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1. Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

Author

Chuang, Shu-Chun, Boeing, Heiner, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Bueno-de-Mesquita, Bas, Lajous, Martin, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Küehn, Tilman, Pischon, Tobias, Drogan, Dagmar, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Agudo, Antonio, Molina-Montes, Esther, Dorronsoro, Miren, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H, Weiderpass, Elisabete, Palmqvist, Richard, Ljuslinder, Ingrid, Gunter, Marc, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, Vineis, Paolo, and Aleksandrova, Krasimira

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Cardiovascular, Nutrition, Aging, Clinical Research, Cell-mediated immunity, Metabolic syndrome, Neopterin, Clinical Sciences, Immunology, Clinical sciences
Abstract

BackgroundIncreased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).ResultsHigher total neopterin concentrations were associated with reduced HDLC (9.7 %, p

Published
2016

2. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

Author

Figueroa, Jonine D, Middlebrooks, Candace D, Banday, A Rouf, Ye, Yuanqing, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Koutros, Stella, Kiemeney, Lambertus A, Rafnar, Thorunn, Bishop, Timothy, Furberg, Helena, Matullo, Giuseppe, Golka, Klaus, Gago-Dominguez, Manuela, Taylor, Jack A, Fletcher, Tony, Siddiq, Afshan, Cortessis, Victoria K, Kooperberg, Charles, Cussenot, Olivier, Benhamou, Simone, Prescott, Jennifer, Porru, Stefano, Dinney, Colin P, Malats, Núria, Baris, Dalsu, Purdue, Mark P, Jacobs, Eric J, Albanes, Demetrius, Wang, Zhaoming, Chung, Charles C, Vermeulen, Sita H, Aben, Katja K, Galesloot, Tessel E, Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Kari, Kiltie, Anne E, Harland, Mark, Teo, Mark, Offit, Kenneth, Vijai, Joseph, Bajorin, Dean, Kopp, Ryan, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Selinski, Silvia, Hengstler, Jan G, Gerullis, Holger, Ovsiannikov, Daniel, Blaszkewicz, Meinolf, Castelao, Jose Esteban, Calaza, Manuel, Martinez, Maria Elena, Cordeiro, Patricia, Xu, Zongli, Panduri, Vijayalakshmi, Kumar, Rajiv, Gurzau, Eugene, Koppova, Kvetoslava, Bueno-De-Mesquita, H Bas, Ljungberg, Börje, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Krogh, Vittorio, Dorronsoro, Miren, Travis, Ruth C, Tjønneland, Anne, Brennan, Paul, Chang-Claude, Jenny, Riboli, Elio, Conti, David, Stern, Marianna C, Pike, Malcolm C, Van Den Berg, David, Yuan, Jian-Min, Hohensee, Chancellor, Jeppson, Rebecca P, Cancel-Tassin, Geraldine, Roupret, Morgan, Comperat, Eva, Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J, Kraft, Peter, Lindstrom, Sara, Carta, Angela, Pavanello, Sofia, Arici, Cecilia, Mastrangelo, Giuseppe, Kamat, Ashish M, Zhang, Liren, Gong, Yilei, Pu, Xia, Hutchinson, Amy, Burdett, Laurie, Wheeler, William A, and Karagas, Margaret R

Subjects
Cancer, Prevention, Human Genome, Genetics, Biotechnology, Urologic Diseases, Aetiology, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Case-Control Studies, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 20, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide, Risk Factors, Urinary Bladder Neoplasms, White People, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 × 10(-6)), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 × 10(-11)) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 × 10(-10)). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region-the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r(2) = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case-case P ≤ 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer.

Published
2016

3. Body iron status and gastric cancer risk in the EURGAST study

Author

Fonseca-Nunes, Ana, Agudo, Antonio, Aranda, Núria, Arija, Victoria, Cross, Amanda J, Molina, Esther, Sanchez, Maria Jose, Bueno-de-Mesquita, HB As, Siersema, Peter, Weiderpass, Elisabete, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Saieva, Calogero, Naccarati, Alessio, Ohlsson, Bodil, Sjöberg, Klas, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Fagherazzi, Guy, Boeing, Heiner, Steffen, Annika, Kühn, Tilman, Katzke, Verena, Tjønneland, Anne, Olsen, Anja, Khaw, Kay-Tee, Wareham, Nick, Key, Tim, Lu, Yunxia, Riboli, Elio, Peeters, Petra H, Gavrila, Diana, Dorronsoro, Miren, Quirós, José Ramón, Barricarte, Aurelio, Jenab, Mazda, Zamora-Ros, Raúl, Freisling, Heinz, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, and Jakszyn, Paula

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Oncology and Carcinogenesis, Clinical Research, Digestive Diseases, Nutrition, Rare Diseases, Prevention, Cancer, 2.1 Biological and endogenous factors, Aetiology, Adenocarcinoma, Case-Control Studies, Ferritins, Humans, Iron, Risk Factors, Stomach Neoplasms, gastric cancer, iron homeostasis, nested case-control study, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2  = 0.80, 95% CI = 0.72-0.88; OR10%increment  = 0.87, 95% CI = 0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl  = 1.13, 95% CI = 1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.

Published
2015

4. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author

Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-de-Mesquita, HB As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quirós, J Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay-Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Hepatitis, Infectious Diseases, Hepatitis - B, Liver Cancer, Prevention, Liver Disease, Cancer, Chronic Liver Disease and Cirrhosis, Rare Diseases, Nutrition, Digestive Diseases, Clinical Research, Emerging Infectious Diseases, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Adult, Aged, Carcinoma, Hepatocellular, Case-Control Studies, Diet, Dietary Fats, Europe, Feeding Behavior, Female, Humans, Incidence, Life Style, Liver Neoplasms, Male, Middle Aged, Nutritional Status, Prospective Studies, Risk, Risk Factors, Surveys and Questionnaires, Young Adult, European populations, cohort study, dietary fats, hepatocellular carcinoma, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.

