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7. External validation of postoperative pancreatic fistula prediction scores in pancreatoduodenectomy: a systematic review and meta-analysis

Author

Pande, Rupaly, Halle-Smith, James M., Phelan, Liam, Thorne, Thomas, Panikkar, M., Hodson, James, Roberts, Keith J., Arshad, Ali, Connor, Saxon, Conlon, Kevin CP., Dickson, Euan J., Giovinazzo, Francesco, Harrison, Ewen, de Liguori Carino, Nicola, Hore, Todd, Knight, Stephen R., Loveday, Benjamin, Magill, Laura, Mirza, Darius, Pandanaboyana, Sanjay, Perry, Rita J., Pinkney, Thomas, Siriwardena, Ajith K., Satoi, Sohei, Skipworth, James, Stättner, Stefan, Sutcliffe, Robert P., and Tingstedt, Bobby

Published
2022
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10. Minimally invasive pancreatic resections: cost and value perspectives

Author

Asbun, Horacio J., Barkun, Jeffrey, Besselink, Marc G.H., Boggi, Ugo, Conlon, Kevin C.P., Han, Ho-Seong, Hansen, Paul D., Kendrick, Michael L., Kooby, David A., Montagnini, Andre L., Palanivelu, C., Røsok, Bård I., Shrikhande, Shailesh V., Wakabayashi, Go, Zeh, Herbert, Vollmer, Charles M., Conlon, Kevin C., de Rooij, Thijs, van Hilst, Jony, Abu Hidal, Mohammad, Fleshman, Julie, Talamonti, Mark, Vanounou, Tsafrir, Garfinkle, Richard, Velanovich, Vic, and Kooby, David

Published
2017
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13. Functional proteogenomics reveals biomarkers and therapeutic targets in lymphomas

Author

Rolland, Delphine C.M., Basrur, Venkatesha, Jeon, Yoon-Kyung, McNeil-Schwalm, Carla, Fermin, Damian, Conlon, Kevin P., Zhou, Yeqiao, Ng, Samuel Y., Tsou, Chih-Chiang, Brown, Noah A., Thomas, Dafydd G., Bailey, Nathanael G., Omenn, Gilbert S., Nesvizhskii, Alexey I., Root, David E., Weinstock, David M., Faryabi, Robert B., Lim, Megan S., and Elenitoba-Johnson, Kojo S. J.

Published
2017

14. Training in Minimally Invasive Pancreatic Resections: a paradigm shift away from “See one, Do one, Teach one”

Author

Asbun, Horacio J., Barkun, Jeffrey, Kendrick, Michael L., Kooby, David A., Hansen, Paul D., Vollmer, Charles M., Zeh, Herbert, Montagnini, André L., Besselink, Marc G.H., Boggi, Ugo, Conlon, Kevin C.P., Røsok, Bård Ingvald, Han, Ho-Seong, Palanivelu, C., Shrikhande, Shailesh V., Wakabayashi, Go, Hogg, Melissa E., Besselink, Marc G., Clavien, Pierre-Alain, Fingerhut, Abe, Jeyarajah, D. Rohan, Moser, A. James, Pitt, Henry A., Varban, Oliver A., Zeh, Herbert J., III, and Hansen, Paul

Published
2017
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15. Minimally invasive pancreatoduodenectomy

Author

Asbun, Horacio J., Barkun, Jeffrey, Besselink, Marc GH., Boggi, Ugo, Conlon, Kevin CP., Han, Ho-Seong, Hansen, Paul D., Kendrick, Michael L., Kooby, David A., Montagnini, Andre L., Palanivelu, C., Røsok, Bård I., Shrikhande, Shailesh V., Wakabayashi, Go, Zeh, Herbert, Vollmer, Charles M., van Hilst, Jony, de Rooij, Thijs, Walsh, R. Matthew, Zeh, Herbert J., Hughes, Steven J., and Nakamura, Yoshiharu

Published
2017
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17. Standardizing terminology for minimally invasive pancreatic resection

Author

Montagnini, Andre L., Røsok, Bård I., Asbun, Horacio J., Barkun, Jeffrey, Besselink, Marc G., Boggi, Ugo, Conlon, Kevin C.P., Fingerhut, Abe, Han, Ho-Seong, Hansen, Paul D., Hogg, Melissa E., Kendrick, Michael L., Palanivelu, Chinnusamy, Shrikhande, Shailesh V., Wakabayashi, Go, Zeh, Herbert, Vollmer, Charles M., and Kooby, David A.

