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IntroductionThe development of valid methods to diagnose prodromal Alzheimer's disease (AD) in adults with Down syndrome (DS) is one of the many goals of the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS).MethodsThe diagnostic utility of a modified Cued Recall Test (mCRT) was evaluated in 332 adults with DS ranging from 25 to 81 years of age. Total recall was selected a priori, as the primary indicator of performance. Multiple regression and receiver-operating characteristic (ROC) analyses were used to compare diagnostic groups.ResultsPerformance on the mCRT, as indicated by the total recall score, was highly sensitive to differences between diagnostic groups. ROC areas under the curve (AUCs) ranging from 0.843 to 0.955, were observed.DiscussionThe mCRT has strong empirical support for its use in clinical settings, as a valuable tool in studies targeting biomarkers of AD, and as a potential outcome measure in clinical trials targeting AD in this high-risk population.

Associative memory (AM) is the ability to bind new information into complex memory representations. Noninvasive brain stimulation (NIBS), especially transcranial electric stimulation (tES), has gained increased interest in research of associative memory (AM) and its impairments. To provide an overview of the current state of knowledge, we conducted a systematic review following PRISMA guidelines covering basic and clinical research. Out of 374 identified records, 41 studies were analyzed—twenty-nine in healthy young adults, six in the aging population, three comparing older and younger adults, as well as two studies on people with MCI, and one in people with Alzheimer's dementia. Studies using transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS) as well as oscillatory (otDCS) and high-definition protocols (HD-tDCS, HD-tACS) have been included. The results showed methodological heterogeneity in terms of study design, stimulation type, and parameters, as well as outcome measures. Overall, the results show that tES is a promising method for AM enhancement, especially if the stimulation is applied over the parietal cortex and the effects are assessed in cued recall paradigms. [ABSTRACT FROM AUTHOR]

Our ability to link related events could be supported either byconnecting their representations in memory, or by storing themseparately but integrating their content when later drawinginferences. Here, we adapted classic memory contingencyanalyses to develop and validate an integration index designedto tap stored representations. We conducted three pre-registered experiments adopting this metric. We found positiverecall dependency for associations experienced both within thesame and across different events. Compared to a conventionalinference test, we found that recall dependency was moresensitive to a manipulation of memory integration. Leveragingrecall dependency to investigate individual differencesrevealed that better memory for contextual detail wasassociated with faster inference judgments, consistent withhigh-fidelity representations of related memories—but only forpeople who tended to store memories separately. Ourapproach, thus, provides an important tool to illuminate howrelated events are represented in memory.

IntroductionFree recall tends to be better for names of animate concepts such as animals than for names of inanimate objects. In Popp and Serra’s 2016 article, the authors replicated this “animacy effect” in free recall but when participants studied words in pairs (animate-animate pairs intermixed with inanimate-inanimate pairs) and were tested with cued recall, performance was better for inanimate-inanimate pairs than for animate-animate pairs (“reverse animacy”). We tested the replicability of this surprising effect and one possible explanation for the effect (semantic similarity).MethodsOur Experiment 1 was a preregistered direct replication (N = 101) of Popp and Serra’s Experiment 1 (mixed-lists condition). In a second preregistered experiment conducted in four different samples (undergraduate N = 153, undergraduate N = 143, online Prolific N = 101, online Prolific/English-as-a-first-language N = 150), we manipulated the within-category semantic similarity of animal and object wordlists.ResultsAIn Experiment 1, just as in Popp and Serra, we observed an animacy effect for free recall and a reverse animacy effect for cued recall. Unlike Popp and Serra, we found that controlling for interference effects rendered the reverse animacy effect non-significant. We took this as evidence that characteristics of the stimulus sets (e.g., category structure, within-category similarity) may play a role in animacy and reverse animacy effects. In Experiment 2, in three out of our four samples, we observed reverse animacy effects when within-category similarity was higher for animals and when within-category similarity was equated for animals and objects.DiscussionOur results suggest that the reverse animacy effect observed in Popp and Serra’s 2016 article is a robust and replicable effect, but that semantic similarity alone cannot explain the effect.

