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Tracing the evolutionary milestones of our species has been the focus of much exciting research. Yet, we are still unable to ‘locate' the divergence point of our cognitive evolution, which has made us so unique in the animal kingdom (Tomasello & Rakoczy, 2003). We have identified a gap in our understanding, and that is the absence of a systematic exploration into the symbiotic relationship between Homo sapiens and fungi. This highly interdisciplinary symposium aims to address this oversight, emphasizing the important – yet underappreciated – role of fungi in cognitive contexts and challenge traditional views of cognition.

Pointing is an intuitive and commonplace communication modality. In human-robot collaborative tasks, human pointing has been modeled using a variety of approaches, such as the forearm vector or the vector from eye to hand. However, models of the human pointing vector have not been uniformly or comprehensively evaluated. We performed a user study to compare five different representations of the pointing vector and their accuracies in identifying the human's intended target in an object selection task. We also compare the vectors' performances to that of domestic dogs to assess a non-human baseline known to be successful at following human points. Additionally, we developed an observation model to transform the vector into a probability map for object search. We implemented our system on our robot, enabling it to locate and fetch the user's desired objects efficiently and accurately.

Humans learn and generate languages, music, games, and seemingly limitless varieties of other structures across domains. Unlike many AI systems, we often do so from little data. How do we learn such large varieties of richly structured representations so efficiently? One possibility is that people ``learn by programming,'' synthesizing data-generating algorithms to explain what we observe. We examine the nature and origins of this learning mechanism in adults, children, and nonhuman primates (macaque monkeys), using a highly unconstrained sequence prediction task. Although adults and children quickly learn many richly structured sequences, monkeys learn only the simplest sequences (e.g. lines). We test multiple learning models, finding that adults are best explained by a ``Language of Thought''-like program-learning model and monkeys by a simpler extrapolation strategy. Children exhibit varied learning strategies but are best fit in aggregate by an intermediately expressive model. Paper available at https://sites.google.com/view/patternlearning.

Theory of Mind (ToM) is central to human social cognition, yet the roots of this capacity remain poorly understood. Both infants and nonhuman primates perform inconsistently on false belief tasks, limiting our understanding of the representations that characterize their ToM. Here, we seek to better understand this often-contradictory literature by dissecting these failures. Specifically, we focus on primates' characteristic null performance on false belief tasks. Across three studies, we find that—despite succeeding on a closely-matched control—rhesus monkeys fail to predict how agents with false beliefs will behave even when the agents perform highly unexpected, unlikely actions. We interpret this pattern of performance as evidence that monkeys have no representation of another agent's past awareness once the scene changes outside of that agent's view. This work moves beyond the success/failure dichotomy typically used to assess ToM, and instead gives a more precise characterization of primates' signature limits in ToM.

Spontaneous internally directed attention, such as mind wandering, typically hinders performance in cognitive tasks. The impact of intentional internally directed attention (IDA) – for instance, deliberately thinking about past or future events – on task performance, however, remains unclear. In our study, we employed a dual-task paradigm that involved self-referential stimuli in a color-recall visual working memory task. This approach revealed that intentional IDA more significantly influences performance compared to intentional externally directed attention (EDA). We observed larger late positive potentials (LPP) over medial frontal sensors, suggesting sustained stimulus processing over frontal sensors under IDA. Additionally, we noted a pattern of neural activity associated with internal attention: event-related desynchronization (ERD) in the alpha band (8-12 Hz) during the encoding phase and event-related synchronization (ERS) in the delay phase. In contrast, the EDA condition was marked by theta (4-8 Hz) band ERS during the delay period. These findings highlight distinct behavioral impacts and neural patterns associated with internally versus externally directed attention in dual-task settings.

Languages tend to describe who is doing what to whom by placing subjects before objects. This bias for agents is reflected in event cognition: agents capture more attention than patients in human adults and infants. We investigated whether this agent preference is unique to humans. We presented Guinea baboons (Papio papio, N = 13) with a change detection paradigm with chasing animations. The baboons had to respond to a colour change which was applied to either the chaser/agent or the chasee/patient. They were faster to detect a change to the chaser than to the chasee, which cannot be explained by low-level features in our stimuli. Our study suggests that baboons show an agent preference similar to human infants and adults. This may be an evolutionarily old mechanism that is shared between humans and other primates, which could have become externalised in language as a tendency to place the subject first.

Age-related memory decline is a multifaceted and heterogeneous process. Previous studies on working memory and episodic memory have demonstrated that older participants' memory for item-context bindings (e.g. the location in which an object appeared) drops dramatically, while memory for individual items is relatively preserved. Here, we extend this research in two ways: first, we study memory for ordered object sequences with spatial context, rather than single objects. Second, we investigate how blocked versus interleaved learning curricula affect independent (or marginal) sequence memory (i.e., which objects appeared, and which spatial locations were seen) versus joint sequence memory (which objects appeared where) for older versus younger adults. Across two behavioral experiments with 108 younger (18-35 years) and 100 older (over 65 years) adults, we found better memory for object sequences than position sequences and worst performance for joint object-position sequence reports in both age-groups. Notably, age differences in memory performance followed the same pattern, being least pronounced for sequential object memory and most for joint object-position sequences. Changing the learning curriculum such that either object or spatial location sequences repeated across times, rather than occurring in an interleaved fashion, improved memory performance in both age groups, but had a stronger effect on older than younger adults, suggesting that blocked learning curricula can help older adults with reallocation of limited cognitive resources.

Object Permanence (OP) is the understanding that objects continue to exist when not directly observable. To date, this ability has proven difficult to build into AI systems, with Deep Reinforcement Learning (DRL) systems performing significantly worse than human children. Here, DRL Agents, PPO and Dreamer-v3 were tested against a number of comparators (Human children, random agents and hard coded Heuristic agents) on three object permanence tasks (OP) and a range of control tasks. As expected, the children performed well across all tasks, while performance of the DRL agents was mixed. Overallthe pattern of performance across OP and control tasks did not suggest that any agent tested except children showed evidence of robust OP.

Traditional conceptions of inference emphasize explicit following of logical rules, often tied to the possession of natural language, thereby implying that non-human animals cannot make inferences. However, comparative research shows extensive evidence of the success of several species of non-human animals in nonverbal reasoning tasks, putting pressure on the traditional view. We deny two traditional assumptions about inference: the lingualism of thought, and the requirement of explicit rule following. We suggest instead a multidimensional model of inference illustrated through several case studies. Thereby, we categorize informational transfers across three dimensions by marking the degree of context-independence, the format of representation, and the type of perspectivity involved. By allowing for a more nuanced interpretation of empirical data than the traditional view, our framework is able to accommodate inferential behaviors of both linguistic and non-linguistic agents, and shed light on varied manifestations of inference across species and developmental stages.

We studied individual differences in broadcasters' multimodal adult-directed and child-directed communication. Forty-six female future broadcasters simulated live broadcasts for both adults and children. Effects of speakers' individual styles, empathy and the Big Five personality traits on adult-directed and child-directed language (e.g., prosody, linguistic features and gestures) were examined. Results showed that all multimodal cues in adult-directed and child-directed language were highly correlated, but there were larger individual variations in the degree of adjustments between the two language registers. Moreover, empathy and certain personality traits could not only predict multimodal language production, but also the degree of adjustments for child-directed communication. For example, higher-empathetic participants speak faster, louder with a higher pitch, use diverse but more frequent words, and produce more salient referential gestures. In conclusion, despite an individual language style, empathy and the Big Five personality traits influence speakers' multimodal language production and the degree of audience design.

This study compares creativity test performance in Individual versus Team settings, addressing a gap in research that mostly focuses on individual outcomes. A total of 120 individuals participated in two sessions. The first session involved cognitive assessments, including the Advanced Progressive Matrices (APM), the Creative Reasoning Test (CRT), and the Test for Creative Thinking–Drawing Production (TCT-DP), as well as mood and personality questionnaires. In the second session, participants were assigned to either an Individual or a Team condition (N=3 each), based on and controlling for APM scores. The same assessments, except for the personality questionnaire, were conducted in this second session. In the Team condition, members were encouraged to collaborate in solving the tasks. We tested whether the conditions have a differential effect on the second session performances, particularly on divergent and convergent thinking scores in CRT, and/or on TCT-DP scores and/or on APM scores.

