fibers in plant foods, and the actual nutritional functions depend on the conditions of association. As an approach to quantitative interpretation of the association effects, the present study proposes a method to evaluate association capacity, based on fluorometric titration of ferulic and p-coumaric acids with pectin and algin. The titration curve is formulated on the model that active sites on a fiber chain consist of segments each capable of binding to a single antioxidant molecule. The average segment sizes NS determined from observed curves range from 5 to 12 monomer units, and the mean association constant KA from 5 × 104 to 18 × 104 M−1 per segment, depending on fiber–antioxidant combinations. These parameters suggest that, although individual monomer units have weak binding forces, each segment involves multiple binding sites so that accumulating forces lead to the high thermodynamic stability of the molecular associates; the association capacity is presented by the half association concentration of antioxidant CG1/2 = 2Cm/NS – 2/KA at a monomer-based fiber concentration Cm. The extended application of the method to selected fiber–nutrient combinations would help to describe the association at molecular levels and to design better nutritional agents.
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- 2024
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12. Kalanchoe tomentosa: Phytochemical Profiling, and Evaluation of Its Biological Activities In Vitro, In Vivo, and In Silico
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Jorge L. Mejía-Méndez, Gildardo Sánchez-Ante, Yulianna Minutti-Calva, Karen Schürenkämper-Carrillo, Diego E. Navarro-López, Ricardo E. Buendía-Corona, Ma. del Carmen Ángeles González-Chávez, Angélica Lizeth Sánchez-López, J. Daniel Lozada-Ramírez, Eugenio Sánchez-Arreola, and Edgar R. López-Mena
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Crassulaceae ,genus Kalanchoe ,Kalanchoe tomentosa ,biological properties ,phytochemistry ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
In this work, the leaves of K. tomentosa were macerated with hexane, chloroform, and methanol, respectively. The phytochemical profiles of hexane and chloroform extracts were unveiled using GC/MS, whereas the chemical composition of the methanol extract was analyzed using UPLC/MS/MS. The antibacterial activity of extracts was determined against gram-positive and gram-negative strains through the minimal inhibitory concentration assay, and in silico studies were implemented to analyze the interaction of phytoconstituents with bacterial peptides. The antioxidant property of extracts was assessed by evaluating their capacity to scavenge DPPH, ABTS, and H2O2 radicals. The toxicity of the extracts was recorded against Artemia salina nauplii and Caenorhabditis elegans nematodes. Results demonstrate that the hexane and chloroform extracts contain phytosterols, triterpenes, and fatty acids, whereas the methanol extract possesses glycosidic derivatives of quercetin and kaempferol together with sesquiterpene lactones. The antibacterial performance of extracts against the cultured strains was appraised as weak due to their MIC90 values (>500 μg/mL). As antioxidants, treatment with extracts executed high and moderate antioxidant activities within the range of 50–300 μg/mL. Extracts did not decrease the viability of A. salina, but they exerted a high toxic effect against C. elegans during exposure to treatment. Through in silico modeling, it was recorded that the flavonoids contained in the methanol extract can hamper the interaction of the NAM/NAG peptide, which is of great interest since it determines the formation of the peptide wall of gram-positive bacteria. This study reports for the first time the biological activities and phytochemical content of extracts from K. tomentosa and proposes a possible antibacterial mechanism of glycosidic derivatives of flavonoids against gram-positive bacteria.
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- 2024
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13. Gd(III) and Yb(III) Complexes Derived from a New Water-Soluble Dioxopolyazacyclohexane Macrocycle
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Rosa E. Navarro, Alan Coronado, Motomichi Inoue, Ángel U. Orozco Valencia, Yedith Soberanes, and Alex J. Salazar-Medina
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Chemistry ,QD1-999 - Published
- 2023
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14. Green Synthesis of Silver Nanoparticles with Extracts from Kalanchoe fedtschenkoi: Characterization and Bioactivities
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Jorge L. Mejía-Méndez, Gildardo Sánchez-Ante, Mónica Cerro-López, Yulianna Minutti-Calva, Diego E. Navarro-López, J. Daniel Lozada-Ramírez, Horacio Bach, Edgar R. López-Mena, and Eugenio Sánchez-Arreola
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nanotechnology ,green synthesis ,Kalanchoe fedtschenkoi ,silver nanoparticles ,Microbiology ,QR1-502 - Abstract
In this work, the hexane, chloroform, and methanol extracts from Kalanchoe fedtschenkoi were utilized to green-synthesize silver nanoparticles (Kf1-, Kf2-, and Kf3-AgNPs). The Kf1-, Kf2-, and Kf3-AgNPs were characterized by spectroscopy and microscopy techniques. The antibacterial activity of AgNPs was studied against bacteria strains, utilizing the microdilution assay. The DPPH and H2O2 assays were considered to assess the antioxidant activity of AgNPs. The results revealed that Kf1-, Kf2-, and Kf3-AgNPs exhibit an average diameter of 39.9, 111, and 42 nm, respectively. The calculated ζ-potential of Kf1-, Kf2-, and Kf3-AgNPs were −20.5, −10.6, and −7.9 mV, respectively. The UV-vis analysis of the three samples demonstrated characteristic absorption bands within the range of 350–450 nm, which confirmed the formation of AgNPs. The FTIR analysis of AgNPs exhibited a series of bands from 3500 to 750 cm−1, related to the presence of extracts on their surfaces. SEM observations unveiled that Kf1- and Kf2-AgNPs adopted structural arrangements related to nano-popcorns and nanoflowers, whereas Kf3-AgNPs were spherical in shape. It was determined that treatment with Kf1-, Kf2-, and Kf3-AgNPs was demonstrated to inhibit the growth of E. coli, S. aureus, and P. aeruginosa in a dose-dependent manner (50–300 μg/mL). Within the same range, treatment with Kf1-, Kf2-, and Kf3-AgNPs decreased the generation of DPPH (IC50 57.02–2.09 μg/mL) and H2O2 (IC50 3.15–3.45 μg/mL) radicals. This study highlights the importance of using inorganic nanomaterials to improve the biological performance of plant extracts as an efficient nanotechnological approach.
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- 2024
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15. Two predicted α-helices within the prion-like domain of TIAR-1 play a crucial role in its association with stress granules in Caenorhabditis elegans
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D. A. Fuentes-Jiménez, L. S. Salinas, E. Morales-Oliva, V. A. Ramírez-Ramírez, M. Arciniega, and R. E. Navarro
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stress granules ,TIA1 ,TIAR1 ,TIAR-1 ,stress ,apoptosis ,Biology (General) ,QH301-705.5 - Abstract
Stress granules (SGs) are sites for mRNA storage, protection, and translation repression. TIA1 and TIAR1 are two RNA-binding proteins that are key players in SGs formation in mammals. TIA1/TIAR have a prion-like domain (PrD) in their C-terminal that promotes liquid-phase separation. Lack of any TIA1/TIAR has severe consequences in mice. However, it is not clear whether the failure to form proper SGs is the cause of any of these problems. We disrupted two predicted α-helices within the prion-like domain of the Caenohabditis elegans TIA1/TIAR homolog, TIAR-1, to test whether its association with SGs is important for the nematode. We found that tiar-1 PrD mutant animals continued to form TIAR-1 condensates under stress in the C. elegans gonad. Nonetheless, TIAR-1 condensates appeared fragile and disassembled quickly after stress. Apparently, the SGs continued to associate regularly as observed with CGH-1, an SG marker. Like tiar-1-knockout nematodes, tiar-1 PrD mutant animals exhibited fertility problems and a shorter lifespan. Notwithstanding this, tiar-1 PrD mutant nematodes were no sensitive to stress. Our data demonstrate that the predicted prion-like domain of TIAR-1 is important for its association with stress granules. Moreover, this domain may also play a significant role in various TIAR-1 functions unrelated to stress, such as fertility, embryogenesis and lifespan.
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- 2023
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16. Maternal transmission of bacterial microbiota during embryonic development in a viviparous lizard
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Nina Montoya-Ciriaco, Stephanie Hereira-Pacheco, Arturo Estrada-Torres, Luc Dendooven, Fausto R. Méndez de la Cruz, Elizabeth Selene Gómez-Acata, Aníbal H. Díaz de la Vega-Pérez, and Yendi E. Navarro-Noya
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early life microbiome ,Is microbiome inherited from the mother? ,maternal effects ,maternal microbiome ,microbial transmission ,reptile microbiome ,Microbiology ,QR1-502 - Abstract
ABSTRACT The maternal transmission of microbiota during embryonic development of vertebrates is still poorly understood. Here, we used high-throughput sequencing of the 16S rRNA bacterial genes to determine the bacterial communities in the gastrointestinal tract and amniotic environment, i.e., the amniotic fluid, amniotic membrane and extraembryonic yolk, of embryos at the last stage of development of the viviparous lizard Sceloporus grammicus Wiegmann, 1828. We compared these communities to those found in the maternal intestine, mouth, cloaca, and the aseptic ventral skin as a control of the aseptic technique. Our results showed that bacterial 16S rRNA genes were present in the embryos of S. grammicus. Their diversity was lower and more similar in composition between individuals than those found in the maternal tissues. This suggests that a strong control exists on the transmission of bacteria from the mother to the embryos. We found 78% of the embryonic amplicon sequence variants (ASVs) in the maternal bacterial microbiota, suggesting that the transmission of bacteria from the mother to the embryos is a continuous process and some bacteria may have been transferred during early embryonic stages. The embryonic bacteria were found to overlap mostly with those found in the mouth and aseptic ventral skin of the mother, although it is difficult to conclude that the shared ASVs originated from these maternal tissues. Our study provides evidence of microbiota vertical transfer during embryonic development in the animal kingdom. It also highlights that this maternal transmission could be included in the maternal effects that impact the offspring. IMPORTANCE We investigated the presence and diversity of bacteria in the embryos of the viviparous lizard Sceloporus grammicus and their amniotic environment. We compared this diversity to that found in the maternal intestine, mouth, and cloaca. We detected bacterial DNA in the embryos, albeit with a lower bacterial species diversity than found in maternal tissues. Most of the bacterial species detected in the embryos were also found in the mother, although not all of them. Interestingly, we detected a high similarity in the composition of bacterial species among embryos from different mothers. These findings suggest that there may be a mechanism controlling the transmission of bacteria from the mother to the embryo. Our results highlight the possibility that the interaction between maternal bacteria and the embryo may affect the development of the lizards.
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- 2023
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17. Unraveling the Complex Interactions: Machine Learning Approaches to Predict Bacterial Survival against ZnO and Lanthanum-Doped ZnO Nanoparticles
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Diego E. Navarro-López, Yocanxóchitl Perfecto-Avalos, Araceli Zavala, Marco A. de Luna, Araceli Sanchez-Martinez, Oscar Ceballos-Sanchez, Naveen Tiwari, Edgar R. López-Mena, and Gildardo Sanchez-Ante
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antibacterial ,nanoparticles ,lanthanum ,machine learning ,ZnO ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The rise in antibiotic-resistant bacteria is a global health challenge. Due to their unique properties, metal oxide nanoparticles show promise in addressing this issue. However, optimizing these properties requires a deep understanding of complex interactions. This study incorporated data-driven machine learning to predict bacterial survival against lanthanum-doped ZnO nanoparticles. The effect of incorporation of lanthanum ions on ZnO was analyzed. Even with high lanthanum concentration, no significant variations in structural, morphological, and optical properties were observed. The antibacterial activity of La-doped ZnO nanoparticles against Gram-positive and Gram-negative bacteria was qualitatively and quantitatively evaluated. Nanoparticles induce 60%, 95%, and 55% bacterial death against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, respectively. Algorithms such as Multilayer Perceptron, K-Nearest Neighbors, Gradient Boosting, and Extremely Random Trees were used to predict the bacterial survival percentage. Extremely Random Trees performed the best among these models with 95.08% accuracy. A feature relevance analysis extracted the most significant attributes to predict the bacterial survival percentage. Lanthanum content and particle size were irrelevant, despite what can be assumed. This approach offers a promising avenue for developing effective and tailored strategies to reduce the time and cost of developing antimicrobial nanoparticles.
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- 2024
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18. Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology
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Jorge L. Mejía-Méndez, Diego E. Navarro-López, Araceli Sanchez-Martinez, Oscar Ceballos-Sanchez, Luis Eduardo Garcia-Amezquita, Naveen Tiwari, Karla Juarez-Moreno, Gildardo Sanchez-Ante, and Edgar R. López-Mena
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lanthanide elements ,antioxidant activity ,in vivo toxicity ,machine learning modeling ,sonochemical synthesis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties of ZnO-NPs was analyzed. The cytotoxicity and the reactive oxygen species (ROS) generation capacity of ZnO-NPs were evaluated against breast (MCF7) and colon (HT29) cancer cell lines. Their antioxidant activity was analyzed using a DPPH assay, and their toxicity towards Artemia salina nauplii was also evaluated. The results revealed that treatment with NPs resulted in the death of 10.559–42.546% and 18.230–38.643% of MCF7 and HT29 cells, respectively. This effect was attributed to the ability of NPs to downregulate ROS formation within the two cell lines in a dose-dependent manner. In the DPPH assay, treatment with (La, Sm)-doped ZnO-NPs inhibited the generation of free radicals at IC50 values ranging from 3.898 to 126.948 μg/mL. Against A. salina nauplii, the synthesized NPs did not cause death nor induce morphological changes at the tested concentrations. A series of machine learning (ML) models were used to predict the biological performance of (La, Sm)-doped ZnO-NPs. Among the designed ML models, the gradient boosting model resulted in the greatest mean absolute error (MAE) (MAE 9.027, R2 = 0.86). The data generated in this work provide innovative insights into the influence of La and Sm on the structural arrangement and chemical features of ZnO-NPs, together with their cytotoxicity, antioxidant activity, and in vivo toxicity.
