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6. Identification of genetic determinants of bedaquiline resistance in Mycobacterium tuberculosis in Ural region, Russia.

Author

Umpeleva T, Chetverikova E, Belyaev D, Eremeeva N, Boteva T, Golubeva L, Vakhrusheva D, and Vasilieva I

Subjects
Humans, Microbial Sensitivity Tests, Antitubercular Agents pharmacology, Antitubercular Agents therapeutic use, Russia, Mycobacterium tuberculosis genetics, Tuberculosis, Multidrug-Resistant microbiology, Diarylquinolines
Abstract

Collecting data on rare Mycobacterium tuberculosis ( Mtb ) clinical isolates with resistance to the new anti-tuberculosis drug bedaquiline is an important task for improving antimicrobial susceptibility testing methods. Nanopore whole genome sequencing, the proportion method on Middlebrook 7H11 medium, and BACTEC MGIT 960 assays were used to analyze genotypic and phenotypic resistance to bedaquiline. We found four mutations: atpE I66M, atpE А63Р, Rv0678 А36Т, and Rv0678 S53P in five isolates with different levels of phenotypic bedaquiline resistance., Importance: Bedaquiline (BDQ) is a new anti-tuberculosis drug. The phenotypic and genotypic data describing the mechanism of drug resistance are critical for the design of rapid and accurate diagnostic tests. We consider that our work, which describes genotypic and phenotypic resistance to BDQ, can contribute to the standardization of drug susceptibility testing., Competing Interests: The authors declare no conflict of interest.

Published
2024
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7. Low-Grade Fibromyxoid Sarcoma of the Lateral Skull Base: Presentation of Two Cases.

Author

Chetverikova E and Kasenõmm P

Abstract

Low-grade fibromyxoid sarcoma (LGFMS) is a rare slow-growing malignant tumour with a deceptively benign histologic appearance. Herein, we report two cases of LGFMS with variable clinical presentations. The first case was a 17-year-old female who referred to our department due to deaf ear on the right together with ipsilateral gag reflex impairment and globus sensation in the pharynx. The second case was a 35-year-old female with recurrent LGFMS, suffering from headaches, vertigo, and episodes of loss of consciousness. LGFMS of the temporal bone is a rare pathology, and to the best of our knowledge, no such cases have been reported before.

Published
2019
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