Published
2015

5. Autoimmunity plays a role in the onset of diabetes after 40 years of age

Author

Rolandsson, Olov, Hampe, Christiane S., Sharp, Stephen J., Ardanaz, Eva, Boeing, Heiner, Fagherazzi, Guy, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Gunter, Marc J., Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Krogh, Vittorio, Kühn, Tilman, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Sánchez, Maria-José, Severi, Gianluca, Spijkerman, Annemieke M. W., Tumino, Rosario, van der Schouw, Yvonne T., Riboli, Elio, Forouhi, Nita G., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2020
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6. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

Author

Steffen, Annika, Huerta, José-Maria, Weiderpass, Elisabete, Bueno-de-Mesquita, HB As, May, Anne M, Siersema, Peter D, Kaaks, Rudolf, Neamat-Allah, Jasmine, Pala, Valeria, Panico, Salvatore, Saieva, Calogero, Tumino, Rosario, Naccarati, Alessio, Dorronsoro, Miren, Sánchez-Cantalejo, Emilio, Ardanaz, Eva, Quirós, J Ramón, Ohlsson, Bodil, Johansson, Mattias, Wallner, Bengt, Overvad, Kim, Halkjaer, Jytte, Tjønneland, Anne, Fagherazzi, Guy, Racine, Antoine, Clavel-Chapelon, Françoise, Key, Tim J, Khaw, Kay-Tee, Wareham, Nick, Lagiou, Pagona, Bamia, Christina, Trichopoulou, Antonia, Ferrari, Pietro, Freisling, Heinz, Lu, Yunxia, Riboli, Elio, Cross, Amanda J, Gonzalez, Carlos A, and Boeing, Heiner

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Rare Diseases, Digestive Diseases, Cancer, Obesity, Nutrition, Adenocarcinoma, Adult, Aged, Body Mass Index, Body Weights and Measures, Esophageal Neoplasms, Europe, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Abdominal, Population Surveillance, Prospective Studies, Risk, Risk Factors, Stomach Neoplasms, abdominal obesity, body mass index, esophageal cancer, gastric cancer, general obesity, waist circumference, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR = 1.19; 95% CI, 0.63-2.22 and HR = 3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR = 0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR = 1.91; 1.09-3.37, and HR = 2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation.

Published
2015

7. A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk

Author

Aleksandrova, Krasimira, Chuang, Shu-Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, Bas, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattias, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J Ramón, Jakszyn, Paula, Sánchez, María-José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M, Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J, Freisling, Heinz, Gunter, Marc J, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, and Vineis, Paolo

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Colo-Rectal Cancer, Cancer, Clinical Research, Digestive Diseases, Adult, Aged, Biomarkers, Tumor, Case-Control Studies, Chromatography, Liquid, Colonic Neoplasms, Colorectal Neoplasms, Europe, Female, Humans, Immunity, Cellular, Male, Middle Aged, Neopterin, Odds Ratio, Prospective Studies, Rectal Neoplasms, Sensitivity and Specificity, T-Lymphocytes, Helper-Inducer, Tandem Mass Spectrometry, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference = .87) and after excluding case patients diagnosed within the first four follow-up years. These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.

Published
2015

8. Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).

Author

Jacobs, Eric J, Chanock, Stephen J, Fuchs, Charles S, Lacroix, Andrea, McWilliams, Robert R, Steplowski, Emily, Stolzenberg-Solomon, Rachael Z, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Petersen, Gloria, Zheng, Wei, Agalliu, Ilir, Allen, Naomi E, Amundadottir, Laufey, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Clipp, Sandra, Dorronsoro, Miren, Gaziano, J Michael, Giovannucci, Edward L, Hankinson, Susan E, Hartge, Patricia, Hoover, Robert N, Hunter, David J, Jacobs, Kevin B, Jenab, Mazda, Kraft, Peter, Kooperberg, Charles, Lynch, Shannon M, Sund, Malin, Mendelsohn, Julie B, Mouw, Tracy, Newton, Christina C, Overvad, Kim, Palli, Domenico, Peeters, Petra HM, Rajkovic, Aleksandar, Shu, Xiao-Ou, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M, Yu, Kai, and Zeleniuch-Jacquotte, Anne

Subjects
Humans, Pancreatic Neoplasms, Genetic Predisposition to Disease, Case-Control Studies, Cohort Studies, Genome-Wide Association Study, Colo-Rectal Cancer, Clinical Research, Rare Diseases, Aging, Cancer, Digestive Diseases, Prostate Cancer, Ovarian Cancer, Pancreatic Cancer, Breast Cancer, Prevention, Urologic Diseases, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.

Published
2010

9. Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

Author

Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Quirós, J. Ramón, Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., and Wareham, Nicholas J.

Published
2018
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10. Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort

Author

Emaus, Marleen J, Peeters, Petra HM, Bakker, Marije F, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Romieu, Isabelle, Ferrari, Pietro, Dossus, Laure, Boutron-Ruault, Marie Christine, Baglietto, Laura, Fortner, Renée T, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Skeie, Guri, Lund, Eiliv, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Winkvist, Anna, Wennberg, Maria, Bueno-de-Mesquita, H Bas, Khaw, Kay-Tee, Travis, Ruth C, Key, Timothy J, Aune, Dagfinn, Gunter, Marc, Riboli, Elio, and van Gils, Carla H

Published
2016
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11. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition

Author

Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-de-Mesquita, H Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni-Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H, Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J Ramón, Luján-Barroso, Leila, Sánchez, María-José, Chilarque, Maria-Dolores, Ardanas, Eva, Dorronsoro, Miren, Nilsson, Lena Maria, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J, Riboli, Elio, Boeing, Heiner, and Trichopoulos, Dimitrios

Published
2015
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12. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

Author

Zheng, Ju-Sheng, Luan, Jian'an, Sofianopoulou, Eleni, Sharp, Stephen J., Day, Felix R., Imamura, Fumiaki, Gundersen, Thomas E., Lotta, Luca A., Sluijs, Ivonne, Stewart, Isobel D., Shah, Rupal L., van der Schouw, Yvonne T., Wheeler, Eleanor, Ardanaz, Eva, Boeing, Heiner, Dorronsoro, Miren, Dahm, Christina C., Dimou, Niki, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Huerta, José María, Heath, Alicia K., Hansen, Louise, Jenab, Mazda, Jakszyn, Paula, Kaaks, Rudolf, Kühn, Tilman, Khaw, Kay-Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Olsen, Anja, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Spijkerman, Annemieke M. W., Tong, Tammy Y. N., Tumino, Rosario, Tsilidis, Konstantinos K., Danesh, John, Riboli, Elio, Butterworth, Adam S., Langenberg, Claudia, Forouhi, Nita G., and Wareham, Nicholas J.

