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46 results on '"De Blasi M"'

4. Untersuchung zur Festlegung von Grenzwerten der optisch-spektralen Transmissionsbildgebung (HandScan) bei Patienten mit rheumatoider Arthritis unter Berücksichtigung von Störfaktoren

Author

Triantafyllias, K, Altamimi, K, De Blasi, M, and Schwarting, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die ersten Daten zur optisch-spektralen Transmissionsbildgebung bzw. OST (HandScan) ergaben sowohl Korrelationen mit klinischen und arthrosonographischen Aktivitätsmarkern bei Patienten mit rheumatoider Arthritis (RA) als auch eine gute diagnostische Wertigkeit in der RA-Verlaufskontrolle[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021
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6. Janus Kinase-Inhibitoren bedingte Hyperlipidämie: Assoziation mit einer Erhöhung der aortalen Steifigkeit bei Patienten mit Arthritis?

Author

Triantafyllias, K, Thiele, LE, De Blasi, M, and Schwarting, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Therapie mit Janus Kinase-Inhibitoren (JAK-i) kann zu einer Lipiderhöhung bei Patienten mit Arthritis führen [ref:1]. Allerdings können JAK-i zur Reduktion der systemisch-entzündlichen Aktivität beitragen und somit positiv auf das cardiovaskuläre (CV)-System[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Published
2020
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7. Diagnostische Wertigkeit der Thermographie bei Carpitis: Renaissance der Thermographie? Erste Ergebnisse einer explorativen retrospektiven Studie

Author

Clasen, M, Triantafyllias, K, De Blasi, M, Nikolodimos, E, and Schwarting, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Erfassung von entzündlichen Veränderungen im Rahmen von systemisch-entzündlichen rheumatischen Erkrankungen ist sehr wichtig, um eine optimale Behandlung zu gewährleisten. Das Ziel dieser Forschungsarbeit ist es, den potentiell nützlichen Einsatz einer Infrarot-Kamera[zum vollständigen Text gelangen Sie über die oben angegebene URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2019
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8. Diagnostische Wertigkeit der optisch-spektralen Transmissionsbildgebung (HandScan) bei Patienten mit Rheumatoider Arthritis: erste deutsche Daten

Author

Triantafyllias, K, Heller, C, De Blasi, M, and Schwarting, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Um den zerstörenden Prozess der Rheumatoiden Arthritis (RA) möglichst zu verhindern, ist der Rheumatologe auf zuverlässige diagnostische Maßnahmen angewiesen. Die neue Technik des Hemics-HandScans, die sogenannte optisch-spektrale Transmissionsbildgebung (OST), verspricht[zum vollständigen Text gelangen Sie über die oben angegebene URL], 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2019
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15. Imitare, ‘invenire’, rendere presente: la riflessione estetica a fondamento del fare artistico manzoniano

Author

Battistini, L, Caputo, V, De Blasi, M, Liberti, GA, Palomba, P, Panarella, V, Stabile, A, Bisi, Monica, Monica Bisi (ORCID:0000-0001-8743-5821), Battistini, L, Caputo, V, De Blasi, M, Liberti, GA, Palomba, P, Panarella, V, Stabile, A, Bisi, Monica, and Monica Bisi (ORCID:0000-0001-8743-5821)

Abstract

La produzione letteraria di Manzoni trova fondamento nelle riflessioni di carattere teoretico (ed estetico) che l’autore le affianca a partire dagli abbozzi degli anni Dieci raccolti nei «Materiali estetici» fino alle più complesse dissertazioni del dialogo «Dell’invenzione». Sono riflessioni sul fine, i mezzi, il senso, l’essenza, insomma, del fare arte e dell’essere artista, che, fin dagli esordi, Manzoni elabora in dialogo con insigni modelli: il contributo si sofferma in particolare sui debiti che l'autore contrae con Schlegel e con Humboldt, mediati da Fauriel, la cui lezione, arricchita ma non tradita nel corso del tempo, testimonia della famigliarità di Manzoni con la cultura tedesca già durante gli anni del suo soggiorno parigino.

Published
2018

16. «L’arte d’Apelle, e Fidia, / e le Dedalee destre / ponno a i Cigni d’Italia esser maestre». L’esempio delle arti figurative nella 'Poetica sacra' di Giovanni Ciampoli

Author

Battistini L., Caputo V., De Blasi M., Liberti G. A., Palomba P., Panarella V., Stabile A., Apollonio, Silvia, Apollonio Silvia (ORCID:0000-0001-9476-0366), Battistini L., Caputo V., De Blasi M., Liberti G. A., Palomba P., Panarella V., Stabile A., Apollonio, Silvia, and Apollonio Silvia (ORCID:0000-0001-9476-0366)

Abstract

Nella 'Poetica sacra' (III trattato del I libro) Ciampoli condensa alcuni dei nuclei più rilevanti della sua argomentazione intorno alla poesia da rifondare: insieme alla definitiva convalida della materia sacra come argomento poetico si propone il parziale recupero delle favole antiche. La comunicazione intende illustrare i luoghi in cui Ciampoli invita i poeti a servirsi di esempi tratti dalle arti figurative e aggiunge l’osservazione diretta di opere artistiche romane (ad es. la fontana dell’Acqua Felice).

Published
2018

17. A 36 mu W Rail-to-Rail-Input Chopper Stabilized Amplifier using Correlated Double Sampling

Author

Pipino, A, De Blasi, M, De Matteis, M, D'Amico, S, Fornasari, A, Baschirotto, A, Pipino, A, De Blasi, M, De Matteis, M, D'Amico, S, Fornasari, A, and Baschirotto, A

Subjects
modulation, Miller compensation, chopper technique, CDS
Abstract

This paper describes a chopper stabilized amplifier, obtained using an input chopper for modulation, an AC coupling for offset rejection and a correlated double sampling structure for demodulation, avoiding ripple spurs. The operational amplifier has a rail-to-rail input stage, with a supply voltage range from 1.8V to 5V. It is characterized by a multipath nested Miller compensation network with double pole-zero cancellation. The circuit achieves a simulated 130dB-dc-gain with a current consumption of 20 mu A, suitable for low-power application. Equivalent input offset has been evaluated by Montecarlo simulations demonstrating a maximum standard deviation of about 4 mu V.

Published
2013

18. A 36μW rail-to-rail-input chopper stabilized amplifier using correlated double sampling

Author

Pipino A., De Blasi M., De Matteis M., D'Amico S., Fornasari A., Baschirotto A., Pipino, A., De Blasi, M., De Matteis, M., D'Amico, S., Fornasari, A., and Baschirotto, A.

Subjects
Modulation, Chopper technique, Miller compensation, CDS
Abstract

This paper describes a chopper stabilized amplifier, obtained using an input chopper for modulation, an AC coupling for offset rejection and a correlated double sampling structure for demodulation, avoiding ripple spurs. The operational amplifier has a rail-to-rail input stage, with a supply voltage range from 1.8V to 5V. It is characterized by a multipath nested Miller compensation network with double pole-zero cancellation. The circuit achieves a simulated 130dB-dc-gain with a current consumption of 20μA, suitable for low-power application. Equivalent input offset has been evaluated by Montecarlo simulations demonstrating a maximum standard deviation of about 4μV. © 2013 IEEE.

Published
2013

19. Sigma-delta ADC based adaptive readout ASIC for digital audio sensor

Author

Zou, L, Rocca, G, De Blasi, M, Grassi, M, Malcovati, P, Baschirotto, A, Zou, L, Rocca, G, De Blasi, M, Grassi, M, Malcovati, P, and Baschirotto, A

Abstract

Digital audio sensors have been used in microphone-embedded portable electronics. This paper shows a mixed-signal adaptive readout ASIC for digital audio sensor, which includes a programmable-gain-amplifier, a switched-capacitor sigma-delta modulator, digital signal processing, and power management circuits. The digital part comprises a digital low-pass filter, a digital-gain-compensation and a digital automatic-gain-controller. The clear advantage of this system is to obtain high signal-to-noise ratio (SNR) and wide input range simultaneously. In addition, both a normal operation mode and a sleep mode are realized to address a flexible current budget. The ASIC is fabricated in a 0.18-um CMOS process. Experimental results show the expected adaptive readout function over the input range from 94 to 136Â dB SPL. In the normal mode, a system SNR of 68Â dB (A-weighted) at 1Â kHz 94Â dB SPL input is achieved under 600Â uA. Further, an impressive acoustic overload point (AOP) of 136Â dB SPL is guaranteed. In the standby condition, the sleep mode with current less than 20Â uA is obtained, so that the battery life can be extended. Compared to other existing solutions, this adaptive readout ASIC shows the best combination of achievable SNR, AOP and current budget for digital audio sensors.

