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1,355 results on '"Döhner, Konstanze"'

2. Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients

Author

Halik, Adriane, Tilgner, Marlon, Silva, Patricia, Estrada, Natalia, Altwasser, Robert, Jahn, Ekaterina, Heuser, Michael, Hou, Hsin-An, Pratcorona, Marta, Hills, Robert K., Metzeler, Klaus H., Fenwarth, Laurene, Dolnik, Anna, Terre, Christine, Kopp, Klara, Blau, Olga, Szyska, Martin, Christen, Friederike, Krönke, Jan, Vasseur, Loïc, Löwenberg, Bob, Esteve, Jordi, Valk, Peter J. M., Duchmann, Matthieu, Chou, Wen-Chien, Linch, David C., Döhner, Hartmut, Gale, Rosemary E., Döhner, Konstanze, Bullinger, Lars, Yoshida, Kenichi, and Damm, Frederik

Published
2024
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4. Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease

Author

Heitmann, Jonas S., Schlenk, Richard F., Dörfel, Daniela, Kayser, Sabine, Döhner, Konstanze, Heuser, Michael, Thol, Felicitas, Kapp-Schwoerer, Silke, Labrenz, Jannik, Edelmann, Dominic, Märklin, Melanie, Vogel, Wichard, Bethge, Wolfgang, Walz, Juliane S., Große-Hovest, Ludger, Steiner, Martin, Jung, Gundram, and Salih, Helmut R.

Published
2023
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5. Measurable residual disease monitoring in AML with FLT3-ITD treated with intensive chemotherapy plus midostaurin

Author

Rücker, Frank G., Bullinger, Lars, Cocciardi, Sibylle, Skambraks, Sabrina, Luck, Tamara J., Weber, Daniela, Krzykalla, Julia, Pozek, Ema, Schneider, Isabelle, Corbacioglu, Andrea, Gaidzik, Verena I., Meid, Annika, Aicher, Sophia, Stegelmann, Frank, Schrade, Anika, Theis, Frauke, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Götze, Katharina S., Kühn, Michael W. M., Lübbert, Michael, Schlenk, Richard F., Benner, Axel, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, and Döhner, Konstanze

Published
2024
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6. AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology

Author

Klever, Marius-Konstantin, Sträng, Eric, Hetzel, Sara, Jungnitsch, Julius, Dolnik, Anna, Schöpflin, Robert, Schrezenmeier, Jens-Florian, Schick, Felix, Blau, Olga, Westermann, Jörg, Rücker, Frank G., Xia, Zuyao, Döhner, Konstanze, Schrezenmeier, Hubert, Spielmann, Malte, Meissner, Alexander, Melo, Uirá Souto, Mundlos, Stefan, and Bullinger, Lars

Published
2023
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7. Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study

Author

Fenaux, Pierre, Gobbi, Marco, Kropf, Patricia L., Issa, Jean-Pierre J., Roboz, Gail J., Mayer, Jiri, Krauter, Jürgen, Robak, Tadeusz, Kantarjian, Hagop, Novak, Jan, Jedrzejczak, Wieslaw. W., Thomas, Xavier, Ojeda-Uribe, Mario, Miyazaki, Yasushi, Min, Yoo Hong, Yeh, Su-Peng, Brandwein, Joseph, Gercheva-Kyuchukova, Liana, Demeter, Judit, Griffiths, Elizabeth, Yee, Karen, Döhner, Konstanze, Hao, Yong, Keer, Harold, Azab, Mohammad, and Döhner, Hartmut

Published
2023
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9. Netboost: Boosting-supported network analysis improves high-dimensional omics prediction in acute myeloid leukemia and Huntington's disease

Author

Schlosser, Pascal, Knaus, Jochen, Schmutz, Maximilian, Döhner, Konstanze, Plass, Christoph, Bullinger, Lars, Claus, Rainer, Binder, Harald, Lübbert, Michael, and Schumacher, Martin

Subjects
Quantitative Biology - Genomics, Statistics - Applications, Statistics - Methodology
Abstract

