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Objectives: To identify and prioritize the top 10 research questions for PsA., Methods: The British Psoriatic Arthritis Consortium (BritPACT) formed a Priority Setting Partnership (PSP) comprising of people living with PsA, carers and clinicians, supported by the James Lind Alliance (JLA). This PSP followed the established three-stage JLA process: first, an online survey of people living with PsA, carers and clinicians to identify PsA questions, asking, 'What do you think are the most important unanswered questions in psoriatic arthritis research?' The questions were checked against existing evidence to establish 'true uncertainties' and grouped as 'indicative questions' reflecting the overarching themes. Then a second online survey ranked the 'true uncertainties' by importance. Finally, a workshop including people living with PsA and clinician stakeholders finalized the top 10 research priorities., Results: The initial survey attracted 317 respondents (69% people living with PsA, 15% carers), with 988 questions. This generated 46 indicative questions. In the second survey, 422 respondents (78% people living with PsA, 4% carers) prioritized these. Eighteen questions were taken forward to the final online workshop. The top unanswered PsA research question was 'What is the best strategy for managing patients with psoriatic arthritis including non-drug and drug treatments?' Other top 10 priorities covered diagnosis, prognosis, outcome assessment, flares, comorbidities and other aspects of treatment (https://www.jla.nihr.ac.uk)., Conclusion: The top 10 priorities will guide PsA research and enable PsA researchers and those who fund research to know the most important questions for people living with PsA., (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.)

Outdoor Learning in natural environments is a burgeoning approach in the educational sector. However, the evidence-base of research has not kept pace with teacher perceptions and increased practitioner usage. Anecdotal evidence and formal research suggest the significant health and wellbeing benefits of nature connection. Offering low-cost, non-invasive pedagogical solutions to public health challenges-particularly around mental health, wellbeing, physical literacy, and increasing physical activity-the pedagogical benefits of Outdoor Learning are yet to be fully enunciated. The proposed systematic review will search for studies across eight academic databases which measure the academic and socio-emotional benefits of Outdoor Learning, with a focus on school-aged educational settings. Using the inclusion criteria set out in this paper (and registered with PROSPERO: CRD42020153171), relevant studies will be identified then summarised to provide a synthesis of the current literature on Outdoor Learning. The goal of this review is to document the widespread international investigation into Outdoor Learning and its associated benefits for development, wellbeing, and personal growth. The systematic review will provide insights for teacher-training institutions, educational policy makers, and frontline teachers to improve the learning experiences of future students.

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Physical activity (PA) has been shown to be related to physical and mental health. Yet there are few studies on how the frequency of PA relates to health and a healthy lifestyle. We aimed to investigate how the frequency of different PAs is associated with the following health indicators: body mass index (BMI), substance consumption, physical health, and mental health. We focused on three types of PA: (1) medium- to high-intensity aerobic exercise; (2) low- to medium-intensity relaxing exercise; and (3) outdoor leisure PA. A total of 9617 volunteers, aged 19 to 81, participated in the study. The relationships between the frequencies of the three types of PA and health-related and sociodemographic factors were analyzed using multinomial logistic regression. We found that women more frequently engaged in PA type 2, and men in types 1 and 3. A higher frequency of PA was associated with lower BMI and less or no smoking behavior; higher education (PAs 1 and 3); higher age (PAs 2 and 3); better physical health (PAs 1 and 3); and better mental health (PA 3). In conclusion, higher frequency of different PAs was significantly associated with better physical and mental health, less smoking, higher age, and a higher level of education. [ABSTRACT FROM AUTHOR]