Published
2017

21. Fully integrated triple-mode sigma-delta modulator for speech codec

Author

Zou, L, De Blasi, M, Rocca, G, Grassi, M, Malcovati, P, Baschirotto, A, BASCHIROTTO, ANDREA, Zou, L, De Blasi, M, Rocca, G, Grassi, M, Malcovati, P, Baschirotto, A, and BASCHIROTTO, ANDREA

Abstract

Mixed-signal speech processing system has been used in microphone-embedded portable electronics. Speech codec is the core of such a system. In speech codecs, sigma-delta modulator is one key block which converts analog voice signal into pulse density modulation (PDM) output for further digital signal processing. This paper shows the design of a triple-mode switched-capacitor sigma-delta modulator for speech codec. High mode (20 kHz signal bandwidth), low mode (4 kHz signal bandwidth), and sleep mode are implemented by addressing a flexible operation current. In order to realize a fully integrated solution, power management circuits dedicated to the modulator are also implemented, which includes frequency detector, LDO, bandgap and reference voltage buffers. The ASIC is fabricated in a 0.18-um CMOS process. In high mode measurement, an A-weighted signal-to-noise ratio (SNR) of 78 dB with -2.5 dBFS input is achieved under 138 uA. In low mode measurement, an SNR of 78 dB with -2 dBFS is achieved under 100 uA. In the standby condition, a sleep mode with current less than 10 uA is realized, so that the battery life is extended.

Published
2016

23. A 255 MHz Programmable Gain Amplifier and Low-Pass Filter for Ultra Low Power Impulse-Radio UWB Receivers

Author

D'Amico, S, De Blasi, M, DE MATTEIS, M, Baschirotto, A, DE MATTEIS, MARCELLO, BASCHIROTTO, ANDREA, D'Amico, S, De Blasi, M, DE MATTEIS, M, Baschirotto, A, DE MATTEIS, MARCELLO, and BASCHIROTTO, ANDREA

Abstract

A 90 nm-CMOS power-optimized analog baseband chain for ultra-low-power impulse-radio ultra-wideband (IR-UWB) receivers is presented. The proposed device merges the functions of a programmable gain amplifier (PGA) and a low-pass filter (LPF). It consists of the cascade of three biquadratic cells made up by opamps in a series-shunt configuration, which features high input impedance, low load effects in the cascade blocks, and better frequency response. The opamp parameters are included in the overall biquad transfer function. This allows getting very low power performance, since the opamp bandwidth is not required to be much larger than the filter cutoff frequency. Moreover, the current consumption is optimized according to the selected gain level (1.3 mA at 0 dB-gain up to 1.9 mA at 40 dB-gain). The PGA features a 0-40 dB programmable gain range with a 5 dB gain-step. The LPF performs a sixth-order 255 MHz low-pass frequency response. For the overall chain the IIP3 is 14 dBm at 0 dB gain, while the input referred noise is 12.5 nV/√Hz at 40 dB gain. © 2012 IEEE.

Published
2012

24. Intravenous NPA for the treatment of infarcting myocardium early; InTIME-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction

