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Indirect Drive Inertial Confinement Fusion Experiments on the National Ignition Facility (NIF) have achieved a burning plasma state with neutron yields exceeding 170 kJ, roughly 3 times the prior record and a necessary stage for igniting plasmas. The results are achieved despite multiple sources of degradations that lead to high variability in performance. Results shown here, for the first time, include an empirical correction factor for mode-2 asymmetry in the burning plasma regime in addition to previously determined corrections for radiative mix and mode-1. Analysis shows that including these three corrections alone accounts for the measured fusion performance variability in the two highest performing experimental campaigns on the NIF to within error. Here we quantify the performance sensitivity to mode-2 symmetry in the burning plasma regime and apply the results, in the form of an empirical correction to a 1D performance model. Furthermore, we find the sensitivity to mode-2 determined through a series of integrated 2D radiation hydrodynamic simulations to be consistent with the experimentally determined sensitivity only when including alpha-heating.

The budget of reactive nitrogen species, which play a central role in atmospheric chemistry (e.g. in photochemical O3 production), is poorly understood in forested regions. In this study, through observations of NO, NO2, NOy, and O3 in the Rambouillet Forest near Paris, France, we have examined nighttime processes controlling NOx in an anthropogenically impacted forest environment. The O3 mixing ratios displayed a strong diel profile at the site that was driven by a variable but generally rapid deposition to soil and foliar surfaces. The O3 diel profile was strongly influenced by relative humidity and temperature inversion. Only when the O3 mixing ratio was sufficiently low (and thus the NO lifetime sufficiently long) were sustained NO peaks observed above the instrumental detection limit, enabling the derivation of average NO emission rates of ∼1.4 ppbv h−1 from the soil. Observations of the lack of increase in NO2 at night, despite a significant production rate from the reaction of NO with O3, enabled an effective lifetime of NO2 of ∼0.5–3 h to be derived. As the loss of NO2 was not compensated for by the formation of gas- or particle-phase reactive nitrogen species, it was presumably either driven by deposition to soil and foliar surfaces or any products formed were themselves short-lived with respect to deposition. By comparison, the daytime lifetime of NO2 with respect to loss by reaction with OH is about 1 d. Our results indicate that the nighttime deposition of NO2 is a major sink of boundary layer NOx in this temperate forest environment.

We present direct measurements of biogenic volatile organic compound (BVOC)-induced nitrate radical (NO3) reactivity (kVOC) through the diel cycle in the suburban, temperate forest of Rambouillet near Paris (France). The data were obtained in a 6-week summer period in 2022 as part of the Atmospheric ChemistRy Of the Suburban foreSt (ACROSS) campaign. kVOC was measured in a small (700 m2) clearing mainly at a height of 5.5 m above ground level but also at 40 m (for 5 d and nights). At nighttime, mean values (and 25th–75th percentile ranges) of knightVOC(5.5m) = (0.24-0.06+0.32) s−1 and knightVOC(40m) = (0.016-0.007+0.018) s−1 indicate a significant vertical gradient and low NO3 reactivity above the canopy, whereas knightVOC(5.5 m) showed peak values of up to 2 s−1 close to the ground. The strong vertical gradient in NO3 reactivity could be confirmed by measurements between 0 and 24 m on one particular night characterized by a strong temperature inversion and is a result of the decoupling of air masses aloft from the ground- and canopy-level sources of BVOCs (and nitric oxide, NO). No strong vertical gradient was observed in the mean daytime NO3 reactivity, with kdayVOC(5.5m) = (0.12 ± 0.04) s−1 for the entire campaign and kdayVOC(40m) = (0.07 ± 0.02) s−1 during the 5 d period. Within the clearing, the fractional contribution of VOCs to the total NO3 loss rate coefficient (ktot, determined by photolysis, reaction with NO and VOCs) was 80 %–90 % during the night and ∼ 50 % during the day. In terms of chemical losses of α-pinene below canopy height in the clearing, we find that at nighttime hydroxyl radicals (OH) and ozone (O3) dominate, with NO3 contributing “only” 17 %, which decreases further to 8.5 % during the day. Based on measured OH, measured O3, and calculated NO3 concentrations, the chemical lifetime of BVOCs at noon is about 1 h and is likely to be longer than timescales of transport out of the canopy (typically of the order of minutes), thus significantly reducing the importance of daytime in-canopy processing. Clearly, in forested regions where sufficient nitric oxide and nitrogen dioxide (NOx) is available, the role of NO3 and OH as initiators of BVOC oxidation is not strictly limited to nighttime and daytime, respectively, as often implied in e.g. atmospheric chemistry textbooks.

