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13 results on '"Du, Yi-Nan"'

2. Inhibitory effect of sea cucumber coelomic fluid extracts on white shrimp autolysis

Author

NIE Bin, LI Ao-ting, CUI Xiao-fan, DU Yi-nan, YAN Jia-nan, and WU Hai-tao

Subjects
sea cucumber, coelomic fluid, extracts, white shrimp, autolysis, Food processing and manufacture, TP368-456
Abstract

Objective: In this paper, the inhibition of protein degradation in autolysis of white shrimp （Penaeus vannamei） surimi by extracts from the coelomic fluid of sea cucumber （Stichopus japonicus）, a by-product of sea cucumber processing, was studied. Methods: The protein degradation in autolysis of white shrimp was studied by SDS-PAGE assay. Furthermore, the effect of sea cucumber coelomic fluid and its extracts on white shrimp protein degradation was determined by SDS-PAGE and TCA-soluble oligopeptide assay. Results: The optimal conditions of white shrimp autolysis were incubation at pH 3.0, 50 ℃ for 2 h. The bond intensities of myosin heavy chain around （200 kDa） and actin around （44.3 kDa） decreased suggesting the protein degradation of white shrimp. The sea cucumber coelomic fluid showed inhibitory effect on protein degradation in autolysis of white shrimp. When the concentration of coelomic fluid extract of sea cucumber was in the range of 6.25%~25.00%, the protein degradation was significantly inhibited. The release of TCA-soluble oligopeptide was also significantly inhibited by coelomic fluid extract at 12.50%~25.00%. Conclusion: Sea cucumber coelomic fluid extracts possess inhibitory effect on protein degradation of white shrimp, indicating suppression of white shrimp surimi autolysis.

Published
2022
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4. A review on Zika vaccine development

Author

Peng, Zhe-Yu, primary, Yang, Song, additional, Lu, Hong-Zheng, additional, Wang, Lin-Min, additional, Li, Ni, additional, Zhang, Hai-Ting, additional, Xing, Si-Yu, additional, Du, Yi-Nan, additional, and Deng, Sheng-Qun, additional

Published
2024
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6. Sterility of Aedes albopictus by X-ray Irradiation as an Alternative to γ-ray Irradiation for the Sterile Insect Technique

Author

Wang, Lin-Min, primary, Li, Ni, additional, Ren, Cui-Ping, additional, Peng, Zhe-Yu, additional, Lu, Hong-Zheng, additional, Li, Dong, additional, Wu, Xin-Yu, additional, Zhou, Zi-Xin, additional, Deng, Jian-Yi, additional, Zheng, Zi-Han, additional, Wang, Ruo-Qing, additional, Du, Yi-Nan, additional, Wang, Duo-Quan, additional, and Deng, Sheng-Qun, additional

Published
2023
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12. Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

Author

Deng, Yue-Zhen, primary, Cai, Zhen, additional, Shi, Shuo, additional, Jiang, Hao, additional, Shang, Yu-Rong, additional, Ma, Ning, additional, Wang, Jing-Jing, additional, Guan, Dong-Xian, additional, Chen, Tian-Wei, additional, Rong, Ye-Fei, additional, Qian, Zhen-Yu, additional, Zhang, Er-Bin, additional, Feng, Dan, additional, Zhou, Quan-Li, additional, Du, Yi-Nan, additional, Liu, Dong-Ping, additional, Huang, Xing-Xu, additional, Liu, Lu-Ming, additional, Chin, Eugene, additional, Li, Dang-Sheng, additional, Wang, Xiao-Fan, additional, Zhang, Xue-Li, additional, and Xie, Dong, additional

Published
2017
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13. Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

Author

Deng, Yue-Zhen, Cai, Zhen, Shi, Shuo, Jiang, Hao, Shang, Yu-Rong, Ma, Ning, Wang, Jing-Jing, Guan, Dong-Xian, Chen, Tian-Wei, Rong, Ye-Fei, Qian, Zhen-Yu, Zhang, Er-Bin, Feng, Dan, Zhou, Quan-Li, Du, Yi-Nan, Liu, Dong-Ping, Huang, Xing-Xu, Liu, Lu-Ming, Chin, Eugene, Li, Dang-Sheng, Wang, Xiao-Fan, Zhang, Xue-Li, and Xie, Dong

Abstract

Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transformation of normal pancreatic cells (HPDE6C7) and NIH3T3 cells through activating the mevalonate (MVA) pathway. Disruption of ciliogenesis up-regulated MVA enzymes through β catenin–T cell factor (TCF) signaling, which synchronized with sterol regulatory element binding transcription factor 2 (SREBP2), and the regulation of MVA by β-catenin–TCF signaling was recapitulated in a mouse model of pancreatic ductal adenocarcinoma (PDAC) and human PDAC samples. Moreover, disruption of ciliogenesis by depleting Tg737 dramatically promoted tumorigenesis in the PDAC mouse model, driven by KrasG12D, which was inhibited by statin, an inhibitor of the MVA pathway. Collectively, this study emphasizes the crucial roles of cilia in governing the early steps of the transformation by activating the MVA pathway, suggesting that statin has therapeutic potential for pancreatic cancer treatment.

Published
2018
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