Search

Your search keyword '"Dotsev, A. V."' showing total 133 results
Start Over Author "Dotsev, A. V." Search Limiters Available in Library Collection
133 results on '"Dotsev, A. V."'

1. Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds

Author

Romanov, Michael N., Abdelmanova, Alexandra S., Fisinin, Vladimir I., Gladyr, Elena A., Volkova, Natalia A., Koshkina, Olga A., Rodionov, Andrey N., Vetokh, Anastasia N., Gusev, Igor V., Anshakov, Dmitry V., Stanishevskaya, Olga I., Dotsev, Arsen V., Griffin, Darren K., and Zinovieva, Natalia A.

Published
2023
Full Text
View/download PDF

2. Genetic Diversity in the Orenburg Goat Breed Revealed by Single-Nucleotide Polymorphism (SNP) Analysis: Initial Steps in Saving a Threatened Population.

Author

Deniskova, Tatiana E., Dotsev, Arsen V., Abdelmanova, Alexandra S., Petrov, Sergey N., Frolov, Alexey N., Platonov, Stanislav A., Gladyr, Elena A., Gusev, Igor V., Selionova, Marina I., Rodionov, Andrey N., Lebedev, Svyatoslav V., Griffin, Darren K., Romanov, Michael N., and Zinovieva, Natalia A.

Subjects
*SINGLE nucleotide polymorphisms, *GENETIC variation, *LIVESTOCK breeds, *OUTCROSSING (Biology), *ANIMAL breeders, *GOAT breeds
Abstract

Background/Objectives: Orenburg goats are renowned for their soft down that acts as a substrate for warm clothing, particularly shawls that have an international reputation. As with many local livestock breeds, however, the Orenburg is presently at risk of extinction, an issue that can be addressed by assessing population genetic diversity and, thereafter, encouraging as much outbreeding as possible. Using single-nucleotide polymorphism (SNP)-based data, therefore, we analyzed the genetic diversity and population structure of modern Orenburg goats using samples collected from an expedition to Orenburg Oblast in 2024. Methods: We applied the Goat SNP50 BeadChip (Illumina, San Diego, CA, USA) for the genotyping of Orenburg goats from modern and archived populations. SNP genotypes of three Orenburg populations sampled in 2017 and 2019, Altai Mountain, Altai White, and Soviet Mohair breeds, were added to the dataset. Results: Principal component analysis and network and admixture analyses demonstrated that the genetic background inherent to the archived group of Orenburg goats was maintained in all modern populations. Values of genetic diversity indicators in modern populations were compatible with those obtained in comparison groups. Runs of homozygosity (ROH) were found in all the Orenburg goat populations (with a mean ROH length of 72.6–108.9 Mb and mean ROH number of 28–36). Genomic inbreeding based on ROH was low in all the Orenburg populations (FROH = 0.03–0.045). Conclusions: We showed that the ancestral background is retained in present-day Orenburg goats sampled in 2024. We provide the genetic basis through which certain breeder animals may be selected and bred traditionally or ex situ through a conservation program of gamete preservation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Dissecting selective signatures and candidate genes in grandparent lines subject to high selection pressure for broiler production and in a local Russian chicken breed of Ushanka

Author

Romanov, Michael N., Shakhin, Alexey V., Abdelmanova, Alexandra S., Volkova, Natalia A., Efimov, Dmitry N., Fisinin, Vladimir I., Korshunova, Liudmila G., Anshakov, Dmitry V., Dotsev, Arsen V., Griffin, Darren K., Zinovieva, Natalia A., Romanov, Michael N., Shakhin, Alexey V., Abdelmanova, Alexandra S., Volkova, Natalia A., Efimov, Dmitry N., Fisinin, Vladimir I., Korshunova, Liudmila G., Anshakov, Dmitry V., Dotsev, Arsen V., Griffin, Darren K., and Zinovieva, Natalia A.