Background: State-of-the art selection methods fail to identify weak but cumulative effects of features found in many high-dimensional omics datasets. Nevertheless, these features play an important role in certain diseases. Results: We present Netboost, a three-step dimension reduction technique. First, a boosting-based filter is combined with the topological overlap measure to identify the essential edges of the network. Second, sparse hierarchical clustering is applied on the selected edges to identify modules and finally module information is aggregated by the first principal components. The primary analysis is than carried out on these summary measures instead of the original data. We demonstrate the application of the newly developed Netboost in combination with CoxBoost for survival prediction of DNA methylation and gene expression data from 180 acute myeloid leukemia (AML) patients and show, based on cross-validated prediction error curve estimates, its prediction superiority over variable selection on the full dataset as well as over an alternative clustering approach. The identified signature related to chromatin modifying enzymes was replicated in an independent dataset of AML patients in the phase II AMLSG 12-09 study. In a second application we combine Netboost with Random Forest classification and improve the disease classification error in RNA-sequencing data of Huntington's disease mice. Conclusion: Netboost improves definition of predictive variables for survival analysis and classification. It is a freely available Bioconductor R package for dimension reduction and hypothesis generation in high-dimensional omics applications.

Published
2019
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10. Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications

Author

Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Wulf, Gerald, Salih, Helmut, Lübbert, Michael, Kühn, Michael W.M., Schroeder, Thomas, Salwender, Hans, Götze, Katharina, Westermann, Jörg, Fransecky, Lars, Mayer, Karin, Hertenstein, Bernd, Ringhoffer, Mark, Tischler, Hans-Joachim, Machherndl-Spandl, Sigrid, Schrade, Anika, Paschka, Peter, Gaidzik, Verena I., Theis, Frauke, Thol, Felicitas, Heuser, Michael, Schlenk, Richard F., Bullinger, Lars, Saadati, Maral, Benner, Axel, Larson, Richard, Stone, Richard, Döhner, Konstanze, and Ganser, Arnold

Published
2022
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12. Unified classification and risk-stratification in Acute Myeloid Leukemia

Author

Tazi, Yanis, Arango-Ossa, Juan E., Zhou, Yangyu, Bernard, Elsa, Thomas, Ian, Gilkes, Amanda, Freeman, Sylvie, Pradat, Yoann, Johnson, Sean J., Hills, Robert, Dillon, Richard, Levine, Max F., Leongamornlert, Daniel, Butler, Adam, Ganser, Arnold, Bullinger, Lars, Döhner, Konstanze, Ottmann, Oliver, Adams, Richard, Döhner, Hartmut, Campbell, Peter J., Burnett, Alan K., Dennis, Michael, Russell, Nigel H., Devlin, Sean M., Huntly, Brian J. P., and Papaemmanuil, Elli

Published
2022
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13. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Author

Schnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A., Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei, Heidenreich, Olaf, Mann, Matthias, Lane, Steven W., Bullinger, Lars, Ori, Alessandro, von Eyss, Björn, Bonifer, Constanze, and Heidel, Florian H.

Published
2022
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14. Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations

Author

Heuser, Michael, Heida, Bennet, Büttner, Konstantin, Wienecke, Clara Philine, Teich, Katrin, Funke, Carolin, Brandes, Maximilian, Klement, Piroska, Liebich, Alessandro, Wichmann, Martin, Neziri, Blerina, Chaturvedi, Anuhar, Kloos, Arnold, Mintzas, Konstantinos, Gaidzik, Verena I., Paschka, Peter, Bullinger, Lars, Fiedler, Walter, Heim, Albert, Puppe, Wolfram, Krauter, Jürgen, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Stadler, Michael, Hambach, Lothar, Gabdoulline, Razif, and Thol, Felicitas

Published
2021
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16. Genomic characterization of AML with aberrations of chromosome 7:a multinational cohort of 519 patients

Author

Halik, Adriane, Tilgner, Marlon, Silva, Patricia, Estrada, Natalia, Altwasser, Robert, Jahn, Ekaterina, Heuser, Michael, Hou, Hsin An, Pratcorona, Marta, Hills, Robert K., Metzeler, Klaus H., Fenwarth, Laurene, Dolnik, Anna, Terre, Christine, Kopp, Klara, Blau, Olga, Szyska, Martin, Christen, Friederike, Krönke, Jan, Vasseur, Loïc, Löwenberg, Bob, Esteve, Jordi, Valk, Peter J.M., Duchmann, Matthieu, Chou, Wen Chien, Linch, David C., Döhner, Hartmut, Gale, Rosemary E., Döhner, Konstanze, Bullinger, Lars, Yoshida, Kenichi, Damm, Frederik, Halik, Adriane, Tilgner, Marlon, Silva, Patricia, Estrada, Natalia, Altwasser, Robert, Jahn, Ekaterina, Heuser, Michael, Hou, Hsin An, Pratcorona, Marta, Hills, Robert K., Metzeler, Klaus H., Fenwarth, Laurene, Dolnik, Anna, Terre, Christine, Kopp, Klara, Blau, Olga, Szyska, Martin, Christen, Friederike, Krönke, Jan, Vasseur, Loïc, Löwenberg, Bob, Esteve, Jordi, Valk, Peter J.M., Duchmann, Matthieu, Chou, Wen Chien, Linch, David C., Döhner, Hartmut, Gale, Rosemary E., Döhner, Konstanze, Bullinger, Lars, Yoshida, Kenichi, and Damm, Frederik

