Search

Your search keyword '"Djikeng, Appolinaire"' showing total 293 results
Start Over Author "Djikeng, Appolinaire" Search Limiters Available in Library Collection
293 results on '"Djikeng, Appolinaire"'

1. Bridging the gap in African biodiversity genomics and bioinformatics

Author

Sharaf, Abdoallah, Ndiribe, Charlotte C., Omotoriogun, Taiwo Crossby, Abueg, Linelle, Badaoui, Bouabid, Badiane Markey, Fatu J., Beedessee, Girish, Diouf, Diaga, Duru, Vincent C., Ebuzome, Chukwuike, Eziuzor, Samuel C., Jaufeerally Fakim, Yasmina, Formenti, Giulio, Ghanmi, Nidhal, Guerfali, Fatma Zahra, Houaga, Isidore, Ideozu, Justin Eze, Katee, Sally Mueni, Khayi, Slimane, Kuja, Josiah O., Kwon-Ndung, Emmanuel Hala, Marks, Rose A., Moila, Acclaim M., Mungloo-Dilmohamud, Zahra, Muzemil, Sadik, Nigussie, Helen, Osuji, Julian O., Ras, Verena, Tchiechoua, Yves H., Zoclanclounon, Yedomon Ange Bovys, Tolley, Krystal A., Ziyomo, Cathrine, Mapholi, Ntanganedzeni, Muigai, Anne W. T., Djikeng, Appolinaire, and Ebenezer, ThankGod Echezona

Published
2023
Full Text
View/download PDF

5. Africa: sequence 100,000 species to safeguard biodiversity

Author

Ebenezer, ThankGod Echezona, Muigai, Anne W. T., Nouala, Simplice, Badaoui, Bouabid, Blaxter, Mark, Buddie, Alan G., Jarvis, Erich D., Korlach, Jonas, Kuja, Josiah O., Lewin, Harris A., Majewska, Roksana, Mapholi, Ntanganedzeni, Maslamoney, Suresh, Mbo’o-Tchouawou, Michèle, Osuji, Julian O., Seehausen, Ole, Shorinola, Oluwaseyi, Tiambo, Christian Keambou, Mulder, Nicola, Ziyomo, Cathrine, and Djikeng, Appolinaire

Published
2022
Full Text
View/download PDF

6. Assessment of genotyping array performance for genome-wide association studies and imputation in African cattle

Author

Riggio, Valentina, Tijjani, Abdulfatai, Callaby, Rebecca, Talenti, Andrea, Wragg, David, Obishakin, Emmanuel T., Ezeasor, Chukwunonso, Jongejan, Frans, Ogo, Ndudim I., Aboagye-Antwi, Fred, Toure, Alassane, Nzalawahej, Jahashi, Diallo, Boubacar, Missohou, Ayao, Belem, Adrien M. G., Djikeng, Appolinaire, Juleff, Nick, Fourie, Josephus, Labuschagne, Michel, Madder, Maxime, Marshall, Karen, Prendergast, James G. D., and Morrison, Liam J.

Published
2022
Full Text
View/download PDF

7. Vector abundance and associated abiotic factors that influence the distribution of ticks in six provinces of South Africa.

Author

Makwarela, Tsireledzo G., Djikeng, Appolinaire, Masebe, Tracy M., Nkululeko, Nyangiwe, Nesengani, Lucky T., and Mapholi, Ntanganedzeni O.

