23 results on '"Covello, Remo Daniel"'
Search Results
2. Does melatonin reduce mortality in COVID-19?
- Author
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Pilia, Eros, primary, Alborino, Ettore, additional, and Covello, Remo Daniel, additional
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- 2022
- Full Text
- View/download PDF
3. Noninvasive Ventilatory Support of COVID-19 Patients Outside the Intensive Care Units (WARd-COVID)
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Bellani, G, Grasselli, G, Cecconi, M, Antolini, L, Borelli, M, De Giacomi, F, Bosio, G, Latronico, N, Filippini, M, Gemma, M, Giannotti, C, Antonini, B, Petrucci, N, Zerbi, S, Maniglia, P, Castelli, G, Marino, G, Subert, M, Citerio, G, Radrizzani, D, Mediani, T, Lorini, F, Russo, F, Faletti, A, Beindorf, A, Covello, R, Greco, S, Bizzarri, M, Ristagno, G, Mojoli, F, Pradella, A, Severgnini, P, Da Macallè, M, Albertin, A, Ranieri, V, Rezoagli, E, Vitale, G, Magliocca, A, Cappelleri, G, Docci, M, Aliberti, S, Serra, F, Rossi, E, Valsecchi, M, Pesenti, A, Foti, G, Bellani, Giacomo, Grasselli, Giacomo, Cecconi, Maurizio, Antolini, Laura, Borelli, Massimo, De Giacomi, Federica, Bosio, Giancarlo, Latronico, Nicola, Filippini, Matteo, Gemma, Marco, Giannotti, Claudia, Antonini, Benvenuto, Petrucci, Nicola, Zerbi, Simone Maria, Maniglia, Paolo, Castelli, Gian Paolo, Marino, Giovanni, Subert, Matteo, Citerio, Giuseppe, Radrizzani, Danilo, Mediani, Teresa S, Lorini, Ferdinando Luca, Russo, Filippo Maria, Faletti, Angela, Beindorf, Andrea, Covello, Remo Daniel, Greco, Stefano, Bizzarri, Marta M, Ristagno, Giuseppe, Mojoli, Francesco, Pradella, Andrea, Severgnini, Paolo, Da Macallè, Marta, Albertin, Andrea, Ranieri, V Marco, Rezoagli, Emanuele, Vitale, Giovanni, Magliocca, Aurora, Cappelleri, Gianluca, Docci, Mattia, Aliberti, Stefano, Serra, Filippo, Rossi, Emanuela, Valsecchi, Maria Grazia, Pesenti, Antonio, Foti, Giuseppe, Bellani, G, Grasselli, G, Cecconi, M, Antolini, L, Borelli, M, De Giacomi, F, Bosio, G, Latronico, N, Filippini, M, Gemma, M, Giannotti, C, Antonini, B, Petrucci, N, Zerbi, S, Maniglia, P, Castelli, G, Marino, G, Subert, M, Citerio, G, Radrizzani, D, Mediani, T, Lorini, F, Russo, F, Faletti, A, Beindorf, A, Covello, R, Greco, S, Bizzarri, M, Ristagno, G, Mojoli, F, Pradella, A, Severgnini, P, Da Macallè, M, Albertin, A, Ranieri, V, Rezoagli, E, Vitale, G, Magliocca, A, Cappelleri, G, Docci, M, Aliberti, S, Serra, F, Rossi, E, Valsecchi, M, Pesenti, A, Foti, G, Bellani, Giacomo, Grasselli, Giacomo, Cecconi, Maurizio, Antolini, Laura, Borelli, Massimo, De Giacomi, Federica, Bosio, Giancarlo, Latronico, Nicola, Filippini, Matteo, Gemma, Marco, Giannotti, Claudia, Antonini, Benvenuto, Petrucci, Nicola, Zerbi, Simone Maria, Maniglia, Paolo, Castelli, Gian Paolo, Marino, Giovanni, Subert, Matteo, Citerio, Giuseppe, Radrizzani, Danilo, Mediani, Teresa S, Lorini, Ferdinando Luca, Russo, Filippo Maria, Faletti, Angela, Beindorf, Andrea, Covello, Remo Daniel, Greco, Stefano, Bizzarri, Marta M, Ristagno, Giuseppe, Mojoli, Francesco, Pradella, Andrea, Severgnini, Paolo, Da Macallè, Marta, Albertin, Andrea, Ranieri, V Marco, Rezoagli, Emanuele, Vitale, Giovanni, Magliocca, Aurora, Cappelleri, Gianluca, Docci, Mattia, Aliberti, Stefano, Serra, Filippo, Rossi, Emanuela, Valsecchi, Maria Grazia, Pesenti, Antonio, and Foti, Giuseppe
- Abstract
Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use of NIV in COVID-19 is limited. Objectives: To describe the prevalence and clinical characteristics of patientswith COVID-19 treated with NIVoutside the ICUs. To investigate the factors associated with NIV failure (need for intubation or death). Methods: In this prospective, single-day observational study, we enrolled adult patients with COVID-19 who were treated with NIV outside the ICU from 31 hospitals in Lombardy, Italy. Results: We collected data on demographic and clinical characteristics, ventilatorymanagement, and patient outcomes.Of 8,753 patients with COVID-19 present in the hospitals on the study day, 909 (10%) were receiving NIV outside the ICU. A majority of patients (778/909; 85%) patients were treated with continuous positive airway pressure (CPAP), which was delivered by helmet in 617 (68%) patients. NIV failed in 300 patients (37.6%), whereas 498 (62.4%) patients were discharged alive without intubation. Overall mortality was 25%. NIV failure occurred in 152/284 (53%) patients with an arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FIO2) ratio ,150 mm Hg. Higher C-reactive protein and lower PaO2/FIO2 and platelet counts were independently associated with increased risk of NIV failure. Conclusions: The use of NIV outside the ICUs was common in COVID-19, with a predominant use of helmet CPAP, with a rate of success.60% and close to 75% in full-treatment patients. C-reactive protein, PaO2/FIO2, and platelet counts were independently associated with increased risk of NIV failure.
