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1. Frequent productive cough: Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study

Author

Benhabib, Gabriel, Ruiz, Xavier Bocca, Olmo, Ricardo del, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Reddel, Helen, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Delfini Cançado, José Eduardo, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, Rabahi, Marcelo, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, FitzGerald, J. Mark, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, McIvor, Andrew, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Chen, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, Bueno, Carlos Matiz, Molina de Salazar, Dora, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Weinreich, Ulla, Bonniaud, Philippe, Brun, Olivier, Burgel, Pierre-Régis, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Devouassoux, Gilles, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Raherison, Chantal, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Aries, Sven Philip, Bals, Robert, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Papi, Alberto, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Hiromasa, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Javier, Ruth Cerino, Peregrina, Alfredo Domínguez, Corzo, Marco Fernández, Gonzalez, Efraín Montano, Ramírez-Venegas, Alejandra, Rendon, Adrian, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van den Berge, Maarten, van de Ven, Mario, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Ho Joo, Yoon, Hyoung-Kyu, García-Navarro, Alvar Agusti, Andújar, Rubén, Anoro, Laura, García, María Buendía, Mozo, Paloma Campo, Campos, Sergio, Maldonado, Francisco Casas, Martínez, Manuel Castilla, Serrano, Carolina Cisneros, Casanova, Lorena Comeche, Corbacho, Dolores, Del Campo Matías, Felix, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Setién, Pedro Gamboa, Clemente, Marta García, Núñez, Ignacio García, Robaina, Jose García, Salmones, Mercedes García, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Rivera, José Olaguibel, Pérez de Llano, Luis, Bastida, Ana Pueyo, Rañó, Ana, González-Moro, José Rodríguez, Reig, Albert Roger, Garrido, José Velasco, Curiac, Dan, Janson, Christer, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Harrison, Timothy, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jorgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Frank, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Chipps, Bradley, Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Hughes, Rod, Rapsomaniki, Eleni, Keen, Christina, Make, Barry J., Tomaszewski, Erin L., Müllerová, Hana, and Reddel, Helen K.

Published
2022
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2. The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Author

Benhabib, Gabriel, Mandhane, Piushkumar, Ruiz, Xavier Bocca, McIvor, Andrew, Olmo, Ricardo del, Pek, Bonavuth, Lisanti, Raul Eduardo, Petrella, Robert, Marino, Gustavo, Stollery, Daniel, Mattarucco, Walter, Chen, Meihua, Nogueira, Juan, Chen, Yan, Parody, Maria, Gu, Wei, Pascale, Pablo, Hui, Kim Ming Christopher, Rodriguez, Pablo, Li, Manxiang, Silva, Damian, Li, Shiyue, Svetliza, Graciela, Ma, Lijun, Victorio, Carlos F., Qin, Guangyue, Rolon, Roxana Willigs, Song, Weidong, Yañez, Anahi, Tan, Wei, Baines, Stuart, Tang, Yijun, Bowler, Simon, Wang, Chen, Bremner, Peter, Wang, Tan, Bull, Sheetal, Wen, Fuqiang, Carroll, Patrick, Wu, Feng, Chaalan, Mariam, Xiang, PingChao, Farah, Claude, Xiao, Zuke, Hammerschlag, Gary, Xiong, Shengdao, Hancock, Kerry, Yang, Jinghua, Harrington, Zinta, Yang, Jingping, Katsoulotos, Gregory, Zhang, Caiqing, Kim, Joshua, Zhang, Min, Langton, David, Zhang, Ping, Lee, Donald, Zhang, Wei, Peters, Matthew, Zheng, Xiaohe, Prassad, Lakshman, Zhu, Dan, Reddel, Helen, Bolivar Grimaldos, Fabio, Sajkov, Dimitar, Arboleda, Alejandra Cañas, Santiago, Francis, Bueno, Carlos Matiz, Simpson, Frederick Graham, Molina de Salazar, Dora, Tai, Sze, Bendstrup, Elisabeth, Thomas, Paul, Hilberg, Ole, Wark, Peter, Kjellerup, Carsten, Cançado, José Eduardo Delfini, Weinreich, Ulla, Cunha, Thúlio, Bonniaud, Philippe, Lima, Marina, Brun, Olivier, Cardoso, Alexandre Pinto, Burgel, Pierre-Régis, Rabahi, Marcelo, Chouaid, Christos, Anees, Syed, Couturaud, Francis, Bertley, John, de Blic, Jacques, Bell, Alan, Debieuvre, Didier, Cheema, Amarjit, Delsart, Dominique, Chouinard, Guy, Demaegdt, Axelle, Csanadi, Michael, Demoly, Pascal, Dhar, Anil, Deschildre, Antoine, Dhillon, Ripple, Devouassoux, Gilles, FitzGerald, J. Mark, Egron, Carole, Kanawaty, David, Falchero, Lionel, Kelly, Allan, Goupil, François, Killorn, William, Kessler, Romain, Landry, Daniel, Le Roux, Pascal, Luton, Robert, Mabire, Pascal, Mahay, Guillaume, Ide, Yumiko, Martinez, Stéphanie, Inomata, Minehiko, Melloni, Boris, Inoue, Hiromasa, Moreau, Laurent, Inoue, Koji, Raherison, Chantal, Inoue, Sumito, Riviere, Emilie, Kato, Motokazu, Roux-Claudé, Pauline, Kawasaki, Masayuki, Soulier, Michel, Kawayama, Tomotaka, Vignal, Guillaume, Kita, Toshiyuki, Yaici, Azzedine, Kobayashi, Kanako, Aries, Sven Philip, Koto, Hiroshi, Bals, Robert, Nishi, Koichi, Beck, Ekkehard, Saito, Junpei, Deimling, Andreas, Shimizu, Yasuo, Feimer, Jan, Shirai, Toshihiro, Grimm-Sachs, Vera, Sugihara, Naruhiko, Groth, Gesine, Takahashi, Ken-ichi, Herth, Felix, Tashimo, Hiroyuki, Hoheisel, Gerhard, Tomii, Keisuke, Kanniess, Frank, Yamada, Takashi, Lienert, Thomas, Yanai, Masaru, Mronga, Silke, Javier, Ruth Cerino, Reinhardt, Jörg, Domínguez Peregrina, Alfredo, Schlenska, Christian, Corzo, Marco Fernández, Stolpe, Christoph, Montano Gonzalez, Efraín, Teber, Ishak, Ramírez-Venegas, Alejandra, Timmermann, Hartmut, Rendon, Adrian, Ulrich, Thomas, Boersma, Willem, Velling, Peter, Djamin, R.S., Wehgartner-Winkler, Sabina, Eijsvogel, Michiel, Welling, Juergen, Franssen, Frits, Winkelmann, Ernst-Joachim, Goosens, Martijn, Barbetta, Carlo, Graat-Verboom, Lidwien, Braido, Fulvio, Veen, Johannes in 't, Cardaci, Vittorio, Janssen, Rob, Clini, Enrico Maria, Kuppens, Kim, Costantino, Maria Teresa, van den Berge, Maarten, Cuttitta, Giuseppina, van de Ven, Mario, di Gioacchino, Mario, Brunstad, Ole Petter, Fois, Alessandro, Einvik, Gunnar, Foschino-Barbaro, Maria Pia, Høines, Kristian Jong, Gammeri, Enrico, Khusrawi, Alamdar, Inchingolo, Riccardo, Oien, Torbjorn, Lavorini, Federico, Chang, Yoon-Seok, Molino, Antonio, Cho, Young Joo, Nucera, Eleonora, Hwang, Yong Il, Papi, Alberto, Kim, Woo Jin, Patella, Vincenzo, Koh, Young-Il, Pesci, Alberto, Lee, Byung-Jae, Ricciardolo, Fabio, Lee, Kwan-Ho, Rogliani, Paola, Lee, Sang-Pyo, Sarzani, Riccardo, Lee, Yong Chul, Vancheri, Carlo, Lim, Seong Yong, Vincenti, Rigoletta, Min, Kyung Hun, Endo, Takeo, Oh, Yeon-Mok, Fujita, Masaki, Park, Choon-Sik, Hara, Yu, Park, Hae-Sim, Horiguchi, Takahiko, Park, Heung-Woo, Hosoi, Keita, Rhee, Chin Kook, Yoon, Ho Joo, Morice, Alyn, Yoon, Hyoung-Kyu, Pandya, Preeti, García-Navarro, Alvar Agusti, Patel, Manish, Andújar, Rubén, Roy, Kay, Anoro, Laura, Sathyamurthy, Ramamurthy, García, María Buendía, Thiagarajan, Swaminathan, Mozo, Paloma Campo, Turner, Alice, Campos, Sergio, Vestbo, Jorgen, Maldonado, Francisco Casas, Wedzicha, Wisia, Castilla Martínez, Manuel, Wilkinson, Tom, Serrano, Carolina Cisneros, Wilson, Pete, Comeche Casanova, Lorena, Al-Asadi, Lo’Ay, Corbacho, Dolores, Anholm, James, Campo Matías, Felix Del, Averill, Frank, Echave-Sustaeta, Jose, Bansal, Sandeep, Corral, Gloria Francisco, Baptist, Alan, Gamboa Setién, Pedro, Campbell, Colin, García Clemente, Marta, Campos, Michael A., Núñez, Ignacio García, Chipps, Bradley, Robaina, Jose García, Crook, Gretchen, García Salmones, Mercedes, DeLeon, Samuel, Marín Trigo, Jose Maria, Eid, Alain, Fernandez, Marta Nuñez, Epstein, Ellen, Palomo, Sara Nuñez, Fritz, Stephen, Olaguibel Rivera, José, Harris, Hoadley, de Llano, Luis Pérez, Hewitt, Mitzie, Pueyo Bastida, Ana, Holguin, Fernando, Rañó, Ana, Hudes, Golda, Rodríguez González-Moro, José, Jackson, Richard, Reig, Albert Roger, Kaufman, Alan, Velasco Garrido, José, Kaufman, David, Curiac, Dan, Klapholz, Ari, Janson, Christer, Krishna, Harshavardhan, Lif-Tiberg, Cornelia, Lee, Daria, Luts, Anders, Lin, Robert, Råhlen, Lennart, Maselli-Caceres, Diego, Rustscheff, Stefan, Mehta, Vinay, Adams, Frances, Moy, James N., Bradman, Drew, Nwokoro, Ugo, Broughton, Emma, Parikh, Purvi, Cosgrove, John, Parikh, Sudhir, Flood-Page, Patrick, Perrino, Frank, Fuller, Elizabeth, Ruhlmann, James, Harrison, Timothy, Sassoon, Catherine, Hartley, David, Settipane, Russell A., Hattotuwa, Keith, Sousa, Daniel, Jones, Gareth, Sriram, Peruvemba, Lewis, Keir, Wachs, Richard, McGarvey, Lorcan, Golam, Sarowar Muhammad, Beasley, Richard, FitzGerald, J Mark, Harrison, Tim, Hughes, Rod, Müllerová, Hana, Olaguibel, José María, Rapsomaniki, Eleni, Reddel, Helen K., and Sadatsafavi, Mohsen