Abstract

Background and Aim: Climatic conditions significantly impact the life stages and distribution patterns of ticks and tickborne diseases. South Africa's central plateau and various biomes offer a distinct landscape for studying the geography's effects. The study estimated tick species prevalence and the influential factors on their survival. Materials and Methods: Ticks were gathered from communal cattle in South African provinces including Limpopo (LP), Gauteng (GP), Mpumalanga (MP), KwaZulu-Natal (KZN), the Eastern Cape (EC), and the Free State (FS), from September 2020 to November 2022. Using data from South African weathercasts, the annual climate was assessed. Results: A total of 3,409 ticks were collected, with the highest infestation observed in KZN (45%), followed by LP (26%), EC (19%), GP (5%), MP (2%), and the FS (2%). The most prevalent tick species were Amblyomma hebraeum (55.1%), Rhipicephalus evertsi evertsi (13.9%) and Rhipicephalus (Boophilus), and decoloratus (11.9%). Other species included R. (Boophilus) microplus (10.85%), Hyalomma marginatum (4.8%), Rhipicephalus appendiculatus (1.4%), Harpalus rufipes (0.8%), Rhipicephalus exophthalmos (0.2%), Rhipicephalus glabroscutatus (0.2%), Rhipicephalus sanguineus (0.2%), Haemaphysalis silacea (0.5%), Ixodes pilosus (0.1%), and Rhipicephalus simus (0.1%). The infestations were most prevalent on farms in Pongola and KZN. The temperature fluctuated between 12°C and 35°C during data gathering, while humidity varied between 40% and 65%. Conclusion: This study showed that ticks survive optimally in warm temperatures and high humidity conditions. Livestock farms with high tick infestations may be associated with several risk factors. These practices could involve suboptimal grazing, insufficient acaricidal treatment, and detrimental effects resulting from traditional animal husbandry. Future research is needed to longitudinally evaluate the effects of climate change on tick populations, pathogen transmission, hosts, habitats, and human behavior, influencing potential exposure risks. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Comparative Genomics of Trypanosomatid Parasitic Protozoa

Author

El-Sayed, Najib M., Myler, Peter J., Blandin, Gaëlle, Berriman, Matthew, Crabtree, Jonathan, Aggarwal, Gautam, Caler, Elisabet, Renauld, Hubert, Worthey, Elizabeth A., Hertz-Fowler, Christiane, Ghedin, Elodie, Peacock, Christopher, Bartholomeu, Daniella C., Haas, Brian J., Tran, Anh-Nhi, Wortman, Jennifer R., Angiuoli, Samuel, Anupama, Atashi, Badger, Jonathan, Bringaud, Frederic, Cadag, Eithon, Carlton, Jane M., Cerqueira, Gustavo C., Creasy, Todd, Delcher, Arthur L., Djikeng, Appolinaire, Embley, T. Martin, Hauser, Christopher, Ivens, Alasdair C., Kummerfeld, Sarah K., Pereira-Leal, Jose B., Nilsson, Daniel, Peterson, Jeremy, Salzberg, Steven L., Shallom, Joshua, Silva, Joana C., Sundaram, Jaideep, Westenberger, Scott, White, Owen, Melville, Sara E., Donelson, John E., Andersson, Björn, Stuart, Kenneth D., and Hall, Neil

Published
2005

12. The Genome of the African Trypanosome Trypanosoma brucei

Author

Berriman, Matthew, Ghedin, Elodie, Hertz-Fowler, Christiane, Blandin, Gaëlle, Renauld, Hubert, Bartholomeu, Daniella C., Lennard, Nicola J., Caler, Elisabet, Hamlin, Nancy E., Haas, Brian, Böhme, Ulrike, Hannick, Linda, Aslett, Martin A., Shallom, Joshua, Marcello, Lucio, Hou, Lihua, Wickstead, Bill, Arrowsmith, Claire, Atkin, Rebecca J., Barron, Andrew J., Bringaud, Frederic, Brooks, Karen, Carrington, Mark, Cherevach, Inna, Chillingworth, Tracey-Jane, Churcher, Carol, Clark, Louise N., Corton, Craig H., Cronin, Ann, Davies, Rob M., Doggett, Jonathon, Djikeng, Appolinaire, Feldblyum, Tamara, Field, Mark C., Fraser, Audrey, Goodhead, Ian, Hance, Zahra, Harper, David, Harris, Barbara R., Hauser, Heidi, Hostetler, Jessica, Ivens, Al, Jagels, Kay, Johnson, David, Johnson, Justin, Jones, Kristine, Kerhornou, Arnaud X., Koo, Hean, Larke, Natasha, Landfear, Scott, Larkin, Christopher, Leech, Vanessa, Line, Alexandra, Lord, Angela, MacLeod, Annette, Mooney, Paul J., Moule, Sharon, Morgan, Gareth W., Mungall, Karen, Norbertczak, Halina, Ormond, Doug, Pai, Grace, Peacock, Chris S., Peterson, Jeremy, Quail, Michael A., Rabbinowitsch, Ester, Rajandream, Marie-Adele, Reitter, Chris, Salzberg, Steven L., Sanders, Mandy, Schobel, Seth, Sharp, Sarah, Simmonds, Mark, Simpson, Anjana J., Tallon, Luke, Tait, Andrew, Tivey, Adrian R., Van Aken, Susan, Walker, Danielle, Wanless, David, Wang, Shiliang, White, Brian, White, Owen, Whitehead, Sally, Woodward, John, Wortman, Jennifer, Adams, Mark D., Embley, T. Martin, Gull, Keith, Ullu, Elisabetta, Barry, J. David, Fairlamb, Alan H., Opperdoes, Fred, Barrell, Barclay G., Donelson, John E., Hall, Neil, Fraser, Claire M., Melville, Sara E., and El-Sayed, Najib M.

