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Purpose: By reviewing the available literature this paper made a solid foundation to the current scenario ofold age homes in geriatric care as a social necessity and the satisfaction of the inmates is a factor which measures the administrative efficiency of the old age homes. Administrative inefficiency and inadequacy of governance may contribute to poor treatment and poor treatment of members in old age homes. Medical care provided to the inmates in the old age homes is a major factor which contributes to the satisfaction level of the inmates along with several other factors. This study was taken place to examine the level of satisfaction of the inmates on the infrastructural factors such as atmosphere, facilities, environment, and behavior of staff toward the elderly inmates. Objective: The study tries to examine the administrative efficiency of old age homes for the elderly and the inmate’s level of satisfaction. Design/Methodology/Approach: The codes are taken from the literature and used in the review of literature. This research was explanatory research that was conducted through an exploratory approach. On the internet's platform, desktop research was carried out. Almost 100 research articles were reviewed in depth and studied to identify the research gap. Findings/Result: The review of the articles indicates elderly are quite satisfied with the efficiency of old age homes and they are happy to be there in the old age homes other than being isolated at home and also, they are comfortable with their embers in the caretaking homes. In this study it can be found that the level of satisfaction of old age home inmates is different from each other as there are different types of paid and non-paid old age homes. Originality/Value: This review presents key findings from studies that show the level of satisfaction of the inmates in the old age home. This article was unique in its way of being a review article and compiling a satisfactory report of elderly inmates of old age home in the past 15 years. In all these studies the researcher can find that the efficiency and satisfaction of the old age home are different from each other. Paper Type: It was a review-based study which is also known as an integrative review where many articles from the past 15 years were selected from different search engines such as Google scholar, Research gate, and others.

Functional timing analysis (FTA) is a renowned method of finding the true critical delay for the design under interest. By constructing conjunctive normal form (CNF) clauses based on temporal and function constraints, false paths can be identified through the satisfiability (SAT) solving. As a result, the critical delay estimated by FTA is more accurate than that by conventional static timing analysis (STA). However, FTA suffers from the extremely long formulation and computation time, as the number of the clauses in CNF grows exponentially with the increasing size of the design. Due to the reconvergent effect, thousands of clauses can be redundantly formulated for one pin. Even worse, most of them are found useless but seriously lengthen the computation time. Therefore, to avoid ineffective computation in FTA, three novel techniques are proposed: 1) encoding duplication removal (EDR) for removing duplicated functional literals; 2) redundant state propagation (RSP) for propagating temporal states to identify redundant clauses; and 3) temporal footprint identification (TFI) for combining clauses that represent constraints with the same behavior. The experiments show that under a given timing constraint, 94% clauses and 95% literals can be pruned averagely (99% clauses and 99% literals under the best case), resulting in $15.3 \times $ speedup ( $72.99 \times $ under the best case) for formulation and SAT solving. As a result, the proposed techniques (EDR, RSP, and TFI) are proven effective to reduce useless computation and improve the overall performance of FTA.

Background: Social media has become an established platform for individuals to discuss and debate various subjects, including vaccination. With growing conversations on the web and less than desired maternal vaccination uptake rates, these conversations could provide useful insights to inform future interventions. However, owing to the volume of web-based posts, manual annotation and analysis are difficult and time consuming. Automated processes for this type of analysis, such as natural language processing, have faced challenges in extracting complex stances such as attitudes toward vaccination from large amounts of text. Objective: The aim of this study is to build upon recent advances in transposer-based machine learning methods and test whether transformer-based machine learning could be used as a tool to assess the stance expressed in social media posts toward vaccination during pregnancy. Methods: A total of 16,604 tweets posted between November 1, 2018, and April 30, 2019, were selected using keyword searches related to maternal vaccination. After excluding irrelevant tweets, the remaining tweets were coded by 3 individual researchers into the categories Promotional, Discouraging, Ambiguous, and Neutral or No Stance. After creating a final data set of 2722 unique tweets, multiple machine learning techniques were trained on a part of this data set and then tested and compared with the human annotators. Results: We found the accuracy of the machine learning techniques to be 81.8% (F score=0.78) compared with the agreed score among the 3 annotators. For comparison, the accuracies of the individual annotators compared with the final score were 83.3%, 77.9%, and 77.5%. Conclusions: This study demonstrates that we are able to achieve close to the same accuracy in categorizing tweets using our machine learning models as could be expected from a single human coder. The potential to use this automated process, which is reliable and accurate, could free valuable time and resources for conducting this analysis, in addition to informing potentially effective and necessary interventions. (JMIR Med Inform 2021;9(10):e29584) doi: 10.2196/29584