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- 2021
4. Different impact of sex on baseline characteristics and major periprocedural outcomes of transcatheter and surgical aortic valve interventions: Results of the multicenter Italian OBSERVANT Registry
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Onorati, Francesco, D’Errigo, Paola, Barbanti, Marco, Rosato, Stefano, Covello, Remo Daniel, Maraschini, Alice, Ranucci, Marco, Santoro, Gennaro, Tamburino, Corrado, Grossi, Claudio, Santini, Francesco, Menicanti, Lorenzo, and Seccareccia, Fulvia
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- 2014
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5. Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy
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Grasselli, Giacomo, Greco, Massimiliano, Zanella, Alberto, Albano, Giovanni, Antonelli, Massimo, Bellani, Giacomo, Bonanomi, Ezio, Cabrini, Luca, Carlesso, Eleonora, Castelli, Gianpaolo, Cattaneo, Sergio, Cereda, Danilo, Colombo, Sergio, Coluccello, Antonio, Crescini, Giuseppe, Forastieri Molinari, Andrea, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio Antonio, Langer, Thomas, Latronico, Nicola, Lorini, Ferdinando Luca, Mojoli, Francesco, Natalini, Giuseppe, Pessina, Carla Maria, Ranieri, Vito Marco, Rech, Roberto, Scudeller, Luigia, Rosano, Antonio, Storti, Enrico, Thompson, B. Taylor, Tirani, Marcello, Villani, Pier Giorgio, Pesenti, Antonio, Cecconi, Maurizio, Agosteo, Emiliano, Albertin, Andrea, Alborghetti, Armando, Aldegheri, Giorgio, Antonini, Benvenuto, Barbara, Enrico, Bardelloni, Giulia, Basilico, Sabrina, Belgiorno, Nicolangela, Beretta, Enrico, Berselli, Angela, Bianciardi, Leonardo, Bonazzi, Stefano, Borelli, Massimo, Bottino, Nicola, Bronzini, Nicola, Brusatori, Serena, Capra, Carlo, Carnevale, Livio, Catena, Emanuele, Celotti, Simona, Cerutti, Stefania, Chiumello, Davide, Cirri, Silvia, Citerio, Giuseppe, Coppini, Davide, Corona, Alberto, Cortellazzi, Paolo, Costantini, Elena, Covello, Remo Daniel, De Filippi, Gianluca, Dei Poli, Marco, Dughi, Paolo, Fieni, Fulvia, Florio, Gaetano, Galletti, Marco, Gallioli, Giorgio Antonio, Gay, Hedwige, Gemma, Marco, Gnesin, Paolo, Greco, Stefano, Grosso, Paolo, Guatteri, Luca, Guzzon, Davide, Keim, Roberto, Lombardo, Andrea, Mamprin, Filippo, Marino, Giovanni, Marino, Francesco, Merli, Guido, Micucci, Antonio, Militano, Carmine Rocco, Monti, Giacomo, Muttini, Stefano, Nadalin, Samantha, Perazzo, Paolo, Perego, Giovanni Battista, Perotti, Luciano, Petrucci, Nicola, Pezzi, Angelo, Piva, Simone, Portella, Gina, Protti, Alessandro, Racagni, Milena, Radrizzani, Danilo, Raimondi, Maurizio, Ranucci, Marco, Riccio, Mario, Ruggeri, Patrizia, Sala, Giuseppe, Salvi, Luca, Sebastiano, Pietro, Severgnini, Paolo, Sigurtà, Donato, Stocchetti, Nino, Subert, Matteo, Tavola, Mario, Todaro, Serena, Torriglia, Francesca, Tubiolo, Daniela, Valsecchi, Roberto, Viola, Uberto, Vitale, Giovanni, Zambon, Massimo, Zoia, Elena, Grasselli, G, Greco, M, Zanella, A, Albano, G, Antonelli, M, Bellani, G, Bonanomi, E, Cabrini, L, Carlesso, E, Castelli, G, Cattaneo, S, Cereda, D, Colombo, S, Coluccello, A, Crescini, G, Forastieri Molinari, A, Foti, G, Fumagalli, R, Iotti, G, Langer, T, Latronico, N, Lorini, F, Mojoli, F, Natalini, G, Pessina, C, Ranieri, V, Rech, R, Scudeller, L, Rosano, A, Storti, E, Thompson, B, Tirani, M, Villani, P, Pesenti, A, Cecconi, M, Grasselli G., Greco M., Zanella A., Albano G., Antonelli M., Bellani G., Bonanomi E., Cabrini L., Carlesso E., Castelli G., Cattaneo S., Cereda D., Colombo S., Coluccello A., Crescini G., Forastieri Molinari A., Foti G., Fumagalli R., Iotti G.A., Langer T., Latronico N., Lorini F.L., Mojoli F., Natalini G., Pessina C.M., Ranieri V.M., Rech R., Scudeller L., Rosano A., Storti E., Thompson B.T., Tirani M., Villani P.G., Pesenti A., and Cecconi M.