Published
2005

15. Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Author

Dutta, Prasun, Talenti, Andrea, Young, Rachel, Jayaraman, Siddharth, Callaby, Rebecca, Jadhav, Santosh Kumar, Dhanikachalam, Velu, Manikandan, Mayakannan, Biswa, Bhim B., Low, Wai Y., Williams, John L., Cook, Elizabeth, Toye, Phil, Wall, Eileen, Djikeng, Appolinaire, Marshall, Karen, Archibald, Alan L., Gokhale, Suresh, Kumar, Satish, Hume, David A., and Prendergast, James G. D.

Published
2020
Full Text
View/download PDF

19. The Bovine Pangenome Consortium: democratizing production and accessibility of genome assemblies for global cattle breeds and other bovine species

Author

Smith, Timothy P.L., Bickhart, Derek M., Boichard, Didier A, Chamberlain, Amanda, Djikeng, Appolinaire, Jiang, Yu, Low, Wai Yee, Pausch, Hubert, Demyda‑Peyrás, Sebastian, Prendergast, James, Schnabel, Robert D, and Rosen, Benjamin D.

Subjects
Genome, Animals, Genomics, Cattle/genetics, Polymorphism, Single Nucleotide
Abstract

The Bovine Pangenome Consortium (BPC) is an international collaboration dedicated to the assembly of cattle genomes to develop a more complete representation of cattle genomic diversity. The goal of the BPC is to provide genome assemblies and a community-agreed pangenome representation to replace breed-specific reference assemblies for cattle genomics. The BPC invites partners sharing our vision to participate in the production of these assemblies and the development of a common, community-approved, pangenome reference as a public resource for the research community ( https://bovinepangenome.github.io/ ). This community-driven resource will provide the context for comparison between studies and the future foundation for cattle genomic selection.

Published
2023

20. Livestock phenomics and genetic evaluation approaches in Africa: current state and future perspectives

Author

Houaga, Isidore, Mrode, Raphael, Opoola, Oluyinka, Chagunda, Mizeck G. G., Mwai, Okeyo A., Rege, John E. O., Olori, Victor E., Nash, Oyekanmi, Banga, Cuthbert B., Okeno, Tobias O., and Djikeng, Appolinaire

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

The African livestock sector plays a key role in improving the livelihoods of people through the supply of food, improved nutrition and consequently health. However, its impact on the economy of the people and contribution to national GDP is highly variable and generally below its potential. This study was conducted to assess the current state of livestock phenomics and genetic evaluation methods being used across the continent, the main challenges, and to demonstrate the effects of various genetic models on the accuracy and rate of genetic gain that could be achieved. An online survey of livestock experts, academics, scientists, national focal points for animal genetic resources, policymakers, extension agents and animal breeding industry was conducted in 38 African countries. The results revealed 1) limited national livestock identification and data recording systems, 2) limited data on livestock production and health traits and genomic information, 3) mass selection was the common method used for genetic improvement with very limited application of genetic and genomic-based selection and evaluation, 4) limited human capacity, infrastructure, and funding for livestock genetic improvement programmes, as well as enabling animal breeding policies. A joint genetic evaluation of Holstein-Friesian using pooled data from Kenya and South Africa was piloted. The pilot analysis yielded higher accuracy of prediction of breeding values, pointing to possibility of higher genetic gains that could be achieved and demonstrating the potential power of multi-country evaluations: Kenya benefited on the 305-days milk yield and the age at first calving and South Africa on the age at first calving and the first calving interval. The findings from this study will help in developing harmonized protocols for animal identification, livestock data recording, and genetic evaluations (both national and across-countries) as well as in designing subsequent capacity building and training programmes for animal breeders and livestock farmers in Africa. National governments need to put in place enabling policies, the necessary infrastructure and funding for national and across country collaborations for a joint genetic evaluation which will revolutionize the livestock genetic improvement in Africa.