Emotion regulation might have an impact on memory performance. Nevertheless, there is still no clear relationship between the type of emotion regulation strategy and the type of information recalled. An experiment was conducted involving 194 participants that performed an online task in which they had to recall three kinds of words (positive, negative, and neutral), with competitive recall cues (first letter), as the same cue was used for a word in each emotional category. They also answered three instruments for measuring emotion regulation (Emotion Regulation Questionnaire, ERQ), deficits in emotion regulation (Difficulties in Emotion Regulation Scale, DERS), and affective state (Positive and Negative Affect Schedule, PANAS). The results showed that participants with higher (vs. lower) levels in cognitive reappraisal performed better at recalling positive words. In turn, deficits in emotion regulation were linked to a weaker performance when recalling words with an emotional content, particularly the dimension of interference in recalling negative words. The results are discussed from the perspective of the processes involved in emotion regulation, while also considering the more stable skill-related aspects when controlling emotions. [ABSTRACT FROM AUTHOR]

Our performance varies throughout the day as a function of alignment with our circadian rhythms. The current experiment tested whether similar performance patterns can be observed in eyewitness memory performance. One-hundred-and-three morning-type and evening-type participants watched a stimulus event, provided a free report and answered cued questions in the morning and the evening hours, respectively. We expected eyewitness reports to be more detailed and more accurate at participants' circadian peaks than at circadian troughs. Contrary to our predictions, time of testing did not significantly affect quantity and accuracy of eyewitness statements. Future studies might investigate whether matching chronotype with time of day would be beneficial when encoding or retrieval conditions are suboptimal or when eyewitnesses are vulnerable. [ABSTRACT FROM AUTHOR]

This research aimed to clarify the role of the perceptual richness of words (PR) in the recall tasks. PR was operationalized as the number of sensory modalities through which an object can be perceived. Previously, we found that concepts experienced with many modalities (dog) were recalled more accurately in cued recall than those perceived with few modalities (rainbow) and abstract words. This finding fitted the Perceptual symbol system theory (PSST) and the Dual coding theory (DCT) predictions. We tested the PR effect in both cued (experiment 1-E1) and free recall tasks (experiment 2 - E2) in the present study. With careful stimuli manipulation of context availability and emotional valence and statistical control of arousal and relatedness, made to exclude their influence on recall, we tested alternative explanations of the concreteness effect offered by the relational-distinctiveness hypothesis. The additional perceptual codes improved recall accuracy in the cued recall task (E1), which was in line with the PSST and the DCT. This conclusion is straightforward: two critical groups of concrete words were matched for concreteness and visual perceptual strength. Thus, more accurate recall of concepts experienced with many modalities can be attributed to richer perceptual experience. However, the relational information was essential for recall accuracy in the free recall task (E2), as hypothesized by the relational-distinctiveness hypothesis. [ABSTRACT FROM AUTHOR]

Abstract Since the conception of pedagogical agents in multimedia environments, researchers have advocated for agents to be designed to exhibit social cues that prime the social interaction of the target audience. One powerful social cue has been agent gesturing. While most agents are created only to use deictic (pointing) gestures, there is recent evidence that agents that perform all gesture types (iconic, metaphoric, deictic, and beat) with enhanced frequency help foreign language users learn more procedural knowledge. Therefore, this research examines how all gesture types and different frequencies influence agent persona and learning outcomes when foreign language users learn declarative knowledge. The results indicated that the use of gestures, regardless of frequency, significantly increase agent persona. However, gesture frequency produced conflicting learning outcomes. While enhancing gestures were beneficial for cued recall and recognition, the average gesture condition was not, which indicates that the strength of social cues is important.