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medicine.medical_specialty ,COVID19 ,mechanical ventilation ,01 natural sciences ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,COVID-19, ICU, critical illness, mechanical ventilation, mortality ,Interquartile range ,law ,Intensive care ,Internal medicine ,Internal Medicine ,critical illness ,Medicine ,030212 general & internal medicine ,0101 mathematics ,Risk factor ,business.industry ,Mortality rate ,010102 general mathematics ,Hazard ratio ,COVID-19 ,Retrospective cohort study ,mortality ,Intensive care unit ,ICU ,na ,business ,Cohort study - Abstract
Importance Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive care unit (ICU). Objective To evaluate the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. Design, Setting, and Participants This retrospective, observational cohort study included 3988 consecutive critically ill patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinating center (Fondazione IRCCS [Istituto di Ricovero e Cura a Carattere Scientifico] Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network from February 20 to April 22, 2020. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by real-time reverse transcriptase–polymerase chain reaction assay of nasopharyngeal swabs. Follow-up was completed on May 30, 2020. Exposures Baseline characteristics, comorbidities, long-term medications, and ventilatory support at ICU admission. Main Outcomes and Measures Time to death in days from ICU admission to hospital discharge. The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional hazards regression. Results Of the 3988 patients included in this cohort study, the median age was 63 (interquartile range [IQR] 56-69) years; 3188 (79.9%; 95% CI, 78.7%-81.1%) were men, and 1998 of 3300 (60.5%; 95% CI, 58.9%-62.2%) had at least 1 comorbidity. At ICU admission, 2929 patients (87.3%; 95% CI, 86.1%-88.4%) required invasive mechanical ventilation (IMV). The median follow-up was 44 (95% CI, 40-47; IQR, 11-69; range, 0-100) days; median time from symptoms onset to ICU admission was 10 (95% CI, 9-10; IQR, 6-14) days; median length of ICU stay was 12 (95% CI, 12-13; IQR, 6-21) days; and median length of IMV was 10 (95% CI, 10-11; IQR, 6-17) days. Cumulative observation time was 164 305 patient-days. Hospital and ICU mortality rates were 12 (95% CI, 11-12) and 27 (95% CI, 26-29) per 1000 patients-days, respectively. In the subgroup of the first 1715 patients, as of May 30, 2020, 865 (50.4%) had been discharged from the ICU, 836 (48.7%) had died in the ICU, and 14 (0.8%) were still in the ICU; overall, 915 patients (53.4%) died in the hospital. Independent risk factors associated with mortality included older age (hazard ratio [HR], 1.75; 95% CI, 1.60-1.92), male sex (HR, 1.57; 95% CI, 1.31-1.88), high fraction of inspired oxygen (Fio2) (HR, 1.14; 95% CI, 1.10-1.19), high positive end-expiratory pressure (HR, 1.04; 95% CI, 1.01-1.06) or low Pao2:Fio2ratio (HR, 0.80; 95% CI, 0.74-0.87) on ICU admission, and history of chronic obstructive pulmonary disease (HR, 1.68; 95% CI, 1.28-2.19), hypercholesterolemia (HR, 1.25; 95% CI, 1.02-1.52), and type 2 diabetes (HR, 1.18; 95% CI, 1.01-1.39). No medication was independently associated with mortality (angiotensin-converting enzyme inhibitors HR, 1.17; 95% CI, 0.97-1.42; angiotensin receptor blockers HR, 1.05; 95% CI, 0.85-1.29). Conclusions and Relevance In this retrospective cohort study of critically ill patients admitted to ICUs in Lombardy, Italy, with laboratory-confirmed COVID-19, most patients required IMV. The mortality rate and absolute mortality were high.
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- 2020
6. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy
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Grasselli, Giacomo, Zangrillo, Alberto, Zanella, Alberto, Antonelli, Massimo, Cabrini, Luca, Castelli, Antonio, Cereda, Danilo, Coluccello, Antonio, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio, Latronico, Nicola, Lorini, Luca, Merler, Stefano, Natalini, Giuseppe, Piatti, Alessandra, Ranieri, Marco Vito, Scandroglio, Anna Mara, Storti, Enrico, Cecconi, Maurizio, Pesenti, Antonio, Agosteo, Emiliano, Alaimo, Valentina, Albano, Giovanni, Albertin, Andrea, Alborghetti, Armando, Aldegheri, Giorgio, Antonini, Benvenuto, Barbara, Enrico, Belgiorno, Nicolangela, Belliato, Mirko, Benini, Annalisa, Beretta, Enrico, Bianciardi, Leonardo, Bonazzi, Stefano, Borelli, Massimo, Boselli, Enrico, Bronzini, Nicola, Capra, Carlo, Carnevale, Livio, Casella, Giampaolo, Castelli, Gianpaolo, Catena, Emanuele, Cattaneo, Sergio, Chiumello, Davide, Cirri, Silvia, Citerio, Giuseppe, Colombo, Sergio, Coppini, Davide, Corona, Alberto, Cortellazzi, Paolo, Costantini, Elena, Covello, Remo Daniel, De Filippi, Gianluca, Dei Poli, Marco, Della Mura, Federica, Evasi, Giulia, Fernandez-Olmos, Raquel, Forastieri Molinari, Andrea, Galletti, Marco, Gallioli, Giorgio, Gemma, Marco, Gnesin, Paolo, Grazioli, Lorenzo, Greco, Stefano, Gritti, Paolo, Grosso, Paolo, Guatteri, Luca, Guzzon, Davide, Harizay, Fabiola, Keim, Roberto, Landoni, Giovanni, Langer, Thomas, Lombardo, Andrea, Malara, Annalisa, Malpetti, Elena, Marino, Francesco, Marino, Giovanni, Mazzoni, Maurizio Giovanni, Merli, Guido, Micucci, Antonio, Mojoli, Francesco, Muttini, Stefano, Nailescu, Adriana, Panigada, Mauro, Perazzo, Paolo, Perego, Giovanni Battista, Petrucci, Nicola, Pezzi, Angelo, Protti, Alessandro, Radrizzani, Danilo, Raimondi, Maurizio, Ranucci, Marco, Rasulo, Frank, Riccio, Mario, Rona, Roberto, Roscitano, Claudio, Ruggeri, Patrizia, Sala, Antonello, Sala, Giuseppe, Salvi, Luca, Sebastiano, Pietro, Severgnini, Paolo, Sforzini, Ilaria, Sigurtà, Francesco Donato, Subert, Matteo, Tagliabue, Paola, Troiano, Carmine, Valsecchi, Roberto, Viola, Uberto, Vitale, Giovanni, Zambon, Massimo, Zoia, Elena, Grasselli, G, Zangrillo, A, Zanella, A, Antonelli, M, Cabrini, L, Castelli, A, Cereda, D, Coluccello, A, Foti, G, Fumagalli, R, Iotti, G, Latronico, N, Lorini, L, Merler, S, Natalini, G, Piatti, A, Ranieri, Mv, Scandroglio, Am, Storti, E, Cecconi, M, Pesenti, A (COVID-19 Lombardy ICU Network), Landoni, G, Ranieri, M, Scandroglio, A, Pesenti, A, and Lorini, F
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Artificial ventilation ,medicine.medical_specialty ,medicine.medical_treatment ,01 natural sciences ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Intensive care ,Internal medicine ,Settore MED/41 - ANESTESIOLOGIA ,Medicine ,030212 general & internal medicine ,0101 mathematics ,Positive end-expiratory pressure ,Original Investigation ,Mechanical ventilation ,SARS-CoV-2 ,business.industry ,010102 general mathematics ,Retrospective cohort study ,General Medicine ,medicine.disease ,Comorbidity ,Intensive care unit ,Respiratory failure ,SARS-CoV-2, ICU ,business - Abstract