Published
2023

21. Open Institute of the African BioGenome Project: Bridging the gap in African biodiversity genomics and bioinformatics

Author

Sharaf, Abdoallah, Ndiribe, Charlotte C., Omotoriogun, Taiwo Crossby, Abueg, Linelle, Badaou, Bouabid, Markey, Fatu J. Badiane, Beedessee, Girish, Diouf, Diaga, Duru, Vincent C., Ebuzome, Chukwuike, Eziuzo, Samuel C., Jaufeerally Fakim, Yasmina, Formenti, Giulio, Ghanm, Nidhal, Guerfali, Fatma Zahra, Houaga, Isidore, Ideozu, Justin Eze, Katee, Sally Mueni, Khayi, Slimane, Kuja, Josiah O., Kwon-Ndung, Emmanuel Hala, Marks, Rose A., Moila, Acclaim M., Mungloo-Dilmohamud, Zahra, Muzemi, Sadik, Negussie, Helen, Osuji, Julian O., Ras, Verena, Tchiechoua, Yves H., Zoclanclounon, Yedomon Ange Bovys, Tolley, Krystal A., Ziyomo, Cathrine, Mapholi, Ntanganedzeni, Muigai, Anne, and Djikeng, Appolinaire

Abstract

Africa, a continent of 1.3 billion people, had 326 researchers per one million people in 2018 (Schneegans, 2021; UNESCO, 2022), despite the global average for the number of researchers per million people being 1368 (Schneegans, 2021; UNESCO, 2022). Nevertheless, a strong research community is a requirement to advance scientific knowledge and innovation and drive economic growth (Agnew, et al., 2020; Sianes, et al., 2022). This low number of researchers extends to scientific research across Africa and finds resonance with genomic projects such as the African BioGenome Project (Ebenezer, et al., 2022).The African BioGenome project (AfricaBP) plans to sequence 100,000 endemic African species in 10 years (Ebenezer, et al., 2022) with an estimated 203,000 gigabases of DNA sequence. AfricaBP aims to generate these genomes on-the-ground in Africa. However, for AfricaBP to achieve its goals of on-the-ground sequencing and data analysis, there is a need to empower African scientists and institutions to obtain the required skill sets, capacity and infrastructure to generate, analyse, and utilise these sequenced genomes in-country.The Open Institute is the genomics and bioinformatics knowledge exchange programme for the AfricaBP (Figures 1 & 2). It consists of 10 participating institutions including the University of South Africa in South Africa and National Institute of Agricultural Research in Morocco. It aims to: develop biodiversity genomics and bioinformatics curricula targeted at African scientists, promote and develop genomics and bioinformatics tools that will address critical needs relevant to the African terrain such as limited internet access, and advance grassroot knowledge exchange through outreach and public engagement such as quarterly training and workshops.

Published
2023

26. Improving livestock genetics to enhance animal welfare and production for African smallholder farmers

Author

Argyle, David, Djikeng, Appolinaire, Morrison, Liam, and Bronsvoort, Mark

Abstract

Animal production in low- and middle-income countries (LMICs), predominantly smallholder systems, faces considerable challenges. Low productivity, exposure to multiple pathogens, and climate-related stresses all cause major animal health and welfare issues. Unless addressed, these challenges will continue to negate initiatives aiming for sustainable animal production. To address this, the Royal (Dick) School of Veterinary Studies jointly established the Centre for Tropical Livestock Genetics and Health (CTLGH) with partners in Nairobi and Edinburgh (https://www.ctlgh.org/) to apply genetic improvement for improved animal productivity, health, and welfare in LMICs.

Published
2022

29. A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells

Author

Hu, Tuanjun, Taylor, Lorna, Sherman, Adrian, Keambou Tiambo, Christian, Whitelaw, Bruce, Hawken, Rachel, Djikeng, Appolinaire, and McGrew, Mike

Subjects
biobank, animal structures, avian, chicken, embryonic structures, germ cell, gametogenesis
Abstract