Abstract

Breeding improvements and quantitative trait genetics are essential to the advancement of broiler production. The impact of artificial selection on genomic architecture and the genetic markers sought remains a key area of research. Here, we used whole-genome resequencing data to analyze the genomic architecture, diversity, and selective sweeps in Cornish White (CRW) and Plymouth Rock White (PRW) transboundary breeds selected for meat production and, comparatively, in an aboriginal Russian breed of Ushanka (USH). Reads were aligned to the reference genome bGalGal1.mat.broiler.GRCg7b and filtered to remove PCR duplicates and low-quality reads using BWA-MEM2 and bcftools software; 12,563,892 SNPs were produced for subsequent analyses. Compared to CRW and PRW, USH had a lower diversity and a higher genetic distinctiveness. Selective sweep regions and corresponding candidate genes were examined based on ZFST, hapFLK, and ROH assessment procedures. Twenty-seven prioritized chicken genes and the functional projection from human homologs suggest their importance for selection signals in the studied breeds. These genes have a functional relationship with such trait categories as body weight, muscles, fat metabolism and deposition, reproduction, etc., mainly aligned with the QTLs in the sweep regions. This information is pivotal for further executing genomic selection to enhance phenotypic traits.

Published
2024

6. Whole genome screening procures a holistic hold of the Russian chicken gene pool heritage and demographic history

Author

Romanov, Michael N., Abdelmanova, Alexandra S., Fisinin, Vladimir I., Gladyr, Elena A., Volkova, Natalia A., Anshakov, Dmitry V., Stanishevskaya, Olga I., Vakhrameev, Anatoly B., Dotsev, Arsen V., Griffin, Darren K., Zinovieva, Natalia A., Romanov, Michael N., Abdelmanova, Alexandra S., Fisinin, Vladimir I., Gladyr, Elena A., Volkova, Natalia A., Anshakov, Dmitry V., Stanishevskaya, Olga I., Vakhrameev, Anatoly B., Dotsev, Arsen V., Griffin, Darren K., and Zinovieva, Natalia A.

Abstract

Simple Summary: A collection of native farm animal breeds can be considered as a gene pool and a national heritage. Long-term artificial selection in domesticated animals has certain effects on their genomes, which can be investigated using genome-wide screens for DNA sequence variation, that is, so-called single nucleotide polymorphism (SNP) screens. Here, we looked at the genomes of 19 Russian chicken gene pool breeds, both native and imported, evaluating the contrasting egg, meat and dual-purpose types. Based on genetic diversity statistics, we identified differences between the breeds using many DNA markers (SNPs) that may represent genomic regions that are being selected for, either within a specific breed or shared between breeds. Our research will be helpful for further understanding the genomic diversity and demographic history of Russian domestic chickens. This would be essential for their successful breeding. Abstract: A study for genomic variation that may reflect putative selective signaling and be associated with economically important traits is instrumental for obtaining information about demographic and selection history in domestic animal species and populations. A rich variety of the Russian chicken gene pool breeds warrants a further detailed study. Specifically, their genomic features can derive implications from their genome architecture and selective footprints for their subsequent breeding and practical efficient exploitation. In the present work, whole genome genotyping of 19 chicken breeds (20 populations with up to 71 samples each) was performed using the Chicken 50 K BeadChip DNA chip. The studied breed sample included six native Russian breeds of chickens developed in the 17th–19th centuries, as well as eight Russian chicken breeds, including the Russian White (RW), created in the 20th century on the basis of improving local chickens using breeds of foreign selection. Five specialized foreign breeds of chickens, including the White Leghorn

Published
2023

18. PSXVI-17 Estimation of inbreeding in local sheep breeds of west Asian and central Asian origin based on high-density SNP-genotypes

Author

Deniskova, Tatiana E, primary, Abdelmanova, Alexandra S, additional, Dotsev, Arsen V, additional, Lushihina, Eugenia, additional, Zhunushev, Asankadyr, additional, Reyer, Henry, additional, Selionova, Marina I, additional, Wimmers, Klaus, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A, additional

Published
2021
Full Text
View/download PDF

21. Unveiling Comparative Genomic Trajectories of Selection and Key Candidate Genes in Egg-Type Russian White and Meat-Type White Cornish Chickens

Author

Abdelmanova, Alexandra S., primary, Dotsev, Arsen V., additional, Romanov, Michael N., additional, Stanishevskaya, Olga I., additional, Gladyr, Elena A., additional, Rodionov, Andrey N., additional, Vetokh, Anastasia N., additional, Volkova, Natalia A., additional, Fedorova, Elena S., additional, Gusev, Igor V., additional, Griffin, Darren K., additional, Brem, Gottfried, additional, and Zinovieva, Natalia A., additional