Abstract

Background: Deletions and partial losses of chromosome 7 (chr7) are frequent in acute myeloid leukemia (AML) and are linked to dismal outcome. However, the genomic landscape and prognostic impact of concomitant genetic aberrations remain incompletely understood. Methods: To discover genetic lesions in adult AML patients with aberrations of chromosome 7 [abn(7)], 60 paired diagnostic/remission samples were investigated by whole-exome sequencing in the exploration cohort. Subsequently, a gene panel including 66 genes and a SNP backbone for copy-number variation detection was designed and applied to the remaining samples of the validation cohort. In total, 519 patients were investigated, of which 415 received intensive induction treatment, typically containing a combination of cytarabine and anthracyclines. Results: In the exploration cohort, the most frequently mutated gene was TP53 (33%), followed by epigenetic regulators (DNMT3A, KMT2C, IDH2) and signaling genes (NRAS, PTPN11). Thirty percent of 519 patients harbored ≥ 1 mutation in genes located in commonly deleted regions of chr7—most frequently affecting KMT2C (16%) and EZH2 (10%). KMT2C mutations were often subclonal and enriched in patients with del(7q), de novo or core-binding factor AML (45%). Cancer cell fraction analysis and reconstruction of mutation acquisition identified TP53 mutations as mainly disease-initiating events, while del(7q) or −7 appeared as subclonal events in one-third of cases. Multivariable analysis identified five genetic lesions with significant prognostic impact in intensively treated AML patients with abn(7). Mutations in TP53 and PTPN11 (11%) showed the strongest association with worse overall survival (OS, TP53: hazard ratio [HR], 2.53 [95% CI 1.66–3.86]; P < 0.001; PTPN11: HR, 2.24 [95% CI 1.56–3.22]; P < 0.001) and relapse-free survival (RFS, TP53: HR, 2.3 [95% CI 1.25–4.26]; P = 0.008; PTPN11: HR, 2.32 [95% CI 1.33–

Published
2024

18. Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial

Author

Kapp-Schwoerer, Silke, Weber, Daniela, Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Krönke, Jan, Theis, Frauke, Rücker, Frank G., Teleanu, Maria-Veronica, Panina, Ekaterina, Jahn, Nikolaus, Herzig, Julia, Kubanek, Lena, Schrade, Anika, Göhring, Gudrun, Fiedler, Walter, Kindler, Thomas, Schroeder, Thomas, Mayer, Karin T., Lübbert, Michael, Wattad, Mohammed, Götze, Katharina S., Horst, Heinz A., Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Bentz, Martin, Krauter, Jürgen, Bullinger, Lars, Krzykalla, Julia, Benner, Axel, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, and Döhner, Konstanze

Published
2020
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19. Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication

Author

Jahn, Nikolaus, Terzer, Tobias, Sträng, Eric, Dolnik, Anna, Cocciardi, Sibylle, Panina, Ekaterina, Corbacioglu, Andrea, Herzig, Julia, Weber, Daniela, Schrade, Anika, Götze, Katharina, Schröder, Thomas, Lübbert, Michael, Wellnitz, Dominique, Koller, Elisabeth, Schlenk, Richard F., Gaidzik, Verena I., Paschka, Peter, Rücker, Frank G., Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Benner, Axel, Döhner, Hartmut, Bullinger, Lars, and Döhner, Konstanze

Published
2020
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20. Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial

Author

Voso, Maria Teresa, Larson, Richard A., Jones, Dan, Marcucci, Guido, Prior, Thomas, Krauter, Jürgen, Heuser, Michael, Lavorgna, Serena, Nomdedeu, Josep, Geyer, Susan M., Walker, Alison, Wei, Andrew H., Sierra, Jorge, Sanz, Miguel A., Brandwein, Joseph M., de Witte, Theo M., Jansen, Joop H., Niederwieser, Dietger, Appelbaum, Frederick R., Medeiros, Bruno C., Tallman, Martin S., Schlenk, Richard F., Ganser, Arnold, Amadori, Sergio, Cheng, Yuan, Chen, YinMiao, Pallaud, Celine, Du, Ling, Piciocchi, Alfonso, Ehninger, Gerhard, Byrd, John, Thiede, Christian, Döhner, Konstanze, Stone, Richard M., Döhner, Hartmut, Bloomfield, Clara D., and Lo-Coco, Francesco