Chickens are an important resource for smallholder farmers who raise locally adapted, genetically distinct breeds for eggs and meat. The development of efficient reproductive technologies to conserve and regenerate chicken breeds safeguards existing biodiversity and secures poultry genetic resources for climate resilience, biosecurity, and future food production. The majority of the over 1600 breeds of chicken are raised in low and lower to middle income countries (LMICs) under resource limited, small scale production systems, which necessitates a low tech, cost effective means of conserving diversity is needed. Here, we validate a simple biobanking technique using cryopreserved embryonic chicken gonads. The gonads are quickly isolated, visually sexed, pooled by sex, and cryopreserved. Subsequently, the stored material is thawed and dissociated before injection into sterile host chicken embryos. By using pooled GFP and RFP-labelled donor gonadal cells and Sire Dam Surrogate (SDS) mating, we demonstrate that chicks deriving entirely from male and female donor germ cells are hatched. This technology will enable ongoing efforts to conserve chicken genetic diversity for both commercial and small holder farmers, and to preserve existing genetic resources at poultry research facilities.

Published
2022

32. A countrywide molecular survey leads to a seminal identification of the invasive cattle tick Rhipicephalus (Boophilus) microplus in Cameroon, a decade after it was reported in Cote d’Ivoire

Author

Silatsa, Barberine A., Kuiate, Jules-Roger, Njiokou⁠, Flobert, Simo, Gustave, Kameni, Jean-Marc F., Alabi, Tunrayo, Amzati, Gaston S., Bett, Bernard, Bishop, Richard, Githaka, Naftaly W., Opiyo, Stephen O., Djikeng, Appolinaire, and Pelle, Roger

Subjects
Genotyping, Polymorphism, Genetic, fungi, Cattle Diseases, Genetic Variation, Article, Tick Infestations, Cote d'Ivoire, Cross-Sectional Studies, genotyping, Rhipicephalus microplus, Haplotypes, RNA, Ribosomal, 16S, parasitic diseases, Epidemiological Monitoring, Rhipicephalus, Animals, Cattle, phylogenetic tree, Cameroon, Animal Distribution, Algorithms, Phylogeny, Phylogenetic tree
Abstract

The cattle tick Rhipicephalus microplus is the most important arthropod vector of livestock diseases globally. Since its introduction in West Africa a decade ago, it has been reported in Ivory Coast, Benin, Togo, Mali, Burkina Faso and Nigeria with potentially far-reaching adverse impacts on the livestock sector in the region. Cameroon is located on a major route for transboundary cattle trade between Central and West Africa and it is therefore at risk from R. microplus invasion. This study investigated the occurrence of R. microplus in Cameroon, the genetic polymorphism of the tick and population structure of isolates from different regions of the country to provide data that underpin the design of future vector control programs.A cross-sectional survey was conducted in which ticks were collected from cattle at 54 sites across the five Agroecological zones (AEZs) within Cameroon. Tick identity (sex and species) was assigned using taxonomic keys. Species identity was confirmed through amplification and sequencing of the mitochondrial COI and 16S rRNA genes. A total of 7091 ticks were collected out of which 1112 (15.6%) were morphologically identified as R. microplus. The presence of R. microplus was confirmed in 4 out of 5 agroecological zones. Only two haplotypes were identified by both COI and 16S rRNA genes, indicating a very low divergence in the genetic structure of the R. microplus population in Cameroon. 16S rRNA sequence analysis revealed a new haplotype specific to Cameroon. Phylogenetic trees revealed that all isolates of R. microplus from Cameroon were grouped into the previously described Africa/Americas clade. Application of a niche modelling algorithm to R. microplus distribution in Cameroon predicted that suitable habitat for the tick extended into southern Nigeria.This study demonstrated for the first time the presence of R. microplus in Cameroon. Genetic diversity tests indicate that the tick has not evolved significantly since the initial introduction to West Africa. We suggest further longitudinal studies to better define the spatial and temporal expansion of the range of the tick and the drivers of this spread.

Published
2019

33. Multiple Country and Breed Genomic Prediction of Tick Resistance in Beef Cattle

Author

Cardoso, Fernando Flores, primary, Matika, Oswald, additional, Djikeng, Appolinaire, additional, Mapholi, Ntanganedzeni, additional, Burrow, Heather M., additional, Yokoo, Marcos Jun Iti, additional, Campos, Gabriel Soares, additional, Gulias-Gomes, Claudia Cristina, additional, Riggio, Valentina, additional, Pong-Wong, Ricardo, additional, Engle, Bailey, additional, Porto-Neto, Laercio, additional, Maiwashe, Azwihangwisi, additional, and Hayes, Ben J., additional