Copyright of Didáctica de las Ciencias Experimentales y Sociales is the property of Didactica de las Ciencias Experimentales y Sociales and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Community Service & Empowerment is the property of Journal of Community Service & Empowerment and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The implementation of environmental education in the world is affected by the COVID-19 pandemic, so researchers must be responsive, adjust and creative strategies to survive, and think about future anticipations. The focus and concern of researchers towards the theme of environmental education and COVID-19 is highly expected, as evidenced by the research results published in reputable journals. The purpose of this systematic literature review was to review and compare investigations of research on articles published by Scopus indexed journals. We used the phrase "environmental education and COVID-19" in the disbursement menu in Scopus Database and found 1379 articles. Furthermore, only 21 articles met the criteria to be analyzed. The inclusion and exclusion model used is PRISMA. There has been a trend of increasing publications in the last four years. Environmental education issues can be approached through qualitative, quantitative, mix-method, case studies, and R&D. The authors most in the spotlight are Lowan-Trudeau, G. (reference), Aristovnik, A. (bibliographic coupling), and Mehmood, R. (co-citation). The keywords that are mostly used by the author are COVID-19, education, higher education, and sustainable development. This environmental education keyword has branches into climate change, sustainable development, and adaptation. There are 22 countries of origin of authors who published articles, dominantly from the United States and the Republic of Korea. Articles are published equally by authors from Europe, Asia, and America. It was found that there were more articles published in collaboration between universities within one country and between countries. Rarely are articles written by a single author. There are 20 institutions that provide funding for research and publications. Most publications have fulfilled one of the ethics by declaring funding status. We succeeded in formulating and discussing a description of the existence of environmental education during the COVID-19 pandemic. These findings can serve as a consideration or baseline for researchers to study environmental education and COVID-19 themes according to their respective backgrounds and objectives. [ABSTRACT FROM AUTHOR]

Outdoor and nature-based activities promote better health and academic outcomes for children. The school context represents a critical opportunity to support increased outdoor time. Yet, outdoor learning (OL) is not being implemented consistently across school contexts, therefore, many students do not receive the opportunity to participate. This study was designed to support increased uptake of OL and explores young children's perspectives of learning within an outdoor context and explores how educators support OL opportunities within an early learning context. This research places a focus on children's voices in order to emphasize their perspective of the learning experience and to highlight experiential child-led processes within OL. We collected semistructured interviews with students, their parents and school staff who were involved in OL. An exploratory thematic analysis was applied using QSR NVivo. Findings that emerged were organized under two main themes: Nature as the teacher and Child-led exploration of nature. Nature as a teacher contained three subthemes: 1) Seasonal change influencing inquiry, 2) Engagement with other living things in nature and 3) Dimensionality of the outdoors as an element that enhances learning - experiential immersive learning. Child-led exploration of nature contained one subtheme: Learning driven by play. These findings can be used to advocate for increased uptake of OL in education and to provide guidance to educators regarding how to include OL within their practice to enhance equitable access for children. [ABSTRACT FROM AUTHOR]

Salt harvesting through natural solar evaporation of salt brines is a practice notably abundant in the Iberian Peninsula. Such activity has been relevant for human consumption, food preservation, livestock feed, and various industries throughout history. The objective of this research is to analyze the productive history and conservation state of the salt evaporation ponds located in Naval and Peralta de la Sal (Huesca, Spain), as well as their didactic potential. These saltworks are associated with clay and gypsum levels from the Upper Triassic (Keuper). The earliest written records of salt production in the area date back to the 10th century, but they were exploited as early as the Bronze Age. Remains of most of the ponds and some buildings are still preserved and are easily accessed, which makes them very interesting from an educational perspective. Both on-site and off-site activities can be carried out to analyze their historical and current significance through modeling and argumentation practices. This can lead to a better understanding of how geology relates to everyday life and facilitate the development of positive attitudes among students towards geoheritage while raising awareness about its preservation and preventing its degradation. [ABSTRACT FROM AUTHOR]

