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22 results on '"Du, Jiale"'

5. Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex

Author

Horn-Ghetko, Daniel, primary, Hopf, Linus V. M., additional, Tripathi-Giesgen, Ishita, additional, Du, Jiale, additional, Kostrhon, Sebastian, additional, Vu, D. Tung, additional, Beier, Viola, additional, Steigenberger, Barbara, additional, Prabu, J. Rajan, additional, Stier, Luca, additional, Bruss, Elias M., additional, Mann, Matthias, additional, Xiong, Yue, additional, and Schulman, Brenda A., additional

Published
2024
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10. Electrical Degradation of In Situ SiN/AlGaN/GaN MIS-HEMTs Caused by Dehydrogenation and Trap Effect Under Hot Carrier Stress

Author

Meng Zhang, Xuerui Niu, Xiaohua Ma, Ting-Chang Chang, Fong-Min Ciou, Du Jiale, Bin Hou, Qing Zhu, Yilin Chen, Chong Wang, Yu-Shan Lin, Mei Wu, Kuan-Hsu Chen, Ling Yang, and Yue Hao

Subjects
Materials science, Condensed matter physics, Scattering, Transconductance, Transistor, Electron, Electronic, Optical and Magnetic Materials, law.invention, Stress (mechanics), Barrier layer, law, Dehydrogenation, Density functional theory, Electrical and Electronic Engineering
Abstract

The gate and drain bias dependence of hot electron-induced degradation in GaN-based metal–insulator–semiconductor high electron mobility transistors (MIS-HEMTs) was investigated in this work. Devices exhibit an abnormal increase in peak transconductance ( ${G}_{m}$ ,max) during hot carrier stress (HCS) and a partially quick recovery of that after removing the electrical stress. A physical model is proposed to explain the abnormal electrical characteristics caused by HCS. By using density functional theory (DFT), we calculated the energy for electrons to dehydrogenate preexisting [NGaH3]−1 complexes in GaN layer during stress. The dehydrogenation of defects affects the Gm,max of devices. Meanwhile, the neutralization of donor traps in AlGaN barrier layer also plays a significant role in the increase of Gm,max and the detrapping effect of electrons from these traps after removing the electrical stress accounts for the partially quick recovery of ${G}_{m, \text{max}}$ .

Published
2021

11. Ubiquitination drives COPI priming and Golgi SNARE localization

Author

Date, Swapneeta S, primary, Xu, Peng, additional, Hepowit, Nathaniel L, additional, Diab, Nicholas S, additional, Best, Jordan, additional, Xie, Boyang, additional, Du, Jiale, additional, Strieter, Eric R, additional, Jackson, Lauren P, additional, MacGurn, Jason A, additional, and Graham, Todd R, additional

Published
2022
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15. Analytical Model on the Threshold Voltage of p-Channel Heterostructure Field-Effect Transistors on a GaN-Based Complementary Circuit Platform

Author

Niu, Xuerui, primary, Hou, Bin, additional, Yang, Ling, additional, Zhang, Meng, additional, Zhang, Xinchuang, additional, Lu, Hao, additional, Jia, Fuchun, additional, Du, Jiale, additional, Wu, Mei, additional, Song, Fang, additional, Wang, Chong, additional, Ma, Xiaohua, additional, and Hao, Yue, additional

Published
2022
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16. Electrical Degradation of In Situ SiN/AlGaN/GaN MIS-HEMTs Caused by Dehydrogenation and Trap Effect Under Hot Carrier Stress

Author

Niu, Xuerui, primary, Ma, Xiaohua, additional, Hou, Bin, additional, Yang, Ling, additional, Lin, Yu-Shan, additional, Zhu, Qing, additional, Ciou, Fong-Min, additional, Chen, Kuan-Hsu, additional, Chen, Yilin, additional, Du, Jiale, additional, Wu, Mei, additional, Zhang, Meng, additional, Wang, Chong, additional, Chang, Ting-Chang, additional, and Hao, Yue, additional

Published
2021
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21. A Novel TCN-LSTM Hybrid Model for sEMG-Based Continuous Estimation of Wrist Joint Angles.

Author

Du J, Liu Z, Dong W, Zhang W, and Miao Z

Subjects
Humans, Range of Motion, Articular physiology, Movement physiology, Signal Processing, Computer-Assisted, Algorithms, Adult, Male, Wrist physiology, Electromyography methods, Wrist Joint physiology, Neural Networks, Computer
Abstract

Surface electromyography (sEMG) offers a novel method in human-machine interactions (HMIs) since it is a distinct physiological electrical signal that conceals human movement intention and muscle information. Unfortunately, the nonlinear and non-smooth features of sEMG signals often make joint angle estimation difficult. This paper proposes a joint angle prediction model for the continuous estimation of wrist motion angle changes based on sEMG signals. The proposed model combines a temporal convolutional network (TCN) with a long short-term memory (LSTM) network, where the TCN can sense local information and mine the deeper information of the sEMG signals, while LSTM, with its excellent temporal memory capability, can make up for the lack of the ability of the TCN to capture the long-term dependence of the sEMG signals, resulting in a better prediction. We validated the proposed method in the publicly available Ninapro DB1 dataset by selecting the first eight subjects and picking three types of wrist-dependent movements: wrist flexion (WF), wrist ulnar deviation (WUD), and wrist extension and closed hand (WECH). Finally, the proposed TCN-LSTM model was compared with the TCN and LSTM models. The proposed TCN-LSTM outperformed the TCN and LSTM models in terms of the root mean square error ( RMSE ) and average coefficient of determination ( R 2 ). The TCN-LSTM model achieved an average RMSE of 0.064, representing a 41% reduction compared to the TCN model and a 52% reduction compared to the LSTM model. The TCN-LSTM also achieved an average R 2 of 0.93, indicating an 11% improvement over the TCN model and an 18% improvement over the LSTM model.

Published
2024
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22. Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.

Author

Adolf F, Du J, Goodall EA, Walsh RM Jr, Rawson S, von Gronau S, Harper JW, Hanna J, and Schulman BA

Abstract

Dedicated assembly factors orchestrate stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here, we report cryo-EM reconstructions of seven recombinant human subcomplexes that visualize all five chaperones and the three active site propeptides across a wide swath of the assembly pathway. Comparison of these chaperone-bound intermediates and a matching mature CP reveals molecular mechanisms determining the order of successive subunit additions, and how proteasome subcomplexes and assembly factors structurally adapt upon progressive subunit incorporation to stabilize intermediates, facilitate the formation of subsequent intermediates, and ultimately rearrange to coordinate proteolytic activation with gated access to active sites. The structural findings reported here explain many previous biochemical and genetic observations. This work establishes a methodologic approach for structural analysis of multiprotein complex assembly intermediates, illuminates specific functions of assembly factors, and reveals conceptual principles underlying human proteasome biogenesis., Competing Interests: Competing Interest Statement J.W.H. is a founder and consultant for Caraway Therapeutics. B.A.S. is on the scientific advisory boards of Biotheryx and Proxygen. All other authors have no competing interests to declare.

Published
2024
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