Published
2020
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21. Real-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia

Author

Rautenberg, Christina, Stölzel, Friedrich, Röllig, Christoph, Stelljes, Matthias, Gaidzik, Verena, Lauseker, Michael, Kriege, Oliver, Verbeek, Mareike, Unglaub, Julia Marie, Thol, Felicitas, Krause, Stefan W., Hänel, Mathias, Neuerburg, Charlotte, Vucinic, Vladan, Jehn, Christian-Friedrich, Severmann, Julia, Wass, Maxi, Fransecky, Lars, Chemnitz, Jens, Holtick, Udo, Schäfer-Eckart, Kerstin, Schröder, Josephine, Kraus, Sabrina, Krüger, William, Kaiser, Ulrich, Scholl, Sebastian, Koch, Kathrin, Henning, Lea, Kobbe, Guido, Haas, Rainer, Alakel, Nael, Röhnert, Maximilian-Alexander, Sockel, Katja, Hanoun, Maher, Platzbecker, Uwe, Holderried, Tobias A. W., Morgner, Anke, Heuser, Michael, Sauer, Tim, Götze, Katharina S., Wagner-Drouet, Eva, Döhner, Konstanze, Döhner, Hartmut, Schliemann, Christoph, Schetelig, Johannes, Bornhäuser, Martin, Germing, Ulrich, Schroeder, Thomas, and Middeke, Jan Moritz

Published
2021
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22. The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

Author

Thoene, Silvia, Mandal, Tamoghna, Vegi, Naidu M., Quintanilla-Martinez, Leticia, Rösler, Reinhild, Wiese, Sebastian, Metzeler, Klaus H., Herold, Tobias, Haferlach, Torsten, Döhner, Konstanze, Döhner, Hartmut, Schwarzmüller, Luisa, Klingmüller, Ursula, Buske, Christian, Rawat, Vijay P.S., and Feuring-Buske, Michaela

Published
2019
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23. Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group

Author

Rücker, Frank G., Agrawal, Mridul, Corbacioglu, Andrea, Weber, Daniela, Kapp-Schwoerer, Silke, Gaidzik, Verena I., Jahn, Nikolaus, Schroeder, Thomas, Wattad, Mohammed, Lübbert, Michael, Koller, Elisabeth, Kindler, Thomas, Götze, Katharina, Ringhoffer, Mark, Westermann, Jörg, Fiedler, Walter, Horst, Heinz A., Greil, Richard, Schroers, Roland, Mayer, Karin, Heinicke, Thomas, Krauter, Jürgen, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Paschka, Peter, Döhner, Hartmut, and Döhner, Konstanze

Published
2019
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24. Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Author

Schlenk, Richard F., Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, and Döhner, Hartmut

Published
2019
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26. Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Author

Jacquelin, Sebastien, Straube, Jasmin, Cooper, Leanne, Vu, Therese, Song, Axia, Bywater, Megan, Baxter, Eva, Heidecker, Matthew, Wackrow, Brad, Porter, Amy, Ling, Victoria, Green, Joanne, Austin, Rebecca, Kazakoff, Stephen, Waddell, Nicola, Hesson, Luke B., Pimanda, John E., Stegelmann, Frank, Bullinger, Lars, Döhner, Konstanze, Rampal, Raajit K., Heckl, Dirk, Hill, Geoffrey R., and Lane, Steven W.

Published
2018
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27. Measurable residual disease monitoring in patients with acute myeloid leukemia treated with lower‐intensity therapy: Roadmap from an ELN‐DAVID expert panel

Author

Ravandi, Farhad, primary, Cloos, Jacqueline, additional, Buccisano, Francesco, additional, Dillon, Richard, additional, Döhner, Konstanze, additional, Freeman, Sylvie D., additional, Hourigan, Christopher S., additional, Ossenkoppele, Gerrit J., additional, Roboz, Gail J., additional, Subklewe, Marion, additional, Thiede, Christian, additional, Arnhardt, Isabell, additional, Valk, Peter J. M., additional, Venditti, Adriano, additional, Wei, Andrew H., additional, Walter, Roland B., additional, and Heuser, Michael, additional

