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2 results on '"Chvilicek M"'

1. A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

Author

Jessett E, David Feng, Thuyanh V. Nguyen, Yazan N. Billeh, Sophie Lambert, Lindsay Ng, Michael A. Buice, Ramakrishnan Iyer, Chelsea Nayan, Brown D, Sutton B, R.D. Young, Stefan Mihalas, Ali Williford, Brian Hu, Kat North, Julie A. Harris, Greggory Heller, Nicole Hancock, Yang Li, Jérôme Lecoq, John W. Phillips, Emily Gelfand, Séverine Durand, Fuhui Long, Melchior J, Justin T. Kiggins, Kiet Ngo, Nicholas Cain, Sarah A. Naylor, Sam Seid, Karly M. Turner, Hannah Choi, Melissa Reding, John Galbraith, Jackie Swapp, India Kato, Colin Farrell, Johnson K, Joshua H. Siegle, Kara Ronellenfitch, Corbett Bennett, Mollenkopf Ts, Douglas R. Ollerenshaw, Marius Pachitariu, Chvilicek M, David Reid, Kael Dai, Timothy C. Cox, Peter A. Groblewski, Robert Reid, Philip R. Nicovich, Anton Arkhipov, Olsen, Samuel D. Gale, Hytnen R, Luke Esposito, Robert Howard, Jennifer D. Whitesell, Daniel J. Denman, Linzy Casal, Clifford R. Slaughterbeck, Cho A, Shiella Caldejon, Liang E, Xiaoxuan Jia, Tamina K. Ramirez, Wayne Wakeman, Jennifer Luviano, Derric Williams, Daniel Millman, Jung Hoon Lee, Hongkui Zeng, de Vries Sej, Christof Koch, Arielle Leon, Dietzman R, Amy Bernard, Marina Garrett, Carol L. Thompson, Gabriel Koch Ocker, Nile Graddis, Peter Ledochowitsch, Miranda Robertson, Michelle Stoecklin, Jed Perkins, Kyla Mace, Michael Oliver, David Sullivan, and Ruweida Ahmed

Subjects
Retina, Visual perception, medicine.anatomical_structure, Neocortex, genetic structures, Computer science, Receptive field, Functional connectivity, medicine, Stimulus (physiology), Neuroscience
Abstract

The mammalian visual system, from retina to neocortex, has been extensively studied at both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is hierarchical, but characterization of cellular-level functional interactions across multiple levels of this hierarchy is lacking, partially due to the challenge of simultaneously recording activity across numerous regions. Here, we describe a large, open dataset (part of theAllen Brain Observatory) that surveys spiking from units in six cortical and two thalamic regions responding to a battery of visual stimuli. Using spike cross-correlation analysis, we find that inter-area functional connectivity mirrors the anatomical hierarchy from theAllen Mouse Brain Connectivity Atlas. Classical functional measures of hierarchy, including visual response latency, receptive field size, phase-locking to a drifting grating stimulus, and autocorrelation timescale are all correlated with the anatomical hierarchy. Moreover, recordings during a visual task support the behavioral relevance of hierarchical processing. Overall, this dataset and the hierarchy we describe provide a foundation for understanding coding and dynamics in the mouse cortico-thalamic visual system.

Published
2019
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2. Survey of spiking in the mouse visual system reveals functional hierarchy.

Author

Siegle JH, Jia X, Durand S, Gale S, Bennett C, Graddis N, Heller G, Ramirez TK, Choi H, Luviano JA, Groblewski PA, Ahmed R, Arkhipov A, Bernard A, Billeh YN, Brown D, Buice MA, Cain N, Caldejon S, Casal L, Cho A, Chvilicek M, Cox TC, Dai K, Denman DJ, de Vries SEJ, Dietzman R, Esposito L, Farrell C, Feng D, Galbraith J, Garrett M, Gelfand EC, Hancock N, Harris JA, Howard R, Hu B, Hytnen R, Iyer R, Jessett E, Johnson K, Kato I, Kiggins J, Lambert S, Lecoq J, Ledochowitsch P, Lee JH, Leon A, Li Y, Liang E, Long F, Mace K, Melchior J, Millman D, Mollenkopf T, Nayan C, Ng L, Ngo K, Nguyen T, Nicovich PR, North K, Ocker GK, Ollerenshaw D, Oliver M, Pachitariu M, Perkins J, Reding M, Reid D, Robertson M, Ronellenfitch K, Seid S, Slaughterbeck C, Stoecklin M, Sullivan D, Sutton B, Swapp J, Thompson C, Turner K, Wakeman W, Whitesell JD, Williams D, Williford A, Young R, Zeng H, Naylor S, Phillips JW, Reid RC, Mihalas S, Olsen SR, and Koch C

Subjects
Animals, Datasets as Topic, Electrophysiology, Male, Mice, Mice, Inbred C57BL, Photic Stimulation, Thalamus anatomy & histology, Thalamus cytology, Thalamus physiology, Visual Cortex cytology, Action Potentials physiology, Visual Cortex anatomy & histology, Visual Cortex physiology
Abstract

The anatomy of the mammalian visual system, from the retina to the neocortex, is organized hierarchically 1 . However, direct observation of cellular-level functional interactions across this hierarchy is lacking due to the challenge of simultaneously recording activity across numerous regions. Here we describe a large, open dataset-part of the Allen Brain Observatory 2 -that surveys spiking from tens of thousands of units in six cortical and two thalamic regions in the brains of mice responding to a battery of visual stimuli. Using cross-correlation analysis, we reveal that the organization of inter-area functional connectivity during visual stimulation mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas 3 . We find that four classical hierarchical measures-response latency, receptive-field size, phase-locking to drifting gratings and response decay timescale-are all correlated with the hierarchy. Moreover, recordings obtained during a visual task reveal that the correlation between neural activity and behavioural choice also increases along the hierarchy. Our study provides a foundation for understanding coding and signal propagation across hierarchically organized cortical and thalamic visual areas.

Published
2021
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