Context: Epidemiological studies have shown that consumption of dairy products reduces the risk of dementia and cognitive decline in older individuals. Tryptophan-tyrosine-related β-lactopeptides and their representative β-lactolin of glycine-threonine-tryptophan-tyrosine tetra-peptide have been identified as agents in dairy products, which improve cognitive function as well as memory function via the activation of the dopaminergic system in a mouse model of amnesia. Previous clinical trials have shown that supplementation with β-lactolin improves memory retrieval in healthy older adults. Specifically, β-lactolin improved the scores in some neuropsychological tests. However, the effects of β-lactolin on memory function have not been clarified. Objectives: The aim of this study was to evaluate the effect of β-lactolin on memory function using statistical methods. Data Sources: We searched the Web of Science, Cochrane Library, and JDream III until November 2021 to identify relevant randomized controlled trials for integrated analysis. Data Synthesis: Three randomized controlled trials evaluating the effect of β-lactolin on memory in healthy adults were selected for the integrated analysis. The results showed that the score of cued recall among the neuropsychological tests in the β-lactolin group was significantly higher than that in the placebo group (g=0.33; 95% CI: 0.10, 0.55). In addition, the total memory score was higher but this difference was not significant (g=0.17; 95% CI: −0.09, 0.43). Conclusions: Taken together, these results suggest that supplementation with β-lactolin improves cued recall in healthy older adults. [ABSTRACT FROM AUTHOR]

Since the conception of pedagogical agents in multimedia environments, researchers have advocated for agents to be designed to exhibit social cues that prime the social interaction of the target audience. One powerful social cue has been agent gesturing. While most agents are created only to use deictic (pointing) gestures, there is recent evidence that agents that perform all gesture types (iconic, metaphoric, deictic, and beat) with enhanced frequency help foreign language users learn more procedural knowledge. Therefore, this research examines how all gesture types and different frequencies influence agent persona and learning outcomes when foreign language users learn declarative knowledge. The results indicated that the use of gestures, regardless of frequency, significantly increase agent persona. However, gesture frequency produced conflicting learning outcomes. While enhancing gestures were beneficial for cued recall and recognition, the average gesture condition was not, which indicates that the strength of social cues is important. [ABSTRACT FROM AUTHOR]

An inability to recall details from an otherwise uneventful drive on a familiar route is a common experience to many. Whether this amnesia for everyday driving is because we don't actually form strong memories when we are driving on autopilot or whether this is because we simply can't find those memories when we try to later is an interesting question, not only for driving, but for memory and skilled performance more generally. The present study sought to determine whether recall could be aided by reinstating an auditory cue that was present during the drive. Twenty-five participants drove three 9 km routes on familiar roads and then were asked a series of questions about the details of the drives. Three auditory cues (music, radio documentary, or periodic verbal markers) and a visual cue were used as contextual stimuli during the drives and as post-drive recall cues. The music and verbal markers produced better recall than the radio documentary. Although proceduralised driving on a familiar road may make incidental details of the drive difficult to recall, those details are recoverable with a sufficiently robust recall cue.

Much evidence suggests that the angular gyrus (AnG) is involved in episodic memory, but its precise role has yet to be determined. We examined two possible accounts within the same experimental paradigm: the "cortical binding of relational activity" (CoBRA) account (Shimamura, 2011), which suggests that the AnG acts as a convergence zone that binds multimodal episodic features, and the subjectivity account (Yazar et al, 2012), which implicates AnG involvement in subjective mnemonic experience (such as vividness or confidence). fMRI was used during both encoding and retrieval of paired associates. During study, female and male human participants memorized picture-pairs of common objects (in the unimodal task) or of an object-picture and an environmental sound (in the crossmodal task). At test, they performed a cued-recall task and further indicated the vividness of their memory. During retrieval, BOLD activation in the AnG was greatest for vividly remembered associates, consistent with the subjectivity account. During encoding, the same effect of vividness was found, but this was further modulated by task: greater activations were associated with subsequent recall in the crossmodal than the unimodal task. Therefore, encoding data suggest an additional role to the AnG in crossmodal integration, consistent with its role at retrieval proposed by CoBRA. These results resolve some of the puzzles in the literature and indicate that the AnG can play different roles during encoding and retrieval as determined by the cognitive demands posed by different mnemonic tasks. [ABSTRACT FROM AUTHOR]