Published
2021
Full Text
View/download PDF

34. Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub‐Saharan African goats

Author

Tarekegn, Getinet M., primary, Khayatzadeh, Negar, additional, Liu, Bin, additional, Osama, Sarah, additional, Haile, Aynalem, additional, Rischkowsky, Barbara, additional, Zhang, Wenguang, additional, Tesfaye, Kassahun, additional, Dessie, Tadelle, additional, Mwai, Okeyo A., additional, Djikeng, Appolinaire, additional, and Mwacharo, Joram M., additional

Published
2021
Full Text
View/download PDF

35. Whole-Genome Sequence Data Suggest Environmental Adaptation of Ethiopian Sheep Populations

Author

Wiener, Pamela, primary, Robert, Christelle, additional, Ahbara, Abulgasim, additional, Salavati, Mazdak, additional, Abebe, Ayele, additional, Kebede, Adebabay, additional, Wragg, David, additional, Friedrich, Juliane, additional, Vasoya, Deepali, additional, Hume, David A, additional, Djikeng, Appolinaire, additional, Watson, Mick, additional, Prendergast, James G D, additional, Hanotte, Olivier, additional, Mwacharo, Joram M, additional, and Clark, Emily L, additional

Published
2021
Full Text
View/download PDF

36. Comparative genomics of trypanosomatid parasitic protozoa

Author

Sayed, Najib M. El-, Myler, Peter J., Blandin, Gaelle, Berriman, Matthew, Crabtree, Jonathan, Aggarwal, Gautam, Caler, Elisabet, Renauld, Hubert, Worthey, Elizabeth A., Hertz-Fowler, Christiane, Ghedin, Elodie, Peacock, Christopher, Bartholomeu, Daniella C., Haas, Brian J., Tran, Anh-Nhi, Wortman, Jennifer R., Alsmark, U. Cecilia M., Angiuoli, Samuel, Anupama, Atashi, Badger, Jonathan, Bringaud, Frederic, Cadag, Eithon, Carlton, Jane M., Cerqueira, Gustavo C., Creasy, Todd, Delcher, Arthur L., Djikeng, Appolinaire, Embley, T. Martin, Hauser, Christopher, Ivens, Alasdair C., Kummerfeld, Sarah K., Pereira-Leal, Jose B., Nilsson, Daniel, Peterson, Jeremy, Salzberg, Steven L., Shallom, Joshua, Silva, Joana C., Sundaram, Jaideep, Westenberger, Scott, White, Owen, Melville, Sara E., Donelson, John E., Andersson, Bjorn, Stuart, Kenneth D., and Hall, Neil

Subjects
Leishmaniasis -- Genetic aspects, Trypanosoma cruzi -- Genetic aspects, Trypanosoma brucei -- Genetic aspects, Science and technology, Genetic aspects
Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that--along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions--have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont., The protozoan pamogens Leishmania major, Trypanosoma cruzi, and Trypanosoma brucei (family Trypanosomatidae, order Kinetoplastida) collectively cause disease and death in millions of humans and countless infections in other mammals, primarily [...]

Published
2005

40. Bioengineering horizon scan 2020

Author

Kemp, Luke, primary, Adam, Laura, additional, Boehm, Christian R, additional, Breitling, Rainer, additional, Casagrande, Rocco, additional, Dando, Malcolm, additional, Djikeng, Appolinaire, additional, Evans, Nicholas G, additional, Hammond, Richard, additional, Hills, Kelly, additional, Holt, Lauren A, additional, Kuiken, Todd, additional, Markotić, Alemka, additional, Millett, Piers, additional, Napier, Johnathan A, additional, Nelson, Cassidy, additional, ÓhÉigeartaigh, Seán S, additional, Osbourn, Anne, additional, Palmer, Megan J, additional, Patron, Nicola J, additional, Perello, Edward, additional, Piyawattanametha, Wibool, additional, Restrepo-Schild, Vanessa, additional, Rios-Rojas, Clarissa, additional, Rhodes, Catherine, additional, Roessing, Anna, additional, Scott, Deborah, additional, Shapira, Philip, additional, Simuntala, Christopher, additional, Smith, Robert DJ, additional, Sundaram, Lalitha S, additional, Takano, Eriko, additional, Uttmark, Gwyn, additional, Wintle, Bonnie C, additional, Zahra, Nadia B, additional, and Sutherland, William J, additional