Question What are the baseline characteristics and outcomes of patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection admitted to intensive care units (ICUs) in Lombardy, Italy? Findings In this retrospective case series that involved 1591 critically ill patients admitted from February 20 to March 18, 2020, 99% (1287 of 1300 patients) required respiratory support, including endotracheal intubation in 88% and noninvasive ventilation in 11%; ICU mortality was 26%. Meaning In this case series of critically ill patients admitted to ICUs in Lombardy, Italy, with laboratory-confirmed coronavirus disease 2019 (COVID-19), a high proportion required mechanical ventilation and ICU mortality was 26% as of March 25, 2020.Importance In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited. Objective To characterize patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy. Design, Setting, and Participants Retrospective case series of 1591 consecutive patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinator center (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network and treated at one of the ICUs of the 72 hospitals in this network between February 20 and March 18, 2020. Date of final follow-up was March 25, 2020. Exposures SARS-CoV-2 infection confirmed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. Main Outcomes and Measures Demographic and clinical data were collected, including data on clinical management, respiratory failure, and patient mortality. Data were recorded by the coordinator center on an electronic worksheet during telephone calls by the staff of the COVID-19 Lombardy ICU Network. Results Of the 1591 patients included in the study, the median (IQR) age was 63 (56-70) years and 1304 (82%) were male. Of the 1043 patients with available data, 709 (68%) had at least 1 comorbidity and 509 (49%) had hypertension. Among 1300 patients with available respiratory support data, 1287 (99% [95% CI, 98%-99%]) needed respiratory support, including 1150 (88% [95% CI, 87%-90%]) who received mechanical ventilation and 137 (11% [95% CI, 9%-12%]) who received noninvasive ventilation. The median positive end-expiratory pressure (PEEP) was 14 (IQR, 12-16) cm H2O, and Fio(2) was greater than 50% in 89% of patients. The median Pao(2)/Fio(2) was 160 (IQR, 114-220). The median PEEP level was not different between younger patients (n = 503 aged = 64 years) (14 [IQR, 12-15] vs 14 [IQR, 12-16] cm H2O, respectively; median difference, 0 [95% CI, 0-0]; P = .94). Median Fio(2) was lower in younger patients: 60% (IQR, 50%-80%) vs 70% (IQR, 50%-80%) (median difference, -10% [95% CI, -14% to 6%]; P = .006), and median Pao(2)/Fio(2) was higher in younger patients: 163.5 (IQR, 120-230) vs 156 (IQR, 110-205) (median difference, 7 [95% CI, -8 to 22]; P = .02). Patients with hypertension (n = 509) were older than those without hypertension (n = 526) (median [IQR] age, 66 years [60-72] vs 62 years [54-68]; P < .001) and had lower Pao(2)/Fio(2) (median [IQR], 146 [105-214] vs 173 [120-222]; median difference, -27 [95% CI, -42 to -12]; P = .005). Among the 1581 patients with ICU disposition data available as of March 25, 2020, 920 patients (58% [95% CI, 56%-61%]) were still in the ICU, 256 (16% [95% CI, 14%-18%]) were discharged from the ICU, and 405 (26% [95% CI, 23%-28%]) had died in the ICU. Older patients (n = 786; age >= 64 years) had higher mortality than younger patients (n = 795; age
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- 2020
7. Reply: TAVI in Lower Risk Patients: Revolution or Nonsense? Keep Calm and Select Patients
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Barbanti, Marco, Tamburino, Corrado, D'Errigo, Paola, Ranucci, Marco, Onorati, Francesco, Covello, Remo Daniel, Santini, Francesco, Rosato, Stefano, Santoro, Gennaro, Fusco, Danilo, Grossi, Claudio, and Seccareccia, Fulvia
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Male ,Transcatheter Aortic Valve Replacement ,Aortic Valve Stenosis ,Female ,Humans ,Cardiology and Cardiovascular Medicine - Published
- 2016
8. Tardive Coronary Obstruction By a Native Leaflet After Transcatheter Aortic Valve Replacement in a Patient With Heavily Calcified Aortic Valve Stenosis
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Giustino, Gennaro, Montorfano, Matteo, Chieffo, Alaide, Panoulas, Vasileios, Spagnolo, Pietro, Latib, Azeem, Covello, Remo Daniel, Alfieri, Ottavio, and Colombo, Antonio
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- 2014
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9. Transcatheter Aortic Valve Implantation Compared With Surgical Aortic Valve Replacement in Low-Risk Patients
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Rosato, Stefano, primary, Santini, Francesco, additional, Barbanti, Marco, additional, Biancari, Fausto, additional, D’Errigo, Paola, additional, Onorati, Francesco, additional, Tamburino, Corrado, additional, Ranucci, Marco, additional, Covello, Remo Daniel, additional, Santoro, Gennaro, additional, Grossi, Claudio, additional, Ventura, Martina, additional, Fusco, Danilo, additional, and Seccareccia, Fulvia, additional
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- 2016
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10. Reply
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Barbanti, Marco, primary, Tamburino, Corrado, additional, D’Errigo, Paola, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Santini, Francesco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, Fusco, Danilo, additional, Grossi, Claudio, additional, and Seccareccia, Fulvia, additional
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- 2016
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11. 1-Year Outcomes After Transfemoral Transcatheter or Surgical Aortic Valve Replacement
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Tamburino, Corrado, primary, Barbanti, Marco, additional, D’Errigo, Paola, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Santini, Francesco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, Fusco, Danilo, additional, Grossi, Claudio, additional, and Seccareccia, Fulvia, additional
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- 2015
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12. Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis Patients Undergoing Chronic Dialysis
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Ohno, Yohei, primary, Attizzani, Guilherme F., additional, Barbanti, Marco, additional, D’Errigo, Paola, additional, Grossi, Claudio, additional, Covello, Remo Daniel, additional, Onorati, Francesco, additional, Santini, Francesco, additional, Ranucci, Marco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, Fusco, Danilo, additional, Tamburino, Corrado, additional, and Seccareccia, Fulvia, additional
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- 2015
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13. CRT-800 Transfemoral Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Aortic Stenosis at Intermediate Surgical Risk: 12-month Results: from the OBSERVANT Study
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D'Errigo, Paola, primary, Seccareccia, Fulvia, additional, Tamburino, Corrado, additional, Barbanti, Marco, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Santini, Francesco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, and Grossi, Caludio, additional
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- 2015
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14. BLEEDING EVENTS AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION: USEFULNESS OF BASELINE ACTIVATED CLOTTING TIME IN GUIDING THE ANTITHROMBOTIC REGIMEN DURING TRANSCATHETER AORTIC VALVE IMPLANTATION PROCEDURES