Published
2021
Full Text
View/download PDF

22. Comparative Study of the Genetic Diversity of Local Steppe Cattle Breeds from Russia, Kazakhstan and Kyrgyzstan by Microsatellite Analysis of Museum and Modern Samples

Author

Abdelmanova, Alexandra S., primary, Kharzinova, Veronika R., additional, Volkova, Valeria V., additional, Dotsev, Arsen V., additional, Sermyagin, Alexander A., additional, Boronetskaya, Oksana I., additional, Chinarov, Roman Yu., additional, Lutshikhina, Evgeniya M., additional, Sölkner, Johann, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A., additional

Published
2021
Full Text
View/download PDF

25. Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep

Author

Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, James, Li, Meng-Hua, Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, James, and Li, Meng-Hua

Abstract

How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here we conducted a comprehensive genomic analysis of diversity, interspecies introgression and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600k and 50k genome-wide SNP data from 3447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248302667-248306614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication.

Published
2021

26. Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep

Author

One Health Toxicologie, Afd Pharmacology, Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, James, Li, Meng-Hua, One Health Toxicologie, Afd Pharmacology, Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, James, and Li, Meng-Hua

Published
2021

27. Unveiling comparative genomic trajectories of selection and key candidate genes in egg-type Russian White and meat-type White Cornish chickens

Author

Abdelmanova, Alexandra S., Dotsev, Arsen V., Romanov, Michael N., Stanishevskaya, Olga I., Gladyr, Elena A., Rodionov, Andrey N., Vetokh, Anastasia N., Volkova, Natalia A., Fedorova, Elena S., Gusev, Igor V., Griffin, Darren K., Brem, Gottfried, Zinovieva, Natalia A., Abdelmanova, Alexandra S., Dotsev, Arsen V., Romanov, Michael N., Stanishevskaya, Olga I., Gladyr, Elena A., Rodionov, Andrey N., Vetokh, Anastasia N., Volkova, Natalia A., Fedorova, Elena S., Gusev, Igor V., Griffin, Darren K., Brem, Gottfried, and Zinovieva, Natalia A.

Abstract

Simple Summary: The search for genomic regions of putative selective signaling is instrumental in obtaining information about selection history in various species and populations. Domestic animals are subject to long-term artificial selection that leaves certain footprints in their genomes one can explore using genome-wide SNP screen. We examined here genomes of two contrasting chicken breeds, the native egg-type Russian White and meat-type White Cornish. Using three statistics, we identified genomic regions under putative selection, both breed-specific and shared between two breeds, that harbor key candidate genes for economically important traits. Our findings will be useful in further understanding selection history and genomic diversity in domestic chickens that would be pivotal in their productive breeding. Abstract: Comparison of genomic footprints in chicken breeds with different selection history is a powerful tool in elucidating genomic regions that have been targeted by recent and more ancient selection. In the present work, we aimed at examining and comparing the trajectories of artificial selection in the genomes of the native egg-type Russian White (RW) and meat-type White Cornish (WC) breeds. Combining three different statistics (top 0.1% SNP by FST value at pairwise breed comparison, hapFLK analysis, and identification of ROH island shared by more than 50% of individuals), we detected 45 genomic regions under putative selection including 11 selective sweep regions, which were detected by at least two different methods. Four of such regions were breed-specific for each of RW breed (on GGA1, GGA5, GGA8, and GGA9) and WC breed (on GGA1, GGA5, GGA8, and GGA28), while three remaining regions on GGA2 (two sweeps) and GGA3 were common for both breeds. Most of identified genomic regions overlapped with known QTLs and/or candidate genes including those for body temperatures, egg productivity, and feed intake in RW chickens and those for growth, meat and carcas

Published
2021

28. Mitochondrial DNA Analysis Clarifies Taxonomic Status of the Northernmost Snow Sheep (Ovis nivicola) Population

Author

Dotsev, Arsen V., primary, Kunz, Elisabeth, additional, Kharzinova, Veronika R., additional, Okhlopkov, Innokentiy M., additional, Lv, Feng-Hua, additional, Li, Meng-Hua, additional, Rodionov, Andrey N., additional, Shakhin, Alexey V., additional, Sipko, Taras P., additional, Medvedev, Dmitry G., additional, Gladyr, Elena A., additional, Bagirov, Vugar A., additional, Brem, Gottfried, additional, Medugorac, Ivica, additional, and Zinovieva, Natalia A., additional

Published
2021
Full Text
View/download PDF

29. Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds †.