Published
2020
Full Text
View/download PDF

41. Analysis of the Role of TpUB05 Antigen from Theileria parva in Immune Responses to Malaria in Humans Compared to Its Homologue in Plasmodium falciparum the UB05 Antigen

Author

Dinga, Jerome Nyhalah, primary, Perimbie, Stephanie Numenyi, additional, Gamua, Stanley Dobgima, additional, Chuma, Francis N. G., additional, Njimoh, Dieudonné Lemuh, additional, Djikeng, Appolinaire, additional, Pelle, Roger, additional, and Titanji, Vincent P. K., additional

Published
2020
Full Text
View/download PDF

43. Draft genome sequence of Solanum aethiopicum provides insights into disease resistance, drought tolerance, and the evolution of the genome

Author

Song, Bo, primary, Song, Yue, additional, Fu, Yuan, additional, Kizito, Elizabeth Balyejusa, additional, Kamenya, Sandra Ndagire, additional, Kabod, Pamela Nahamya, additional, Liu, Huan, additional, Muthemba, Samuel, additional, Kariba, Robert, additional, Njuguna, Joyce, additional, Maina, Solomon, additional, Stomeo, Francesca, additional, Djikeng, Appolinaire, additional, Hendre, Prasad S, additional, Chen, Xiaoli, additional, Chen, Wenbin, additional, Li, Xiuli, additional, Sun, Wenjing, additional, Wang, Sibo, additional, Cheng, Shifeng, additional, Muchugi, Alice, additional, Jamnadass, Ramni, additional, Shapiro, Howard-Yana, additional, Van Deynze, Allen, additional, Yang, Huanming, additional, Wang, Jian, additional, Xu, Xun, additional, Odeny, Damaris Achieng, additional, and Liu, Xin, additional

Published
2019
Full Text
View/download PDF

44. The genome of the blood fluke Schistosoma mansoni

Author

Berriman, Matthew, Haas, Brian J., LoVerde, Philip T., Wilson, Alan R., Dillon, Gary P., Cerqueira, Gustavo C., Mashiyama, Susan T., Al-Lazikani, Bissan, Andrade, Luiza F., Ashton, Peter D., Aslett, Martin A., Bartholomeu, Daniella C., Blandin, Gaelle, Caffrey, Conor R., Coghlan, Avril, Coulson, Richard, Day, Tim A., Delcher, Art, DeMarco, Ricardo, Djikeng, Appolinaire, Eyre, Tina, Gamble, John A., Ghedin, Elodie, Gu, Yong, Hertz-Fowler, Christiane, Hirai, Hirohisha, Hirai, Yuriko, Houston, Robin, Ivens, Alasdair, Johnston, David A., Lacerda, Daniela, Macedo, Camila D., McVeigh, Paul, Ning, Zemin, Oliveira, Guilherme, Overington, John P., Parkhill, Julian, Pertea, Mihaela, Pierce, Raymond J., Protasio, Anna V., Quail, Michael A., Rajandream, Marie-Adèle, Rogers, Jane, Sajid, Mohammed, Salzberg, Steven L., Stanke, Mario, Tivey, Adrian R., White, Owen, Williams, David L., Wortman, Jennifer, Wu, Wenjie, Zamanian, Mostafa, Zerlotini, Adhemar, Fraser-Liggett, Claire M., Barrell, Barclay G., and El-Sayed, Najib M.

Published
2009
Full Text
View/download PDF

47. MOESM9 of Genetic and antigenic variation of the bovine tick-borne pathogen Theileria parva in the Great Lakes region of Central Africa

Author

Amzati, Gaston, Djikeng, Appolinaire, Odongo, David, Nimpaye, Herman, Kgomotso Sibeko, Jean-Berckmans Muhigwa, Madder, Maxime, Kirschvink, Nathalie, and Marcotty, Tanguy

Abstract

Additional file 9: Table S7. Distribution of Tp1 gene alleles of T. parva from cattle and buffalo in the sub-Saharan region of Africa.

Published
2019
Full Text
View/download PDF

48. MOESM4 of A comprehensive survey of the prevalence and spatial distribution of ticks infesting cattle in different agro-ecological zones of Cameroon

Author

Silatsa, Barberine, Simo, Gustave, Naftaly Githaka, Mwaura, Stephen, Rolin Kamga, Farikou Oumarou, Keambou, Christian, Bishop, Richard, Djikeng, Appolinaire, Jules-Roger Kuiate, Flobert Njiokou, and Pelle, Roger

Abstract

Additional file 4: Figure S3. Rhipicephalus annulatus dorsal and ventral views.

