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1. Systemic exposure of floxuridine after hepatic arterial infusion pump chemotherapy with floxuridine in patients with resected colorectal liver metastases

Author

IJzerman, Nikki S., Filipe, Wills F., Bruijn, Peter de, Buisman, Florian E., Doorn, Leni van, Doornebosch, Pascal G., Holster, Jessica J., Grootscholten, Cecile, Grünhagen, Dirk J., van Bommel, Christian P.E., Homs, Marjolein Y.V., Kok, Niels F.M., Verhoef, Cornelis, Koerkamp, Bas Groot, Kuhlmann, Koert F.D., Mathijssen, Ron H.J., and Koolen, Stijn L.W.

Published
2023
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2. GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells

Author

Rakké, Yannick S., Campos Carrascosa, Lucia, van Beek, Adriaan A., de Ruiter, Valeska, van Gemerden, Rachelle S., Doukas, Michail, Doornebosch, Pascal G., Vermaas, Maarten, ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L.O., Kliffen, Mike, Grünhagen, Dirk J., Verhoef, Cornelis, IJzermans, Jan N.M., Kwekkeboom, Jaap, and Sprengers, Dave

Published
2023
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3. The association of cognitive coping style with patient preferences in a patient-led follow-up study among colorectal cancer survivors

Author

Voigt, Kelly R., Wullaert, Lissa, van Driel, M. H.Elise, Goudberg, Max, Doornebosch, Pascal G., Schreinemakers, Jennifer M.J., Verseveld, Maria, Peeters, Koen C.M.J., Verhoef, Cornelis, Husson, Olga, Grünhagen, Dirk J., Voigt, Kelly R., Wullaert, Lissa, van Driel, M. H.Elise, Goudberg, Max, Doornebosch, Pascal G., Schreinemakers, Jennifer M.J., Verseveld, Maria, Peeters, Koen C.M.J., Verhoef, Cornelis, Husson, Olga, and Grünhagen, Dirk J.

Abstract

Introduction: Amidst the rising number of cancer survivors and personnel shortages, optimisation of follow-up strategies is imperative, especially since intensive follow-up does not lead to survival benefits. Understanding patient preferences and identifying the associated patient profiles is crucial. Coping style may be a key determinant in achieving this. Our study aims to evaluate preferences, identify coping styles and their associated factors, and explore the association between coping style and patients’ preferences in colorectal cancer (CRC) follow-up. Methods: In a prospective multicentre implementation study, patients completed the Threatening Medical Situations Inventory (TMSI) to determine their coping style. Simultaneously patients choose their follow-up preferences for the CRC trajectory regarding frequency of tumour marker determination, location of blood sampling, and manner of contact. Results: A total of 188 patients completed the TMSI questionnaire after inclusion. A more intensive follow-up was preferred by 71.5% of patients. Of all patients, 52.0% had a coping style classified as ‘blunting’ and 34.0% as ‘monitoring’. Variables such as a younger age, female gender, higher educational level, and lower ASA scores were associated with having higher monitoring scores. However, there were no significant associations between follow-up preferences and patients’ coping styles. Conclusion: This study suggests that none of the provided options in a patient-led follow-up are unsuitable for patients who underwent curative surgery for primary CRC, based on coping style determined at baseline. Low-intensity surveillance after curative resection of CRC may, therefore, be suitable for a wide range of patients independent of coping styles.

Published
2024

4. Trends and overall survival after combined liver resection and thermal ablation of colorectal liver metastases:a nationwide population-based propensity score-matched study

Author

de Graaff, Michelle R., Klaase, Joost M., den Dulk, Marcel, Coolsen, Marielle M.E., Kuhlmann, Koert F.D., Verhoef, Cees, Hartgrink, Henk H., Derksen, Wouter J.M., van den Boezem, Peter, Rijken, Arjen M., Gobardhan, Paul, Liem, Mike S.L., Leclercq, Wouter K.G., Marsman, Hendrik A., van Duijvendijk, Peter, Bosscha, Koop, Elfrink, Arthur K.E., Manusama, Eric R., Belt, Eric J.Th, Doornebosch, Pascal G., Oosterling, Steven J., Ruiter, Simeon J.S., Grünhagen, Dirk J., Burgmans, Mark, Meijerink, Martijn, Kok, Niels F.M., Swijnenburg, Rutger Jan, Buis, Carlijn I., Hagendoorn, Jeroen, Torrenga, Hans, van Heek, N. Tjarda, Braat, Andries E., Hoogwater, Frederik J.H., Consten, Esther C.J., van der Leij, Christiaan, Patijn, Gijs, de Graaff, Michelle R., Klaase, Joost M., den Dulk, Marcel, Coolsen, Marielle M.E., Kuhlmann, Koert F.D., Verhoef, Cees, Hartgrink, Henk H., Derksen, Wouter J.M., van den Boezem, Peter, Rijken, Arjen M., Gobardhan, Paul, Liem, Mike S.L., Leclercq, Wouter K.G., Marsman, Hendrik A., van Duijvendijk, Peter, Bosscha, Koop, Elfrink, Arthur K.E., Manusama, Eric R., Belt, Eric J.Th, Doornebosch, Pascal G., Oosterling, Steven J., Ruiter, Simeon J.S., Grünhagen, Dirk J., Burgmans, Mark, Meijerink, Martijn, Kok, Niels F.M., Swijnenburg, Rutger Jan, Buis, Carlijn I., Hagendoorn, Jeroen, Torrenga, Hans, van Heek, N. Tjarda, Braat, Andries E., Hoogwater, Frederik J.H., Consten, Esther C.J., van der Leij, Christiaan, and Patijn, Gijs

Abstract

Background: In colorectal liver metastases (CRLM) patients, combination of liver resection and ablation permit a more parenchymal-sparing approach. This study assessed trends in use of combined resection and ablation, outcomes, and overall survival (OS). Methods: This population-based study included all CRLM patients who underwent liver resection between 2014 and 2022. To assess OS, data was linked to two databases containing date of death for patients treated between 2014 and 2018. Hospital variation in the use of combined minor liver resection and ablation versus major liver resection alone in patients with 2–3 CRLM and ≤3 cm was assessed. Propensity score matching (PSM) was applied to evaluate outcomes. Results: This study included 3593 patients, of whom 1336 (37.2%) underwent combined resection and ablation. Combined resection increased from 31.7% in 2014 to 47.9% in 2022. Significant hospital variation (range 5.9–53.8%) was observed in the use of combined minor liver resection and ablation. PSM resulted in 1005 patients in each group. Major morbidity was not different (11.6% vs. 5%, P = 1.00). Liver failure occurred less often after combined resection and ablation (1.9% vs. 0.6%, P = 0.017). Five-year OS rates were not different (39.3% vs. 33.9%, P = 0.145). Conclusion: Combined resection and ablation should be available and considered as an alternative to resection alone in any patient with multiple metastases.