Linguistic strategies humans use for communication are designed to meet the informational needs of their addressees. Speakers not only adapt their speech but also increase the rate of iconic gestures to enhance the clarity of a message for children. Although sign languages allow signers to take advantage of iconicity far more than what is possible in speech, little is known about whether signers use iconicity as a strategy in child-directed communication. In the present study, we used automatic video pose estimation to analyze descriptions aimed at a child (12yo) vs. an adult produced by 7 deaf adult signers of Italian Sign Language. Overall, signers used iconic constructions more than lexical signs and with comparable frequency in descriptions for both age groups. However, iconic constructions were longer in duration for children. Thus, the present study presents the first evidence that, unlike speakers, signers do not modulate quantitative but only qualitative aspects of iconicity for children.

The ability to manipulate and recognize abstract representations seems to be a fundamental aspect of human nature, existing since the dawn of our species and transcending cultural barriers. In contrast, non-human primates exhibit very limited proficiency in recognizing abstract representations. This research delves into this human singularity for visual abstraction, through neuroimaging experiments conducted in both humans and non-human primates. Stimuli presenting the same concept (e.g. a house or a face) but varying in abstraction levels (photos, drawings, symbols, and words) were initially presented to a monkey, while intracranial recording of his brain were obtained (16 Utah arrays distributed in V1, V4 and IT). Preliminary results indicate that monkey display early signs of abstraction, particularly for evolutionarily ancient categories such as faces. MEG and fMRI recordings of human subjects are also currently underway, striving to unveil the neuronal mechanisms that set our species apart in the domain of visual abstraction.

Electric vehicles (EVs) are quickly replacing internal combustion cars, which will soon become obsolete. Nonetheless, how drivers' perception and cognition deal with certain features of EVs remains largely unknown. In this study we focus on the role of in-car sound, specifically the artificial engine sounds, on drivers' speed perception and control. Previous studies indicate that removing or reducing engine sound leads drivers to underestimate speed and, consequently, to drive faster. Furthermore, evidence suggests that specific sound frequencies could play a role in this process, highlighting the importance of in-car sound features. We consider benefits and limitations of different research paradigms used in the field (mostly video based technique and driving simulation) and we propose an experimental protocol to systematically investigate the phenomenon. Finally, we suggest that the wider use of psychophysical methods on video recordings would benefit the research in the field and overcome some limitations of simulation studies.

Previous research has effectively employed the fast-paced action puzzle video-game Tetris for understanding the acquisition of extreme expertise in complex, dynamic environments. A common approach when contrasting expert to novice performance has been the dissection of their interactions with the environment into disjoint sub-tasks – such as Reaction Time (RT), measured by the input latency to new events on screen. The crucial, underlying assumption to this paradigm is task consistency at all levels of expertise. Using data collected from participants of the Tetris World Championship 2019 and from novices in our lab, we show that this assumption does not hold. While for novices the RT task type remains the same across all conditions, for experts - depending on environmental parameters - the nature of the RT task undergoes a shift and under specific conditions does not represent a RT task anymore. Thus, expert vs. novice sub-task comparison may not be a valid paradigm.

While students typically prefer multiple-choice learning, open-answer questions have frequently been found to be more effective, attributed to their role in promoting recall as opposed to recognition. Here, we examine increasing the effectiveness of multiple-choice testing as a learning tool, by using foils (incorrect answer options) that are similar in meaning and word form to the correct answer. Participants studied French-Dutch vocabulary in three learning conditions: one with unrelated foils, another with open questions, and a third using multiple choice questions with related foils. The related foils were either semantically or orthographically similar to the correct answer. The results showed no significant difference between the open questions and the related foils condition, indicating comparable effectiveness. Replicating earlier studies, the unrelated foils condition yielded significantly poorer learning outcomes. Overall, these results suggest that multiple-choice testing can be a viable alternative to open answer testing when utilizing related foils.

Human bodies follow similar designs. Yet, languages differ in how they divide the body into parts to name them (Brown 1976; Enfield et al. 2006; Majid et al. 2015; Huisman et al. 2021). In this study, we investigate the similarities and differences in naming two separate body parts with the same word, i.e., colexifications. Using a computational approach, we analyze networks of body part vocabularies across 1,028 languages. The analyses focus on the influence of perceptual features that lead to variations in body part colexification networks and on a comparison of network structures in different semantic domains. Results reveal that adjacent body parts are frequently colexified, while variations in vocabularies are influenced by perceptual features like shape and function. Compared to semantic domains like emotion and color, body part colexification networks show less variation across language families. This research presents the first large-scale comparison of body part vocabularies and provides important insights into the variability of a universal human domain.

Many ceramic materials transform to a solid-solution intermediate state before amorphization under extreme conditions. Combining in-situ irradiation experiments and ab initio molecular dynamics simulations, we performed a comparative study of the defect accumulation process in MAX phases, Ti 2 AlC, Cr 2 AlC, and Ti 2 SnC, to clarify the correlation between solid-solution intermediate phase properties and phase instability. It is found that phase stability strongly depends on the lattice distortion of the solid-solution intermediate state, rather than the defect energies in the initial phases that were previously believed as the indicator of the resistance to the irradiation-induced amorphization. Larger lattice distortions of the solid-solution intermediate state can hinder defect recombination and lead to faster collapse to an amorphous state. This work provides a new research insight into phase instability for ceramic materials under extreme conditions. [ABSTRACT FROM AUTHOR]

Background Limitations exist with current ACLR functional testing assessments that may be mitigated by including single-leg multi-directional testing. Hypothesis/Purpose To compare Anterior Cruciate Ligament-Return to Sport after Injury Scale (ACL-RSI) scores, limb symmetry index (LSI) of the single-leg vertical jump (SLVJ), single-leg medial rotation hop (SLMRH), single-leg lateral hop (SLLH), and isokinetic quadriceps strength between participants with an ACLR and healthy controls and assess predictors of quadriceps strength asymmetry. It was hypothesized that ACL-RSI scores and LSIs for all tests would differ between ACLR and healthy control groups and within the ACLR group a strong correlation would exist between all outcome measures and quadriceps strength. Study Design Cross-Sectional Study Methods Twenty-six participants with an ACLR (median 13 months after surgery) and twenty-six matched healthy controls were recruited to participate in this study. Performance was assessed via SLVJ, SLMRH, SLLH, and isokinetic quadriceps strength. Between-group comparisons were made with independent t-tests and Mann-Whitney U test. Within the ACLR group, bivariate correlation and multivariate regression analysis were performed to assess the relationship between the outcome measures and quadriceps strength asymmetry. Results Significant between-limb differences were only identified in the ACLR group (p< 0.05): SLVJ LSI: 88.5%, SLMRH LSI: 93.6%, SLLH LSI: 92.7%, quadriceps strength LSI 80.9% - 83.9%, which were significantly lower (p <0.05) than the healthy control group. Within the ACLR group, a moderate-strong significant (p < 0.05) correlations existed with quadriceps strength and SLVJ (r=0.44-0.65), SLMRH (r =0.43-0.83), and SLLH (r=0.54-0.63); while ACL-RSI had a weak non-significant (p > 0.05) correlation with quadriceps strength (r= 0.12-0.30). Conclusion Single-leg multidirectional test LSIs were less in ACLR participants than matched healthy controls and all were directly related to quadriceps strength. Psychological readiness to return to sport was not related to quadriceps strength. [ABSTRACT FROM AUTHOR]