The sensory recruitment hypothesis states that visual short-term memory is maintained in the same visual cortical areas that initially encode a stimulus' features. Although it is well established that the distance between features in visual cortex determines their visibility, a limitation known as crowding, it is unknown whether short-term memory is similarly constrained by the cortical spacing of memory items. Here, we investigated whether the cortical spacing between sequentially presented memoranda affects the fidelity of memory in humans (of both sexes). In a first experiment, we varied cortical spacing by taking advantage of the log-scaling of visual cortex with eccentricity, presenting memoranda in peripheral vision sequentially along either the radial or tangential visual axis with respect to the fovea. In a second experiment, we presented memoranda sequentially either within or beyond the critical spacing of visual crowding, a distance within which visual features cannot be perceptually distinguished due to their nearby cortical representations. In both experiments and across multiple measures, we found strong evidence that the ability to maintain visual features in memory is unaffected by cortical spacing. These results indicate that the neural architecture underpinning working memory has properties inconsistent with the known behavior of sensory neurons in visual cortex. Instead, the dissociation between perceptual and memory representations supports a role of higher cortical areas such as posterior parietal or prefrontal regions or may involve an as yet unspecified mechanism in visual cortex in which stimulus features are bound to their temporal order. [ABSTRACT FROM AUTHOR]

Repeated testing during learning often improves later memory, which is often referred to as the testing effect. To clarify its boundary conditions, we examined whether the testing effect was selectively affected by covert (retrieved but not articulated) or overt (retrieved and articulated) response format. In Experiments 1 and 2, we compared immediate (5 min) and delayed (1 week) cued recall for paired associates following study-only, covert, and overt conditions, including two types of overt articulation (typing and writing). A clear testing effect was observed in both experiments, but with no selective effects of response format. In Experiments 3 and 4, we compared covert and overt retrieval under blocked and random list orders. The effect sizes were small in both experiments, but there was a significant effect of response format, with overt retrieval showing better final recall performance than covert retrieval. There were no significant effects of blocked vs. random list orders with respect to the testing effect produced. Taken together, these findings suggest that, under specific circumstances, overt retrieval may lead to a greater testing effect than that of covert retrieval, but because of small effect sizes, it appears that the testing effect is mainly the result of retrieval processes and that articulation has fairly little to add to its magnitude in a paired-associates learning paradigm.

We examined if apes spontaneously remember one-time, distinctive events across long delays when probed by discriminant cues. Apes witnessed an experimenter hide a cache of food, which they could then retrieve. They retrieved one of two food types; one more distinctive than the other. Two, 10 or 50 weeks later, the apes returned to the same enclosure and found a piece of the previously hidden food on the ground. An experimenter who had not hidden the food was also present. Apes immediately searched the location where the food was previously hidden (no food was here), showing recall of the event. One week later, apes returned to the same enclosure, with the same food on the ground, but now the experimenter that had hidden the food was present. Again, apes immediately searched the hiding location. Apes that had not witnessed the hiding event did not search. There was no significant effect of food type, and retention declined from exposure to the two-week delay, then levelled, consistent with the forgetting curve in humans (Ebbinghaus, H. 1964 Memory: a contribution to experimental psychology (transl. H.A. Ruger & C.E. Bussenvis). New York, NY: Dover. (Original work published 1885.)). This is the first study to show apes can recall a one-time, non-goal-directed event longer than two weeks ago and that apes' recall declines in accordance with a standard retention function. [ABSTRACT FROM AUTHOR]

Decades of research have investigated the effects of encoding strategies in the formation of associations in memory. Despite this, it is not known whether or how changes in the use of strategies within a brief time span may affect memory. For example, what is the effect on memory of abandoning a recent strategy or switching to a different strategy? The present study systematically varied the strategies used by participants in two closely-spaced associative memory tasks. Results indicated that intentional abandonment of a verbal (sentence-generation) strategy had disproportionately negative consequences on memory for semantically unrelated word pairs. The findings suggest that memory encoding is affected by differences in strategy use across recent memory tasks, and have implications for effective use of memory strategies in practical settings. [ABSTRACT FROM AUTHOR]

Evidence supports the benefits of effortful processing in strengthening retention of newly learned material. The present study compared two forms of effortful processing, uncued (free) recall and cued recall, under both open and closed book conditions, on both immediate and delayed (one-week) test performance. Participants read a section of a child psychology text and then completed either an uncued recall task in which they typed as much information as they could recall, or a cued recall task, in which they typed answers to study questions. Recall was conducted under open versus closed book conditions. No differences between cued and uncued conditions were obtained, but participants performed better on immediate test performance in the open book condition. No significant effects were found at delayed assessment. The results point to a short-term advantage of effortful review of text materials performed with access to study materials.