Lead (Pb) is a neurotoxicant with early life exposure linked to long-term health effects. Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWIL proteins to induce DNA methylation. It remains unknown whether Pb exposure influences piRNA expression. This study evaluated how perinatal Pb exposure (32 ppm in drinking water) impacts piRNA expression in adult mice and assessed piRNA dysregulation as a potential mechanism for Pb-induced toxicity. Pb exposure effects on piRNA expression and associated gene repression in the germline (testis/ovary) and soma (liver and brain) were evaluated. Small RNA sequencing was used to determine differentially expressed piRNAs, RT-qPCR to examine piRNA target expression, and whole genome bisulfite sequencing to evaluate target DNA methylation status. Three piRNAs (mmpiR-1500602, mmpiR-0201406, and mmpiR-0200026) were significant after multiple testing correction (all downregulated in the male Pb-exposed brain in comparison to control; FDR

Despite being a well-established economic activity in numerous countries in the world, domestic tourism has received relatively little academic exploration, particularly in Namibia. While this study acknowledges the significance of work already done in this field, there remains a general lack of understanding of the factors motivating domestic tourists’ decisions to travel in the study area. As a result, this study aims to understand the key push and pull factors for domestic tourists, using the Erongo region of Namibia as a case study. The study adopts a quantitative research approach through a survey of 400 domestic tourists in the study area. Relaxation and escapism, seeking participatory experiences, and seeking enriching experiences emerged as the three main push factors, while destination attributes, events and activities, safety and familiarity, and variety of experiences were identified as dominant pull factors. The study recommends that tourism planners and marketers tailor tourism offerings to the asserted domestic tourists’ motivations to induce more domestic tourism demand and consumption among domestic tourists.

Background Greenness—or vegetative presence—has been identified as a factor in chronic disease. The present study examines the longitudinal relationship between objective measures of greenness at the residential block level and incidence of 6 cardiovascular disease conditions. Methods and Results Analyses examined the impact of consistently high versus consistently low “precision” greenness at the Census block level on the 5‐year incidence of cardiovascular disease conditions, including acute myocardial infarction, atrial fibrillation, heart failure, ischemic heart disease, stroke/transient ischemic attack, and hypertension, among 229 034 US Medicare beneficiaries in Miami‐Dade County, Florida, USA. Zero‐inflated Poisson regression was used to model the odds of developing any new cardiovascular disease and number of new cardiovascular disease conditions based on greenness tertiles computed across 2011 and 2016 Normalized Difference Vegetation Index values, adjusting for individual age, sex, race, ethnicity, baseline cardiovascular disease conditions, neighborhood income, and walkability in 2011 and 2016. When compared with individuals consistently in the low greenness tertile in 2011 and 2016, those consistently in the high greenness tertile in 2011 and 2016 had a 9% lower odds of having any new cardiovascular conditions (odds ratio [OR], 0.91 [95% CI, 0.84–0.99]; P=0.021). Conclusions Over a 5‐year period, consistently high greenness, when compared with consistently low greenness, was associated with lower odds of any new cardiovascular disease conditions. Identifying the role of greenness exposure in such a small geographic area, the Census block on which the older adult resides, allows for more precise, strategic decisions on where additional trees can be added—by selecting at‐risk blocks rather than entire neighborhoods for tree‐planting interventions.