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Bernelli, Chiara, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Carlino, Mauro, additional, Figini, Filippo, additional, Giannini, Francesco, additional, Buchanan, Gill Louise, additional, Covello, Remo Daniel, additional, Gerli, Chiara, additional, Annalisa, Franco, additional, Agricola, Eustachio, additional, Canna, Giovanni La, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional
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- 2013
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15. Impact of Mean Platelet Volume on Combined Safety Endpoint and Vascular and Bleeding Complications following Percutaneous Transfemoral Transcatheter Aortic Valve Implantation
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Magri, Caroline J., primary, Chieffo, Alaide, additional, Durante, Alessandro, additional, Latib, Azeem, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Cioni, Michela, additional, Agricola, Eustachio, additional, Covello, Remo Daniel, additional, Gerli, Chiara, additional, Franco, Annalisa, additional, Spagnolo, Pietro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional
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- 2013
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16. VARC OUTCOMES FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION WITH BOTH EDWARDS SAPIEN™ AND MEDTRONIC COREVALVE REVALVING SYSTEM® DEVICES: RESULTS FROM THE MILAN REGISTRY
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Buchanan, Gill Louise, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Cioni, Micaela, additional, Figini, Filippo, additional, Ferrarello, Santo, additional, Covello, Remo Daniel, additional, Franco, Annalisa, additional, Gerli, Chiara, additional, Grimaldi, Antonio, additional, Canna, Giovanni La, additional, Spagnolo, Pietro, additional, Carlino, Mauro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional
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- 2012
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17. OUTCOMES FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION COMPARING EDWARDS SAPIEN™ WITH MEDTRONIC COREVALVE REVALVING SYSTEM® DEVICES: RESULTS FROM THE MILAN REGISTRY
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Buchanan, Gill Louise, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Figini, Filippo, additional, Cioni, Micaela, additional, Ferrarello, Santo, additional, Covello, Remo Daniel, additional, Franco, Annalisa, additional, Gerli, Chiara, additional, Spagnolo, Pietro, additional, Grimaldi, Antonio, additional, Canna, Giovanni La, additional, Carlino, Mauro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional
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- 2012
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18. Surgical and transcatheter aortic valve procedures. The limits of risk scores.
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Ranucci, Marco, Guarracino, Fabio, Castelvecchio, Serenella, Baldassarri, Rubia, Covello, Remo Daniel, and Landoni, Giovanni
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Transcatheter aortic valve implantation (TAVI) is an alternative to surgical aortic valve replacement in very high-risk patients with severe aortic stenosis. The present multicenter, retrospective study investigates the accuracy and calibration properties of the EuroSCORE and the age, serum creatinine, and ejection fraction (ACEF) score in selecting a population of patients to be referred to TAVI. The study includes 1053 surgical and 211 transcatheter procedures. The operative mortality rate within the surgical group was 2%. The EuroSCORE and the ACEF score had similar levels of accuracy; the ACEF score was well calibrated and the EuroSCORE overestimated the mortality risk. The observed mortality rate within the transcatheter group was 10.4%. Cut-off values corresponding to a mortality rate of 10% were 26 for the logistic EuroSCORE and 2.5 for the ACEF score: both the EuroSCORE and the ACEF score may be used to refer patients to TAVI. However, they do not consider a number of 'extreme' risk conditions that may justify a transcatheter procedure even in absence of an overall elevated risk score. These risk conditions should be included in a specific risk model for referring patients for TAVI.
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- 2010
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19. 1-Year Outcomes After Transfemoral Transcatheter or Surgical Aortic Valve Replacement Results From the Italian OBSERVANT Study
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Tamburino, Corrado, Barbanti, Marco, D'Errigo, Paola, Ranucci, Marco, Onorati, Francesco, Covello, Remo Daniel, Santini, Francesco, Rosato, Stefano, Santoro, Gennaro, Fusco, Danilo, Grossi, Claudio, and Seccareccia, Fulvia
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Aged, 80 and over ,Heart Valve Prosthesis Implantation ,Male ,Time Factors ,aortic stenosis ,intermediate risk ,Aortic Valve Stenosis ,Transcatheter Aortic Valve Replacement ,Treatment Outcome ,Italy ,transcatheter aortic valve ,80 and over ,Humans ,Female ,implantation ,Prospective Studies ,Mortality ,Aged ,Follow-Up Studies - Abstract
BackgroundThere is a paucity of prospective and controlled data on the comparative effectiveness of transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in a real-world setting.ObjectivesThis analysis aims to describe 1-year clinical outcomes of a large series of propensity-matched patients who underwent SAVR and transfemoral TAVR.MethodsThe OBSERVANT (Observational Study of Effectiveness of SAVR–TAVI Procedures for Severe Aortic Stenosis Treatment) trial is an observational prospective multicenter cohort study that enrolled patients with aortic stenosis (AS) who underwent SAVR or TAVR. The propensity score method was applied to select 2 groups with similar baseline characteristics. All outcomes were adjudicated through a linkage with administrative databases. The primary endpoints of this analysis were death from any cause and major adverse cardiac and cerebrovascular events (MACCE) at 1 year.ResultsThe unadjusted enrolled population (N = 7,618) included 5,707 SAVR patients and 1,911 TAVR patients. The matched population had a total of 1,300 patients (650 per group). The propensity score method generated a low-intermediate risk population (mean logistic EuroSCORE 1: 10.2 ± 9.2% vs. 9.5 ± 7.1%, SAVR vs. transfemoral TAVR; p = 0.104). At 1 year, the rate of death from any cause was 13.6% in the surgical group and 13.8% in the transcatheter group (hazard ratio [HR]: 0.99; 95% confidence interval [CI]: 0.72 to 1.35; p = 0.936). Similarly, there were no significant differences in the rates of MACCE, which were 17.6% in the surgical group and 18.2% in the transcatheter group (HR: 1.03; 95% CI: 0.78 to 1.36; p = 0.831). The cumulative incidence of cerebrovascular events, and rehospitalization due to cardiac reasons and acute heart failure was similar in both groups at 1 year.ConclusionsThe results suggest that SAVR and transfemoral TAVR have comparable mortality, MACCE, and rates of rehospitalization due to cardiac reasons at 1 year. These data need to be confirmed in longer term and dedicated ongoing randomized trials.
