1. Life course history of physical and sexual abuse is associated with cardiovascular disease risk among women living with and without HIV
- Author
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Appleton, Allison A, Kuniholm, Mark H, Vásquez, Elizabeth, Cohen, Mardge H, Donohue, Jessica, Floris-Moore, Michelle, Friedman, M Reuel, Hanna, David B, Mimiaga, Matthew J, Moran, Caitlin A, Plankey, Michael W, Teplin, Linda A, Shitole, Sanyog G, Ware, Deanna, Jones, Deborah L, and Wise, Jenni
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Cardiovascular ,Pediatric ,Infectious Diseases ,Drug Abuse (NIDA only) ,Heart Disease ,Prevention ,Substance Misuse ,Behavioral and Social Science ,HIV/AIDS ,Clinical Research ,2.3 Psychological ,social and economic factors ,Aetiology ,Good Health and Well Being ,Humans ,Female ,Child ,Adult ,HIV Infections ,Cardiovascular Diseases ,Life Change Events ,Sex Offenses ,Sexual Behavior ,Risk Factors ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveSexual and physical abuse predict cardiovascular disease (CVD) among women in the general population. Women living with HIV (WLWH) report more abuse and have higher CVD risk compared with other women, yet associations between abuse history and CVD have not been considered among WLWH. This study fills this gap, and describes possible pathways linking abuse to CVD risk among WLWH and women living without HIV (WLWOH).MethodsUsing 25 years of data from the Women's Interagency HIV Study (WIHS; n = 2734; WLWH n = 1963; WLWOH n = 771), we used longitudinal generalized estimating equations (GEE) to test associations between sexual and physical abuse with CVD risk. Framingham (FRS-H) and the American College of Cardiology/American Heart Association-Pooled Cohort Equation (ACC/AHA-PCE) scores were examined. Analyses were stratified by HIV-serostatus.ResultsAmong WLWH, childhood sexual abuse was associated with higher CVD risk ( βFRS-H = 1.25, SE = 1.08, P = 0.005; βACC/AHA-PCE = 1.14, SE = 1.07, P = 0.04) compared with no abuse. Adulthood sexual abuse was associated with higher CVD risk for WLWH ( βFRS-H = 1.39, SE = 1.08, P
- Published
- 2024