• Three TEC techniques gave consistent values of shell height over East Africa. • New method suggested agree with that of Nava et al.,. (2007) and Li et al.,. (2017). • Over East Africa the value of the effective height is about 400 km. The ionosphere over the low latitude region, where East Africa falls, is associated with high perturbations arising from numerous phenomenon such as Equatorial Ionization Anomaly (EIA), plasma bubbles, electrostatic instabilities etc. All these together, make it difficult to determine the actual values of important parameters used to characterize the ionosphere of the region in order to mitigate its negative contribution to technology. One such parameter is the effective height which is used among others to map the Total electron Content (TEC) over a given region, in argumentation, calibration of Global Navigation Satellite System (GNSS) observations etc. The value of the effective height of a place is got by radiosounders installed in a given location. However, these sounders are not readily available in many places, especially East Africa where the few that are available are currently malfunctioning and also their ionospheric spatial coverage is very limited. Alternative techniques that use TEC from GNSS receivers to estimate effective height of the ionosphere have been suggested and employed in different places, giving results that in some instances conflict with each other. This study has done a comparative analysis of the suggested GNSS-TEC techniques to determine their reliability over low latitude region of East Africa and has found out that some of them do not give consistent results over the region. To supplement the existing methods, a new method is proposed that relates IRI TEC to TEC obtained from the difference between sTEC recorded simultaneously by a given receiver on ground and the receiver on board Swarm satellite when swarm is over head the ground receiver. The results obtained using the new suggested technique gives consistent results over East African region which is in agreement with two other techniques among the four methods discussed. [ABSTRACT FROM AUTHOR]

In our research laboratory, we have developed an absorber composed of various materials and structures. This absorber comprised the following layers arranged from top to bottom: a cubic array layer of titanium and silicon dioxide (SiO2), a magnesium fluoride dielectric layer (MgF2), and an aluminum substrate. Previously, we employed finite difference time domain (FDTD) simulations to identify optimal parameters for this structure and subsequently applied them to COMSOL simulations. The optimal parameters determined through FDTD simulations resulted in an average absorptivity of 95.2% within the wavelength range from 400 to 1500 nm. However, when these parameters were applied to COMSOL simulations, the average absorptivity within the same wavelength range decreased to 93.7%. Subsequently, we utilized COMSOL to adjust various parameters in order to identify the optimal ones. Our investigation focused on exploring the impact of different parameters such as material thicknesses, absorber structures, electromagnetic field distributions, and incident angles on the absorptivity. Through this comprehensive analysis, we aimed to refine our understanding of how these parameters affect the absorptivity performance of the structure. This research not only contributes to the optimization of absorber design but also enhances our knowledge of the underlying physical mechanisms governing light absorption in such structures. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to identify risk factors contributing to the early onset of patellofemoral osteoarthritis (PFOA) within the first two years following anterior cruciate ligament reconstruction (ACLR) using a hamstring tendon autograft. Methods: Participants aged 18 to 40 who had undergone ACLR within the past two years were included in this study, along with a control group of healthy volunteers. Magnetic resonance imaging (MRI) data were obtained preoperatively, at two years postoperatively, and from the control group. T-tests were used to assess differences in patellofemoral alignment (PA) and trochlear morphology (TM) between the pre- and post-ACLR patients and healthy controls. The incidence of PFOA was recorded, and associations between PA, TM, and clinical parameters were evaluated in patients with and without PFOA. Logistic regression analysis was conducted to identify potential risk factors for PFOA development. Results: A total of 177 patients, with a mean follow-up period of 22.17 ± 5.09 months and a mean age of 26.4 ± 5.6 years, were included in the study. Following ACL injury, significant alterations in patellar tilt angle (PTA), tuberositas tibae-trochlear groove distance (TT-TG), Insall-Salvati ratio (ISR), and static anterior tibial translation (SATT) were observed compared to the control group. Postoperatively, deviations in PTA and SATT remained significant when compared to healthy controls. Of the 177 patients, 68 (38.42%) developed early-onset PFOA. Factors associated with the early onset of PFOA included age at the time of surgery, the interval between injury and surgery, PTA, bisect offset (BO), sulcus angle (SA), thigh circumference, SATT, and partial meniscectomy. Conclusion: Significant differences in PTA, TT-TG, ISR, and SATT were identified between patients who underwent ACLR and healthy controls. Postoperatively, there was no correction in PTA or SATT, which remained significantly altered. Factors such as age at the time of surgery, PTA, BO, SA, ISR, SATT, thigh circumference, partial meniscectomy, and the time interval between injury and surgery were associated with the early onset of PFOA within two years post-ACLR. These findings may aid in the prevention of PFOA by identifying individuals at higher risk for early development. [ABSTRACT FROM AUTHOR]

Background: The Universal Infant Free School Meal (UIFSM) policy was introduced in 2014/15 in England and Scotland for schoolchildren aged 4–7 years, leading to an increase in school meal uptake. UK school meals are known to be healthier and less industrially processed than food brought from home (packed lunches). However, the impact of the UIFSM policy on the quantity of ultra-processed food (UPF) consumed at school during lunchtime is unknown. This study aimed to evaluate the impact of the UIFSM policy on lunchtime intakes of UPF in English and Scottish schoolchildren. Methods: Data from the UK National Diet and Nutrition Survey (2008–2019) were used to conduct a difference-in-difference (DID) natural experiment. Outcomes included school meal uptake and the average intake of UPF (% of total lunch in grams (%g) and % total lunch in Kcal (%Kcal)) during school lunchtime. The change in the outcomes before and after the introduction of UIFSM (September 2014 in England, January 2015 in Scotland) in the intervention group (4–7 years, n = 835) was compared to the change in an unexposed control group (8–11 years, n = 783), using linear regression. Inverse probability weights were used to balance characteristics between intervention and control groups. Results: Before UIFSM, school meal uptake and consumption of UPFs were similar in the intervention and control groups. The DID model showed that after UIFSM, school meal uptake rose by 25%-points (pp) (95% CI 14.2, 35.9) and consumption of UPFs (%g) decreased by 6.8pp (95% CI -12.5,-1.0). Analyses indicated this was driven by increases in minimally processed dairy and eggs, and starchy foods, and decreases in ultra-processed salty snacks, bread and drinks. The differences were larger in the lowest-income children (-19.3 UPF(%g); 95% CI -30.4,-8.2) compared to middle- and high-income children. Analyses using UPF %Kcal had similar conclusions. Conclusions: This study builds on previous evidence suggesting that UIFSM had a positive impact on dietary patterns, showing that it reduced consumption of UPFs at school lunchtime, with the greatest impact for children from the lowest-income households. Universal free school meals could be an important policy for long term equitable improvements in children's diet. [ABSTRACT FROM AUTHOR]

Background: The postgraduate curriculum needs to be given a definite shape so as to make health programs more intensive and integrative. In the present scenario, most of the information is unclear and infrequent. A structured public health competency-based education is an important aspect to consider for integrative health care. Evaluate the structured competency-based curriculum (SCBC) prepared on health program matters. Methods: Mixed method model involving postgraduate students, faculties in community medicine departments of selected medical colleges and stakeholders from district administration. The SCBC was piloted and validated for use. The evaluation was then done based on pre- and posttest performance analysis, satisfaction survey, and questionnaires for reaction and learning components. Results: For a complete understanding of the program, students had to invest 52 hours of stipulated time. CBC assessment mean scores for a) problems in PHC and programmatic evaluation (78.9%) and b) identification of success and failure of programs (78.2%) were more than 75% mean score; whereas, assessment scores for topics on a) resource allocation and b) evaluation of program as write-up was 65% and 52%, respectively. As compared to the conventional method, the SCBC showed a critical evaluation score of 70% with a 0.001 significance level. Discussion and Conclusion: Students' narratives were that they could understand as well as integrate them better on the field. There was enhanced satisfaction and encouragement. Structured curriculum will also help in making learning more student-centric and go a long way in boosting their creativity. [ABSTRACT FROM AUTHOR]