Published
2022
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3. Relationship between domestic smoking and metals and rare earth elements concentration in indoor PM2.5

Author

Drago, Gaspare, Perrino, Cinzia, Canepari, Silvia, Ruggieri, Silvia, L’Abbate, Luca, Longo, Valeria, Colombo, Paolo, Frasca, Daniele, Balzan, Martin, Cuttitta, Giuseppina, Scaccianoce, Gianluca, Piva, Giuseppe, Bucchieri, Salvatore, Melis, Mario, Viegi, Giovanni, Cibella, Fabio, Bilocca, David, Borg, Charles, Montefort, Stephen, Zammit, Christopher, Ferrante, Giuliana, L'Abbate, Luca, Grutta, Stefania La, Melis, Mario R., Minardi, Remo, Ristagno, Rosaria, and Rizzo, Gianfranco

Published
2018
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6. Frequent productive cough: Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study

Author

Hughes, Rod, primary, Rapsomaniki, Eleni, additional, Janson, Christer, additional, Keen, Christina, additional, Make, Barry J., additional, Burgel, Pierre-Régis, additional, Tomaszewski, Erin L., additional, Müllerová, Hana, additional, Reddel, Helen K., additional, Benhabib, Gabriel, additional, Ruiz, Xavier Bocca, additional, Olmo, Ricardo del, additional, Lisanti, Raul Eduardo, additional, Marino, Gustavo, additional, Mattarucco, Walter, additional, Nogueira, Juan, additional, Parody, Maria, additional, Pascale, Pablo, additional, Rodriguez, Pablo, additional, Silva, Damian, additional, Svetliza, Graciela, additional, Victorio, Carlos F., additional, Rolon, Roxana Willigs, additional, Yañez, Anahi, additional, Baines, Stuart, additional, Bowler, Simon, additional, Bremner, Peter, additional, Bull, Sheetal, additional, Carroll, Patrick, additional, Chaalan, Mariam, additional, Farah, Claude, additional, Hammerschlag, Gary, additional, Hancock, Kerry, additional, Harrington, Zinta, additional, Katsoulotos, Gregory, additional, Kim, Joshua, additional, Langton, David, additional, Lee, Donald, additional, Peters, Matthew, additional, Prassad, Lakshman, additional, Reddel, Helen, additional, Sajkov, Dimitar, additional, Santiago, Francis, additional, Simpson, Frederick Graham, additional, Tai, Sze, additional, Thomas, Paul, additional, Wark, Peter, additional, Delfini Cançado, José Eduardo, additional, Cunha, Thúlio, additional, Lima, Marina, additional, Cardoso, Alexandre Pinto, additional, Rabahi, Marcelo, additional, Anees, Syed, additional, Bertley, John, additional, Bell, Alan, additional, Cheema, Amarjit, additional, Chouinard, Guy, additional, Csanadi, Michael, additional, Dhar, Anil, additional, Dhillon, Ripple, additional, FitzGerald, J. Mark, additional, Kanawaty, David, additional, Kelly, Allan, additional, Killorn, William, additional, Landry, Daniel, additional, Luton, Robert, additional, Mandhane, Piushkumar, additional, McIvor, Andrew, additional, Pek, Bonavuth, additional, Petrella, Robert, additional, Stollery, Daniel, additional, Chen, Meihua, additional, Chen, Yan, additional, Gu, Wei, additional, Christopher Hui, Kim Ming, additional, Li, Manxiang, additional, Li, Shiyue, additional, Lijun, Ma, additional, Qin, Guangyue, additional, Song, Weidong, additional, Tan, Wei, additional, Tang, Yijun, additional, Wang, Chen, additional, Wang, Tan, additional, Wen, Fuqiang, additional, Wu, Feng, additional, Xiang, PingChao, additional, Xiao, Zuke, additional, Xiong, Shengdao, additional, Yang, Jinghua, additional, Yang, Jingping, additional, Zhang, Caiqing, additional, Zhang, Min, additional, Zhang, Ping, additional, Zhang, Wei, additional, Zheng, Xiaohe, additional, Zhu, Dan, additional, Grimaldos, Fabio Bolivar, additional, Arboleda, Alejandra Cañas, additional, Bueno, Carlos Matiz, additional, Molina de Salazar, Dora, additional, Bendstrup, Elisabeth, additional, Hilberg, Ole, additional, Kjellerup, Carsten, additional, Weinreich, Ulla, additional, Bonniaud, Philippe, additional, Brun, Olivier, additional, Chouaid, Christos, additional, Couturaud, Francis, additional, de Blic, Jacques, additional, Debieuvre, Didier, additional, Delsart, Dominique, additional, Demaegdt, Axelle, additional, Demoly, Pascal, additional, Deschildre, Antoine, additional, Devouassoux, Gilles, additional, Egron, Carole, additional, Falchero, Lionel, additional, Goupil, François, additional, Kessler, Romain, additional, Le Roux, Pascal, additional, Mabire, Pascal, additional, Mahay, Guillaume, additional, Martinez, Stéphanie, additional, Melloni, Boris, additional, Moreau, Laurent, additional, Raherison, Chantal, additional, Riviere, Emilie, additional, Roux-Claudé, Pauline, additional, Soulier, Michel, additional, Vignal, Guillaume, additional, Yaici, Azzedine, additional, Aries, Sven Philip, additional, Bals, Robert, additional, Beck, Ekkehard, additional, Deimling, Andreas, additional, Feimer, Jan, additional, Grimm-Sachs, Vera, additional, Groth, Gesine, additional, Herth, Felix, additional, Hoheisel, Gerhard, additional, Kanniess, Frank, additional, Lienert, Thomas, additional, Mronga, Silke, additional, Reinhardt, Jörg, additional, Schlenska, Christian, additional, Stolpe, Christoph, additional, Teber, Ishak, additional, Timmermann, Hartmut, additional, Ulrich, Thomas, additional, Velling, Peter, additional, Wehgartner-Winkler, Sabina, additional, Welling, Juergen, additional, Winkelmann, Ernst-Joachim, additional, Barbetta, Carlo, additional, Braido, Fulvio, additional, Cardaci, Vittorio, additional, Clini, Enrico