Published
2024

5. Extrahepatic perfusion and incomplete hepatic perfusion after hepatic arterial infusion pump implantation:incidence and clinical implications

Author

Filipe, Wills F, Buisman, Florian E, Franssen, Stijn, Krul, Myrtle F, Grünhagen, Dirk J, Bennink, Roel J, Bolhuis, Karen, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, van Delden, Otto M, Doornebosch, Pascal G, Gobardhan, Paul D, Graven, Laura, de Groot, Jan Willem B, Grootscholten, Cecile, Hagendoorn, Jeroen, Harmsen, Paul, Homs, Marjolein Y V, Klompenhouwer, Elizabeth G, Kok, Niels F M, Lam, Marnix G E H, Loosveld, Olaf J L, Meier, Mark A J, Mieog, J Sven D, Oostdijk, Ad H J, Outmani, Loubna, Patijn, Gijs A, Pool, Stefan, Rietbergen, Daphne D D, Roodhart, Jeanine M L, Speetjens, Frank M, Swijnenburg, Rutger Jan, Versleijen, Michelle W J, Verhoef, Cornelis, Kuhlmann, Koert F D, Moelker, Adriaan, Groot Koerkamp, Bas, Filipe, Wills F, Buisman, Florian E, Franssen, Stijn, Krul, Myrtle F, Grünhagen, Dirk J, Bennink, Roel J, Bolhuis, Karen, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, van Delden, Otto M, Doornebosch, Pascal G, Gobardhan, Paul D, Graven, Laura, de Groot, Jan Willem B, Grootscholten, Cecile, Hagendoorn, Jeroen, Harmsen, Paul, Homs, Marjolein Y V, Klompenhouwer, Elizabeth G, Kok, Niels F M, Lam, Marnix G E H, Loosveld, Olaf J L, Meier, Mark A J, Mieog, J Sven D, Oostdijk, Ad H J, Outmani, Loubna, Patijn, Gijs A, Pool, Stefan, Rietbergen, Daphne D D, Roodhart, Jeanine M L, Speetjens, Frank M, Swijnenburg, Rutger Jan, Versleijen, Michelle W J, Verhoef, Cornelis, Kuhlmann, Koert F D, Moelker, Adriaan, and Groot Koerkamp, Bas

Abstract

INTRODUCTION: This study investigates the incidence of extrahepatic perfusion and incomplete hepatic perfusion at intraoperative methylene blue testing and on postoperative nuclear imaging in patients undergoing hepatic arterial infusion pump (HAIP) chemotherapy.METHODS:The first 150 consecutive patients who underwent pump implantation in the Netherlands were included. All patients underwent surgical pump implantation with the catheter in the gastroduodenal artery. All patients underwent intraoperative methylene blue testing and postoperative nuclear imaging ( 99mTc-Macroaggregated albumin SPECT/CT) to determine perfusion via the pump. RESULTS: Patients were included between January-2018 and December-2021 across eight centers. During methylene blue testing, 29.3% had extrahepatic perfusion, all successfully managed intraoperatively. On nuclear imaging, no clinically relevant extrahepatic perfusion was detected (0%, 95%CI: 0.0-2.5%). During methylene blue testing, 2.0% had unresolved incomplete hepatic perfusion. On postoperative nuclear imaging, 8.1% had incomplete hepatic perfusion, leading to embolization in only 1.3%.CONCLUSION: Methylene blue testing during pump placement for intra-arterial chemotherapy identified extrahepatic perfusion in 29.3% of patients, but could be resolved intraoperatively in all patients. Postoperative nuclear imaging found no clinically relevant extrahepatic perfusion and led to embolization in only 1.3% of patients. The role of routine nuclear imaging after HAIP implantation should be studied in a larger cohort.

Published
2024

6. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands

Author

Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, Oosterling, Steven, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H.C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K.G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W.J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Türkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., and Besselink, Marc G.

Published
2019
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7. B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients

Author

Vietsch, Eveline E., primary, Latifi, Diba, additional, Verheij, Maaike, additional, van der Oost, Elise W.A., additional, de Wilde, Roeland F., additional, Haen, Roel, additional, van den Boom, Anne Loes, additional, Koerkamp, Bas Groot, additional, Doornebosch, Pascal G., additional, van Verschuer, Victorien M.T., additional, Ooms, Ariadne H.A.G., additional, Mohammad, Farzana, additional, Willemsen, Marcella, additional, Aerts, Joachim G.J.V., additional, Krog, Ricki T., additional, de Miranda, Noel F.C.C., additional, van den Bosch, Thierry P.P., additional, Mueller, Yvonne M., additional, Katsikis, Peter D., additional, and van Eijck, Casper H.J., additional

Published
2023
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8. Patient-led home-based follow-up after surgery for colorectal cancer: the protocol of the prospective, multicentre FUTURE-primary implementation study

Author

Voigt, Kelly Raquel, primary, Wullaert, Lissa, additional, Höppener, Diederik J, additional, Schreinemakers, Jennifer M J, additional, Doornebosch, Pascal G, additional, Verseveld, Maria, additional, Peeters, Koen, additional, Verhoef, Cornelis, additional, Husson, Olga, additional, and Grünhagen, Dirk, additional

Published
2023
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9. Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients

Author

Dekkers, Nik, primary, Dang, Hao, additional, Vork, Katinka, additional, Langers, Alexandra M. J., additional, van der Kraan, Jolein, additional, Westerterp, Marinke, additional, Peeters, Koen C. M. J., additional, Holman, Fabian A., additional, Koch, Arjun D., additional, de Graaf, Wilmar, additional, Didden, Paul, additional, Moons, Leon M. G., additional, Doornebosch, Pascal G., additional, Hardwick, James C. H., additional, and Boonstra, Jurjen J., additional

Published
2023
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10. Perineal wound closure using gluteal turnover flap or primary closure after abdominoperineal resection for rectal cancer: study protocol of a randomised controlled multicentre trial (BIOPEX-2 study)

Author

Sharabiany, Sarah, Blok, Robin D., Lapid, Oren, Hompes, Roel, Bemelman, Wilhelmus A., Alberts, Victor P., Lamme, Bas, Wijsman, Jan H., Tuynman, Jurriaan B., Aalbers, Arend G. J., Beets, Geerard L., Fabry, Hans F. J., Cherepanin, Ivan M., Polat, Fatih, Burger, Jacobus W. A., Rutten, Harm J. T., Bosker, Robert J. I., Talsma, Koen, Rothbarth, Joost, Verhoef, Cees, van de Ven, Anthony W. H., van der Bilt, Jarmila D. W., de Graaf, Eelco J. R., Doornebosch, Pascal G., Leijtens, Jeroen W. A., Heemskerk, Jeroen, Singh, Baljit, Chaudhri, Sanjay, Gerhards, Michael F., Karsten, Tom M., de Wilt, Johannes H. W., Bremers, Andre J. A., Vuylsteke, Ronald J. C. L. M., Heuff, Gijsbert, van Geloven, Anna A. W., Tanis, Pieter J., and Musters, Gijsbert D.

Published
2020
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11. Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial

Author

Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M. G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L. A. M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, van den Hout, Wilbert B., Langers, Alexandra M. J., van der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y. L., ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., ten Hove, Rogier W. R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J Th, Zimmerman, David D. E., Hadithi, Muhammed, Morreau, Hans, de Cuba, Erienne M. V., Leijtens, Jeroen W. A., Vasen, Hans F. A., van Leerdam, Monique E., de Graaf, Eelco J. R., Doornebosch, Pascal G., and Hardwick, James C. H.

