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2. Variation in the Care of Children with Inflammatory Bowel Disease Within and Across Canadian Provinces: A Multi-Province Population-Based Cohort Study

Author

Kuenzig,M Ellen, Stukel,Therese, Carroll,Matthew, Kaplan,Gilaad, Otley,Anthony, Singh,Harminder, Bitton,Alain, Fung,Stephen, Spruin,Sarah, Coward,Stephanie, Cui,Yunsong, Nugent,Zoann, Griffiths,Anne, Mack,David, Jacobson,Kevan, Nguyen,Geoffrey, Targownik,Laura, El-Matary,Wael, Bernstein,Charles, Dummer,Trevor, Jones,Jennifer, Lix,Lisa, Murthy,Sanjay, Peña-Sánchez,Juan Nicolás, Nasiri,Soheila, Benchimol,Eric, Kuenzig,M Ellen, Stukel,Therese, Carroll,Matthew, Kaplan,Gilaad, Otley,Anthony, Singh,Harminder, Bitton,Alain, Fung,Stephen, Spruin,Sarah, Coward,Stephanie, Cui,Yunsong, Nugent,Zoann, Griffiths,Anne, Mack,David, Jacobson,Kevan, Nguyen,Geoffrey, Targownik,Laura, El-Matary,Wael, Bernstein,Charles, Dummer,Trevor, Jones,Jennifer, Lix,Lisa, Murthy,Sanjay, Peña-Sánchez,Juan Nicolás, Nasiri,Soheila, and Benchimol,Eric

Abstract

M Ellen Kuenzig,1,2 Therese A Stukel,3,4 Matthew W Carroll,5 Gilaad G Kaplan,6 Anthony R Otley,7 Harminder Singh,8– 10 Alain Bitton,11 Stephen G Fung,12,13 Sarah Spruin,3,14 Stephanie Coward,6 Yunsong Cui,15 Zoann Nugent,8 Anne M Griffiths,1,2,16 David R Mack,12,13,17 Kevan Jacobson,18 Geoffrey C Nguyen,3,4,19 Laura E Targownik,19 Wael El-Matary,20 Charles N Bernstein,8,9 Trevor J B Dummer,21 Jennifer L Jones,15 Lisa M Lix,22 Sanjay K Murthy,14,23– 25 Juan Nicolás Peña-Sánchez,26 Soheila Nasiri,12,13 Eric I Benchimol1– 4,16 On behalf of the Canadian Gastro-Intestinal Epidemiology Consortium1SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (Sickkids), Toronto, Ontario, Canada; 2Child Health Evaluative Sciences, SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; 3ICES, Toronto, Ontario, Canada; 4Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; 5Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; 6Departments of Medicine & Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; 7Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada; 8Univeristy of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada; 9Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; 10Research Institute at CancerCare Manitoba, Winnipeg, Manitoba, Canada; 11McGill University Health Centre, Division of Gastroenterology and Hepatology, Montreal, Québec, Canada; 12CHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, CHEO, Ottawa, Ontario, Canada; 13CHEO Research Institute, Ottawa, Ontario, Canada; 14Ottawa Hospital Research Institute, Ottawa, On

Published
2024

3. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

4. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Published
2024

5. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Published
2024

6. Psychosocial factors, health behaviors and risk of cancer incidence:Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

7. Variation in the Care of Children with Inflammatory Bowel Disease Within and Across Canadian Provinces: A Multi-Province Population-Based Cohort Study

Author

Kuenzig, M Ellen, primary, Stukel, Therese, additional, Carroll, Matthew, additional, Kaplan, Gilaad, additional, Otley, Anthony, additional, Singh, Harminder, additional, Bitton, Alain, additional, Fung, Stephen, additional, Spruin, Sarah, additional, Coward, Stephanie, additional, Cui, Yunsong, additional, Nugent, Zoann, additional, Griffiths, Anne, additional, Mack, David, additional, Jacobson, Kevan, additional, Nguyen, Geoffrey, additional, Targownik, Laura, additional, El-Matary, Wael, additional, Bernstein, Charles, additional, Dummer, Trevor, additional, Jones, Jennifer, additional, Lix, Lisa, additional, Murthy, Sanjay, additional, Peña-Sánchez, Juan Nicolás, additional, Nasiri, Soheila, additional, and Benchimol, Eric, additional

Published
2024
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8. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Abstract

BACKGROUND: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium.METHODS: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2).RESULTS: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06-1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04-1.23).CONCLUSIONS: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. PREREGISTRATION NUMBER: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

9. Depression, anxiety, and the risk of cancer:An individual participant data meta-analysis

Author

van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., Ranchor, Adelita V., van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., and Ranchor, Adelita V.

Abstract

Background: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium. Methods: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2). Results: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06–1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04–1.23). Conclusions: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. Preregistration number: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

10. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

Trauma and Grief, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, Trauma and Grief, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Published
2023

11. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Brain, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma, Teyhan, Alison, Verschuren, MW, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, Cardiovasculaire Epidemiologie, MS Medische Oncologie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Brain, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma, Teyhan, Alison, Verschuren, MW, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Published
2023

15. Youth health care utilization in Nova Scotia: what is the role of age, sex and socio-economic status?

Author

Manos, Sarah H., Cui, Yunsong, MacDonald, Noni N., Parker, Louise, and Dummer, Trevor J.B.