E. coli and total coliforms are the most widely used indicator organisms for microbial monitoring of drinking water and recreational freshwater. In many remote and low-resource settings, however, conventional laboratory methods for quantifying these indicators are challenging or infeasible to perform due to limited access to laboratory facilities. The availability of rapid, low-cost methods for quantifying indicator organisms in freshwater samples without the need for laboratory facilities is crucial to facilitate the rapid and robust monitoring of microbial water quality in these types of settings. The global misuse and abuse of antimicrobials have contributed to the rise of antimicrobial resistance. Thus, simple culture methods are needed to detect indicators of such bacteria in freshwaters. In 2021, the World Health Organization released the Tricycle protocol to address this issue by providing guidance for culture-based detection of extended-spectrum beta-lactamase (ESBL)-producing E. coli in environmental samples. Our research goal was to compare the 100-ml sample volume ESBL E. coli quantal and enumerative commercial tests against the more complex Tricycle protocol to detect and quantify ESBL E. coli in surface waters. Both commercial tests gave results comparable with the results obtained using the Tricycle protocol, and the quantal and enumerative commercial tests were easier and faster to perform than the Tricycle protocol. [ABSTRACT FROM AUTHOR]

This paper investigates the behavior of a medical guidewire within a vessel with a specific focus on its buckling, commonly known as tip load. The guidewire is simulated as a variable section microshaft embedded in an elastic environment, and a comprehensive buckling analysis is carried out based on the modified couple stress theory (MCST). The fundamental frequency is determined by applying Hamilton's principle and Rayleigh's method. A formula for calculating the buckling force is subsequently introduced. Numerical simulations were conducted to analyze the impact of the material properties, tapered tip length, core thickness, slenderness ratio, and material length scale parameter on the tip load and penetration force. Furthermore, a comparative study was carried out to validate the proposed formulation. The findings derived from this research can provide valuable insights for the optimization and exploration of various parameters related to medical guidewires. The findings indicate that coronary guidewires with lengths exceeding 10 cm exhibit minimal variations in tip load, whereas those with lengths below this threshold experience a substantial decrease of 65–75% in both tip load and penetration force when the length is doubled. In addition, nitinol guidewires demonstrate greater flexibility, with their tip load being nearly 75% lower than that of stainless steel guidewires of equivalent dimensions. Moreover, there is a notable increase in penetration force with an expanding radius, with tapered tips resulting in an approximate 20–30% increase in penetration force. [ABSTRACT FROM AUTHOR]

The converse flexoelectric effect can be applied to control thin-shell structures. In this paper, the vibration control of a conical shell with multiple flexoelectric actuators is studied. In order to investigate the actuation performance of the flexoelectric patch, this study analyzes the electric field gradient, modal forces, and displacement of a conical shell driven by the flexoelectric patch and their relationships with the design parameters. In the physical model, the AFM probe is positioned on the upper surface of the flexoelectric patch to create a high-intensity non-uniform electric field within the flexoelectric actuator. In turn, generates internal stress in the flexoelectric actuator patch through the converse flexoelectric effect. The case study shows that the high-intensity non-uniform electric field generated by the AFM probe has nearly zero contribution to the electric field in areas far from the contact point. As a result, the stress generated by the converse flexoelectric effect primarily concentrates near the AFM probe, with the size and shape of the flexoelectric patches having minimal influence on the actuation. Based on the assumption of small deformation and linear displacement, considering the vibration control of multiple flexoelectric actuators on the truncated conical shell, the lateral displacement results controlled by multiple flexoelectric actuators can be calculated by the superposition principle. When multiple flexoelectric actuators work together, the same flexoelectric actuator in different positions may induce opposite lateral displacements at a specific point on the surface of the truncated conical shell. This can result in the cancellation of vibrational displacements produced by the flexoelectric actuators. Approximate optimal distribution positions for the multi-channel flexoelectric actuators were determined through experimental simulations. In this study, the superior vibration suppression capabilities of multi-channel flexoelectric actuators are highlighted through a comparative analysis with single-channel configurations, demonstrating their effectiveness in controlling complex vibration modes in conical shell structures. [ABSTRACT FROM AUTHOR]

Numerous studies indicate that unsafe behaviors of construction workers (UBCW) are the direct causes of most construction safety incidents. To unveil the interconnections among unsafe behaviors and the underlying mechanisms of different accident types, this study extracts the unsafe behavior chains from accidents. Based on the theory of complex networks, we constructs both the whole network of UBCW and four subnetworks corresponding to different accident types by using unsafe behavior chains. The findings reveal that the degree distributions of all networks conform to truncated power-law distributions, highlighting the critical role of hub nodes in accident occurrences. Moreover, the whole network exhibits small-world characteristics, underscoring the need to address the propagation and clustering effects of unsafe behaviors, reassess risk management approaches, and devise targeted control strategies and measures. By analyzing the topological structures of the networks, this paper ranks the importance of different behaviors across various metrics and proposes tailored accident prevention recommendations through comparative analysis of different accident types. This research holds significant theoretical and practical implications for refining accident causality models and enhancing safety management practices at construction sites. However, the study has limitations, notably future studies should focus on the absence of specific construction accident databases and the unaddressed link between accident severity and unsafe behaviors. [ABSTRACT FROM AUTHOR]

This study introduces a non-convex fractional-order hyper-Laplacian variational model for Gaussian noise removal. It employs first the primal-dual hybrid gradient algorithm to solve problems involving overlapping group sparse structures. Additionally, this paper designs a new algorithm leveraging the framework of the Chambolle-Pock algorithm with convergence and aims to recover high-quality images. The model, integrating the overlapping group sparse structure of the hyper-Laplacian prior with the non-convex fractional-order total variation, exhibits superior performance in reducing the staircase effect and maintaining sharp edge contours. To further improve the performance of the algorithm, a semi-adaptive p (x) non-convex penalty weight assignment mechanism is designed by introducing the structure tensor, which according to the characteristics of each region of the image and the noise level. The effectiveness and superiority of the proposed algorithm in image denoising with simulation experiments and comparative analyses are fully verified. • A new non-convex fractional-order hyper-Laplace variation model is proposed. • The PDHG algorithm is introduced to solve optimization problems involving OGS-HL for the first time. • The convergence and complexity of the new design algorithm are analyzed. • A semi-adaptive p (x) determined by the structure of the image and the noise level is designed. [ABSTRACT FROM AUTHOR]

This paper introduces a novel Multi-Level Inverter (MLI) design which utilizes a single input and leverages capacitor voltages source to generate a four-fold increase in output voltage as the main problem that stays with the inverters is their low boost ability and efficiency while maintaining power quality at the same time. One capacitor is charged to match the input voltage magnitude, while the other two capacitors store twice this magnitude. Through a series-parallel combination with switching operations, all capacitors are effectively charged and discharged within each cycle, ensuring natural voltage balance. A comprehensive comparative analysis is conducted to highlight the advantages of this innovative approach, particularly in terms of component reduction and mitigation of voltage stress. Detailed assessment of power losses within the proposed circuit is undertaken, simulation studies are first carried out while extensive experimentation verifies its operational efficiency under diverse conditions such as varying modulation indices, loads, and supply-side fluctuations with an impressive maximum efficiency of 96.9 % at a 200 W power rating, our research contributes to advancing compact power converters, addressing crucial challenges in modern power electronics applications, and paving the way for enhanced performance and reliability in such systems. [ABSTRACT FROM AUTHOR]

Background The rotator cuff (RC) plays a pivotal role in the performance and health of the shoulder and upper extremity. Blood flow restriction training (BFRT) is a modality to improve strength and muscle hypertrophy with even low-load training in healthy and injured individuals. There is minimal evidence examining its effect proximal to the occluded area, and particularly on the RC. Hypothesis & Purpose The purpose of this case series is to explore the effects of low-load BFRT on RC strength, hypertrophy, and tendon thickness in asymptomatic individuals. Study Design Case series. Methods Fourteen participants with asymptomatic, untrained shoulders were recruited to participate. They performed an eight-week low-load shoulder exercise regimen where BFR was applied to the dominant arm only during exercise. The dependent variables were maximal isometric strength of the shoulder external rotators(ER) and elevators (in the scapular plane in full can position) (FC) measured via handheld dynamometry, cross sectional area (CSA) of the supraspinatus and infraspinatus muscles, and supraspinatus tendon thickness measured via ultrasound imaging (US). Mean changes within and between arms were compared after training using paired t-tests. Cohen's d was used to determine effect sizes. Results All participants were able to complete the BFRT regimen without adverse effects. Mean strength and CSA increased for all variables in both arms, however this increase was only significant (p<0.01) for FC strength bilaterally and CSA for the supraspinatus and infraspinatus on the BFRT side. The effect sizes for increased supraspinatus and infraspinatus CSA on the BFRT side were 0.40 (9.8% increase) and 0.46 (11.7% increase) respectively. There were no significant differences when comparing the mean changes of the BFRT side to the non-BFRT side for strength or muscle CSA. There were no significant changes to supraspinatus tendon thickness. Conclusion These results suggest variability in response of the RC musculature to low-load BFRT in asymptomatic individuals. The potential for a confounding systemic response in the study design makes determining whether low-load BFRT is more beneficial than low-load non-BFRT difficult. The hypertrophy seen on the BFRT side warrants further study. Level of Evidence 4 [ABSTRACT FROM AUTHOR]