Published
2017
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18. Worldwide survey on opinions and use of minimally invasive pancreatic resection

Author

van Hilst, Jony, de Rooij, Thijs, Abu Hilal, Mohammed, Asbun, Horacio J., Barkun, Jeffrey, Boggi, Uggo, Busch, Olivier R., Conlon, Kevin C.P., Dijkgraaf, Marcel G., Han, Ho-Seong, Hansen, Paul D., Kendrick, Michael L., Montagnini, Andre L., Palanivelu, Chinnusamy, Røsok, Bård I., Shrikhande, Shailesh V., Wakabayashi, Go, Zeh, Herbert J., Vollmer, Charles M., Kooby, David A., and Besselink, Marc G.H.

Published
2017
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19. Minimally invasive distal pancreatectomy

Author

Asbun, Horacio J., Barkun, Jeffrey, Besselink, Marc G., Boggi, Ugo, Conlon, Kevin, Han, Ho Seong, Hansen, Paul, Kendrick, Michael L., Kooby, David, Montagnini, Andre L., Palanivelu, Chinnasamy, Røsok, Bård I., Shrikhande, Shailesh V., Vollmer, Charles M., Wakabayashi, Go, Zeh, Herbert J., de Rooij, Thijs, van Hilst, Jony, Diener, Markus K., Allen, Peter J., and Kooby, David A.

Published
2017
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20. Research considerations in the evaluation of minimally invasive pancreatic resection (MIPR)

Author

Asbun, Horacio J., Barkun, Jeffrey, Besselink, Marc G.H., Boggi, Ugo, Conlon, Kevin C.P., Han, Ho-Seong, Hansen, Paul D., Kendrick, Michael L., Kooby, David A., Montagnini, Andre L., Palanivelu, C., Røsok, Bård I., Shrikhande, Shailesh V., Wakabayashi, Go, Zeh, Herbert, Vollmer, Charles M., Fisher, William, Davidson, Giana, Besselink, Marc, Pitt, Henry, Holt, Jane, Strasberg, Steve, Vollmer, Charles, and Kooby, David

Published
2017
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22. Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors

Author

O’Neill, Fiona, primary, Allen-Coyle, Taylor-Jade, additional, Roche, Sandra, additional, Meiller, Justine, additional, Conlon, Neil T., additional, Swan, Niall, additional, Straubinger, Robert M., additional, Geoghegan, Justin, additional, Straubinger, Ninfa L., additional, Conlon, Kevin, additional, McDermott, Ray, additional, O’Sullivan, Finbarr, additional, Henry, Michael, additional, Meleady, Paula, additional, McVey, Gerard, additional, O’Connor, Robert, additional, Moriarty, Michael, additional, and Clynes, Martin, additional

Published
2023
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23. 90 Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin’s lymphoma

Author

Janik, John E., Morris, John C., O’Mahony, Deirdre, Pittaluga, Stefania, Jaffe, Elaine S., Redon, Christophe E., Bonner, William M., Brechbiel, Martin W., Paik, Chang H., Whatley, Millie, Chen, Clara, Lee, Jae-Ho, Fleisher, Thomas A., Brown, Maggie, White, Jeffrey D., Stewart, Donn M., Fioravanti, Suzanne, Lee, Cathryn C., Goldman, Carolyn K., Bryant, Bonita R., Junghans, Richard P., Carrasquillo, Jorge A., Worthy, Tat’Yana, Corcoran, Erin, Conlon, Kevin C., and Waldmann, Thomas A.