Published
2019
Full Text
View/download PDF

49. Comparative genomic analysis and phylogenetic position of Theileria equi

Author

Kappmeyer Lowell S, Thiagarajan Mathangi, Herndon David R, Ramsay Joshua D, Caler Elisabet, Djikeng Appolinaire, Gillespie Joseph J, Lau Audrey OT, Roalson Eric H, Silva Joana C, Silva Marta G, Suarez Carlos E, Ueti Massaro W, Nene Vishvanath M, Mealey Robert H, Knowles Donald P, and Brayton Kelly A

Subjects
Apicomplexa, Parasite, Vaccine, Horse, Vector-borne disease, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Transmission of arthropod-borne apicomplexan parasites that cause disease and result in death or persistent infection represents a major challenge to global human and animal health. First described in 1901 as Piroplasma equi, this re-emergent apicomplexan parasite was renamed Babesia equi and subsequently Theileria equi, reflecting an uncertain taxonomy. Understanding mechanisms by which apicomplexan parasites evade immune or chemotherapeutic elimination is required for development of effective vaccines or chemotherapeutics. The continued risk of transmission of T. equi from clinically silent, persistently infected equids impedes the goal of returning the U. S. to non-endemic status. Therefore comparative genomic analysis of T. equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T. equi relative to sequenced apicomplexan parasites. Results The known immunodominant proteins, EMA1, 2 and 3 were discovered to belong to a ten member gene family with a mean amino acid identity, in pairwise comparisons, of 39%. Importantly, the amino acid diversity of EMAs is distributed throughout the length of the proteins. Eight of the EMA genes were simultaneously transcribed. As the agents that cause bovine theileriosis infect and transform host cell PBMCs, we confirmed that T. equi infects equine PBMCs, however, there is no evidence of host cell transformation. Indeed, a number of genes identified as potential manipulators of the host cell phenotype are absent from the T. equi genome. Comparative genomic analysis of T. equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp. Conclusions The EMA family does not fit the paradigm for classical antigenic variation, and we propose a novel model describing the role of the EMA family in persistence. T. equi has lost the putative genes for host cell transformation, or the genes were acquired by T. parva and T. annulata after divergence from T. equi. Our analysis identified 50 genes that will be useful for definitive phylogenetic classification of T. equi and closely related organisms.

Published
2012
Full Text
View/download PDF

50. Viral metagenomics demonstrates that domestic pigs are a potential reservoir for Ndumu virus

Author

Masembe Charles, Michuki George, Onyango Maria, Rumberia Cecilia, Norling Martin, Bishop Richard P, Djikeng Appolinaire, Kemp Stephen J, Orth Alan, Skilton Robert A, Ståhl Karl, and Fischer Anne

Subjects
Metagenomics, Ndumu virus, Pigs, Reservoir, Zoonoses, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The rising demand for pork has resulted in a massive expansion of pig production in Uganda. This has resulted in increased contact between humans and pigs. Pigs can act as reservoirs for emerging infectious diseases. Therefore identification of potential zoonotic pathogens is important for public health surveillance. In this study, during a routine general surveillance for African swine fever, domestic pigs from Uganda were screened for the presence of RNA and DNA viruses using a high-throughput pyrosequencing method. Findings Serum samples from 16 domestic pigs were collected from five regions in Uganda and pooled accordingly. Genomic DNA and RNA were extracted and sequenced on the 454 GS-FLX platform. Among the sequences assigned to a taxon, 53% mapped to the domestic pig (Sus scrofa). African swine fever virus, Torque teno viruses (TTVs), and porcine endogenous retroviruses were identified. Interestingly, two pools (B and C) of RNA origin had sequences that showed 98% sequence identity to Ndumu virus (NDUV). None of the reads had identity to the class Insecta indicating that these sequences were unlikely to result from contamination with mosquito nucleic acids. Conclusions This is the first report of the domestic pig as a vertebrate host for Ndumu virus. NDUV had been previously isolated only from culicine mosquitoes. NDUV therefore represents a potential zoonotic pathogen, particularly given the increasing risk of human-livestock-mosquito contact.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results