Effective legislative framework is the cornerstone of managing hazards and disasters because they have become policy problems of global and local concern. This research study aims at understanding the implementation, strengths and gaps of policies related to Eco-DRR in SADC member states. In particular, attempts to critically analyse the making of DRM policies, as well as the variables underpinning these policies, given the high level of disaster losses. A literature survey was conducted to contextualise and conceptualise statutory and policy-based Eco-DRR. Academic literature on Eco-DRR and related policies, journal articles and related policies, official documents in SADC states including policies, acts, legislations, strategies, frameworks and plans were consulted. The analysis revealed that the Eco-DRR approaches have not yet been mainstreamed as part of standards of DRM in most of SADC member states, opting largely on ad hoc practice. Short-term plans and/or strategies don’t help to articulate funding and programme priorities. In addition, irregular updating of policies in some member states and a lack of following up mechanisms were noted. Contribution: To change this reality, it is necessary to include Eco-DRR in strategies and/or plans and to standardise ecosystem-based measures for reducing disaster risks. Additionally, there is an urgent need for empowerment of the existing institutions and creation of networks that are driven by SADC institutions. Overall, it is evident that there is a regional interest and demand to apply and standardise ecosystem-based approaches and natural or green infrastructure solutions toward Eco-DRR.

ObjectiveVasoplegic syndrome remains a common complication of cardiac surgery. It has serious implications for the healthcare system and individual patients, as it leads to rising healthcare costs and higher mortality. A better understanding of factors triggering vasoplegic syndrome is essential for the development of effective prevention strategies. We aimed to identify clinical characteristics and intraoperative parameters associated with the development of vasoplegic syndrome in coronary artery bypass graft surgery and the influence of vasoplegia on outcome.MethodsWe retrospectively analyzed the data of all patients who underwent isolated coronary artery bypass graft surgery or coronary artery bypass graft surgery combined with atrial appendage occlusion, using the heart-lung machine at our institution from 04/2019 to 12/2020. Vasoplegic syndrome was defined as MAP ≤60 mmHg and norepinephrine equivalence dosage of ≥0.2 μg/kg/min with a central venous saturation ≥60% within 2 days from surgery.ResultsOf 647 patients included in this study, 72 (11.1%) developed vasoplegic syndrome. Patients experiencing vasoplegia had longer stay in ICU, more frequently underwent tracheostomy and suffered more often from pneumonia. The duration of extracorporeal circulation, intraoperative application of platelet concentrates and usage of cold crystalloid cardioplegia (Bretschneider) independently predicted development of vasoplegic syndrome.ConclusionsEven in relatively low-risk cardiac surgery, vasoplegic syndrome is a common complication and was associated with serious adverse effects. The use of warm blood cardioplegia (Calafiore) seems to be safer than cold crystalloid cardioplegia (Bretschneider) and might be preferable in patients that are vulnerable to the consequences of vasoplegic syndrome.

Background: There are various experimental measurement techniques used to measure residual stress and this work describes one such method, the slotting method, and its application to measure near surface residual stresses. Objective: This work examines its application to macro-scale specimens. Methods: A series of numerical experiments were performed to understand the size required to assume that the specimen is infinitely large, namely the thickness, width, and height. To assess measurement repeatability, 12 slotting measurements were performed in a shot peened aluminum plate. Results: The numerical experiments determined the specimen should have a thickness greater than or equal to 21.6 mm (0.85 in), a total specimen width (normal to the slot length) greater than or equal to 44.5 mm (1.75 in), and total height (parallel to the slot) greater than or equal to 38.1 mm (1.5 in) for the specimen to be assumed to be infinite. Slotting measurement repeatability was found to have a maximum repeatability standard deviation of 30 MPa at the surface that decays rapidly to 5 MPa at a depth of 0.3 mm from the surface. Comparison x-ray diffraction measurements were performed. Conclusions: Infinite plate dimensions and slot length were determined as well as measurement repeatability. Slotting was shown to have significantly better repeatability than X-ray diffraction with layer removal for this application.