Subjects
Vitamin D deficiency -- Complications and side effects -- Physiological aspects -- Genetic aspects, Type 2 diabetes -- Risk factors -- Development and progression -- Genetic aspects, Biological sciences
Abstract

Background Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D.sub.3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D.sub.3) positively associated with T2D. Whether or not these observational associations are causal remains uncertain. We aimed to examine the potential causality of these associations using Mendelian randomisation (MR) analysis. Methods and findings We performed a meta-analysis of genome-wide association studies for total 25(OH)D (N = 120,618), 25(OH)D.sub.3 (N = 40,562), and C3-epi-25(OH)D.sub.3 (N = 40,562) in participants of European descent (European Prospective Investigation into Cancer and Nutrition [EPIC]-InterAct study, EPIC-Norfolk study, EPIC-CVD study, Ely study, and the SUNLIGHT consortium). We identified genetic variants for MR analysis to investigate the causal association of the 25(OH)D metabolites with T2D (including 80,983 T2D cases and 842,909 non-cases). We also estimated the observational association of 25(OH)D metabolites with T2D by performing random effects meta-analysis of results from previous studies and results from the EPIC-InterAct study. We identified 10 genetic loci associated with total 25(OH)D, 7 loci associated with 25(OH)D.sub.3 and 3 loci associated with C3-epi-25(OH)D.sub.3 . Based on the meta-analysis of observational studies, each 1-standard deviation (SD) higher level of 25(OH)D was associated with a 20% lower risk of T2D (relative risk [RR]: 0.80; 95% CI 0.77, 0.84; p < 0.001), but a genetically predicted 1-SD increase in 25(OH)D was not significantly associated with T2D (odds ratio [OR]: 0.96; 95% CI 0.89, 1.03; p = 0.23); this result was consistent across sensitivity analyses. In EPIC-InterAct, 25(OH)D.sub.3 (per 1-SD) was associated with a lower risk of T2D (RR: 0.81; 95% CI 0.77, 0.86; p < 0.001), while C3-epi-25(OH)D.sub.3 (above versus below lower limit of quantification) was positively associated with T2D (RR: 1.12; 95% CI 1.03, 1.22; p = 0.006), but neither 25(OH)D.sub.3 (OR: 0.97; 95% CI 0.93, 1.01; p = 0.14) nor C3-epi-25(OH)D.sub.3 (OR: 0.98; 95% CI 0.93, 1.04; p = 0.53) was causally associated with T2D risk in the MR analysis. Main limitations include the lack of a non-linear MR analysis and of the generalisability of the current findings from European populations to other populations of different ethnicities. Conclusions Our study found discordant associations of biochemically measured and genetically predicted differences in blood 25(OH)D with T2D risk. The findings based on MR analysis in a large sample of European ancestry do not support a causal association of total 25(OH)D or 25(OH)D metabolites with T2D and argue against the use of vitamin D supplementation for the prevention of T2D., Author(s): Ju-Sheng Zheng 1,2,*, Jian'an Luan 1, Eleni Sofianopoulou 3,4, Stephen J. Sharp 1, Felix R. Day 1, Fumiaki Imamura 1, Thomas E. Gundersen 5, Luca A. Lotta 1, Ivonne [...]

Published
2020
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14. Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study

Author

Steins Bisschop, Charlotte N, van Gils, Carla H, Emaus, Marleen J, Bueno-de-Mesquita, H Bas, Monninkhof, Evelyn M, Boeing, Heiner, Aleksandrova, Krasmira, Jenab, Mazda, Norat, Teresa, Riboli, Elio, Boutron-Rualt, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Naccarati, Alessio, Mattiello, Amalia, Argüelles, Marcial Vicente, Sanchez, Maria José, Tormo, Maria José, Ardanaz, Eva, Dorronsoro, Miren, Bonet, Catalina, Khaw, Kay-Tee, Key, Tim, Trichopoulou, Antonia, Orfanos, Philippos, Naska, Androniki, Kaaks, Rudolph R, Lukanova, Annekatrin, Pischon, Tobias, Ljuslinder, Ingrid, Jirström, Karin, Ohlsson, Bodil, Overvad, Kim, Landsvig Berentzen, Tina, Halkjaer, Jytte, Tjonneland, Anne, Weiderpass, Elisabete, Skeie, Guri, Braaten, Tonje, Siersema, Peter D, Freisling, Heinz, Ferrari, Pietro, Peeters, Petra HM, and May, Anne M

Published
2014
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15. Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort

Author

Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael, Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Benjaminsen Borch, Kristin, Oluwafemi Oyeyemi, Sunday, Quirós, Ramón J, Bonet, Catalina, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nicholas, Assi, Nada, Ward, Heather A, Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner

Published
2017
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16. Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Author

Michaud, Dominique S., Izard, Jacques, Rubin, Zachary, Johansson, Ingegerd, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Dossus, Laure, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Naska, Androniki, Ziara, Giana, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H. M., Siersema, Peter D., Barricarte, Aurelio, Huerta, José-María, Molina-Montes, Esther, Dorronsoro, Miren, Quirós, J. Ramón, Duell, Eric J., Ohlsson, Bodil, Jeppsson, Bengt, Johansson, Anders, Lif, Pernilla, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Key, Tim J., Freisling, Heinz, Duarte-Salles, Talita, Stepien, Magdalena, Riboli, Elio, and Bueno-de-Mesquita, H. Bas

Published
2013

17. Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer: Results From the European Prospective Investigation into Nutrition and Cancer Study

