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3. Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release

Author

Shiota, Tomoyuki, primary, Li, Zhucui, additional, Chen, Guan-Yuan, additional, McKnight, Kevin L., additional, Shirasaki, Takayoshi, additional, Yonish, Bryan, additional, Kim, Heyjeong, additional, Fritch, Ethan J., additional, Sheahan, Timothy P., additional, Muramatsu, Masamichi, additional, Kapustina, Maryna, additional, Cameron, Craig E., additional, Li, You, additional, Zhang, Qibin, additional, and Lemon, Stanley M., additional

Published
2023
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20. [Latest Findings on the Interaction Mechanism Between Depressive Disorder and Intestinal Permeability].

Author

Zhang ZH, Xu DY, Chen GY, Teng T, Wu HY, and Zhou XY

Subjects
Humans, Pituitary-Adrenal System, Intestines microbiology, Permeability, Intestinal Mucosa metabolism, Intestinal Mucosa microbiology, Intestinal Mucosa pathology, Hypothalamo-Hypophyseal System, Depressive Disorder metabolism, Depressive Disorder pathology
Abstract

The intestinal barrier, a complex structure consisting of multiple layers of defense barriers, blocks the transfer of intestinal and foreign bacteria and their metabolites into the internal environment of the human body. Intestinal permeability can be used to evaluate the integrity of the intestinal barrier. Increased intestinal permeability has been observed in patients with depressive disorder. Some studies have reported an interaction between depressive disorder and intestinal barrier. Herein, we reviewed reported findings on the mechanisms of how systematic low-grade inflammation, vagal nerve dysfunction, and hypothalamic-pituitary-adrenal axis dysfunction cause changes in intestinal permeability in patients with depressive disorder and the pathogenic mechanism of how bacterial translocation caused by damaged intestinal barrier leads to depressive disorder. In addition, the potential mechanisms of how antidepressants improve intestinal permeability and how probiotics improve depressive disorder have been discussed., (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).)

Published
2023
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