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20. Different impact of sex on baseline characteristics and major periprocedural outcomes of transcatheter and surgical aortic valve interventions: Results of the multicenter Italian OBSERVANT Registry
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Onorati, Francesco, D'Errigo, Paola, Barbanti, Marco, Rosato, Stefano, Covello, Remo Daniel, Maraschini, Alice, Ranucci, Marco, Santoro, Gennaro, Tamburino, Corrado, Grossi, Claudio, Santini, Francesco, Menicanti, Lorenzo, Seccareccia, Fulvia, Badoni, Gabriella, Fusco, Danilo, De Palma, Rossana, Scondotto, Salvatore, Orlando, Anna, Copello, Francesco, Zanier, Loris, Zocchetti, Carlo, Cecchi, Mario, Borgia, Piero, Celentano, Egidio, Mauro, Aldo, De Luca, Giovanni, Marchetta, Fausto, Antonelli, Antonello, Porcu, Rosanna, Marra, S., D'Amico, M., Gaita, F., Moretti, C., De Benedictis, M., Aranzulla, T., Pistis, G., Reale, M., Bedogni, F., Brambilla, N., Colombo, A., Chieffo, A., Ferrari, A., Inglese, L., Casilli, F., Ettori, F., Frontini, M., Antona, C., Piccaluga, E., Klugmann, S., De Marco, F., Tespili, M., Saino, A., Franceschini Grisolia, E., Isabella, G., Fraccaro, C., Proclemer, A., Bisceglia, T., Armellini, I., Vischi, M., Parodi, E., Petronio, S., Giannini, C., Pierli, C., Iadanza, A., Santoro, G., Meucci, F., Tomai, F., Ghini, A., Sardella, Gennaro, Mancone, M., Ribichini, F., Vassanelli, C., Dandale, R., Giudice, P., Vigorito, F., Bortone, A., De Luca Tupputi Schinosa, L., De Cillis, E., Indolfi, C., Spaccarotella, C., Stabile, A., Gandolfo, C., Tamburino, C., Ussia, G., Rinaldi, M., Salizzoni, S., Grossi, C., Di Gregorio, O., Scoti, P., Costa, R., Casabona, R., Del Ponte, S., Panisi, P., Spira, G., Troise, G., Messina, A., Viganò, M., Aiello, M., Alfieri, O., Denti, P., Menicanti, L., Agnelli, B., Muneretto, C., Rambaldini, M., Gamba, A., Tasca, G., Ferrazzi, P., Terzi, A., Gelpi, G., Martinelli, L., Bruschi, G., Graffigna, A. C., Mazzucco, A., Pappalardo, A., Gatti, G., Livi, U., Pompei, E., Passerone, G., Bortolotti, U., Pratali, S., Stefano, P., Blanzola, C., Glauber, M., Cerillo, A., Chiaramonti, F., Pardini, A., Fioriello, F., Torracca, L., Rescigno, G., De Paulis, R., Nardella, S., Musumeci, F., Luzi, G., Possati, G., Bonalumi, G., Covino, E., Pollari, F., Sinatra, Riccardo, Roscitano, A., Chiariello, L., Nardi, P., Lonobile, T., Baldascino, F., Di Benedetto, G., Mastrogiovanni, G., Piazza, L., Marmo, J., Vosa, C., De Amicis, V., Villani, M., Pano, M. A., Cassese, M., Antonazzo, A., Patanè, L., Gentile, M., Tribastone, S., Follis, F., Montalbano, G., Pilato, M., Stringi, V., Patanè, F., Salamone, G., Ruvolo, G., Pisano, C., Mignosa, C., Bivona, A., Cirio, E. M., Lixi, G., Onorati, F., D'Errigo, P., Barbanti, M., Rosato, S., Covello, R. D., Maraschini, A., Ranucci, M., Santoro, G., Tamburino, C., Grossi, C., Santini, F., Menicanti, L., Seccareccia, F., Badoni, G., Fusco, D., De Palma, R., Scondotto, S., Orlando, A., Copello, F., Zanier, L., Zocchetti, C., Cecchi, M., Borgia, P., Celentano, E., Mauro, A., De Luca, G., Marchetta, F., Antonelli, A., Porcu, R., Marra, S., D'Amico, M., Gaita, F., Moretti, C., De Benedictis, M., Aranzulla, T., Pistis, G., Reale, M., Bedogni, F., Brambilla, N., Colombo, A., Chieffo, A., Ferrari, A., Inglese, L., Casilli, F., Ettori, F., Frontini, M., Antona, C., Piccaluga, E., Klugmann, S., De Marco, F., Tespili, M., Saino, A., Franceschini Grisolia, E., Isabella, G., Fraccaro, C., Proclemer, A., Bisceglia, T., Armellini, I., Vischi, M., Parodi, E., Petronio, S., Giannini, C., Pierli, C., Iadanza, A., Meucci, F., Tomai, F., Ghini, A., Sardella, G., Mancone, M., Ribichini, F., Vassanelli, C., Dandale, R., Giudice, P., Vigorito, F., Bortone, A., De Luca Tupputi Schinosa, L., De Cillis, E., Indolfi, C., Spaccarotella, C., Stabile, A., Gandolfo, C., Ussia, G., Rinaldi, M., Salizzoni, S., Di