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- 2024
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19. Los mosaicos de vegetación y roca maximizan los servicios hídricos en las zonas altas de montaña del centro de la Argentina
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Ana M. Cingolani, María Poca, Juan I. Whitworth-Hulse, Melisa A. Giorgis, María V. Vaieretti, M. Lucrecia Herrero, Silvia E. Navarro-Ramos, and Daniel Renison
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agua ,arroyos ,estación seca ,recesión del caudal ,rendimiento hídrico ,servicios ecosistémicos ,Environmental sciences ,GE1-350 ,Ecology ,QH540-549.5 - Abstract
En sistemas con lluvias estacionales, el rendimiento hídrico (caudal de salida del curso de agua relativo al área de la cuenca) en la estación seca depende de las lluvias previas y de la infiltración y la evapotranspiración, procesos que, a su vez, están afectados por las características del paisaje. Nuestro objetivo fue evaluar el efecto de distintas variables de paisaje sobre el rendimiento hídrico y la tasa de recesión (tasa a la que disminuye el caudal) durante la estación seca, en cuencas de alta montaña del centro de la Argentina. Seleccionamos 33 cuencas de 9-61 ha, y durante el final de la estación seca de 2017 medimos semanalmente el caudal en sus puntos de cierre durante siete semanas consecutivas. Para cada cuenca calculamos el rendimiento hídrico (mm/mes) promedio y un índice de recesión (adimensional) como la diferencia normalizada del rendimiento entre las últimas y las primeras fechas. Los paisajes extensamente ocupados por un mosaico de pajonal y roca, con pendiente y rugosidad intermedias, tuvieron los rendimientos hídricos máximos (>5 mm/mes). Por lo contrario, el rendimiento hídrico fue más bajo tanto en los paisajes suaves y cubiertos por vegetación, como en los muy ásperos (muy rugosos, escarpados y rocosos). Por su parte, la recesión fue lenta en los paisajes más ásperos y muy abrupta en los paisajes más suaves. Posiblemente, en los paisajes suaves y vegetados se pierde mucha agua por evapotranspiración, mientras que en los paisajes muy ásperos se pierde mucha agua por escorrentía después de las lluvias. Los paisajes con aspereza intermedia y un mosaico de vegetación y roca serían los que optimizan el almacenamiento, minimizando las pérdidas por evapotranspiración. Por lo tanto, para sostener el rendimiento hídrico es prioritario conservar este tipo de paisajes, evitando la erosión del suelo que genera un aumento de áreas rocosas.
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- 2023
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20. Changes in the bacterial and microeukaryotic communities in the bioreactor upon increasing heavy metal concentrations
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Claudia E. Aceves-Suriano, Nina Montoya-Ciriaco, Mario Hernández-Guzmán, Gabriel R. Hernández-Martínez, Yendi E. Navarro-Noya, Frédéric Thalasso, and Luc Dendooven
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16S rRNA ,18S rRNA ,heavy metals ,bioreactor ,activated sludge ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Heavy metals are necessary at low concentration for biological activity, but they are often toxic for microorganisms at high concentrations. Amplicon sequencing of 16S rRNA and 18S rRNA was used to investigate changes in the bacterial and microeukaryotic communities in an activated sludge bioreactor incrementally contaminated with nickel (Ni), copper (Cu), and zinc (Zn) with an IC50 value ranging from 0% to 100%, as previously determined, while an uncontaminated bioreactor served as a control. The chemical oxygen demand (COD) was on average 90% in the uncontaminated bioreactor but dropped to 49% when the heavy metal concentration was 100% IC50. The bacterial community in the uncontaminated bioreactor was dominated by Alphaproteobacteria (mostly Agrobacterium and Brevundimonas) when the heavy metal concentrations were low and Bacteroidetes (mostly Sphingobacterium) when the highest amounts of heavy metal concentrations were applied. The members of Ciliophora, Ascomycota, and Basidiomycota alternatively dominated in the uncontaminated bioreactor, while Ascomycota (mostly Fusarium) dominated in the contaminated bioreactor. The results revealed that increased concentrations of Ni, Cu, and Zn altered the bacterial and microeukaryotic communities and some putative metabolic functions.
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- 2023
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21. Nanocatalytic performance of pectinase immobilized over in situ prepared magnetic nanoparticles
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Diego E. Navarro-López, Alvaro R. Bautista-Ayala, Maria Fernanda Rosales-De la Cruz, Selina Martínez-Beltrán, Diego E. Rojas-Torres, A. Sanchez-Martinez, O. Ceballos-Sanchez, J.A. Jáuregui-Jáuregui, Luis Marcelo Lozano, M. Sepúlveda-Villegas, Naveen Tiwari, and Edgar R. López-Mena
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Pectinase ,Enzyme immobilization ,Magnetic nanoparticles ,Cross-linking ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Immobilization of enzymes is one of the protein engineering methods used to improve their thermal and long-term stabilities. Immobilized pectinase has become an essential biocatalyst for optimization in the food processing industry. Herein, nanostructured magnetic nanoparticles were prepared in situ for use as supports to immobilize pectinase. The structural, morphological, optical and magnetic features and the chemical compositions of the nanoparticles were characterized. Nanoparticle agglomeration and low porosity were observed due to the synthetic conditions. These nanoparticles exhibited superparamagnetic behavior, which is desirable for biotechnological applications. The maximum retention rate for the enzyme was observed at pH 4.5 with a value of 1179.3 U/mgNP (units per milligram of nanoparticle), which was equivalent to a 65.6% efficiency. The free and immobilized pectinase were affected by the pH and temperature. The long-term instability caused 40% and 32% decreases in the specific activities of the free and immobilized pectinase, respectively. The effects of immobilization were analyzed with kinetic and thermodynamic studies. These results indicated a significant affinity for the substrate, a decreased reaction rate, and improved thermal stability of the immobilized pectinase. The reusability of the immobilized pectinase was preserved effectively during cycling, with only a 21.2% decrease in activity observed from the first to the last use. Therefore, alternative magnetic nanoparticles are presented for immobilizing and maintaining the thermostability of pectinase.
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- 2023
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22. Efficient stabilization of cyanonaphthalene by fast radiative cooling and implications for the resilience of small PAHs in interstellar clouds
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Mark H. Stockett, James N. Bull, Henrik Cederquist, Suvasthika Indrajith, MingChao Ji, José E. Navarro Navarrete, Henning T. Schmidt, Henning Zettergren, and Boxing Zhu
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Science - Abstract
Abstract After decades of searching, astronomers have recently identified specific Polycyclic Aromatic Hydrocarbons (PAHs) in space. Remarkably, the observed abundance of cyanonaphthalene (CNN, C10H7CN) in the Taurus Molecular Cloud (TMC-1) is six orders of magnitude higher than expected from astrophysical modeling. Here, we report unimolecular dissociation and radiative cooling rate coefficients of the 1-CNN isomer in its cationic form. These results are based on measurements of the time-dependent neutral product emission rate and kinetic energy release distributions produced from an ensemble of internally excited 1-CNN+ studied in an environment similar to that in interstellar clouds. We find that Recurrent Fluorescence – radiative relaxation via thermally populated electronic excited states – efficiently stabilizes 1-CNN+, owing to a large enhancement of the electronic transition probability by vibronic coupling. Our results help explain the anomalous abundance of CNN in TMC-1 and challenge the widely accepted picture of rapid destruction of small PAHs in space.
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- 2023
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23. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV
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The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, C. Goetzmann, P. Juillot, A.-C. Le Bihan, P. Van Hove, S. Gadrat, S. Beauceron, N. Beaupere, G. Boudoul, S. Brochet, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, M. Vander Donckt, P. Verdier, S. Viret, Z. Tsamalaidze, C. Autermann, S. Beranek, B. Calpas, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, K. Klein, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, K. Padeken, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, S. Thüer, M. Weber, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. Haller, K. Heine, R. S. Höing, G. Kaussen, H. Kirschenmann, R. Klanner, R. Kogler, J. Lange, I. Marchesini, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, J. Sibille, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, D. Troendle, L. Vanelderen, C. Barth, C. Baus, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, A. Kornmayer, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, S. Röcker, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Anagnostou, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, A. Markou, C. Markou, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, E. Stiliaris, X. Aslanoglou, I. Evangelou, G. Flouris, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, E. Paradas, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, B. Radics, F. Sikler, V. Veszpremi, G. Vesztergombi, A. J. Zsigmond, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, M. Mittal, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, P. Saxena, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, K. Chatterjee, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, A. Modak, S. Mukherjee, D. Roy, S. Sarkar, M. Sharan, A. Abdulsalam, D. Dutta, S. Kailas, V. Kumar, A. K. Mohanty, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, R. M. Chatterjee, S. Ganguly, S. Ghosh, M. Guchait, A. Gurtu, G. Kole, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Grunewald, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, R. Travaglini, S. Albergo, M. Chiorboli, S. Costa, F. Giordano, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, S. Frosali, E. Gallo, S. Gonzi, V. Gori, P. Lenzi, M. Meschini, S. Paoletti, G. Sguazzoni, A. Tropiano, L. Benussi, S. Bianco, D. Piccolo, P. Fabbricatore, R. Musenich, S. Tosi, A. Benaglia, F. De Guio, L. Di Matteo, S. Fiorendi, S. Gennai, A. Ghezzi, P. Govoni, M. T. Lucchini, S. Malvezzi, R. A. Manzoni, A. Martelli, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, S. Buontempo, N. Cavallo, A. De Cosa, F. Fabozzi, A. O. M. Iorio, L. Lista, S. Meola, M. Merola, P. Paolucci, P. Azzi, N. Bacchetta, D. Bisello, A. Branca, R. Carlin, P. Checchia, T. Dorigo, U. Dosselli, M. Galanti, F. Gasparini, U. Gasparini, P. Giubilato, A. Gozzelino, M. Gulmini, K. Kanishchev, S. Lacaprara, I. Lazzizzera, M. Margoni, G. Maron, A. T. Meneguzzo, J. Pazzini, N. Pozzobon, P. Ronchese, F. Simonetto, E. Torassa, M. Tosi, S. Vanini, P. Zotto, A. Zucchetta, G. 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Clarida, K. Dilsiz, F. Duru, S. Griffiths, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, H. Ogul, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny, M. Murray, D. Noonan, S. Sanders, R. Stringer, J. S. Wood, A. F. Barfuss, I. Chakaberia, A. Ivanov, S. Khalil, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, F. Rebassoo, D. Wright, A. Baden, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, A. Apyan, G. Bauer, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, Y. Kim, M. Klute, Y. S. Lai, A. Levin, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Published
- 2022
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24. High-precision electron affinity of oxygen
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Moa K. Kristiansson, Kiattichart Chartkunchand, Gustav Eklund, Odd M. Hole, Emma K. Anderson, Nathalie de Ruette, Magdalena Kamińska, Najeeb Punnakayathil, José E. Navarro-Navarrete, Stefan Sigurdsson, Jon Grumer, Ansgar Simonsson, Mikael Björkhage, Stefan Rosén, Peter Reinhed, Mikael Blom, Anders Källberg, John D. Alexander, Henrik Cederquist, Henning Zettergren, Henning T. Schmidt, and Dag Hanstorp
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Science - Abstract
High-precision measurements are useful to find isotopic shifts and electron correlation. Here the authors measure electron affinity and hyperfine splitting of atomic oxygen with higher precision than previous studies.
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- 2022
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25. Corrigendum to ‘Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells’[Redox Biol 6(2015):174–182]
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A. Rodríguez-Hernández, E. Navarro-Villarán, R. González, S. Pereira, L.B. Soriano-De Castro, A. Sarrias-Giménez, L. Barrera-Pulido, J.M. Álamo-Martínez, A. Serrablo-Requejo, G. Blanco-Fernández, A. Nogales-Muñoz, A. Gila-Bohórquez, D. Pacheco, M.A. Torres-Nieto, J. Serrano-Díaz-Canedo, G. Suárez-Artacho, C. Bernal-Bellido, L.M. Marín-Gómez, J.A. Barcena, M.A. Gómez-Bravo, C.A. Padilla, F.J. Padillo, and J. Muntané
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Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Published
- 2023
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26. Bacterial Communities in the Rhizosphere of Common Bean Plants (Phaseolus vulgaris L.) Grown in an Arable Soil Amended with TiO2 Nanoparticles
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Gabriela Medina-Pérez, Laura Afanador-Barajas, Sergio Pérez-Ríos, Yendi E. Navarro-Noya, Marco Luna-Guido, Fabián Fernández-Luqueño, and Luc Dendooven
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bacterial community structure ,alpha and beta diversity ,rhizosphere soil ,agroecosystems and nanoparticles ,plant development ,Agriculture - Abstract
The use of nanoparticles, such as titanium dioxide (TiO2-NPs), has increased substantially over the years. Some of them will end up in the soil, where their effect on plants and the soil bacterial community needs to be studied to determine their possible environmental risks. In this paper, beans (Phaseolus vulgaris L.) were cultivated in soil with 0, 150, or 300 mg TiO2-NPs kg−1. Plant development, nodule formation, chlorophyl content, and the bacterial community were monitored in uncultivated, non-rhizosphere, and rhizosphere soils. TiO2-NPs did not affect the beans’ growth and their chlorophyl content, but they did increase bacterial diversity and had a significant effect on the bacterial community structure in the rhizosphere, but not in the bulk and non-rhizosphere soil. Although the relative abundance of most bacterial groups varied with the TiO2-NP application rate, the cultivation of the bean plants, or the exposure time, that of Acidobacteria decreased, while that of Planctomycetes increased in the TiO2-NP-amended soil. Many bacterial groups were affected by the cultivation of the bean plants, i.e., the relative abundance of Acidobacteria, Gemmatimonadetes, Deltaproteobacteria, and Firmicutes mostly decreased in the rhizosphere independent of the application of TiO2-NPs or the time of exposure, while most groups belonging to Actinobacteria, Bacteroidetes, Rhizobiaceae, Phyllobacteriaceae, and Sphingomonadaceae were enriched.