Objective: To understand the predominant topics of discussion, stance and associated language used on social media platforms relating to maternal vaccines in 15 countries over a six-month period. Background: In 2019, the World Health Organisation prioritised vaccine hesitancy as a top ten global health threat and recognized the role of viral misinformation on social media as propagating vaccine hesitancy. Maternal vaccination offers the potential to improve maternal and child health, and to reduce the risk of severe morbidity and mortality in pregnancy. Understanding the topics of discussion, stance and language used around maternal vaccines on social media can inform public health bodies on how to combat vaccine misinformation and vaccine hesitancy. Methods: Social media data was extracted (Twitter, forums, blogs and comments) for six months from 15 countries (Australia, Brazil, Canada, France, Germany, India, Italy, Korea, Mexico, Panama, South Africa, Spain, United Kingdom and United States). We used stance, discourse and topic analysis to provide insight into the most frequent and weighted keywords, hashtags and themes of conversation within and across countries. Results: We exported a total of 19,192 social media posts in 16 languages obtained between 1st November 2018 and 30th April 2019. After screening all posts, 16,000 were included in analyses, while excluding retweets, 2,722 were annotated for sentiment. Main topics of discussion were the safety of the maternal influenza and pertussis vaccines. Discouraging posts were most common in Italy (44.9%), and the USA (30.8%). Conclusion: The content and stance of maternal vaccination posts from November 2018 to April 2019 differed across countries, however specific topics of discussion were not limited to geographical location. These discussions included the promotion of vaccination, involvement of pregnant women in vaccine research, and the trust and transparency of institutions. Future research should examine the relationship between stance (promotional, neutral, ambiguous, discouraging) online and maternal vaccination uptake in the respective regions. Crown Copyright (C) 2020 Published by Elsevier Ltd. All rights reserved.

Recent advances in DNA-sequencing technology have made it possible to obtain large datasets of small RNA sequences. Here we demonstrate that not all non-perfectly matched small RNA sequences are simple technological sequencing errors, but many hold valuable biological information. Analysis of three small RNA datasets originating from Oryza sativa and Arabidopsis thaliana small RNA-sequencing projects demonstrates that many single nucleotide substitution errors overlap when aligning homologous non-identical small RNA sequences. Investigating the sites and identities of substitution errors reveal that many potentially originate as a result of post-transcriptional modifications or RNA editing. Modifications include N1-methyl modified purine nucleotides in tRNA, potential deamination or base substitutions in micro RNAs, 3′ micro RNA uridine extensions and 5′ micro RNA deletions. Additionally, further analysis of large sequencing datasets reveal that the combined effects of 5′ deletions and 3′ uridine extensions can alter the specificity by which micro RNAs associate with different Argonaute proteins. Hence, we demonstrate that not all sequencing errors in small RNA datasets are technical artifacts, but that these actually often reveal valuable biological insights to the sites of post-transcriptional RNA modifications.