Author

Abdelmanova, Alexandra S., Sermyagin, Alexander A., Dotsev, Arsen V., Bardukov, Nikolay V., Fornara, Margaret S., Brem, Gottfried, and Zinovieva, Natalia A.

Subjects
CATTLE breeds, CATTLE breeding, STATURE, SINGLE nucleotide polymorphisms, SCIENCE education, GENOME-wide association studies
Abstract

Cattle breeds used in industrial production tend to have a larger size compared to the local cattle, as the increased dairy and beef productivity is closely related to the stature. The aim of our work was to identify single nucleotide polymorphisms (SNPs), which are significantly associated with stature in diverse cattle breeds. Thirteen local and transboundary cattle breeds (n = 670) subjected to our study were divided in two groups according to the stature. The high-stature group included Angus, Ayrshire, Black-and-White, Holstein, Kholmogor, Yaroslavl, Tagil and Istoben breeds. The low-stature group comprised of Jersey, Kalmyk, Kyrgyz, Mongolian and Yakut cattle. The average height at withers was 136.3 ± 1.6 and 121.6 ± 2.8 cm in the high- and low-stature groups, respectively. The samples of 11 breeds were genotyped using high-density DNA arrays (Illumina Inc., USA). The genotypes of two remaining breeds were downloaded from the publicly available WIDDE database. Genome-wide association studies revealed four SNPs, which were strongly associated with the stature, including three SNPs at 77.3–77.8 cM on BTA4 (map53144-ss46525999, p < 7.747 × 10−101; BovineHD0400021479, p < 1.173 × 10−91; ARS-BFGL-NGS-116590, p < 7.665 × 10−105) and one SNPs at 25.2 cM on BTA14 (BovineHD1400007259, p < 1.324 × 10−109). Functional annotation showed the localization within identified regions of genes, which are responsible for growth, exterior characteristics, protein and lipid metabolism, and feed intake. Identified SNPs can be considered as useful DNA markers for marker-assistant cattle breeding aimed at increased stature. The study was funded by the Russian Ministry of Science and Higher Education No. 0445-2019-0024. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

33. PSIII-15 Genetic variability of Russian domestic reindeer populations (Rangifer Tarandus) by microsatellites

Author

Kharzinova, Veronika R, primary, Dotsev, Arsen V, additional, Solovieva, Anastasiya D, additional, Fedorov, Valeriy I, additional, Shimit, Larisa D, additional, Romanenko, Tatiana M, additional, Senchik, Alexander V, additional, Sergeeva, Olga K, additional, Goncharov, Vasily V, additional, Layshev, Kasim A, additional, Yuzhakov, Alexander A, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A, additional

Published
2020
Full Text
View/download PDF

35. PSXII-32 Testing of low-density SNP panel in wild and domestic reindeer populations (Rangifer tarandus)

Author

Deniskova, Tatiana Evgenievna, primary, Kharzinova, Veronika R, additional, Dotsev, Arsen V, additional, Solovieva, Anastasiya D, additional, Layshev, Kasim A, additional, Yuzhakov, Alexander A, additional, Romanenko, Tatiana M, additional, Fedorov, Valeriy I, additional, Reyer, Henry, additional, Wimmers, Klaus, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A, additional

Published
2020
Full Text
View/download PDF

37. PSIII-13 Genetic assessment of isolated reindeer (Rangifer Tarandus) population from Tuva, Russia

Author

Dotsev, Arsen V, primary, Kharzinova, Veronika R, additional, Shimit, Larisa D, additional, Sergeeva, Olga K, additional, Goncharov, Vasily V, additional, Layshev, Kasim A, additional, Romanenko, Tatiana M, additional, Fedorov, Valeriy I, additional, Senchik, Alexander V, additional, Okhlopkov, Innokentiy M, additional, Medvedev, Dmitry G, additional, Reyer, Henry, additional, Wimmers, Klaus, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A, additional