Author

Braunwald, E., Neuhaus, K. -L., Antman, E., Chew, P., Skene, A., Wilcox, R., Ambrosioni, E., Anderson, J., Apetrei, E., Bata, I., Carrageta, M., Col, J., Dalby, A., Davies, R., Deckers, J., Eichman, D., Grande, P., Greene, R., Gurfinkel, E., Heikkilä, J., Henry, T., Hillis, D., Hochman, J., Huber, K., Kostis, J., Klinke, P., López-Sendón, J., Mckendall, G., Móller, B., Moore, P., Morris, A., Mueller, H., Östör, E., Oto, A., Ruda, M., Sadowski, Z., Schweiger, M., Sequeira, R., Shah, P., Shannon, R., Smith, B., Sobel, B., Steingart, R., Tebbe, U., Toman, J., Traboulsi, M., Vahanian, A., Warnica, J. W., Willerson, J., Deitchman, D., Davidson, L., Folgia, T., Foxley, A., Goodman, J., Hauck, C., Henry, D., Mccabe, C., Pangerl, A., Thomson, A., Wagner, M., Kennedy, J. W., Cairns, J., Demets, D., Julian, D., Simoons, M., Charlesworth, A., Easton, J. D., Ferbert, A., Feske, S., Kuhn, P., Moseley, J., Rogg, J. M., Reichmann, H., Sloan, M., von Kummer, R., Zamani, A., Coulter, S., Giugliano, R., Skene, A. M., Ardill, R., Ince, Y., Peters, A., Ward, K., Wolf, L., Curtis, N., De Brés, J., Stead, S., Watson, S., Cutler, S., Friedman, J., Helfrick, R., Williams, S., Klimovsky, J., Kumagai, S., Adams, E., Anderson, C., Bauhuber, I., Bennett, L., Biro, E., Boyce, E., Bregman, B., Carvalho, P., Ciganovic, D., Csukas, M., Cuenca, P., De Cuyper, S., Diez, P., Dijkhuizen, M., Dille-Amo, C., Gonzalez-Santis, A., Gursoy, M., Hammarstrom, K., Harasta, E., Ingman, E., Kelemen, B., Keulen, I., Koren, A., Langthaler, G., Lemaire, F., Little, I., Montalban, C., Nijssen, K., Neumueller, I., Palander, M., Pekuri, T., Persson, U., Pilz, J., Oudotova, S., Pisklakov, V., Proinov, F., Ptaszynska, A., Read, J., Retei, S., Romeyer, F., Romanini, M., Saar, L., Salein, D., Samsonov, M., Simeon-Dubach, D., Simmonds, J., Skaza, M., Skvortsova, N., Smidlova, Z., Spitzerova, H., Strijdveen, I., Szajewski, T., Ugurnal, B., Valcarce, M., van Rompaey, I., Walker, A., Zak, E., Zimova, N., Barrero, C., Beck, E., Bruno, M. L., Caccavo, A., Cagide, A., Campo, A., Cermesoni, R., Chahin, M., Dutra, O., Estrada, J., Falu, E. A., Gagliardi, J., Garre, L. E., Liprandi, A. S., Luciardi, H., Mautner, B., Muntaner, J., Nau, G., Salzberg, S., Santopinto, J., Sinisi, A., Torres, H., Eber, B., Elliott, P., Hiemetsberger, H., Juhasz, M., Kühn, P., Leisch, F., Niktardjam, M., Reisinger, J., Schmalix, G., Schuster, R., Sihorsch, K., Silberhauer, K., Slany, J., Steinbach, K., Tragl, K. H., Valentin, A., Al Shwafi, K., Dasnoy, P., De Clippel, M., de Meester, A., De Raedt, H. J. L. P., Emonts, M., Evrard, P., Eycken, M., Geboers, M., Heyndrickx, G., Lauwers, K., Mitrie, K., Pirenne, B., Renard, M., Somers, Y., Timmermans, P., Van Kuyk, M., Van Mieghem, W., Vermeulen, J., Verrostte, J. M., Albuquerque, D., Ayoub, J. C. A., Carvalho, A., Cesar, L., Gebara, O., Golin, V., Knobel, E., Leaes, P., Neto, J. A. M., Nicolau, J. C., Piegas, L. S., Rabelo, A., Rassi, A., Sila, L., Simao, A. F., Ashton, T., Baillie, H., Bhargava, R., Bota, G., Cameron, W., Chan, N., Chan, Y. K., Daly, P. A., Darcel, I., Davies, E., Desjardin, L., Dhingra, S., Ducas, J., Ervin, F. L., Fortin, C., Fowlis, R., Fulop, J., Furey, M., Gagnon, S., Gebhardt, V., Giannaccro, P., Gosselin, G., Graham, J., Grondin, F., Heath, J. W., Henderson, M., Hilton, D. R., Hiscock, J., Hui, W., Kaza, L., Kesselman, T., Kouz, S., Kucerak, M., Lahoude, N., Lamothe, M., Lebouthillier, P., Lenis, J., Levesque, P., Lopez, J. F., Lubelsky, B., Macritchie, D., Mayer, J. -P., Mcdowell, J. D., Montigny, M., Orestien-Lyall, T., Parekh, P., Pistawka, K., Price, J. B., Pruneau, G., Quinn, B., Reid, B. R., Richmond, M., Rose, B., Schuld, R., Sharma, N. K., Shetty, P., Stanton, E., Strauss, H. D., Sussex, B., Theroux, P., Turabian, M., Turner, C., Vizel, S., Walker, M., Weeks, A., Winkler, L., Zacharias, G., Zimmerman, R., Bartolucci, J., Castro, P., Diaz, M. A., Illanes, G., Potthoff, S., Sanchez, E. C., Silva, L. M., Yovanovich, J., Zanetti, F. L., Alan, D., Balázová, K., Boček, P., Cerny, J., Fischerova, B., Holub, M., Hradec, J., Janota, T., Janský, P., Kasper, J., Klimsa, Z., Motovská, Z., Pleva, L., Pluhacek, L., Pšenčka, M., Semrád, B., Spinar, J., Staněk, V., Štípal, R., Suítil, P., Vítovec, J., Wichterie, D., Widimský, P., Zeman, K., Andersen, C. B., Kriegbaum, J., Nielsen, N., Nielsen, P. E., Schou, J. B., Teesalu, R., Voitk, J., Haapamäki, H. V. H., Halkosaari, M., Härkönen, M., Jägerholm, S., Kärjä-Koskenkari, P., Karthunen, P., Kesäniemi, Y. A., Koskivirta, H., Lehto, P., Lilja, M., Paakkinen, S., Palomäki, A. K., Pietilä, K., Tuominen, J., Viopio-Pulkki, L., Ylönen, H., Adi, I., Admant, P., Akadirik, A., Alagha, Z., Alhabaj, S., Amat, G., Andre, A. A., Apffel, F., Aswad, K., Baradat, G., Bareiss, P., Barthers, F. B., Baudet, M., Baudouy, M., Bearez, E. M., Berthou, J. D., Berzin, B., Bessede, G., Blanc, J. J., Bocara, A., Bonneau, A., Bourdad, C., Bouvier, J. M., Cassagnes, J., Cassat, A., Cazaux, P., Charbonnier, B., Clementy, J., Cohen, A., Coisne, D., Colin, P., Croizier, O., D’Hautefeuille, B., D’Ivernois, C., Daumas, P. L., Dauphin, C. L., Deforet, M. F., Degand, B., Dequeker, J. L., Dickele, M. C., Dugrand, P., Durand, S., Ebagosti, A., Elharrar, C., Equine, O., Fichter, E., Flork, L., Fouche, R., Fourchard, V., Fourme, T., Fournier, P. Y., Funck, F., Galley, D., Garbarz, E., Ghadban, W., Gladin, M., Grall, J. Y., Grand, A., Gryman, R., Guillard, N., Guillo, P., Haftel, Y., Hannebicque, G., Henry, R., Huret, J. F., Janin-Magnificat, L., Jarnier, J., Joly, A., Kamal, H., Khalife, A., Roynard, J. L., Lang, M., Lapeyssonnie, A., Ledain, L., Lejeune, P., Lemetayer, L., Lepori, R., Lombart, A., Lusson, J. R., Magnin, O., Marquand, A., Martelet, M. M., Martelli, A., Mathurin, C., Mentre, B., Messager, D., Morizot, M., Mouallem, M. J., Mouhoub, O., Mycimski, C., Nallet, O., Olive, T., Pacouret, G., Palcoux, M. C., Poulard, J. E., Pruvost, A., Quiret, J. C., Richard, C., Richard, P., Rickaud, P., Riehl-Aleil, V., Rifai, A., Rocher, R., Rotreff, P., Segrestin, B., Slama, M. S., Sultan, P., Tabone, X., Talbodec, A., Tissot, M. T., Toussaint, C., Veyrat, A., Zerrouk, Z., Adamczak, M., Altmann, E., Altybernd, B., Andreassen, G., Andresen, D., Appenrodt, H., Bachmann, S., Bäcker, U., Beckert, U., Behr, H. M., Beier, W., Beier, T., Berger, D., Bernsmeier, R., Beythien, R. D., Biechl, E., Biedermann, G., Bischoff, K. O., Blerich, J., Boch, H. B., Bonzel, T., Both, A. R., Breidenbach, K., Breuer, M., Breuer, H. W. M., Brunkhorst, F. B., Bruns, A., Bundschu, H. D., Burkhardt, W., Busse, H. J., Caesar, K., Cailloud, J., Chlosta, A., Chorlanopoulos, E., Consemüller, S., Decker, W., Dichgans, M., Dick, R., Diederich, K. W., Dienst, C., Dietz, A., Dißmann, R., Ditter, H., Doering, W., Drost, H., Dundalek, E. D., Eckardt, D., Edelmann, A., Eggeling, T., Eggert, G., Eichner, R., Endres, C., Engberding, R., Engel, H. J., Faehnrich, A., Fischer, J. L., Flor, A., Forycki, F. Z. F., Froböse, H. J., Fruehauf, T., Fuchs, M., Geiser, R., Geletneky, J., Gerdes, H., Gerecke, B., Gesing, S., Gieser, H., Girth, E., Glogner, P., Glover, M., Goetz, J., Goetz, H., Göttfert, G., Gottwik, M., Gregori, B., Grieshaber, M., Großmann, C., Gruber, G., Gunold, H., Häßler, W. H., Hackenjos, B., Hader, O., Hamer, H., Harmjanz, D., Hasst, G., Haun, H., Hauptmann, K. E., Hegge, F. J., Heinze, A., Heinze, R., Henrichs, K. J., Hergenröther, H., Herrmann, F., Herzig, C., Hey, D., Hill, S., Hinzmann, S., Hoffmann, S., Höfs, T., Höhler, H., Holle, G., Höltman, B. J., Horacek, T., Hossmann, V., Hübner, F. S., Hülskamp, C., Hunecke, R., Hust, M., Jaeckh, G., Jebens, C., Jennen, E., Jost, M., Justiz, R., Kallmann, L., Kalscheur, F., Kaschner, W., Kaspar, W., Kauder, E., Keitel, B., Keller, H., Kemkes, T., Kerler, N., Kester, M., Kettner, W., Kilp, M., Kirklies, A., Klaus, A., Klein, H. H., Klenböck, J. R., Kley, H. K., Klingenbeck, R., Koch, H., Kohler, B., Kohler, J., Kolloch, R., Konermann, M., Körber, H. G., Kother, T. K., Kötter, V., Kottwitz, B., Kozariszcsuk, G., Kracht, T., Kratzsch, G., Kreft, H. U., Kreuter, G., Krönert, H., Krönig, B., Krueger, E., Krülls-Münch, J., Kuckuk, H., Kuelschbach, M., Kuhrt-Lassay, O. W., Kummerhoff, P. W., Kunevt, R., Kurth, C. U., Lang, C., Lange, C., Langhoff, R., Laskus, A., Lazarus, P., Lehmann, H. U., Lenga, P., Lengfelder, W., Leupolz, W., Limbourg, P., Loos, U., Lucanus, W., Machill, K., Mäckel, P., Mackes, K. G., Maier, S., Makowski, B., Mandok, J., Manz, M., Mäurer, W., Meier, F., Meier, J., Menges, M., Merx, W., Meurers, G., Michels, U., Mickeler, C. H., Mons, D., Moos, E., Mueller, R., Müller, G., Nast, H. P., Naumann, G., Nebelsieck, H., Neubaur, J., Niederer, W., Nitsch, J., Noack, J., Nogai, K. F. W., Oberheiden, A., Obst, R., Ochs, H. R., Odemar, F., Odenthal, H. J. B., Offers, E., Öhl, S., Ohlmeier, H. A. R. M., Patzer, P., Pech, A., Peters, U., Petry, U., Pietschmann, G. J., Pistner, W., Plappert, B., Pohlmann, W. K., Pollock, B., Presser, H. J., Przytarski, K., Puerner, K. L., Raouf, N., Reike, N., Reil, G. H., Reinhard, U., Riebeling, V., Ritzmann, M., Rödder, J., Roth, E., Rüdelstein, R., Saborowski, F., Sauter, B., Sceffler, N., Schartl, A., Schifferdecker, E., Schlotterbeck, K. P., Schmidt, J., Schmidt-Dannert, D. R., Schmidt-Klewitz, H., Schmitz, H. J., Schnebelt, T., Schneider, H. L., Schneider, F. J., Schoeller, R., Scholz, D., Schoppe, W. D., Schreiner, G., Schroeder, J., Schuh, N., Schulte, K. L., Schulze, H., Schulze, H. D., Schuster, P., Schuster, H. P., Schweizer, P., Sechtem, U., Sedlmaier, H. P., Segel, S., Sehnert, W., Seidel, F., Siedentopf, K., Simon, H., Sodomann, C. P., Solbach, C., Sorges, E., Stabenow, S., Stadler, K. P., Stammwitz, E., Stein, U., Sternberg, H., Stiepak, C., Stockmann, M., Straus, W., Striegel, H., Struch, E., Strupp, G., Taubert, T. B. 