Author

Bhoo–Pathy, Nirmala, Uiterwaal, Cuno S.P.M., Dik, Vincent K., Jeurnink, Suzanne M., Bech, Bodil H., Overvad, Kim, Halkjær, Jytte, Tjønneland, Anne, Boutron–Ruault, Marie–Christine, Fagherazzi, Guy, Racine, Antoine, Katzke, Verena A., Li, Kuanrong, Boeing, Heiner, Floegel, Anna, Androulidaki, Anna, Bamia, Christina, Trichopoulou, Antonia, Masala, Giovanna, Panico, Salvatore, Crosignani, Paolo, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H.M., Gavrilyuk, Oxana, Skeie, Guri, Weiderpass, Elisabete, Duell, Eric J., Arguelles, Marcial, Molina–Montes, Esther, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Björn, Wallström, Peter, Sund, Malin, Ye, Weimin, Khaw, Kay–Tee, Wareham, Nick, Key, Timothy J., Travis, Ruth C., Duarte–Salles, Talita, Freisling, Heinz, Licaj, Idlir, Gallo, Valentina, Michaud, Dominique S., Riboli, Elio, and Bueno–De–Mesquita, H. Bas

Published
2013
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18. Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Hosnijeh, Fatemeh Saberi, Christopher, Yvette, Peeters, Petra, Romieu, Isabelle, Xun, Wei, Riboli, Elio, Raaschou-Nielsen, Ole, Tjønneland, Anne, Becker, Nikolaus, Nieters, Alexandra, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philip, Oddone, Enrico, Luján-Barroso, Leila, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Molina-Montes, Esther, Wareham, Nick, Vineis, Paolo, and Vermeulen, Roel

Published
2013
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19. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Hosnijeh, Fatemeh Saberi, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, Tjønneland, Anne, Halkjær, Jytte, Fagherazzi, Guy, Clavel-Chapelon, Françoise, Dossus, Laure, Lukanova, Annie, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Katsoulis, Michael, Panico, Salvatore, Tagliabue, Giovanna, Bonet, Catalina, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Sánchez, Maria-José, Johansen, Dorthe, Borgquist, Signe, Peeters, Petra, Bueno-de-Mesquita, H. Bas, Ros, Martine M., Travis, Ruth C., Key, Timothy J., Vineis, Paolo, and Vermeulen, Roel

Published
2013

20. Validity of self-reported prevalent cases of stroke and acute myocardial infarction in the Spanish cohort of the EPIC study

Author

Machón, Monica, Arriola, Larraitz, Larrañaga, Nerea, Amiano, Pilar, Moreno-Iribas, Concepción, Agudo, Antonio, Ardanaz, Eva, Barricarte, Aurelio, Buckland, Genevieve, Chirlaque, MaDolores, Gavrila, Diana, Huerta, José María, Martínez, Carmen, Molina, Esther, Navarro, Carmen, Quiros, José Ramón, Rodríguez, Laudina, Sanchez, María José, González, Carlos Alberto, and Dorronsoro, Miren

Published
2013

21. Mediterranean diet and colorectal cancer risk: results from a European cohort

Author

Bamia, Christina, Lagiou, Pagona, Buckland, Genevieve, Grioni, Sara, Agnoli, Claudia, Taylor, Aliki J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Cottet, Vanessa, Boutron-Ruault, Marie-Christine, Morois, Sophie, Grote, Verena, Teucher, Birgit, Boeing, Heiner, Buijsse, Brian, Trichopoulos, Dimitrios, Adarakis, George, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Palli, Domenico, Bueno-de-Mesquita, H. Bas, van Duijnhoven, Fränzel J. B., Peeters, Petra H. M., Engeset, Dagrun, Skeie, Guri, Lund, Eiliv, Sánchez, Maria-José, Barricarte, Aurelio, Huerta, Jose-Maria, Quirós, J. Ramón, Dorronsoro, Miren, Ljuslinder, Ingrid, Palmqvist, Richard, Drake, Isabel, Key, Timothy J., Khaw, Kay-Tee, Wareham, Nick, Romieu, Isabelle, Fedirko, Veronika, Jenab, Mazda, Romaguera, Dora, Norat, Teresa, and Trichopoulou, Antonia

Published
2013
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22. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan

Published
2015
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23. Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study

Author

Romaguera, Dora, Vergnaud, Anne-Claire, Peeters, Petra H, van Gils, Carla H, Chan, Doris SM, Ferrari, Pietro, Romieu, Isabelle, Jenab, Mazda, Slimani, Nadia, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Perquier, Florence, Kaaks, Rudolf, Teucher, Birgit, Boeing, Heiner, von Rüsten, Anne, Tjønneland, Anne, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Quirós, José Ramón, Gonzalez, Carlos A, Sánchez, María José, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca L, Key, Timothy J, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Masala, Giovanna, Vineis, Paolo, Tumino, Rosario, Sieri, Sabina, Panico, Salvatore, May, Anne M, Bueno-de-Mesquita, H Bas, Büchner, Frederike L, Wirfält, Elisabet, Manjer, Jonas, Johansson, Ingegerd, Hallmans, Göran, Skeie, Guri, Benjaminsen Borch, Kristin, Parr, Christine L, Riboli, Elio, and Norat, Teresa

Published
2012
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24. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Chuang, Shu-Chun, Norat, Teresa, Murphy, Neil, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Boutron-Ruault, Marie Christine, Perquier, Florence, Dartois, Laureen, Kaaks, Rudolf, Teucher, Birgit, Bergmann, Manuela M, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Grioni, Sara, Sacerdote, Carlotta, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Peeters, Petra HM, Bueno-de-Mesquita, Bas, Ros, Martine M, Brustad, Magritt, Åsli, Lene Angell, Skeie, Guri, Quirós, J Ramón, González, Carlos A, Sánchez, María-José, Navarro, Carmen, Ardanaz Aicua, Eva, Dorronsoro, Miren, Drake, Isabel, Sonestedt, Emily, Johansson, Ingegerd, Hallmans, Göran, Key, Timothy, Crowe, Francesca, Khaw, Kay-Tee, Wareham, Nicholas, Ferrari, Pietro, Slimani, Nadia, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, and Vineis, Paolo