Published
2023
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28. Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML

Author

Thol, Felicitas, Gabdoulline, Razif, Liebich, Alessandro, Klement, Piroska, Schiller, Johannes, Kandziora, Christian, Hambach, Lothar, Stadler, Michael, Koenecke, Christian, Flintrop, Madita, Pankratz, Mira, Wichmann, Martin, Neziri, Blerina, Büttner, Konstantin, Heida, Bennet, Klesse, Sabrina, Chaturvedi, Anuhar, Kloos, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Gaidzik, Verena I., Bullinger, Lars, Fiedler, Walter, Heim, Albert, Hamwi, Iyas, Eder, Matthias, Krauter, Jürgen, Schlenk, Richard F., Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, and Heuser, Michael

Published
2018
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29. Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

Author

Schuurhuis, Gerrit J., Heuser, Michael, Freeman, Sylvie, Béné, Marie-Christine, Buccisano, Francesco, Cloos, Jacqueline, Grimwade, David, Haferlach, Torsten, Hills, Robert K., Hourigan, Christopher S., Jorgensen, Jeffrey L., Kern, Wolfgang, Lacombe, Francis, Maurillo, Luca, Preudhomme, Claude, van der Reijden, Bert A., Thiede, Christian, Venditti, Adriano, Vyas, Paresh, Wood, Brent L., Walter, Roland B., Döhner, Konstanze, Roboz, Gail J., and Ossenkoppele, Gert J.

Published
2018
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31. KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

Author

Jawhar, Mohamad, Döhner, Konstanze, Kreil, Sebastian, Schwaab, Juliana, Shoumariyeh, Khalid, Meggendorfer, Manja, Span, Lambert L. F., Fuhrmann, Stephan, Naumann, Nicole, Horny, Hans-Peter, Sotlar, Karl, Kubuschok, Boris, von Bubnoff, Nikolas, Spiekermann, Karsten, Heuser, Michael, Metzgeroth, Georgia, Fabarius, Alice, Klein, Stefan, Hofmann, Wolf-Karsten, Kluin-Nelemans, Hanneke C., Haferlach, Torsten, Döhner, Hartmut, Cross, Nicholas C. P., Sperr, Wolfgang R., Valent, Peter, and Reiter, Andreas

Published
2019
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32. Efficacy and safety of ruxolitinib in patients with newly-diagnosed polycythemia vera: futility analysis of the RuxoBEAT clinical trial of the GSG-MPN study group

Author

Koschmieder, Steffen, Isfort, Susanne, Jost, Philipp J., Parmentier, Stefani, Schaich, Markus, von Bubnoff, Nikolas, Stegelmann, Frank, Maurer, Angela, Crysandt, Martina, Gezer, Deniz, Kortmann, Maike, Franklin, Jeremy, Wolf, Dominik, Frank, Julia, Hellmich, Martin, Brümmendorf, Tim Henrik, German Study Group for Myeloproliferative Neoplasms (GSG-MPN), Heidel, Florian H., Hochhaus, Andreas, Schafhausen, Philippe, Griesshammer, Martin, Wolleschak, Denise, Platzbecker, Uwe, and Döhner, Konstanze

Subjects
ddc:610, Hematology, General Medicine
Abstract

Annals of hematology 102(2), 349-358 (2022). doi:10.1007/s00277-022-05080-7, Published by Springer, Berlin ; Heidelberg ; New York

Published
2022

34. P1542: RUXOLITINIB IN COVID-19 PATIENTS WITH DEFINED HYPERINFLAMMATION: THE RUXCOFLAM TRIAL

Author

Birndt, Sebastian, primary, Hammersen, Jakob, additional, Döhner, Konstanze, additional, Reuken, Philipp, additional, Sauerbrey, Paul, additional, Rosée, Felicitas La, additional, Pfirrmann, Markus, additional, Fabisch, Christian, additional, Illerhaus, Gerald, additional, Weiß, Manfred, additional, Träger, Karl, additional, Bremer, Hinrich, additional, Drömann, Daniel, additional, Schneider, Sylke, additional, Rosee, Paul La, additional, and Hochhaus, Andreas, additional

Published
2023
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35. S136: ANALYSIS OF FACTORS ASSOCIATED WITH LONG-TERM SURVIVAL IN A LARGE ACUTE PROMYELOCYTIC LEUKEMIA (APL) PATIENT COHORT: A HARMONY ALLIANCE STUDY