In recent years, much research has focused on developing tests to detect malingering. A drawback of existing tests is their poor ability to detect malingerers possessing more “sophisticated” knowledge of neuropsychological deficits. The current study presents preliminary validation data on a new measure, the Word Completion Memory Test (WCMT), which is the first malingering test to utilize a sophisticated coaching methodology in its development. The WCMT was administered to control participants, memory-impaired patients, and coached simulators. The coached simulators were provided with specific information about and examples of memory deficits commonly experienced following closed head injury (CHI; e.g., anterograde vs. retrograde amnesia). They also read a detailed scenario describing the lifestyle and motivations likely experienced by CHI litigants, and then practiced their roles by taking a quiz about their deficits. Results showed that 93% of coached simulators and 100% of control and memory-impaired participants were correctly classified by the WCMT.

This study explores the revelation effect, a recognition memory phenomenon that occurs when test items (or related items) are specially processed before recognition judgment. These revealed items, whether targets or lures, receive a positive response bias. Although the effect occurs across various conditions, it has not been shown to occur when participants make judgments unrelated to episodic memory. We investigated whether the effect would occur when a recognition decision was nominally one of episodic memory, but when a complete episodic event had not occurred. Specifically, participants listened to noise that allegedly masked a list of words (in fact, no words existed). A revelation effect occurred with this pseudo-subliminal procedure, suggesting that the revelation effect need not rely on stimuli recalled through episodic memory but only a specific event to recall. The effect did not occur when participants simply guessed whether words were on an unheard list or made semantic judgments.

The irrelevant speech effect is the impairment of task performance by the presentation of to-be-ignored speech stimuli. Typically, the irrelevant speech comprises a variety of sounds, but previous research (e.g., Jones, Madden, & Miles, 1992) has suggested that the deleterious effect of background speech is virtually eliminated if the speech comprises repetitions of a sound (e.g., “be, be, be”) or a single continuous sound (e.g., “beeeeeee”). Four experiments are reported that challenge this finding. Experiments 1, 2, and 4 show a substantial impairment in serial recall performance in the presence of a repeated sound, and Experiments 3 and 4 show a similar impairment of serial recall in the presence of a continuous sound. The relevance of these findings to several explanations of the irrelevant speech effect is discussed.

Melanoma mortality is directly linked to its profoundly metastatic nature and inherent resistance to conventional chemotherapy. For this reason, increased understanding of the molecular mechanisms driving melanoma progression is of utmost importance. The p21-activated serine/threonine kinases (PAKs) are frequently mutated or overexpressed in cancer and have recently been implicated in tumor metastasis, proliferation, and apoptotic resistance. This observation has inspired drug discovery efforts to limit PAK activity; yet, mechanistic understanding of how PAKs (especially Type II PAKs) contribute to tumor initiation and progression is still evolving. PAK7, a type II PAK, is mutated in 16-18% of all melanomas. Melanoma-associated PAK7 mutations occur throughout the gene and have unknown biochemical and physiological consequences. The objective of this study was to determine how tumor-associated PAK7 variants mechanistically contribute to melanoma initiation and progression. First, we characterized PAK7 protein expression in a panel of 39 melanoma cell lines and primary melanocyte cultures. PAK7 levels were similar in both tumorigenic and non-tumorigenic cells and failed to correlate with the status of common melanoma driver mutations (e.g. NRASQ61, BRAFV600). In an array of 101 human tumor biopsies, PAK7 expression did not significantly change with advancing melanoma stage; however, PAK7 levels were higher in regional lymph node biopsies when compared to primary skin lesions. Since mutation is the predominant mechanism affecting PAK7 in melanoma, we investigated the biochemical and physiological consequences of common PAK7 variants. 11 distinct PAK7 mutations were stably expressed at low levels in VMM39 (melanoma) and NCI-H441 (lung) cells. Using these clones, changes in the phosphorylation of downstream PAK7 targets associated with cellular migration (p120), proliferation (CRAF), and apoptotic resistance (BAD, MDM2) were examined. In addition, we defined phenotypic alterations in cellular morphology, proliferation, migration, and apoptotic resistance associated with the expression of each mutant. These data allowed us to classify PAK7 variants of unknown significance into groups associated with specific cellular outcomes. To our knowledge, this is the first study to functionally characterize a wide variety of melanoma-associated PAK7 mutations and represents a critical first step in understanding how this kinase contributes to tumor initiation and progression. Citation Format: Kyle M. LaPak, Michael A. Gross, Denny C. Vroom, Greg B. Lesinski, William E. Carson. Defining the role of PAK7 variants in melanoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 195.