Published
2020
Full Text
View/download PDF

39. Historical Introgression from Wild Relatives Enhanced Climatic Adaptation and Resistance to Pneumonia in Sheep

Author

Cao, Yin-Hong, primary, Xu, Song-Song, additional, Shen, Min, additional, Chen, Ze-Hui, additional, Gao, Lei, additional, Lv, Feng-Hua, additional, Xie, Xing-Long, additional, Wang, Xin-Hua, additional, Yang, Hua, additional, Liu, Chang-Bin, additional, Zhou, Ping, additional, Wan, Peng-Cheng, additional, Zhang, Yun-Sheng, additional, Yang, Jing-Quan, additional, Pi, Wen-Hui, additional, Hehua, EEr, additional, Berry, Donagh P, additional, Barbato, Mario, additional, Esmailizadeh, Ali, additional, Nosrati, Maryam, additional, Salehian-Dehkordi, Hosein, additional, Dehghani-Qanatqestani, Mostafa, additional, Dotsev, Arsen V, additional, Deniskova, Tatiana E, additional, Zinovieva, Natalia A, additional, Brem, Gottfried, additional, Štěpánek, Ondřej, additional, Ciani, Elena, additional, Weimann, Christina, additional, Erhardt, Georg, additional, Mwacharo, Joram M, additional, Ahbara, Abulgasim, additional, Han, Jian-Lin, additional, Hanotte, Olivier, additional, Miller, Joshua M, additional, Sim, Zijian, additional, Coltman, David, additional, Kantanen, Juha, additional, Bruford, Michael W, additional, Lenstra, Johannes A, additional, Kijas, James, additional, and Li, Meng-Hua, additional

Published
2020
Full Text
View/download PDF

40. Genetic Diversity of Historical and Modern Populations of Russian Cattle Breeds Revealed by Microsatellite Analysis

Author

Abdelmanova, Alexandra S., primary, Kharzinova, Veronika R., additional, Volkova, Valeria V., additional, Mishina, Arina I., additional, Dotsev, Arsen V., additional, Sermyagin, Alexander A., additional, Boronetskaya, Oxana I., additional, Petrikeeva, Lidia V., additional, Chinarov, Roman Yu, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A., additional

Published
2020
Full Text
View/download PDF

41. Complete mitochondrial genomes of Karchaev goat (Capra hircus)

Author

Rodionov, Andrey N., primary, Dotsev, Arsen V., additional, Fomenko, Oleg Y., additional, Bakoev, Neckruz F., additional, Deniskova, Tatiana E., additional, Shakhin, Alexey V., additional, Bagirov, Vugar A., additional, Kunz, Elisabeth, additional, Medugorac, Ivica, additional, Krebs, Stefan, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A., additional

Published
2020
Full Text
View/download PDF

42. High-density genotyping reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia

Author

Yurchenko, A A, Deniskova, T E, Yudin, N S, Dotsev, A V, Khamiruev, T N, Selionova, M I, Egorov, S V, Reyer, H, Wimmers, K, Brem, G, Zinovieva, N A, and Larkin, D M

Abstract

Domestication and centuries of selective breeding have changed genomes of sheep breeds to respond to environmental challenges and human needs. The genomes of local breeds, therefore, are valuable sources of genomic variants to be used to understand mechanisms of response to adaptation and artificial selection. As a step toward this we performed a high-density genotyping and comprehensive scans for signatures of selection in the genomes from 15 local sheep breeds reared across Russia.

Published
2019

43. Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep

Author

Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, Jame, Li, Meng-Hua, Barbato, Mario (ORCID:0000-0002-7203-1549), Cao, Yin-Hong, Xu, Song-Song, Shen, Min, Chen, Ze-Hui, Gao, Lei, Lv, Feng-Hua, Xie, Xing-Long, Wang, Xin-Hua, Yang, Hua, Liu, Chang-Bin, Zhou, Ping, Wan, Peng-Cheng, Zhang, Yun-Sheng, Yang, Jing-Quan, Pi, Wen-Hui, EEr, Hehua, Berry, Donagh P, Barbato, Mario, Esmailizadeh, Ali, Nosrati, Maryam, Salehian-Dehkordi, Hosein, Dehghani-Qanatqestani, Mostafa, Dotsev, Arsen V, Deniskova, Tatiana E, Zinovieva, Natalia A, Brem, Gottfried, Štěpánek, Ondřej, Ciani, Elena, Weimann, Christina, Erhardt, Georg, Mwacharo, Joram M, Ahbara, Abulgasim, Han, Jian-Lin, Hanotte, Olivier, Miller, Joshua M, Sim, Zijian, Coltman, David, Kantanen, Juha, Bruford, Michael W, Lenstra, Johannes A, Kijas, Jame, Li, Meng-Hua, and Barbato, Mario (ORCID:0000-0002-7203-1549)

Abstract

How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here we conducted a comprehensive genomic analysis of diversity, interspecies introgression and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600k and 50k genome-wide SNP data from 3447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248302667-248306614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication.