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A., Zwirner, K., Becker, D., Bosko, M., Csillag, I., Ermenyi, A., Fogas, J., Heltai, K., Jánosi, A., Katona, A., Kiraly, C., Kiss, B., Kutor, G., Mizik, R., Molnar, T., Mühl, M., Nagy, D., Palacti, I., Rudas, L., Sárosi, I., Simon, K., Sitkel, E., Sydó, T., Szaboki, F., Szikla, K., Szönyi, T., Timar, S., Vándor, L., Zamolyl, K., Walsh, M., Caspi, A., Swissa, M., Badano, L., Baldacci, G., Balli, E., Banda, D., Baretta, G., Boccalatte, A., Borgatti, M. L., Branzi, A., Burelli, C., Capelletti, D., Capucci, A., Caragiulo, D., Carbonieri, E., Cassin, M., Ceci, V., Cocchieri, M., Coletta, C., Conte, E., Contini, G. M., Corsini, G., D’Annunzio, E., De Blasi, M., De Luca, I., Delciterna, F., Di Pasquale, G., Diguardo, G., Fattore, L., Ferraiuulo, G., Finardi, A., Fioretti, P. M., Giunta, G., Guiducci, U., Guzzardi, G., Horando, G., Ignone, G., Lazzaroli, A., Levantesi, D., Liberati, R., Losi, E., Macor, F., Mangiameli, S., Martines, C., Meinardi, F., Morgera, T., Morozzi, L., Mostacci, M., Naccarella, F. F., Ottani, F., Palamara, A., Pani, A., Paperini, L., Pes, R., Pesola, A., Porzio, A., Raviele, A., Ricci, S., Rosi, A., Rossi, R., Rotiroti, D., Rusconi, L., Sabino, G., Saccone, V., Sanna, A., Scaramuzzino, G., Scorcu, G. P., Semprini, F., Severini, D., Staniscia, D., Tantalo, L., Tartagni, F., Terrosu, P., Tondelli, S., Trichero, R., Uslenghi, E., Vajola, S. F., Vetrano, A., Violi, E., Zardini, P., Zingarini, G. L., Zobbi, G., Zuin, G., Kalnins, U., Cârvekülg, A., Laanoca, J., Iacis, J., Lankiene, L., Laucevicius, A., Lukoseviciute, A., Palsauskaite, R., Petrauskiene, B., Soopóld, W., Uuetoa, H., Vilks, J., Vitonyte, R., Zakke, I., Dorantes, J., Hernández, H., Jerjes, C., Leva Garza, J. L., Martinez, C., Anneveldt, A., Baars, H. F., Baldew, S. C., Bendermacher, P. E. F., Boersma, L. V. A., Bos, R. J., Breedveld, R. W., Bruggink, P. W. F., Ciampricotti, R., Darmanata, J. I., de Porto, A. E., de Weerd, G. J., Deckers, J. W., Freericks, M. P., Hillebrand, F. A., Kerker, J. P., Koenen, J. C., Kofflard, M. G. M., Liem, K. L., Liem, A. H., Linssen, G. C. M., Lionarons, R. J., Peters, J. R. M., Posma, J. P., Saat, E. W. M., Savalle, L. H., Smits, W. C. G., Suttorp, M. J., Tans, A. C., Troquay, R. P. Th., van Beek, G. J., van Boven, A. J., Van der Heijden, R., Van Hessen, A., van Langeveld, R. A. M., van Lier, T. A. R., van Loo, L. W. H., van Wijngaarden, J., van Ziejl, L. G. P. M., Veerhoek, M. J., Vermer, F., Werner, H. A., Graven, T., Klykken, B., Meyerdieks, O., Omland, T. M., Otterstad, J. E., Pedersen, T., Rød, R., Banaszewski, M., Bednarkiewicz, Z., Bojarski, G., Ceremuzyñski, L., Czestochowska, E., Gajewski, M., Galewicz, M., Gorski, J., Grabczewska, Z. S., Gruchaka, M., Janicki, K., Janion, M., Jaworska, K., Jezewska, M., Kakol, J., Kizciuk, M., Kleinrok, A., Kolodziej, P., Komorowski, P., Konopka, A., Kopaczewski, J., Korecki, J., Kornacewicz-Jach, Z., Kowalewski, M., Kratochwil, D., Krolczyk, J., Krzminska-Pakula, M., Kurek, P., Kurowski, M., Kurpesa, M., Kurzawski, J., Kwiecien, R., Lenartowski, L., Lewandowski, M., Loboz-Grudzieñ, K., Luczak, G., Maliñski, A., Michalski, M., Musial, W., Nartowicz, E., Nowicka, A., Odyniec, A., Pasyk, S., Prastowski, W., Przybylski, A., Raczynska, A., Rodzik, J., Romanowski, M., Rynkiewicz, A., Rzyman, M., Sidorowicz, A., Sledziona, M., Sobiczewski, W., Sobkowicz, B., Sobolewska, J., Sokalski, L., Stepinska, J., Sterlinski, M., Stopinski, M., Świątecka, G., Szpernal, Z., Tarnowska, H., Trzos, E., Ujda, M., Wierzchowiecki, M., Wodynska, T., Wojciechowski, D., Wrabec, K., Wrzesinski, K., Zuk, P., Albuquergue, A., Costa, A., Cunha, D., Ferreira, D., Ferreira, R., Gaog Leiria, J. M., Pimenta, A., Rufino, E., Vasconcelos, J., Aldica, M., Balanescu, S., Bruckner, I. V., Capalneanu, R., Florescu, N., Georgescu, C. S., Cherasim, L., Ginshina, C., Merenta, A., Parvu, O., Radutiu, S., Savulescu, I., Vita, I., Averkov, O., Bokarev, I. N., Gratsiansky, N., Grigoriev, Y., Gruzdev, A., Kakhnovsky, I., Kheevehuk, T. V., Khrustalev, O., Kobalava, Y., Konoratieva, T. B., Koukline, Vladimir, Martiouchov, S., Pavlikova, E., Poskotinov, I., Rogalev, K., Sinopainikov, A., Syrkin, A., Tereschenko, S. T., Yavelov, I., Zavolghin, S., Čurilla, E., Kohn, R., Kovář, F., Murín, J., Poliačik, P., Drinovec, I., Horvat, M., Krivec, B., Markež, J., Pareznik, R., Pehnec, Z., Resman, J., Sifrer, F., Skale, R., Trinkaus, D., Voga, G., Baig, M. M. E., Blomerus, P., Botha, B. P., Burgess, L., Duncan, D., Duncan, D. I., Gillmer, D., Govender, N., Jardine, R. J., Kok, A., Manga, P., Naidu, R. K., Rajput, M. C., Ranjith, N., Roos, J. S., Snyders, F. A., Steingo, L., Stern, A., Tayob, F. Z., Vythilingum, S., Alonso-Orcajo, N., Arribas Jimenez, A., Ayestaran, J. I., Balsera, B. B. G., Barras, C., Castro, A., Cobo, N., Duque, A., Garcia, M. J., Goiriena, P., Gonzalez-Valdayo, M., Gulias Lopez, J. M., Jimenez Gomez, P., Lopez Garanda, V., Martín Santos, F., Nogueira, R., Pabon Osuna, P., Ponce De Leon, E., Quesada Dorador, A., Paya Serrano, R., Rodriguez, L., Rodriguez, M., Rubio, F., Ruiz-Salmeron, R., Solar, J., Toquero, J., Velasco, J., Vilar Herrero, V., Vizcaino, M., Wancisidor, X., Basilier, E., Birgersdotter, V., Björnsdotter, E., Bjurman, A., Hagström, D., Hallin, I., Hansen, O., Hemmingson, L. O., Lundkvist, L., Lycksell, M., Möller, B., Nolgard, P., Sjölund, G., Stjerna, A., Angehrn, W., de Benedetti, E., Diethelm, M., Gallino, A., Plebani, G., Vögelin, H. P., Wojtyna, W., Akgöz, H., Akgün, G., Akyürek, O., Batur, M. K., Bayata, S., Deger, N., Emel, O., Gürgün, C., Korkmaz, M. E., Kozan, O., Kumbasar, D., Muderrisoglu, H., Nisanci, Y., Ozin, B., Ozsaruhan, O., Payzin, S., Postaci, N., Sozcuer, H., Tamci, B., Topuzoglu, F., Türkoglu, C., Tutar, E., Ulucam, M., Ulusoy, T., Umman, B., Yalçinkaya, S., Yesil, M., Zoghi, M., Adams, P. C., Ahir, S., Ahsan, A. J., Akhtar, J., Albers, C. J., Al-Khafaji, M. N., Anderson, N., Bailey, R. J., Bain, R. J. I., Basu, A., Beal, A., Boyle, R. M., Brown, N., Campbell, S., Card, D., Cross, S. J., Davies, P., Davis, E. T. L., Dean, J. W., Deaner, A., Devine, M. A., Dhawan, J., Doig, J. C., Dubrey, S., Dunn, P. G., Dwight, J., Ecob, R., Fitzpatrick, H., Fletcher, S., Francis, C. M., Gershlick, A. H., Glennon, P. E., Goodfield, N. E., Grabau, W. J., Gray, M., Gray, K. E., Heath, J., Hendry, W. G., Highland, J., Hogg, K., Irving, J. B., James, M. A., Jennings, K., Joy, M., Kadr, H. H., Kahn, S., Keeling, P. J., Keir, P. M., Kemp, T. M., Kinaird, J., Kinsey, C., Knowles, K., Kooner, J. S., Lahiri, A., Lawson, C., Lewis, R., Macdermott, A. F. N., Mackay, A., Macleod, D. C., Mccance, A. J., Morrison, A., Mortimer, M., Mulvey, D., Murphy, J. J., Murray, S., Muthusamy, R., Myers, A., Nicolson, V. G., Northridge, D., Odemuyiwa, S., Oldroyd, K. G., Oliver, R. M., Pell, A. C. H., Pohl, J. E. F., Price, B., Quereshi, N., Rae, A. P., Reader, S., Reid, D. S., Reynolds, G. W., Robinson, A., Robson, R. H., Rodger, J. C., Rodrigues, E., Rose, E. L., Rowlands, D. B., Rowley, J. M., Rozkovec, A., Shreeve, J., Siklos, P., Smith, R. H., Sneddon, J. F., Somasundram, U., Squire, I., Stephens, J. D., Stephens-Lloyd, A., Strand, J. M., Stuart, J., Sutaria, N., Swan, J., Tait, G. W., Thomas, R. D., Thompson, M. A., Tildesley, G., Travill, C. M., Treadgold, J. A., Trelawney, J. M. S., Turner, D., Vallance, B. D., Wallbridge, D., Weissberg, P. L., White, E., Wicks, M., Wilcox, R. G., Wilkinson, P., Wiltshire, J. E., Wright, A., Andrea, B., Attassi, K., Bahr, R., Banas, J., Baran, K., Belknap, M., Bensman, M., Bertolet, B., Besley, D., Bethala, V., Betzu, R., Bhalla, R., Bhargava, M., Binder, A., Birkhead, R., Bodine, K., Brewer, D., Carey, S., Chengot, M., Coppola, J., Cragg, D., D’Arcy, B., Denny, D. M., Dilorenzo, P., Dixon, E., Doorey, A., Doty, D., Doty, W., Drossner, M., Eisenberg, P., Falco, T., Feldman, R., Freman, I., Frey, M., Garcia, J., Glassman, J., Goldman, S., Gomez, M., Gonzalez, M., Goodfield, P., Gottlieb, S., Grech, D., Hack, T., Haffey, T., Hanson, J., Havranek, E., Hermany, P., Hernandez, H., Herron, R., Hession, W., Hines, J., Hundley, R., Jacobs, W. C., Jerjes-Sanchez, C., Jerome, S., Josephson, R., Kalan, J., Kawalsky, D., Khan, A., Kmetzo, K., Kraemer, M., Lader, E., Landis, J., Lash, J., Leber, R., Leimbach, W., Leiva Garza, J. -L., Maddox, W., Magorien, R., Mahapatra, S., Mantecon, I., Mendelson, R., Miklin, J., Milas, J., Miller, R., Molk, B., Monrad, E. S., Morrison, J., Morse, H., Neustel, M., Nichols, D., Niederman, A., Nygaard, T., O’Connor, R., O’Riordan, W., Obermueller, S., Palmeri, S., Patel, R., Paul, T., Phiambolis, T., Piana, R., Polansky, B., Polinski, W., Ponce, G., Ribeiro, P., Roccario, E., Rogers, C. P., Rogers, W., Rosenblatt, A., Runyon, J. P., Scheel, F., Schmidt, P., Schneider, R., Schwartz, H., Shelhamer, L., Sheridan, F., Shine, W., Shook, T., Siskind, S., Slama, R., Spear, E., Stouffer, G., Strunk, B., Thadani, U., Timmis, G., Trautloff, R., Tse, A., Wohl, B., Zarren, H., Zucker, R., Kuster, F., and Pardie, J. P.