In this work we present the results from two experiments dedicated to search for quadrupolecollective isovector valence-shell excitation, the states with so-called mixed proton-neutron symmetry (MSS), in nuclei around the doubly magic nucleus 208Pb. 212Po was studied in an α-transfer reaction. 204Hg was studied in an inverse kinematics Coulomb excitation reaction on a carbon target. Both experiments provide indications for existence of one-phonon MSSs. Those are the first experimentally identified MSSs in the mass A ≈ 208 region.

Two odd-odd nuclei from the A ~ 100 and A ~ 130 regions, namely 102Rh and 134Pr have been studied in search for chiral doublet bands via 94Zr(11B,3n)102Rh and 119Sn(19F,4n)134Pr reactions, respectively. Two nearly degenerate bands built on the πg9/2 ⊗ vh11/2 configuration have been identified in 102Rh and on the πg11/2 ⊗ vh11/2 configuration for 134Pr. Lifetimes of excited nuclear states were measured using Dopplershift attenuation method and recoil distance Doppler-shift method. The deexciting gamma rays were registered by the Indian National Gamma Array for 102Rh and using the EUROBALL IV detector array with an inner Bismuth Germanate (BGO) ball for 134Pr, respectively. Polarization and angular correlation measurements have been performed to establish the spin and parity assignments for these bands. The derived reduced transition probabilities are compared to the predicitons of the two quasiparticles + triaxial rotor and interacting boson fermion-fermion models.

IntroductionHand opening is reduced by abnormal wrist and finger flexor activity in many individuals with stroke. This flexor activity also limits hand opening produced by functional electrical stimulation (FES) of finger and wrist extensor muscles. Recent advances in electrical nerve block technologies have the potential to mitigate this abnormal flexor behavior, but the actual impact of nerve block on hand opening in stroke has not yet been investigated.MethodsIn this study, we applied the local anesthetic ropivacaine to the median and ulnar nerve to induce a complete motor block in 9 individuals with stroke and observed the impact of this block on hand opening as measured by hand pentagonal area. Volitional hand opening and FES-driven hand opening were measured, both while the arm was fully supported on a haptic table (Unloaded) and while lifting against gravity (Loaded). Linear mixed effect regression (LMER) modeling was used to determine the effect of Block.ResultsThe ropivacaine block allowed increased hand opening, both volitional and FES-driven, and for both unloaded and loaded conditions. Notably, only the FES-driven and Loaded condition’s improvement in hand opening with the block was statistically significant. Hand opening in the FES and Loaded condition improved following nerve block by nearly 20%.ConclusionOur results suggest that many individuals with stroke would see improved hand-opening with wrist and finger flexor activity curtailed by nerve block, especially when FES is used to drive the typically paretic finger and wrist extensor muscles. Such a nerve block (potentially produced by aforementioned emerging electrical nerve block technologies) could thus significantly address prior observed shortcomings of FES interventions for individuals with stroke.

Background: Residual stress spatial mapping has been developed using various measurement methods, one such method comprising a multiplicity of one-dimensional slitting method measurements combined to form a two-dimensional (2D) map. However, an open question is how to best distribute the individual slitting measurements for 2D mapping. Objective: This paper investigates the efficacy of different strategies for laying out the individual slitting measurements when mapping in-plane residual stress in thin stainless steel slices removed from a larger dissimilar metal weld. Methods: Three different measurement layouts are assessed: independent measurements on nominally identical specimens (i.e., one slitting measurement per specimen, with many specimens), repeatedly bisecting a single slice, and making nominally sequential measurements from one side of the specimen towards the other side of the specimen. Additional comparison measurements are made using neutron diffraction. Results: The work shows little difference between the independent and bisecting slitting measurement layouts, and some differences with the sequential measurements. There is good general agreement between neutron diffraction measurement data and the data from the independent and bisecting layouts. Conclusions: This work suggests that when using slitting to create a 2D map of in-plane residual stress, a cutting layout that repeatedly bisects the specimen works well, requires a small number of specimens, and avoids potential errors from geometric asymmetry or measurement sequence.