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- 2023
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27. Editorial: Germline development: From germline stem cells to gametes, Volume II
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Myon Hee Lee, Rosa E. Navarro, and Sung Min Han
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germline development ,germline stem cell ,differentiation ,sex determination ,gametogenesis ,Biology (General) ,QH301-705.5 - Published
- 2023
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28. Coherencia normativa y lógica deóntica. Comentario a José Juan Moreso, Lo normativo: variedades y variaciones
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Pablo E. Navarro
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lógica deóntica ,racionalidad ,existencia normativa ,jerarquía normativa ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Abstract
En este trabajo se analizan algunas de las principales ideas sobre lógica, racionalidad y normatividad, defendidas por José Juan Moreso en la segunda sección de su libro Lo normativo: variedades y variaciones. Para Moreso, la conexión entre existencia de normas y actos de promulgación es insuficiente para comprender el impacto motivacional de las normas, i.e., el modo en que ellas guían la conducta humana. Para este objetivo es necesario tomar en cuenta el principio kantiano ‹‹debe implica puede››, pero este principio lleva a descartar la existencia de normas incoherentes (ad impossibilia nemo tenetur). Cuatro posibles respuestas a este desafío de Moreso se analizan en este artículo: (i) una concepción abstracta de normas, independiente de la noción de prescripción, (ii) la introducción de un orden jerárquico en los sistemas aplicables, (iii)el rechazo del principio kantiano y (iv) la conexión entre coherencia y naturaleza jerárquica delos sistemas jurídicos.
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- 2022
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29. Application of ammonium to a N limited arable soil enriches a succession of bacteria typically found in the rhizosphere
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Mario Hernández-Guzmán, Valentín Pérez-Hernández, Yendi E. Navarro-Noya, Marco L. Luna-Guido, Nele Verhulst, Bram Govaerts, and Luc Dendooven
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Medicine ,Science - Abstract
Abstract Crop residue management and tillage are known to affect the soil bacterial community, but when and which bacterial groups are enriched by application of ammonium in soil under different agricultural practices from a semi-arid ecosystem is still poorly understood. Soil was sampled from a long-term agronomic experiment with conventional tilled beds and crop residue retention (CT treatment), permanent beds with crop residue burned (PBB treatment) or retained (PBC) left unfertilized or fertilized with 300 kg urea-N ha−1 and cultivated with wheat (Triticum durum L.)/maize (Zea mays L.) rotation. Soil samples, fertilized or unfertilized, were amended or not (control) with a solution of (NH4)2SO4 (300 kg N ha−1) and were incubated aerobically at 25 ± 2 °C for 56 days, while CO2 emission, mineral N and the bacterial community were monitored. Application of NH4 + significantly increased the C mineralization independent of tillage-residue management or N fertilizer. Oxidation of NH4 + and NO2 − was faster in the fertilized soil than in the unfertilized soil. The relative abundance of Nitrosovibrio, the sole ammonium oxidizer detected, was higher in the fertilized than in the unfertilized soil; and similarly, that of Nitrospira, the sole nitrite oxidizer. Application of NH4 + enriched Pseudomonas, Flavisolibacter, Enterobacter and Pseudoxanthomonas in the first week and Rheinheimera, Acinetobacter and Achromobacter between day 7 and 28. The application of ammonium to a soil cultivated with wheat and maize enriched a sequence of bacterial genera characterized as rhizospheric and/or endophytic independent of the application of urea, retention or burning of the crop residue, or tillage.
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- 2022
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30. Silver and Hematite Nanoparticles Had a Limited Effect on the Bacterial Community Structure in Soil Cultivated with Phaseolus vulgaris L.
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Karla E. Zarco-González, Jessica D. Valle-García, Yendi E. Navarro-Noya, Fabián Fernández-Luqueño, and Luc Dendooven
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nanotoxicology ,ecotoxicology ,soil microbiome ,nanomaterials ,iron-based nanomaterial ,Agriculture - Abstract
The amount of nanoparticles that enters the environment has increased substantially in the last years. How they might affect plant characteristics and the bacterial community structure when they enter the soil, however, is still debated, as there is a continuous interaction between them. In this study, we determined the effect of silver (Ag-NPs) and hematite (α-Fe2O3-NPs) nanoparticles (0.15 g kg−1) on the characteristics of common bean (Phaseolus vulgaris L.) and the rhizosphere, non-rhizosphere and uncultivated soil bacterial community. The application of Ag-NPs or α-Fe2O3-NPs did not affect plant growth, but changed the amount of some heavy metals in the roots and aerial parts. The application of nanoparticles had a limited effect on the diversity, structure and functional profile of the soil and rhizosphere bacterial communities, but they were altered by cultivation of the bean plants and changed over time. It was found that application of Ag-NPs or α-Fe2O3-NPs had no effect on bean plant growth and only a small effect on the bacterial community structure and its putative metabolic functions. These findings show that in a complex system, such as a soil, different factors might affect the bacterial community structure and alter the possible effect of nanoparticles on it.
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- 2023
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31. Identification and Characterization of Beneficial Soil Microbial Strains for the Formulation of Biofertilizers Based on Native Plant Growth-Promoting Microorganisms Isolated from Northern Mexico
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Carlos Esteban Guardiola-Márquez, María Teresa Santos-Ramírez, Melina Lizeth Figueroa-Montes, Eric Oswaldo Valencia-de los Cobos, Iván Jesús Stamatis-Félix, Diego E. Navarro-López, and Daniel A. Jacobo-Velázquez
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bacteria ,beneficial microorganisms ,biofertilizers ,fungi ,native microbial strains ,plant growth-promoting microorganisms ,Botany ,QK1-989 - Abstract
Plant growth-promoting microorganisms (PGPM) benefit plant health by enhancing plant nutrient-use efficiency and protecting plants against biotic and abiotic stresses. This study aimed to isolate and characterize autochthonous PGPM from important agri-food crops and nonagricultural plants to formulate biofertilizers. Native microorganisms were isolated and evaluated for PGP traits (K, P, and Zn solubilization, N2-fixation, NH3-, IAA and siderophore production, and antifungal activity against Fusarium oxysporum). Isolates were tested on radish and broccoli seedlings, evaluating 19 individual isolates and 12 microbial consortia. Potential bacteria were identified through DNA sequencing. In total, 798 bacteria and 209 fungi were isolated. Isolates showed higher mineral solubilization activity than other mechanisms; 399 bacteria and 156 fungi presented mineral solubilization. Bacteria were relevant for nitrogen fixation, siderophore, IAA (29–176 mg/L), and ammonia production, while fungi for Fusarium growth inhibition (40–69%). Twenty-four bacteria and eighteen fungi were selected for their PGP traits. Bacteria had significantly (ANOVA, p < 0.05) better effects on plants than fungi; treatments improved plant height (23.06–51.32%), leaf diameter (25.43–82.91%), and fresh weight (54.18–85.45%) in both crops. Most potential species belonged to Pseudomonas, Pantoea, Serratia, and Rahnella genera. This work validated a high-throughput approach to screening hundreds of rhizospheric microorganisms with PGP potential isolated from rhizospheric samples.
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- 2023
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32. Antimicrobial, Cytotoxic, and Anti-Inflammatory Activities of Tigridia vanhouttei Extracts
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Jorge L. Mejía-Méndez, Ana C. Lorenzo-Leal, Horacio Bach, Edgar R. López-Mena, Diego E. Navarro-López, Luis R. Hernández, Zaida N. Juárez, and Eugenio Sánchez-Arreola
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traditional medicine ,Iridaceae ,Iris ,Tigridia vanhouttei ,biological activities ,Botany ,QK1-989 - Abstract
In this work, bulb extracts of Tigridia vanhouttei were obtained by maceration with solvents of increasing polarity. The extracts were evaluated against a panel of pathogenic bacterial and fungal strains using the minimal inhibitory concentration (MIC) assay. The cytotoxicity of the extracts was tested against two cell lines (THP-1 and A549) using the MTT assay. The anti-inflammatory activity of the extracts was evaluated in THP-1 cells by measuring the secretion of pro-inflammatory (IL-6 and TNF-α) and anti-inflammatory (IL-10) cytokines by ELISA. The chemical composition of the extracts was recorded by FTIR spectroscopy, and their chemical profiles were evaluated using GC-MS. The results revealed that only hexane extract inhibited the growth of the clinical isolate of Pseudomonas aeruginosa at 200 μg/mL. Against THP-1 cells, hexane and chloroform extracts were moderately cytotoxic, as they exhibited LC50 values of 90.16, and 46.42 μg/mL, respectively. Treatment with methanol extract was weakly cytotoxic at LC50 443.12 μg/mL against the same cell line. Against the A549 cell line, hexane, chloroform, and methanol extracts were weakly cytotoxic because of their LC50 values: 294.77, 1472.37, and 843.12 μg/mL. The FTIR analysis suggested the presence of natural products were confirmed by carboxylic acids, ketones, hydroxyl groups, or esters. The GC-MS profile of extracts revealed the presence of phytosterols, tetracyclic triterpenes, multiple fatty acids, and sugars. This report confirms the antimicrobial, cytotoxic, and anti-inflammatory activities of T. vanhouttei.
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- 2023
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33. Nitrogen Fertilizer Application Alters the Root Endophyte Bacterial Microbiome in Maize Plants, but Not in the Stem or Rhizosphere Soil
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Alejandra Miranda-Carrazco, Yendi E. Navarro-Noya, Bram Govaerts, Nele Verhulst, and Luc Dendooven
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agricultural practices ,bacterial community structure ,DArT-seq ,functionality of maize bacterial community ,genes involved in N cycling ,Microbiology ,QR1-502 - Abstract
ABSTRACT Plant-associated microorganisms that affect plant development, their composition, and their functionality are determined by the host, soil conditions, and agricultural practices. How agricultural practices affect the rhizosphere microbiome has been well studied, but less is known about how they might affect plant endophytes. In this study, the metagenomic DNA from the rhizosphere and endophyte communities of root and stem of maize plants was extracted and sequenced with the “diversity arrays technology sequencing,” while the bacterial community and functionality (organized by subsystems from general to specific functions) were investigated in crops cultivated with or without tillage and with or without N fertilizer application. Tillage had a small significant effect on the bacterial community in the rhizosphere, but N fertilizer had a highly significant effect on the roots, but not on the rhizosphere or stem. The relative abundance of many bacterial species was significantly different in the roots and stem of fertilized maize plants, but not in the unfertilized ones. The abundance of N cycle genes was affected by N fertilization application, most accentuated in the roots. How these changes in bacterial composition and N genes composition might affect plant development or crop yields has still to be unraveled. IMPORTANCE We investigated the bacterial community structure in the rhizosphere, root, and stem of maize plants cultivated under different agricultural techniques, i.e., with or without N fertilization, and with or without tillage. We found that the bacterial community was defined mostly by the plant compartment and less by agricultural techniques. In the roots, N fertilizer application affected the bacterial community structure, the microbiome functionality, and the abundance of genes involved in the N cycle, but the effect in the rhizosphere and stem was much smaller. Contrary, tillage did not affect the maize microbiome. This study enriches our knowledge about the plant-microbiome system and how N fertilization application affected it.
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- 2022
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34. ON RAIN INFORMATION AS MAP FEATURES FOR CAR NAVIGATION SYSTEMS
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M. Gebert, T. Berroth, and J.-E. Navarro-Barrientos
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
In this paper we present a design concept, architecture and implementation of a microservice to process and integrate rain information into a car navigation system in the form of rain map features. Two different input data sources are considered: QuadTile JSON format and GeoTIFF images. Our system converts this input data into an ouput GeoJSON format with only the most relevant information for the map overlay system in the navigation system of the car. We discuss different options for the cloud appearance, like color, shape and transparency. We present our microservices architecture together with data pipelines and implementation. Our approach allows for low latency and spare computing resources, which are especially needed in embedded systems. Finally, we discuss the advantages and disadvantages of our approach as well as further work.
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- 2021
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35. Tratamiento con glucocorticoides en pacientes con inflamación relacionada a angiopatía amiloide cerebral: ¿qué tan útil son?