Subjects
Male, Risk, Infusions, medicine.medical_treatment, Myocardial Infarction, Bolus lytic therapy, Acute myocardial infarction, Tissue plasminogen activator, Thrombolytic drug, Double-Blind Method, Fibrinolytic Agents, medicine, Humans, Thrombolytic Therapy, Myocardial infarction, Infusions, Intravenous, Stroke, Aged, business.industry, ST elevation, Lanoteplase, Emergency department, Middle Aged, medicine.disease, Survival Analysis, Regimen, Relative risk, Anesthesia, Tissue Plasminogen Activator, Female, Intracranial Hemorrhages, Cardiology and Cardiovascular Medicine, business, Intravenous, medicine.drug
Abstract

AIMS To compare the efficacy and safety of lanoteplase, a single-bolus thrombolytic drug derived from alteplase tissue plasminogen activator, with the established accelerated alteplase regimen in patients presenting within 6 h of onset of ST elevation acute myocardial infarction. METHODS AND RESULTS 15,078 patients were recruited from 855 hospitals worldwide and randomized in a 2:1 ratio to receive either lanoteplase 120 KU. kg(-1)as a single intravenous bolus, or up to 100 mg accelerated alteplase given over 90 min. The primary end-point was all-cause mortality at 30 days and the hypothesis was that the two treatments would be equivalent. By 30 days, 6.61% of alteplase-treated patients and 6.75% lanoteplase-treated patients had died (relative risk 1.02). Total stroke occurred in 1.53% alteplase- and 1.87% lanoteplase-treated patients (ns); haemorrhagic stroke rates were 0.64% alteplase and 1.12% lanoteplase (P=0.004). The net clinical deficit of 30-day death or non-fatal disabling stroke was 7.0% and 7.2%, respectively. By 6 months, 8.8% of alteplase-treated patients and 8.7% of lanoteplase-treated patients had died. CONCLUSION Single-bolus weight-adjusted lanoteplase is an effective thrombolytic agent, equivalent to alteplase in terms of its impact on survival and with a comparable risk-benefit profile. The single-bolus regimen should shorten symptoms to treatment times and be especially convenient for emergency department or out-of-hospital administration.

Published
2000

25. A 1.3mW CMOS 65nm 4^th order 52dB-DR continuous-time analog filter for DVB-T receivers

Author

DE MATTEIS, M, Cocciolo, G, De Blasi, M, Baschirotto, A, DE MATTEIS, MARCELLO, BASCHIROTTO, ANDREA, DE MATTEIS, M, Cocciolo, G, De Blasi, M, Baschirotto, A, DE MATTEIS, MARCELLO, and BASCHIROTTO, ANDREA

Abstract

In this paper a 8.2MHz-f @-3dB bandwidth Filter-&-Amplifier to be embedded in a DVB-T RX chain is presented. The filter has been integrated in 65nm CMOS node, working with a V DD/V TH ratio (supply/threshold voltage) as low as 2. Operating point issues due to low V DD/V TH ratio has been resolved by a proper bias circuit. Since such bias circuit is part of the filter circuit, its impact on filter performance have been studied and considered in the design. Power consumption is minimized by using a novel algorithm based on Matlab procedure, which guarantees the minimum power consumption for a given transfer function, noise and linearity requirements. The device consumes 1.3mW from a single 1.2V supply voltage, features -10dBm-IIP3 at 32dB pass-band Gain, and 1.6mV rms output integrated noise over the pass-band (300kHz÷8.2MHz). © 2011 IEEE.

Published
2011

26. A CMOS low-power SoC for HID and LED lamps ballast

Author

Costantini, A, Cavalera, G, Pepino, A, DE MATTEIS, M, Cocciolo, G, De Blasi, M, D'Amico, S, Visconti, P, Baschirotto, A, DE MATTEIS, MARCELLO, BASCHIROTTO, ANDREA, Costantini, A, Cavalera, G, Pepino, A, DE MATTEIS, M, Cocciolo, G, De Blasi, M, D'Amico, S, Visconti, P, Baschirotto, A, DE MATTEIS, MARCELLO, and BASCHIROTTO, ANDREA

Abstract

In this work a new concept of hybrid lamps burner is presented. The High Intensity Discharge (HID) lamps and the new generation Light Emitting Diodes (LED) lamps can be driven by the same electronic ballast using this hybrid ASIC in 0.35m CMOS technology. In the state-of-art the electronic ballasts are managed by powerful general-purpose devices (usually FPGA or microcontroller). These devices are not customized for the specific application. Thus they have a larger area occupation and power consumption compared to ASIC solution. The designed ASIC power consumption is 35 mW and the package area is about 6.5 cm2 against 550 mW and 6.5 cm2 for commonly used PIC 18FXX2. © 2011 IEEE.

Published
2011

29. A 255 MHz Programmable Gain Amplifier and Low-Pass Filter for Ultra Low Power Impulse-Radio UWB Receivers.

Author

D'Amico, S., De Blasi, M., De Matteis, M., and Baschirotto, A.