Author

Guarnera, Luca, primary, Lehmann, Soren, additional, Döhner, Konstanze, additional, Döhner, Hartmut, additional, Ossenkoppele, Gert, additional, Russell, Nigel, additional, Dillon, Richard, additional, Platzbecker, Uwe, additional, Vignetti, Marco, additional, la Sala, Edoardo, additional, Villaverde, Angela, additional, Tur, Laura, additional, Hernández Rivas, Jesus, additional, and Teresa Voso, Maria, additional

Published
2023
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36. P440: ENHANCER HIJACKING IN COMPLEX-KARYOTYPE AML

Author

Sollier, Etienne, primary, Riedel, Anna, additional, Kelly, Katherine, additional, Weichenhan, Dieter, additional, Jahn, Ekaterina, additional, Döhner, Konstanze, additional, Döhner, Hartmut, additional, Ernst, Aurélie, additional, Lutsik, Pavlo, additional, and Plass, Christoph, additional

Published
2023
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37. S120: MNX1-ACTIVATING ENHANCER HIJACKING EVENTS IN ACUTE MYELOID LEUKEMIA WITH DELETIONS ON CHROMOSOME 7Q

Author

Riedel, Anna, primary, Wierzbińska, Justyna A., additional, Toprak, Umut H., additional, Touzart, Aurore, additional, Sollier, Etienne, additional, Kelekçi, Simge, additional, Kelly, Katherine, additional, Weichenhan, Dieter, additional, Pejkovska, Anastasija, additional, Goyal, Ashish, additional, Meinen, Charlotte, additional, Schlesner, Matthias, additional, Westermann, Frank, additional, Brors, Benedikt, additional, Bullinger, Lars, additional, Greif, Philipp, additional, Lübbert, Michael, additional, Heidel, Florian, additional, Fischer, Thomas, additional, Gebhard, Claudia, additional, Schlegelberger, Brigitte, additional, Göhring, Gudrun, additional, Behrens, Yvonne, additional, Jahn, Ekaterina, additional, Döhner, Hartmut, additional, Döhner, Konstanze, additional, Delwel, Ruud, additional, Lutsik, Pavlo, additional, Lipka, Daniel B., additional, and Plass, Christoph, additional

Published
2023
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38. P417: GENOMIC LANDSCAPE AND PROGNOSIS IN OLDER ACUTE MYELOID LEUKEMIA PATIENTS NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY

Author

Jahn, Ekaterina, primary, Saadati, Maral, additional, Fenaux, Pierre, additional, Gobbi, Marco, additional, Roboz, Gail, additional, Bullinger, Lars, additional, Lutsik, Pavlo, additional, Riedel, Anna, additional, Plass, Christoph, additional, Jahn, Nikolaus, additional, Walter, Claudia, additional, Holzmann, Karlheinz, additional, Hao, Yong, additional, Naim, Sue, additional, Schreck, Nicholas, additional, Krzykalla, Julia, additional, Benner, Axel, additional, Keer, Harold, additional, Azab, Mohammad, additional, Döhner, Konstanze, additional, and Döhner, Hartmut, additional

Published
2023
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39. S135: NEXT-GENERATION SEQUENCING-BASED MEASURABLE RESIDUAL DISEASE MONITORING IN ACUTE MYELOID LEUKEMIA WITH FLT3 INTERNAL TANDEM DUPLICATION TREATED WITH INTENSIVE CHEMOTHERAPY PLUS MIDOSTAURIN

Author

Rücker, Frank G, primary, Bullinger, Lars, additional, Cocciardi, Sibylle, additional, Skambraks, Sabrina, additional, Luck, Tamara J, additional, Weber, Daniela, additional, Schneider, Isabelle, additional, Corbacioglu, Andrea, additional, Gaidzik, Verena I, additional, Jahn, Ekaterina, additional, Jahn, Nikolaus, additional, Kapp-Schwoerer, Silke, additional, Schrade, Anika, additional, Theis, Frauke, additional, Fiedler, Walter, additional, Salih, Helmut R, additional, Wulf, Gerald, additional, Salwender, Hans, additional, Schroeder, Thomas, additional, Götze, Katharina S, additional, Kindler, Thomas, additional, Lübbert, Michael, additional, Schlenk, Richard F, additional, Thol, Felicitas, additional, Heuser, Michael, additional, Ganser, Arnold, additional, Döhner, Hartmut, additional, and Döhner, Konstanze, additional

Published
2023
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41. P422: TARGETING THE WT1MUT-MIR-193A TRANSCRIPTIONAL AXIS WITH INT-1B3, A NOVEL LIPID NANOPARTICLE-FORMULATED MIR-193A-3P MIMIC IN ACUTE MYELOID LEUKEMIA