Published
2012
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25. Olive oil intake and mortality within the Spanish population (EPIC-Spain)

Author

Buckland, Genevieve, Mayén, Ana Lucia, Agudo, Antonio, Travier, Noemie, Navarro, Carmen, Huerta, José María, Chirlaque, María Dolores, Barricarte, Aurelio, Ardanaz, Eva, Moreno-Iribas, Conchi, Marin, Pilar, Quirós, J Ramón, Redondo, María-Luisa, Amiano, Pilar, Dorronsoro, Miren, Arriola, Larraitz, Molina, Esther, Sanchez, María-José, and Gonzalez, Carlos A

Published
2012
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26. Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

Author

Braem, Marieke GM, Onland-Moret, N Charlotte, Schouten, Leo J, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C, Overvad, Kim, Lukanova, Annekatrin, Dossus, Laure, Floegel, Anna, Boeing, Heiner, Clavel-Chapelon, Francoise, Chabbert-Buffet, Nathalie, Fagherazzi, Guy, Trichopoulou, Antonia, Benetou, Vassiliki, Goufa, Ioulia, Pala, Valeria, Galasso, Rocco, Mattiello, Amalia, Sacerdote, Carlotta, Palli, Domenico, Tumino, Rosario, Gram, Inger T, Lund, Eiliv, Gavrilyuk, Oxana, Sánchez, Maria-José, Quirós, Ramón, Gonzales, Carlos A, Dorronsoro, Miren, Castaño, José M Huerta, Gurrea, Aurelio Barricarte, Idahl, Annika, Ohlson, Nina, Lundin, Eva, Jirstrom, Karin, Wirfalt, Elisabet, Allen, Naomi E, Tsilidis, Konstantinos K, Kaw, Kay-Tee, Bueno-de-Mesquita, H Bas, Dik, Vincent K, Rinaldi, Sabina, Fedirko, Veronika, Norat, Teresa, Riboli, Elio, Kaaks, Rudolf, and Peeters, Petra HM

Published
2012
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27. Consumption of meat and fish and risk of lung cancer: results from the European Prospective Investigation into Cancer and Nutrition

Author

Linseisen, Jakob, Rohrmann, Sabine, Bueno-de-Mesquita, Bas, Büchner, Frederike L., Boshuizen, Hendriek C., Agudo, Antonio, Gram, Inger Torhild, Dahm, Christina C., Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Boeing, Heiner, Steffen, Annika, Kaaks, Rudolf, Lukanova, Annekatrin, Berrino, Franco, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Ardanaz, Eva, Dorronsoro, Miren, Huerta, José-Maria, Rodríguez, Laudina, Sánchez, María-José, Rasmuson, Torgny, Hallmans, Göran, Manjer, Jonas, Wirfält, Elisabet, Engeset, Dagrun, Skeie, Guri, Katsoulis, Michael, Oikonomou, Eleni, Trichopoulou, Antonia, Peeters, Petra H. M., Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi, Key, Tim, Brennan, Paul, Romieu, Isabelle, Slimani, Nadia, Vergnaud, Anne-Claire, Xun, Wei W., Vineis, Paolo, and Riboli, Elio

Published
2011

28. Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival

Author

Johansson, Mattias, Fanidi, Anouar, Muller, David C., Bassett, Julie K., Midttun, Øivind, Vollset, Stein Emil, Travis, Ruth C., Palli, Domenico, Mattiello, Amalia, Sieri, Sabina, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Ljungberg, Börje, Hallmans, Göran, Weiderpass, Elisabete, Skeie, Guri, González, Carlos A., Dorronsoro, Miren, Peeters, Petra H., Bueno-de-Mesquita, H. B(as)., Ros, Martine M., Boutron Ruault, Marie-Christine, Fagherazzi, Guy, Clavel, Françoise, Sánchez, María-José, Gurrea, Aurelio Barricarte, Navarro, Carmen, Quiros, J. Ramon, Overvad, Kim, Tjønneland, Anne, Aleksandrova, Krassimira, Vineis, Paolo, Gunter, Marc J., Kaaks, Rudolf, Giles, Graham, Relton, Caroline, Riboli, Elio, Boeing, Heiner, Ueland, Per Magne, Severi, Gianluca, and Brennan, Paul

Published
2014
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29. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A

Published
2011
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30. Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Author

Chajès, Véronique, Jenab, Mazda, Romieu, Isabelle, Ferrari, Pietro, Dahm, Christina C, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Engel, Pierre, Teucher, Birgit, Kaaks, Rudolf, Floegel, Anna, Boeing, Heiner, Trichopoulou, Antonia, Dilis, Vardis, Karapetyan, Tina, Mattiello, Amalia, Tumino, Rosario, Grioni, Sara, Palli, Domenico, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Numans, Mattijs E, Peeters, Petra HM, Lund, Eiliv, Navarro, Carmen, Quirós, Jose Ramón, Sánchez-Cantalejo, Emilio, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Regnér, Sara, Sonestedt, Emily, Wirfält, Elisabet, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Crowe, Francesca L, Rinaldi, Sabina, Slimani, Nadia, Carneiro, Fatima, Riboli, Elio, and González, Carlos A

Published
2011
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31. Occupational Exposures, Environmental Tobacco Smoke, and Lung Cancer

Author

Veglia, Fabrizio, Vineis, Paolo, Overvad, Kim, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Linseisen, Jakob, Steindorf, Karen, Raaschou-Nielsen, Ole, Tjønneland, Anne, Gonzalez, Carlos A., Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Cirera, Lluis, Quiros, J. Ramon, Day, Nicholas E., Saracci, Rodolfo, and Riboli, Elio

Published
2007
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32. Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption

Author

Celorrio, David, Muñoz, Xavier, Amiano, Pilar, Dorronsoro, Miren, Bujanda, Luis, Sánchez, María-José, Molina-Montes, Esther, Navarro, Carmen, Chirlaque, M. Dolores, MaríaHuerta, José, Ardanaz, Eva, Barricarte, Aurelio, Rodriguez, Laudina, Duell, Eric J., Hijona, Elizabeth, Herreros-Villanueva, Marta, Sala, Núria, Alfonso-Sánchez, Miguel A., and de Pancorbo, Marian M.