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Yelson A. Picón-Jaimes, Valentina Mendoza-Gallego, Ernesto Jaramillo-Valenzuela, Angie L. Monroy-Martínez, Andrés D. Ortega-Ovalle, Freddy E. Navarro-Bautista, Andrea P. Contreras-Castillo, and Hernando J. Marín-Calderón
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corticoesteroides ,inflamación ,angiopatía amiloide cerebral ,demencia vascular ,enfermedad de alzheimer ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Objetivo. El objetivo de esta revisión consiste en analizar la evidencia más reciente sobre la utilidad de los glucocorticoides en pacientes con Inflamación relacionada a Angiopatía Amiloide Cerebral (IrAAC). Métodos. Revisión sistemática. Se llevó a cabo una búsqueda bibliográfica en los motores de búsqueda y bases de datos bases de datos PubMed, ScienceDirect, Embase, EBSCO y MEDLINE, incluyendo cualquier artículo relacionado con la evaluación de la utilidad, eficacia o seguridad de los glucocorticoides sobre la inflamación de angiopatía amiloide cerebral, sería incluido, dando prioridad a los estudios originales y a las revisiones sistemáticas y meta-análisis. Resultados. Se encontró que, la evidencia actual sobre su uso es limitada, derivando principalmente de casos reporte, series de casos y estudios retrospectivos. No obstante, parece ser que estos agentes ocasionan una respuesta favorable con solución parcial de las manifestaciones neurológicas de manera inmediata y/o progresiva a mediano y largo plazo, así como de los cambios anormales imagenológicos, dados por edema vasogénico y microsangrados corticales y subcorticales, aunque la mejoría de este último, no es muy marcado. Conclusión. La evidencia actual sobre el uso de glucocorticoides y su impacto sobre desenlaces clínicos y neuroimagenológicos es limitada.
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- 2022
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36. PO.1.7 Urinary metabolomic profile of systemic lupus erythematosus and lupus nephritis based on liquid and gas chromatography/mass spectrometry (LC-QTOF-MS and GC-QTOF-MS)
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A Rojo Sánchez, A Carmona Marte, M Santamaría Torres, Y Díaz Olmos, G Aroca Martínez, E Navarro Quiroz, M Cala Molina, and L Pacheco Lugo
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2022
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37. Design of a Novel Auxiliary Diagnostic Test for the Determination of Authenticity of Tequila 100% Agave Silver Class Based on Chemometrics Analysis of the Isotopic Fingerprint of the Beverage
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Rocío Fonseca-Aguiñaga, Uriel E. Navarro-Arteaga, Martin Muñoz-Sánchez, Humberto Gómez-Ruiz, Walter M. Warren-Vega, and Luis A. Romero-Cano
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isotopic fingerprint of Tequila ,authenticity of Mexican alcoholic beverages ,agave ,appellation of origin ,Chemical technology ,TP1-1185 - Abstract
The present research shows a robust isotopic ratio characterization of Carbon-13 (δ13CVPDB) in congeneric compounds such as methanol, n-propanol, isoamyl alcohol, ethyl lactate, ethyl acetate, ethanol, and acetaldehyde in representative samples (n = 69) of Tequila 100% agave silver class (TSC), employing gas chromatography/combustion/isotope-ratio mass spectrometry (GC/C/IRMS). From the information obtained, the construction of a radial plot attributable to the isotopic fingerprint of TSC was achieved. With this information, a diagnostic test was designed to determine the authenticity of TSC, comparing alcoholic beverages from other agave species as non-authentic samples. The sensitivity of the test was 94.2%; the specificity was 83.3%. Additionally, non-authentic samples were analyzed that meet all the criteria established in the regulations. The results obtained show that the GC/C/IRMS analytical technique and designed diagnostic test are useful as auxiliary parameters to determine the authenticity of the beverage, thus managing to determine the adulteration or falsification of the product.
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- 2023
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38. Biological Activities and Chemical Profiles of Kalanchoe fedtschenkoi Extracts
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Jorge L. Mejía-Méndez, Horacio Bach, Ana C. Lorenzo-Leal, Diego E. Navarro-López, Edgar R. López-Mena, Luis Ricardo Hernández, and Eugenio Sánchez-Arreola
- Subjects
traditional medicine ,Crassulaceae ,Kalanchoe fedtschenkoi ,bioactivities ,antimicrobial ,cytotoxicity ,Botany ,QK1-989 - Abstract
In this study, the leaves of Kalanchoe fedtschenkoi were consecutively macerated with hexane, chloroform, and methanol. These extracts were used to assess the bioactivities of the plant. The antimicrobial activity was tested against a panel of Gram-positive and -negative pathogenic bacterial and fungal strains using the microdilution method. The cytotoxicity of K. fedtschenkoi extracts was investigated using human-derived macrophage THP-1 cells through the MTT assay. Finally, the anti-inflammatory activity of extracts was studied using the same cell line by measuring the secretion of IL-10 and IL-6. The phytoconstituents of hexane and chloroform extracts were evaluated using gas chromatography–mass spectrometry (GC/MS). In addition, high-performance liquid chromatography (HPLC) was used to study the phytochemical content of methanol extract. The total flavonoid content (TFC) of methanol extract is also reported. The chemical composition of K. fedtschenkoi extracts was evaluated using Fourier-transform infrared spectroscopy (FTIR). Results revealed that the chloroform extract inhibited the growth of Pseudomonas aeruginosa at 150 μg/mL. At the same concentration, methanol extract inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA). Regarding their cytotoxicity, the three extracts were highly cytotoxic against the tested cell line at IC50 < 3 μg/mL. In addition, the chloroform extract significantly stimulated the secretion of IL-10 at 50 μg/mL (p < 0.01). GC/MS analyses revealed that hexane and chloroform extracts contain fatty acids, sterols, vitamin E, and triterpenes. The HPLC analysis demonstrated that methanol extract was constituted by quercetin and kaempferol derivatives. This is the first report in which the bioactivities and chemical profiles of K. fedtschenkoi are assessed for non-polar and polar extracts.
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- 2023
- Full Text
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39. Impact of a bacterial consortium on the soil bacterial community structure and maize (Zea mays L.) cultivation
- Author
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Laura N. Afanador-Barajas, Yendi E. Navarro-Noya, Marco L. Luna-Guido, and Luc Dendooven
- Subjects
Medicine ,Science - Abstract
Abstract Microorganisms are often applied as biofertilizer to crops to stimulate plant growth, increase yields and reduce inorganic N application. The survival and proliferation of these allochthonous microorganisms in soil is a necessary requisite for them to promote plant growth. We applied a sterilized or unsterilized not commercialized bacterial consortium mixed with cow manure leachate used by a farmer as biofertilizer to maize (Zea mays L.) in a greenhouse experiment, while maize development and the bacterial community structure was determined just before the biofertilizer was applied a first time (day 44), after three applications (day 89) and after six application at the end of the experiment (day 130). Application of sterilized or unsterilized biofertilizer with pH 4.3 and 864 mg NH4 +-N kg−1 had no significant effect on maize growth. The application of the biofertilizer dominated by Lactobacillus (relative abundance 11.90%) or the sterilized biofertilizer changed the relative abundance of a limited number of bacterial groups, i.e. Delftia, Halomonas, Lactobacillus and Stenotrophomonas, without altering significantly the bacterial community structure. Cultivation of maize, however, affected significantly the bacterial community structure, which showed large significant variations over time in the cultivated and uncultivated soil. It was concluded that the bacteria applied as a biofertilizer had only a limited effect on the relative abundance of these groups in uncultivated or soil cultivated with maize.
- Published
- 2021
- Full Text
- View/download PDF
40. High-resolution measurement of the electron affinity of cesium
- Author
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Navarrete, Jose E. Navarro, Nichols, Miranda, Ringvall-Moberg, Annie, Welander, Jakob, Lu, Di, Leimbach, David, Kristiansson, Moa K., Eklund, Gustav, Raveesh, Meena, Chulkov, Ruslan, Zhaunerchyk, Vitali, Hanstorp, Dag, Navarrete, Jose E. Navarro, Nichols, Miranda, Ringvall-Moberg, Annie, Welander, Jakob, Lu, Di, Leimbach, David, Kristiansson, Moa K., Eklund, Gustav, Raveesh, Meena, Chulkov, Ruslan, Zhaunerchyk, Vitali, and Hanstorp, Dag
- Abstract
Negative ions are unique quantum systems where electron correlation plays a decisive role in determining their properties. The lack of optically allowed transitions prevents traditional optical spectroscopy and the electron affinity is, therefore, for most elements, the only atomic quantity that can be determined with high accuracy. In this work, we present a high-precision experimental determination of the electron affinity of cesium. A collinear laser-ion beam apparatus was used to investigate the partial photodetachment cross section for the cesium anion, leaving the neutral atom in the 6p2P3/2 excited state. A resonance ionization scheme was used to obtain final-state selectivity, which enabled the investigation of a sharp onset of the cross section associated with a Wigner s-wave threshold behavior. The electron affinity was determined to be 0.471 598 3(38) eV.
- Published
- 2024
- Full Text
- View/download PDF
41. Eugenio Bulygin: In memoriam
- Author
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Pablo E. Navarro
- Subjects
Philosophy (General) ,B1-5802 - Published
- 2021
- Full Text
- View/download PDF
42. Observation of the rare $B^0_s\to\mu^+\mu^-$ decay from the combined analysis of CMS and LHCb data
- Author