Published
2020
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12. Patient-led home-based follow-up after surgery for colorectal cancer:the protocol of the prospective, multicentre FUTURE-primary implementation study

Author

Voigt, Kelly Raquel, Wullaert, Lissa, Höppener, Diederik J., Schreinemakers, Jennifer M.J., Doornebosch, Pascal G., Verseveld, Maria, Peeters, Koen, Verhoef, Cornelis, Husson, Olga, Grünhagen, Dirk, Voigt, Kelly Raquel, Wullaert, Lissa, Höppener, Diederik J., Schreinemakers, Jennifer M.J., Doornebosch, Pascal G., Verseveld, Maria, Peeters, Koen, Verhoef, Cornelis, Husson, Olga, and Grünhagen, Dirk

Abstract

INTRODUCTION: Colorectal cancer (CRC) is the third most common type of cancer in the Netherlands. Approximately 90% of patients can be treated with surgery, which is considered potentially curative. Postoperative surveillance during the first 5 years after surgery pursues to detect metastases in an early, asymptomatic and treatable stage. Multiple large randomised controlled trials have failed to show any (cancer-specific) survival benefit of intensive postoperative surveillance compared with a minimalistic approach in patients with CRC. This raises the question whether an (intensive) in-hospital postoperative surveillance strategy is still warranted from both a patient well-being and societal perspective. A more modern, home-based surveillance strategy could be beneficial in terms of patients' quality of life and healthcare costs. METHODS AND ANALYSIS: The multicentre, prospective FUTURE-primary study implements a patient-led home-based surveillance after curative CRC treatment. Here, patients are involved in the choice regarding three fundamental aspects of their postoperative surveillance. First regarding frequency, patients can opt for additional follow-up moments to the minimal requirement as outlined by the current Dutch national guidelines. Second regarding the setting, both in-hospital or predominantly home-based options are available. And third, concerning patient-doctor communication choices ranging from in-person to video chat, and even silent check-ups. The aim of the FUTURE-primary study is to evaluate if such a patient-led home-based follow-up approach is successful in terms of quality of life, satisfaction and anxiety compared with historic data. A successful implementation of the patient-led aspect will be assessed by the degree in which the additional, optional follow-up moments are actually utilised. Secondary objectives are to evaluate quality of life, anxiety, fear of cancer recurrence and cost-effectiveness.

Published
2023

13. Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients

Author

Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., Boonstra, Jurjen J., Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., and Boonstra, Jurjen J.

Abstract

T1 colorectal cancers (T1CRC) are increasingly being treated by endoscopic submucosal dissection (ESD). After ESD of a T1CRC, completion surgery is indicated in a subgroup of patients. Currently, the influence of ESD on surgical morbidity and mortality is unknown. The aim of this study was to compare 90-day morbidity and mortality of completion surgery after ESD to primary surgery. The completion surgery group consisted of suspected T1CRC patients from a multicenter prospective ESD database (2014–2020). The primary surgery group consisted of pT1CRC patients from a nationwide surgical registry (2017–2019). Patients with rectal or sigmoidal cancers were selected. Patients receiving neoadjuvant therapy were excluded. Propensity score adjustment was used to correct for confounders. In total, 411 patients were included: 54 in the completion surgery group (39 pT1, 15 pT2) and 357 in the primary surgery group with pT1CRC. Adverse event rate was 24.1% after completion surgery and 21.3% after primary surgery. After completion surgery 90-day mortality did not occur, though one patient died in the primary surgery group. After propensity score adjustment, lymph node yield did not differ significantly between the groups. Among other morbidity-related outcomes, stoma rate (OR 1.298 95%-CI 0.587-2.872, p = 0.519) and adverse event rate (OR 1.162; 95%-CI 0.570-2.370, p = 0.679) also did not differ significantly. A subgroup analysis was performed in patients undergoing rectal surgery. In this subgroup (37 completion and 136 primary surgery), these morbidity outcomes also did not differ significantly. In conclusion, this study suggests that ESD does not compromise morbidity or 90-day mortality of completion surgery.

Published
2023

14. Systemic exposure of floxuridine after hepatic arterial infusion pump chemotherapy with floxuridine in patients with resected colorectal liver metastases

Author

IJzerman, Nikki S, Filipe, Wills F, Bruijn, Peter de, Buisman, Florian E, Doorn, Leni van, Doornebosch, Pascal G, Holster, Jessica J, Grootscholten, Cecile, Grünhagen, Dirk J, van Bommel, Christian P E, Homs, Marjolein Y V, Kok, Niels F M, Verhoef, Cornelis, Koerkamp, Bas Groot, Kuhlmann, Koert F D, Mathijssen, Ron H J, Koolen, Stijn L W, IJzerman, Nikki S, Filipe, Wills F, Bruijn, Peter de, Buisman, Florian E, Doorn, Leni van, Doornebosch, Pascal G, Holster, Jessica J, Grootscholten, Cecile, Grünhagen, Dirk J, van Bommel, Christian P E, Homs, Marjolein Y V, Kok, Niels F M, Verhoef, Cornelis, Koerkamp, Bas Groot, Kuhlmann, Koert F D, Mathijssen, Ron H J, and Koolen, Stijn L W

Abstract

BACKGROUND: Floxuridine's high hepatic extraction ratio and short elimination half-life allows maximum liver exposure with minimal systemic side-effects. This study attempts to quantify the systemic exposure of floxuridine.METHODS: Patients undergoing continuous hepatic arterial infusion pump (HAIP) floxuridine after resection of colorectal liver metastases (CRLM) in two centres underwent six cycles of floxuridine at start dose 0.12 mg/kg/day. No concomitant systemic chemotherapy was administered. Peripheral venous blood samples were drawn during the first two cycles: pre-dose (only in the second cycle), 30 min, 1 h, 2 h, 7 h, and 15 days after floxuridine infusion. Foxuridine concentration in the residual pump reservoir was measured on day 15 of both cycles. A floxuridine assay with a lower boundary of detection of 0.250 ng/mL was developed.RESULTS: 265 blood samples were collected in the 25 patient included in this study. Floxuridine was mostly measurable at day 7 and day 15 (86 % and 88 % of patients respectively). The median dose corrected concentrations were 0.607 ng/mL [IQR: 0.472-0.747] for cycle 1 day 7, 0.579 ng/mL [IQR: 0.470-0.693] for cycle 1 day 15, 0.646 ng/mL [IQR: 0.463-0.8546] for cycle 2 day 7, and 0.534 ng/mL [IQR: 0.4257-0.7075] for cycle 2 day 15. One patient had remarkably high floxuridine concentrations reaching up to 44 ng/mL during the second cycle, without a clear explanation. The floxuridine concentration in the pump decreased by 14.7 % (range 0.5 %-37.8 %) over a period of 15 days (n = 18).CONCLUSION: Overall, negligible systemic concentrations of floxuridine were detected. However, remarkably increased levels were detected in one patient. Floxuridine concentration in the pump decreases over time.