Published
2016
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33. Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Author

Michaud, Dominique S, Gallo, Valentina, Schlehofer, Brigitte, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Teucher, Birgit, Lukanova, Annekatrin, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Lagiou, Pagona, Kyrozis, Andreas, Sacerdote, Carlotta, Krogh, Vittorio, Masala, Giovanna, Tumino, Rosario, Mattiello, Amalia, Bueno-de-Mesquita, H Bas, Ros, Martine M, Peeters, Petra HM, van Gils, Carla H, Skeie, Guri, Engeset, Dagrun, Parr, Christine L, Ardanaz, Eva, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Sánchez, Maria José, Argüelles, Marcial, Jakszyn, Paula, Nilsson, Lena M, Melin, Beatrice S, Manjer, Jonas, Wirfält, Elisabet, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Key, Timothy J, Romieu, Isabelle, Vineis, Paolo, and Riboli, Elio

Published
2010
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34. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition

Author

van Duijnhoven, Fränzel JB, Bueno-De-Mesquita, H Bas, Ferrari, Pietro, Jenab, Mazda, Boshuizen, Hendriek C, Ros, Martine M, Casagrande, Corinne, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Thorlacius-Ussing, Ole, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Nöthlings, Ute, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Misirli, Gesthimani, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra HM, van Gils, Carla H, Ocké, Marga C, Lund, Eiliv, Engeset, Dagrun, Skeie, Guri, Suárez, Laudina Rodríguez, González, Carlos A, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Berglund, Göran, Manjer, Jonas, Hallmans, Göran, Palmqvist, Richard, Bingham, Sheila A, Khaw, Kay-Tee, Key, Timothy J, Allen, Naomi E, Boffetta, Paolo, Slimani, Nadia, Rinaldi, Sabina, Gallo, Valentina, Norat, Teresa, and Riboli, Elio

Published
2009
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35. Circulating 25-Hydroxyvitamin D3 in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort

Author

Muller, David C., Fanidi, Anouar, Midttun, Øivind, Steffen, Annika, Dossus, Laure, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Kühn, Tilman, Katzke, Verena, de la Torre, Ramón Alonso, González, Carlos A., Sánchez, María-José, Dorronsoro, Miren, Santiuste, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Giotaki, Maria, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Tjønneland, Anne, Olsen, Anja, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Ljungberg, Börje, Wennberg, Maria, Weiderpass, Elisabete, Murphy, Neil, Riboli, Elio, Ueland, Per Magne, Boeing, Heiner, Brennan, Paul, and Johansson, Mattias

Published
2014
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36. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Saberi Hosnijeh, Fatemeh, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, Tjønneland, Anne, Halkjær, Jytte, Fagherazzi, Guy, Clavel-Chapelon, Françoise, Dossus, Laure, Lukanova, Annie, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Katsoulis, Michael, Panico, Salvatore, Tagliabue, Giovanna, Bonet, Catalina, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Sánchez, Maria-José, Johansen, Dorthe, Borgquist, Signe, Peeters, Petra, Bueno-de-Mesquita, H. Bas, Ros, Martine M., Travis, Ruth C., Key, Timothy J., Vineis, Paolo, and Vermeulen, Roel

Published
2013
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37. Unfavourable life-course social gradient of coronary heart disease within Spain: a low-incidence welfare-state country

Author

Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Buckland, Genevieve, Larrañaga, Nerea, Sánchez, María José, Agudo, Antonio, Amiano, Pilar, Quirós, José Ramón, Ardanaz, Eva, Arriola, Larraitz, Molina, Esther, Dorronsoro, Miren, Barricarte, Aurelio, González, Carlos A., Moreno-Iribas, Concepción, and Navarro, Carmen

Published
2013
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38. Aromatic adducts and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort

Author

Gilberson, Tamra, Peluso, Marco E.M., Munia, Armelle, Luján-Barroso, Leila, Sánchez, María-José, Navarro, Carmen, Amiano, Pilar, Barricarte, Aurelio, Quirós, Ramón J., Molina-Montes, Esther, Sánchez-Cantalejo, Emilio, Tormo, María-José, Chirlaque, María-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Confortini, Massimo, Bonet, Catalina, Sala, Núria, González, Carlos A., and Agudo, Antonio

Published
2014
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39. Genome-wide interaction study of smoking and bladder cancer risk

Author

Figueroa, Jonine D., Han, Summer S., Garcia-Closas, Montserrat, Baris, Dalsu, Jacobs, Eric J., Kogevinas, Manolis, Schwenn, Molly, Malats, Nuria, Johnson, Alison, Purdue, Mark P., Caporaso, Neil, Landi, Maria Teresa, Prokunina-Olsson, Ludmila, Wang, Zhaoming, Hutchinson, Amy, Burdette, Laurie, Wheeler, William, Vineis, Paolo, Siddiq, Afshan, Cortessis, Victoria K., Kooperberg, Charles, Cussenot, Olivier, Benhamou, Simone, Prescott, Jennifer, Porru, Stefano, Bueno-de-Mesquita, Bas H., Trichopoulos, Dimitrios, Ljungberg, Börje, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Krogh, Vittorio, Dorronsoro, Miren, Travis, Ruth, Tjønneland, Anne, Brenan, Paul, Chang-Claude, Jenny, Riboli, Elio, Conti, David, Gago-Dominguez, Manuela, Stern, Mariana C., Pike, Malcolm C., Van Den Berg, David, Yuan, Jian-Min, Hohensee, Chancellor, Rodabough, Rebecca, Cancel-Tassin, Geraldine, Roupret, Morgan, Comperat, Eva, Chen, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J., Kraft, Peter, Lindstrom, Sara, Carta, Angela, Pavanello, Sofia, Arici, Cecilia, Mastrangelo, Giuseppe, Karagas, Margaret R., Schned, Alan, Armenti, Karla R., Hosain, Monawar G.M., Haiman, Chris A., Fraumeni, Joseph F., Jr, Chanock, Stephen J., Chatterjee, Nilanjan, Rothman, Nathaniel, and Silverman, Debra T.