Maria, additional, Costantino, Maria Teresa, additional, Cuttitta, Giuseppina, additional, di Gioacchino, Mario, additional, Fois, Alessandro, additional, Foschino-Barbaro, Maria Pia, additional, Gammeri, Enrico, additional, Inchingolo, Riccardo, additional, Lavorini, Federico, additional, Molino, Antonio, additional, Nucera, Eleonora, additional, Papi, Alberto, additional, Patella, Vincenzo, additional, Pesci, Alberto, additional, Ricciardolo, Fabio, additional, Rogliani, Paola, additional, Sarzani, Riccardo, additional, Vancheri, Carlo, additional, Vincenti, Rigoletta, additional, Endo, Takeo, additional, Fujita, Masaki, additional, Hara, Yu, additional, Horiguchi, Takahiko, additional, Hosoi, Keita, additional, Ide, Yumiko, additional, Inomata, Minehiko, additional, Inoue, Hiromasa, additional, Inoue, Koji, additional, Inoue, Sumito, additional, Kato, Motokazu, additional, Kawasaki, Masayuki, additional, Kawayama, Tomotaka, additional, Kita, Toshiyuki, additional, Kobayashi, Kanako, additional, Koto, Hiroshi, additional, Nishi, Koichi, additional, Saito, Junpei, additional, Shimizu, Yasuo, additional, Shirai, Toshihiro, additional, Sugihara, Naruhiko, additional, Takahashi, Ken-ichi, additional, Tashimo, Hiroyuki, additional, Tomii, Keisuke, additional, Yamada, Takashi, additional, Yanai, Masaru, additional, Javier, Ruth Cerino, additional, Peregrina, Alfredo Domínguez, additional, Corzo, Marco Fernández, additional, Gonzalez, Efraín Montano, additional, Ramírez-Venegas, Alejandra, additional, Rendon, Adrian, additional, Boersma, Willem, additional, Djamin, R.S., additional, Eijsvogel, Michiel, additional, Franssen, Frits, additional, Goosens, Martijn, additional, Graat-Verboom, Lidwien, additional, Veen, Johannes in 't, additional, Janssen, Rob, additional, Kuppens, Kim, additional, van den Berge, Maarten, additional, van de Ven, Mario, additional, Brunstad, Ole Petter, additional, Einvik, Gunnar, additional, Høines, Kristian Jong, additional, Khusrawi, Alamdar, additional, Oien, Torbjorn, additional, Chang, Yoon-Seok, additional, Cho, Young Joo, additional, Hwang, Yong Il, additional, Kim, Woo Jin, additional, Koh, Young-Il, additional, Lee, Byung-Jae, additional, Lee, Kwan-Ho, additional, Lee, Sang-Pyo, additional, Lee, Yong Chul, additional, Lim, Seong Yong, additional, Min, Kyung Hun, additional, Oh, Yeon-Mok, additional, Park, Choon-Sik, additional, Park, Hae-Sim, additional, Park, Heung-Woo, additional, Rhee, Chin Kook, additional, Yoon, Ho Joo, additional, Yoon, Hyoung-Kyu, additional, García-Navarro, Alvar Agusti, additional, Andújar, Rubén, additional, Anoro, Laura, additional, García, María Buendía, additional, Mozo, Paloma Campo, additional, Campos, Sergio, additional, Maldonado, Francisco Casas, additional, Martínez, Manuel Castilla, additional, Serrano, Carolina Cisneros, additional, Casanova, Lorena Comeche, additional, Corbacho, Dolores, additional, Del Campo Matías, Felix, additional, Echave-Sustaeta, Jose, additional, Corral, Gloria Francisco, additional, Setién, Pedro Gamboa, additional, Clemente, Marta García, additional, Núñez, Ignacio García, additional, Robaina, Jose García, additional, Salmones, Mercedes García, additional, Marín Trigo, Jose Maria, additional, Fernandez, Marta Nuñez, additional, Palomo, Sara Nuñez, additional, Rivera, José Olaguibel, additional, Pérez de Llano, Luis, additional, Bastida, Ana Pueyo, additional, Rañó, Ana, additional, González-Moro, José Rodríguez, additional, Reig, Albert Roger, additional, Garrido, José Velasco, additional, Curiac, Dan, additional, Lif-Tiberg, Cornelia, additional, Luts, Anders, additional, Råhlen, Lennart, additional, Rustscheff, Stefan, additional, Adams, Frances, additional, Bradman, Drew, additional, Broughton, Emma, additional, Cosgrove, John, additional, Flood-Page, Patrick, additional, Fuller, Elizabeth, additional, Harrison, Timothy, additional, Hartley, David, additional, Hattotuwa, Keith, additional, Jones, Gareth, additional, Lewis, Keir, additional, McGarvey, Lorcan, additional, Morice, Alyn, additional, Pandya, Preeti, additional, Patel, Manish, additional, Roy, Kay, additional, Sathyamurthy, Ramamurthy, additional, Thiagarajan, Swaminathan, additional, Turner, Alice, additional, Vestbo, Jorgen, additional, Wedzicha, Wisia, additional, Wilkinson, Tom, additional, Wilson, Pete, additional, Al-Asadi, Lo’Ay, additional, Anholm, James, additional, Averill, Frank, additional, Bansal, Sandeep, additional, Baptist, Alan, additional, Campbell, Colin, additional, Campos, Michael A., additional, Chipps, Bradley, additional, Crook, Gretchen, additional, DeLeon, Samuel, additional, Eid, Alain, additional, Epstein, Ellen, additional, Fritz, Stephen, additional, Harris, Hoadley, additional, Hewitt, Mitzie, additional, Holguin, Fernando, additional, Hudes, Golda, additional, Jackson, Richard, additional, Kaufman, Alan, additional, Kaufman, David, additional, Klapholz, Ari, additional, Krishna, Harshavardhan, additional, Lee, Daria, additional, Lin, Robert, additional, Maselli-Caceres, Diego, additional, Mehta, Vinay, additional, Moy, James N., additional, Nwokoro, Ugo, additional, Parikh, Purvi, additional, Parikh, Sudhir, additional, Perrino, Frank, additional, Ruhlmann, James, additional, Sassoon, Catherine, additional, Settipane, Russell A., additional, Sousa, Daniel, additional, Sriram, Peruvemba, additional, and Wachs, Richard, additional