Published
2023

15. GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells

Author

Rakké, Yannick S, Campos Carrascosa, Lucia, van Beek, Adriaan A, de Ruiter, Valeska, van Gemerden, Rachelle S, Doukas, Michail, Doornebosch, Pascal G, Vermaas, Maarten, Ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L O, Kliffen, Mike, Grünhagen, Dirk J, Verhoef, Cornelis, IJzermans, Jan N M, Kwekkeboom, Jaap, Sprengers, Dave, Rakké, Yannick S, Campos Carrascosa, Lucia, van Beek, Adriaan A, de Ruiter, Valeska, van Gemerden, Rachelle S, Doukas, Michail, Doornebosch, Pascal G, Vermaas, Maarten, Ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L O, Kliffen, Mike, Grünhagen, Dirk J, Verhoef, Cornelis, IJzermans, Jan N M, Kwekkeboom, Jaap, and Sprengers, Dave

Abstract

BACKGROUND & AIMS: In contrast to mismatch repair deficient colorectal carcinoma (CRC), MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied immune checkpoint stimulation via glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) on ex vivo functionality of human tumor-infiltrating lymphocytes (TIL) isolated from pMMR primary CRC and liver metastases (CRLM).METHODS: Using lymphocytes from resected tumor, adjacent tissues, and peripheral blood mononuclear cells (PBMC) of 132 pMMR primary CRC or CRLM patients, we determined GITR expression and the in vitro T-cell agonistic activity of recombinant GITR ligation.RESULTS: Here, we show that GITR was overexpressed on TIL when compared with other stimulatory immune checkpoints (4-1BB, OX40). Its expression was enhanced in TIL compared with PBMC and adjacent tissues. Among CD4 + TIL, GITR expression was primarily expressed by CD45RA - FoxP3 hi activated regulatory T cells. Within CD8 + TIL, GITR was predominantly expressed on functionally exhausted and putative tumor-reactive CD103 + CD39 + TIL. Strikingly, recombinant GITRL reinvigorated ex vivo TIL responses by significantly enhancing CD4 + and CD8 + TIL numbers. Dual treatment with GITRL and nivolumab (anti-PD1) enhanced CD8 + TIL expansion compared with GITRL monotherapy. Moreover, GITRL/anti-PD1 dual therapy further improved anti-PD1-mediated reinvigoration of interferon gamma secretion by exhausted CD8 TIL from primary CRC. CONCLUSIONS: GITR is overexpressed on CD4 + and CD8 + TIL from pMMR CRC and CRLM. Agonistic targeting of GITR enhances ex vivo human TIL functionality and may therefore be a promising approach for novel monotherapy or combined immunotherapies in primary pMRR CRC and CRLM.

Published
2023

16. Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients

Author

MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., Boonstra, Jurjen J., MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, Vork, Katinka, Langers, Alexandra M.J., van der Kraan, Jolein, Westerterp, Marinke, Peeters, Koen C.M.J., Holman, Fabian A., Koch, Arjun D., de Graaf, Wilmar, Didden, Paul, Moons, Leon M.G., Doornebosch, Pascal G., Hardwick, James C.H., and Boonstra, Jurjen J.

Published
2023

17. Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression

Author

MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, van der Kraan, Jolein, le Cessie, Saskia, Oldenburg, Philip P, Schoones, Jan W, Langers, Alexandra M J, van Leerdam, Monique E, van Hooft, Jeanin E, Backes, Yara, Levic, Katarina, Meining, Alexander, Saracco, Giorgio M, Holman, Fabian A, Peeters, Koen C M J, Moons, Leon M G, Doornebosch, Pascal G, Hardwick, James C H, Boonstra, Jurjen J, MS MDL 1, Cancer, Dekkers, Nik, Dang, Hao, van der Kraan, Jolein, le Cessie, Saskia, Oldenburg, Philip P, Schoones, Jan W, Langers, Alexandra M J, van Leerdam, Monique E, van Hooft, Jeanin E, Backes, Yara, Levic, Katarina, Meining, Alexander, Saracco, Giorgio M, Holman, Fabian A, Peeters, Koen C M J, Moons, Leon M G, Doornebosch, Pascal G, Hardwick, James C H, and Boonstra, Jurjen J

Published
2022

18. The learning curve of transanal total mesorectal excision for rectal cancer is associated with local recurrence: results from a multicentre external audit:results from a multicentre external audit

Author

van Oostendorp, Stefan E., Belgers, H. J., Hol, Jeroen C., Doornebosch, Pascal G., Belt, Eric J. Th., Oosterling, Steven J., Kusters, Miranda, Bonjer, H. J., Sietses, Colin, Tuynman, Jurriaan B., Boerma, E. J., Creemers, D., Graaf, E. J. De, van der Hoeven, J. A. B., Sosef, M. N., Stockmann, H. B. A. C., van der Stok, E. P., Vuylsteke, R. C. L. M., Surgery, CCA - Cancer Treatment and quality of life, APH - Global Health, APH - Quality of Care, and Amsterdam Gastroenterology Endocrinology Metabolism

Abstract

Aim: Transanal total mesorectal excision (TaTME) has been suggested as a potential solution for the resection of challenging mid and low rectal cancer. This relatively complex procedure has been implemented in many centres over the last years, despite the absence of long-term safety data. Recently, concern has arisen because of an increase in local recurrence in the implementation phase. The aim of this study was to assess the correlation between accumulated experience and local recurrences. Method: An independent clinical researcher performed an external audit of consecutive series of all TaTME procedures in six centres in the Netherlands. Kaplan–Meier estimated local recurrence rates were calculated and multivariate Cox proportional hazards regression analysis performed to assess risk factors for local recurrence. Primary outcome was the local recurrence rate in the initial implementation (cases 1–10), continued adoption (cases 11-40) and prolonged experience (case 41 onward). Results: Six hundred and twenty-four consecutive patients underwent TaTME for rectal cancer with a median follow-up of 27 months (range 1–82 months). The estimated 2- and 3-year local recurrence rates were 4.6% and 6.6%, respectively. Cox proportional hazards regression revealed procedural experience to be an independent factor in multivariate analysis next to advanced stage (ycMRF+, pT3-4, pN+) and pelvic sepsis. Corrected analysis projected the 3-year local recurrence rates to be 9.7%, 3.3% and 3.5% for the implementation, continued adoption and prolonged experience cohorts, respectively. Conclusion: This multicentre study shows a high local recurrence rate (12.5%) after implementation of TaTME which lowers to an acceptable rate (3.4%) when experience increases. Therefore, intensified proctoring and further precautions must be implemented to reduce the unacceptably high risk of local recurrence at units starting this technique.

Published
2021

19. Additional file 1 of Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): study protocol of a European multicenter randomised controlled trial

Author

Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M. G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L. A. M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Hout, Wilbert B. Van Den, Langers, Alexandra M. J., Jolein Van Der Kraan, Alkhalaf, Alaa, Lai, Jonathan Y. L., Borg, Frank Ter, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Hove, Rogier W. R. Ten, Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J Th, Zimmerman, David D. E., Hadithi, Muhammed, Morreau, Hans, Erienne M. V. De Cuba, Leijtens, Jeroen W. A., Vasen, Hans F. A., Leerdam, Monique E. Van, Graaf, Eelco J. R. De, Doornebosch, Pascal G., and Hardwick, James C. H.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
Full Text
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20. Transanal minimally invasive surgery (TAMIS) versus endoscopic submucosal dissection (ESD) for resection of non-pedunculated rectal lesions (TRIASSIC study): Study protocol of a European multicenter randomised controlled trial