Background Reduced dorsiflexion range of motion (DFROM) which is commonly seen following lateral ankle sprain (LAS) has the potential to influence lower extremity biomechanics which have been linked to increased injury risk in the female athlete. Current research on the effect of sex and LAS history on DFROM is limited. Hypothesis/Purpose This study had three aims 1) to determine the effect of sex, leg dominance and LAS history on DFROM, 2) to determine the effect of sex and LAS history on magnitude of DFROM symmetry and 3) to examine the association of sex on direction (whether dominant or non-dominant limb had the higher DFROM) of symmetry. Study Design Cross-Sectional Study Methods DFROM was measured bilaterally in 105 recreational athletes all participating in multidirectional sports using the tape measurement method during the weight bearing lunge test (WBLT). A mean of three measurements was used for analysis. A 3-way mixed ANOVA was carried out to determine the interaction between sex, LAS history and leg dominance on DFROM and a 2-way ANOVA for the effect of sex and LAS history on asymmetry. A chi-square test was used to determine the association of sex and direction of asymmetry. Results The results indicate no significant effect of sex, LAS history, and leg dominance on DFROM (p=0.65). Main effects were significant for sex and LAS on DFROM. The mean asymmetry for all participants was reported as 12.25±14.76cm. No significant effect of sex and LAS history on magnitude of asymmetry was reported. There was a significant association of sex and direction of asymmetry (χ²(1) = 11.26, p = 0.00). Sixty-five-point two percent of males were shown to have higher DFROM of their non-dominant limb compared to 75% of females who were higher in their dominant limb. Conclusion Findings from this study suggest that DFROM is affected by sex and LAS history. While females have increased DFROM compared to males, those with LAS history are more likely to have a decreased DFROM on the involved side. The results also indicate that interlimb asymmetries in DFROM are present in athletes, therefore practitioners should exercise caution when using bilateral comparisons in injury and return to play assessments. Level of Evidence 2b. [ABSTRACT FROM AUTHOR]

Background Secondary anterior cruciate ligament (ACL) injury is a complication of ACL reconstruction (ACLR), which may result from altered neuromuscular control affecting anticipatory postural adjustments (APAs) and compensatory postural adjustments (CPAs) required for maintaining balance during movement. However, it remains unclear how APAs and CPAs differ in single-leg landings post-ACLR compared to healthy subjects. Purpose The purpose of this study was to clarify the differences in muscle activities of APAs and CPAs, lower limb kinematics, and kinetics between athletes with a history of ACLR and healthy athletes during single-leg landing. Study design Cross-sectional study. Methods Eighteen female athletes were recruited and divided into ACLR (n = 9) and control groups (n = 9). The experimental task involved a single-leg landing from a 30 cm box. Joint angles and moments were determined using a 3-dimensional motion analysis system, while muscle activity was assessed using surface electromyography. Analysis intervals were divided into two phases: the APA phase (-150 ms to 50 ms) and the CPA phase (50 ms to 250 ms), with initial contact (0 ms) as the reference point. Muscle activity onset time was defined as the time when the baseline exceeded by the sum of mean values and 2 standard deviations. Results No significant differences were observed in muscle activity or onset time between the ACLR and control groups. However, an increased hip external rotation moment was observed during the CPA phase in the ACLR group. Conclusion These findings suggest that APAs and CPAs of athletes who returned to sports more than 1 year post-ACLR may be similar. The increased hip external rotation moment in the ACLR group during the CPA phase could represent a specific compensatory strategy to decrease the hip internal rotation angle post-ACLR. Level of Evidence III [ABSTRACT FROM AUTHOR]

Background Muscular strength deficits are common after ACL injury. While the Limb Symmetry Index (LSI), using the uninvolved limb as a reference, is widely used, negative strength adaptations may affect both limbs post-injury. It is uncertain how the strength of the uninvolved limb in those with an ACL injury compares to uninjured individuals, making it unclear whether it is appropriate as a benchmark for determining sufficient strength. Purpose To compare the strength of key lower extremity muscles of the uninvolved limb in those with history of ACL injury (ACL-I) to the dominant limb in individuals with no history of ACL injury (control). Study Design Cross-sectional study. Methods: A total of 5,727 military cadets were examined, with 82 females and 126 males in the ACL-I group and 2,146 females and 3,373 males in the control group. Maximum isometric strength was assessed for six muscle groups measured with a hand-held dynamometer. Separate two-way ANOVAs with limb and sex were performed for each muscle group. Results Significant main effects for limb were observed with the uninvolved limb in the ACL-I group displaying greater strength compared to the dominant limb in the control group for the quadriceps, hamstrings, and gluteus medius, but effect sizes were small (Cohen's d <0.25). Significant main effects for sex were observed with greater male muscular strength in all six muscle groups with small to large effect sizes (Cohen's d 0.49-1.46). No limb-by-sex interactions were observed. Conclusions There was no evidence of reduced strength in the uninvolved limb in those with a history of ACL injury compared to the dominant limb in those with no prior ACL injury. This finding suggests that, after clearance to return to activities, the uninvolved limb can be used as a standard for comparison of sufficient strength, including when using the LSI. Level of Evidence: Level 3 [ABSTRACT FROM AUTHOR]

RF power amplifier (RF PA) finds its application in almost all the areas of electronics, mobile communication being identified as a major area. The paper performs a comparative efficiency analysis of RF power amplifiers operating with a fixed bias and an envelope tracking bias. Simulations are performed using Keysight advanced design system (ADS) tool. A class a RF PA operating at a 12 dB gain is fixed for the work. 16 QAM LTE signal operating at 5 MHz input frequency, with a peak to average power ratio (PAPR) of 6.0 dB is used as input signal. An envelope simulation at 2.5 GHz is performed on the RF power amplifier. Simulation result shows an improvement of 12% in power added efficiency (PAE) at 6 dB back-off and 6.422% in mean PAE while using envelope tracking power amplifiers, compared to RF PA with fixed supply. Envelope tracking power amplifiers reduced AM/AM distortions also by a factor of 0.248. The results obtained are much better than that obtained using a conventional RF PA with fixed bias. RF PA being the most power dissipative block in a mobile handset, improving its efficiency contributes directly to a great improvement in the battery lifetime of mobile phones. The major challenges faced by envelope tracking PA (ETPA) designers in achieving this efficiency improvement is also delineated in the paper. [ABSTRACT FROM AUTHOR]

Background: Skin commensal bacteria (Staphylococcus epidermidis) can help defend against skin infections, and they are increasingly being recognized for their role in benefiting skin health. This study aims to demonstrate the activities that Myristica fragrans Houtt. seed extracts, crude extract (CE) and essential oil (EO), have in terms of promoting the growth of the skin commensal bacterium S. epidermidis and providing metabolites under culture conditions to disrupt the biofilm formation of the common pathogen Staphylococcus aureus. Methods: The culture supernatant obtained from a co-culture of S. epidermidis with M. fragrans Houtt. seed extracts in either CE or EO forms were analyzed using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography tandem mass spectrometry (LC-MS/MS), in silico investigations, and applied to assess the survival and biofilm formation of S. aureus. Results: The combination of commensal bacteria with M. fragrans Houtt. seed extract either CE or EO produced metabolic compounds such as short-chain fatty acids and antimicrobial peptides, contributing to the antimicrobial activity. This antimicrobial activity was related to downregulating key genes involved in bacterial adherence and biofilm development in S. aureus, including cna, agr, and fnbA. Conclusion: These findings suggest that using the culture supernatant of the commensal bacteria in combination with CE or EO may provide a potential approach to combat biofilm formation and control the bacterial proliferation of S. aureus. This may be a putative non-invasive therapeutic strategy for maintaining a healthy skin microbiota and preventing skin infections. [ABSTRACT FROM AUTHOR]