Experimental efforts to meliorate the modality effect have included attempts to make the visual stimulus more distinctive. McDowd and Madigan (1991) failed to find an enhanced recency effect in serial recall when the last item was made more distinct in terms of its color. In an attempt to extend this finding, three experiments were conducted in which visual distinctiveness was manipulated in a different manner, by combining the dimensions of physical size and coloration (i.e., whether the stimuli were solid or outlined in relief). Contrary to previous findings, recency was enhanced when the size and coloration of the last item differed from the other items in the list, regardless of whether the "distinctive" item was larger or smaller than the remaining items. The findings are considered in light of other research that has failed to obtain a similar enhanced recency effect, and their implications for current theories of the modality effect are discussed.

The revelation effect is a phenomenon of recognition memory in which words presented for a recognition decision are more likely to be identified as previously studied if they are initially disguised and are then somehow revealed to the subject. The goal of the present experiments was to determine whether the revelation effect has similar or different influences on the conscious recollection of a previous encounter with a test item and on the feeling of familiarity evoked by a test item. The process-dissociation procedure (Experiment 1) and the remember/know procedure (Experiment 2) were used to achieve this goal. The main findings of these experiments were that revealing an item at test (1) increased the feeling of familiarity associated with that item, especially if it was not previously studied, and (2) decreased conscious recollection of previously studied items. These data narrow the range of potential explanations of the revelation effect.

In recent years methods have been developed to extract the seaward landfast ice edge from series of remote sensing images, with most of them relying on incoherent change detection in optical, infrared, or radar amplitude imagery. While such approaches provide valuable results, some still lack the required level of robustness and all lack the ability to fully automate the detection and mapping of landfast ice over large areas and long time spans. This paper introduces an alternative approach to mapping landfast ice extent that is based on coherent processing of interferometric L-band Synthetic Aperture Radar (SAR) data. The approach is based on a combined interpretation of interferometric phase pattern and interferometric coherence images to extract the extent and stability of landfast ice. Due to the low complexity of the base imagery used for landfast ice extraction, significant improvements in automation and reduction of required manual interactions by operators can be achieved. A performance analysis shows that L-band interferometric SAR (InSAR) data enable the mapping of landfast ice with high robustness and accuracy for a wide range of environmental conditions.

Sandhoff disease is an autosomal recessive, neurodegenerative disease involving the storage of brain ganglioside GM2 and asialo-GM2. Previous studies showed that caloric restriction, which augments longevity, and N-butyldeoxynojirimycin (NB-DNJ, Miglustat), an imino sugar that hinders the glucosyltransferase catalyzing the first step in glycosphingolipid biosynthesis, both increase longevity and improve motor behavior in the beta-hexosaminidase (Hexb) knockout (-/-) murine model of Sandhoff disease. In this study, we used a restricted ketogenic diet (KD-R) and NB-DNJ to combat ganglioside accumulation. Adult Hexb-/- mice were placed into one of the following groups: (i) a standard diet (SD), (ii) a SD with NB-DNJ (SD + NB-DNJ), (iii) a KD-R, and (iv) a KD-R with NB-DNJ (KD-R + NB-DNJ). Forebrain GM2 content (mug sialic acid/100 mg dry wt) in the four groups was 375 +/- 15, 312 +/- 8, 340 +/- 28, and 279 +/- 26, respectively, indicating an additive interaction between NB-DNJ and the KD-R. Most interestingly, brain NB-DNJ content was 3.5-fold greater in the KD-R + NB-DNJ mice than in the SD + NB-DNJ mice. These data suggest that the KD-R and NB-DNJ may be a potential combinatorial therapy for Sandhoff disease by enhancing NB-DNJ delivery to the brain and may allow lower dosing to achieve the same degree of efficacy as high dose monotherapy.