Published
2014
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40. Genome-wide association study identifies multiple loci associated with bladder cancer risk

Author

Figueroa, Jonine D., Ye, Yuanqing, Siddiq, Afshan, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Prokunina-Olsson, Ludmila, Cortessis, Victoria K., Kooperberg, Charles, Cussenot, Olivier, Benhamou, Simone, Prescott, Jennifer, Porru, Stefano, Dinney, Colin P., Malats, Núria, Baris, Dalsu, Purdue, Mark, Jacobs, Eric J., Albanes, Demetrius, Wang, Zhaoming, Deng, Xiang, Chung, Charles C., Tang, Wei, Bas Bueno-de-Mesquita, H., Trichopoulos, Dimitrios, Ljungberg, Börje, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Krogh, Vittorio, Dorronsoro, Miren, Travis, Ruth, Tjønneland, Anne, Brenan, Paul, Chang-Claude, Jenny, Riboli, Elio, Conti, David, Gago-Dominguez, Manuela, Stern, Mariana C., Pike, Malcolm C., Van Den Berg, David, Yuan, Jian-Min, Hohensee, Chancellor, Rodabough, Rebecca, Cancel-Tassin, Geraldine, Roupret, Morgan, Comperat, Eva, Chen, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J., Kraft, Peter, Lindstrom, Sara, Carta, Angela, Pavanello, Sofia, Arici, Cecilia, Mastrangelo, Giuseppe, Kamat, Ashish M., Lerner, Seth P., Barton Grossman, H., Lin, Jie, Gu, Jian, Pu, Xia, Hutchinson, Amy, Burdette, Laurie, Wheeler, William, Kogevinas, Manolis, Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Lloreta, Josep, Schwenn, Molly, Karagas, Margaret R., Johnson, Alison, Schned, Alan, Armenti, Karla R., Hosain, G.M., Andriole, Gerald, Jr, Grubb, Robert, III, Black, Amanda, Ryan Diver, W., Gapstur, Susan M., Weinstein, Stephanie J., Virtamo, Jarmo, Haiman, Chris A., Landi, Maria T., Caporaso, Neil, Fraumeni, Joseph F., Jr, Vineis, Paolo, Wu, Xifeng, Silverman, Debra T., Chanock, Stephen, and Rothman, Nathaniel

Published
2014
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42. Methodological challenges in the application of the glycemic index in epidemiological studies using data from the European Prospective Investigation into Cancer and Nutrition

Author

van Bakel, Marit M.E., Slimani, Nadia, Feskens, Edith J.M., Du, Huaidong, Beulens, Joline W.J., van der Schouw, Yvonne T., Brighenti, Furio, Halkjaer, Jytte, Cust, Anne E., Ferrari, Pietro, Brand-Miller, Jennie, Bueno-de-Mesquita, H. Bas, Peeters, Petra, Ardanaz, Eva, Dorronsoro, Miren, Crowe, Francesca L., Bingham, Sheila, Rohrmann, Sabine, Boeing, Heiner, Johansson, Ingegerd, Manjer, Jonas, Tjonneland, Anne, Overvad, Kim, Lund, Eiliv, Skeie, Guri, Mattiello, Amalia, Salvini, Simonetta, Clavel-Chapelon, Francoise, and Kaaks, Rudolf

Subjects
Glycemic index -- Usage, Glycemic index -- Health aspects, Epidemiologic methods -- Research, Cancer -- Diet therapy, Food/cooking/nutrition
Abstract

Associations between the glycemic index (GI) or glycemic load (GL) and diseases are heterogeneous in epidemiological studies. Differences in assigning GI values to food items may contribute to this inconsistency. Our objective was to address methodological issues related to the use of current GI and GL values in epidemiological studies. We performed ecological comparison and correlation studies by calculating dietary GI and GL from country-specific dietary questionnaires (DQ) from 422,837 participants from 9 countries participating in the European Prospective Investigation into Cancer and Nutrition study and single standardized 24-h dietary recalls (24-HDR) obtained from a representative sample (n = 33,404) using mainly Foster Powell's international table as a reference source. Further, 2 inter-rater and 1 inter-method comparison were conducted, comparing DQ GI values assigned by independent groups with values linked by us. The ecological correlation between DQ and 24-HDR was good for GL (overall r = 0.76; P < 0.005) and moderate for GI (r = 0.57; P < 0.05). Mean GI/GL differences between DQ and 24-HDR were significant for most centers. GL but not GI from DQ was highly correlated with total carbohydrate (r = 0.98 and 0.15, respectively; P < 0.0001) and this was higher for starch (r = 0.72; P < 0.0001) than for sugars (r = 0.36; P < 0.0001). The inter-rater and inter-method variations were considerable for GI (weighted [kappa] coefficients of 0.49 and 0.65 for inter-rater and 0.25 for inter- method variation, respectively) but only mild for G L (weighted [kappa] coefficients > 0.80). A more consistent methodology to attribute GI values to foods and validated DQ is needed to derive meaningful GI/GL estimates for nutritional epidemiology.

Published
2009

43. The Sum of Plasma Fatty Acids iso16:0, iso17:0, trans11-18:1, cis9, trans11-CLA, and cis6-18:1 as Biomarker of Dairy Intake Established in an Intervention Study and Validated in the EPIC Cohort of Gipuzkoa

Author

Berriozabalgoitia, Alaitz, primary, Gordoa, Juan Carlos Ruiz de, additional, Renobales, Mertxe de, additional, Amores, Gustavo, additional, Barron, Luis Javier R., additional, Amiano, Pilar, additional, Dorronsoro, Miren, additional, Perea, Zelai, additional, and Virto, Mailo, additional

Published
2021
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44. Adherence to a Mediterranean diet is associated with reduced 3-year incidence of obesity

Author

Mendez, Michelle A., Popkin, Barry M., Jakszyn, Paula, Berenguer, Antonio, Tormo, Maria Jose, Sanchez, Maria Jose, Quiros, Jose R., Pera, Guillem, Navarro, Carmen, Martinez, Carmen, Larranaga, Nerea, Dorronsoro, Miren, Chirlaque, Maria Dolores, Barricarte, Aurelio, Ardanaz, Eva, Amiano, Pilar, Agudo, Antonio, and Gonzalez, Carlos A.