Subjects
*ELECTRONIC amplifiers, *ELECTRONICS, *AMPLIDYNES, *COMPLEMENTARY metal oxide semiconductors, *DIGITAL electronics
Abstract

A 90 nm-CMOS power-optimized analog baseband chain for ultra-low-power impulse-radio ultra-wideband (IR-UWB) receivers is presented. The proposed device merges the functions of a programmable gain amplifier (PGA) and a low-pass filter (LPF). It consists of the cascade of three biquadratic cells made up by opamps in a series-shunt configuration, which features high input impedance, low load effects in the cascade blocks, and better frequency response. The opamp parameters are included in the overall biquad transfer function. This allows getting very low power performance, since the opamp bandwidth is not required to be much larger than the filter cutoff frequency. Moreover, the current consumption is optimized according to the selected gain level (1.3 mA at 0 dB-gain up to 1.9 mA at 40 dB-gain). The PGA features a 0-40 dB programmable gain range with a 5 dB gain-step. The LPF performs a sixth-order 255 MHz low-pass frequency response. For the overall chain the IIP3 is 14 dBm at 0 dB gain, while the input referred noise is 12.5 nV/√Hz at 40 dB gain. [ABSTRACT FROM AUTHOR]

Published
2012
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30. Filelfo e Giustino

Author

Paolo Viti, V.L. Castrignanò, F. De Blasi, M. Maggiore, and Viti, Paolo

Published
2018

32. Structural changes of in vitro matured buffalo and bovine oocytes following cryopreservation

Author

E. Mariotti, Bianca Gasparrini, Serena Di Francesco, Marcello Rubessa, Salvatore Velotto, Marina De Blasi, Gasparrini, Bianca, Di Francesco, S., Rubessa, M., Velotto, Salvatore, Mariottii, E, De Blasi, M., DI FRANCESCO, Serena, Mariotti, E., and DE BLASI, Marina

Subjects
Cryoprotectant, 040301 veterinary sciences, animal diseases, medicine.medical_treatment, Biology, cryopreservation, Cryopreservation, 0403 veterinary science, Andrology, chemistry.chemical_compound, parasitic diseases, Botany, medicine, Vitrification, oocyte, lcsh:SF1-1100, buffalo, In vitro fertilisation, Dimethyl sulfoxide, bovine, 0402 animal and dairy science, 04 agricultural and veterinary sciences, 040201 dairy & animal science, chemistry, Ultrastructure, Oocyte vitrification, Buffalo, Bovine, Toxicity, Spindle organization, Animal Science and Zoology, lcsh:Animal culture, Ethylene glycol
Abstract

The aim of this work was to evaluate chromatin and spindle organization of buffalo and bovine in vitro matured oocytes after vitrification/warming by Cryotop and after their exposure to cryoprotectants (CP). In vitro matured oocytes were vitrified/warmed and exposed to the vitrification/warming solutions containing ethylene glycol (EG), dimethyl sulfoxide (DMSO) and sucrose as CP. Two hours after warming, oocytes were fixed and immunostained for microtubules and nuclei and examined by fluorescence microscopy. Data were analyzed by Chi Square test. A higher percentage of Telophase II stage oocytes was found in the toxicity (26 and 34% in bovine and buffalo) and the vitrification groups (13 and 7% in bovine and buffalo) compared to the control, indicating occurrence of activation. An increased percentage of oocytes with abnormal spindle and chromosome organization was found in oocytes exposed to CP (24 and 13% in bovine; 32 and 30% in buffalo respectively) and in those vitrified (26 and 31% in bovine; 26 and 29% in buffalo respectively) compared to the control (0 in bovine and 2.5 % in buffalo).

Published
2009
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33. A monolithic CMOS automatic biasing system for 40GHz multistage HEMT

Author

Massimo Gervasi, A. Baù, M. Pierri, M. De Matteis, Mario Zannoni, M. De Blasi, Andrea Baschirotto, Stefano D'Amico, A. Passerini, DE BLASI, Marco, M., Pierri, D'Amico, Stefano, M., De Mattei, A., Baschirotto, A., Bau, A., Passerini, M., Gervasi, M., Zannoni, DE BLASI, M, Pierri, M, D'Amico, S, DE MATTEIS, M, Baschirotto, A, Bau', A, Passerini, A, Gervasi, M, and Zannoni, M

Subjects
Engineering, semiconductor device noise, monolithic CMOS automatic biasing system, Hardware_PERFORMANCEANDRELIABILITY, low noise amplifier, HBS, HEMT switch-off operation, CMOS integrated circuit, power 6.2 mW, Electronic circuit, integrated circuit noise, Electrical engineering, high-electron-mobility-transistor, closed-loop stability, CMOS, frequency 40 GHz, Logic gate, off-chip multistage HEMT block, circuit stability, high electron mobility transistor, Transconductance, Capacitance, Microwave filter, High-electron-mobility transistor, Integrated circuit design, HEMT transconductance efficiency, size 0.35 mum, integrated circuit design, MOSFET, gm/IDS ratio, noise-power trade-off, mm-wave, Hardware_INTEGRATEDCIRCUITS, Electronic engineering, HEMT-biasing-system, Operating Point, HEMT, Operating point, business.industry, negative gate-source voltage, current consumption, multistage HEMT, field effect MIMIC, CMOS technology, LNA, Switching circuit, capacitance 100 nF, business
Abstract

The design of an automatic biasing system for High-Electron-Mobility-Transistors is here presented (HEMT-Biasing-System, HBS). The HBS automatically regulates the operating point of an off-chip multistage HEMT block. A proper automatic algorithm is implemented in order to maximize the HEMT transconductance (gm) efficiency (defined as gm/IDS ratio). This is an important feature in several HEMT-based systems, since they are used in LNA stages, where noise/power trade-off is a key aspect. Interfacing CMOS and HEMT technologies features several design issues, like negative gate-source voltage (to be managed by a CMOS circuits for HEMT switch-off operation) and closed-loop stability (due to the presence of very large off-chip capacitance - 100nF). The System here presented manages all these issues with tailored circuit solutions. A prototype has been designed in CMOS 0.35μm technology. It consumes 6.2mW (excluding the current consumption for HEMT driving).

Published
2013

34. A 255 MHz Programmable Gain Amplifier and Low-Pass Filter for Ultra Low Power Impulse-Radio UWB Receivers

Author

M. De Blasi, M. De Matteis, Andrea Baschirotto, Stefano D'Amico, D'Amico, S, De Blasi, M, DE MATTEIS, M, Baschirotto, A, D'Amico, Stefano, M., De Blasi, M., De Mattei, and A., Baschirotto

Subjects
Engineering, ultra-low-power impulse-radio ultra-wideband receiver, Low-pass filter, frequency 255 MHz, law.invention, CMOS power-optimized analog baseband chain, series-shunt configuration, law, size 90 nm, Electronic engineering, ultra low power impulse-radio UWB receiver, ultra wideband communication, Electrical and Electronic Engineering, CMOS integrated circuit, Active filter, low-power electronic, Digital biquad filter, Open-loop gain, low-pass filter, radio receiver, business.industry, Amplifier, programmable gain amplifier, Electrical engineering, biquadratic cell, biquad transfer function, Cutoff frequency, Programmable-gain amplifier, very low power performance, amplifier, Operational amplifier, frequency response, transfer function, business
Abstract

A 90 nm-CMOS power-optimized analog baseband chain for ultra-low-power impulse-radio ultra-wideband (IR-UWB) receivers is presented. The proposed device merges the functions of a programmable gain amplifier (PGA) and a low-pass filter (LPF). It consists of the cascade of three biquadratic cells made up by opamps in a series-shunt configuration, which features high input impedance, low load effects in the cascade blocks, and better frequency response. The opamp parameters are included in the overall biquad transfer function. This allows getting very low power performance, since the opamp bandwidth is not required to be much larger than the filter cutoff frequency. Moreover, the current consumption is optimized according to the selected gain level (1.3 mA at 0 dB-gain up to 1.9 mA at 40 dB-gain). The PGA features a 0-40 dB programmable gain range with a 5 dB gain-step. The LPF performs a sixth-order 255 MHz low-pass frequency response. For the overall chain the IIP3 is 14 dBm at 0 dB gain, while the input referred noise is 12.5 nV/√Hz at 40 dB gain. © 2012 IEEE.

Published
2012

35. A CMOS low-power SoC for HID and LED lamps ballast

Author

Paolo Visconti, M. De Blasi, A. Costantini, G. Cavalera, M. De Matteis, Stefano D'Amico, Andrea Baschirotto, G. Cocciolo, A. Pepino, Costantini, A, Cavalera, G, Pepino, A, DE MATTEIS, M, Cocciolo, G, De Blasi, M, D'Amico, S, Visconti, P, Baschirotto, A, A., Costantini, G., Cavalera, A., Pepino, M., De Mattei, G., Cocciolo, DE BLASI, Marco, D'Amico, Stefano, Visconti, Paolo, and A., Baschirotto

Subjects
Ballast, Engineering, Gas-discharge lamp, business.industry, ASIC, CMOS, Electrical engineering, law.invention, LED lamp, Application-specific integrated circuit, law, Low-power electronics, Hardware_INTEGRATEDCIRCUITS, Electronic engineering, System on a chip, lighting system, SoC, IED, business, HID, Light-emitting diode
Abstract

In this work a new concept of hybrid lamps burner is presented. The High Intensity Discharge (HID) lamps and the new generation Light Emitting Diodes (LED) lamps can be driven by the same electronic ballast using this hybrid ASIC in 0.35m CMOS technology. In the state-of-art the electronic ballasts are managed by powerful general-purpose devices (usually FPGA or microcontroller). These devices are not customized for the specific application. Thus they have a larger area occupation and power consumption compared to ASIC solution. The designed ASIC power consumption is 35 mW and the package area is about 6.5 cm2 against 550 mW and 6.5 cm2 for commonly used PIC 18FXX2. © 2011 IEEE.