Published
2020

44. Characteristics of the Allele Pool and the Genetic Differentiation of Goats of Different Breeds and their Wild Relatives by Str-Markers.

Author

Selionova, M. I., M Aibazov, A.-M., Mamontova, T. V., Stolpovsky, A, Beketov, S. V., Petrov, S. N., Kharzinova, V. R., Dotsev, A. V., and Zinovieva, N. A.

Subjects
GOAT breeds, GOATS, ALLELES, GENETIC variation, CLUSTER analysis (Statistics), CATTLE genetics
Abstract

Based on 16 STR-loci, the allele pool and interbreed differentiation of goat breeds of Russian and foreign breeding were investigated in this study. These breeds included Karachai (KRCH-K, n=73, mountain zone; KRCH-Z, n=33, foothill zone), Dagestan Downy (DAGD, n=30), Dagestan Wool (DAGW, n=30), Soviet Wool (SOVW, n=30), Saanen (SAAN, n=34), Murciano-Granadina (MURS, n=37), as well as wild goats, represented by three species of mountain goats (n=52): Siberian Capricorn (Capra sibirica) of Altai (CSIB-S, n=6), Tajikistan (CSIB-T, n=4), Kyrgyzstan (CSIB-K, n=6), and the Himalayas (CSIB-H, n=4); Bezoar goat (Capa aegagrus) of Turkey (CAEG, n=3) and Pakistan (CAEG-S, n=3); West Caucasian tur (Capra caucasica): western Caucasian (Kuban, CCAU-K, n=10), central Caucasian (CCAU-M, n=8), and eastern Caucasian (Dagestan, CCAU-D, n=8). The highest genetic diversity was observed in the North Caucasus breeds, such as Karachai, Dagestan Downy, and Dagestan Wool. The mean numbers of alleles per locus and allelic diversity were 7.385-9.154 and 7.353-7.713, respectively. The genetic proximity of Caucasian breeds was confirmed by cluster analysis, and they formed a common branch with the highest genetic affinity, while the Orenburg and Soviet Wool breeds formed another branch, and the third branch with the least affinity was the dairy breed of foreign selection. The analysis of the phylogenetic tree of domestic and wild species established the formation of three clusters formed by the subspecies of the West Caucasian tur, Siberian ibex, and breeds of domestic goats. At the same time, populations of the Bezoar goats were localized at the root of the last cluster, which confirmed their role as the ancestors of domestic goats. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

48. The first complete mitochondrial genomes of snow sheep (Ovis nivicola) and thinhorn sheep (Ovis dalli) and their phylogenetic implications for the genus Ovis

Author

Dotsev, A. V., primary, Kunz, E., additional, Shakhin, A. V., additional, Petrov, S. N., additional, Kostyunina, O. V., additional, Okhlopkov, I. M., additional, Deniskova, T. E., additional, Barbato, M., additional, Bagirov, V. A., additional, Medvedev, D. G., additional, Krebs, S., additional, Brem, G., additional, Medugorac, I., additional, and Zinovieva, N. A., additional

Published
2019
Full Text
View/download PDF

50. Genome‐wideSNPanalysis unveils genetic structure and phylogeographic history of snow sheep (Ovis nivicola) populations inhabiting the Verkhoyansk Mountains and Momsky Ridge (northeastern Siberia)

Author

Dotsev, Arsen V., primary, Deniskova, Tatiana E., additional, Okhlopkov, Innokentiy M., additional, Mészáros, Gabor, additional, Sölkner, Johann, additional, Reyer, Henry, additional, Wimmers, Klaus, additional, Brem, Gottfried, additional, and Zinovieva, Natalia A., additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results