Objectives of the research: The aim of this study was to gather information about preschool teachers' expectations and attitudes toward outdoor education in the context of shaping and improving the quality of education. The study sought to collect material that would address the following research questions: What does outdoor education mean to preschool teachers? How do preschool teachers implement outdoor activities? What are the challenges of outdoor education according to the surveyed teachers? Research methods: The main research method used was a focus interview. A brief description of the context of the issue: Human beings are connected to nature, we are part of it, and we live and function thanks to it. From early childhood, the natural environment is the closest and most natural for humans, and thanks to our cognitive needs and childlike perceptiveness, we immerse ourselves in the world of nature spontaneously and with great interest. Preschool teachers should see meeting children's need for curiosity and discovery of new knowledge as a challenge, and prioritize activities in this area. Furthermore, the natural environment, due to its resources, can be perceived as a workshop that teaches knowledge about the world, allows for developing children's vocabulary and shaping new concepts. It also teaches humility, patience and understanding. The environment naturally enhances the activity of children who feel comfortable in nature. Research findings: The importance of outdoor education in children's development has been discussed for years. Unfortunately, as the results of the survey suggest, this does not convince teachers to move part of the educational process outdoors. Teachers list certain limitations and shortcomings as factors that prevent the implementation of this approach in Polish preschool institutions. Conclusions and recommendations: The teachers participating in the focus groups recognize that the implementation of outdoor education activities in kindergartens is necessary, if not indispensable. They see outdoor education primarily as an opportunity for experience-based learning and connecting with nature. The teachers are sufficiently motivated to offer outdoor activities so that children can play and learn simultaneously. However, many see significant obstacles in the education system when planning outdoor learning experiences for their students. To make outdoor education more sustainable and integrated into preschool practices, it would be necessary to remove these barriers and provide support at all levels of the education system and society. [ABSTRACT FROM AUTHOR]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Italian Journal of Health Education, Sport & Inclusive Didactics is the property of Edizioni Universitarie Romane and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

There is an increasing concern regarding the mental health and wellbeing of children and young people; as a result, schools are increasingly expected to provide support, but they have few resources to do so. As such, there is a need for establishing mechanisms for supporting the health and wellbeing of children and young people that are relatively easy and cost-effective and that can be embedded within the school day to ensure sustainability. The overarching aim of our Branching Out project was to understand how successful elements from one such programme that supports children's mental health through the art-in-nature-based practice can be expanded from school-based approaches that reach small numbers of children to include whole communities. This paper reports on one strand that examined the practice of organisations offering arts and/or nature-based activities outdoors in schools, either as part of the curriculum or as an extra-curricular activity. Survey questions served as an a priori thematic framework around the characteristics of arts-in-nature activities delivered; the perceived impacts of activities; working with volunteers, teachers, and schools; and barriers to expansion and sustainability. Despite extensive searching, identifying, and recruiting relevant arts organisations was difficult; however, respondents strongly supported the notion that the arts-in-nature practice has a positive impact on children and young people's connection to nature, supports their mental health and wellbeing, and engages them with their local environment. Yet, challenges were identified in engaging teachers and schools and funding such projects, suggesting a need for a multi-professional approach to creating more sustainable and impactful practice for children, young people, and communities. [ABSTRACT FROM AUTHOR]

Copyright of Lumat is the property of University of Helsinki and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Despite the recognized benefits of physical activity on health, most youth, especially those with a migrant background, do not meet movement guidelines. Outdoor learning is recognized as a promising intervention to address this issue. The objective of this quasi-experimental study was to measure the effects of the PASE ("Outdoors, Health and Environment") outdoor learning program on the physical activity of students with a migrant background compared to a control group with similar sociocultural characteristics. Methods: In October 2019, 91 participants from six elementary grade 6 classes (47.3% female, age 11.61 ± 0.41) wore a validated accelerometer for 7 consecutive days. Three comparative analyses were performed: full week, school day, and activity domains. The Mann-Whitney U test for independent samples was used to compare the differences in means and Cohen's d was calculated to obtain their effect sizes. Results: Analysis of the full week revealed no significant differences between groups. Analysis of school days without physical education classes showed that girls exposed to PASE spent a greater percentage of their time in MVPA than those in the control group (+4.30%, 95% CI = 1.93 to 6.68; p < 0.01) with a strong effect size (d = 1.14). In the activity domain analysis, more time in MVPA was spent in PASE outdoor learning than in the regular classroom (+11.15%, 95% CI = 9.70 to 12.61; p < 0.01) with a strong effect size (d = 3.63). Conclusion: Outdoor learning has positive effects on the physical activity of students with a migrant background during school hours. Further studies are needed to confirm these observations. [ABSTRACT FROM AUTHOR]