Author

MS MDL 1, Cancer, Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M.G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L.A.M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Van Den Hout, Wilbert B., Langers, Alexandra M.J., Van Der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y.L., Ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Ten Hove, Rogier W.R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J.Th, Zimmerman, David D.E., Hadithi, Muhammed, Morreau, Hans, De Cuba, Erienne M.V., Leijtens, Jeroen W.A., Vasen, Hans F.A., Van Leerdam, Monique E., De Graaf, Eelco J.R., Doornebosch, Pascal G., Hardwick, James C.H., MS MDL 1, Cancer, Dekkers, Nik, Boonstra, Jurjen J., Moons, Leon M.G., Hompes, Roel, Bastiaansen, Barbara A., Tuynman, Jurriaan B., Koch, Arjun D., Weusten, Bas L.A.M., Pronk, Apollo, Neijenhuis, Peter A., Westerterp, Marinke, Van Den Hout, Wilbert B., Langers, Alexandra M.J., Van Der Kraan, Jolein, Alkhalaf, Alaa, Lai, Jonathan Y.L., Ter Borg, Frank, Fabry, Hans, Halet, Eric, Schwartz, Matthijs P., Nagengast, Wouter B., Straathof, Jan Willem A., Ten Hove, Rogier W.R., Oterdoom, Leendert H., Hoff, Christiaan, Belt, Eric J.Th, Zimmerman, David D.E., Hadithi, Muhammed, Morreau, Hans, De Cuba, Erienne M.V., Leijtens, Jeroen W.A., Vasen, Hans F.A., Van Leerdam, Monique E., De Graaf, Eelco J.R., Doornebosch, Pascal G., and Hardwick, James C.H.

Published
2020

21. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands

Author

van der Poel, Marcel J., primary, Fichtinger, Robert S., additional, Bemelmans, Marc, additional, Bosscha, Koop, additional, Braat, Andries E., additional, de Boer, Marieke T., additional, Dejong, Cornelis H.C., additional, Doornebosch, Pascal G., additional, Draaisma, Werner A., additional, Gerhards, Michael F., additional, Gobardhan, Paul D., additional, Gorgec, Burak, additional, Hagendoorn, Jeroen, additional, Kazemier, Geert, additional, Klaase, Joost, additional, Leclercq, Wouter K.G., additional, Liem, Mike S., additional, Lips, Daan J., additional, Marsman, Hendrik A., additional, Mieog, J. Sven D., additional, Molenaar, Quintus I., additional, Nieuwenhuijs, Vincent B., additional, Nota, Carolijn L., additional, Patijn, Gijs A., additional, Rijken, Arjen M., additional, Slooter, Gerrit D., additional, Stommel, Martijn W.J., additional, Swijnenburg, Rutger-Jan, additional, Tanis, Pieter J., additional, te Riele, Wouter W., additional, Terkivatan, Türkan, additional, van den Tol, Petrousjka M., additional, van den Boezem, Peter B., additional, van der Hoeven, Joost A., additional, Vermaas, Maarten, additional, Abu Hilal, Moh'd, additional, van Dam, Ronald M., additional, Besselink, Marc G., additional, Zonderhuis, Babs, additional, Rinkes, Inne B., additional, Hoff, Christiaan, additional, and Oosterling, Steven, additional

Published
2019
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22. Transanal Endoscopic Microsurgery with or without Completion Total Mesorectal Excision for T2 and T3 Rectal Carcinoma

Author

Leijtens, J.W.A., Koedam, T.W., Borstlap, Wernard A.A., Maas, Monique, Doornebosch, Pascal G., Karsten, Tom M., Rosman, C., Bremers, A.J.A., Tuynman, J.B., Rademakers, Kevin L.J., Leijtens, J.W.A., Koedam, T.W., Borstlap, Wernard A.A., Maas, Monique, Doornebosch, Pascal G., Karsten, Tom M., Rosman, C., Bremers, A.J.A., Tuynman, J.B., and Rademakers, Kevin L.J.

Abstract

Contains fulltext : 201272.pdf (publisher's version ) (Closed access)

Published
2019

23. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands

Author

van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, Oosterling, Steven, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, and Oosterling, Steven

Published
2019

24. Implementation and outcome of minor and major minimally invasive liver surgery in the Netherlands

Author

MS CGO, Cancer, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, Oosterling, Steven, MS CGO, Cancer, van der Poel, Marcel J., Fichtinger, Robert S., Bemelmans, Marc, Bosscha, Koop, Braat, Andries E., de Boer, Marieke T., Dejong, Cornelis H. C., Doornebosch, Pascal G., Draaisma, Werner A., Gerhards, Michael F., Gobardhan, Paul D., Gorgec, Burak, Hagendoorn, Jeroen, Kazemier, Geert, Klaase, Joost, Leclercq, Wouter K. G., Liem, Mike S., Lips, Daan J., Marsman, Hendrik A., Mieog, J. Sven D., Molenaar, Quintus I., Nieuwenhuijs, Vincent B., Nota, Carolijn L., Patijn, Gijs A., Rijken, Arjen M., Slooter, Gerrit D., Stommel, Martijn W. J., Swijnenburg, Rutger-Jan, Tanis, Pieter J., te Riele, Wouter W., Terkivatan, Turkan, van den Tol, Petrousjka M., van den Boezem, Peter B., van der Hoeven, Joost A., Vermaas, Maarten, Abu Hilal, Moh'd, van Dam, Ronald M., Besselink, Marc G., Zonderhuis, Babs, Rinkes, Inne B., Hoff, Christiaan, and Oosterling, Steven

Published
2019

25. The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery

Author

Bökkerink Guus MJ, de Graaf Eelco JR, Punt Cornelis JA, Nagtegaal Iris D, Rütten Heidi, Nuyttens Joost JME, van Meerten Esther, Doornebosch Pascal G, Tanis Pieter J, Derksen Eric J, Dwarkasing Roy S, Marijnen Corrie AM, Cats Annemieke, Tollenaar Rob AEM, de Hingh Ignace HJT, Rutten Harm JT, van der Schelling George P, ten Tije Albert J, Leijtens Jeroen WA, Lammering Guido, Beets Geerard L, Aufenacker Theo J, Pronk Apollo, Manusama Eric R, Hoff Christiaan, Bremers Andreas JA, Verhoef Cornelelis, and de Wilt Johannes HW

Subjects
Surgery, RD1-811
Abstract

Abstract Background The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. Methods/Design Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine). Transanal Endoscopic Microsurgery (TEM) will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response. Primary objective is to determine the number of patients with a (near) complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol. Discussion The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051)

Published
2011
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26. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)

Author

Geldof Han, Breumelhof Ronald, Mallant-Hent Rosalie CH, Jansen Jeroen M, van der Linde Klaas, Heine G Dimitri N, van Dullemen Hendrik M, Hoff Christiaan, Davids Paul HP, Bijnen A Bart, Derksen Erik J, Boom Maarten J, Schwartz Matthijs P, Consten Esther CJ, Gerhards Michael F, Weusten Bas LAM, Timmer Robin, Haringsma Jelle, Reitsma Johannes B, Dijkgraaf Marcel GW, de Graaf Eelco JR, van den Broek Frank JC, Hardwick James CH, Doornebosch Pascal G, Depla Annekatrien CTM, Ernst Miranda F, van Munster Ivo P, de Hingh Ignace HJT, Schoon Erik J, Bemelman Willem A, Fockens Paul, and Dekker Evelien