This study starts from the observation that current empirical research on students’ processing strategies in higher education has mainly focused on the use of self-report instruments to measure students’ general preferences towards processing strategies. In contrast, there is a rather limited use of more direct and online observation techniques to uncover differences in processing strategies at a task specific level. We based our study on one of the most influential studies in the domain of Students’ Approaches to Learning (SAL) (Marton, Dahlgren, Säljö, & Svensson, 1975). In our exploratory experiment we used eye tracking followed by a cued recall to investigate how students use processing strategies in learning from expository text. Nineteen university students participated in the experiment. Results suggested that students in the deep condition did not look longer at the essentials in the text compared with students in the surface condition, but that they processed them in a more deep way. In our sample, students in the surface condition looked longer at facts and details and also reported repeating these facts and details more often. We suggest that the combination of eye tracking followed by a cued recall is a promising tool to investigate students’ processing strategies since not all differences in processing strategies are reflected in overt eye movement behaviour. The current methodology allows researchers in the domain of SAL to complement and extend the present knowledge base that has accumulated through years of research with self-report questionnaires and interviews on students’ general preferences towards processing strategies.

Introduction: Free recall tends to be better for names of animate concepts such as animals than for names of inanimate objects. In Popp and Serra's 2016 article, the authors replicated this "animacy effect" in free recall but when participants studied words in pairs (animate-animate pairs intermixed with inanimate-inanimate pairs) and were tested with cued recall, performance was better for inanimate-inanimate pairs than for animate-animate pairs ("reverse animacy"). We tested the replicability of this surprising effect and one possible explanation for the effect (semantic similarity)., Methods: Our Experiment 1 was a preregistered direct replication ( N = 101) of Popp and Serra's Experiment 1 (mixed-lists condition). In a second preregistered experiment conducted in four different samples (undergraduate N = 153, undergraduate N = 143, online Prolific N = 101, online Prolific/English-as-a-first-language N = 150), we manipulated the within-category semantic similarity of animal and object wordlists., Results: AIn Experiment 1, just as in Popp and Serra, we observed an animacy effect for free recall and a reverse animacy effect for cued recall. Unlike Popp and Serra, we found that controlling for interference effects rendered the reverse animacy effect non-significant. We took this as evidence that characteristics of the stimulus sets (e.g., category structure, within-category similarity) may play a role in animacy and reverse animacy effects. In Experiment 2, in three out of our four samples, we observed reverse animacy effects when within-category similarity was higher for animals and when within-category similarity was equated for animals and objects., Discussion: Our results suggest that the reverse animacy effect observed in Popp and Serra's 2016 article is a robust and replicable effect, but that semantic similarity alone cannot explain the effect., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Mah, Grannon, Campbell, Tamburri, Jamieson and Lindsay.)

Recollection of past events has been associated with the core recollection network comprising the posterior medial temporal lobe and parietal regions, as well as the medial prefrontal cortex (mPFC). The development of the brain basis for recollection is understudied. In a sample of adults (n = 22; 18-25 years) and children (n = 23; 9-13 years), the present study aimed to address this knowledge gap using a cued recall paradigm, known to elicit recollection experience. Successful recall was associated with activations in regions of the core recollection network and frontoparietal network. Adults exhibited greater successful recall activations compared with children in the precuneus and right angular gyrus. In contrast, similar levels of successful recall activations were observed in both age groups in the mPFC. Group differences were also seen in the hippocampus and lateral frontal regions. These findings suggest that the engagement of the mPFC in episodic retrieval may be relatively early maturing, whereas the contribution to episodic retrieval of more posterior regions such as the precuneus and angular gyrus undergoes more protracted maturation., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Butler (2010: Experiment 3) showed that retrieval practice enhanced transfer to a new knowledge domain compared to rereading. The first experiment of the present study was a direct replication of Butler's third experiment. Participants studied text passages and then either reread them three times or went through three cycles of cued recall questions (i.e., retrieval practice) with feedback. As in Butler's (2010) experiment, an advantage of retrieval practice on the final far transfer test emerged after 1 week. Additionally, we observed an advantage of retrieval practice on the final test administered after 5 min. However, these advantages might have been due to participants in the retrieval practice condition receiving focused exposure to the key information (i.e., the feedback) that was needed to answer the final test questions. We therefore conducted a second experiment in which we included the retrieval practice condition and the reread condition from our first experiment, as well as a new reread-plus-statements condition. In the reread-plus-statements condition, participants received focused exposure to the key information after they had reread a text. As in Experiment 1, we found a large effect on far transfer when retrieval practice was compared to rereading. However, this effect was substantially reduced when retrieval practice was compared to the reread-plus-statements condition. Taken together, the results of the present experiments demonstrate that Butler's (2010) testing effect in far transfer is robust. Moreover, focused exposure to key information appears to be a significant factor in this far transfer testing effect. [ABSTRACT FROM AUTHOR]