Published
2015

29. Guidelines on Pancreatic Cystic Neoplasms: Major Inconsistencies With Available Evidence and Clinical Practice— Results From an International Survey

Author

Giovanni Marchegiani, Roberto Salvia, Andrianello Stefano, Balduzzi Alberto, Pollini Tommaso, Caravati Andrea, Maggino Laura, Zingaretti Caterina Costanza, Bassi Claudio, Abu Hilal Mohammed, Adham Mustapha, Adsay Volkan, Allen Peter, Arcidiacono Paolo, Barbu Sorin Traian, Basturk Olca, Besselink Marc, Brugge William, Bruno Marco, Büchler Markus, Cahen Djuna, Capurso Gabriele, Centeno Barbara, Conlon Kevin, Crippa Stefano, D'Onofrio Mirko, Dal Molin Marco, Das Koushik, Del Chiaro Marco, Dervenis Christos, Domínguez-Muñoz Juan Enrique, Esposito Irene, Falconi Massimo, Fernandez-del Castillo Carlos, Friess Helmut, Frigerio Isabella, Frulloni Luca, Furukawa Toru, Gabbrielli Armando, Gaujoux Sebastien, Ghaneh Paula, Gho Brian K. P, Gulbinas Antanas, Hackert Thilo, Hruban Ralph, Jang Jin-Young, Kim Sun Whe, Kimura Wataru, Kloeppel Günther, Lee Jeong Min, Lennon Anne Marie, Maker Ajay, Manfredi Riccardo, Matthaei Hanno, Mino-Kenudson Mari, Montagnini Andre Luis, Ohtsuka Takao, Radenkovic Dejan, Sahani Dushyant, Sahora Klaus, Sauvanet Alain, Scarpa Aldo, Schmidt Christian Max, Schulick Richard, Shrikhande Shailesh, Siriwardena Ajith, Smith Martin, Tanaka Masao, Vege Santhi Swaroop, Verbeke Caroline, Vollmer Charles, Werner Jens, Wolfgang Christopher, Wood Laura, Zamboni Giuseppe, and Zyromski Nicholas

Subjects
medicine.medical_specialty, Hepatology, business.industry, Patient Selection, Gastroenterology, International survey, Pancreatic Neoplasms, Clinical Practice, Health Care Surveys, Family medicine, Practice Guidelines as Topic, medicine, Humans, Pancreatic Cyst, Practice Patterns, Physicians', business, Societies, Medical
Published
2021

30. Abstract 3381: Establishment of a novel multi-omic biomarker panel in cyst fluid and blood for stratifying patient risk of pancreatic cancer

Author

Kane, Laura E., primary, Mellotte, Gregory S., additional, Lyons, Rebecca G., additional, Mylod, Eimear, additional, Marcone, Simone, additional, Ridway, Paul F., additional, MacCarthy, Finbar, additional, Conlon, Kevin C., additional, Lysaght, Joanne, additional, Ryan, Barbara M., additional, and Maher, Stephen G., additional

Published
2022
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31. Abstract CT147: Phase 1 study of recombinant interleukin 15 (rhIL-15) in combination with checkpoint inhibitors nivolumab and ipilimumab in subjects with refractory cancers

Author

Shin, Sarah J., primary, O'Sullivan Coyne, Geraldine, additional, Streicher, Howard, additional, Takebe, Naoko, additional, Bruns, Ashley, additional, Sharon, Elad, additional, Piekarz, Richard, additional, Juwara, Lamin, additional, Rubinstein, Larry, additional, Parchment, Ralph, additional, Fino, Kristin, additional, Fung, King L., additional, Ferry-Galow, Katherine, additional, Mittra, Arjun, additional, Naqash, Abdul Rafeh, additional, Conlon, Kevin, additional, Doroshow, James H., additional, and Chen, Alice P., additional

Published
2022
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32. EP1019: THE EFFECTS OF THE COVID-19 PANDEMIC ON PRESENTATIONS AND DIAGNOSIS OF UPPER GI AND HEPATOPANCREATICOBILIARY MALIGNANCIES

Author

Carroll, Andrew, primary, Costigan, Conor, additional, Gavin, Nicholas, additional, Walker, Caroline, additional, Ryan, Barbara M., additional, Breslin, Niall, additional, Mcnamara, Deirdre, additional, O'Donnell, Sarah, additional, Hayden, Una, additional, Ridgway, Paul, additional, Conlon, Kevin, additional, O'Morain, Colm A., additional, and O'Connor, Anthony, additional