Subjects
Surgery, RD1-811
Abstract

Abstract Background Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM). If equally effective, EMR might be a more cost-effective approach as this strategy does not require expensive equipment, general anesthesia and hospital admission. Furthermore, EMR appears to be associated with fewer complications. The aim of this study is to compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas. Methods/design Multicenter randomized trial among 15 hospitals in the Netherlands. Patients with a rectal adenoma ≥ 3 cm, located between 1–15 cm ab ano, will be randomized to a TEM- or EMR-treatment strategy. For TEM, patients will be treated under general anesthesia, adenomas will be dissected en-bloc by a full-thickness excision, and patients will be admitted to the hospital. For EMR, no or conscious sedation is used, lesions will be resected through the submucosal plane in a piecemeal fashion, and patients will be discharged from the hospital. Residual adenoma that is visible during the first surveillance endoscopy at 3 months will be removed endoscopically in both treatment strategies and is considered as part of the primary treatment. Primary outcome measure is the proportion of patients with recurrence after 3 months. Secondary outcome measures are: 2) number of days not spent in hospital from initial treatment until 2 years afterwards; 3) major and minor morbidity; 4) disease specific and general quality of life; 5) anorectal function; 6) health care utilization and costs. A cost-effectiveness and cost-utility analysis of EMR against TEM for large rectal adenomas will be performed from a societal perspective with respectively the costs per recurrence free patient and the cost per quality adjusted life year as outcome measures. Based on comparable recurrence rates for TEM and EMR of 3.3% and considering an upper-limit of 10% for EMR to be non-inferior (beta-error 0.2 and one-sided alpha-error 0.05), 89 patients are needed per group. Discussion The TREND study is the first randomized trial evaluating whether TEM or EMR is more cost-effective for the treatment of large rectal adenomas. Trial registration number (trialregister.nl) NTR1422

Published
2009
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27. Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures

Author

McCormack, Robert, Apostle, Kelly, Moon, Raely, Bielby, Shea A., Switzer, Julie A., Cole, Peter A., Anderson, Sarah A., Lafferty, Paul M., Li, Mengnai, Ly, Thuan V., Marston, Scott B., Foley, Amy L., Vang, Sandy, Oatt, Amber, Wright, David M., Marcantonio, Andrew J., Kain, Michael S. H., Iorio, Richard, Specht, Lawrence M., Tilzey, John F., Lobo, Margaret J., Garfi, John S., Vallier, Heather A., Dolenc, Andrea, Buckley, Richard E., Robinson, Chalitha, Prayson, Michael J., Laughlin, Richard, Rubino, L. Joseph, May, Jedediah, Rieser, Geoffrey Ryan, Dulaney-Cripe, Liz, Gayton, Chris, Shaer, James, Schrickel, Tyson, Duffy, Paul, Hileman, Barbara, Gorczyca, John T., Gross, Jonathan M., Humphrey, Catherine A., Kates, Stephen, Noble, Krista, McIntyre, Allison W., Pecorella, Kaili, Davis, Craig A., Weinerman, Stewart, Korley, Robert, Weingarten, Peter, Stull, Philip, Lindenbaum, Stephen, Hewitt, Michael, Schwappach, John, Baker, Janell K., Rutherford, Tori, Newman, Heike, Lieberman, Shane, Finn, Erin, Puloski, Shannon, Robbins, Kristin, Hurley, Meghan, Lyle, Lindsey, Mitchell, Khalis, Browner, Kieran, Whatley, Erica, Payton, Krystal, Reeves, Christina, Cannada, Lisa K., Karges, David, Johnston, Kelly, Hill, Leslie, Mehta, Samir, Esterhai, John, Ahn, Jaimo, Horan, Annamarie D., McGinnis, Kelly, Kaminski, Christine A., Kowalski, Brynn N., Keeve, Jonathan P., Anderson, Christopher G., Powell, James, McDonald, Michael D., Hoffman, Jodi M., Tarkin, Ivan, Siska, Peter, Gruen, Gary, Evans, Andrew, Farrell, Dana J., Irrgang, James, Luther, Arlene, Cross III., William W., Carcary, Kimberly, Cass, Joseph R., Sems, Stephen A., Torchia, Michael E., Scrabeck, Tyson, Jenkins, Mark, Dumais, Jules, Romero, Amanda W., Sagebien, Carlos A., Butler, Mark S., Monica, James T., Sanders, David, Seuffert, Patricia, Hsu, Joseph R., Ficke, James, Charlton, Michael, Napierala, Matthew, Fan, Mary, Tornetta III., Paul, Tannoury, Chadi, Carlisle, Hope, Silva, Heather, Boyer, Dory, Lawendy, Abdel, Archdeacon, Michael, Finnan, Ryan, Le, Toan, Wyrick, John, Hess, Shelley, Brennan, Michael L., Probe, Robert, Kile, Evelyn, Mills, Kelli, Clipper, Lydia, Tieszer, Christina, Yu, Michelle, Erwin, Katie, Horwitz, Daniel, Strohecker, Kent, Swenson, Teresa K., Aurang, Kamran, Zohman, Gary, Peterson, Brett, Huff, Roger B., Baele, Joseph, Stephen, David, Weber, Timothy, Edison, Matt, McBeth, Jessica, Shively, Karl, Ertl, Janos P., Mullis, Brian, Parr, J. Andrew, Worman, Ripley, Frizzell, Valda, Moore, Molly M., Kreder, Hans, Tobias, Erin, Thomas, Emily, DePaolo, Charles J., Alosky, Rachel, Shell, Leslie E., Hampton, Lynne, Shepard, Stephanie, Nanney, Tracy, Cuento, Claudine, Cantu, Robert V., Jenkinson, Richard, Henderson, Eric R., Eickhoff, Linda S., Hammerberg, E. Mark, Stahel, Philip, Hak, David, Mauffrey, Cyril, Gibula, Douglas, Gissel, Hannah, Henderson, Corey, Zamorano, David P., Nousiainen, Markku, Tynan, Martin C., Pourmand, Deeba, Lawson, Deanna, Della Rocca, Gregory J., Crist, Brett D., Murtha, Yvonne M., Anderson, Linda K., Linehan, Colleen, Pilling, Lindsey, Lewis, Courtland G., Axelrod, Terry, Caminiti, Stephanie, Sullivan, Raymond J., Roper, Elizabeth, Obremskey, William, Kregor, Philip, Richards, Justin E., Stringfellow, Kenya, Dohm, Michael P., Zellar, Abby, Segers, Michiel J. M., Murnaghan, John, Zijl, Jacco A. C., Verhoeven, Bart, Smits, Anke B., de Vries, Jean Paul P. M., Fioole, Bram, van der Hoeven, Henk, Theunissen, Evert B. M., de Vries Reilingh, Tammo S., Govaert, Lonneke, Wittich, Philippe, Nam, Diane, de Brauw, Maurits, Wille, Jan, Go, Peter M. N. Y. M., Ritchie, Ewan D., Wessel, Ronald N., Hammacher, Eric R., Heetveld, Martin J., Visser, Gijs A., Stockmann, Heyn, Silvis, Rob, Wadey, Veronica, Snellen, Jaap P., Rijbroek, Bram, Scheepers, Joris J. G., Vermeulen, Erik G. J., Siroen, Michiel P. C., Vuylsteke, Ronald, Brom, Hans L. F., Rijna, Herman, de Rijcke, Piet A. R., Koppert, Cees L., Moola, Farhad, Yee, Albert, Buijk, Steven E., Groenendijk, Richard P. R., Dawson, Imro, Tetteroo, Geert W. M., Bruijninckx, Milko M. M., Doornebosch, Pascal G., de Graaf, Eelco J. R., van der Elst, Maarten, van der Pol, Carmen C., van 't Riet, Martijne, Milner, Katrine, Karsten, Tom M., de Vries, Mark R., Stassen, Laurents P. S., Schep, Niels W. L., Schmidt, G. Ben, Hoffman, W. H., Poolman, Rudolf W., Simons, Maarten P., van der Heijden, Frank H. W. M., Willems, W. Jaap, Kunz, Monica, de Meulemeester, Frank R. A. J., van der Hart, Cor P., Turckan, Kahn, Festen, Sebastiaan, de Nies, Frank, Haverlag, Robert, Out, Nico J. M., Bosma, Jan, van Kampen, Albert, Biert, Jan, Schemitsch, Emil H., van Vugt, Arie B., Edwards, Michael J. R., Blokhuis, Taco J., Frolke, Jan Paul M., Geeraedts, Leo M. G., Gardeniers, Jean W. M., Tan, Edward T. C. H., Poelhekke, Lodewijk M. S. J., de Waal Malefijt, Maarten C., Schreurs, Bart, Ahn, Henry, Roukema, Gert R., Josaputra, Hong A., Keller, Paul, de Rooij, Peter D., Kuiken, Hans, Boxma, Han, Cleffken, Berry I., Liem, Ronald, Rhemrev, Steven J., Bosman, Coks H. R., Hall, Jeremy A., de Mol van Otterloo, Alexander, Hoogendoorn, Jochem, de Vries, Alexander C., Meylaerts, Sven A. G., Verhofstad, Michiel H. J., Meijer, Joost, van Egmond, Teun, van der Brand, Igor, Patka, Peter, McKee, Michael D., Eversdijk, Martin G., Peters, Rolf, Den Hartog, Dennis, Van Waes, Oscar J. F., Oprel, Pim, van der Vis, Harm M., Campo, Martin, Verhagen, Ronald, Albers, G. H. Robert, Zurcher, Arthur W., Whelan, Daniel B., Simmermacher, Rogier K. J., van Mulken, Jeroen, van Wessem, Karlijn, van Gaalen, Steven M., Leenen, Luke, Bronkhorst, Maarten W. G. A., Guicherit, Onno R., Goslings, J. Carel, Nauth, Aaron, Ponsen, Kees Jan, Bhatia, Mahesh, Arora, Vinod, Tyagi, Vivek, Liew, Susan, Bedi, Harvinder, Carr, Ashley, Curry, Hamish, Chia, Andrew, Csongvay, Steve, Vicente, Milena R., Donohue, Craig, Doig, Stephen, Edwards, Elton, Etherington, Greg, Esser, Max, Gong, Andrew, Jain, Arvind, Li, Doug, Miller, Russell, Moaveni, Ash, Perey, Bertrand, Wild, Lisa M., Russ, Matthias, Ton, Lu, Wang, Otis, Dowrick, Adam, Murdoch, Zoe, Sage, Claire, Frihagen, Frede, Clarke-Jenssen, John, Hjorthaug, Geir, Ianssen, Torben, Khan, Ryan M., Amundsen, Asgeir, Brattgjerd, Jan Egil, Borch, Tor, Boe, Berthe, Flatoy, Bernhard, Hasselund, Sondre, Haug, Knut Jorgen, Hemlock, Kim, Hoseth, Tor Magne, Jomaas, Geir, Hidy, Jennifer T., Kibsgard, Thomas, Lona, Tarjei, Moatshe, Gilbert, Muller, Oliver, Molund, Marius, Nicolaisen, Tor, Nilsen, Fredrik, Rydinge, Jonas, Smedsrud, Morten, Stodle, Are, Coles, Chad, Trommer, Axel, Ugland, Stein, Karlsten, Anders, Ekas, Guri, Vesterhus, Elise Berg, Brekke, Anne Christine, Gupta, Ajay, Jain, Neeraj, Khan, Farah, Sharma, Ateet, Leighton, Ross, Sanghavi, Amir, Trivedi, Mittal, Rai, Anil, Subash, Rai, Kamal, Yadav, Vineet, Singh, Sanjay, Tetsworth, Kevin, Donald, Geoff, Biddulph, Michael, Weinrauch, Patrick, Pincus, Paul, Yang, Steven, Halliday, Brett, Gervais, Trevor, Holt, Michael, Flynn, Annette, Prasad, Amal Shankar, Mishra, Vimlesh, Sundaresh, D. C., Johnston, David, Khanna, Angshuman, Cherian, Joe Joseph, Olakkengil, Davy J., Sharma, Gaurav, Pirpiris, Marinis, Love, David, Bucknill, Andrew, Farrugia, Richard J., Pape, Hans-Christoph, Knobe, Matthias, Glazebrook, Mark, Pfeifer, Roman, Hull, Peter, Lewis, Sophie, Evans, Simone, Nanda, Rajesh, Logishetty, Rajanikanth, Anand, Sanjeev, Bowler, Carol, Dadi, Akhil, Palla, Naveen, Alexander, David, Ganguly, Utsav, Rai, B. Sachidananda, Rajakumar, Janakiraman, Jennings, Andrew, Chuter, Graham, Rose, Glynis, Horner, Gillian, Clark, Callum, Eke, Kate, Reed, Mike, Coady, Cathy, Herriott, Chris, Dobb, Christine, Bhandari, Mohit, Swiontkowski, Marc, Devereaux, Pj, Jeray, Kyle, Thabane, Lehana, Stone, Trevor, Dunbar, Michael, Walter, Stephen, Sprague, Sheila, Scott, Taryn, Guyatt, Gordon, Amirault, David, Viveiros, Helena, McKay, Paula, Swinton, Marilyn, Gross, Michael, Truong, Victoria, Koo, Kaitlin, Heels-Ansdell, Diane, Zhou, Qi, Buckingham, Lisa, Duraikannan, Aravin, Maddock, Deborah, Simunovic, Nicole, Agel, Julie, Oxner, William, Van Lieshout, Esther M. M., Zielinski, Stephanie M., Rangan, Amar, Hanusch, Birgit C., Kottam, Lucksy, Clarkson, Rachel, Reardon, Gerald, Slobogean, Gerard, Katz, Jeffrey, Gillespie, Brenda, Greendale, Gail A., Guy, Pierre, Hartman, Curtis, Rubin, Craig, Waddell, James, FAITH Investigators, Richardson, Glen, Trenholm, Andrew, Wong, Ivan, Trask, Kelly, MacDonald, Shelley, Viskontas, Darius, Dobbin, Gwen, Bicknell, Ryan, Yach, Jeff, Bardana, Davide, Wood, Gavin, Harrison, Mark, Yen, David, Lambert, Sue, Howells, Fiona, Ward, Angela, Lemke, H. Michael, Zalzal, Paul, Brien, Heather, Naumetz, V., Weening, Brad, Wai, Eugene K., Papp, Steve, Gofton, Wade T., Liew, Allen, Kingwell, Stephen P., Zomar, Mauri, Johnson, Garth, O'Neil, Joseph, Roffey, Darren M., Borsella, Vivian, Avram, Victoria, Oliver, Todd M., Jones, Vicki, Jones, Clifford B., Ringler, James R., Endres, Terrence J., Moon, Karyn, Sietsema, Debra L., Jeray, Kyle J., Broderick, J. Scott, Goetz, David R., Pace, Thomas B., Schaller, Thomas M., Porter, Scott E., Tanner, Stephanie L., Snider, Rebecca G., Nastoff, Lauren A., Surgery, Emergency Medicine, Obstetrics and Gynaecology, Other Research, Other departments, Graduate School, and AMS - Amsterdam Movement Sciences