Author

Yang, Xining, primary, Krowiorz, Kathrin, additional, Buelow, Daelynn, additional, Bhayadia, Raj, additional, Kohlschmidt, Jessica, additional, Nicolet, Deedra, additional, Maetzig, Tobias, additional, Pabst, Caroline, additional, Hui, Jeremy, additional, Shad, Arshia, additional, Gao, Sharon, additional, Stephenson, Maria, additional, Wei Wu, Si, additional, van den Bosch, Marion, additional, Escano, Leo, additional, Lock, Frances, additional, Panahi, Afsaneh, additional, Macphee, Liam, additional, Maksakova, Irina, additional, Amoah, Amanda, additional, Döhner, Konstanze, additional, Fogelstrand, Linda, additional, Eisfeld, Ann-Kathrin, additional, Yahyanejad, Sanaz, additional, Janicot, Michel, additional, Klusmann, Jan-Henning, additional, Baker, Sharyn, additional, Oakes, Christopher, additional, Rouhi, Arefeh, additional, and Kuchenbauer, Florian, additional

Published
2023
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42. Human Chromosome 7: DNA Sequence and Biology

Author

Scherer, Stephen W., Cheung, Joseph, MacDonald, Jeffrey R., Osborne, Lucy R., Nakabayashi, Kazuhiko, Herbrick, Jo-Anne, Carson, Andrew R., Parker-Katiraee, Layla, Skaug, Jennifer, Khaja, Razi, Zhang, Junjun, Hudek, Alexander K., Li, Martin, Haddad, May, Duggan, Gavin E., Fernandez, Bridget A., Kanematsu, Emiko, Gentles, Simone, Christopoulos, Constantine C., Choufani, Sanaa, Kwasnicka, Dorota, Zheng, Xiangqun H., Lai, Zhongwu, Nusskern, Deborah, Zhang, Qing, Gu, Zhiping, Lu, Fu, Zeesman, Susan, Nowaczyk, Malgorzata J., Teshima, Ikuko, Chitayat, David, Shuman, Cheryl, Weksberg, Rosanna, Zackai, Elaine H., Grebe, Theresa A., Cox, Sarah R., Kirkpatrick, Susan J., Rahman, Nazneen, Friedman, Jan M., Pelicci, Pier Giuseppe, Lo-Coco, Francesco, Belloni, Elena, Shaffer, Lisa G., Pober, Barbara, Morton, Cynthia C., Gusella, James F., Korf, Bruce R., Quade, Bradley J., Ligon, Azra H., Ferguson, Heather, Higgins, Anne W., Leach, Natalia T., Herrick, Steven R., Lemyre, Emmanuelle, Farra, Chantal G., Kim, Hyung-Goo, Summers, Anne M., Gripp, Karen W., Roberts, Wendy, Szatmari, Peter, Grzeschik, Karl-Heinz, Teebi, Ahmed, Minassian, Berge A., Kere, Juha, Armengol, Lluis, Pujana, Miguel Angel, Estivill, Xavier, Wilson, Michael D., Koop, Ben F., Tosi, Sabrina, Moore, Gudrun E., Boright, Andrew P., Zlotorynski, Eitan, Kerem, Batsheva, Kroisel, Peter M., Petek, Erwin, Oscier, David G., Mould, Sarah J., Döhner, Hartmut, Döhner, Konstanze, Rommens, Johanna M., Vincent, John B., Venter, J. Craig, Li, Peter W., Mural, Richard J., Adams, Mark D., and Tsui, Lap-Chee

Published
2003

45. Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia—results of the AMLSG 11-08 trial

Author

Paschka, Peter, Schlenk, Richard F, Weber, Daniela, Benner, Axel, Bullinger, Lars, Heuser, Michael, Gaidzik, Verena I, Thol, Felicitas, Agrawal, Mridul, Teleanu, Veronica, Lübbert, Michael, Fiedler, Walter, Radsak, Markus, Krauter, Jürgen, Horst, Heinz-A., Greil, Richard, Mayer, Karin, Kündgen, Andrea, Martens, Uwe, Heil, Gerhard, Salih, Helmut R, Hertenstein, Bernd, Schwänen, Carsten, Wulf, Gerald, Lange, Elisabeth, Pfreundschuh, Michael, Ringhoffer, Mark, Girschikofsky, Michael, Heinicke, Thomas, Kraemer, Doris, Göhring, Gudrun, Ganser, Arnold, Döhner, Konstanze, and Döhner, Hartmut