Published
2022
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33. Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

Author

McDonnell, Scott R.P., Hwang, Steven R., Rolland, Delphine, Murga-Zamalloa, Carlos, Basrur, Venkatesha, Conlon, Kevin P., Fermin, Damian, Wolfe, Thomas, Raskind, Alexander, Ruan, Chunhai, Jiang, Jian-Kang, Thomas, Craig J., Hogaboam, Cory M., Burant, Charles F., Elenitoba-Johnson, Kojo S.J., and Lim, Megan S.

Published
2013
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36. International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice

Author

Asbun, Horacio J., Abu Hilal, Mohammad, Kunzler, Filipe, Asbun, Domenech, Bonjer, Jaap, Conlon, Kevin, Demartines, Nicolas, Feldman, Liane S., Morales-Conde, Salvador, Pietrabissa, Andrea, Pryor, Aurora D., Schlachta, Christopher M., Sylla, Patricia, Targarona, Eduardo M., Agra, Yolanda, Besselink, Marc G., Callery, Mark, Cleary, Sean P., De La Cruz, Luis, Eckert, Philippe, Evans, Chad, Han, Ho-Seong, Jones, Daniel B., Gan, Tong Joo, Koch, Daniel, Lillemoe, Keith D., Lomanto, Davide, Marks, Jeffrey, Matthews, Brent, Mellinger, John, Melvin, William Scott, Moreno-Paquentin, Eduardo, Navarrete, Claudio, Pawlik, Timothy M., Pessaux, Patrick, Ricciardi, Walter, Schwaitzberg, Steven, Shah, Paresh, Szokol, Joseph, Talamini, Mark, Torres, Ricardo, Triboldi, Alessandro, Udomsawaengsup, Suthep, Valsecchi, Federica, Vauthey, Jean-Nicolas, Wallace, Michael, Wexner, Steven D., Zinner, Michael, and Francis, Nader

Subjects
Infection Control, Consensus, Internationality, Delphi Technique, pandemic, resumption, pathways, coronavirus, COVID-19, Endoscopy, Delphi, surgery, backlog, Elective Surgical Procedures, recommendations, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, Triage, resources, Intersectoral Collaboration
Abstract

Supplemental Digital Content is available in the text, Objective: The aim of this work is to formulate recommendations based on global expert consensus to guide the surgical community on the safe resumption of surgical and endoscopic activities. Background: The COVID-19 pandemic has caused marked disruptions in the delivery of surgical care worldwide. A thoughtful, structured approach to resuming surgical services is necessary as the impact of COVID-19 becomes better controlled. The Coronavirus Global Surgical Collaborative sought to formulate, through rigorous scientific methodology, consensus-based recommendations in collaboration with a multidisciplinary group of international experts and policymakers. Methods: Recommendations were developed following a Delphi process. Domain topics were formulated and subsequently subdivided into questions pertinent to different aspects of surgical care in the COVID-19 crisis. Forty-four experts from 15 countries across 4 continents drafted statements based on the specific questions. Anonymous Delphi voting on the statements was performed in 2 rounds, as well as in a telepresence meeting. Results: One hundred statements were formulated across 10 domains. The statements addressed terminology, impact on procedural services, patient/staff safety, managing a backlog of surgeries, methods to restart and sustain surgical services, education, and research. Eighty-three of the statements were approved during the first round of Delphi voting, and 11 during the second round. A final telepresence meeting and discussion yielded acceptance of 5 other statements. Conclusions: The Delphi process resulted in 99 recommendations. These consensus statements provide expert guidance, based on scientific methodology, for the safe resumption of surgical activities during the COVID-19 pandemic.

Published
2020

38. Additional file 2 of Near infrared indocyanine green fluorescent cholangiography versus intraoperative cholangiography to improve safety in laparoscopic cholecystectomy for gallstone disease���a systematic review protocol

Author

Pavel, Mihai-Calin, Boira, Mar Achalandabaso, Bashir, Yasir, Memba, Robert, Ll��cer, Erik, Estalella, Laia, Juli��, Elisabeth, Conlon, Kevin C., and Jorba, Rosa

Abstract

Additional file 2. Search strategy for electronic databases (May 7th 2020).