Published
2022
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7. The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study

Author

Golam, Sarowar Muhammad, primary, Janson, Christer, additional, Beasley, Richard, additional, FitzGerald, J Mark, additional, Harrison, Tim, additional, Chipps, Bradley, additional, Hughes, Rod, additional, Müllerová, Hana, additional, Olaguibel, José María, additional, Rapsomaniki, Eleni, additional, Reddel, Helen K., additional, Sadatsafavi, Mohsen, additional, Benhabib, Gabriel, additional, Mandhane, Piushkumar, additional, Ruiz, Xavier Bocca, additional, McIvor, Andrew, additional, Olmo, Ricardo del, additional, Pek, Bonavuth, additional, Lisanti, Raul Eduardo, additional, Petrella, Robert, additional, Marino, Gustavo, additional, Stollery, Daniel, additional, Mattarucco, Walter, additional, Chen, Meihua, additional, Nogueira, Juan, additional, Chen, Yan, additional, Parody, Maria, additional, Gu, Wei, additional, Pascale, Pablo, additional, Hui, Kim Ming Christopher, additional, Rodriguez, Pablo, additional, Li, Manxiang, additional, Silva, Damian, additional, Li, Shiyue, additional, Svetliza, Graciela, additional, Ma, Lijun, additional, Victorio, Carlos F., additional, Qin, Guangyue, additional, Rolon, Roxana Willigs, additional, Song, Weidong, additional, Yañez, Anahi, additional, Tan, Wei, additional, Baines, Stuart, additional, Tang, Yijun, additional, Bowler, Simon, additional, Wang, Chen, additional, Bremner, Peter, additional, Wang, Tan, additional, Bull, Sheetal, additional, Wen, Fuqiang, additional, Carroll, Patrick, additional, Wu, Feng, additional, Chaalan, Mariam, additional, Xiang, PingChao, additional, Farah, Claude, additional, Xiao, Zuke, additional, Hammerschlag, Gary, additional, Xiong, Shengdao, additional, Hancock, Kerry, additional, Yang, Jinghua, additional, Harrington, Zinta, additional, Yang, Jingping, additional, Katsoulotos, Gregory, additional, Zhang, Caiqing, additional, Kim, Joshua, additional, Zhang, Min, additional, Langton, David, additional, Zhang, Ping, additional, Lee, Donald, additional, Zhang, Wei, additional, Peters, Matthew, additional, Zheng, Xiaohe, additional, Prassad, Lakshman, additional, Zhu, Dan, additional, Reddel, Helen, additional, Bolivar Grimaldos, Fabio, additional, Sajkov, Dimitar, additional, Arboleda, Alejandra Cañas, additional, Santiago, Francis, additional, Bueno, Carlos Matiz, additional, Simpson, Frederick Graham, additional, Molina de Salazar, Dora, additional, Tai, Sze, additional, Bendstrup, Elisabeth, additional, Thomas, Paul, additional, Hilberg, Ole, additional, Wark, Peter, additional, Kjellerup, Carsten, additional, Cançado, José Eduardo Delfini, additional, Weinreich, Ulla, additional, Cunha, Thúlio, additional, Bonniaud, Philippe, additional, Lima, Marina, additional, Brun, Olivier, additional, Cardoso, Alexandre Pinto, additional, Burgel, Pierre-Régis, additional, Rabahi, Marcelo, additional, Chouaid, Christos, additional, Anees, Syed, additional, Couturaud, Francis, additional, Bertley, John, additional, de Blic, Jacques, additional, Bell, Alan, additional, Debieuvre, Didier, additional, Cheema, Amarjit, additional, Delsart, Dominique, additional, Chouinard, Guy, additional, Demaegdt, Axelle, additional, Csanadi, Michael, additional, Demoly, Pascal, additional, Dhar, Anil, additional, Deschildre, Antoine, additional, Dhillon, Ripple, additional, Devouassoux, Gilles, additional, FitzGerald, J. Mark, additional, Egron, Carole, additional, Kanawaty, David, additional, Falchero, Lionel, additional, Kelly, Allan, additional, Goupil, François, additional, Killorn, William, additional, Kessler, Romain, additional, Landry, Daniel, additional, Le Roux, Pascal, additional, Luton, Robert, additional, Mabire, Pascal, additional, Mahay, Guillaume, additional, Ide, Yumiko, additional, Martinez, Stéphanie, additional, Inomata, Minehiko, additional, Melloni, Boris, additional, Inoue, Hiromasa, additional, Moreau, Laurent, additional, Inoue, Koji, additional, Raherison, Chantal, additional, Inoue, Sumito, additional, Riviere, Emilie, additional, Kato, Motokazu, additional, Roux-Claudé, Pauline, additional, Kawasaki, Masayuki, additional, Soulier, Michel, additional, Kawayama, Tomotaka, additional, Vignal, Guillaume, additional, Kita, Toshiyuki, additional, Yaici, Azzedine, additional, Kobayashi, Kanako, additional, Aries, Sven Philip, additional, Koto, Hiroshi, additional, Bals, Robert, additional, Nishi, Koichi, additional, Beck, Ekkehard, additional, Saito, Junpei, additional, Deimling, Andreas, additional, Shimizu, Yasuo, additional, Feimer, Jan, additional, Shirai, Toshihiro, additional, Grimm-Sachs, Vera, additional, Sugihara, Naruhiko, additional, Groth, Gesine, additional, Takahashi, Ken-ichi, additional, Herth, Felix, additional, Tashimo, Hiroyuki, additional, Hoheisel, Gerhard, additional, Tomii, Keisuke, additional, Kanniess, Frank, additional, Yamada, Takashi, additional, Lienert, Thomas, additional, Yanai, Masaru, additional, Mronga, Silke, additional, Javier, Ruth Cerino, additional, Reinhardt, Jörg, additional, Domínguez Peregrina, Alfredo, additional, Schlenska, Christian, additional, Corzo, Marco