Subjects
Time Factors, Sports medicine, medicine.medical_treatment, Bone Screws, Dentistry, Femoral Neck Fractures, law.invention, Fracture Fixation, Internal, Study Protocol, Postoperative Complications, 0302 clinical medicine, Clinical Protocols, Randomized controlled trial, law, Fracture fixation, Orthopedics and Sports Medicine, 030212 general & internal medicine, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Likelihood Functions, 030222 orthopedics, Femoral neck fractures, 3. Good health, Europe, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Treatment Outcome, Research Design, Hip fractures, Sliding hip screw, Reoperation, medicine.medical_specialty, Asia, Prosthesis Design, 03 medical and health sciences, Fixation (surgical), Rheumatology, medicine, Humans, Internal fixation, Proportional Hazards Models, business.industry, Australia, Arthroplasty, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], North America, Orthopedic surgery, Quality of Life, Cancellous screws, business
Abstract

Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events. FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test. This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials. The FAITH trial is registered at ClinicalTrials.gov (Identifier NCT00761813 ).

Published
2014

28. The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery

Author

Bökkerink, Guus M.J., De Graaf, Eelco J.R., Punt, Cornelis J.A., Nagtegaal, Iris D., Rütten, Heidi, Nuyttens, Joost J.M.E., Van Meerten, Esther, Doornebosch, Pascal G., Tanis, Pieter J., Derksen, Eric J., Dwarkasing, Roy S., Marijnen, Corrie A.M., Cats, Annemieke, Tollenaar, Rob A.E.M., De Hingh, Ignace H.J.T., Rutten, Harm J.T., Van Der Schelling, George P., Ten Tije, Albert J., Leijtens, Jeroen W.A., Lammering, Guido, Beets, Geerard L., Aufenacker, Theo J., Pronk, Apollo, Manusama, Eric R., Hoff, Christiaan, Bremers, Andreas J.A., Verhoef, Cornelelis, De Wilt, Johannes H.W., Bökkerink, Guus M.J., De Graaf, Eelco J.R., Punt, Cornelis J.A., Nagtegaal, Iris D., Rütten, Heidi, Nuyttens, Joost J.M.E., Van Meerten, Esther, Doornebosch, Pascal G., Tanis, Pieter J., Derksen, Eric J., Dwarkasing, Roy S., Marijnen, Corrie A.M., Cats, Annemieke, Tollenaar, Rob A.E.M., De Hingh, Ignace H.J.T., Rutten, Harm J.T., Van Der Schelling, George P., Ten Tije, Albert J., Leijtens, Jeroen W.A., Lammering, Guido, Beets, Geerard L., Aufenacker, Theo J., Pronk, Apollo, Manusama, Eric R., Hoff, Christiaan, Bremers, Andreas J.A., Verhoef, Cornelelis, and De Wilt, Johannes H.W.

Abstract

Background: The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. Methods/Design. Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine). Transanal Endoscopic Microsurgery (TEM) will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response. Primary objective is to determine the number of patients with a (near) complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol. Discussion. The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051).

Published
2011

31. Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)

Author

van den Broek, Frank JC, primary, de Graaf, Eelco JR, additional, Dijkgraaf, Marcel GW, additional, Reitsma, Johannes B, additional, Haringsma, Jelle, additional, Timmer, Robin, additional, Weusten, Bas LAM, additional, Gerhards, Michael F, additional, Consten, Esther CJ, additional, Schwartz, Matthijs P, additional, Boom, Maarten J, additional, Derksen, Erik J, additional, Bijnen, A Bart, additional, Davids, Paul HP, additional, Hoff, Christiaan, additional, van Dullemen, Hendrik M, additional, Heine, G Dimitri N, additional, van der Linde, Klaas, additional, Jansen, Jeroen M, additional, Mallant-Hent, Rosalie CH, additional, Breumelhof, Ronald, additional, Geldof, Han, additional, Hardwick, James CH, additional, Doornebosch, Pascal G, additional, Depla, Annekatrien CTM, additional, Ernst, Miranda F, additional, van Munster, Ivo P, additional, de Hingh, Ignace HJT, additional, Schoon, Erik J, additional, Bemelman, Willem A, additional, Fockens, Paul, additional, and Dekker, Evelien, additional

Published
2009
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32. Progression and Tumor Heterogeneity Analysis in Early Rectal Cancer

Author

Lips, Esther H., primary, van Eijk, Ronald, additional, de Graaf, Eelco J.R., additional, Doornebosch, Pascal G., additional, de Miranda, Noel F.C.C., additional, Oosting, Jan, additional, Karsten, Tom, additional, Eilers, Paul H.C., additional, Tollenaar, Rob A.E.M., additional, van Wezel, Tom, additional, and Morreau, Hans, additional

Published
2008
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33. T1 colorectal cancer patients' perspective on information provision and therapeutic decision-making after local resection.

Author

Dekkers N, Dang H, de Graaf M, Nobbenhuis K, Verhoeven DA, van der Kraan J, de Vos Tot Nederveen Cappel WH, Alkhalaf A, van Westreenen HL, Basiliya K, Peeters KCMJ, Westerterp M, Doornebosch PG, Hardwick JCH, Langers AMJ, and Boonstra JJ

Abstract

Background: Decision-making after local resection of T1 colorectal cancer (T1CRC) is often complex and calls for optimal information provision as well as active patient involvement., Objective: The aim was to evaluate the perceptions of patients with T1CRC on information provision and therapeutic decision-making., Methods: This multicenter cross-sectional study included patients who underwent endoscopic or local surgical resection as initial treatment. Information provision was assessed using the EORTC QLQ-INFO25 questionnaire. In patients with high-risk T1CRC, we evaluated decisional involvement and satisfaction regarding the choice as to whether to undergo additional treatment after local resection, and the level of decisional conflict using the Decisional Conflict Scale., Results: Ninety-eight patients with T1CRC were included (72% response rate; 79/98 endoscopic and 19/98 local surgical resection; 45/98 high-risk T1CRC). Median time since local resection was 28 months (IQR 18); none had developed recurrence. Unmet information needs were reported by 29 patients (30%; 18 low-risk, 11 high-risk), mostly on post-treatment related topics (follow-up visits, recovery time, recurrence prevention). After local resection, 24 of the 45 high-risk patients (53%) underwent additional treatment, while others were subjected to surveillance. Higher-educated patients were more often actively involved in decision-making (93% vs. 43%, p = 0.002) and more frequently underwent additional treatment (79% vs. 40%, p = 0.02). Decisional conflict (p = 0.19) and satisfaction (p = 0.78) were comparable between higher- and lower-educated high-risk patients., Conclusion: Greater attention should be given to the post-treatment course during consultations following local T1CRC resection. The differences in decisional involvement and selected management strategies between higher- and lower-educated high-risk patients warrant further investigation., (© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.)

Published
2024
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