Published
2022
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39. structure of nanomolecular memory , it is possible to substantially reduce the.pdf

Author

Rashid, Afshin, Conlon, Kevin, and Kamel, Basil

Abstract

By using the structure of nanomolecular memory , the size of memory bits can be substantially reduced, thereby increasing the density and efficiency of magnetic memory and lowering the cost and cost. Nanotechnology methods are now being used to provide some very powerful memories. Nanocrystals, the use of which willincrease the lifespan of flash memory. And the development of amagnetic material based on the protein ferritin, which will be usedto make disk drives and memory chips. The production andmanufacture of memory is one of the largest industrial sectors,but it also faces several technical problems; Problems such asleakage from the capacitor, structures with increasing complexity,and sensitivity to minor errors due to cosmic rays. The existenceof such problems makes it impossible for chip makers to reduce their chip dimensions beyond this. Nanoelectronics Science andTechnology Features of Nano Molecular Memory Offerdifferent. Photofraction materials, for example, represent only onetype of optical memory. In fact, using nanotechnology can

Published
2022
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40. Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors.

Author

O'Neill, Fiona, Allen-Coyle, Taylor-Jade, Roche, Sandra, Meiller, Justine, Conlon, Neil T., Swan, Niall, Straubinger, Robert M., Geoghegan, Justin, Straubinger, Ninfa L., Conlon, Kevin, McDermott, Ray, O'Sullivan, Finbarr, Henry, Michael, Meleady, Paula, McVey, Gerard, O'Connor, Robert, Moriarty, Michael, and Clynes, Martin

Subjects
PANCREATIC cancer, MICRORNA, PROTEINS, PANCREATIC tumors, XENOGRAFTS
Abstract

Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor, five adjacent normal, and eight FI PDX tumor samples and analyzed by Affymetrix GeneChip miRNA 4.0 array. A transcriptome analysis console (TAC) was used to generate comparative lists of up- and downregulated miRNAs for the comparisons, tumor vs. normal and F1 PDX vs. tumor. Particular attention was paid to miRNAs that were changed in the same direction in both comparisons. We identified the involvement in pancreatic tumor tissue of several miRNAs, including miR4534, miR3154, and miR4742, not previously highlighted as being involved in this type of cancer. Investigation in the parallel mRNA and protein lists from the same samples allowed the elimination of proteins where altered expression correlated with corresponding mRNA levels and was thus less likely to be miRNA regulated. Using the remaining differential expression protein lists for proteins predicted to be targeted for differentially expressed miRNA on our list, we were able to tentatively ascribe specific protein changes to individual miRNA. Particularly interesting target proteins for miRs 615-3p, 2467-3p, 4742-5p, 509-5p, and 605-3p were identified. Prominent among the protein targets are enzymes involved in aldehyde metabolism and membrane transport and trafficking. These results may help to uncover vulnerabilities that could enable novel approaches to treating pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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42. A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma

Author

Sahasrabuddhe, Anagh Anant, primary, Chen, Xiaofei, additional, Ma, Kaiyu, additional, Wu, Rui, additional, Kapoor, Richa, additional, Chhipa, Rishi Raj, additional, Zhang, Xiao, additional, Onder, Ozlem, additional, Wilmore, Joel, additional, Gaudette, Brian T., additional, Pillai, Vinodh, additional, Li, Marilyn M., additional, Ahn, Joon-Young, additional, Chung, Fuzon, additional, Szankasi, Philippe, additional, Basrur, Venkatesha, additional, Conlon, Kevin P, additional, Bailey, Nathanael G., additional, Hogaboam, Cory M, additional, Rottapel, Robert, additional, Kim, Junhyong, additional, Lopez, Cristina, additional, Seufert, Julian, additional, Schlesner, Matthias, additional, Siebert, Reiner, additional, Cancro, Michael P, additional, Allman, David, additional, Pagano, Michele, additional, Staudt, Louis M., additional, Lim, Megan S., additional, and Elenitoba-Johnson, Kojo S. J., additional