Evidence supports the benefits of effortful processing in strengthening retention of newly learned material. The present study compared two forms of effortful processing, uncued (free) recall and cued recall, under both open and closed book conditions, on both immediate and delayed (one-week) test performance. Participants read a section of a child psychology text and then completed either an uncued recall task in which they typed as much information as they could recall, or a cued recall task, in which they typed answers to study questions. Recall was conducted under open versus closed book conditions. No differences between cued and uncued conditions were obtained, but participants performed better on immediate test performance in the open book condition. No significant effects were found at delayed assessment. The results point to a short-term advantage of effortful review of text materials performed with access to study materials. [ABSTRACT FROM AUTHOR]

According to prescriptive decision theories, the generation of options for choice is a central aspect of decision making. A too narrow representation of the problem may indeed limit the opportunity to evaluate promising options. However, despite the theoretical and applied significance of this topic, the cognitive processes underlying option generation are still unclear. In particular, while a cued recall account of option generation emphasizes the role of memory and executive control, other theoretical proposals stress the importance of ideation processes based on various search and thinking processes. Unfortunately, relevant behavioral evidence on the cognitive processes underlying option generation is scattered and inconclusive. In order to reach a better understanding, we carried out an individual-differences study employing a wide array of cognitive predictors, including measures of episodic memory, semantic memory, cognitive control, and ideation fluency. The criterion tasks consisted of three different poorly-structured decision-making scenarios, and the participants were asked to generate options to solve these problems. The main criterion variable of the study was the number of valid options generated, but also the diversity and the quality of generated options were examined. The results showed that option generation fluency and diversity in the context of ill-structured decision making are supported by ideation ability even after taking into account the effects of individual differences in several other aspects of cognitive functioning. Thus, ideation processes, possibly supported by search and thinking processes, seem to contribute to option generation beyond basic associative memory retrieval. The findings of the study also indicate that generating more options may have multifaceted consequences for choice, increasing the quality of the best option generated but decreasing the mean quality of the options in the generated set.

The goal of this study was to test whether the accuracy of recall is influenced by the number of sensory modalities through which a concept can be experienced - a new variable closely related to word concreteness. Based on processing advantage of concepts that can be experienced through higher number of senses (fish) over the ones experienced through lower number of senses (moon), we hypothesized that the effect of number of senses will be observed in recall tasks, as well. In the first experiment, we presented pairs of related words to four groups of participants in the paired associate learning paradigm. Half of the participants were engaged in free recall, and half in cued recall. Each task was applied to two lists of stimuli. Within each list, half of the words were abstract, and half were concrete. Abstract words were identical across lists, whereas concrete words differed with respect to the number of modalities: one list consisted of concepts that can be experienced through a great number of senses, and another one contained those of a small number of sensory modalities. In addition to the traditional concreteness effect and that of the task, we observed the hypothesized effect of the number of sense modalities as well. As expected, participants were more accurate in cued recall task, more accurate when recalling concrete words, and more accurate when recalling concrete words with a large number of sensory modalities. The number of modalities effect was observed in the second experiment, where participants were presented with all three groups of words. To our best knowledge, this finding is the first demonstration of the effect of number of sensory modalities on memory processes. Finally, as expected, we observed that the concreteness effect was more pronounced in cued recall task. However, this interaction was not observed in the second experiment. Hence, we suggest further research of this phenomenon. [ABSTRACT FROM AUTHOR]