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Your search keyword '"De Ruvo, Valentino"' showing total 7 results
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7 results on '"De Ruvo, Valentino"'

2. Genotypic and phenotypic characterization of a cohort of patients affected by rod CNG channel-associated retinitis pigmentosa

Author

Colombo, Leonardo, primary, Bonetti, Gabriele, additional, Maltese, Paolo Enrico, additional, Iarossi, Giancarlo, additional, Ziccardi, Lucia, additional, Fogagnolo, Paolo, additional, De Ruvo, Valentino, additional, Murro, Vittoria, additional, Giorgio, Dario, additional, Falsini, Benedetto, additional, Placidi, Giorgio, additional, Martella, Salvatore, additional, Galantin, Eleonora, additional, Bertelli, Matteo, additional, and Rossetti, Luca, additional

Published
2024
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3. Effectiveness of a New Active Tear Substitute Containing 0.2% Hyaluronic Acid and 0.001% Hydrocortisone on Signs and Symptoms of Dry Eye Disease by Means of Low- and High-Tech Assessments.

Author

Fogagnolo, Paolo, Giannaccare, Giuseppe, Mencucci, Rita, Villani, Edoardo, Orfeo, Vincenzo, Aragona, Pasquale, De Ruvo, Valentino, Strianese, Alfonso, Quisisana, Chiara, Borselli, Massimiliano, Rossi, Costanza, Scalzo, Giovanna Carnovale, Postorino, Elisa Imelde, Azzaro, Claudia, Mercuri, Stefano, Lucarelli, Flavia, De Vitto, Chiara, Ferioli, Eleonora, Marelli, Luca, and Napolitano, Pasquale

Published
2024
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6. Enhanced recovery after surgery in colon and rectal surgery: identification of predictive variables of failure in a monocentric series including 733 patients

Author

Giovanni Guarneri, Riccardo Rosati, Andrea Vignali, Ugo Elmore, Paolo Parise, Valentino De Ruvo, Vignali, Andrea, Elmore, Ugo, Guarneri, Giovanni, De Ruvo, Valentino, Parise, Paolo, and Rosati, Riccardo

Subjects
Adult, Male, medicine.medical_specialty, Multivariate analysis, Colon, Rectum, 030230 surgery, Logistic regression, Colonic Diseases, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, medicine, Humans, Treatment Failure, ERAS, Laparoscopy, Enhanced recovery after surgery, Aged, Retrospective Studies, Aged, 80 and over, Series (stratigraphy), Frailty, medicine.diagnostic_test, business.industry, Recovery of Function, Length of Stay, Middle Aged, Colorectal surgery, Surgery, Logistic Models, Rectal Diseases, medicine.anatomical_structure, Adherence, 030220 oncology & carcinogenesis, Female, Predictive variables, Enhanced Recovery After Surgery, business
Abstract

To identify factors associated with early deviation and delayed discharge within an Enhanced Recovery after Surgery (ERAS) pathway. This is a retrospective review of prospectively collected data of consecutive patients who underwent laparoscopic or open colorectal surgery and managed with a standardized ERAS pathway between April 2015 and October 2018. ERAS items were assessed within 48h after surgery. Patients with early complications were excluded. The influence of factors on length of stay was calculated by univariate and multivariate analysis. A binary logistic regression was used to model a predicting score. Seven hundred and thirty-three patients met the inclusion criteria. Multivariate analysis showed that age ≥ 75years (P = 0.02), ASA score ≥ 3 (P = 0.03), open surgery or conversion to open (P = 0.001), non-compliance with the intra-operative balanced fluid therapy (P = 0.049), failure to early removal of the urinary catheter (P = 0.001), to discontinue IV fluid (P = 0.02) and to early mobilization (P = 0.001) were independently associated with ERAS failure. The generated score had a specificity of 84% and a positive predictive value of 72%. Patients who would have a length of stay longer than the median for each surgical procedure were properly identified (Area under ROC Curve = 0.753, P

Published
2020
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7. Genotypic and Phenotypic Characterization of a Cohort of Patients Affected by Rod Cyclic Nucleotide Channel-Associated Retinitis Pigmentosa.

Author

Colombo L, Bonetti G, Maltese PE, Iarossi G, Ziccardi L, Fogagnolo P, De Ruvo V, Murro V, Giorgio D, Falsini B, Placidi G, Martella S, Galantin E, Bertelli M, and Rossetti L

Subjects
Humans, Male, Female, Retrospective Studies, Middle Aged, Adult, Young Adult, Adolescent, Electroretinography, Tomography, Optical Coherence methods, Aged, Mutation, Child, Retinal Rod Photoreceptor Cells metabolism, Fluorescein Angiography methods, Genetic Association Studies, DNA Mutational Analysis, Pedigree, DNA genetics, Retinitis Pigmentosa genetics, Retinitis Pigmentosa diagnosis, Retinitis Pigmentosa physiopathology, Cyclic Nucleotide-Gated Cation Channels genetics, Visual Acuity, Phenotype, Genotype
Abstract

Introduction: Retinitis pigmentosa (RP), a heterogeneous inherited retinal disorder causing gradual vision loss, affects over 1 million people worldwide. Pathogenic variants in CNGA1 and CNGB1 genes, respectively, accounting for 1% and 4% of cases, impact the cyclic nucleotide-gated channel in rod photoreceptor cells. The aim of this study was to describe and compare genotypic and clinical characteristics of a cohort of patients with CNGA1- or CNGB1-related RP and to explore potential genotype-phenotype correlations., Methods: The following data from patients with CNGA1- or CNGB1-related RP, followed in five Italian inherited retinal degenerations services, were retrospectively collected: genetic variants in CNGA1 and CNGB1, best-corrected visual acuity (BCVA), ellipsoid zone (EZ) width, fundus photographs, and short-wavelength fundus autofluorescence (SW-AF) images. Comparisons and correlation analyses were performed by first dividing the cohort in two groups according to the gene responsible for the disease (CNGA1 and CNGB1 groups). In parallel, the whole cohort of RP patients was divided into two other groups, according to the expected impact of the variants at protein level (low and high group)., Results: In total, 29 patients were recruited, 11 with CNGA1- and 18 with CNGB1-related RP. In both CNGA1 and CNGB1, 5 novel variants in CNGA1 and 5 in CNGB1 were found. BCVA was comparable between CNGA1 and CNGB1 groups, as well as between low and high groups. CNGA1 group had a larger mean EZ width compared to CNGB1 group, albeit not statistically significant, while EZ width did not differ between low and high groups A statistically significant correlation between EZ width and BCVA as well as between EZ width and age were observed in the whole cohort of RP patients. Fundus photographs of all patients in the cohort showed classic RP pattern, and in SW-AF images an hyperautofluorescent ring was observed in 14/21 patients., Conclusion: Rod CNG channel-associated RP was demonstrated to be a slowly progressive disease in both CNGA1- and CNGB1-related forms, making it an ideal candidate for gene augmentation therapies., (© 2024 The Author(s). Published by S. Karger AG, Basel.)

Published
2024
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