Published
2021
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43. Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

Author

Conlon, Kevin, primary, Watson, Dionysios C, additional, Waldmann, Thomas A, additional, Valentin, Antonio, additional, Bergamaschi, Cristina, additional, Felber, Barbara K, additional, Peer, Cody J, additional, Figg, William D, additional, Potter, E Lake, additional, Roederer, Mario, additional, McNeel, Douglas G, additional, Thompson, John A, additional, Gupta, Sumati, additional, Leidner, Rom, additional, Wang-Gillam, Andrea, additional, Parikh, Nehal S, additional, Long, Debby, additional, Kurtulus, Sema, additional, Ho Lee, Lang, additional, Chowdhury, Niladri Roy, additional, Bender, Florent, additional, and Pavlakis, George N, additional

Published
2021
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44. Postpancreatectomy Acute Pancreatitis (PPAP)

Author

Marchegiani, Giovanni, Barreto, Savio George, Bannone, Elisa, Sarr, Michael, Vollmer, Charles M, Connor, Saxon, Falconi, Massimo, Besselink, Marc G, Salvia, Roberto, Wolfgang, Christopher L, Zyromski, Nicholas J, Yeo, Charles J, Adham, Mustapha, Siriwardena, Ajith K, Takaori, Kyoichi, Hilal, Mohammad Abu, Loos, Martin, Probst, Pascal, Hackert, Thilo, Strobel, Oliver, Busch, Olivier RC, Lillemoe, Keith D, Miao, Yi, Halloran, Christopher M, Werner, Jens, Friess, Helmut, Izbicki, Jakob R, Bockhorn, Maximillian, Vashist, Yogesh K, Conlon, Kevin, Passas, Ioannis, Gianotti, Luca, Del Chiaro, Marco, Schulick, Richard D, Montorsi, Marco, Oláh, Attila, Fusai, Giuseppe Kito, Serrablo, Alejandro, Zerbi, Alessandro, Fingerhut, Abe, Andersson, Roland, Padbury, Robert, Dervenis, Christos, Neoptolemos, John P, Bassi, Claudio, Büchler, Markus W, and Shrikhande, Shailesh V

Published
2021

45. Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study

Author

van Veldhuisen, Eran, Klompmaker, Sjors, Janssen, Quisette P., Hilal, Mohammed Abu, Alseidi, Adnan, Balduzzi, Alberto, Balzano, Gianpaolo, Bassi, Claudio, Berrevoet, Frederik, Bonds, Morgan, Busch, Olivier R., Butturini, Giovanni, Conlon, Kevin C., Frigerio, Isabella M., Fusai, Giuseppe K., Gagnière, Johan, Griffin, Oonagh, Hackert, Thilo, Halimi, Asif, Keck, Tobias, Kleeff, Jörg, Klaiber, Ulla, Labori, Knut J., Lesurtel, Mickael, Malleo, Giuseppe, Marino, Marco V., Molenaar, I. Quintus, Mortensen, Michael B., Nikov, Andrej, Pagnanelli, Michele, Pandé, Rupaly, Pfeiffer, Per, Pietrasz, Daniel, Rangelova, Elena, Roberts, Keith J., Cunha, Antonio Sa, Salvia, Roberto, Strobel, Oliver, Tarvainen, Timo, Wilmink, Johanna W., Koerkamp, Bas Groot, Besselink, Marc G., Sauvanet, Alain, Marthey, Lysiane, Laurent, Christophe, Régenet, Nicolas, Coriat, Romain, Taieb, Julien, Turini, Olivier, Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Internal medicine, University of Helsinki, Clinicum, HUS Abdominal Center, and II kirurgian klinikka

Subjects
Complications, LAPC, Folfrinox, OS, Folfrinox, BRPC, LAPC, OS, Definition, Classification, 3126 Surgery, anesthesiology, intensive care, radiology, Gemcitabine, SDG 3 - Good Health and Well-being, Oncology, Medicine and Health Sciences, Surgery, BRPC
Abstract