Helminth infections caused by Enterobius vermicularis have a cosmopolitan character and most often affect the paediatric pre-school and school age population. The presented study was conducted to determine the prevalence of E. vermicularis in the analyzed population of children in the Eastern Slovakia. The Graham's scotch tape method was used to investigate the presence of Enterobius vermicularis eggs in 390 specimens. The analyzed set consisted of 218 girls and 172 boys, divided by age into three groups - aged from 5 months to 2 years, aged from 3 to 6 years, and aged from 7 to 15 years. Investigation of perianal scotch tapes of children for the presence of E. vermicularis eggs revealed the prevalence of E. vermicularis was P = 3.59 %. Depending on the incidence of E. vermicularis infection, we detected no statistically signifi cant difference (p> 0.05). The prevalence of E. vermicularis in boys was P = 4.07 %, and in girls P = 3.21 %. The highest prevalence of E. vermicularis was recorded in the group of children aged from 3 to 6 years (P = 5.03 %). Most of the samples were positive at age 4 and 5. The lowest prevalence was in the group of children aged from 5 months to 2 years (P = 0.97 %), and the prevalence of E. vermicularis in the group of children aged from 7 to 15 was P = 3.91 %. The difference in the incidence of E. vermicularis infection among different age groups of children was not statistically significant (p> 0.05). Enterobius vermicularis nematode infection and enterobiasis currently represents a major public health problem in Slovakia. At the present its occurrence is the most frequent in the paediatric population. Therefore it is important to introduce a targeted hygienic-epidemiological measure in children's collectives, what also should include proper and effective diagnostics and frequent recurrent therapy. [ABSTRACT FROM AUTHOR]

Peptide thioesters are very useful in protein chemistry, and chemistry- and biochemistry-based protocols are used for the preparation of thioesters. Among such protocols, only a few biochemistry-based approaches have been use for naturally occurring peptide sequences. The development of chemistry-based protocols applicable to natural sequences remains a challenge, and the development of such methods would be a major contribution to protein science. Here, we describe the preparation of peptide thioesters using innovative methodology that features nickel(II)-mediated alcoholysis of a naturally occurring peptide sequence, followed by O−N and N−S acyl transfers. This protocol involves sequential quadruple acyl transfer, termed SQAT. Notably, the SQAT system consists of sequential chemical reactions that allow naturally occurring peptide sequences to be converted to thioesters without requiring an artificial chemical unit. [ABSTRACT FROM AUTHOR]

miRNAs are short, non-coding, regulatory RNAs that exert cell type-dependent, context-dependent, transcriptome-wide gene expression control under physiological and pathological conditions. Tissue slide-based assays provide qualitative (tumor compartment) and semi-quantitative (expression levels) information about altered miRNA expression at single-cell resolution in clinical tumor specimens. Reviewed here are key technological advances in the last 5 years that have led to implementation of fully automated, robust and reproducible tissue slide-based assays for in situ miRNA detection on US FDA-approved instruments; recent tissue slide-based discovery studies that suggest potential clinical applications of specific miRNAs in cancer medicine are highlighted; and the challenges in bringing tissue slide-based miRNA assays into the clinic are discussed, including clinical validation, biomarker performance, biomarker space and integration with other biomarkers. [ABSTRACT FROM AUTHOR]