Published
2011

36. A 16 bit 20 kHz bandwidth discrete-time RD modulator with VCO-based quantizer

Author

P. Delizia, M. De Blasi, Stefano D'Amico, Andrea Baschirotto, DE BLASI, Marco, P., Delizia, D'Amico, Stefano, A., Baschirotto, De Blasi, M, Delizia, P, D’Amico, S, and Baschirotto, A

Subjects
Engineering, business.industry, Amplifier, Electrical engineering, Delta-sigma modulation, Surfaces, Coatings and Films, 16-bit, Voltage-controlled oscillator, Discrete time and continuous time, Hardware and Architecture, Robustness (computer science), Integrator, Signal Processing, Technology scaling, Electronic engineering, business, Sigma Delta
Abstract

In this paper the design of a 3rd-order 16 bit 20 kHz-bandwidth discrete-time σδ modulator with voltage- controlled oscillator (VCO)-based quantizer is presented. This design is motivated by the trends towards die size and power consumption reduction together with performance robustness. In this direction, the flash converter embedded in a multi-bit σδM is here replaced by a VCO and digital counter, resulting in a compact fully-digital quantizer implementation. This solution would greatly exploit the technology scaling. Moreover in the proposed feed-forward architecture all feed-forward paths are summed within the last integrator of the σδ loop filter, thereby eliminating the need for an analog summation amplifier at the quantizer input The presented 3rd-order σδM features 110 dB-SNR, 104 dB-SNDR (i.e. 16 bit-ENOB). © Springer Science+Business Media, LLC 2011.

Published
2011

37. A Multicomputer Building Block for Prolog Architectures

Author

DE BLASI, Mario, ALOISIO, Giovanni, BOCHICCHIO, Mario Alessandro, A. GENTILE, F. GRECO, I. PAGLIARA, DE BLASI, M., Aloisio, Giovanni, Bochicchio, Mario Alessandro, Gentile, A., Greco, F., Pagliara, I., DE BLASI, Mario, A., Gentile, F., Greco, and I., Pagliara

Abstract

Pubblicato su "EC Newsletter" (rivista assente in questo archivio) e Ristampato per "Med-Campus Distance Learning Computer Science School, Lecce, Italy, 1993"

Published
1993

38. A 600mV baseband analog filter for UMTS receivers

Author

Vito Giannini, M. De Matteis, Andrea Baschirotto, M. De Blasi, Stefano D'Amico, D'Amico, Stefano, DE BLASI, Marco, DE MATTEIS, Marcello, Giannini, Vito, Baschirotto, Andrea, D'Amico, S, De Blasi, M, DE MATTEIS, M, Giannini, V, and Baschirotto, A

Subjects
Engineering, Voltage-controlled filter, Low-pass filter, wide swing performance, 600 mV, Band-stop filter, UMTS receiver, Hardware_INTEGRATEDCIRCUITS, Electronic engineering, opamp input, CMOS integrated circuit, Active filter, common mode level, fourth order low-pass analog filter, operational amplifier, active filter, low-pass filter, radio receiver, business.industry, Electrical engineering, Butterworth filter, CMOS technology, filter output, Filter design, filter input, 3G mobile communication, Filter (video), RC circuit, baseband analog filter, analog active-RC filter, business, 0.13 micron, Digital filter
Abstract

In this paper an approach for the design of low-voltage analog Active-RC filers is presented. This technique is based on the use of different common mode levels at the opamp inputs and the filter inputs and outputs. A design example of a 600mV supply voltage 4th order low-pass analog filter for UMTS receivers is reported. The filter is designed in a 0.13μm CMOS technology with a 600mV supply voltage. The filter features a wide swing performance (THD=40dB@800mVpp,differential output signal amplitude), and high dynamic range (47 dB). © 2006 IEEE.

39. Optical spectral transmission to assess glucocorticoid therapy response in patients with arthritis: a longitudinal follow-up comparison with joint ultrasound.

Author

Triantafyllias K, Marinoska T, Heller C, de Blasi M, Muthuraman M, and Schwarting A

Subjects
Humans, Bayes Theorem, Finger Joint diagnostic imaging, Follow-Up Studies, Glucocorticoids therapeutic use, Severity of Illness Index, Ultrasonography, Ultrasonography, Doppler, Wrist Joint diagnostic imaging, Arthritis, Rheumatoid drug therapy, Synovitis diagnosis
Abstract

Background: Optical spectral transmission (OST) is a modern diagnostic modality, able to assess the blood-specific absorption of light transmitted through a tissue, promising quantification of inflammation in the finger and wrist joints of patients with arthritis. To date, there are no adequate data regarding the diagnostic value of OST in the evaluation of inflammatory activity changes, during arthritis follow-up. Objectives of this study were therefore to examine the performance of OST in assessing response to anti-inflammatory therapy in patients with active arthritis and to explore OST associations with clinical, laboratory, and ultrasonographic (US) activity markers., Methods: 1173 joints of 54 patients with arthritides of the wrist and finger joints were examined by OST before and after oral administration of glucocorticoids (GC), during a disease flare. For the same time-points patients underwent clinical, laboratory, and joint US [grayscale (GSUS), power-Doppler (PDUS)] examinations. The distribution of ΔOST-values between the two time-points was compared with the respective distributions of ΔPDUS and ΔGSUS by Bayesian statistical analyses. Moreover, the diagnostic performance of OST compared to a control group (2508 joints of 114 subjects) was examined by receiver operating characteristics and associations of OST values with clinical, laboratory, and arthrosonographic parameters were evaluated by correlation analyses., Results: OST and US performed similarly in the assessment of inflammatory changes caused by GC (same value-change tendency in 83.2% of the cases). Bayesian statistics revealed no significant differences between ΔOST and ΔPDUS for all 3 examined joint categories (accuracy: metacarpophalangeal (MCP): 68.1%; proximal interphalangeal (PIP): 60.4%; wrists: 50.4%) and between ΔOST and ΔGSUS for MCP and PIP joints (accuracy: 51.1% and 78.7%, respectively). OST diagnostic performance (patients vs. controls) was excellent in both time-points [area under the curve (AUC) before GC=0.883(95%CI=0.83-0.94) and after GC=0.811(95%CI=0.74-0.881); p<0.001]. Furthermore, OST correlated significantly with all examined sonographic activity scores (all; p<0.001) and with swollen joint counts (p<0.01)., Conclusions: OST was able to assess response to therapy in a similar way to joint US and correlated significantly with arthritis activity markers. Therefore, OST has proved to be a valuable tool to assist disease activity monitoring in the examined cohort., Trial Registration: German Registry of Clinical Trials, DRKS00016752., (© 2023. The Author(s).)

Published
2023
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40. Pectin as Rheology Modifier of a Gelatin-Based Biomaterial Ink.

Author

Lapomarda A, Pulidori E, Cerqueni G, Chiesa I, De Blasi M, Geven MA, Montemurro F, Duce C, Mattioli-Belmonte M, Tiné MR, Vozzi G, and De Maria C

Abstract

Gelatin is a natural biopolymer extensively used for tissue engineering applications due to its similarities to the native extracellular matrix. However, the rheological properties of gelatin formulations are not ideal for extrusion-based bioprinting. In this work, we present an approach to improve gelatin bioprinting performances by using pectin as a rheology modifier of gelatin and (3-glycidyloxypropyl)trimethoxysilane (GPTMS) as a gelatin-pectin crosslinking agent. The preparation of gelatin-pectin formulations is initially optimized to obtain homogenous gelatin-pectin gels. Since the use of GPTMS requires a drying step to induce the completion of the crosslinking reaction, microporous gelatin-pectin-GPTMS sponges are produced through freeze-drying, and the intrinsic properties of gelatin-pectin-GPTMS networks (e.g., porosity, pore size, degree of swelling, compressive modulus, and cell adhesion) are investigated. Subsequently, rheological investigations together with bioprinting assessments demonstrate the key role of pectin in increasing the viscosity and the yield stress of low viscous gelatin solutions. Water stable, three-dimensional, and self-supporting gelatin-pectin-GPTMS scaffolds with interconnected micro- and macroporosity are successfully obtained by combining extrusion-based bioprinting and freeze-drying. The proposed biofabrication approach does not require any additional temperature controller to further modulate the rheological properties of gelatin solutions and it could furthermore be extended to improve the bioprintability of other biopolymers.

Published
2021
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41. Possible misclassification of cardiovascular risk by SCORE in antisynthetase syndrome: results of the pilot multicenter study RI.CAR.D.A.