Background Preoperative FOLFIRINOX chemotherapy is increasingly administered to patients with borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) to improve overall survival (OS). Multicenter studies reporting on the impact from the number of preoperative cycles and the use of adjuvant chemotherapy in relation to outcomes in this setting are lacking. This study aimed to assess the outcome of pancreatectomy after preoperative FOLFIRINOX, including predictors of OS. Methods This international multicenter retrospective cohort study included patients from 31 centers in 19 European countries and the United States undergoing pancreatectomy after preoperative FOLFIRINOX chemotherapy (2012–2016). The primary end point was OS from diagnosis. Survival was assessed using Kaplan-Meier analysis and Cox regression. Results The study included 423 patients who underwent pancreatectomy after a median of six (IQR 5–8) preoperative cycles of FOLFIRINOX. Postoperative major morbidity occurred for 88 (20.8%) patients and 90-day mortality for 12 (2.8%) patients. An R0 resection was achieved for 243 (57.4%) patients, and 259 (61.2%) patients received adjuvant chemotherapy. The median OS was 38 months (95% confidence interval [CI] 34–42 months) for BRPC and 33 months (95% CI 27–45 months) for LAPC. Overall survival was significantly associated with R0 resection (hazard ratio [HR] 1.63; 95% CI 1.20–2.20) and tumor differentiation (HR 1.43; 95% CI 1.08–1.91). Neither the number of preoperative chemotherapy cycles nor the use adjuvant chemotherapy was associated with OS. Conclusions This international multicenter study found that pancreatectomy after FOLFIRINOX chemotherapy is associated with favorable outcomes for patients with BRPC and those with LAPC. Future studies should confirm that the number of neoadjuvant cycles and the use adjuvant chemotherapy have no relation to OS after resection.

Published
2021

47. Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52+T-cell malignancies

Author

Miljkovic, Milos D., Dubois, Sigrid P., Müller, Jürgen R., Bryant, Bonita, Ma, Elaine, Conlon, Kevin C., and Waldmann, Thomas A.

Abstract

•Treatment with IL-15 before alemtuzumab was safe and led to decreased number and proliferative activity of T-cell leukemic cells.•IL-15 was associated with increased activation and proliferation of patient-derived NK and CD8+T cells, increasing their ADCC capacity.

Published
2023
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50. International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice From the Coronavirus Global Surgical Collaborative

Author

Asbun, Horacio J., Abu Hilal, Mohammad, Kunzler, Filipe, Asbun, Domenech, Bonjer, Jaap, Conlon, Kevin, Morales Conde, Salvador, Francis, Nader, and Universidad de Sevilla. Departamento de Cirugía

Subjects
Endoscopic, Surgical, COVID-19, Delphi
Abstract

Objective: The aim of this work is to formulate recommendations based on global expert consensus to guide the surgical community on the safe resumption of surgical and endoscopic activities. Background: The COVID-19 pandemic has caused marked disruptions in the delivery of surgical care worldwide. A thoughtful, structured approach to resuming surgical services is necessary as the impact of COVID-19 becomes better controlled. The Coronavirus Global Surgical Collaborative sought to formulate, through rigorous scientific methodology, consensus-based recommendations in collaboration with a multidisciplinary group of international experts and policymakers. Methods: Recommendations were developed following a Delphi process. Domain topics were formulated and subsequently subdivided into questions pertinent to different aspects of surgical care in the COVID-19 crisis. Forty-four experts from 15 countries across 4 continents drafted statements based on the specific questions. Anonymous Delphi voting on the statements was performed in 2 rounds, as well as in a telepresence meeting. Results: One hundred statements were formulated across 10 domains. The statements addressed terminology, impact on procedural services, patient/staff safety, managing a backlog of surgeries, methods to restart and sustain surgical services, education, and research. Eighty-three of the statements were approved during the first round of Delphi voting, and 11 during the second round. A final telepresence meeting and discussion yielded acceptance of 5 other statements. Conclusions: The Delphi process resulted in 99 recommendations. These consensus statements provide expert guidance, based on scientific methodology, for the safe resumption of surgical activities during the COVID-19 pandemic.

Published
2021

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