Background: This study evaluates the clinical evidence for performing total knee arthroplasty (TKA) without a tourniquet, a shift from the near-universal use in 2009 to current trends towards tourniquet-less TKA in Norway and Sweden. This change is set against a backdrop of conflicting evidence regarding the positive and negative effects of tourniquet use. Questions/purposes: The aims were to determine if the tourniquet has an impact on [1] Forgotten Joint Score-12 (FJS-12) at 8 weeks after surgery; [2] postoperative strength and function; [3] postoperative pain and opioid analgesic use; and [4] operative time, bleeding, and length of stay (LOS). Methods: Eighty-one patients were randomised to TKA with or without a tourniquet. The outcome measures, FJS-12, muscle strength, functional test, pain, estimated blood loss, haemoglobin (Hb) loss, knee circumference, opioid consumption, and LOS were assessed preoperatively and at 1 day, 8 weeks, and 1 year after surgery. Results: No significant difference in FJS-12 scores was found between the two groups at postoperative 8 weeks. However, the tourniquet group showed statistically significant better knee extension strength at 8 weeks (p = 0.045). There were no differences in other outcomes, except for a greater decrease in haemoglobin levels (p = 0.02) and higher estimated perioperative blood loss (p < 0.001) in the no tourniquet group than the torniquet group. Conclusions: Our study indicates that tourniquet use during TKA causes no significant differences in FJS-12 at 8 weeks, significantly reduces bleeding and postoperative Hb loss, and improves quadriceps strength at 8 weeks. Trial registration: Clinicaltrails.gov. Registry Number: NCT03666598. Registered 30 August 2018. [ABSTRACT FROM AUTHOR]

Introduction: Artificial cervical disc replacement (ACDR) is a widely accepted surgical procedure in the treatment of cervical radiculopathy and myelopathy. However, some research suggests that ACDR may redistribute more load onto the facet joints, potentially leading to postoperative axial pain in certain patients. Earlier studies have indicated that facet tropism is prevalent in the lower cervical spine and can significantly increase facet joint pressure. The present study aims to investigate the changes in the biomechanical environment of the cervical spine after ACDR using different prosthese when facet tropism is present. Methods: A C2-C7 cervical spine finite element model was created. Symmetrical, moderate asymmetrical (7 degrees tropism), and severe asymmetrical (14 degrees tropism) models were created at the C5/C6 level by adjusting the left-side facet. C5/C6 ACDR with Prestige LP, Prodisc-C vivo, and Mobi-C were simulated in all models. A 75 N follower load and 1 N⋅m moment was applied to initiate flexion, extension, lateral bending, and axial rotation, and the range of motions (ROMs), facet contact forces(FCFs), and facet capsule stress were recorded. Results: In the presence of facet tropism, all ACDR models exhibited significantly higher FCFs and facet capsule stress compared to the intact model. In the asymmetric model, FCFs on the right side were significantly increased in neutral position, extension, left bending and right rotation, and on both sides in right bending and left rotation compared to the symmetric model. All ACDR model in the presence of facet tropism, exhibited significantly higher facet capsule stresses at all positions compared to the symmetric model. The stress distribution on the facet surface and the capsule ligament in the asymmetrical models was different from that in the symmetrical model. Conclusions: The existence of facet tropism could considerably increase FCFs and facet capsule stress after ACDR with Prestige-LP, Prodisc-C Vivo, and Mobi-C. None of the three different designs of implants were able to effectively protect the facet joints in the presence of facet tropism. Research into designing new implants may be needed to improve this situation. Clinical trials are needed to validate the impact of facet tropism. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical efficacy of autologous platelet rich plasma (PRP) injection in the treatment of knee osteoarthritis (KOA) and its influence on related biomarkers such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). Method: 150 study subjects are randomly selected from KOA patients received treatment in the Third Hospital of Bethune Hospital from January 2022 to January 2023. After enrollment, patients are randomly numbered 1–100. 75 patients with odd and even numbers are included in the control group and the observation group, respectively. The former is cured with etocoxib, while the latter is treated with autologous PRP injection based on this. The clinical efficacy, relevant biomarkers (IL-1β, TNF-α, hs-CRP), and Lysholm knee score scale and Fugl Meyer assessment (FMA) scores are compared and analyzed. Results: The total effective rate of 94.67% (71/75) in the observation group was higher than 84.00% (63/75) in the other one group (P < 0.05). Before treatment, the comparison in IL-1β, TNF-α, hs-CRP, Lysholm knee joint score, and FMA scale score are with P > 0.05. When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels within the group were lower than before treatment, while the Lysholm knee joint score and FMA scale score were higher than before treatment (P < 0.05). When the treatment period is at 1 and 2 months, the IL-1β, TNF-α, hs-CRP levels and the Lysholm knee joint and FMA scale scores in the observation group were lower and higher than those in the other one group, respectively (P < 0.05). Conclusion: The application of autologous PRP injection therapy in KOA patients can significantly improve their levels of related biomarkers, effectively improve knee joint function and motor function, and have good clinical efficacy. [ABSTRACT FROM AUTHOR]

Background: Early marriage, the formal or informal union before age 18, remains a critical challenge in several low-and middle-income countries. It has adverse health and education-related implications on child brides. This study examined the regional distribution of early marriage and its associated factors in Ghana. Methods: We performed a cross-sectional analysis of data extracted from the 2022 Ghana Demographic and Health Survey. Our study comprised 10,098 ever married/cohabiting aged 15 to 49. Regional variations in the prevalence of child marriage were visualised using a spatial map. A mixed-effect multilevel binary logistic regression analysis was performed to assess the factors associated with early marriage. The results were presented as adjusted odds ratios (aOR) with a 95% confidence interval (CI). Results: The prevalence of early marriage was 29.2% [27.9, 30.6] in Ghana. Women in the North East 38.2% [33.4, 43.2], Western North 36.7% [32.1, 41.5] and Ahafo regions 35.8% [32.0, 39.8] had the highest prevalence of early marriage, whilst women in the Western 22.2% [18.4, 26.5] and Greater Accra 19.7% [15.8, 24.3 regions] had the lowest prevalence of early marriage in Ghana. The odds of early marriage was lower among women aged 20-49 compared to those aged 15-19. Women with secondary [aOR = 0.40; 95% CI 0.33, 0.48] and higher education [aOR = 0.07; 95% CI 0.04, 0.12], those who belonged to the Gurma ethnic group [aOR = 0.59; 95% CI 0.41, 0.84], and women from richer [aOR = 0.64; 95% CI: 0.47, 0.87] and richest [aOR = 0.42; 95% CI 0.28, 0.64] households were less likely to be married early compared to those with no education, those belonging to the Akan ethnic group, and those from the poorest wealth quintile households, respectively. The odds of early marriage was higher among women whose family size was five or more [aOR = 1.50; 95% CI 1.31, 1.72] and women living in the Central [aOR = 1.72; 95% CI 1.16, 2.54], Volta [aOR = 1.97; 95% CI 1.17, 3.30], Eastern [aOR = 1.53; 95% CI 1.01, 2.29], Ashanti [aOR = 1.98; 95% CI 1.33, 2.97], Western North [aOR = 1.77; 95% CI 1.18, 2.65], and Ahafo regions [aOR = 1.74; 95% CI 1.18, 2.56]. Conclusion: About one in three marriages were early in Ghana, with variations across the regions. Age, wealth index, ethnicity, level of education, family size, and region were identified as factors associated with early marriages. The government and policymakers in Ghana should increase access to and completion of secondary education for girls, as it is crucial in reducing early marriage. Providing programmes that economically empower women and girls can decrease their vulnerability to early marriage. More vigorous enforcement of laws against early marriage is necessary. Engaging with communities, including tribal leaders, is essential to shift cultural attitudes toward early marriage. [ABSTRACT FROM AUTHOR]