Fernández, additional, Stolpe, Christoph, additional, Montano Gonzalez, Efraín, additional, Teber, Ishak, additional, Ramírez-Venegas, Alejandra, additional, Timmermann, Hartmut, additional, Rendon, Adrian, additional, Ulrich, Thomas, additional, Boersma, Willem, additional, Velling, Peter, additional, Djamin, R.S., additional, Wehgartner-Winkler, Sabina, additional, Eijsvogel, Michiel, additional, Welling, Juergen, additional, Franssen, Frits, additional, Winkelmann, Ernst-Joachim, additional, Goosens, Martijn, additional, Barbetta, Carlo, additional, Graat-Verboom, Lidwien, additional, Braido, Fulvio, additional, Veen, Johannes in 't, additional, Cardaci, Vittorio, additional, Janssen, Rob, additional, Clini, Enrico Maria, additional, Kuppens, Kim, additional, Costantino, Maria Teresa, additional, van den Berge, Maarten, additional, Cuttitta, Giuseppina, additional, van de Ven, Mario, additional, di Gioacchino, Mario, additional, Brunstad, Ole Petter, additional, Fois, Alessandro, additional, Einvik, Gunnar, additional, Foschino-Barbaro, Maria Pia, additional, Høines, Kristian Jong, additional, Gammeri, Enrico, additional, Khusrawi, Alamdar, additional, Inchingolo, Riccardo, additional, Oien, Torbjorn, additional, Lavorini, Federico, additional, Chang, Yoon-Seok, additional, Molino, Antonio, additional, Cho, Young Joo, additional, Nucera, Eleonora, additional, Hwang, Yong Il, additional, Papi, Alberto, additional, Kim, Woo Jin, additional, Patella, Vincenzo, additional, Koh, Young-Il, additional, Pesci, Alberto, additional, Lee, Byung-Jae, additional, Ricciardolo, Fabio, additional, Lee, Kwan-Ho, additional, Rogliani, Paola, additional, Lee, Sang-Pyo, additional, Sarzani, Riccardo, additional, Lee, Yong Chul, additional, Vancheri, Carlo, additional, Lim, Seong Yong, additional, Vincenti, Rigoletta, additional, Min, Kyung Hun, additional, Endo, Takeo, additional, Oh, Yeon-Mok, additional, Fujita, Masaki, additional, Park, Choon-Sik, additional, Hara, Yu, additional, Park, Hae-Sim, additional, Horiguchi, Takahiko, additional, Park, Heung-Woo, additional, Hosoi, Keita, additional, Rhee, Chin Kook, additional, Yoon, Ho Joo, additional, Morice, Alyn, additional, Yoon, Hyoung-Kyu, additional, Pandya, Preeti, additional, García-Navarro, Alvar Agusti, additional, Patel, Manish, additional, Andújar, Rubén, additional, Roy, Kay, additional, Anoro, Laura, additional, Sathyamurthy, Ramamurthy, additional, García, María Buendía, additional, Thiagarajan, Swaminathan, additional, Mozo, Paloma Campo, additional, Turner, Alice, additional, Campos, Sergio, additional, Vestbo, Jorgen, additional, Maldonado, Francisco Casas, additional, Wedzicha, Wisia, additional, Castilla Martínez, Manuel, additional, Wilkinson, Tom, additional, Serrano, Carolina Cisneros, additional, Wilson, Pete, additional, Comeche Casanova, Lorena, additional, Al-Asadi, Lo’Ay, additional, Corbacho, Dolores, additional, Anholm, James, additional, Campo Matías, Felix Del, additional, Averill, Frank, additional, Echave-Sustaeta, Jose, additional, Bansal, Sandeep, additional, Corral, Gloria Francisco, additional, Baptist, Alan, additional, Gamboa Setién, Pedro, additional, Campbell, Colin, additional, García Clemente, Marta, additional, Campos, Michael A., additional, Núñez, Ignacio García, additional, Robaina, Jose García, additional, Crook, Gretchen, additional, García Salmones, Mercedes, additional, DeLeon, Samuel, additional, Marín Trigo, Jose Maria, additional, Eid, Alain, additional, Fernandez, Marta Nuñez, additional, Epstein, Ellen, additional, Palomo, Sara Nuñez, additional, Fritz, Stephen, additional, Olaguibel Rivera, José, additional, Harris, Hoadley, additional, de Llano, Luis Pérez, additional, Hewitt, Mitzie, additional, Pueyo Bastida, Ana, additional, Holguin, Fernando, additional, Rañó, Ana, additional, Hudes, Golda, additional, Rodríguez González-Moro, José, additional, Jackson, Richard, additional, Reig, Albert Roger, additional, Kaufman, Alan, additional, Velasco Garrido, José, additional, Kaufman, David, additional, Curiac, Dan, additional, Klapholz, Ari, additional, Krishna, Harshavardhan, additional, Lif-Tiberg, Cornelia, additional, Lee, Daria, additional, Luts, Anders, additional, Lin, Robert, additional, Råhlen, Lennart, additional, Maselli-Caceres, Diego, additional, Rustscheff, Stefan, additional, Mehta, Vinay, additional, Adams, Frances, additional, Moy, James N., additional, Bradman, Drew, additional, Nwokoro, Ugo, additional, Broughton, Emma, additional, Parikh, Purvi, additional, Cosgrove, John, additional, Parikh, Sudhir, additional, Flood-Page, Patrick, additional, Perrino, Frank, additional, Fuller, Elizabeth, additional, Ruhlmann, James, additional, Harrison, Timothy, additional, Sassoon, Catherine, additional, Hartley, David, additional, Settipane, Russell A., additional, Hattotuwa, Keith, additional, Sousa, Daniel, additional, Jones, Gareth, additional, Sriram, Peruvemba, additional, Lewis, Keir, additional, Wachs, Richard, additional, and McGarvey, Lorcan, additional

Published
2022
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10. Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study.