Gregorio, O., Scoti, P., Costa, R., Casabona, R., Del Ponte, S., Panisi, P., Spira, G., Troise, G., Messina, A., Vigano, M., Aiello, M., Alfieri, O., Denti, P., Agnelli, B., Muneretto, C., Rambaldini, M., Gamba, A., Tasca, G., Ferrazzi, P., Terzi, A., Gelpi, G., Martinelli, L., Bruschi, G., Graffigna, A. C., Pappalardo, A., Mazzucco, A., Livi, U., Pompei, E., Passerone, G., Bortolotti, U., Pratali, S., Stefano, P., Blanzola, C., Glauber, M., Cerillo, A., Chiaramonti, F., Pardini, A., Fioriello, F., Torracca, L., Rescigno, G., De Paulis, R., Nardella, S., Musumeci, F., Luzi, G., Possati, G., Bonalumi, G., Covino, E., Pollari, F., Sinatra, R., Roscitano, A., Chiariello, L., Nardi, P., Lonobile, T., Baldascino, F., Di Benedetto, G., Mastrogiovanni, G., Piazza, L., Marmo, J., Vosa, C., De Amicis, V., Villani, M., Pano, M. A., Cassese, M., Antonazzo, A., Patane, L., Gentile, M., Tribastone, S., Montalbano, G., Follis, F., Pilato, M., Stringi, V., Patane, F., Salamone, G., Ruvolo, G., Pisano, C., Mignosa, C., Bivona, A., Cirio, E. M., and Lixi, G.
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Aortic valve ,Registrie ,Age Factors ,Aged ,Aged, 80 and over ,Aortic Valve ,Aortic Valve Stenosis ,Blood Transfusion ,Chi-Square Distribution ,Comorbidity ,Female ,Heart Valve Prosthesis Implantation ,Hospital Mortality ,Humans ,Italy ,Linear Models ,Logistic Models ,Male ,Multivariate Analysis ,Odds Ratio ,Postoperative Complications ,Prospective Studies ,Registries ,Risk Assessment ,Risk Factors ,Severity of Illness Index ,Sex Factors ,Time Factors ,Treatment Outcome ,Cardiac Catheterization ,Health Status Disparities ,Surgery ,Medicine (all) ,Pulmonary and Respiratory Medicine ,Cardiology and Cardiovascular Medicine ,medicine.medical_treatment ,Sex Factor ,Aortic valve replacement ,80 and over ,Age Factor ,Myocardial infarction ,Multivariate Analysi ,education.field_of_study ,Ejection fraction ,medicine.anatomical_structure ,Aortic valve stenosis ,Cardiology ,Linear Model ,Human ,medicine.medical_specialty ,Logistic Model ,Time Factor ,Population ,Internal medicine ,medicine ,education ,business.industry ,Risk Factor ,Percutaneous coronary intervention ,Settore MED/23 - Chirurgia Cardiaca ,EuroSCORE ,medicine.disease ,Aortic Valve Stenosi ,Prospective Studie ,Postoperative Complication ,business - Abstract
Background: Despite the widespread use of transcatheter aortic valve implantation (TAVI), the role of sex on outcome after TAVI or surgical aortic valve replacement (AVR) has been poorly investigated. We investigated the impact of sex on outcome after TAVI or AVR. Methods: There were 2108 patients undergoing TAVI or AVR who were enrolled in the Italian Observational Multicenter Registry (OBSERVANT). Thirty-day mortality, major periprocedural morbidity, and transprosthetic gradients were stratified by sex according to interventions. Results: Female AVR patients showed a worse risk profile compared with male AVR patients, given the higher mean age, prevalence of frailty score of 2 or higher, New York Heart Association class of 3 or higher, lower body weight, and preoperative hemoglobin level (P ≤.02). Similarly, female TAVI patients had a different risk profile than male TAVI patients, given a higher age and a lower body weight and preoperative hemoglobin level (P ≤.005), but with a similar New York Heart Association class, frailty score, EuroSCORE (P = NS), a better left ventricular ejection fraction and a lower prevalence of left ventricular ejection fraction less than 30%, porcelain aorta, renal dysfunction, chronic obstructive pulmonary disease, arteriopathy, and previous cardiovascular surgery or percutaneous coronary intervention (P ≤.01). Women showed a smaller aortic annulus than men in both populations (P
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21. Melatonin as adjuvant treatment in COVID-19 patients. A meta-analysis of randomized and propensity matched studies.