To investigate the interplay between collective and single particle degrees of freedom in odd nuclei, Recoil distance Doppler-shift and Doppler-shift attenuation lifetime measurements were carried out for levels in 155Dy in coincidence detection of gamma-rays. 26 lifetimes were determined using the Differential decay curve method. Particle plus triaxial rotor model (PTRM) calculations were performed to compare the experimental level scheme and transition strengths with theoretical ones in order to get information on the quadrupole deformation (є,γ) of the bands. As a result, different quadrupole deformations for the one-quasineutron bands at low and medium spins are deduced.

Study designExpert consensus study.ObjectiveThis expert panel was created to establish best practice guidelines to identify and treat patients with poor bone health prior to elective spinal reconstruction.Summary of background dataCurrently, no guidelines exist for the management of osteoporosis and osteopenia in patients undergoing spinal reconstructive surgery. Untreated osteoporosis in spine reconstruction surgery is associated with higher complications and worse outcomes.MethodsA multidisciplinary panel with 18 experts was assembled including orthopedic and neurological surgeons, endocrinologists, and rheumatologists. Surveys and discussions regarding the current literature were held according to Delphi method until a final set of guidelines was created with over 70% consensus.ResultsPanelists agreed that bone health should be considered in every patient prior to elective spinal reconstruction. All patients above 65 and those under 65 with particular risk factors (chronic glucocorticoid use, high fracture risk or previous fracture, limited mobility, and eight other key factors) should have a formal bone health evaluation prior to undergoing surgery. DXA scans of the hip are preferable due to their wide availability. Opportunistic CT Hounsfield Units of the vertebrae can be useful in identifying poor bone health. In the absence of contraindications, anabolic agents are considered first line therapy due to their bone building properties as compared with antiresorptive medications. Medications should be administered preoperatively for at least 2 months and postoperatively for minimum 8 months.ConclusionBased on the consensus of a multidisciplinary panel of experts, we propose best practice guidelines for assessment and treatment of poor bone health prior to elective spinal reconstructive surgery. Patients above age 65 and those with particular risk factors under 65 should undergo formal bone health evaluation. We also established guidelines on perioperative optimization, utility of various diagnostic modalities, and the optimal medical management of bone health in this population.Level of Evidence: 5.

Abstract Adverse childhood experiences (ACE) have been linked to less prosocial behavior during social exclusion in vulnerable groups. However, little is known about the impact of the timing of ACE and the roles of protective factors. Therefore, this study investigated the association of the behavioral response to experimental partial social exclusion with adverse and adaptive experiences across age groups and resilience in clinical groups with persistent depressive disorder and borderline personality disorder, i.e., groups with high ACE, and in healthy controls (HC) (N = 140). Adverse and adaptive experiences during childhood, youth, and adulthood were assessed with the Traumatic Antecedents Questionnaire, and resilience was measured with the Connor Davidson Resilience Scale. A modified version of the Cyberball paradigm was used to assess the direct behavioral response to partial social exclusion. In patients, adverse events during youth (B = − 0.12, p = 0.016) and adulthood (B = − 0.14, p = 0.013) were negatively associated with prosocial behavior, whereas in the HC sample, adaptive experiences during youth were positively associated with prosocial behavior (B = 0.25, p = 0.041). Resilience did not mediate these effects. The findings indicate that critical events during youth may be particularly relevant for interpersonal dysfunction in adulthood.