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CMS, The, Collaborations, LHCb, Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Friedl, M., Frühwirth, R., Ghete, V. M., Hartl, C., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Krätschmer, I., Liko, D., Mikulec, I., Rabady, D., Rahbaran, B., Rohringer, H., Schöfbeck, R., Strauss, J., Treberer-Treberspurg, W., Waltenberger, W., Wulz, C. -E., Mossolov, V., Shumeiko, N., Gonzalez, J. Suarez, Alderweireldt, S., Bansal, S., Cornelis, T., De Wolf, E. A., Janssen, X., Knutsson, A., Lauwers, J., Luyckx, S., Ochesanu, S., Rougny, R., Van De Klundert, M., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Blekman, F., Blyweert, S., D'Hondt, J., Daci, N., Heracleous, N., Keaveney, J., Lowette, S., Maes, M., Olbrechts, A., Python, Q., Strom, D., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Onsem, G. P., Villella, I., Caillol, C., Clerbaux, B., De Lentdecker, G., Dobur, D., Favart, L., Gay, A. P. R., Grebenyuk, A., Léonard, A., Mohammadi, A., Perniè, L., Randle-conde, A., Reis, T., Seva, T., Thomas, L., Velde, C. Vander, Vanlaer, P., Wang, J., Zenoni, F., Adler, V., Beernaert, K., Benucci, L., Cimmino, A., Costantini, S., Crucy, S., Dildick, S., Fagot, A., Garcia, G., Mccartin, J., Rios, A. A. Ocampo, Ryckbosch, D., Diblen, S. Salva, Sigamani, M., Strobbe, N., Thyssen, F., Tytgat, M., Yazgan, E., Zaganidis, N., Basegmez, S., Beluffi, C., Bruno, G., Castello, R., Caudron, A., Ceard, L., Da Silveira, G. G., Delaere, C., Pree, T. du, Favart, D., Forthomme, L., Giammanco, A., Hollar, J., Jafari, A., Jez, P., Komm, M., Lemaitre, V., Nuttens, C., Pagano, D., Perrini, L., Pin, A., Piotrzkowski, K., Popov, A., Quertenmont, L., Selvaggi, M., Marono, M. Vidal, Garcia, J. M. Vizan, Beliy, N., Caebergs, T., Daubie, E., Hammad, G. H., Júnior, W. L. Aldá, Alves, G. A., Brito, L., Junior, M. Correa Martins, Martins, T. Dos Reis, Herrera, C. Mora, Pol, M. E., Teles, P. Rebello, Carvalho, W., Chinellato, J., Custódio, A., Da Costa, E. M., Damiao, D. De Jesus, Martins, C. De Oliveira, De Souza, S. Fonseca, Malbouisson, H., Figueiredo, D. Matos, Mundim, L., Nogima, H., Da Silva, W. L. Prado, Santaolalla, J., Santoro, A., Sznajder, A., Manganote, E. J. Tonelli, Pereira, A. Vilela, Bernardes, C. A., Dogra, S., Tomei, T. R. Fernandez Perez, Gregores, E. M., Mercadante, P. G., Novaes, S. F., Padula, Sandra S., Aleksandrov, A., Genchev, V., Hadjiiska, R., Iaydjiev, P., Marinov, A., Piperov, S., Rodozov, M., Sultanov, G., Vutova, M., Dimitrov, A., Glushkov, I., Litov, L., Pavlov, B., Petkov, P., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Cheng, T., Du, R., Jiang, C. H., Plestina, R., Romeo, F., Tao, J., Wang, Z., Asawatangtrakuldee, C., Ban, Y., Li, Q., Liu, S., Mao, Y., Qian, S. J., Wang, D., Xu, Z., Zou, W., Avila, C., Cabrera, A., Sierra, L. F. Chaparro, Florez, C., Gomez, J. P., Moreno, B. Gomez, Sanabria, J. C., Godinovic, N., Lelas, D., Polic, D., Puljak, I., Antunovic, Z., Kovac, M., Brigljevic, V., Kadija, K., Luetic, J., Mekterovic, D., Sudic, L., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Bodlak, M., Finger, M., Finger Jr., M., Assran, Y., Kamel, A. Ellithi, Mahmoud, M. A., Radi, A., Kadastik, M., Murumaa, M., Raidal, M., Tiko, A., Eerola, P., Fedi, G., Voutilainen, M., Härkönen, J., Karimäki, V., Kinnunen, R., Kortelainen, M. J., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Luukka, P., Mäenpää, T., Peltola, T., Tuominen, E., Tuominiemi, J., Tuovinen, E., Wendland, L., Talvitie, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Favaro, C., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., de Monchenault, G. Hamel, Jarry, P., Locci, E., Malcles, J., Rander, J., Rosowsky, A., Titov, M., Baffioni, S., Beaudette, F., Busson, P., Charlot, C., Dahms, T., Dalchenko, M., Dobrzynski, L., Filipovic, N., Florent, A., de Cassagnac, R. Granier, Mastrolorenzo, L., Miné, P., Mironov, C., Naranjo, I. N., Nguyen, M., Ochando, C., Ortona, G., Paganini, P., Regnard, S., Salerno, R., Sauvan, J. B., Sirois, Y., Veelken, C., Yilmaz, Y., Zabi, A., Agram, J. -L., Andrea, J., Aubin, A., Bloch, D., Brom, J. -M., Chabert, E. C., Collard, C., Conte, E., Fontaine, J. -C., Gelé, D., Goerlach, U., Goetzmann, C., Bihan, A. -C. Le, Skovpen, K., Van Hove, P., Gadrat, S., Beauceron, S., Beaupere, N., Boudoul, G., Bouvier, E., Brochet, S., Montoya, C. A. Carrillo, Chasserat, J., Chierici, R., Contardo, D., Depasse, P., Mamouni, H. El, Fan, J., Fay, J., Gascon, S., Gouzevitch, M., Ille, B., Kurca, T., Lethuillier, M., Mirabito, L., Perries, S., Alvarez, J. D. Ruiz, Sabes, D., Sgandurra, L., Sordini, V., Donckt, M. Vander, Verdier, P., Viret, S., Xiao, H., Tsamalaidze, Z., Autermann, C., Beranek, S., Bontenackels, M., Edelhoff, M., Feld, L., Heister, A., Hindrichs, O., Klein, K., Ostapchuk, A., Raupach, F., Sammet, J., Schael, S., Schulte, J. F., Weber, H., Wittmer, B., Zhukov, V., Ata, M., Brodski, M., Dietz-Laursonn, E., Duchardt, D., Erdmann, M., Fischer, R., Güth, A., Hebbeker, T., Heidemann, C., Hoepfner, K., Klingebiel, D., Knutzen, S., Kreuzer, P., Merschmeyer, M., Meyer, A., Millet, P., Olschewski, M., Padeken, K., Papacz, P., Reithler, H., Schmitz, S. A., Sonnenschein, L., Teyssier, D., Thüer, S., Weber, M., Cherepanov, V., Erdogan, Y., Flügge, G., Geenen, H., Geisler, M., Ahmad, W. Haj, Hoehle, F., Kargoll, B., Kress, T., Kuessel, Y., Künsken, A., Lingemann, J., Nowack, A., Nugent, I. M., Pooth, O., Stahl, A., Martin, M. Aldaya, Asin, I., Bartosik, N., Behr, J., Behrens, U., Bell, A. J., Bethani, A., Borras, K., Burgmeier, A., Cakir, A., Calligaris, L., Campbell, A., Choudhury, S., Costanza, F., Pardos, C. Diez, Dolinska, G., Dooling, S., Dorland, T., Eckerlin, G., Eckstein, D., Eichhorn, T., Flucke, G., Garcia, J. Garay, Geiser, A., Gunnellini, P., Hauk, J., Hempel, M., Jung, H., Kalogeropoulos, A., Kasemann, M., Katsas, P., Kieseler, J., Kleinwort, C., Korol, I., Krücker, D., Lange, W., Leonard, J., Lipka, K., Lobanov, A., Lohmann, W., Lutz, B., Mankel, R., Marfin, I., Melzer-Pellmann, I. -A., Meyer, A. B., Mittag, G., Mnich, J., Mussgiller, A., Naumann-Emme, S., Nayak, A., Ntomari, E., Perrey, H., Pitzl, D., Placakyte, R., Raspereza, A., Cipriano, P. M. Ribeiro, Roland, B., Ron, E., Sahin, M. Ö., Salfeld-Nebgen, J., Saxena, P., Schoerner-Sadenius, T., Schröder, M., Seitz, C., Spannagel, S., Trevino, A. D. R. Vargas, Walsh, R., Wissing, C., Blobel, V., Vignali, M. Centis, Draeger, A. R., Erfle, J., Garutti, E., Goebel, K., Görner, M., Haller, J., Hoffmann, M., Höing, R. S., Junkes, A., Kirschenmann, H., Klanner, R., Kogler, R., Lange, J., Lapsien, T., Lenz, T., Marchesini, I., Ott, J., Peiffer, T., Perieanu, A., Pietsch, N., Poehlsen, J., Poehlsen, T., Rathjens, D., Sander, C., Schettler, H., Schleper, P., Schlieckau, E., Schmidt, A., Seidel, M., Sola, V., Stadie, H., Steinbrück, G., Troendle, D., Usai, E., Vanelderen, L., Vanhoefer, A., Barth, C., Baus, C., Berger, J., Böser, C., Butz, E., Chwalek, T., De Boer, W., Descroix, A., Dierlamm, A., Feindt, M., Frensch, F., Giffels, M., Gilbert, A., Hartmann, F., Hauth, T., Husemann, U., Katkov, I., Kornmayer, A., Kuznetsova, E., Pardo, P. Lobelle, Mozer, M. U., Müller, T., Müller, Th., Nürnberg, A., Quast, G., Rabbertz, K., Röcker, S., Simonis, H. J., Stober, F. M., Ulrich, R., Wagner-Kuhr, J., Wayand, S., Weiler, T., Wolf, R., Anagnostou, G., Daskalakis, G., Geralis, T., Giakoumopoulou, V. A., Kyriakis, A., Loukas, D., Markou, A., Markou, C., Psallidas, A., Topsis-Giotis, I., Agapitos, A., Kesisoglou, S., Panagiotou, A., Saoulidou, N., Stiliaris, E., Aslanoglou, X., Evangelou, I., Flouris, G., Foudas, C., Kokkas, P., Manthos, N., Papadopoulos, I., Paradas, E., Strologas, J., Bencze, G., Hajdu, C., Hidas, P., Horvath, D., Sikler, F., Veszpremi, V., Vesztergombi, G., Zsigmond, A. J., Beni, N., Czellar, S., Karancsi, J., Molnar, J., Palinkas, J., Szillasi, Z., Makovec, A., Raics, P., Trocsanyi, Z. L., Ujvari, B., Sahoo, N., Swain, S. K., Beri, S. B., Bhatnagar, V., Gupta, R., Bhawandeep, U., Kalsi, A. K., Kaur, M., Kumar, R., Mittal, M., Nishu, N., Singh, J. B., Kumar, Ashok, Kumar, Arun, Ahuja, S., Bhardwaj, A., Choudhary, B. C., Kumar, A., Malhotra, S., Naimuddin, M., Ranjan, K., Sharma, V., Banerjee, S., Bhattacharya, S., Chatterjee, K., Dutta, S., Gomber, B., Jain, Sa., Jain, Sh., Khurana, R., Modak, A., Mukherjee, S., Roy, D., Sarkar, S., Sharan, M., Abdulsalam, A., Dutta, D., Kailas, S., Kumar, V., Mohanty, A. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Bhowmik, S., Chatterjee, R. M., Dewanjee, R. K., Dugad, S., Ganguly, S., Ghosh, S., Guchait, M., Gurtu, A., Kole, G., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Mohanty, G. B., Parida, B., Sudhakar, K., Wickramage, N., Bakhshiansohi, H., Behnamian, H., Etesami, S. M., Fahim, A., Goldouzian, R., Khakzad, M., Najafabadi, M. Mohammadi, Naseri, M., Mehdiabadi, S. Paktinat, Hosseinabadi, F. Rezaei, Safarzadeh, B., Zeinali, M., Felcini, M., Grunewald, M., Abbrescia, M., Calabria, C., Chhibra, S. S., Colaleo, A., Creanza, D., De Filippis, N., De Palma, M., Fiore, L., Iaselli, G., Maggi, G., Maggi, M., My, S., Nuzzo, S., Pompili, A., Pugliese, G., Radogna, R., Selvaggi, G., Sharma, A., Silvestris, L., Venditti, R., Verwilligen, P., Abbiendi, G., Benvenuti, A. C., Bonacorsi, D., Braibant-Giacomelli, S., Brigliadori, L., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Codispoti, G., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Montanari, A., Navarria, F. L., Perrotta, A., Primavera, F., Rossi, A. M., Rovelli, T., Siroli, G. P., Tosi, N., Travaglini, R., Albergo, S., Cappello, G., Chiorboli, M., Costa, S., Giordano, F., Potenza, R., Tricomi, A., Tuve, C., Barbagli, G., Ciulli, V., Civinini, C., D'Alessandro, R., Focardi, E., Gallo, E., Gonzi, S., Gori, V., Lenzi, P., Meschini, M., Paoletti, S., Sguazzoni, G., Tropiano, A., Benussi, L., Bianco, S., Piccolo, D., Ferretti, R., Ferro, F., Vetere, M. Lo, Robutti, E., Tosi, S., Dinardo, M. E., Fiorendi, S., Gennai, S., Gerosa, R., Ghezzi, A., Govoni, P., Lucchini, M. T., Malvezzi, S., Manzoni, R. A., Martelli, A., Marzocchi, B., Menasce, D., Moroni, L., Paganoni, M., Pedrini, D., Ragazzi, S., Redaelli, N., de Fatis, T. Tabarelli, Buontempo, S., Cavallo, N., Di Guida, S., Fabozzi, F., Iorio, A. O. M., Lista, L., Meola, S., Merola, M., Paolucci, P., Azzi, P., Bacchetta, N., Bisello, D., Branca, A., Carlin, R., Checchia, P., Dall'Osso, M., Dorigo, T., Dosselli, U., Galanti, M., Gasparini, F., Gasparini, U., Giubilato, P., Gozzelino, A., Kanishchev, K., Lacaprara, S., Margoni, M., Meneguzzo, A. T., Pazzini, J., Pozzobon, N., Ronchese, P., Simonetto, F., Torassa, E., Tosi, M., Zotto, P., Zucchetta, A., Zumerle, G., Gabusi, M., Ratti, S. P., Re, V., Riccardi, C., Salvini, P., Vitulo, P., Biasini, M., Bilei, G. M., Ciangottini, D., Fanò, L., Lariccia, P., Mantovani, G., Menichelli, M., Saha, A., Santocchia, A., Spiezia, A., Androsov, K., Azzurri, P., Bagliesi, G., Bernardini, J., Boccali, T., Broccolo, G., Castaldi, R., Ciocci, M. A., Dell'Orso, R., Donato, S., Fiori, F., Foà, L., Giassi, A., Grippo, M. T., Ligabue, F., Lomtadze, T., Martini, L., Messineo, A., Moon, C. S., Palla, F., Rizzi, A., Savoy-Navarro, A., Serban, A. T., Spagnolo, P., Squillacioti, P., Tenchini, R., Tonelli, G., Venturi, A., Verdini, P. G., Vernieri, C., Barone, L., Cavallari, F., D'imperio, G., Del Re, D., Diemoz, M., Jorda, C., Longo, E., Margaroli, F., Meridiani, P., Micheli, F., Nourbakhsh, S., Organtini, G., Paramatti, R., Rahatlou, S., Rovelli, C., Santanastasio, F., Soffi, L., Traczyk, P., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Bellan, R., Biino, C., Cartiglia, N., Casasso, S., Costa, M., Degano, A., Demaria, N., Finco, L., Mariotti, C., Maselli, S., Migliore, E., Monaco, V., Musich, M., Obertino, M. M., Pacher, L., Pastrone, N., Pelliccioni, M., Angioni, G. L. Pinna, Potenza, A., Romero, A., Ruspa, M., Sacchi, R., Solano, A., Staiano, A., Tamponi, U., Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., Della Ricca, G., Gobbo, B., La Licata, C., Marone, M., Schizzi, A., Umer, T., Zanetti, A., Chang, S., Kropivnitskaya, A., Nam, S. K., Kim, D. H., Kim, G. N., Kim, M. S., Kong, D. J., Lee, S., Oh, Y. D., Park, H., Sakharov, A., Son, D. C., Kim, T. J., Kim, J. Y., Song, S., Choi, S., Gyun, D., Hong, B., Jo, M., Kim, H., Kim, Y., Lee, B., Lee, K. S., Park, S. K., Roh, Y., Yoo, H. D., Choi, M., Kim, J. H., Park, I. C., Ryu, G., Ryu, M. S., Choi, Y., Choi, Y. K., Goh, J., Kim, D., Kwon, E., Lee, J., Yu, I., Juodagalvis, A., Komaragiri, J. R., Ali, M. A. B. Md, Linares, E. Casimiro, Castilla-Valdez, H., De La Cruz-Burelo, E., La Cruz, I. Heredia-de, Hernandez-Almada, A., Lopez-Fernandez, R., Sanchez-Hernandez, A., Moreno, S. Carrillo, Valencia, F. Vazquez, Pedraza, I., Ibarguen, H. A. Salazar, Pineda, A. Morelos, Krofcheck, D., Butler, P. H., Reucroft, S., Ahmad, A., Ahmad, M., Hassan, Q., Hoorani, H. R., Khan, W. 