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Tóth, Krisztina, Pilia, Eros, Landoni, Giovanni, Oreggia, Davide, Giacomarra, Salvatore, Losiggio, Rosario, Maiucci, Giacomo, Vlasakov, Iliyan, Yavorovskiy, Andrey, Likhvantsev, Valery, Székely, Andrea, and Covello, Remo Daniel
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COVID-19 , *COVID-19 treatment , *CORONAVIRUS disease treatment , *MELATONIN , *SCIENTIFIC language - Abstract
Melatonin is a neurohormone well-known as sleep disorder treatment. A few clinical trials have recently pointed out the biological plausibility of utilising melatonin in the treatment of coronavirus disease 2019 (COVID-19, SARS-CoV-2) patients. Melatonin wide range of activities include anti-inflammatory, antiviral and antioxidant effects. Our meta-analysis aimed to investigate the effect of melatonin on mortality in COVID19 patients with different disease severity. We searched PubMed, EMBASE, Web of Science with no language restrictions updated on February 2023 for randomized and propensity matched studies, comparing melatonin plus standard COVID-19 therapy vs. standard COVID-19 therapy alone. Patients had to be hospitalised with a confirmed diagnosis of SARS-CoV-2 infection. Primary outcome was mortality at the longest follow-up available. We included 7 randomized and 1 propensity matched studies enrolling 1155 overall patients with a mean age of 61 ± 19.5 years. We found a reduced mortality rate in the overall population (127/575 (22%) vs. 209/580 (36%) Relative Risk: 0.62 (confidence interval (CI): 0.40, 0.96), I2 = 86% p = 0.03, with the results confirmed when pooling the 5 studies which administered melatonin in non-intensivecare-unit patients (26/423 (6.1%) vs. 69/419 (16%) Relative Risk 0.30 (CI: 0.10, 0.86), I 2 = 40% p = 0.02). According to recent randomized and propensity matched evidence, melatonin might be a life-saving adjuvant therapy in COVID-19 patients. This effect was mainly driven by non-intensive care unit patients. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Nonsurgical Strategies to Reduce Mortality in Patients Undergoing Cardiac Surgery: An Updated Consensus Process
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Miriam Labonia, Rosalba Lembo, Cristiano Amarelli, Giuseppe Bono, Remo Daniel Covello, Nora Di Tomasso, Daniela Pasero, Hynek Riha, Anna Mara Scandroglio, Claudio Riefolo, Nesrin Ahu Aslan, Carlo Leggieri, Rosetta Lobreglio, Giovanni Landoni, Valery V. Likhvantsev, Vladimir V. Lomivorotov, Gabriele Alvaro, Ludmilla Abrahao Hajjar, Alberto Zangrillo, Chiara Sartini, Martina Baiardo Redaelli, Massimo Baiocchi, Fabrizio Monaco, Giacomo Monti, Carmine D. Votta, Valentina Camarda, Paolo Mura, Evgeny Fominskiy, Alessandro Putzu, Emanuela Saporito, Antonio Pisano, Gianluca Paternoster, Rinaldo Bellomo, Simona Silvetti, Luca Brazzi, Giovanni Affronti, Stefano Turi, Agostino Roasio, Andrea Székely, Jun Ma, Caetano Nigro Neto, Landoni, Giovanni, Lomivorotov, Vladimir, Silvietti, Simona, Nigro Neto, Caetano, Pisano, Antonio, Alvaro, Gabriele, Hajjar, Ludmilla Abrahao, Paternoster, Gianluca, Riha, Hynek, Monaco, Fabrizio, Szekely, Andrea, Lembo, Rosalba, Aslan, Nesrin A., Affronti, Giovanni, Likhvantsev, Valery, Amarelli, Cristiano, Fominskiy, Evgeny, Baiardo Redaelli, Martina, Putzu, Alessandro, Baiocchi, Massimo, Ma, Jun, Bono, Giuseppe, Camarda, Valentina, Covello, Remo Daniel, Di Tomasso, Nora, Labonia, Miriam, Leggieri, Carlo, Lobreglio, Rosetta, Monti, Giacomo, Mura, Paolo, Scandroglio, Anna Mara, Pasero, Daniela, Turi, Stefano, Roasio, Agostino, Votta, Carmine D., Saporito, Emanuela, Riefolo, Claudio, Sartini, Chiara, Brazzi, Luca, Bellomo, Rinaldo, and Zangrillo, Alberto
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medicine.medical_specialty ,Consensus ,Cardiac Surgery ,Consensus Development Conferences as Topic ,Psychological intervention ,MEDLINE ,Consensu ,Review ,030204 cardiovascular system & hematology ,Perioperative Care ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Randomized controlled trial ,law ,Anesthesiology ,Intensive care ,medicine ,Humans ,030212 general & internal medicine ,Perioperative ,Cardiac Surgical Procedures ,Mortality ,Intensive care medicine ,cardiac surgery ,consensus ,mortality ,mortality reduction ,perioperative ,review ,Cardiology and Cardiovascular Medicine ,Anesthesiology and Pain Medicine ,Randomized Controlled Trials as Topic ,Internet ,business.industry ,Congresses as Topic ,Cardiac surgery ,Mortality reduction ,Bypass surgery ,TERAPÊUTICA MÉDICA ,business ,Mortality Reduction - Abstract
Objective: A careful choice of perioperative care strategies is pivotal to improve survival in cardiac surgery. However, there is no general agreement or particular attention to which nonsurgical interventions can reduce mortality in this setting. The authors sought to address this issue with a consensus-based approach. Design: A systematic review of the literature followed by a consensus-based voting process. Setting: A web-based international consensus conference. Participants: More than 400 physicians from 52 countries participated in this web-based consensus conference. Interventions: The authors identified all studies published in peer-reviewed journals that reported on interventions with a statistically significant effect on mortality in the setting of cardiac surgery through a systematic Medline/PubMed search and contacts with experts. These studies were discussed during a consensus meeting and those considered eligible for inclusion in this study were voted on by clinicians worldwide. Measurements and Main Results: Eleven interventions finally were selected: 10 were shown to reduce mortality (aspirin, glycemic control, high-volume surgeons, prophylactic intra-aortic balloon pump, levosimendan, leuko-depleted red blood cells transfusion, noninvasive ventilation, tranexamic acid, vacuum-assisted closure, and volatile agents), whereas 1 (aprotinin) increased mortality. A significant difference in the percentages of agreement among different countries and a variable gap between agreement and clinical practice were found for most of the interventions. Conclusions: This updated consensus process identified 11 nonsurgical interventions with possible survival implications for patients undergoing cardiac surgery. This list of interventions may help cardiac anesthesiologists and intensivists worldwide in their daily clinical practice and can contribute to direct future research in the field. Orion Pharma ; Abbott Laboratories ; Pall ; Tenax
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- 2018
23. Reply: TAVI in Lower Risk Patients: Revolution or Nonsense? Keep Calm and Select Patients.
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Barbanti M, Tamburino C, D'Errigo P, Ranucci M, Onorati F, Covello RD, Santini F, Rosato S, Santoro G, Fusco D, Grossi C, and Seccareccia F
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- Female, Humans, Male, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis surgery, Transcatheter Aortic Valve Replacement trends
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- 2016
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