Subjects
Obesity -- Prevention, Food/cooking/nutrition
Abstract

Few studies have prospectively examined dietary patterns and adult weight change, and results to date are inconsistent. This study examines whether a Mediterranean diet (MD) pattern is associated with reduced 3-y incidence of obesity using data from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The sample included 17,238 women and 10,589 men not obese and aged 29-65 y at baseline (1992-96). Height and weight were measured at baseline; weight was self-reported in a follow-up survey a mean of 3.3 y later. Detailed dietary history data, collected using a validated method, were used to construct a MD score. Logistic regression models were used to estimate odds of becoming overweight or obese. Among initially overweight subjects, 7.9% of women and 6.9% of men became obese, whereas 13.8% of normal weight men and 23.0% women became overweight. High MD adherence was associated with significantly lower likelihood of becoming obese among overweight subjects, with stronger associations after adjusting for underreporting of dietary data. Associations (odds ratios with 95% CI) were similar in women (0.69, 0.54-0.89) and men (0.68, 0.53-0.89). Adjusting for the plausibility of reported dietary intakes increased the magnitude of these associations, which were ~0.8 without this adjustment. MD adherence was not associated with incidence of overweight in initially normal-weight subjects. Nonetheless, results suggest that promoting eating habits consistent with MD patterns may be a useful part of efforts to combat obesity.

Published
2006

45. Greenhouse gases emissions from the diet and risk of death and chronic diseases in the EPIC-Spain cohort

Author

González, Carlos A, primary, Bonet, Catalina, additional, de Pablo, Miguel, additional, Sanchez, María José, additional, Salamanca-Fernandez, Elena, additional, Dorronsoro, Miren, additional, Amiano, Pilar, additional, Huerta, Jose María, additional, Chirlaque, María Dolores, additional, Ardanaz, Eva, additional, Barricarte, Aurelio, additional, Quirós, Jose Ramón, additional, Agudo, Antonio, additional, and Rivera Ferrer, Marta Guadalupe, additional

Published
2020
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46. Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Saberi Hosnijeh, Fatemeh, Christopher, Yvette, Peeters, Petra, Romieu, Isabelle, Xun, Wei, Riboli, Elio, Raaschou-Nielsen, Ole, Tjønneland, Anne, Becker, Nikolaus, Nieters, Alexandra, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philip, Oddone, Enrico, Luján-Barroso, Leila, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Molina-Montes, Esther, Wareham, Nick, Vineis, Paolo, and Vermeulen, Roel

Published
2013
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47. Physical Activity and Risk of Cerebrovascular Disease in the European Prospective Investigation Into Cancer and Nutrition-Spain Study

Author

Huerta, José María, Chirlaque, María-Dolores, Tormo, María-José, Gavrila, Diana, Arriola, Larraitz, Moreno-Iribas, Conchi, Amiano, Pilar, Ardanaz, Eva, Barricarte, Aurelio, Dorronsoro, Miren, Egüés, Nerea, Larrañaga, Nerea, Molina-Montes, Esther, Quirós, José Ramón, Sánchez, María-José, González, Carlos A., and Navarro, Carmen

Published
2013
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48. Response

Author

Trichopoulos, Dimitrios, Bamia, Christina, Lagiou, Pagona, Fedirko, Veronika, Trepo, Elisabeth, Jenab, Mazda, Pischon, Tobias, Nöthlings, Ute, Overvad, Kim, Tjønneland, Anne, Outzen, Malene, Clavel-Chapelon, Francoise, Kaaks, Rudolf, Lukanova, Annekatrin, Boeing, Heiner, Aleksandrova, Krasimira, Benetou, Vassiliki, Zylis, Dimosthenis, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-De-Mesquita, H. Bas, Van Kranen, Henk J., Peeters, Petra H. M., Lund, Eiliv, Quirós, J. Ramón, González, Carlos A., Sanchez Perez, Maria-Jose, Navarro, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Lindkvist, Björn, Regnér, Sara, Werner, Mårten, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy, Romieu, Isabelle, Chuang, Shu-Chun, Murphy, Neil, Boffetta, Paolo, Trichopoulou, Antonia, and Riboli, Elio

Published
2012
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49. Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study

Author

Aleksandrova, Krasimira, Boeing, Heiner, Jenab, Mazda, Bueno-de-Mesquita, H.Bas, Jansen, Eugene, van Duijnhoven, Fränzel J.B., Fedirko, Veronika, Rinaldi, Sabina, Romieu, Isabelle, Riboli, Elio, Romaguera, Dora, Westphal, Sabine, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Lukanova, Annekatrin, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Agnoli, Claudia, Mattiello, Amalia, Saieva, Calogero, Vineis, Paolo, Tumino, Rosario, Peeters, Petra H., Argüelles, Marcial, Bonet, Catalina, Sánchez, María-José, Dorronsoro, Miren, Huerta, Jose-María, Barricarte, Aurelio, Palmqvist, Richard, Hallmans, Göran, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E., Crowe, Francesca L., and Pischon, Tobias

Published
2012
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50. Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer: A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition

Author

Leufkens, Anke M., van Duijnhoven, Fränzel J. B., Woudt, Sjoukje H. S., Siersema, Peter D., Jenab, Mazda, Jansen, Eugene H. J. M., Pischon, Tobias, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Kaaks, Rudolf, Lukanova, Annekatrin, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Dilis, Vardis, Peeters, Petra H., Skeie, Guri, González, Carlos A., Argüelles, Marcial, Sánchez, María-José, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Hallmans, Göran, Palmqvist, Richard, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E., Crowe, Francesca L., Fedirko, Veronika, Norat, Teresa, Riboli, Elio, and Bueno-de-Mesquita, H. Bas

Published
2012
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