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Martín, Nicol, M., Robbe, P., Schune, M. -H., Teklishyn, M., Vallier, A., Viaud, B., Wormser, G., Ben-Haim, E., Charles, M., Coquereau, S., David, P., Del Buono, L., Henry, L., Polci, F., Albrecht, J., Brambach, T., Cauet, Ch., Deckenhoff, M., Eitschberger, U., Ekelhof, R., Gavardi, L., Kruse, F., Niet, R., Parkinson, C. J., Schlupp, M., Shires, A., Spaan, B., Swientek, S., Wishahi, J., Gutierrez, O. Aquines, Blouw, J., Britsch, M., Fontana, M., Popov, D., Schmelling, M., Volyanskyy, D., Zavertyaev, M., Bachmann, S., Bien, A., Comerma-Montells, A., De Cian, M., Dordei, F., Esen, S., Färber, C., Gersabeck, E., Grillo, L., Han, X., Hansmann-Menzemer, S., Jaeger, A., Kolpin, M., Kreplin, K., Krocker, G., Leverington, B., Marks, J., Meissner, M., Neuner, M., Nikodem, T., Seyfert, P., Stahl, M., Stahl, S., Uwer, U., Vesterinen, M., Wandernoth, S., Wiedner, D., Zhelezov, A., McNulty, R., Wallace, R., Zhang, W. C., Palano, A., Carbone, A., Falabella, A., Galli, D., Marconi, U., Moggi, N., Mussini, M., Perazzini, S., Vagnoni, V., Valenti, G., Zangoli, M., Bonivento, W., Cadeddu, S., Cardini, A., Cogoni, V., Contu, A., Lai, A., Liu, B., Manca, G., Oldeman, R., Saitta, B., Vacca, C., Andreotti, M., Baldini, W., Bozzi, C., Calabrese, R., Corvo, M., Fiore, M., Fiorini, M., Luppi, E., Pappalardo, L. L., Shapoval, I., Tellarini, G., Tomassetti, L., Vecchi, S., Anderlini, L., Bizzeti, A., Frosini, M., Graziani, G., Passaleva, G., Veltri, M., Bencivenni, G., Campana, P., De Simone, P., Lanfranchi, G., Palutan, M., Rama, M., Sarti, A., Sciascia, B., Gomez, R. Vazquez, Cardinale, R., Fontanelli, F., Gambetta, S., Patrignani, C., Petrolini, A., Pistone, A., Calvi, M., Cassina, L., Gotti, C., Khanji, B., Kucharczyk, M., Matteuzzi, C., Fu, J., Geraci, A., Neri, N., Palombo, F., Amerio, S., Collazuol, G., Gallorini, S., Gianelle, A., Lucchesi, D., Lupato, A., Morandin, M., Rotondo, M., Sestini, L., Simi, G., Stroili, R., Bedeschi, F., Cenci, R., Leo, S., Marino, P., Morello, M. J., Punzi, G., Stracka, S., Walsh, J., Carboni, G., Furfaro, E., Santovetti, E., Satta, A., Alves Jr, A. A., Auriemma, G., Bocci, V., Martellotti, G., Penso, G., Pinci, D., Santacesaria, R., Satriano, C., Sciubba, A., Dziurda, A., Kucewicz, W., Lesiak, T., Rachwal, B., Witek, M., Firlej, M., Fiutowski, T., Idzik, M., Morawski, P., Moron, J., Oblakowska-Mucha, A., Swientek, K., Szumlak, T., Batozskaya, V., Klimaszewski, K., Kurek, K., Szczekowski, M., Ukleja, A., Wislicki, W., Cojocariu, L., Giubega, L., Grecu, A., Maciuc, F., Orlandea, M., Popovici, B., Stoica, S., Straticiuc, M., Alkhazov, G., Bondar, N., Dzyuba, A., Maev, O., Sagidova, N., Shcheglov, Y., Belogurov, S., Belyaev, I., Egorychev, V., Golubkov, D., Kvaratskheliya, T., Machikhiliyan, I. V., Polyakov, I., Savrina, D., Semennikov, A., Zhokhov, A., Berezhnoy, A., Korolev, M., Leflat, A., Nikitin, N., Filippov, S., Gushchin, E., Kravchuk, L., Bondar, A., Eidelman, S., Krokovny, P., Kudryavtsev, V., Shekhtman, L., Vorobyev, V., Artamonov, A., Belous, K., Dzhelyadin, R., Guz, Yu., Novoselov, A., Obraztsov, V., Romanovsky, V., Shapkin, M., Stenyakin, O., Yushchenko, O., Badalov, A., Gomez, M. Calvo, Garrido, L., Gascon, D., Diaz, R. Graciani, Graugés, E., Benito, C. Marin, Olloqui, E. Picatoste, Molina, V. Rives, Ruiz, H., Vilasis-Cardona, X., Adeva, B., Cartelle, P. Alvarez, Suárez, A. Dosil, Albor, V. Fernandez, Torreira, A. Gallas, Pardiñas, J. García, Morata, J. A. Hernando, Casasus, M. Plo, Vidal, A. Romero, Silva, J. J. Saborido, Sedes, B. Sanmartin, Rios, C. Santamarina, Regueiro, P. Vazquez, Sierra, C. Vázquez, Diaz, M. Vieites, Alessio, F., Archilli, F., Barschel, C., Benson, S., Buytaert, J., Perez, D. Campora, Garcia, L. Castillo, Cattaneo, M., Charpentier, Ph., Vidal, X. Cid, Clemencic, M., Closier, J., Coco, V., Collins, P., Corti, G., Couturier, B., D'Ambrosio, C., Dettori, F., Di Canto, A., Dijkstra, H., Durante, P., Ferro-Luzzi, M., Forty, R., Frank, M., Frei, C., Gaspar, C., Gligorov, V. V., Cardoso, L. A. Granado, Gys, T., Haen, C., He, J., Head, T., van Herwijnen, E., Jacobsson, R., Johnson, D., Joram, C., Jost, B., Karacson, M., Karbach, T. M., Lacarrere, D., Langhans, B., Lindner, R., Linn, C., Lohn, S., Mapelli, A., Matev, R., Mathe, Z., Neubert, S., Neufeld, N., Otto, A., Panman, J., Altarelli, M. Pepe, Rauschmayr, N., Rihl, M., Roiser, S., Ruf, T., Schindler, H., Schmidt, B., Schopper, A., Schwemmer, R., Sridharan, S., Stagni, F., Subbiah, V. K., Teubert, F., Thomas, E., Tonelli, D., Trisovic, A., Garcia, M. Ubeda, Wicht, J., Wyllie, K., Battista, V., Bay, A., Blanc, F., Dorigo, M., Dupertuis, F., Fitzpatrick, C., Gianì, S., Haefeli, G., Jaton, P., Khurewathanakul, C., Komarov, I., La Thi, V. N., Lopez-March, N., Märki, R., Martinelli, M., Muster, B., Nakada, T., Nguyen, A. D., Nguyen, T. D., Nguyen-Mau, C., Prisciandaro, J., Navarro, A. Puig, Rakotomiaramanana, B., Rouvinet, J., Schneider, O., Soomro, F., Szczypka, P., Tobin, M., Tourneur, S., Tran, M. T., Veneziano, G., Bernet, R., Bowen, E., Bursche, A., Chiapolini, N., Chrzaszcz, M., Elsasser, Ch., Graverini, E., Lionetto, F., Lowdon, P., Müller, K., Serra, N., Steinkamp, O., Storaci, B., Straumann, U., Tresch, M., Vollhardt, A., Aaij, R., Ali, S., van Beuzekom, M., David, P. N. Y., De Bruyn, K., Farinelli, C., Heijne, V., Hulsbergen, W., Jans, E., Koppenburg, P., Kozlinskiy, A., van Leerdam, J., Merk, M., Oggero, S., Pellegrino, A., Snoek, H., van Tilburg, J., Tsopelas, P., Tuning, N., de Vries, J. A., Ketel, T., Koopman, R. F., Lambert, R. W., Santos, D. Martinez, Raven, G., Schiller, M., Syropoulos, V., Tolk, S., Dovbnya, A., Kandybei, S., Raniuk, I., Okhrimenko, O., Pugatch, V., Bifani, S., Farley, N., Griffith, P., Kenyon, I. R., Lazzeroni, C., Mazurov, A., McCarthy, J., Pescatore, L., Watson, N. K., Williams, M. P., Adinolfi, M., Benton, J., Brook, N. H., Cook, A., Coombes, M., Dalseno, J., Hampson, T., Harnew, S. T., Naik, P., Price, E., Prouve, C., Rademacker, J. H., Richards, S., Saunders, D. M., Skidmore, N., Souza, D., Velthuis, J. J., Voong, D., Barter, W., Bettler, M. -O., Cliff, H. V., Evans, H. -M., Tico, J. Garra, Gibson, V., Gregson, S., Haines, S. C., Jones, C. R., Sirendi, M., Ward, D. R., Wotton, S. A., Wright, S., Back, J. J., Blake, T., Craik, D. C., Crocombe, A. C., Dossett, D., Gershon, T., Kreps, M., Langenbruch, C., Latham, T., O'Hanlon, D. P., Pilař, T., Poluektov, A., Reid, M. M., Coutinho, R. Silva, Wallace, C., Whitehead, M., Easo, S., Nandakumar, R., Papanestis, A., Ricciardi, S., Wilson, F. F., Carson, L., Clarke, P. E. L., Cowan, G. A., Eisenhardt, S., Ferguson, D., Lambert, D., Luo, H., Morris, A. -B., Muheim, F., Needham, M., Playfer, S., Alexander, M., Beddow, J., Dean, C. -T., Eklund, L., Hynds, D., Karodia, S., Longstaff, I., Ogilvy, S., Pappagallo, M., Sail, P., Skillicorn, I., Soler, F. J. P., Spradlin, P., Affolder, A., Bowcock, T. J. V., Brown, H., Casse, G., Donleavy, S., Dreimanis, K., Farry, S., Fay, R., Hennessy, K., Hutchcroft, D., Liles, M., McSkelly, B., Patel, G. D., Price, J. D., Pritchard, A., Rinnert, K., Shears, T., Smith, N. A., Ciezarek, G., Cunliffe, S., Currie, R., Egede, U., Fol, P., Golutvin, A., Hall, S., McCann, M., Owen, P., Patel, M., Redi, F., Sepp, I., Smith, E., Sutcliffe, W., Websdale, D., Appleby, R. B., Barlow, R. J., Bird, T., Bjørnstad, P. M., Borghi, S., Brett, D., Brodzicka, J., Capriotti, L., Chen, S., De Capua, S., Dujany, G., Gersabeck, M., Harrison, J., Hombach, C., Klaver, S., Lafferty, G., McNab, A., Parkes, C., Pearce, A., Reichert, S., Rodrigues, E., Perez, P. Rodriguez, Smith, M., Cheung, S. -F., Derkach, D., Evans, T., Gauld, R., Greening, E., Harnew, N., Hill, D., Hunt, P., Hussain, N., Jalocha, J., John, M., Lupton, O., Malde, S., Stevenson, S., Thomas, C., Topp-Joergensen, S., Torr, N., Wilkinson, G., Counts, I., Ilten, P., Williams, M., Andreassen, R., Davis, A., De Silva, W., Meadows, B., Sokoloff, M. D., Sun, L., Todd, J., Andrews, J. E., Hamilton, B., Jawahery, A., Wimberley, J., Artuso, M., Blusk, S., Borgia, A., Britton, T., Ely, S., Gandini, P., Garofoli, J., Gui, B., Hadjivasiliou, C., Jurik, N., Kelsey, M., Mountain, R., Pal, B. K., Skwarnicki, T., Stone, S., Xing, Z., Zhang, L., Baesso, C., Torres, M. Cruz, Göbel, C., Rodriguez, J. Molina, Xie, Y., Milanes, D. A., Grünberg, O., Heß, M., Voß, C., Waldi, R., Likhomanenko, T., Malinin, A., Shevchenko, V., Ustyuzhanin, A., Vidal, F. Martinez, Oyanguren, A., Valls, P. Ruiz, Mayordomo, C. Sanchez, Onderwater, C. J. G., Wilschut, H. W., and Pesen, E.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
A joint measurement is presented of the branching fractions $B^0_s\to\mu^+\mu^-$ and $B^0\to\mu^+\mu^-$ in proton-proton collisions at the LHC by the CMS and LHCb experiments. The data samples were collected in 2011 at a centre-of-mass energy of 7 TeV, and in 2012 at 8 TeV. The combined analysis produces the first observation of the $B^0_s\to\mu^+\mu^-$ decay, with a statistical significance exceeding six standard deviations, and the best measurement of its branching fraction so far. Furthermore, evidence for the $B^0\to\mu^+\mu^-$ decay is obtained with a statistical significance of three standard deviations. The branching fraction measurements are statistically compatible with SM predictions and impose stringent constraints on several theories beyond the SM., Comment: Correspondence should be addressed to cms-and-lhcb-publication-committees@cern.ch
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- 2014
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43. Analysis of the lipid extraction performance in a cascade process for Scenedesmus almeriensis biorefinery
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I. Papachristou, S. Akaberi, A. Silve, E. Navarro-López, R. Wüstner, K. Leber, N. Nazarova, G. Müller, and W. Frey
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Microalgae ,Lipid extraction ,Enzymatic hydrolysis ,Pulsed electric fields ,Cascade processing ,Fuel ,TP315-360 ,Biotechnology ,TP248.13-248.65 - Abstract
Abstract Background Microalgae have attracted considerable interest due to their ability to produce a wide range of valuable compounds. Pulsed Electric Fields (PEF) has been demonstrated to effectively disrupt the microalgae cells and facilitate intracellular extraction. To increase the commercial viability of microalgae, the entire biomass should be exploited with different products extracted and valorized according to the biorefinery scheme. However, demonstrations of multiple component extraction in series are very limited in literature. This study aimed to develop an effective lipid extraction protocol from wet Scenedesmus almeriensis after PEF-treatment with 1.5 MJ·kgDW −1. A cascade process, i.e., the valorization of several products in row, was tested with firstly the collection of the released carbohydrates in the water fraction, then protein enzymatic hydrolysis and finally lipid extraction. Biomass processed with high pressure homogenization (HPH) on parallel, served as benchmark. Results Lipid extraction with ethanol:hexane (1:0.41 vol/vol) offered the highest yields from the different protocols tested. PEF-treatment promoted extraction with almost 70% of total lipids extracted against 43% from untreated biomass. An incubation step after PEF-treatment, further improved the yields, up to 83% of total lipids. Increasing the solvent volume by factor 2 offered no improvement. In comparison, extraction with two other systems utilizing only ethanol at room temperature or elevated at 60 °C were ineffective with less than 30% of total lipids extracted. Regarding cascade extraction, carbohydrate release after PEF was detected albeit in low concentrations. PEF-treated samples displayed slightly better kinetics during the enzymatic protein hydrolysis compared to untreated or HPH-treated biomass. The yields from a subsequent lipid extraction were not affected after PEF but were significantly increased for untreated samples (66% of total lipids), while HPH displayed the lowest yields (~ 49% of total lipids). Conclusions PEF-treatment successfully promoted lipid extraction from S. almeriensis but only in combination with a polar:neutral co-solvent (ethanol:hexane). After enzymatic protein hydrolysis in cascade processing; however, untreated biomass displayed equal lipid yields due to the disruptive effect of the proteolytic enzymes. Therefore, the positive impact of PEF in this scheme is limited on the improved reaction kinetics exhibited during the enzymatic hydrolysis step.