Author

Cuttitta, Giuseppina, Ferraro, Maria, Cibella, Fabio, Alfano, Pietro, Bucchieri, Salvatore, Patti, Angelo Maria, Muratori, Rosalba, Pace, Elisabetta, and Bruno, Andreina

Subjects
*AEROBIC capacity, *BODY composition, *IRISIN, *HAPTOGLOBINS, *ADIPOKINES, *CHRONIC obstructive pulmonary disease, *ADIPOSE tissues
Abstract

Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Although inflammatory markers, body composition, and nutritional status have a significant impact on pulmonary function, the real contribution of adipocytokines and myokines in COPD is still controversial. We aimed to evaluate the role played by the body composition, leptin, adiponectin, haptoglobin, and irisin on the functional exercise capacity, respiratory function, and quality of life (QoL) in COPD. In 25 COPD (20% GOLD-1; 60% GOLD-2; 20% GOLD-3) patients and 26 matched control subjects, we find that leptin, total adiponectin and haptoglobin are significantly increased whereas the 6 min walk test (6MWT) and physical functioning scores are significantly decreased in COPD versus controls. A significant positive relationship is found between leptin and fat mass and between 6MWT and the good health indicators of nutritional status. A significant inverse relationship is found between 6MWT and leptin and fat mass, FEV1 and haptoglobin, and irisin and haptoglobin. Phase angle and leptin level are significant predictors for functional exercise capacity assessed with 6MWT. Taken altogether, the results of this pilot study further support the role played by body composition and adipocytokines on exercise capacity respiratory function and QoL in COPD. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Prevalence and clinical features of most frequent phenotypes in the Italian COPD population: the CLIMA Study

Author

Dal Negro, Roberto W., primary, Carone, Mauro, additional, Cuttitta, Giuseppina, additional, Gallelli, Luca, additional, Pistolesi, Massimo, additional, Privitera, Salvatore, additional, Ceriana, Piero, additional, Pirina, Pietro, additional, Balbi, Bruno, additional, Vancheri, Carlo, additional, Gallo, Franca M., additional, Chetta, Alfredo, additional, Turco, Paola, additional, and CLIMA Study Group*, On behalf of the, additional

Published
2021
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13. Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study

Author

Blasi, Francesco, primary, Antonelli Incalzi, Raffaele, additional, Canonica, Giorgio Walter, additional, Schino, Pietro, additional, Cuttitta, Giuseppina, additional, Zullo, Alessandro, additional, Ori, Alessandra, additional, and Scichilone, Nicola, additional

Published
2021
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14. Indoor air quality in schools of a highly polluted south Mediterranean area

Author

Ruggieri, Silvia, Longo, Valeria, Perrino, Cinzia, Canepari, Silvia, Drago, Gaspare, L'Abbate, Luca, Balzan, Martin, Cuttitta, Giuseppina, Scaccianoce, Gianluca, Minardi, Remo, Viegi, Giovanni, Cibella, Fabio, Bilocca, David, Borg, Charles, Montefort, Stephen R., Zammit, Christopher, Bucchieri, Salvatore, Colombo, Paolo, Ferrante, Giuliana, La Grutta, Stefania, Melis, Mario Raphael, Piva, Giuseppe, Ristagno, Rosaria, Rizzo, Gianfranco, RESPIRA Project Group, Ruggieri S., Longo V., Perrino C., Canepari S., Drago G., L'Abbate L., Balzan M., Cuttitta G., Scaccianoce G., Minardi R., Viegi G., Cibella F., Bilocca D., Borg C., Montefort S., Zammit C., Bucchieri S., Colombo P., Ferrante G., La Grutta S., Melis M.R., Piva G., Ristagno R., and Rizzo G.

Subjects
Der p 1, Rural Population, endotoxin, Environmental Engineering, PM, 010504 meteorology & atmospheric sciences, Threshold limit value, air pollution, Nitrogen Dioxide, Air pollution, PM2.5, 010501 environmental sciences, medicine.disease_cause, complex mixtures, 01 natural sciences, indoor comfort parameters, Indoor air quality, indoor comfort parameter, Metals, Heavy, medicine, Humans, Mass concentration (chemistry), Relative humidity, Particle Size, heavy metals, Sicily, 0105 earth and related environmental sciences, Pollutant, Air Pollutants, Carbon Monoxide, Elemental composition, Settore ING-IND/11 - Fisica Tecnica Ambientale, Schools, Mediterranean Region, Temperature, Public Health, Environmental and Occupational Health, Dust, Humidity, Building and Construction, heavy metal, Ventilation, 2.5, Air Pollution, Indoor, Environmental chemistry, Environmental science, Mediterranean area, Particulate Matter, Environmental Monitoring
Abstract

This study aimed at surveying lower secondary schools in southern Italy, in a highly polluted area. A community close to an industrial area and three villages in rural areas was investigated. Indoor temperature, relative humidity (RH), gaseous pollutants (CO 2 and NO 2 ), selected biological pollutants in indoor dust, and the indoor/outdoor mass concentration and elemental composition of PM 2.5 were ascertained. Temperature and RH were within, or close to, the comfort range, while CO 2 frequently exceeded the threshold of 1000ppm, indicating inadequate air exchange rate. In all the classrooms, median NO 2 levels were above the WHO threshold value. Dermatophagoides p. allergen concentration was below the sensitizing threshold, while high endotoxin levels were detected in the classrooms, suggesting schools may produce significant risks of endotoxin exposure. Concentration and solubility of PM 2.5 elements were used to identify the sources of indoor particles. Indoor concentration of most elements was higher than outdoors. Resuspension was responsible for the indoor increase in soil components. For elements from industrial emission (Cd, Co, Ni, Pb, Sb, Tl, V), the indoor concentration depended on penetration from the outside. For these elements, differences in rural vs industrial concentrations were found, suggesting industrial sources may influence indoor air quality nearby schools.

Published
2019
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15. Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study

Author

Blasi,Francesco, Antonelli Incalzi,Raffaele, Canonica,Giorgio Walter, Schino,Pietro, Cuttitta,Giuseppina, Zullo,Alessandro, Ori,Alessandra, Scichilone,Nicola, Blasi,Francesco, Antonelli Incalzi,Raffaele, Canonica,Giorgio Walter, Schino,Pietro, Cuttitta,Giuseppina, Zullo,Alessandro, Ori,Alessandra, and Scichilone,Nicola

Abstract

Francesco Blasi, 1, 2 Raffaele Antonelli Incalzi, 3 Giorgio Walter Canonica, 4 Pietro Schino, 5 Giuseppina Cuttitta, 6 Alessandro Zullo, 7 Alessandra Ori, 7 Nicola Scichilone 8 On behalf of STORICO study group 1Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy; 2Department of Pathophysiology and Transplantation, University of Milan, Milan, 20122, Italy; 3University Biomedical Campus of Rome, Rome, 00128, Italy; 4Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, Personalized Medicine, Asthma and Allergy, 20089, Rozzano, Milan, Italy; 5Miulli Hospital, Acquaviva delle Fonti, Bari, 70021, Italy; 6National Research Council, Palermo, 90146, Italy; 7Medineos Observational Research, Modena, 41123, Italy; 8DIBIMIS, University of Palermo, Palermo, 90127, ItalyCorrespondence: Francesco BlasiInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, via Francesco Sforza, 35, Milan, 20122, ItalyEmail STORICOpaperlongclinico@medineos.comIntroduction: Understanding clinical evolution of chronic obstructive pulmonary disease (COPD) is crucial for improving disease management.Materials and Methods: STORICO (NCT03105999), an Italian, multicenter, non-interventional, observational study conducted in 40 pulmonology centers, aimed to describe the 1-year clinical evolution and health status of clinicallbased phenotypes. Baseline and follow-up data of COPD subjects with a chronic bronchitis (CB) or emphysema (EM) phenotype were collected. The frequency of COPD symptoms during the 24 hours (gathered via the night-time, morning and day-time symptoms of COPD questionnaire) and the anxiety and depression levels (via the HADS Scale) were recorded at each visit.Results: A total of 261 CB and 159 EM patients wer

Published
2021

16. Relationship between Multimorbidity and Quality of Life in a Primary Care Setting: The Mediating Role of Dyspnea

Author

Alfano, Pietro, Cuttitta, Giuseppina, Audino, Palma, Fazio, Giovanni, La Grutta, Sabina, Marcantonio, Salvatore, Bucchieri, Salvatore, Snamid Palermo Cooperative Grp, Alfano P., Cuttitta G., Audino P., Fazio G., La Grutta S., Marcantonio S., and Bucchieri S.