Orientation: Employee job satisfaction is a widely studied concept with limited consensus on which factors of job satisfaction are most significant for tourism and hospitality employees. Specific factors of employee job satisfaction are critical to assist managers, practitioners, and academics, to enhance the levels of employee job satisfaction within national parks. Research purpose: To determine and rank the factors of job satisfaction that are most significant towards an overall job satisfaction of tourism and hospitality employees within national parks. Motivation for the study: Significant factors of job satisfaction will enable managers, practitioners, and academics to use specific factors of job satisfaction when addressing the levels of employee job satisfaction. Research approach/design and method: This article adopted a quantitative explanatory research approach using a structured e-questionnaire to collect data. The study had 211 participants. Descriptive statistics and correlation analysis were used to interpret data. Main findings: Key findings reveal that tourism and hospitality respondents within national parks have diverse demographical characteristics, and present work is among the most significant factor of job satisfaction while salary is least significant for these respondents. Practical/managerial implications: Managers and practitioners need to be specific when addressing factors of employee satisfaction. Managers need to pay more attention on employees’ present work than other factors. Contribution/value-add: This study makes a significant contribution towards the tourism employment literature because the tourism employment is associated with negative work characteristics. Managers are further provided with specific factors to measure job satisfaction.

When Jesus meets the Samaritan Woman at Jacob’s well in John 4, it is a meeting between two colonial subjects in the Roman Empire. In this encounter we find the Samaritan Woman as a triply marginalised body, a woman subject to multiple, intersecting forms of oppression within her patriarchal context. Identified as a Samaritan Woman, Jewish rabbis regarded her as unclean, impure, and being menstruous from birth. It can also be deduced that she is an outcast in her own society because she comes to draw from the well at noon, the hottest part of the day when people did not usually fetch water. This Samaritan Woman is nameless, landless and powerless in an imperial, colonial and patriarchal context. The poem of Diana Ferrus, I’ve come to take you home, in memory of Sarah Baartman, highlights how Baartman was dehumanised and treated as a sexual object by European colonisers. Through a postcolonial reading of John 4, I consider the intersections between the Samaritan Woman and the early life of Sara Baartman in their respective colonial contexts and invite the reader, as the poem invites Baartman, to come home to Africa and resist Western European imperial and colonial patterns and tendencies. Contribution: This article has interdisciplinary implications. This is an interdisciplinary study in the sense that it offers a biblical interpretation of John 4 that is informed by the life of Sara Baartman that has been uncovered through anthropology, history and sociology. It is also integrating the field of postcolonial biblical hermeneutics with the theory of intersectionality.

# Introduction Effective rehabilitation strategies for upper extremity injuries in softball pitchers are scarce in current literature, especially among youth athletes. Additionally, there continues to be ambiguity regarding the interpretation and clinical practicality when treating an overhead athlete with scapular dyskinesis. The purpose of this case report is to highlight the examination and treatment of a youth softball pitcher referred to physical therapy with the diagnosis of scapular dyskinesis. # Case Description This case report presents data and outcomes for a 14-year-old female who experienced chronic right shoulder discomfort related to performing the windmill softball pitch (WSP). The subject was clinically diagnosed with scapular dyskinesis by her referring physician and demonstrated abnormal scapular movement when elevating and lowering her upper extremity. Internal and external rotator isokinetic strength testing and the Athletic Shoulder Test (ASH) were used as primary objective measures. Both were performed six days after the initial evaluation and again six weeks later. Initial testing demonstrated decreased peak torque and total work. Initial treatment involved periscapular and shoulder strengthening with progression to overhead loading. Later rehabilitation strategies focused on neuromuscular control, functional training, and sport-specific activities. # Outcomes The subject initially demonstrated improved peak torque and total work of the shoulder with isokinetic strength testing but continued to have symptoms with pitching, even though the Scapular Dyskinesis Test had become negative. After changing the focus to neuromuscular and functional training the subject had fewer symptoms and became comfortable with self-management. # Discussion This case matches previous research that endorses scapular dyskinesis being a normal finding in overhead athletes with and without shoulder pain. Neuromuscular control and functional training after a period of scapular strengthening were beneficial in improving symptoms in this athlete. # Level of Evidence 5

In this contribution we report on the measurements performed so far at CologneAMS and on the quality which has been obtained for the isotopes 10Be, 14C and 26Al. We also describe the procedure developed to measure plutonium-isotopes at CologneAMS and first results for 239,240,242Pu are presented. In addition we report on modifications made on our new TOF device with beam profile capabilities.