Published
2018
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46. Outcome of 129 Pregnancies in Polycythemia Vera Patients: A Report of the European LeukemiaNET

Author

Wille, Kai, primary, Brouka, Maja, additional, Bernhardt, Johannes, additional, Rüfer, Axel, additional, Niculescu-Mizil, Emilia, additional, Gotic, Mirjana, additional, Isfort, Susanne, additional, Koschmieder, Steffen, additional, Barbui, Tiziano, additional, Sadjadian, Parvis, additional, Becker, Tatjana, additional, Kolatzki, Vera, additional, Meixner, Raphael, additional, Marchi, Hannah, additional, Fuchs, Christiane, additional, Stegelmann, Frank, additional, Döhner, Konstanze, additional, Kiladjian, Jean-Jacques, additional, and Griesshammer, Martin, additional

Published
2023
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47. Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax

Author

Rausch, Johanna, primary, Dzama, Margarita M., additional, Dolgikh, Nadezda, additional, Stiller, Hanna L., additional, Bohl, Stephan R., additional, Lahrmann, Catharina, additional, Kunz, Kerstin, additional, Kessler, Linda, additional, Echchannaoui, Hakim, additional, Chen, Chun-Wei, additional, Kindler, Thomas, additional, Döhner, Konstanze, additional, Burrows, Francis, additional, Theobald, Matthias, additional, Sasca, Daniel, additional, and Kühn, Michael W.M., additional

Published
2023
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48. Palbociclib in Acute Leukemias With KMT2A-rearrangement: Results of AMLSG 23-14 Trial

Author

Gaidzik, Verena I., primary, Paschka, Peter, additional, Schlenk, Richard F., additional, Weber, Daniela, additional, Fröhling, Stefan, additional, Krämer, Alwin, additional, Wäsch, Ralph, additional, Westermann, Jörg, additional, Mayer, Karin, additional, de Wit, Maike, additional, Fiedler, Walter, additional, Benner, Axel, additional, Heuser, Michael, additional, Thol, Felicitas, additional, Döhner, Konstanze, additional, Ganser, Arnold, additional, and Döhner, Hartmut, additional

Published
2023
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49. Experience With IVDR Implementation in Three Diagnostic Laboratories: Messages to EU Health Institutions, Diagnostic Healthcare Payers, and Authorities

Author

Lubbers, Bart R., primary, Dombrink, Isabel, additional, Kalina, Tomas, additional, Hofmans, Mattias, additional, Bruun, Morten S., additional, Stanworth, Simon J., additional, Béné, Marie C., additional, Döhner, Konstanze, additional, Brüggemann, Monika, additional, Macintyre, Elizabeth, additional, and van Dongen, Jacques J.M., additional

Published
2023
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50. Experience with IVDR Implementation in Three Diagnostic Laboratories: Messages to EU Health Institutions, Diagnostic Healthcare Payers, and Authorities

Author

Lubbers, Bart R., Dombrink, Isabel, Kalina, Tomas, Hofmans, Mattias, Bruun, Morten S., Stanworth, Simon J., Béne, Marie C., Döhner, Konstanze, Brüggemann, Monika, Macintyre, Elizabeth A., Dongen, J. J. M. van, Lubbers, Bart R., Dombrink, Isabel, Kalina, Tomas, Hofmans, Mattias, Bruun, Morten S., Stanworth, Simon J., Béne, Marie C., Döhner, Konstanze, Brüggemann, Monika, Macintyre, Elizabeth A., and Dongen, J. J. M. van

Abstract

Regulation (EU) 2017/746 on in vitro diagnostic medical devices1 (IVDR) has been implemented with the aim to safeguard the quality of diagnostic tests in the EU, for example, by requiring robust proof of safety and performance. The IVDR is a product regulation mainly aimed at industry manufacturing and marketing medical devices. While IVDR-compliant diagnostic tests should predominantly be supplied by manufacturers, health institutions have the possibility of manufacturing and using in-house devices (IH-IVDs), provided they meet the Article 5(5) conditions and relevant general safety and performance requirements in Annex I. This “health institution exemption” concerns, for example, their quality management system (QMS), risk management, performance evaluation, and justification of IH-IVD use.2 The first significant task for diagnostic laboratories at health institutions, compliance with Annex I, has been applicable since May 2022, whereas other implementation timelines are shifted based on the December 2021 amendment of the IVDR.3,4

Published
2023

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