Subjects
primary care, multimorbidity, quality of life, Airway obstruction, Dyspnea, Multimorbidity, Primary care, Quality of life, Medicine, General Medicine, dyspnea, airway obstruction, humanities
Abstract

Multimorbidity is known to impair Quality of Life (QoL) in patients in a primary setting. Poor QoL is associated with higher dyspnea perception. How multimorbidity and dyspnea perception are related to QoL needs clarification. The aim of the present study is to evaluate the mediating role of dyspnea perception in the relationship between multimorbidity and QoL in adults with and without airflow obstruction in a primary care setting. Seventeen general practitioners participated in the study: a total of 912 adult patients attending the practitioner’s surgery for a generic consultation completed a preliminary respiratory screening; 566 of them answered a respiratory questionnaire between January and June 2014, and 259 of the latter (148 M, aged 40–88) agreed to go through all the of procedures including spirometry, the IMCA and QoL (SF-36 through Physical Health “PCS” and Mental Health components) questionnaires, evaluation of comorbidities and the mMRC Dyspnea Scale. For screening purpose, a cut-off of FEV1/FVC < 70% was considered a marker of airflow obstruction (AO). Of the sample, 25% showed airflow obstruction (AO). No significant difference in mMRC score regarding the number of comorbidities and the PCS was found between subjects with and without AO. Multimorbidity and PCS were inversely related in subjects with (p < 0.001) and without AO (p < 0.001); mMRC and PCS were inversely related in subjects with (p = 0.001) and without AO (p < 0.001). A mediation analysis showed that the relation between number of comorbidities and PCS was totally mediated by mMRC in subjects with AO and partially in subjects without AO. We conclude that the effect of multimorbidity on PCS is totally mediated by mMRC only in AO. Detecting and monitoring mMRC in a primary care setting may be a useful indicator for evaluating a patient’s global health.

Published
2022
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17. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

Author

Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio Walter, Schino P, Cuttitta G, Foschino MP, Prediletto R, Tranfa C, Zappa MC, Patriciello P, Labate L, Mariotta S, Nava S, Vatrella A, Mastroberardino M, Sarzani R, Iuliano A, Maggi L, Zedda A, Pesci A, Sera G, Nicolini A, Salvatore Walter DD, Forte S, Mario DD, Rivolta F, Ferliga M, Raco AF, Luigi DR, Cabibbo G, Maselli R, Gulotta C, Nardini S, Guffanti EE, Castellani W, Triolo L, Passalacqua G, Beghè B, Salvatore LC, Faccini E, Atzeni E, Tazza R, Giamesio P., Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M.P., Prediletto R., Tranfa C.M.E., Zappa M.C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D.D., Forte S., Mario D.D., Rivolta F., Ferliga M., Raco A.F., Luigi D.R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E.E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L.C., Faccini E., Atzeni E., Tazza R., Giamesio P., Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio, Walter, Foschino, Mp, Zappa, Mc, Salvatore Walter, Dd, Mario, Dd, Raco, Af, Luigi, Dr, Guffanti, Ee, Beghè, B, Salvatore, Lc, and Giamesio, P.

Subjects
Male, Chronic bronchitis, Time Factors, Health Status, Anxiety, Hospital Anxiety and Depression Scale, Severity of Illness Index, Health Statu, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Surveys and Questionnaires, Forced Expiratory Volume, Clinical phenotype, Medicine, Surveys and Questionnaire, Respiratory function, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Lung, Depression (differential diagnoses), COPD, Depression, Middle Aged, Circadian Rhythm, Phenotype, Italy, Female, medicine.symptom, 24-hour symptoms, Clinical phenotype, Real-world, Respiratory function, Research Article, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic Obstructive, Time Factor, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Pulmonary Disease, 03 medical and health sciences, Internal medicine, Humans, Asthma, 24-hour symptoms, Real-world, Aged, Sleep, Quality of Life, lcsh:RC705-779, business.industry, Correction, lcsh:Diseases of the respiratory system, medicine.disease, 24-hour symptom, Prospective Studie, 030228 respiratory system, business
Abstract

Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George’s Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration Trial registration number: NCT03105999, date of registration: 10th April 2017.

Published
2019

23. 10-15 years old children living in Malta are at higher risk for developing allergic respiratory diseases than those living in Southern Sicily

Author

Drago, Gaspare, Balzan, Martin, Ruggieri, Silvia, Bilocca, David, Zammit, Christopher, Colombo, Paolo, Piva, Giuseppe, Cuttitta, Giuseppina, Bucchieri, Salvatore, Montefort, Stephen, Viegi, Giovanni, Cibella, Fabio, and Epidemiology of Asthma

Subjects
Atmospheric deposition -- Italy -- Sicily, Asthma -- Malta, Asthma -- Italy -- Sicily, Air -- Pollution -- Italy -- Sicily, Atmospheric deposition -- Malta, Air -- Pollution -- Malta
Abstract

Aim of the study was to evaluate the influence of living in highly polluted areas in Malta and in Sicily on reported allergic respiratory diseases in children. Malta has a very high population density while the petrochemical industry located close to Gela is one of the main sources of industrial air pollution in Sicily. In the context of RESPIRA Project, we evaluated 2,047 schoolchildren (972 M), aged 10-15 yrs, selected from 12 junior high schools of Southern Sicily (n=1,189 evaluated subjects) and 6 of Malta (n=858). Children′s parents fulfilled an ISAAC respiratory questionnaire. Rhinitis in the last 12 months was reported by 6.6% in Italy and 7.9% in Malta (p=.05); wheeze in the last 12 months (W12m) by 7.4% in Italy and 12.7% in Malta (p, N/A

Published
2016

24. Indoor and outdoor concentration of PM2.5 vanadium, nickel, and sulphur in three Mediterranean areas

Author

Cibella, Fabio, Perrino, Cinzia, Balzan, Martin, Ruggieri, Silvia, Bilocca, David, Drago, Gaspare, Zammit, Christopher, Minardi, Remo, Cuttitta, Giuseppina, Melis, Mario, Montefort, Stephen, and Viegi, Giovanni

Subjects
Atmospheric deposition, Petroleum -- Sulfur content, Particulate nitrate, Petroleum -- Vanadium content, Air -- Pollution
Abstract

Pollutants in particulate matter (PM) are associated with respiratory disorders. Data on indoor concentration of elemental chemical pollutants in highly polluted areas is scanty. In the context of RESPIRA Project, we evaluated both outdoor and indoor concentrations of air pollutants in the Mediterranean area. Gravimetric samples of PM with aerodynamic diameter, N/A

Published
2014

28. Correction to: Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study.

Author

Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio Walter, and STORICO study group

Subjects
CIRCADIAN rhythms, PERSONAL names, SCIENTIFIC observation, PHENOTYPES, CHRONOBIOLOGY disorders
Abstract

Following publication of the original article [1], the authors flagged that the article had been provided with the names of the authors (not including the STORICO study group) in the wrong order: the 'Given Names' and Family Names' were erroneously swapped around. [ABSTRACT FROM AUTHOR]

Published
2019
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29. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study.