When a sequence of visual stimuli is presented in a fixed location, immediate serial recall of the sequence is characterized by only a small recency effect. According to Battacchi, Pelamatti, and Umiltà (1990), the distribution of visual stimuli over space, as well as time, greatly enhances the recency effect. After an initial failure to find a strong visual recency effect with distributed presentation (Experiment 1), in the remaining experiments an attempt was made to more closely approximate Battacchi et al.'s methodology by eliminating articulatory suppression (Experiments 2-7), using their stimuli (Experiments 3-7), blocking conditions (Experiments 4-7), requiring written rather than typed responses (Experiments 5-7), and using their list length (Experiments 6 and 7). Nevertheless, even when their method was followed as closely as possible (Experiment 7), distributed presentation did not produce a strong visual recency effect. The influence of distributed presentation on the visual recency effect would seem to be, at best, limited.

Bandicoots in the family Peroryctidae in New Guinea are widespread and relatively abundant, but little is known of their ecology. We present the first detailed study on the ecology of the kalubu bandicoot (Echymipera kalubu) and observations on Raffray’s bandicoot (Peroryctes raffrayanus), from mid-montane forest in Papua New Guinea. Both species were primarily nocturnal and utilised a range of habitats including those modified by human activity, although Raffray’s bandicoot was more frequently encountered in less disturbed areas. Male kalubu bandicoots were larger than females, with larger animals having larger short-term home ranges and evidence for intrasexual territoriality. Mean short-term home-range size was 2.8 ha (MCP, n = 10), with an estimated population density of ~85 animals km–2 in the study area. Female kalubu bandicoots attained sexual maturity at ~400 g and 67% of mature females were reproductively active with an average of 1.5 young per litter. Both species were hunted, but their density, rate of reproduction and use of modified habitats suggest that they were able to withstand current hunting levels.

Irrelevant speech disrupts immediate recall of a short sequence of items. Salame and Baddeley (1982) found a very small and nonsignificant increase in the irrelevant speech effect when the speech comprised items semantically identical to the to-be-remembered items, leading subsequent researchers to conclude that semantic similarity plays no role in the irrelevant speech effect. Experiment 1 showed that strong free associates of the to-be-remembered items disrupted serial recall to a greater extent than words that were dissimilar to the to-be-remembered items. Experiment 2 showed that this same pattern of disruption in a free recall task. Theoretical implications of these findings are discussed.

The word length effect refers to the observation that memory is better for short than for long words. The irrelevant speech effect refers to the finding that memory is better when items are presented against a quiet background than against one with irrelevant speech. According to Baddeley's (1986, 1994) working memory, these variables should not interact: The word length effect arises from rehearsal by the articulatory control process, whereas irrelevant speech reduces recall through interference in the phonological store. Four experiments demonstrate that, like articulatory suppression, irrelevant speech eliminates the word length effect for both visual and auditory items. These results (1) provide further evidence against the ability of working memory to explain the word length and irrelevant speech effects and (2) confirm a specific prediction of Nairne's (1990) feature model.

The purpose of the present research was to compare memory for an item with memory for the item’s source. Experiment 1 investigated discrimination between two external sources: each item in a list of words was spoken in either a male or a female voice. Subjects received a test of item recognition and a test of source monitoring at each of four delay intervals (immediate, 30 min, 48 h, 1 week). In contrast with previous research, no evidence of differential forgetting rates for item and source information was found. With delay intervals of 0 and 48 h, Experiment 2 replicated Experiment 1 while adding a reality monitoring condition that required discrimination between an internal (i.e., self-generated) and an external source. Subjects were better at making internal-external discriminations than at making external-external discriminations, but both types of source monitoring declined at the same rate as memory for the items themselves.