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- 2021
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44. The root endophytic bacterial community of Ricinus communis L. resembles the seeds community more than the rhizosphere bacteria independent of soil water content
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Stephanie E. Hereira-Pacheco, Yendi E. Navarro-Noya, and Luc Dendooven
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Medicine ,Science - Abstract
Abstract Rhizosphere and root endophytic bacteria are crucial for plant development, but the question remains if their composition is similar and how environmental conditions, such as water content, affect their resemblance. Ricinus communis L., a highly drought resistant plant, was used to study how varying soil water content affected the bacterial community in uncultivated, non-rhizosphere and rhizosphere soil, and in its roots. Additionally, the bacterial community structure was determined in the seeds of R. communis at the onset of the experiment. Plants were cultivated in soil at three different watering regimes, i.e. 50% water holding capacity (WHC) or adjusted to 50% WHC every two weeks or every month. Reducing the soil water content strongly reduced plant and root dry biomass and plant development, but had little effect on the bacterial community structure. The bacterial community structure was affected significantly by cultivation of R. communis and showed large variations over time. After 6 months, the root endophytic bacterial community resembled that in the seeds more than in the rhizosphere. It was found that water content had only a limited effect on the bacterial community structure and the different bacterial groups, but R. communis affected the bacterial community profoundly.
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- 2021
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45. In vitro determination of the immunosuppressive effect, internalization, and release mechanism of squalene-gusperimus nanoparticles for managing inflammatory responses
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Carlos E. Navarro Chica, Tian Qin, Bart J. de Haan, M.M Faas, Alexandra M. Smink, Ligia Sierra, Betty L. López, and Paul de Vos
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Squalene-gusperimus nanoparticles ,internalization mechanism ,release mechanism ,immunosuppressant ,low-density lipoprotein receptors mediated endocytosis ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Gusperimus is an anti-inflammatory drug that has shown to be effective in managing autoimmunity and preventing graft rejection. This is unstable and easily broken down into cytotoxic components. We encapsulated gusperimus binding it covalently to squalene obtaining squalene-gusperimus nanoparticles (Sq-GusNPs). These nanoparticles enhanced the immunosuppressive effect of gusperimus in both mouse macrophages and T cells. The half-maximal inhibitory concentration in macrophages was 9-fold lower for Sq-GusNPs compared with the free drug. The anti-inflammatory effect of the Sq-GusNPs was maintained over time without cytotoxicity. By studying nanoparticles uptake by cells with flow cytometry, we demonstrated that Sq-GusNPs are endocytosed by macrophages after binding to low-density lipoprotein receptors (LDLR). In presence of cathepsin B or D release of gusperimus is increased demonstrating the participation of proteases in the release process. Our approach may allow the application of Sq-GusNPs for effective management of inflammatory disorders including autoimmunity and graft rejection.
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- 2021
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46. Bacterial Communities in the Rhizosphere at Different Growth Stages of Maize Cultivated in Soil Under Conventional and Conservation Agricultural Practices
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Yendi E. Navarro-Noya, Yosef Chávez-Romero, Stephanie Hereira-Pacheco, Arit Seleny de León Lorenzana, Bram Govaerts, Nele Verhulst, and Luc Dendooven
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community assembly ,functional diversity ,intensive agricultural practices ,tillage ,sustainable agriculture ,plant microbiome ,Microbiology ,QR1-502 - Abstract
ABSTRACT Farmers in Mexico till soil intensively, remove crop residues for fodder and grow maize often in monoculture. Conservation agriculture (CA), including minimal tillage, crop residue retention and crop diversification, is proposed as a more sustainable alternative. In this study, we determined the effect of agricultural practices and the developing maize rhizosphere on soil bacterial communities. Bulk and maize (Zea mays L.) rhizosphere soil under conventional practices (CP) and CA were sampled during the vegetative, flowering and grain filling stage, and 16S rRNA metabarcoding was used to assess bacterial diversity and community structure. The functional diversity was inferred from the bacterial taxa using PICRUSt. Conservation agriculture positively affected taxonomic and functional diversity compared to CP. The agricultural practice was the most important factor in defining the structure of bacterial communities, even more so than rhizosphere and plant growth stage. The rhizosphere enriched fast growing copiotrophic bacteria, such as Rhizobiales, Sphingomonadales, Xanthomonadales, and Burkholderiales, while in the bulk soil of CP other copiotrophs were enriched, e.g., Halomonas and Bacillus. The bacterial community in the maize bulk soil resembled each other more than in the rhizosphere of CA and CP. The bacterial community structure, and taxonomic and functional diversity in the maize rhizosphere changed with maize development and the differences between the bulk soil and the rhizosphere were more accentuated when the plant aged. Although agricultural practices did not alter the effect of the rhizosphere on the soil bacterial communities in the flowering and grain filling stage, they did in the vegetative stage. IMPORTANCE We studied the effect of sustainable conservation agricultural practices versus intensive conventional ones on the soil microbial diversity, potential functionality, and community assembly in rhizosphere of maize cultivated in a semiarid environment. We found that conservation agriculture practices increased the diversity of soil microbial species and functions and strongly affected how they were structured compared to conventional practices. Microbes affected by the roots of maize, the rhizobiome, were different and more diverse than in the surrounding soil and their diversity increased when the plant grew. The agricultural practices affected the maize rhizobiome only in the early stages of growth, but this might have an important impact on the development of maize plant.
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- 2022
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47. Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women
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Liz Maria de Almeida, Sandra Cortés, Marta Vilensky, Olivia Valenzuela, Laura Cortes-Sanabria, Mirian de Souza, Rafael Alonso Barbeito, Eliana Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Andrea S. Llera, Bettina Müller, Osvaldo L. Podhajcer, Carlos Velazquez, Elsa Alcoba, Isabel Alonso, Alicia I. Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cristerna, Lucia Delgado, Marisa Dreyer Breitenbach, Elmer Fernández, Jorge Fernández, Wanda Fernández, Ramon A. Franco-Topete, Fancy Gaete, Jorge Gómez, Leivy P. Gonzalez-Ramirez, Marisol Guerrero, Susan A. Gutierrez-Rubio, Beatriz Jalfin, Alejandra Lopez-Vazquez, Dora Loria, Silvia Míguez, Andres de J. Moran-Mendoza, Gilberto Morgan-Villela, Carina Mussetti, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Rui M. Reis, Javier Retamales, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Laura Segovia, Juan M. Sendoya, Aida A. Silva-Garcia, Stella Viña, Livia Zagame, Beth Jones, Moysés Szklo, United States-Latin American Cancer Research Network (US-LACRN), Juan Abarca, Pamela Acevedo, Graciela Acosta, Ana Acosta, Gabriela Acosta Haab, Keyla Teresa Acosta-Torres, Marta Aghazarian, Carola Aguayo, Gustavo Alarcon-Lopez, Viviane Andrade, Wenceslao Angeles Bueno, Roberto Arai, Priscila Elvira Arambula-Barreras, Maria Isabel Arámburo-Rubio, Estrellita Araus, Gonzalo Ardao, Lilia A. Arellano-Jimenez, Felipe Argandoña, Claudia Arias, Ricardo Armisen, Mauricio Aspee, Rodrigo Assar, Itzel Reneé Astiazarán-Rascón, Sebastian Astorga, Maxwell Avilés-Rodrıguez, Antônio Bailão Junior, Adolfo E. Barragan-Curiel, Adelfo Barragan-Ruiz, Julia Bernachin, Wilfrido Bernal-Herrera, Renata Binato, Sarah Brnich, Claudio Bustamante, Miguel Angel Bustamante, Julio Bustos Gomez, Felipe de J. Bustos Rodriguez, Janett Caballero-Jasso, Angie Calfuman, Antonio Hugo, José Froes Marques Campos, Mónica Campos, Soledad Cano, Juan C. Canton-Romero, Paulina Carmona, Fernando Carrizo, Andre Lopes Carvalho, Erika Carvallo, Julio Carzoglio, Monica Casalnuovo, Benedicta Caserta, Alvaro Castillo, César Castillo, Juan M. Castro-Cervantes, Yascara Cerda, Roger Chammas, Mario Alberto Chavez-Zamudio, Loreto Chia, Daniela Chirico, Esther Cisneros-Quirarter, Minor Raul Cordero-Bautista, Valeria Cornejo, Baldemar Corral-Villegas, Andrés Cortés, German Salvador Cortez-Zamorano, Alejandro Corvalan, Adolfo Cruz, Alba d’Aurora, Sandra De la Fuente, Soledad De la Peña, Roberto de Leon-Caballero, César Del Castillo, Azucena Del-Toro-Valero, Mirtha Di Pretoro, Andrea Digonzelli, Jose El Ters, Paula Escobar, Marcela Estolaza, Adriane Feijo Evangelista, Marcelo Fanelli, Paulo Farias, Diego Flaks, Edgar G. Flores-Ayala, Maria R. Flores-Marquez, David Franco-Hughes, Karina Franco-Topete, Cristobal Fresno, Carolina Gabay, Mario Gallegos, Jorge Gamboa, Daiana Ganiewich, Carlos Garbovesky, Ricardo Garcia-Gaeta, Alma C. Garcia-Martinez, Rubén Alejandro Garcıa-Munguıa, Adriana Garibay-Escobar, Liliana Gimenez, Mariana M. Gomez-Del Toro, Germán González, César Osbaldo González Mondaca, Beatriz Gonzalez-Ulloa, Susana Gorostidy, Gonzalo Greif, Alfonso G. Guevara-Torres, Lorena Gutierrez, Adrián Hannois, Andrew Hart, Steffen Härtel, Marcos Henriquez, Miriam E Hernandez-Franco, Rafael Hernandez-Guevara, Manuel I Herrera-Miramontes, Graciela Horton, Gladys Ibañez, Martın Ipiña, Lilian Jara, Raul Jara, Maria Luisa Jaramillo, Beatriz Jardim, Maria Eugenia Jimenez, Victor M. Jimenez-Moreno, Hugo Ju, Nazareth Juárez Rusjan, Karen Juneman, Ligia Maria Kerr, Alejandra Krupelis, Guillermo Laviña, Fernando Lavista, Irma Leticia León-Duarte, Alberto Lescano, Verónica Lezano, Rossana Mendoza Lopez, Jose Guillermo López-Cervantes, Miguel Enrique Lopez-Muñoz, Francisca Lucena, Alejandra Luque, Alejandro Maass, Maria do Socorro Maciel, Silvina Maldonado, Flavia Rotea Mangone, Jorge Mansilla, Katherine Marcelain, Carolina Mariani, Marcia Maria Chiquitelli Marques, Reyna J Martinez-Arriaga, Hector R Martinez-Ramirez, Marcela Martins, Alma G Maya-Gonzalez, Mariana Menini, Soledad Milans, Soledad Montes, Ana Verónica Morales Hernández, Carla Morong, Eduardo Mussetti, Luis J Najar-Acosta, Elisa Napolitano e Ferreira, Nancy E Navarro Ruiz, Cristina Noblıa, João Soares Nunes, Fabiola Núñez, Nilton Onari, Emma M Oropeza-De Anda, David Ortega-Tirado, Miguel Angel Ortiz-Martinez, Cynthia Aparecida Bueno de Toledo Osório, Carlos Eduardo Paiva, Paulina Peñaloza, Miguel Peredo Navarro, David Pereira, Laura Perez-Michel, Francisca Pino, Tania Pino, Natalia Pinto, Jessica Pizarro, Jael Quintero, Antonio Quintero-Ramos, Enrique Ramirez, Gladys E Ramirez-Rosales, Claudia Ramis, Maritza Ramos Ramirez, Adela Rascon-Alcantar, Francois Richard, Omar Rios-Méndez, Ernesto Rivera-Claisse, Ramón E. Robles-Zepeda, Iara Santana Rocha, Natalia Rodriguez, Vilma Rodriguez, Maria Teresa Rodriguez, Diego Rodriguez-Gonzalez, Rosemeire A Roela, Ana M. Romero-Gomez, Ana M. Rosales-Sandoval, Lidia A. Rubio-Chavez, Omar V. Rubio-Plascencia, Florencia Russo, Gaciela Sabini, Isabel Saffie, Brenda Samaniego, Benito Sanchez-Llamas, Verónica Sanchotena, Daniel Sat-Muñoz, Mariana Savignano, Cristovam Scapulatempo Neto, Max Mano Senna, Carolina Silva, Jaime Silvera, Isabele Small, Fernando Soares, Iberê Soares, Silvana Soares dos Santos, Evandro Sobrosa de Mello, José Antonio Sola, Irene Sorın, Alejandra Sosa, Claudio Sosa, Cristiano de Pádua Souza, Lucıa Spangenberg, Gustavo Steffanof, Florencia Straminsky, Mónica Tapia, Raziel O. Tapia-Llanos, Geronimo M. Tavares-Macias, Veronica Terzieff, Vicente Teti, Javier Tognarelli, Verónica Toledo, Paulina Toro, Roberto Torres, Mariana Torres-Palomares, Alejandra Trinchero, Rogelio Troyo-San Roman, Hernan Urbano, Nicolas Vacca, Marıa Lourdes Valencia-Peña, Jaime Vazquez Nares, Ezequiel Velez-Gomez, Laura N. Venegas-Godinez, Ricardo Verdugo, René Aloisio da Costa Vieira, Manuel Isaac Villegas-Gómez, Silvia Vornetti, Anapaula H. U. Watanabe, Carlos Zamorano, Luis Zapata, and Zdenka Zlatar
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global excellence ,oncology ,Latin America ,breast cancer ,molecular subtypes ,risk factors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity.