Introduction: Poly (ADP‐ribose) polymerase (PARP) inhibitor has been widely used in ovarian cancer patients carrying BRCA mutations. However, resistance to PARP inhibitor is present in some patients, and no effective treatment is available for these patients. TH‐302 is a hypoxia‐activated prodrug, which releases the bis‐DNA alkylator bromo‐isophosphoramide mustard (Br‐IPM) under hypoxic condition. The present study aims to determine whether TH‐302 is effective in treating PARP inhibitor resistance. Methods: The in vitro cytotoxicity of TH‐302 was assessed by short‐term proliferation assay (50% inhibitory concentration, IC50) or long‐term clonogenic assay (90% inhibitory concentration, IC90) under various oxygen concentrations. In vivo efficacy of TH‐302 was assessed in PARP inhibitor resistance, partially responsive and sensitive patient‐derived xenograft (PDX) or cell line–derived xenograft (CDX) models. Antitumor activity via homologous recombination (HR) pathway for TH‐302 was evaluated using DLD1 BRCA2 knockout cell line and BRCA/RAD51D deleterious mutant PDX/CDX models. Breaks of double‐strand DNA and hypoxia fraction in tumors were determined by gamma histone 2AX (γH2AX) and pimonidazole immunohistochemistry in H460 CDX model following treatment. Results: Cytotoxicity was significantly enhanced under hypoxia in 12 human cancer cell lines including four ovarian cancer cell lines. The cytotoxicity was 70 times higher in human colon cancer cell line with BRCA2 knock out compared to wild type under hypoxia following TH‐302 treatment. γH2AX staining revealed that the cytotoxicity of TH‐302 was associated with DNA damage. In addition, administration of TH‐302 with olaparib led to better antitumor activities than either single drug/prodrug in olaparib‐resistant PDX models. Conclusion: TH‐302 exhibits hypoxia‐dependent cytotoxicity across a wide range of human cancer cell lines, and may be a drug candidate to treat ovarian cancer, bladder cancer, and pancreatic cancer with HR deficiencies with or without resistance to PARP inhibitor. TH‐302 may be effective in recurrent epithelial ovarian cancer (EOC) with homologous recombination deficiency (HRD) or in EOC patients resistant to PARP inhibitors. [ABSTRACT FROM AUTHOR]

Background: Newly graduated registered nurses face more challenges than their experienced counterparts, as they not only confront the high pressures of an increasingly complex medical environment but also need to quickly adapt to their jobs and role transitions. The emotional burden arising at this stage is referred to as transitional shock. Self‐depletion, as proposed by Baumeister, refers to the process by which individuals exhaust their internal psychological control resources when facing challenges, subsequently affecting cognition and emotion. The occurrence of transitional shock and the process of individual self‐depletion appear to be closely related. However, to our knowledge, there has been limited research exploring the occurrence of transitional shock from the perspective of self‐depletion theory. Aim: Investigating the emergence process of transition shock through the lens of self‐depletion theory entails an examination of the mechanisms by which individuals engage in self‐regulation when confronted with challenges and how transition shock manifests throughout this process. Designs: A descriptive qualitative study. Methods: Between August and November 2023, using maximum variation sampling and purposive sampling methods, 16 nurses were selected for semistructured interviews at a tertiary hospital in Suzhou, China. Results: Employing thematic analysis, three interconnected themes were identified, encompassing the entry‐level workforce challenges, the subsequent effects of energy depletion, and the sources and replenishment of energy. Conclusion: As new nurses adapt to their roles and environments, they encounter numerous pressures that markedly drain their psychological energy. This ongoing depletion of self‐regulation energy can lead to transitional shock, impulsive decision‐making, and missed nursing care. Implications for Nursing Management: Managers should implement comprehensive support strategies, including optimized work environments, enhanced training, and personal development, to help newly graduated nurses successfully transition and improve care quality and retention. [ABSTRACT FROM AUTHOR]

Background: Bleeding complications following intramuscular (IM) injections are generally considered rare with reported incidence of 0.06%. However, evidence on safety of IM injections among anticoagulated hospitalized patients is lacking. The objective of the current study was to examine the incidence of injection site bleeding complications following IM injection among anticoagulated hospitalized patients. Methods: A retrospective comparative study comprised of all hospitalized patients ≥ 18 years old that were treated with ≥ 1 IM injection between 2009 and 2019 in a large tertiary medical center. Bleeding complications were defined as focal hematoma, local bleeding, intramuscular bleeding or compartment syndrome. Each case with IM injection was searched for ICD9 codes (e.g., hematoma, hemorrhage or compartment syndrome) and for indirect evidence suggestive of potential bleeding: hemoglobin drop ≥ 2 g/dl, AST or CPK increase, packed red blood cell transfusion, or abrupt cessation of the anticoagulation. These case were then verified for true injection-site bleeding by natural language processing model and manual review of the electronic medical record. Results: A total of 71,710 patients were treated with 236,406 IM injections. Mean age 53 (± 22) and 63% were females. Concomitant anticoagulation (Heparins: 90.3%, warfarin: 6.8% and DOACs: 4.7%) occurred in 40,819 IM injections (8189 patients). Suspected bleeding complications at the IM injection site were identified among 7,111 patients following 23,089 IM injections, the majority were unrelated to the IM injection-site (e.g., gastrointestinal bleeding, retroperitoneal, etc.). Two cases were verified as true injection site bleeding complication, both in the anticoagulated group (2/8189, 0.02%). Conclusion: Bleeding complications at site of IM injections among anticoagulated hospitalized patients are rare, and their risk is probably not higher compared to patients without anticoagulation. [ABSTRACT FROM AUTHOR]

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease with poor outcomes when untreated, in which ravulizumab or eculizumab are the standard of care where available. It has been proposed to regularly monitor platelet counts as an early response to ravulizumab or eculizumab. This study aimed to investigate the association between the early response to ravulizumab treatment and renal outcomes through 26 weeks in complement inhibitor-naïve adults with aHUS. Methods: Adult patients with aHUS enrolled in the ALXN1210-aHUS-311 phase III study of ravulizumab were divided into two groups according to the achievement of complete thrombotic microangiopathy (TMA) response, i.e., platelet count and lactate dehydrogenase (LDH) normalization and ≥ 25% improvement in serum creatinine (sCr) from baseline, by 26 weeks and baseline characteristics were compared. Changes in hematologic parameters, platelet count and LDH, were compared between the two groups. Finally, we examined whether early hematologic improvement was associated with renal recovery (dialysis discontinuation or ≥ 25% improvement in sCr from baseline) through 26 weeks. Results: Of 56 ravulizumab-treated patients, 30 achieved complete TMA response for 26 weeks, and 26 did not. Patients with complete TMA response showed rapid improvements in platelet counts. In patients without complete TMA response, delayed normalization of platelet counts was observed. By day 15, 93.3% (28/30) of patients with complete TMA response at 26 weeks and 26.9% (7/26) of patients without complete TMA response achieved platelet normalization. At 26 weeks, 62.5% (35/56) achieved renal recovery; however, 37.5% (21/56) did not. In patients with renal recovery, 85.7% (30/35) of patients had platelet count normalization by day 15; in patients without renal recovery, 23.8% (5/21) of patients had platelet count normalization (P < 0.0001). Receiver operator characteristic curve analysis showed a moderate association between platelet counts on day 8/15 and renal recovery within 26 weeks (day 8: area under the curve [AUC] = 0.7985; day 15: AUC = 0.8406). Conclusions: Platelet count normalization occurred in 62.5% (35/56) by day 15 after ravulizumab initiation and was associated with renal recovery through 26 weeks in complement inhibitor-naïve adults with aHUS. Trial registration: This study was performed as a post-hoc analysis of the ALXN1210-aHUS-311 phase III clinical trial (NCT02949128, registered October 25, 2016). [ABSTRACT FROM AUTHOR]