Author

Nicola, Scichilone, Raffaele, Antonelli Incalzi, Francesco, Blasi, Pietro, Schino, Giuseppina, Cuttitta, Alessandro, Zullo, Alessandra, Ori, Giorgio Walter, Canonica, STORICO study group, Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, and Canonica, Giorgio Walter

Subjects
CHRONIC bronchitis, CIRCADIAN rhythms, OBSTRUCTIVE lung diseases, PHENOTYPES, QUALITY of life, SCIENTIFIC observation
Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype.Methods: The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George's Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded.Results: 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression.Conclusions: The findings highlight the primary classificatory role of nocturnal symptoms in COPD.Trial Registration: Trial registration number: NCT03105999 , date of registration: 10th April 2017. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Relationship between domestic smoking and metals and rare earth elements concentration in indoor PM2.5

Author

Gaspare Drago, Cinzia Perrino, Silvia Canepari, Silvia Ruggieri, Luca L’Abbate, Valeria Longo, Paolo Colombo, Daniele Frasca, Martin Balzan, Giuseppina Cuttitta, Gianluca Scaccianoce, Giuseppe Piva, Salvatore Bucchieri, Mario Melis, Giovanni Viegi, Fabio Cibella, David Bilocca, Charles Borg, Stephen Montefort, Christopher Zammit, Giuliana Ferrante, Luca L'Abbate, Stefania La Grutta, Mario R. Melis, Remo Minardi, Rosaria Ristagno, Gianfranco Rizzo, Drago, Gaspare, Perrino, Cinzia, Canepari, Silvia, Ruggieri, Silvia, L’Abbate, Luca, Longo, Valeria, Colombo, Paolo, Frasca, Daniele, Balzan, Martin, Cuttitta, Giuseppina, Scaccianoce, Gianluca, Piva, Giuseppe, Bucchieri, Salvatore, Melis, Mario, Viegi, Giovanni, Cibella, Fabio, Bilocca, David, Borg, Charle, Montefort, Stephen, Zammit, Christopher, Ferrante, Giuliana, La Grutta, Stefania, Minardi, Remo, Ristagno, Rosaria, and Rizzo, Gianfranco

Subjects
PM, 010504 meteorology & atmospheric sciences, PM2.5, indoor, cigarette smoke, heavy metals, Rare Earth Elements, respiratory health, Rare earth, chemistry.chemical_element, 010501 environmental sciences, complex mixtures, 01 natural sciences, Biochemistry, rare earth elements, Settore MED/38 - Pediatria Generale E Specialistica, Rare earth element, Lanthanum, Cigarette smoke, Indoor, Rare earth elements, Respiratory health, 0105 earth and related environmental sciences, General Environmental Science, Cadmium, Settore ING-IND/11 - Fisica Tecnica Ambientale, Heavy metals, Heavy metal, chemistry, 2.5, Environmental chemistry, Thallium
Abstract

Cigarette smoke is the main source of indoor chemical and toxic elements. Cadmium (Cd), Thallium (Tl), Lead (Pb) and Antimony (Sb) are important contributors to smoke-related health risks. Data on the association between Rare Earth Elements (REE) Cerium (Ce) and Lanthanum (La) and domestic smoking are scanty. To evaluate the relationship between cigarette smoke, indoor levels of PM2.5 and heavy metals, 73 children were investigated by parental questionnaire and skin prick tests. The houses of residence of 41 "cases" and 32 "controls" (children with and without respiratory symptoms, respectively) were evaluated by 48-hours PM2.5 indoor/outdoor monitoring. PM2.5 mass concentration was determined by gravimetry; the extracted and mineralized fractions of elements (As, Cd, Ce, La, Mn, Pb, Sb, Sr, Tl) were evaluated by ICP-MS. PM2.5 and Ce, La, Cd, and Tl indoor concentrations were higher in smoker dwellings. When corrected for confounding factors, PM2.5, Ce, La, Cd, and Tl were associated with more likely presence of respiratory symptoms in adolescents. We found that: i) indoor smoking is associated with increased levels of PM2.5, Ce, La, Cd, and Tl and ii) the latter with increased presence of respiratory symptoms in children

Published
2018
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31. Airway Obstruction in Primary Care Patients: Need for Implementing Spirometry Use.

Author

Bucchieri S, Alfano P, Audino P, Fazio G, Marcantonio S, Snamid Palermo Cooperative Group, and Cuttitta G

Abstract

(1) Background: To detect early airway obstruction in an adult primary care setting. (2) Methods: Seventeen general practitioners (GP) were involved. A total of 912 patients consulting their GPs over 40 years were recruited: 583 of them (323M) agreed to perform/undergo all the procedures: respiratory questionnaire, mMRC questionnaire, and spirometry. We identified four subgroups: physician COPD patients; physician asthma patients; asthma-COPD overlap syndrome patients; and no respiratory diagnosis subjects, on the basis of physician diagnosis. For screening purposes, an FEV1/FVC < 70% was considered a marker of airway obstruction (AO). (3) Results: Prevalence rates of COPD, A, and ACOS were 12.5%, 7.8%, and 3.6%, respectively. In the overall sample 16.3% showed airway obstruction: 26% mild, 56% moderate, 17% severe, and 1% very severe. In obstructed subjects, those reporting neither respiratory symptoms nor a physician’s respiratory diagnosis were 60% level I; 43% level II; 44% level III; and none level IV. Wheezing (p < 0.001), sputum (p = 0.01), older age (p < 0.0001), and male gender (p = 0.002) were the best predictors of airway obstruction. (4) Conclusions: A high prevalence of AO was found. In AO we found a high prevalence of subjects without respiratory symptoms or respiratory chronic diagnosis. Airway obstruction was predicted by the presence of wheezing, sputum, older age, and male gender.

Published
2022
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32. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study.

Author

Scichilone N, Antonelli Incalzi R, Blasi F, Schino P, Cuttitta G, Zullo A, Ori A, and Canonica GW

Subjects
Aged, Anxiety epidemiology, Depression epidemiology, Female, Forced Expiratory Volume, Health Status, Humans, Italy epidemiology, Male, Middle Aged, Phenotype, Prospective Studies, Pulmonary Disease, Chronic Obstructive epidemiology, Pulmonary Disease, Chronic Obstructive psychology, Severity of Illness Index, Sleep, Surveys and Questionnaires, Time Factors, Circadian Rhythm, Lung physiopathology, Pulmonary Disease, Chronic Obstructive physiopathology, Quality of Life
Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype., Methods: The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George's Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded., Results: 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression., Conclusions: The findings highlight the primary classificatory role of nocturnal symptoms in COPD., Trial Registration: Trial registration number: NCT03105999 , date of registration: 10th April 2017.

Published
2019
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