(1) Background: The purpose of the study was to assess the impact of physical activity outdoors in nature as part of physical education in schools on the level of knowledge and ecological attitudes. (2) Material and methods: A total of 220 students took part in the study, with 103 of them in the treatment group, which usually practiced outdoor physical education classes, and 117 in the control group, which practiced mainly indoor. The project lasted 21 months, covering the last two years of primary school. The authors used the Children's Environmental Attitude and Knowledge Scale CHEAKS in this study. The authors sought for an answer to the question of whether bringing a young person closer to nature by participating in a greater number of outdoor physical education lessons results in in-depth environmental knowledge. (3) Results: The appearance of seven statistically significant differences in ecological knowledge in the final study in favor of the group having outdoor physical education lessons proves the cognitively and visually stimulating role of a natural environment for physically active people. The location of physical education lessons turned out to be a much stronger condition for in-depth knowledge than gender, place of residence, parents' education level, and subjective assessment of the financial satisfaction level. (4) Conclusion: These results are an incentive to further developing the young generation's contact with nature through outdoor physical education lessons. [ABSTRACT FROM AUTHOR]

Background. Several approaches have been proposed to pharmacologically ameliorate hepatic ischemia/reperfusion injury (IRI). This study was designed to evaluate the effects of a preconditioning oral nutritional supplement (pONS) containing glutamine, antioxidants, and green tea extract on hepatic warm IRI in pigs. Methods. pONS (70 g per serving, Fresenius Kabi, Germany) was dissolved in 250mL tap water and given to pigs 24, 12, and 2 hrs before warm ischemia of the liver. A fourth dose was given 3 hrs after reperfusion. Controls were given the same amount of cellulose with the same volume of water. Two hours after the third dose of pONS, both the portal vein and the hepatic artery were clamped for 40min. 0.5, 3, 6, and 8 hrs after reperfusion, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), portal venous flow (PVF), hepatic arterial flow (HAF), bile flow, and transaminases were measured. Liver tissue was taken 8 hrs after reperfusion for histology and immunohistochemistry. Results. HR,MAP, CVP, HAF, and PVF were comparable between the two groups. pONS significantly increased bile flow 8 hrs after reperfusion. ALT and AST were significantly lower after pONS. Histology showed significantly more severe necrosis and neutrophil infiltration in controls. pONS significantly decreased the index of immunohistochemical expression for TNF-α MPO, and cleaved caspase-3 (P < 0.001). Conclusion. Administration of pONS before and after tissue damage protects the liver from warm IRI via mechanisms including decreasing oxidative stress, lipid peroxidation, apoptosis, and necrosis. [ABSTRACT FROM AUTHOR]

Between August 2001 and July 2002, a cross-sectional survey was conducted to investigate clinical and epidemiological data on pinworm infection among 427 preschool and primary school age children of six rural communities from the semiarid region of Falcon state, northwestern Venezuela. Children were evaluated clinically and parasitologically by the Graham method. Overall prevalence was high (63.23 %). Pinworm infection rates were not significantly different between sex or age, suggesting similar transmission pattern and risk conditions for all individuals. Among the clinical findings and children’s habits, only perianal itching, enuresis, bruxism, and finger sucking showed significant higher percentages in infected children than in uninfected. Of interest was that anal pruritus (odds ratio [OR], 2.441), finger sucking (OR, 1.901), lower socioeconomic levels (OR, 4.358) and high levels of overcrowding conditions (≥ 3 persons/room: OR, 1.878; ≥ 2 persons/bed: OR, 11.833) appeared to be significant factors associated with transmission and endemic maintenance of enterobiasis among student children in this semi-arid Venezuelan region. [ABSTRACT FROM AUTHOR]

The objective of the present review is to examine critically the consequences of interactions that micronutrients undergo with nutrients and non-nutrients (mainly prescribed medicines) in diets and lifestyle factors (smoking, tea and alcohol consumption). In addition, the review describes recent work on interactions between nutrients and genes, the influence of gene polymorphisms on micronutrients, the impact of immune responses on micronutrients and specific interactions of antioxidant micronutrients in disease processes to minimise potential pro-oxidant damage. [ABSTRACT FROM AUTHOR]