Subjects
Influence, Demographic aspects, Forecasts and trends, Market trend/market analysis, Medical care utilization -- Demographic aspects -- Forecasts and trends, Social class -- Influence, Public health administration, Medical care -- Utilization, Social classes -- Influence
Abstract

Youth, who experience major changes in physical, mental and social development, (1,2) have distinct and unique health care needs related to this critical transition period in their development. (3,4) These [...], OBJECTIVE: Youth have distinct health care needs that are not always met within a framework designed for children or adults. In Canada, little attention has been given to how youth utilize health care services and limited data are available. The aim of this study was to identify whether age, sex, socio-economic status (SES) and geographic location were significant mediators of youth health care utilization in Nova Scotia. METHODS: The NSYOUTHS database comprises health care utilization information for all youth aged 12 to 24 years, resident in Nova Scotia between 1997 and 2007. We calculated health care utilization rates by provider, stratified by sex, age, SES, urban/rural residence and year. Negative binomial regression was used to model the variation in health care utilization by sex, SES and urban/rural location. RESULTS: Health care utilization declined over time and varied by age. Females were more frequent users of services. Youth from lower SES areas had fewer family physician contacts but more outpatient, emergency and inpatient contacts compared to those from higher SES areas. Rural residents had fewer family physician and emergency contacts but more outpatient contacts than youth from urban areas. Ten percent of the youth were responsible for 32% of all health care contacts, whereas 11% had no health care contacts. CONCLUSION: Specific subgroups, including youth from rural areas and of lower SES, utilize health care services differently than other youth. The challenge is to provide health care that is responsive to the needs of this heterogeneous population. Meeting this challenge requires accurate information on youth health care utilization. KEY WORDS: Youth; health service utilization; socio-economic status; geography La traduction du resume se trouve a la fin de l'article. OBJECTIF : En matiere de soins de sante, les jeunes ont des besoins distincts qui ne sont pas toujours satisfaits dans un cadre concu pour les enfants ou les adultes. Au Canada, on porte peu d'attention a la question de l'utilisation des services de sante par les jeunes, et les donnees disponibles a ce sujet sont limitees. Nous avons tente de determiner si l'age, le sexe, le statut socioeconomique (SSE) et l'emplacement geographique sont des mediateurs significatifs de l'utilisation des services de sante par les jeunes en Nouvelle-Ecosse. METHODE : La base de donnees NSYOUTHS contient de l'information sur l'utilisation des soins de sante par tous les jeunes de 12 a 24 ans qui residaient en Nouvelle-Ecosse entre 1997 et 2007. Nous avons calcule les taux d'utilisation des soins de sante par fournisseur et avons stratifie les resultats selon le sexe, l'age, le SSE, le lieu de residence (urbain ou rural) et l'annee. Par regression binomiale negative, nous avons modelise les ecarts dans l'utilisation des soins de sante selon le sexe, le SSE et le lieu de residence (urbain ou rural). RESULTATS : L'utilisation des soins de sante diminuait avec le temps et variait selon l'age. Les jeunes femmes et les filles y avaient recours plus frequemment que les jeunes hommes et les garcons. Les jeunes des regions de faible SSE avaient moins de contacts avec leurs medecins de famille, mais plus de contacts avec les soins ambulatoires, les urgences et les soins en etablissement comparativement aux jeunes des regions de SSE eleve. Les jeunes en milieu rural avaient moins de contacts avec leurs medecins de famille et les urgences, mais plus de contacts avec les soins ambulatoires que les jeunes des zones urbaines. Dix p. cent des jeunes ont eu 33% des contacts avec les soins de sante, tandis que 11% n'ont eu aucun contact avec les soins de sante. CONCLUSION : Certains sous-groupes, dont les jeunes des milieux ruraux et des regions de faible SSE, utilisent les services de sante differemment des autres jeunes. La difficulte est d'offrir des soins de sante adaptes aux besoins de cette population heterogene. Il faut pour cela avoir de l'information exacte sur l'utilisation des services de sante par les jeunes. MOTS CLES : jeunes; utilisation des services de sante; statut socioeconomique; geographie

Published
2014

16. Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses

Author

Tuijl, Lonneke A., primary, Voogd, Adri C., additional, Graeff, Alexander, additional, Hoogendoorn, Adriaan W., additional, Ranchor, Adelita V., additional, Pan, Kuan‐Yu, additional, Basten, Maartje, additional, Lamers, Femke, additional, Geerlings, Mirjam I., additional, Abell, Jessica G., additional, Awadalla, Philip, additional, Bakker, Marije F., additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Huisman, Martijn, additional, Huss, Anke, additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Onland‐Moret, N. Charlotte, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Portengen, Lützen, additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Rosmalen, Judith G. M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David M., additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Teyhan, Alison, additional, Vaartjes, Ilonca, additional, Willik, Kimberly D., additional, Leeuwen, Flora E., additional, Petersen, Rutger, additional, Verschuren, W. M. Monique, additional, Visseren, Frank, additional, Vermeulen, Roel, additional, and Dekker, Joost, additional

Published
2021
Full Text
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18. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

OBJECTIVES: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.METHODS: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).CONCLUSION: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

19. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

20. Psychosocial factors and cancer incidence (PSY-CA):Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

21. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

24. Psychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses.

Author

van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan‐Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T. F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, and Huisman, Martijn

Published
2021
Full Text
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