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9 results on '"Dasseni, Nicolò"'

2. Thromboembolism in Heart Failure Patients in Sinus Rhythm: Epidemiology, Pathophysiology, Clinical Trials, and Future Direction

Author

Lin, Andrew Y, Dinatolo, Elisabetta, Metra, Marco, Sbolli, Marco, Dasseni, Nicolò, Butler, Javed, and Greenberg, Barry H

Subjects
thromboembolic events, Heart Failure, sinus rhythm, Thromboembolism, anticoagulation, heart failure, stroke, Anticoagulants, Factor Xa Inhibitors, Humans, Warfarin, Atrial Fibrillation
Abstract

Despite advances in medical and device therapy, patients with heart failure remain at high risk for morbidity and mortality. Experimental and clinical studies have shown an association between heart failure and a hypercoagulable state, and that patients with heart failure experience an increased incidence of stroke and other thromboembolic events, regardless of whether they are in atrial fibrillation. Although oral anticoagulation is recommended when atrial fibrillation is present, the benefits of this therapy in patients with heart failure in sinus rhythm are uncertain. Older randomized controlled trials comparing warfarin with antiplatelet therapy were, for the most part, underpowered and failed to show convincing benefits of warfarin therapy in this population. Several recent studies that assessed the effects of low-dose direct-acting oral anticoagulant therapy in patients with coronary artery disease in sinus rhythm either included or specifically targeted patients with heart failure. Post hoc analysis of their results showed that this treatment strategy was associated with improved outcomes in patients with acute coronary syndrome or stable coronary artery disease and also a significant reduction in thromboembolic events, including ischemic stroke. This review presents the rationale for anticoagulant therapy in patients with heart failure in sinus rhythm, discusses gaps in our knowledge base, offers suggestions for when anticoagulation might be considered, and identifies potential directions for future research.

Published
2020

3. Secondary prevention advices after cardiovascular index event: From drug prescription to risk factors control in real world practice

Author

Faggiano, Pompilio, primary, Fattirolli, Francesco, additional, Frisinghelli, Anna, additional, Piccioli, Lucrezia, additional, Dasseni, Nicolò, additional, Silverii, Maria Vittoria, additional, Albricci, Laura, additional, D'Ambrosio, Giuseppe, additional, Garrì, Rosaria, additional, Esposito, Luigi, additional, and Giallauria, Francesco, additional

Published
2019
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7. Cardiac Prevention and Rehabilitation “3.0”: From acute to chronic phase. Position Paper of the ltalian Association for Cardiovascular Prevention and Rehabilitation (GICR-IACPR)

Author

Pedretti, Roberto F.E., primary, Fattirolli, Francesco, additional, Griffo, Raffaele, additional, Ambrosetti, Marco, additional, Angelino, Elisabetta, additional, Brazzo, Silvia, additional, Corrà, Ugo, additional, Dasseni, Nicolò, additional, Faggiano, Pompilio, additional, Favretto, Giuseppe, additional, Febo, Oreste, additional, Ferrari, Marina, additional, Giallauria, Francesco, additional, Greco, Cesare, additional, Iannucci, Manuela, additional, La Rovere, Maria Teresa, additional, Mallardo, Mario, additional, Mazza, Antonio, additional, Piepoli, Massimo, additional, Riccio, Carmine, additional, Scalvini, Simonetta, additional, Tavazzi, Luigi, additional, Temporelli, Pier Luigi, additional, and Mureddu, Gian Francesco, additional

Published
2018
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8. Iron deficiency from the standpoint of cardiac rehabilitation: novel therapeutic opportunities.

Author

Malfatto, Gabriella, Frisinghelli, Anna, Ambrosetti, Marco, La Rovere, Maria Teresa, Motta, Irene, Passaretti, Bruno, Pavesi, Marco, Tramarin, Roberto, Dasseni, Nicolò, and Faggiano, Pompilio

Subjects
IRON deficiency, CARDIAC rehabilitation, IRON deficiency anemia, CORONARY disease, CARDIAC surgery
Abstract

Anemia is one of the most frequent comorbidities found in patients with coronary artery disease and chronic heart failure (CHF) who are being followed in cardiac rehabilitation facilities. The more frequent type of anemia is that caused by iron deficiency (IDA, iron-deficiency anemia): this review summarizes the state of the art of this topic. First of all, the mechanisms of IDA will be analyzed. Subsequently, a description of the main conditions where IDA can unfavorably affect the clinical course, and of its more frequent complications, will be presented (percutaneous interventions, heart surgery, CHF). Special attention will be paid in the description of anemia in the setting of CHF. To this regard, in recent years a relevant amount of research has been carried out, to determine whether treating anemia (either by directly stimulating erythropoiesis or by correcting iron deficiency by oral or intravenous route) is of any clinical and prognostic relevance in patients with CHF. The results of this research will therefore be summarized and critically discussed. Finally, we will outline the promising role of cardiac rehabilitation facilities and of its network of experts in the diagnosis, prognostic stratification and treatment of anemia and iron deficiency. [ABSTRACT FROM AUTHOR]

Published
2019
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