Author

Triantafyllias K, Cavagna L, Klonowski A, Drott U, Fiehn C, Wendel S, Bergner R, de Blasi M, Voll RE, Baulmann J, Konstantinides S, Galle PR, and Schwarting A

Subjects
Adult, Carotid Arteries diagnostic imaging, Carotid Arteries pathology, Carotid Artery Diseases diagnosis, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases pathology, Carotid Intima-Media Thickness, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Myositis pathology, Pilot Projects, Prospective Studies, Vascular Stiffness, Heart Disease Risk Factors, Myositis diagnosis
Abstract

Objectives: To test the ability of an established traditional cardiovascular (CV) risk prediction score [Systematic COronary Risk Evaluation (SCORE)] and its EULAR modified version (mSCORE) to identify antisynthetase syndrome (ASyS) patients at high CV risk and to examine for the first time associations of CV and cerebrovascular surrogate markers with clinical and immunological ASyS parameters., Methods: SCORE/mSCORE and the gold standard marker of aortic stiffness [carotid-femoral pulse wave velocity (cfPWV)] were examined in ASyS patients and healthy controls. Moreover, sonography of the common- (CCA) and internal- (ICA) carotid arteries was performed in subsets of both groups, evaluating carotid intima-media thickness (cIMT), plaques and Doppler sonographic cerebrovascular surrogates [resistance (RI) and pulsatility (PI) indices]., Results: We recruited 66 ASyS patients and 88 controls. According to mSCORE, 10% of the patients had high CV risk. However, cfPWV and carotid sonography revealed an increased CV risk in 21.2% and subclinical carotid atherosclerosis (SCA) in 85.7% of the patients, respectively. cfPWV and cIMT were higher in patients compared with controls (Padj=0.021 and Padj=0.003, respectively). In the ASyS group, cfPWV and cIMT correlated significantly with age (r = 0.679; P<0.001 and r = 0.664; P<0.001, respectively). Moreover, cfPWV correlated with BMI (Padj=0.001) and diabetes (Padj=0.043). CCA-RI and CCA-PI showed significant associations with creatine phosphokinase (r = 0.629; P=0.012 and r = 0.574; P=0.032, respectively) and ICA-RI and ICA-PI were higher in patients with lung involvement (both; P=0.039)., Conclusion: ASyS patients had higher aortic stiffness and SCA compared with controls, even after adjustment for confounders. SCORE/mSCORE performed poorly in identifying high-risk patients compared with cfPWV and carotid sonography. Thus, cfPWV and carotid sonography may improve CV and cerebrovascular screening in ASyS., (© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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42. High cardiovascular risk in mixed connective tissue disease: evaluation of macrovascular involvement and its predictors by aortic pulse wave velocity.

Author

Triantafyllias K, de Blasi M, Lütgendorf F, Cavagna L, Stortz M, Weinmann-Menke J, Konstantinides S, Galle PR, and Schwarting A

Subjects
Aorta physiopathology, Blood Pressure, Humans, Pulse Wave Analysis, Risk Factors, Cardiovascular Diseases etiology, Mixed Connective Tissue Disease complications, Vascular Stiffness
Abstract

Objectives: Macrovascular involvement and cardiovascular (CV) risk has not been sufficiently studied in mixed connective tissue disease (MCTD). In particular, the gold standard assessment method of aortic stiffness carotid-femoral pulse wave velocity (cfPWV) has never been evaluated in patients with this disease. The aims of the present study were therefore to examine cfPWV in MCTD and to evaluate its associations with MCTD-associated markers and traditional CV risk factors., Methods: Measurements of cfPWV were performed in 43 MCTD patients and 107 healthy controls. The difference between cfPWV in the two groups was statistically examined and subsequently controlled for the effect of possible confounding factors. The association of cfPWV with MCTD-associated organ involvement, routine laboratory parameters and immunoserological markers was also evaluated. Finally, the relationship of cfPWV with medications and traditional CV risk factors was examined., Results: Adjusted statistical analyses for confounding factors showed significantly higher cfPWV values in MCTD patients in comparison to controls (padj<0.001). cfPWV correlated in both the patients and the control group significantly with age (rho=0.69, p<0.001 and rho=0.67, p<0.001 respectively) and diastolic arterial pressure (padj=0.024 and padj=0.032 respectively). Moreover, cfPWV correlated in the control group with systolic and mean arterial pressure (padj<0.001 and p=0.002 respectively). Finally, higher cfPWV values could be documented in the subset of MCTD patients without lung involvement (padj=0.007)., Conclusions: Patients with MCTD have significantly higher aortic stiffness and thus CV risk in comparison to controls. Except for the disease itself, age and blood pressure were the main predictors of cfPWV.

Published
2019

44. The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis.

Author

Triantafyllias K, De Blasi M, Hoffmann I, Thomaidis T, Drees P, and Schwarting A

Abstract

Background: Patients with rheumatoid arthritis (RA) are at a higher cardiovascular (CV) risk in comparison to the general population. CV risk associates closely with aortic stiffness. Aim of this exploration was therefore to evaluate aortic stiffness in patients with RA and to examine its association with various RA associated parameters as well as with traditional CV risk factors., Methods: Measurements of carotid-femoral pulse wave velocity (cfPWV) were analyzed retrospectively in 38 RA patients and 25 controls. We investigated the statistical difference between cfPWV values in the two groups. Furthermore, we analyzed the associations of cfPWV with laboratory and clinical RA parameters including Disease Activity Score 28 and its components, rheumatoid factor, cyclic citrullinated peptide antibodies, antinuclear antibodies and RA duration. Finally, we explored the relationship of cfPWV with traditional CV risk factors in the RA group., Results: cfPWV was not significantly higher in RA patients in comparison to controls in an adjusted statistical model for confounding factors [-0.587 95 % CI (-1.38 to 0.201), p = 0.144]. Among RA patients there was a statistically significant correlation of cfPWV with age (rho = 0.544, p = 0.001) and the count of tender joints [0.051 95 % CI (0.008-0.207), p = 0.034]. Finally, C-reactive protein associated only marginally with cfPWV [0.105 95 % CI (-0.410 to 0.003), p = 0.053]., Conclusions: In RA patients the number of tender, rather than swollen joints correlates with stiffness of the aorta, as measured through cfPWV. Therefore, RA associated joint pain might play a role in the development of aortic stiffness and thus increase CV risk.

Published
2016
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45. [Efficacy of team work in health promotion and secondary prevention in patients admitted for cardiovascular rehabilitation].

Author

Giobergia E, Mento C, Pasero E, Chizzolini G, Vallauri P, De Blasi M, Peano M, Salvatico L, and Feola M

Subjects
Adult, Aged, Aged, 80 and over, Coronary Disease rehabilitation, Female, Health Knowledge, Attitudes, Practice, Humans, Italy, Life Style, Male, Middle Aged, Patient Education as Topic methods, Retrospective Studies, Surveys and Questionnaires, Coronary Disease prevention & control, Health Promotion methods, Inpatients, Patient Care Team, Secondary Prevention
Abstract

Unlabelled: The object of the study was to evaluate the immediate efficacy of periodical educational meetings organized in Cardiovascular Rehabilitation Department aimed to improve knowledge about cardiovascular pathology, risk factors and correct life style., Methods: From October 2008 a multiprofessional group organized educational meetings for patients and their relatives, using two questionnaires to explore patients' level of knowledge, before and after the meeting., Results: 124 patients (90 males) answered the questionnaire 1, while questionnaire 2 was completed by 93 subjects (70 males). From the answers to questionnaire 1, a significant improvement of knowledge about coronary anatomy and cardiovascular therapy emerged. Indeed, 99% of patients vs 81% before the meeting (p=0.001) understood the coronary artery function, 69% vs 44% (p=0,0001) of participants was familiar with coronary angioplasty, 81% vs. 64% (p=0,003) demonstrated to understand the coronary artery bypass and finally 85% vs. 52% (p=0,0001) were able to distinguish mechanical from biological prosthesis. From answers to questionnaire 2, a trend in favour to an improvement of knowledge regarding coronary risk factors and correct life style emerged. Younger patients (<70 ys) had a higher baseline level knowledge (p=0,003 and p=0.001 group 1 and 2, respectively) compared to older subjects, but in the latter a trend in favour of enhanced knowledge (p=0.06) after the educational meetings emerged., Conclusions: Educational meetings are significantly correlated with an improvement of patients' knowledge regarding cardiovascular pathology and treatments independently from patients' age.

Published
2010
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46. The use of magnetic resonance in myocardial ischaemia.

Author

De Filippo M, Sudberry JJ, Borgia D, Rovani C, Chernyschova N, Salati F, Cagnoni G, De Blasi M, Beghi C, and Zompatori M

Subjects
Coronary Angiography, Coronary Circulation, Humans, Kinetics, Myocardial Contraction, Myocardial Infarction diagnostic imaging, Myocardial Infarction pathology, Myocardial Ischemia diagnostic imaging, Myocardial Ischemia physiopathology, Myocardium pathology, Organ Size, Reproducibility of Results, Magnetic Resonance Imaging methods, Myocardial Ischemia pathology
Abstract

Despite the efforts that have been made at an international level to identify and control cardiovascular risk factors, cardiopathies and, in particular, coronary artery disease (CAD), remain the principal cause of death in Europe and the United States. These data confirm the importance and necessity of noninvasive, reliable diagnostic imaging of early CAD. Coronary angiography is still the hinge, around which all instrumental and laboratory investigations turn, for cardiac ischaemia today. Indeed, it still holds the role of "gold standard" for the study of the coronary arterial lumina, particularly the smaller vessels due to their complex spatial geometry and because of cardiac motion. At present, with the exception of the study of the coronary arterial lumen, MR is a non-invasive examination, already capable of supplying precise global and regional function, the evaluation of the intra-cardiac flow, myocardial perfusion and the overall viability of the heart.

Published
2005

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