Objective: To analyse the correlation between urinary albumin excretion rate (UAER) and estimated glomerular filtration rate (eGFR) and the risk factors for reducing eGFR in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 431 T2DM patients admitted between January 2019 and March 2020 were selected and divided into two groups according to eGFR level. Comparing the differences between baseline data and clinical indicators, multivariate logistic regression was used to analyse the risk factors of eGFR reduction and to analyse the association between UAER and eGFR. Results: In total, 167 patients were included in the study group and 264 patients were included in the conventional group. The study group participants were older, had longer diabetes duration, and had higher fatty liver, peripheral vascular disease (PVD), hypertension prevalence, and mean body mass index (P < 0.05). The levels of various indicators were lower than those of the conventional group (P < 0. 05). Additionally, PVD, nocturnal systolic blood pressure, fatty liver, and beta-2-microglobulin (β 2-MG) were independent risk factors for eGFR decline, with high density lipoprotein (HDL) and fasting C-peptide (CP) as protective factors. There was no obvious correlation between UAER and eGFR. Conclusion: Peripheral vascular disease, systolic blood pressure, fatty liver, and beta-2-microglobulin are risk factors for decreased eGFR levels in patients with T2DM, which should be applied for control DKD. HDL and fasting CP have important effects on maintaining eGFR, and blood pressure and fasting CP can be used as new targets for subsequent diabetic kidney disease treatment. [ABSTRACT FROM AUTHOR]

Background: Compared with open radical prostatectomy (RP), laparoscopic or robot-assisted RP have shown a notable decrease in the incidence of organ dysfunction or potentially life-threating complications after surgery. However, despite advances, the postoperative length of hospital stay (LOS) remains longer than desired in many cases. The Postoperative Morbidity Survey (POMS) is a simple approach to detect complications capable of prolonging LOS. The primary objective of this study was to outline the incidence and type of early morbidity following laparoscopic or robot-assisted RP using modified POMS(m-POMS). The secondary objective was to investigate the correlation between m-POMS and postoperative LOS. Methods: A retrospective study of the electronic health records was performed for all eligible patients undergoing laparoscopic or robot-assisted RP over a one-year period (August 1, 2022 to July 31, 2023). Morbidity as defined by m-POMS was collected on postoperative day 1 (POD1), POD3, POD5 and POD8. Poisson regression models were employed to assess the correlation between positive m-POMS and postoperative LOS. Results: A total of 121 patients were included. Morbidity, as measured by m-POMS, occurred on POD1 (19.01%, 95% CI [13.01%, 26.91%]), POD3 (18.81%, 95% CI [12.39%, 27.52%]), POD5 (30.23%, 95% CI [18.60%, 45.10%]) and POD8 (35.29%, 95% CI [17.31%, 58.70%]). Two prevalent domains with positive m-POMS scores were infectious and pulmonary. The occurrence of morbidity as indicated by m-POMS was correlated with longer median (IQR) postoperative LOS on POD1 7 (5, 9) versus 4 (4, 6), POD3 7 (6, 11) versus 5(4, 6), and POD5 11 (6.5, 11) versus 7(6, 9) (p < 0.05) compared with patients who did not encounter m-POMS-assessed morbidity. Regression analysis showed that m-POMS-defined morbidity was correlated with longer postoperative LOS on POD1 and POD3. Conclusions: The incidence of early morbidity, as defined by m-POMS following radical prostatectomy, was approximately 20%, with infectious and pulmonary complications being the most prevalent. Short-term morbidity assessed by m-POMS was significantly associated with prolonged LOS. [ABSTRACT FROM AUTHOR]

Adolescents who have experienced harsh parenting face an increased risk of developing Internet addiction (IA) later in life. Few studies have examined the underlying mechanisms between harsh parenting and IA. This study explores the relationship between harsh parenting and IA, focusing on associations with emotional regulation difficulties and maladaptive cognitions. The study group consisted of 925 adolescents (Mage = 16.16, SDage = 0.72; 48.54% girls) who were recruited to complete a survey measuring the variables of harsh parenting, difficulties in emotional regulation, maladaptive cognitions, and IA. After accounting for age and gender, it was found that harsh parenting is directly associated with adolescents' IA (β = 0.07, p < 0.01). The chain mediating effect of emotional regulation difficulties and maladaptive cognitions was 0.08 (95% CI [0.06, 0.10]), which implies that a chain mediation was identified between harsh parenting and IA through the intermediary factors of emotional regulation difficulties and maladaptive cognitions. The findings suggest that addressing the emotional regulation difficulties and maladaptive cognitions could be important aspects to consider in interventions and prevention efforts aimed at reducing adolescent IA. [ABSTRACT FROM AUTHOR]

Background: The current outbreak of war in Palestine on the 7th of October 2023, heightened concerns about mental health and well-being of individuals, particularly undergraduate students in Palestine. Such traumatic experiences and political conflict did affect the social, economic, psychological, and academic status of university students in Palestine, in particular, nursing students. However, resilience is one of the moderators which may positively decrease the severity of those negative war-related symptoms. Aim: The study aimed to examine the moderation effect of resilience on the relationship between sociodemographic and personal characteristics and depression, anxiety, and stress among undergraduate nursing students in Palestine. Design and methods: A quantitative, descriptive-correlational design utilized to investigate anxiety, depression, stress, and resilience among nursing students. A convenience sample of 325 nursing students recruited from Al-Quds University were asked to respond to a self-administered questionnaire. Results: A total of 325 nursing students participated in this study. The analysis showed that the majority of the participants were experiencing extremely severe anxiety levels (43.7%, n = 142), while 25.5% (n = 83) were experiencing extremely severe depression and 14.5% (n = 47) were experiencing high-stress levels compared to 60% (n = 195) of the students were at their normal resilience level. There were statistically significant differences in the resilience based on sex (t323 = 2.994, p =.003). Knowing that males have higher resilience mean scores (M = 3.06, SD = 0.35) than females (M = 2.93, SD = 0.41) indicates higher resilience in males than females. After performing two steps of hierarchical regression, the results revealed that resilience negatively moderated the relationship between sociodemographics and depression, and anxiety. Conclusion: This study offers valuable insights into the mental health status of undergraduate nursing students in Palestine during the war. The results indicated that resilience is one of the pivotal moderators that may buffer anxiety and depression. The findings underscore the need for targeted interventions to address the diverse mental health needs of this population, considering the complex interplay of individual, demographic, and contextual factors. Future research should continue to explore these dynamics and evaluate the effectiveness of interventions promoting mental well-being during conflict. [ABSTRACT FROM AUTHOR]

Background: To explore the association of long non-coding RNA (lncRNA) SNHG1/ miR-195 axis with type 2 diabetes mellitus (T2DM) and islet function. Methods: The expression of SNHG1 and miR-195 was measured in T2DM patients and in healthy subjects. Correlation between indciators was evaluated using Pearson correlation analysis. INS-1 cells were used to perform the cell function assays. Insulin secretion by INS-1 was detected using ELISA. Cell counting kit-8 (CCK-8) and flow cytometry was used to detect cell proliferation and apoptosis. Luciferase report assay was to used to verify the target of SNHG1. Results: The expression of SNHG1 was increased and miR-195 level was decreased in the serum of T2DM patients. Both SNHG1 and miR-195 could be biomarkers for T2DM diagnosis. The fasting plasma glucose (FPG) and HbA1c were positively related to SNHG1 and negatively related to miR-195. SNHG1 inhibited insulin secretion, and cell proliferation and promoted apoptosis of INS-1 cells via binding to miR-195. Conclusions: Detection of SNHG1 and miR-195 might predict T2DM. SNHG1 could suppress proliferation and insulin secretion, but promote apoptosis of INS-1 cells via sponging miR-195. [ABSTRACT FROM AUTHOR]