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- 2022
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48. The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients
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Andrea Sabina Llera, Eliana Saul Furquim Werneck Abdelhay, Nora Artagaveytia, Adrián Daneri-Navarro, Bettina Müller, Carlos Velazquez, Elsa B. Alcoba, Isabel Alonso, Daniela B. Alves da Quinta, Renata Binato, Alicia Inés Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Juan M. Castro-Cervantes, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raúl Delgadillo-Cisterna, Lucía Delgado, Marisa Dreyer-Breitenbach, Laura Fejerman, Elmer A. Fernández, Jorge Fernández, Wanda Fernández, Ramón A. Franco-Topete, Carolina Gabay, Fancy Gaete, Adriana Garibay-Escobar, Jorge Gómez, Gonzalo Greif, Thomas G. Gross, Marisol Guerrero, Marianne K. Henderson, Miguel E. Lopez-Muñoz, Alejandra Lopez-Vazquez, Silvina Maldonado, Andrés J. Morán-Mendoza, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Miguel A. Ortiz-Martínez, Jael Quintero, Antonio Quintero-Ramos, Rui M. Reis, Javier Retamales, Ernesto Rivera-Claisse, Darío Rocha, Robinson Rodríguez, Cristina Rosales, Efrain Salas-González, Verónica Sanchotena, Laura Segovia, Juan Martín Sendoya, Aida A. Silva-García, Alejandra Trinchero, Olivia Valenzuela, Vidya Vedham, Livia Zagame, United States-Latin American Cancer Research Network (US-LACRN), Osvaldo L. Podhajcer, Juan Abarca, Pamela Acevedo, Graciela Acosta, Gissel Acosta, Gabriela Acosta Haab, Ana Lilian Acosta Silva, Marta Aghazarian, Carola Aguayo, Bernardo Aizen, Gustavo Alarcon Lopez, Liz Almeida, Ana Alvarez, Viviane Andrade, Wenceslao Angeles-Bueno, Roberto Arai, Priscila Elvira Arambula Barreras, Ma. Isabel Aramburo Rubio, Gonzalo Ardao, Lilia A. Arellano-Jimenez, Claudia Arias, Ricardo Armisen, Mauricio Aspee, Rodrigo Assar, Itzel Reneé Astiazarán Rascón, Sebastian Astorga, Maxwell Aviles Rodriguez, Antônio Bailão Junior, Adolfo E. Barragan-Curiel, Adelfo Barragan-Ruiz, Fernanda Bermudez, Julia Bernachin, Wilfrido Bernal Herrera, Mara Bonet, Sarah Brnich, Claudio Bustamante, Miguel Angel Bustamante, Julio Bustos-Gomez, Felipe de J Bustos-Rodriguez, Janett Caballero Jasso, Angie Calfuman, Antonio Hugo José Froes Marques, Mónica Campos, Soledad Cano, Juan C. Canton-Romero, Ricardo Cappetta, Paulina Carmona, Fernando Carrizo, André Lopes Carvalho, Erika Carvallo, Julio Carzoglio, Monica Casalnuovo, Benedicta Caserta, Alvaro Castillo, César Castillo, Roger Chammas, Mario Alberto Chavez Zamudio, Loreto Chia, Elisa Chiarello, Daniela Chirico, Esther Cisneros-Quirarter, Minor Raul Cordero Bautista, Valeria Cornejo, Baldemar Corral Villegas, Andrés Cortés, Sandra Cortés, Laura Cortes-Sanabria, German Salvador Cortez Zamorano, Alejandro Corvalan, Adolfo Cruz, Alba d'Aurora, Sandra De la Fuente, Soledad De la Peña, Roberto de Leon Caballero, Mirian de Souza, César Del Castillo, Azucena Del-Toro-Valero, Mirtha Di Pretoro, Andrea Digonzelli, Jose El Ters, Paula Escobar, Marcela Estolaza, Adriane Feijo Evangelista, Marcelo Fanelli, Paulo Farias, Graciela Fernandez, José R. Filassi, Natalia Filgueiras, Diego Flaks, Edgar G. Flores-Ayala, Maria R. Flores-Marquez, David Franco Hughes, Karina Franco-Topete, Jimena Freire, Cristobal Fresno, Romina Gabrielli, Mario Gallegos, Jorge Gamboa, Daiana Ganiewich, Carlos Garbovesky, Ruben Alejandro Garcia Munguia, Ricardo Garcia-Gaeta, Alma C. Garcia-Martinez, Liliana Gimenez, Hector Gómez Silveira, Mariana M. Gomez-Del Toro, Marcela Gonzalez, Alicia Gonzalez, Germán González, Cesar Osbaldo Gonzalez Mondaca, Leivy P. Gonzalez-Ramirez, Beatriz Gonzalez-Ulloa, Susana Gorostidy, Mariela Grass, Alfonso G. Guevara Torres, Lorena Gutierrez, Susan A. Gutierrez-Rubio, Adrián Hannois, Andrew Hart, Steffen Härtel, Marcos Henriquez, Rafael Hernandez Guevara, Miriam E. Hernandez-Franco, Manuel I. Herrera-Miramontes, Graciela Horton, Gladys Ibañez, Martín Ipiña, Beatriz Jalfin, Lilian Jara, Raul Jara, Maria Luisa Jaramillo, David Javalera-Castro, Maria Eugenia Jimenez, Hugo Ju, Nazareth Juárez Rusjan, Karen Juneman, Ligia Maria Kerr, Alejandra Krupelis, Flor Esmeralda Larios-Jimenez, Jose Domingo Latorre, Guillermo Laviña, Fernando Lavista, Irma Leticia León Duarte, Alberto Lescano, Verónica Lezano, Rossana Mendoza Lopez, Jose Guillermo Lopez Cervantes, Miguel Enrique Lopez Muñoz, Dora Loria, Alejandra Luque, Alejandro Maass, Maria do Socorro Maciel, Flavia Rotea Mangone, Jorge Mansilla, Katherine Marcelain, Carolina Mariani, Marcia Maria Chiquitelli Marques, Reyna J. Martinez-Arriaga, Hector R. Martinez-Ramirez, Marcela Martins, Alma G. Maya-Gonzalez, Brenda Mazzaferri, Yadira Medina-Mora, Mariana Menini, Silvia Míguez, Soledad Milans, Soledad Montes, Ana Verónica Morales Hernández, Giberto Morga-Villela, Carla Morong, Homero Muñoz, Ignacio Miguel Muse, Carina Mussetti, Eduardo Mussetti, Luis J. Najar-Acosta, Elisa Napolitano e Ferreira, Nancy E. Navarro-Ruiz, Cristina Noblía, João Soares Nunes, Daniela Núñez, Fabiola Núñez, Nilton Onari, Emma M. Oropeza-De Anda, David Ortega Tirado, Cynthia Aparecida Bueno de Toledo Osório, Carlos Eduardo Paiva, Paulina Peñaloza, Miguel Peredo-Navarro, David Pereira, Laura Perez Michel, Francisca Pino, Tania Pino, Natalia Pinto, Jessica Pizarro, Carlos Pressa, Enrique Ramirez, Gladys E. Ramirez-Rosales, Claudia Ramis, Maritza Ramos-Ramirez, Adela Rascon Alcantar, Silvana Ravaglio, Francois Richard, Omar Rios Méndez, Ramón Enrique Robles Zepeda, Iara Santana Rocha, Natalia Rodriguez, Vilma Rodriguez, Maria Teresa Rodriguez, Diego Rodriguez-Gonzalez, Rosemeire A Roela, Ana M Romero-Gomez, Ana M Rosales-Sandoval, Omar V Rubio-Plascencia, Florencia Russo, Gaciela Sabini, Isabel Saffie, Helena Salina Dias, Brenda Guadalupe Samaniego Soto, Julio San Martino, Benito Sanchez-Llamas, Daniel Sat-Muñoz, Mariana Savignano, Cristovam Scapulatempo Neto, Max Mano Senna, Carolina Silva, Jaime Silvera, Isabele Small, Fernando Soares, Iberê Soares, Silvana Soares dos Santos, Evandro Sobrosa de Mello, José Antonio Sola, Irene Sorín, Alejandra Sosa, Anabella Sosa, Claudio Sosa, Sandra Soto, Cristiano de Pádua Souza, Lucía Spangenberg, Gustavo Steffanof, Florencia Straminsky, Mónica Tapia, Raziel O. Tapia-Llanos, Geronimo M. Tavares-Macias, Guillermo Temperley, Veronica Terzieff, Vicente Teti, Javier Tognarelli, Verónica Toledo, Paulina Toro, Roberto Torres, Mariana Torres-Palomares, Rogelio Troyo-San Roman, Hernan Urbano, Nicolas Vacca, Daniel Vaimberg, María Lourdes Valencia Peña, Maria Lujan Vaselevich, Jaime Vazquez-Nares, Ezequiel Velez-Gomez, Laura N. Venegas-Godinez, Patricia Vercelli, Ricardo Verdugo, René Aloisio da Costa Vieira, Marta Vilensky, María José Villarubias, Manuel Isaac Villegas Gómez, Stella Viña, Silvia Vornetti, Anapaula Hidemi Uema Watanabe, Carlos Zamorano, Luis Zapata, and Zdenka Zlatar
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breast cancer ,Latin America ,PAM50 subtypes ,risk of recurrence ,biological pathways ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857).
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- 2022
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49. Active revegetation after mining: what is the contribution of peer-reviewed studies?
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Silvia E. Navarro-Ramos, Javier Sparacino, Juan M. Rodríguez, Edith Filippini, Benjamín E. Marsal-Castillo, Leandro García-Cannata, Daniel Renison, and Romina C. Torres
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Establishment ,Mine ,Planting ,Rehabilitation ,Sowing ,Treatments ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Knowing the state of the art on research related to post-mining active revegetation can help to improve revegetation success and identify research gaps. We performed a systematic review about active revegetation after mining and identified 203 relevant studies. Most studies were performed in the USA (34%), in regions with a temperate climate (59%) and in abandoned coal mines (45%). The studies were focused on the plantation of woody species (59%) or sowing of herbaceous species (39%). The most widely evaluated treatments were the addition of amendments (24%) and fertilizers (21%), mainly with positive and neutral effects; in general, organic amendments presented more positive effects than inorganic amendments and fertilizers. We also identified studies on the effects of plowing, inoculation of microorganisms, nurse plants, herbivore exclusion and watering. The results of these treatments should be taken with caution, because they can vary according to the functional strategies of the introduced species and the local context, such as the degree of nutrient limitation in the mining area and abiotic conditions. Further research is needed in non-temperate climates, involving long-term monitoring and with detailed descriptions of the interventions to better interpret results and general implications of active revegetation of mining areas.
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- 2022
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50. Exclusivity and comprehensiveness of Law. Some reflections on the open nature of legal systems
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Pablo E. Navarro
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lagunas del derecho ,discreción judicial ,sistema jurídico ,validez normativa ,aplicabilidad ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Abstract
This paper analyzes the possible meaning and plausibility of two well-known theses: exclusivity and comprehensiveness of law. According to the first, the positive norms exhaust the content of the law, while the second expresses that legal systems always provide an answer to justify a judicial decision. The theoretical framework chosen is the approach of contemporary legal positivism and, it is shown that, to a large extent, a positivistic interpretation of both above-mentioned theses depends on a distinction between the «global system», which is the set of norms valid at a certain moment T (i.e., the moment of the judicial decision that resolves a dispute) and the system of applicable norms. In turn, this distinction allows us to analyze the open nature of global systems from four different points of view: regulatory, logical, normative and interpretative. Finally, the consequences of these distinctions for the problem of judicial discretion are explored.
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- 2020
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